Unicorn Papers
Top ‱ cited papers from PUBMED
Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authorsCurrently, the list contains 4222 papers with ECcit ≥ 1108.0
‱ - permyriad,
, literally meaning "for (every) myriad (ten thousand)"
Volume 70, June 2026
| No. | Citations | ECcit | RCR | ECRCR | Title | Authors | Journal | Year | PMID | Article(?) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 226517 | 226517.0 | 6234.8 | 6234.8 | Cleavage of structural proteins during the assembly of the head of bacteriophage T4. | U K Laemmli | Nature | 1970 | 5432063 | Yes |
| 2 | 183839 | 183839.0 | 6030.7 | 6030.7 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. | M M Bradford | Anal Biochem | 1976 | 942051 | Yes |
| 3 | 288675 | 72168.8 | 0.0 | 0.0 | Protein measurement with the Folin phenol reagent. | O H Lowry, N J Rosebrough, A L Farr, R J Randall | J Biol Chem | 1951 | 14907713 | Yes |
| 4 | 142456 | 71228.0 | 3934.6 | 1967.3 | Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. | K J Livak, T D Schmittgen | Methods | 2001 | 11846609 | Yes |
| 5 | 47053 | 47053.0 | 1515.4 | 1515.4 | A short history of SHELX. | George M Sheldrick | Acta Crystallogr A | 2008 | 18156677 | Yes |
| 6 | 39273 | 39273.0 | 1308.8 | 1308.8 | Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. | T Mosmann | J Immunol Methods | 1983 | 6606682 | Yes |
| 7 | 64832 | 32416.0 | 2017.5 | 1008.8 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. | P Chomczynski, N Sacchi | Anal Biochem | 1987 | 2440339 | Yes |
| 8 | 30629 | 30629.0 | 781.0 | 781.0 | MUSCLE: multiple sequence alignment with high accuracy and high throughput. | Robert C Edgar | Nucleic Acids Res | 2004 | 15034147 | Yes |
| 9 | 30280 | 30280.0 | 791.3 | 791.3 | Detection of specific sequences among DNA fragments separated by gel electrophoresis. | E M Southern | J Mol Biol | 1975 | 1195397 | Yes |
| 10 | 29937 | 29937.0 | 914.4 | 914.4 | The assessment and analysis of handedness: the Edinburgh inventory. | R C Oldfield | Neuropsychologia | 1971 | 5146491 | Yes |
| 11 | 29397 | 29397.0 | 685.5 | 685.5 | MicroRNAs: genomics, biogenesis, mechanism, and function. | David P Bartel | Cell | 2004 | 14744438 | No |
| 12 | 28194 | 28194.0 | 0.0 | 0.0 | A rating scale for depression. | M Hamilton | J Neurol Neurosurg Psychiatry | 1960 | 14399272 | Yes |
| 13 | 26974 | 26974.0 | 677.6 | 677.6 | A new mathematical model for relative quantification in real-time RT-PCR. | M W Pfaffl | Nucleic Acids Res | 2001 | 11328886 | Yes |
| 14 | 26099 | 26099.0 | 843.8 | 843.8 | Confidence Limits On Phylogenies: An Approach Using The Bootstrap. | Joseph Felsenstein | Evolution | 1985 | 28561359 | Yes |
| 15 | 24889 | 24889.0 | 702.6 | 702.6 | Projector augmented-wave method. | P E Blochl | Phys Rev B Condens Matter | 1994 | 9976227 | Yes |
| 16 | 49366 | 24683.0 | 1530.3 | 765.1 | Hallmarks of cancer: the next generation. | Douglas Hanahan, Robert A Weinberg | Cell | 2011 | 21376230 | No |
| 17 | 71312 | 23770.7 | 2554.9 | 851.6 | "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. | M F Folstein, S E Folstein, P R McHugh | J Psychiatr Res | 1975 | 1202204 | Yes |
| 18 | 69100 | 23033.3 | 2494.4 | 831.5 | Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. | Michael I Love, Wolfgang Huber, Simon Anders | Genome Biol | 2014 | 25516281 | Yes |
| 19 | 22411 | 22411.0 | 779.7 | 779.7 | Density-functional exchange-energy approximation with correct asymptotic behavior. | A D Becke | Phys Rev A Gen Phys | 1988 | 9900728 | Yes |
| 20 | 66520 | 22173.3 | 1626.0 | 542.0 | DNA sequencing with chain-terminating inhibitors. | F Sanger, S Nicklen, A R Coulson | Proc Natl Acad Sci U S A | 1977 | 271968 | Yes |
| 21 | 42481 | 21240.5 | 1367.1 | 683.5 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | N Saitou, M Nei | Mol Biol Evol | 1987 | 3447015 | Yes |
| 22 | 20750 | 20750.0 | 0.0 | 0.0 | Tissue sulfhydryl groups. | G L Ellman | Arch Biochem Biophys | 1959 | 13650640 | Yes |
| 23 | 20686 | 20686.0 | 839.0 | 839.0 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. | Alexandros Stamatakis | Bioinformatics | 2014 | 24451623 | Yes |
| 24 | 20529 | 20529.0 | 0.0 | 0.0 | The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. | E S Reynolds | J Cell Biol | 1963 | 13986422 | Yes |
| 25 | 40892 | 20446.0 | 1280.4 | 640.2 | Fast gapped-read alignment with Bowtie 2. | Ben Langmead, Steven L Salzberg | Nat Methods | 2012 | 22388286 | Yes |
| 26 | 40671 | 20335.5 | 1625.4 | 812.7 | The measurement of observer agreement for categorical data. | J R Landis, G G Koch | Biometrics | 1977 | 843571 | Yes |
| 27 | 60143 | 20047.7 | 1854.1 | 618.0 | Generalized Gradient Approximation Made Simple. | J P Perdew, K Burke, M Ernzerhof | Phys Rev Lett | 1996 | 10062328 | Yes |
| 28 | 38281 | 19140.5 | 1851.5 | 925.8 | Statistical methods for assessing agreement between two methods of clinical measurement. | J M Bland, D G Altman | Lancet | 1986 | 2868172 | Yes |
| 29 | 37649 | 18824.5 | 980.4 | 490.2 | Fast and accurate short read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2009 | 19451168 | Yes |
| 30 | 18800 | 18800.0 | 641.9 | 641.9 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. | M Kimura | J Mol Evol | 1980 | 7463489 | Yes |
| 31 | 18714 | 18714.0 | 848.4 | 848.4 | A power primer. | J Cohen | Psychol Bull | 1992 | 19565683 | Yes |
| 32 | 18062 | 18062.0 | 857.2 | 857.2 | Crystal structure refinement with SHELXL. | George M Sheldrick | Acta Crystallogr C Struct Chem | 2015 | 25567568 | Yes |
| 33 | 53707 | 17902.3 | 1604.3 | 534.8 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. | H Towbin, T Staehelin, J Gordon | Proc Natl Acad Sci U S A | 1979 | 388439 | Yes |
| 34 | 17459 | 17459.0 | 477.8 | 477.8 | Atherosclerosis--an inflammatory disease. | R Ross | N Engl J Med | 1999 | 9887164 | No |
| 35 | 34367 | 17183.5 | 1404.9 | 702.5 | The hospital anxiety and depression scale. | A S Zigmond, R P Snaith | Acta Psychiatr Scand | 1983 | 6880820 | Yes |
| 36 | 33829 | 16914.5 | 954.1 | 477.1 | Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. | G Kresse, J Furthmuller | Phys Rev B Condens Matter | 1996 | 9984901 | Yes |
| 37 | 33689 | 16844.5 | 0.0 | 0.0 | A rapid method of total lipid extraction and purification. | E G Bligh, W J Dyer | Can J Biochem Physiol | 1959 | 13671378 | Yes |
| 38 | 16783 | 16783.0 | 0.0 | 0.0 | Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. | B J Davis | Ann N Y Acad Sci | 1964 | 14240539 | Yes |
| 39 | 16635 | 16635.0 | 661.7 | 661.7 | Catalase in vitro. | H Aebi | Methods Enzymol | 1984 | 6727660 | Yes |
| 40 | 32946 | 16473.0 | 1271.4 | 635.7 | Meta-analysis in clinical trials. | R DerSimonian, N Laird | Control Clin Trials | 1986 | 3802833 | Yes |
| 41 | 16429 | 16429.0 | 422.7 | 422.7 | MicroRNAs: target recognition and regulatory functions. | David P Bartel | Cell | 2009 | 19167326 | No |
| 42 | 16238 | 16238.0 | 433.6 | 433.6 | High resolution two-dimensional electrophoresis of proteins. | P H O'Farrell | J Biol Chem | 1975 | 236308 | Yes |
| 43 | 15942 | 15942.0 | 0.0 | 0.0 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. | K Burton | Biochem J | 1956 | 13293190 | Yes |
| 44 | 46814 | 15604.7 | 1411.1 | 470.4 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. | J D Thompson, D G Higgins, T J Gibson | Nucleic Acids Res | 1994 | 7984417 | Yes |
| 45 | 15515 | 15515.0 | 608.3 | 608.3 | Investigation of the freely available easy-to-use software 'EZR' for medical statistics. | Y Kanda | Bone Marrow Transplant | 2013 | 23208313 | Yes |
| 46 | 46302 | 15434.0 | 1732.8 | 577.6 | Trimmomatic: a flexible trimmer for Illumina sequence data. | Anthony M Bolger, Marc Lohse, Bjoern Usadel | Bioinformatics | 2014 | 24695404 | Yes |
| 47 | 29372 | 14686.0 | 1101.8 | 550.9 | MAFFT multiple sequence alignment software version 7: improvements in performance and usability. | Kazutaka Katoh, Daron M Standley | Mol Biol Evol | 2013 | 23329690 | Yes |
| 48 | 43486 | 14495.3 | 0.0 | 0.0 | A simple method for the isolation and purification of total lipides from animal tissues. | J Folch, M Lees, G H Sloane Stanley | J Biol Chem | 1957 | 13428781 | Yes |
| 49 | 14468 | 14468.0 | 521.7 | 521.7 | Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. | Andreas Stang | Eur J Epidemiol | 2010 | 20652370 | Yes |
| 50 | 14459 | 14459.0 | 371.8 | 371.8 | Xds. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124692 | Yes |
| 51 | 28545 | 14272.5 | 891.3 | 445.6 | Quantifying heterogeneity in a meta-analysis. | Julian P T Higgins, Simon G Thompson | Stat Med | 2002 | 12111919 | Yes |
| 52 | 28077 | 14038.5 | 598.8 | 299.4 | Coot: model-building tools for molecular graphics. | Paul Emsley, Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2004 | 15572765 | Yes |
| 53 | 14003 | 14003.0 | 603.3 | 603.3 | Prokka: rapid prokaryotic genome annotation. | Torsten Seemann | Bioinformatics | 2014 | 24642063 | Yes |
| 54 | 69751 | 13950.2 | 2074.9 | 415.0 | Basic local alignment search tool. | S F Altschul, W Gish, W Miller, E W Myers, D J Lipman | J Mol Biol | 1990 | 2231712 | Yes |
| 55 | 27759 | 13879.5 | 648.7 | 324.4 | KEGG: kyoto encyclopedia of genes and genomes. | M Kanehisa, S Goto | Nucleic Acids Res | 2000 | 10592173 | Yes |
| 56 | 13872 | 13872.0 | 615.8 | 615.8 | Self-efficacy: toward a unifying theory of behavioral change. | A Bandura | Psychol Rev | 1977 | 847061 | Yes |
| 57 | 13704 | 13704.0 | 447.5 | 447.5 | Search and clustering orders of magnitude faster than BLAST. | Robert C Edgar | Bioinformatics | 2010 | 20709691 | Yes |
| 58 | 13510 | 13510.0 | 448.9 | 448.9 | The Psychophysics Toolbox. | D H Brainard | Spat Vis | 1997 | 9176952 | Yes |
| 59 | 40508 | 13502.7 | 1443.0 | 481.0 | Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. | C Lee, W Yang, R G Parr | Phys Rev B Condens Matter | 1988 | 9944570 | Yes |
| 60 | 40241 | 13413.7 | 1097.0 | 365.7 | VMD: visual molecular dynamics. | W Humphrey, A Dalke, K Schulten | J Mol Graph | 1996 | 8744570 | Yes |
| 61 | 26775 | 13387.5 | 1192.1 | 596.0 | The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. | J E Ware, C D Sherbourne | Med Care | 1992 | 1593914 | Yes |
| 62 | 13191 | 13191.0 | 223.2 | 223.2 | The genetics of Caenorhabditis elegans. | S Brenner | Genetics | 1974 | 4366476 | Yes |
| 63 | 39535 | 13178.3 | 1321.2 | 440.4 | NIH Image to ImageJ: 25 years of image analysis. | Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri | Nat Methods | 2012 | 22930834 | No |
| 64 | 12796 | 12796.0 | 432.9 | 432.9 | Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). | J F Kurtzke | Neurology | 1983 | 6685237 | Yes |
| 65 | 12665 | 12665.0 | 0.0 | 0.0 | Phosphorus assay in column chromatography. | G R Bartlett | J Biol Chem | 1959 | 13641241 | Yes |
| 66 | 12565 | 12565.0 | 504.0 | 504.0 | A new method for measuring daytime sleepiness: the Epworth sleepiness scale. | M W Johns | Sleep | 1991 | 1798888 | Yes |
| 67 | 12386 | 12386.0 | 576.4 | 576.4 | SHELXT - integrated space-group and crystal-structure determination. | George M Sheldrick | Acta Crystallogr A Found Adv | 2015 | 25537383 | Yes |
| 68 | 24523 | 12261.5 | 557.8 | 278.9 | Processing of X-ray diffraction data collected in oscillation mode. | Z Otwinowski, W Minor | Methods Enzymol | 1997 | 27754618 | Yes |
| 69 | 48656 | 12164.0 | 1581.9 | 395.5 | Measuring inconsistency in meta-analyses. | Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman | BMJ | 2003 | 12958120 | No |
| 70 | 11483 | 11483.0 | 317.8 | 317.8 | Semiempirical GGA-type density functional constructed with a long-range dispersion correction. | Stefan Grimme | J Comput Chem | 2006 | 16955487 | Yes |
| 71 | 22591 | 11295.5 | 975.3 | 487.6 | The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. | R M Baron, D A Kenny | J Pers Soc Psychol | 1986 | 3806354 | Yes |
| 72 | 21988 | 10994.0 | 693.6 | 346.8 | AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. | Oleg Trott, Arthur J Olson | J Comput Chem | 2010 | 19499576 | Yes |
| 73 | 32966 | 10988.7 | 1108.3 | 369.4 | The PHQ-9: validity of a brief depression severity measure. | K Kroenke, R L Spitzer, J B Williams | J Gen Intern Med | 2001 | 11556941 | Yes |
| 74 | 10984 | 10984.0 | 0.0 | 0.0 | On the origin of cancer cells. | O Warburg | Science | 1956 | 13298683 | Yes |
| 75 | 10943 | 10943.0 | 386.1 | 386.1 | Structure validation in chemical crystallography. | Anthony L Spek | Acta Crystallogr D Biol Crystallogr | 2009 | 19171970 | Yes |
| 76 | 10814 | 10814.0 | 306.6 | 306.6 | The blockade of immune checkpoints in cancer immunotherapy. | Drew M Pardoll | Nat Rev Cancer | 2012 | 22437870 | No |
| 77 | 21556 | 10778.0 | 570.8 | 285.4 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. | A P Feinberg, B Vogelstein | Anal Biochem | 1983 | 6312838 | Yes |
| 78 | 10673 | 10673.0 | 460.6 | 460.6 | Psychophysical bases of perceived exertion. | G A Borg | Med Sci Sports Exerc | 1982 | 7154893 | Yes |
| 79 | 42652 | 10663.0 | 1534.2 | 383.6 | Bias in meta-analysis detected by a simple, graphical test. | M Egger, G Davey Smith, M Schneider, C Minder | BMJ | 1997 | 9310563 | Yes |
| 80 | 42537 | 10634.2 | 1591.4 | 397.9 | A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. | M E Charlson, P Pompei, K L Ales, C R MacKenzie | J Chronic Dis | 1987 | 3558716 | Yes |
| 81 | 31706 | 10568.7 | 856.2 | 285.4 | edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. | Mark D Robinson, Davis J McCarthy, Gordon K Smyth | Bioinformatics | 2010 | 19910308 | Yes |
| 82 | 10475 | 10475.0 | 299.5 | 299.5 | Evolutionary trees from DNA sequences: a maximum likelihood approach. | J Felsenstein | J Mol Evol | 1981 | 7288891 | Yes |
| 83 | 10353 | 10353.0 | 260.2 | 260.2 | PAML 4: phylogenetic analysis by maximum likelihood. | Ziheng Yang | Mol Biol Evol | 2007 | 17483113 | Yes |
| 84 | 10316 | 10316.0 | 0.0 | 0.0 | Improvements in epoxy resin embedding methods. | J H Luft | J Biophys Biochem Cytol | 1961 | 13764136 | Yes |
| 85 | 20491 | 10245.5 | 564.6 | 282.3 | Analyzing real-time PCR data by the comparative C(T) method. | Thomas D Schmittgen, Kenneth J Livak | Nat Protoc | 2008 | 18546601 | Yes |
| 86 | 10230 | 10230.0 | 221.4 | 221.4 | Mfold web server for nucleic acid folding and hybridization prediction. | Michael Zuker | Nucleic Acids Res | 2003 | 12824337 | Yes |
| 87 | 10206 | 10206.0 | 269.6 | 269.6 | Canonical dynamics: Equilibrium phase-space distributions. | W G Hoover | Phys Rev A Gen Phys | 1985 | 9895674 | Yes |
| 88 | 10173 | 10173.0 | 415.7 | 415.7 | UPARSE: highly accurate OTU sequences from microbial amplicon reads. | Robert C Edgar | Nat Methods | 2013 | 23955772 | Yes |
| 89 | 20344 | 10172.0 | 492.4 | 246.2 | BEDTools: a flexible suite of utilities for comparing genomic features. | Aaron R Quinlan, Ira M Hall | Bioinformatics | 2010 | 20110278 | Yes |
| 90 | 10144 | 10144.0 | 432.8 | 432.8 | Minimap2: pairwise alignment for nucleotide sequences. | Heng Li | Bioinformatics | 2018 | 29750242 | Yes |
| 91 | 10023 | 10023.0 | 304.8 | 304.8 | Vitamin D deficiency. | Michael F Holick | N Engl J Med | 2007 | 17634462 | No |
| 92 | 19824 | 9912.0 | 0.0 | 0.0 | The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. | K Weber, M Osborn | J Biol Chem | 1969 | 5806584 | Yes |
| 93 | 19668 | 9834.0 | 507.1 | 253.6 | A simple method for displaying the hydropathic character of a protein. | J Kyte, R F Doolittle | J Mol Biol | 1982 | 7108955 | Yes |
| 94 | 9781 | 9781.0 | 268.5 | 268.5 | Apoptosis: a review of programmed cell death. | Susan Elmore | Toxicol Pathol | 2007 | 17562483 | No |
| 95 | 19477 | 9738.5 | 435.2 | 217.6 | The hallmarks of cancer. | D Hanahan, R A Weinberg | Cell | 2000 | 10647931 | No |
| 96 | 9730 | 9730.0 | 270.8 | 270.8 | RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. | Alexandros Stamatakis | Bioinformatics | 2006 | 16928733 | Yes |
| 97 | 9727 | 9727.0 | 0.0 | 0.0 | Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. | D I Arnon | Plant Physiol | 1949 | 16654194 | Yes |
| 98 | 29159 | 9719.7 | 765.5 | 255.2 | Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nat Protoc | 2009 | 19131956 | Yes |
| 99 | 9701 | 9701.0 | 328.0 | 328.0 | Banting lecture 1988. Role of insulin resistance in human disease. | G M Reaven | Diabetes | 1988 | 3056758 | No |
| 100 | 38744 | 9686.0 | 1395.2 | 348.8 | G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. | Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner | Behav Res Methods | 2007 | 17695343 | Yes |
| 101 | 19349 | 9674.5 | 1213.0 | 606.5 | A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. | Terry K Koo, Mae Y Li | J Chiropr Med | 2016 | 27330520 | Yes |
| 102 | 19330 | 9665.0 | 477.8 | 238.9 | WGCNA: an R package for weighted correlation network analysis. | Peter Langfelder, Steve Horvath | BMC Bioinformatics | 2008 | 19114008 | Yes |
| 103 | 9557 | 9557.0 | 259.0 | 259.0 | Studies on transformation of Escherichia coli with plasmids. | D Hanahan | J Mol Biol | 1983 | 6345791 | Yes |
| 104 | 19096 | 9548.0 | 726.3 | 363.1 | Three approaches to qualitative content analysis. | Hsiu-Fang Hsieh, Sarah E Shannon | Qual Health Res | 2005 | 16204405 | Yes |
| 105 | 28419 | 9473.0 | 1096.4 | 365.5 | Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. | Allison Tong, Peter Sainsbury, Jonathan Craig | Int J Qual Health Care | 2007 | 17872937 | Yes |
| 106 | 18916 | 9458.0 | 433.9 | 216.9 | Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. | Kazutoshi Takahashi, Shinya Yamanaka | Cell | 2006 | 16904174 | Yes |
| 107 | 9454 | 9454.0 | 263.2 | 263.2 | Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. | M C Hochberg | Arthritis Rheum | 1997 | 9324032 | Yes |
| 108 | 47218 | 9443.6 | 1907.4 | 381.5 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | PLoS Med | 2009 | 19621072 | No |
| 109 | 28169 | 9389.7 | 1450.0 | 483.3 | MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. | Sudhir Kumar, Glen Stecher, Koichiro Tamura | Mol Biol Evol | 2016 | 27004904 | Yes |
| 110 | 9261 | 9261.0 | 289.9 | 289.9 | AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. | R W Cox | Comput Biomed Res | 1996 | 8812068 | Yes |
| 111 | 9252 | 9252.0 | 241.9 | 241.9 | Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. | P S Thomas | Proc Natl Acad Sci U S A | 1980 | 6159641 | Yes |
| 112 | 9224 | 9224.0 | 273.1 | 273.1 | The pathogenesis of atherosclerosis: a perspective for the 1990s. | R Ross | Nature | 1993 | 8479518 | No |
| 113 | 9180 | 9180.0 | 0.0 | 0.0 | The assessment of anxiety states by rating. | M Hamilton | Br J Med Psychol | 1959 | 13638508 | Yes |
| 114 | 9098 | 9098.0 | 189.9 | 189.9 | Linear models and empirical bayes methods for assessing differential expression in microarray experiments. | Gordon K Smyth | Stat Appl Genet Mol Biol | 2004 | 16646809 | Yes |
| 115 | 9071 | 9071.0 | 242.9 | 242.9 | Integrins: versatility, modulation, and signaling in cell adhesion. | R O Hynes | Cell | 1992 | 1555235 | No |
| 116 | 26939 | 8979.7 | 942.0 | 314.0 | Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. | Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien | Ann Surg | 2004 | 15273542 | Yes |
| 117 | 8945 | 8945.0 | 198.7 | 198.7 | The functions of animal microRNAs. | Victor Ambros | Nature | 2004 | 15372042 | No |
| 118 | 8891 | 8891.0 | 441.6 | 441.6 | Comparative fit indexes in structural models. | P M Bentler | Psychol Bull | 1990 | 2320703 | Yes |
| 119 | 8743 | 8743.0 | 389.6 | 389.6 | Interrater reliability: the kappa statistic. | Mary L McHugh | Biochem Med (Zagreb) | 2012 | 23092060 | Yes |
| 120 | 17346 | 8673.0 | 412.6 | 206.3 | Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. | S J Clough, A F Bent | Plant J | 1998 | 10069079 | Yes |
| 121 | 8471 | 8471.0 | 238.4 | 238.4 | Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. | F Tajima | Genetics | 1989 | 2513255 | Yes |
| 122 | 8346 | 8346.0 | 328.7 | 328.7 | The Strengths and Difficulties Questionnaire: a research note. | R Goodman | J Child Psychol Psychiatry | 1997 | 9255702 | Yes |
| 123 | 16641 | 8320.5 | 525.0 | 262.5 | EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. | Arnaud Delorme, Scott Makeig | J Neurosci Methods | 2004 | 15102499 | Yes |
| 124 | 8317 | 8317.0 | 228.8 | 228.8 | Fast robust automated brain extraction. | Stephen M Smith | Hum Brain Mapp | 2002 | 12391568 | No |
| 125 | 8294 | 8294.0 | 275.0 | 275.0 | The Clinical Dementia Rating (CDR): current version and scoring rules. | J C Morris | Neurology | 1993 | 8232972 | Yes |
| 126 | 8281 | 8281.0 | 282.4 | 282.4 | An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. | Peter C Austin | Multivariate Behav Res | 2011 | 21818162 | Yes |
| 127 | 16462 | 8231.0 | 441.6 | 220.8 | MrBayes 3: Bayesian phylogenetic inference under mixed models. | Fredrik Ronquist, John P Huelsenbeck | Bioinformatics | 2003 | 12912839 | Yes |
| 128 | 8158 | 8158.0 | 0.0 | 0.0 | Solvent content of protein crystals. | B W Matthews | J Mol Biol | 1968 | 5700707 | Yes |
| 129 | 16286 | 8143.0 | 452.1 | 226.1 | RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. | Bo Li, Colin N Dewey | BMC Bioinformatics | 2011 | 21816040 | Yes |
| 130 | 8132 | 8132.0 | 177.6 | 177.6 | Chromatin modifications and their function. | Tony Kouzarides | Cell | 2007 | 17320507 | No |
| 131 | 16148 | 8074.0 | 454.9 | 227.4 | Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. | Florian Weigend, Reinhart Ahlrichs | Phys Chem Chem Phys | 2005 | 16240044 | Yes |
| 132 | 8069 | 8069.0 | 151.8 | 151.8 | Tumor angiogenesis: therapeutic implications. | J Folkman | N Engl J Med | 1971 | 4938153 | No |
| 133 | 8037 | 8037.0 | 271.7 | 271.7 | Density-functional approximation for the correlation energy of the inhomogeneous electron gas. | J P Perdew | Phys Rev B Condens Matter | 1986 | 9938299 | Yes |
| 134 | 16070 | 8035.0 | 569.0 | 284.5 | Multiwfn: a multifunctional wavefunction analyzer. | Tian Lu, Feiwu Chen | J Comput Chem | 2012 | 22162017 | Yes |
| 135 | 8030 | 8030.0 | 231.4 | 231.4 | A modified poisson regression approach to prospective studies with binary data. | Guangyong Zou | Am J Epidemiol | 2004 | 15033648 | Yes |
| 136 | 7947 | 7947.0 | 220.8 | 220.8 | "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. | W N Burnette | Anal Biochem | 1981 | 6266278 | Yes |
| 137 | 7909 | 7909.0 | 226.0 | 226.0 | A simplification of the protein assay method of Lowry et al. which is more generally applicable. | G L Peterson | Anal Biochem | 1977 | 603028 | Yes |
| 138 | 7881 | 7881.0 | 261.3 | 261.3 | The VideoToolbox software for visual psychophysics: transforming numbers into movies. | D G Pelli | Spat Vis | 1997 | 9176953 | Yes |
| 139 | 23527 | 7842.3 | 690.0 | 230.0 | Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. | W T Friedewald, R I Levy, D S Fredrickson | Clin Chem | 1972 | 4337382 | Yes |
| 140 | 7799 | 7799.0 | 224.3 | 224.3 | The role of protein kinase C in cell surface signal transduction and tumour promotion. | Y Nishizuka | Nature | 1984 | 6232463 | No |
| 141 | 7738 | 7738.0 | 0.0 | 0.0 | Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. | A Boyum | Scand J Clin Lab Invest Suppl | 1968 | 4179068 | Yes |
| 142 | 7721 | 7721.0 | 212.1 | 212.1 | Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. | J R Vane | Nat New Biol | 1971 | 5284360 | Yes |
| 143 | 53770 | 7681.4 | 1482.9 | 211.8 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. | S F Altschul, T L Madden, A A Schaffer, J Zhang, Z Zhang, W Miller, D J Lipman | Nucleic Acids Res | 1997 | 9254694 | No |
| 144 | 7427 | 7427.0 | 0.0 | 0.0 | A low-viscosity epoxy resin embedding medium for electron microscopy. | A R Spurr | J Ultrastruct Res | 1969 | 4887011 | Yes |
| 145 | 7362 | 7362.0 | 0.0 | 0.0 | Index for rating diagnostic tests. | W J Youden | Cancer | 1950 | 15405679 | Yes |
| 146 | 14497 | 7248.5 | 619.4 | 309.7 | Intraclass correlations: uses in assessing rater reliability. | P E Shrout, J L Fleiss | Psychol Bull | 1979 | 18839484 | No |
| 147 | 7222 | 7222.0 | 254.6 | 254.6 | Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. | Ilan H Meyer | Psychol Bull | 2003 | 12956539 | No |
| 148 | 7138 | 7138.0 | 259.1 | 259.1 | FreeSurfer. | Bruce Fischl | Neuroimage | 2012 | 22248573 | No |
| 149 | 7128 | 7128.0 | 0.0 | 0.0 | A Self-Rating Depression Scale. | W W Zung | Arch Gen Psychiatry | 1965 | 14221692 | Yes |
| 150 | 7104 | 7104.0 | 204.9 | 204.9 | TreeView: an application to display phylogenetic trees on personal computers. | R D Page | Comput Appl Biosci | 1996 | 8902363 | Yes |
| 151 | 14075 | 7037.5 | 339.1 | 169.6 | Continuous cultures of fused cells secreting antibody of predefined specificity. | G Kohler, C Milstein | Nature | 1975 | 1172191 | Yes |
| 152 | 7006 | 7006.0 | 640.0 | 640.0 | Hallmarks of Cancer: New Dimensions. | Douglas Hanahan | Cancer Discov | 2022 | 35022204 | No |
| 153 | 6995 | 6995.0 | 317.2 | 317.2 | Executive functions. | Adele Diamond | Annu Rev Psychol | 2013 | 23020641 | No |
| 154 | 41963 | 6993.8 | 1530.6 | 255.1 | Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. | Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde | J Biomed Inform | 2009 | 18929686 | Yes |
| 155 | 6977 | 6977.0 | 177.5 | 177.5 | Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. | J Castresana | Mol Biol Evol | 2000 | 10742046 | Yes |
| 156 | 6906 | 6906.0 | 144.3 | 144.3 | Integrins: bidirectional, allosteric signaling machines. | Richard O Hynes | Cell | 2002 | 12297042 | No |
| 157 | 6885 | 6885.0 | 175.4 | 175.4 | Inflammation and metabolic disorders. | Gokhan S Hotamisligil | Nature | 2006 | 17167474 | No |
| 158 | 6877 | 6877.0 | 187.8 | 187.8 | The steroid and thyroid hormone receptor superfamily. | R M Evans | Science | 1988 | 3283939 | No |
| 159 | 6830 | 6830.0 | 169.7 | 169.7 | Inflammation, atherosclerosis, and coronary artery disease. | Goran K Hansson | N Engl J Med | 2005 | 15843671 | No |
| 160 | 13622 | 6811.0 | 461.9 | 230.9 | The meaning and use of the area under a receiver operating characteristic (ROC) curve. | J A Hanley, B J McNeil | Radiology | 1982 | 7063747 | Yes |
| 161 | 6774 | 6774.0 | 226.6 | 226.6 | Ethical guidelines for investigations of experimental pain in conscious animals. | Manfred Zimmermann | Pain | 1983 | 6877845 | No |
| 162 | 13507 | 6753.5 | 0.0 | 0.0 | Statistical aspects of the analysis of data from retrospective studies of disease. | N Mantel, W Haenszel | J Natl Cancer Inst | 1959 | 13655060 | Yes |
| 163 | 6717 | 6717.0 | 0.0 | 0.0 | The thiobarbituric acid assay of sialic acids. | L Warren | J Biol Chem | 1959 | 13672998 | Yes |
| 164 | 13427 | 6713.5 | 341.5 | 170.8 | Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. | Y Cheng, W H Prusoff | Biochem Pharmacol | 1973 | 4202581 | Yes |
| 165 | 20102 | 6700.7 | 785.6 | 261.9 | Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. | H Ohkawa, N Ohishi, K Yagi | Anal Biochem | 1979 | 36810 | Yes |
| 166 | 26766 | 6691.5 | 801.0 | 200.2 | clusterProfiler: an R package for comparing biological themes among gene clusters. | Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He | OMICS | 2012 | 22455463 | Yes |
| 167 | 13252 | 6626.0 | 531.4 | 265.7 | phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. | Paul J McMurdie, Susan Holmes | PLoS One | 2013 | 23630581 | Yes |
| 168 | 6622 | 6622.0 | 161.0 | 161.0 | Tandem repeats finder: a program to analyze DNA sequences. | G Benson | Nucleic Acids Res | 1999 | 9862982 | Yes |
| 169 | 6622 | 6622.0 | 169.7 | 169.7 | Biochemistry and molecular cell biology of diabetic complications. | M Brownlee | Nature | 2001 | 11742414 | Yes |
| 170 | 19833 | 6611.0 | 573.0 | 191.0 | A new generation of Ca2+ indicators with greatly improved fluorescence properties. | G Grynkiewicz, M Poenie, R Y Tsien | J Biol Chem | 1985 | 3838314 | Yes |
| 171 | 6611 | 6611.0 | 179.0 | 179.0 | Angiogenesis in cancer, vascular, rheumatoid and other disease. | J Folkman | Nat Med | 1995 | 7584949 | No |
| 172 | 19753 | 6584.3 | 631.2 | 210.4 | featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. | Yang Liao, Gordon K Smyth, Wei Shi | Bioinformatics | 2014 | 24227677 | Yes |
| 173 | 13129 | 6564.5 | 430.3 | 215.2 | Prediction of creatinine clearance from serum creatinine. | D W Cockcroft, M H Gault | Nephron | 1976 | 1244564 | Yes |
| 174 | 6548 | 6548.0 | 174.8 | 174.8 | Adhesion receptors of the immune system. | T A Springer | Nature | 1990 | 1974032 | No |
| 175 | 6538 | 6538.0 | 168.1 | 168.1 | Free radicals in the physiological control of cell function. | Wulf Droge | Physiol Rev | 2002 | 11773609 | No |
| 176 | 6512 | 6512.0 | 192.7 | 192.7 | A fast diffeomorphic image registration algorithm. | John Ashburner | Neuroimage | 2007 | 17761438 | Yes |
| 177 | 6510 | 6510.0 | 126.2 | 126.2 | BLAT--the BLAST-like alignment tool. | W James Kent | Genome Res | 2002 | 11932250 | Yes |
| 178 | 6505 | 6505.0 | 152.7 | 152.7 | Inflammation in atherosclerosis. | Peter Libby | Nature | 2002 | 12490960 | No |
| 179 | 6500 | 6500.0 | 256.6 | 256.6 | Whatever happened to qualitative description? | M Sandelowski | Res Nurs Health | 2000 | 10940958 | No |
| 180 | 12980 | 6490.0 | 365.1 | 182.6 | Neuropathological stageing of Alzheimer-related changes. | H Braak, E Braak | Acta Neuropathol | 1991 | 1759558 | No |
| 181 | 6485 | 6485.0 | 143.5 | 143.5 | p53, the cellular gatekeeper for growth and division. | A J Levine | Cell | 1997 | 9039259 | No |
| 182 | 6430 | 6430.0 | 133.0 | 133.0 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel | Proc Natl Acad Sci U S A | 1985 | 3881765 | Yes |
| 183 | 6349 | 6349.0 | 149.2 | 149.2 | MUSCLE: a multiple sequence alignment method with reduced time and space complexity. | Robert C Edgar | BMC Bioinformatics | 2004 | 15318951 | Yes |
| 184 | 12649 | 6324.5 | 296.5 | 148.2 | One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. | K A Datsenko, B L Wanner | Proc Natl Acad Sci U S A | 2000 | 10829079 | Yes |
| 185 | 6314 | 6314.0 | 0.0 | 0.0 | The Environment And Disease: Association Or Causation? | A B Hill | Proc R Soc Med | 1965 | 14283879 | Yes |
| 186 | 6306 | 6306.0 | 159.3 | 159.3 | Antimicrobial peptides of multicellular organisms. | Michael Zasloff | Nature | 2002 | 11807545 | Yes |
| 187 | 12571 | 6285.5 | 292.4 | 146.2 | Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. | W Kabsch, C Sander | Biopolymers | 1983 | 6667333 | Yes |
| 188 | 12499 | 6249.5 | 338.3 | 169.2 | MRBAYES: Bayesian inference of phylogenetic trees. | J P Huelsenbeck, F Ronquist | Bioinformatics | 2001 | 11524383 | Yes |
| 189 | 24952 | 6238.0 | 794.2 | 198.6 | A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. | Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg | J Chem Phys | 2010 | 20423165 | Yes |
| 190 | 6214 | 6214.0 | 142.8 | 142.8 | Modification of seizure activity by electrical stimulation. II. Motor seizure. | R J Racine | Electroencephalogr Clin Neurophysiol | 1972 | 4110397 | Yes |
| 191 | 6178 | 6178.0 | 171.9 | 171.9 | How mitochondria produce reactive oxygen species. | Michael P Murphy | Biochem J | 2009 | 19061483 | No |
| 192 | 12291 | 6145.5 | 351.9 | 175.9 | A rapid alkaline extraction procedure for screening recombinant plasmid DNA. | H C Birnboim, J Doly | Nucleic Acids Res | 1979 | 388356 | Yes |
| 193 | 24487 | 6121.8 | 630.8 | 157.7 | Features and development of Coot. | P Emsley, B Lohkamp, W G Scott, K Cowtan | Acta Crystallogr D Biol Crystallogr | 2010 | 20383002 | Yes |
| 194 | 12212 | 6106.0 | 274.3 | 137.2 | MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. | Jurgen Cox, Matthias Mann | Nat Biotechnol | 2008 | 19029910 | Yes |
| 195 | 6085 | 6085.0 | 158.2 | 158.2 | G proteins: transducers of receptor-generated signals. | A G Gilman | Annu Rev Biochem | 1987 | 3113327 | No |
| 196 | 6064 | 6064.0 | 175.6 | 175.6 | Mild cognitive impairment as a diagnostic entity. | R C Petersen | J Intern Med | 2004 | 15324362 | No |
| 197 | 12115 | 6057.5 | 430.5 | 215.2 | Operating characteristics of a rank correlation test for publication bias. | C B Begg, M Mazumdar | Biometrics | 1994 | 7786990 | Yes |
| 198 | 6053 | 6053.0 | 158.1 | 158.1 | Inositol trisphosphate and calcium signalling. | M J Berridge | Nature | 1993 | 8381210 | No |
| 199 | 6023 | 6023.0 | 224.2 | 224.2 | The need for a new medical model: a challenge for biomedicine. | G L Engel | Science | 1977 | 847460 | Yes |
| 200 | 23960 | 5990.0 | 623.5 | 155.9 | Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. | J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter | Biochemistry | 1979 | 518835 | Yes |
| 201 | 11935 | 5967.5 | 309.2 | 154.6 | Differential expression analysis for sequence count data. | Simon Anders, Wolfgang Huber | Genome Biol | 2010 | 20979621 | Yes |
| 202 | 5952 | 5952.0 | 149.9 | 149.9 | Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. | T A Springer | Cell | 1994 | 7507411 | No |
| 203 | 5944 | 5944.0 | 218.6 | 218.6 | Orienting of attention. | M I Posner | Q J Exp Psychol | 1980 | 7367577 | Yes |
| 204 | 5940 | 5940.0 | 0.0 | 0.0 | Development of a rating scale for primary depressive illness. | M Hamilton | Br J Soc Clin Psychol | 1967 | 6080235 | Yes |
| 205 | 5937 | 5937.0 | 273.5 | 273.5 | Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. | Daniel Lakens | Front Psychol | 2013 | 24324449 | No |
| 206 | 5936 | 5936.0 | 200.2 | 200.2 | jModelTest: phylogenetic model averaging. | David Posada | Mol Biol Evol | 2008 | 18397919 | Yes |
| 207 | 11846 | 5923.0 | 326.4 | 163.2 | Ab initio molecular dynamics for liquid metals. | G Kresse, J Hafner | Phys Rev B Condens Matter | 1993 | 10004490 | Yes |
| 208 | 17729 | 5909.7 | 676.9 | 225.6 | The positive and negative syndrome scale (PANSS) for schizophrenia. | S R Kay, A Fiszbein, L A Opler | Schizophr Bull | 1987 | 3616518 | Yes |
| 209 | 5903 | 5903.0 | 245.3 | 245.3 | Revisiting the behavioral model and access to medical care: does it matter? | R M Andersen | J Health Soc Behav | 1995 | 7738325 | Yes |
| 210 | 11791 | 5895.5 | 267.1 | 133.6 | Inflammation and cancer. | Lisa M Coussens, Zena Werb | Nature | 2002 | 12490959 | No |
| 211 | 17661 | 5887.0 | 722.2 | 240.7 | Deep learning. | Yann LeCun, Yoshua Bengio, Geoffrey Hinton | Nature | 2015 | 26017442 | No |
| 212 | 5863 | 5863.0 | 0.0 | 0.0 | Aging: a theory based on free radical and radiation chemistry. | D Harman | J Gerontol | 1956 | 13332224 | Yes |
| 213 | 11647 | 5823.5 | 429.9 | 214.9 | A new depression scale designed to be sensitive to change. | S A Montgomery, M Asberg | Br J Psychiatry | 1979 | 444788 | Yes |
| 214 | 5756 | 5756.0 | 0.0 | 0.0 | Evaluation of survival data and two new rank order statistics arising in its consideration. | N Mantel | Cancer Chemother Rep | 1966 | 5910392 | Yes |
| 215 | 11512 | 5756.0 | 733.3 | 366.6 | Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. | Zunyou Wu, Jennifer M McGoogan | JAMA | 2020 | 32091533 | Yes |
| 216 | 5749 | 5749.0 | 93.4 | 93.4 | Mutation and cancer: statistical study of retinoblastoma. | A G Knudson | Proc Natl Acad Sci U S A | 1971 | 5279523 | Yes |
| 217 | 5737 | 5737.0 | 150.1 | 150.1 | Apoptosis in the pathogenesis and treatment of disease. | C B Thompson | Science | 1995 | 7878464 | No |
| 218 | 11466 | 5733.0 | 0.0 | 0.0 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. | T Omura, R Sato | J Biol Chem | 1964 | 14209971 | Yes |
| 219 | 11447 | 5723.5 | 0.0 | 0.0 | A series of normal stages in the development of the chick embryo. | V Hamburger, H L Hamilton | J Morphol | 1951 | 24539719 | Yes |
| 220 | 17125 | 5708.3 | 696.9 | 232.3 | A global measure of perceived stress. | S Cohen, T Kamarck, R Mermelstein | J Health Soc Behav | 1983 | 6668417 | Yes |
| 221 | 11372 | 5686.0 | 464.3 | 232.2 | Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. | U H Graneheim, B Lundman | Nurse Educ Today | 2004 | 14769454 | No |
| 222 | 11327 | 5663.5 | 284.9 | 142.4 | A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. | Stephane Guindon, Olivier Gascuel | Syst Biol | 2003 | 14530136 | Yes |
| 223 | 5652 | 5652.0 | 173.0 | 173.0 | Developments of a water-maze procedure for studying spatial learning in the rat. | R Morris | J Neurosci Methods | 1984 | 6471907 | Yes |
| 224 | 16940 | 5646.7 | 622.0 | 207.3 | HISAT: a fast spliced aligner with low memory requirements. | Daehwan Kim, Ben Langmead, Steven L Salzberg | Nat Methods | 2015 | 25751142 | Yes |
| 225 | 5640 | 5640.0 | 0.0 | 0.0 | Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. | F Tietze | Anal Biochem | 1969 | 4388022 | Yes |
| 226 | 16878 | 5626.0 | 466.8 | 155.6 | Inference of population structure using multilocus genotype data. | J K Pritchard, M Stephens, P Donnelly | Genetics | 2000 | 10835412 | Yes |
| 227 | 16835 | 5611.7 | 519.3 | 173.1 | A simple salting out procedure for extracting DNA from human nucleated cells. | S A Miller, D D Dykes, H F Polesky | Nucleic Acids Res | 1988 | 3344216 | Yes |
| 228 | 5606 | 5606.0 | 131.7 | 131.7 | The biochemistry of apoptosis. | M O Hengartner | Nature | 2000 | 11048727 | No |
| 229 | 11211 | 5605.5 | 0.0 | 0.0 | A quantitative description of membrane current and its application to conduction and excitation in nerve. | A L Hodgkin, A F Huxley | J Physiol | 1952 | 12991237 | Yes |
| 230 | 11030 | 5515.0 | 253.3 | 126.7 | Dendritic cells and the control of immunity. | J Banchereau, R M Steinman | Nature | 1998 | 9521319 | No |
| 231 | 21976 | 5494.0 | 774.0 | 193.5 | A brief measure for assessing generalized anxiety disorder: the GAD-7. | Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Lowe | Arch Intern Med | 2006 | 16717171 | Yes |
| 232 | 5485 | 5485.0 | 0.0 | 0.0 | The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. | P Lauren | Acta Pathol Microbiol Scand | 1965 | 14320675 | Yes |
| 233 | 5478 | 5478.0 | 111.5 | 111.5 | Epithelial-mesenchymal transitions in tumour progression. | Jean Paul Thiery | Nat Rev Cancer | 2002 | 12189386 | No |
| 234 | 10932 | 5466.0 | 263.4 | 131.7 | Sequencing end-labeled DNA with base-specific chemical cleavages. | A M Maxam, W Gilbert | Methods Enzymol | 1980 | 6246368 | Yes |
| 235 | 10906 | 5453.0 | 253.8 | 126.9 | The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. | John Hardy, Dennis J Selkoe | Science | 2002 | 12130773 | No |
| 236 | 5447 | 5447.0 | 183.6 | 183.6 | Updating P300: an integrative theory of P3a and P3b. | John Polich | Clin Neurophysiol | 2007 | 17573239 | No |
| 237 | 5445 | 5445.0 | 146.5 | 146.5 | Emotion circuits in the brain. | J E LeDoux | Annu Rev Neurosci | 2000 | 10845062 | No |
| 238 | 5431 | 5431.0 | 112.5 | 112.5 | Targeting HIF-1 for cancer therapy. | Gregg L Semenza | Nat Rev Cancer | 2003 | 13130303 | No |
| 239 | 10847 | 5423.5 | 336.0 | 168.0 | MODELTEST: testing the model of DNA substitution. | D Posada, K A Crandall | Bioinformatics | 1998 | 9918953 | Yes |
| 240 | 5411 | 5411.0 | 157.7 | 157.7 | The Cambridge Structural Database: a quarter of a million crystal structures and rising. | Frank H Allen | Acta Crystallogr B | 2002 | 12037359 | Yes |
| 241 | 16179 | 5393.0 | 557.7 | 185.9 | HTSeq--a Python framework to work with high-throughput sequencing data. | Simon Anders, Paul Theodor Pyl, Wolfgang Huber | Bioinformatics | 2015 | 25260700 | Yes |
| 242 | 10784 | 5392.0 | 264.6 | 132.3 | Comparative protein modelling by satisfaction of spatial restraints. | A Sali, T L Blundell | J Mol Biol | 1993 | 8254673 | Yes |
| 243 | 26955 | 5391.0 | 791.5 | 158.3 | The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. | J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins | Nucleic Acids Res | 1997 | 9396791 | Yes |
| 244 | 10747 | 5373.5 | 420.6 | 210.3 | Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods | 2008 | 18697684 | Yes |
| 245 | 10733 | 5366.5 | 0.0 | 0.0 | Functional Evaluation: The Barthel Index. | F I Mahoney, D W Barthel | Md State Med J | 1965 | 14258950 | Yes |
| 246 | 10705 | 5352.5 | 0.0 | 0.0 | Assessment of older people: self-maintaining and instrumental activities of daily living. | M P Lawton, E M Brody | Gerontologist | 1969 | 5349366 | Yes |
| 247 | 5310 | 5310.0 | 138.5 | 138.5 | New M13 vectors for cloning. | J Messing | Methods Enzymol | 1983 | 6310323 | Yes |
| 248 | 5262 | 5262.0 | 131.8 | 131.8 | The NF-kappa B and I kappa B proteins: new discoveries and insights. | A S Baldwin | Annu Rev Immunol | 1996 | 8717528 | No |
| 249 | 5257 | 5257.0 | 157.8 | 157.8 | Studies and perspectives of protein kinase C. | Y Nishizuka | Science | 1986 | 3014651 | No |
| 250 | 5243 | 5243.0 | 196.4 | 196.4 | Oxygen-derived free radicals in postischemic tissue injury. | J M McCord | N Engl J Med | 1985 | 2981404 | No |
| 251 | 5221 | 5221.0 | 0.0 | 0.0 | [A micro-method of immuno-electrophoresis]. | J J Scheidegger | Int Arch Allergy Appl Immunol | 1955 | 13262900 | Yes |
| 252 | 5211 | 5211.0 | 0.0 | 0.0 | Selective extraction of polyoma DNA from infected mouse cell cultures. | B Hirt | J Mol Biol | 1967 | 4291934 | Yes |
| 253 | 10411 | 5205.5 | 338.3 | 169.2 | The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. | R F Furchgott, J V Zawadzki | Nature | 1980 | 6253831 | Yes |
| 254 | 10409 | 5204.5 | 291.6 | 145.8 | The rise of graphene. | A K Geim, K S Novoselov | Nat Mater | 2007 | 17330084 | Yes |
| 255 | 26002 | 5200.4 | 1100.2 | 220.0 | MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. | Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar | Mol Biol Evol | 2013 | 24132122 | Yes |
| 256 | 15562 | 5187.3 | 500.6 | 166.9 | Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. | E R DeLong, D M DeLong, D L Clarke-Pearson | Biometrics | 1988 | 3203132 | Yes |
| 257 | 5179 | 5179.0 | 106.8 | 106.8 | Rho GTPases and the actin cytoskeleton. | A Hall | Science | 1998 | 9438836 | No |
| 258 | 15466 | 5155.3 | 701.8 | 233.9 | Development and validation of brief measures of positive and negative affect: the PANAS scales. | D Watson, L A Clark, A Tellegen | J Pers Soc Psychol | 1988 | 3397865 | Yes |
| 259 | 5151 | 5151.0 | 0.0 | 0.0 | Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. | W H Harris | J Bone Joint Surg Am | 1969 | 5783851 | Yes |
| 260 | 10298 | 5149.0 | 284.2 | 142.1 | Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. | H Schagger, G Von Jagow | Anal Biochem | 1987 | 2449095 | Yes |
| 261 | 5140 | 5140.0 | 201.4 | 201.4 | Analyzing Tables Of Statistical Tests. | William R Rice | Evolution | 1989 | 28568501 | Yes |
| 262 | 10279 | 5139.5 | 245.8 | 122.9 | A genetic model for colorectal tumorigenesis. | E R Fearon, B Vogelstein | Cell | 1990 | 2188735 | No |
| 263 | 5132 | 5132.0 | 94.8 | 94.8 | The clonal evolution of tumor cell populations. | P C Nowell | Science | 1976 | 959840 | Yes |
| 264 | 10261 | 5130.5 | 274.7 | 137.3 | Long short-term memory. | S Hochreiter, J Schmidhuber | Neural Comput | 1997 | 9377276 | Yes |
| 265 | 5119 | 5119.0 | 98.8 | 98.8 | DNA methylation patterns and epigenetic memory. | Adrian Bird | Genes Dev | 2002 | 11782440 | No |
| 266 | 5113 | 5113.0 | 128.6 | 128.6 | Why most published research findings are false. | John P A Ioannidis | PLoS Med | 2005 | 16060722 | Yes |
| 267 | 25558 | 5111.6 | 0.0 | 0.0 | An inventory for measuring depression. | A T Beck, C H Ward, M Mendelson, J Mock, J Erbaugh | Arch Gen Psychiatry | 1961 | 13688369 | Yes |
| 268 | 10177 | 5088.5 | 418.5 | 209.2 | The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. | I F Benzie, J J Strain | Anal Biochem | 1996 | 8660627 | Yes |
| 269 | 10096 | 5048.0 | 0.0 | 0.0 | Parkinsonism: onset, progression and mortality. | M M Hoehn, M D Yahr | Neurology | 1967 | 6067254 | Yes |
| 270 | 10096 | 5048.0 | 433.1 | 216.6 | The qualitative content analysis process. | Satu Elo, Helvi Kyngas | J Adv Nurs | 2008 | 18352969 | Yes |
| 271 | 5047 | 5047.0 | 148.2 | 148.2 | Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. | Peter C Austin | Stat Med | 2009 | 19757444 | Yes |
| 272 | 5041 | 5041.0 | 153.2 | 153.2 | DNA methylation age of human tissues and cell types. | Steve Horvath | Genome Biol | 2013 | 24138928 | Yes |
| 273 | 35238 | 5034.0 | 826.3 | 118.0 | UCSF Chimera--a visualization system for exploratory research and analysis. | Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin | J Comput Chem | 2004 | 15264254 | Yes |
| 274 | 20123 | 5030.8 | 0.0 | 0.0 | A new and rapid colorimetric determination of acetylcholinesterase activity. | G L Ellman, K D Courtney, V Andres, R M Feather-Stone | Biochem Pharmacol | 1961 | 13726518 | Yes |
| 275 | 10030 | 5015.0 | 440.5 | 220.2 | The timed "Up & Go": a test of basic functional mobility for frail elderly persons. | D Podsiadlo, S Richardson | J Am Geriatr Soc | 1991 | 1991946 | Yes |
| 276 | 15006 | 5002.0 | 554.0 | 184.7 | Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. | S M Hsu, L Raine, H Fanger | J Histochem Cytochem | 1981 | 6166661 | Yes |
| 277 | 24932 | 4986.4 | 1000.4 | 200.1 | The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. | D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer | Psychiatry Res | 1989 | 2748771 | Yes |
| 278 | 9925 | 4962.5 | 252.6 | 126.3 | Collective dynamics of 'small-world' networks. | D J Watts, S H Strogatz | Nature | 1998 | 9623998 | Yes |
| 279 | 4947 | 4947.0 | 162.6 | 162.6 | A protein binding assay for adenosine 3':5'-cyclic monophosphate. | A G Gilman | Proc Natl Acad Sci U S A | 1970 | 4318781 | Yes |
| 280 | 4911 | 4911.0 | 0.0 | 0.0 | Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. | C B Laurell | Anal Biochem | 1966 | 5959431 | Yes |
| 281 | 4904 | 4904.0 | 101.5 | 101.5 | An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. | M Kozak | Nucleic Acids Res | 1987 | 3313277 | No |
| 282 | 4903 | 4903.0 | 208.4 | 208.4 | The McGill Pain Questionnaire: major properties and scoring methods. | Ronald Melzack | Pain | 1975 | 1235985 | Yes |
| 283 | 9780 | 4890.0 | 312.5 | 156.2 | Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. | S Duval, R Tweedie | Biometrics | 2000 | 10877304 | Yes |
| 284 | 14667 | 4889.0 | 406.4 | 135.5 | Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. | C Yanisch-Perron, J Vieira, J Messing | Gene | 1985 | 2985470 | Yes |
| 285 | 9776 | 4888.0 | 324.8 | 162.4 | Ligand: a versatile computerized approach for characterization of ligand-binding systems. | P J Munson, D Rodbard | Anal Biochem | 1980 | 6254391 | Yes |
| 286 | 4880 | 4880.0 | 115.8 | 115.8 | Alzheimer's disease: genes, proteins, and therapy. | D J Selkoe | Physiol Rev | 2001 | 11274343 | No |
| 287 | 9716 | 4858.0 | 322.9 | 161.4 | FLASH: fast length adjustment of short reads to improve genome assemblies. | Tanja Magoc, Steven L Salzberg | Bioinformatics | 2011 | 21903629 | Yes |
| 288 | 4858 | 4858.0 | 139.7 | 139.7 | Accelerated Profile HMM Searches. | Sean R Eddy | PLoS Comput Biol | 2011 | 22039361 | Yes |
| 289 | 4856 | 4856.0 | 0.0 | 0.0 | The Limited In Vitro Lifetime Of Human Diploid Cell Strains. | L Hayflick | Exp Cell Res | 1965 | 14315085 | Yes |
| 290 | 14549 | 4849.7 | 0.0 | 0.0 | Determination of serum proteins by means of the biuret reaction. | A G Gornall, C J Bardawill, M M David | J Biol Chem | 1949 | 18110453 | Yes |
| 291 | 9690 | 4845.0 | 0.0 | 0.0 | Radiological assessment of osteo-arthrosis. | J H Kellgren, J S Lawrence | Ann Rheum Dis | 1957 | 13498604 | Yes |
| 292 | 4839 | 4839.0 | 179.2 | 179.2 | Emerging adulthood. A theory of development from the late teens through the twenties. | J J Arnett | Am Psychol | 2000 | 10842426 | Yes |
| 293 | 19348 | 4837.0 | 902.9 | 225.7 | fastp: an ultra-fast all-in-one FASTQ preprocessor. | Shifu Chen, Yanqing Zhou, Yaru Chen, Jia Gu | Bioinformatics | 2018 | 30423086 | Yes |
| 294 | 4836 | 4836.0 | 110.8 | 110.8 | ras oncogenes in human cancer: a review. | J L Bos | Cancer Res | 1989 | 2547513 | No |
| 295 | 4833 | 4833.0 | 112.2 | 112.2 | Prions. | S B Prusiner | Proc Natl Acad Sci U S A | 1998 | 9811807 | No |
| 296 | 4830 | 4830.0 | 108.6 | 108.6 | Cancer cell cycles. | C J Sherr | Science | 1996 | 8939849 | No |
| 297 | 14442 | 4814.0 | 330.0 | 110.0 | Refinement of macromolecular structures by the maximum-likelihood method. | G N Murshudov, A A Vagin, E J Dodson | Acta Crystallogr D Biol Crystallogr | 1997 | 15299926 | Yes |
| 298 | 14439 | 4813.0 | 371.9 | 124.0 | A comprehensive set of sequence analysis programs for the VAX. | J Devereux, P Haeberli, O Smithies | Nucleic Acids Res | 1984 | 6546423 | Yes |
| 299 | 4809 | 4809.0 | 0.0 | 0.0 | Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. | M Rodbell | J Biol Chem | 1964 | 14169133 | Yes |
| 300 | 4771 | 4771.0 | 105.1 | 105.1 | Protein production by auto-induction in high density shaking cultures. | F William Studier | Protein Expr Purif | 2005 | 15915565 | Yes |
| 301 | 9530 | 4765.0 | 174.4 | 87.2 | A new technique for the assay of infectivity of human adenovirus 5 DNA. | F L Graham, A J Van Der Eb | Virology | 1973 | 4705382 | Yes |
| 302 | 4764 | 4764.0 | 183.7 | 183.7 | Measuring the accuracy of diagnostic systems. | J A Swets | Science | 1988 | 3287615 | No |
| 303 | 9491 | 4745.5 | 336.8 | 168.4 | Assessment of coma and impaired consciousness. A practical scale. | G Teasdale, B Jennett | Lancet | 1974 | 4136544 | Yes |
| 304 | 9489 | 4744.5 | 242.3 | 121.2 | Improved tools for biological sequence comparison. | W R Pearson, D J Lipman | Proc Natl Acad Sci U S A | 1988 | 3162770 | Yes |
| 305 | 4741 | 4741.0 | 101.3 | 101.3 | Alternative activation of macrophages. | Siamon Gordon | Nat Rev Immunol | 2003 | 12511873 | No |
| 306 | 4725 | 4725.0 | 130.7 | 130.7 | Accurate Coulomb-fitting basis sets for H to Rn. | Florian Weigend | Phys Chem Chem Phys | 2006 | 16633586 | Yes |
| 307 | 4722 | 4722.0 | 0.0 | 0.0 | Aggregation of blood platelets by adenosine diphosphate and its reversal. | G V Born | Nature | 1962 | 13871375 | Yes |
| 308 | 4716 | 4716.0 | 0.0 | 0.0 | The genetical evolution of social behaviour. I. | W D Hamilton | J Theor Biol | 1964 | 5875341 | Yes |
| 309 | 9431 | 4715.5 | 0.0 | 0.0 | Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). | J M McCord, I Fridovich | J Biol Chem | 1969 | 5389100 | Yes |
| 310 | 4705 | 4705.0 | 162.8 | 162.8 | The pathogenesis of atherosclerosis--an update. | R Ross | N Engl J Med | 1986 | 3511384 | No |
| 311 | 4693 | 4693.0 | 187.2 | 187.2 | EuroQol: the current state of play. | R Brooks | Health Policy | 1996 | 10158943 | No |
| 312 | 14061 | 4687.0 | 574.4 | 191.5 | A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. | J Ware, M Kosinski, S D Keller | Med Care | 1996 | 8628042 | Yes |
| 313 | 9372 | 4686.0 | 279.6 | 139.8 | Estimating F-Statistics For The Analysis Of Population Structure. | B S Weir, C Clark Cockerham | Evolution | 1984 | 28563791 | Yes |
| 314 | 18735 | 4683.8 | 576.3 | 144.1 | MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. | Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2007 | 17488738 | Yes |
| 315 | 4682 | 4682.0 | 135.0 | 135.0 | Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. | P Matsudaira | J Biol Chem | 1987 | 3611052 | Yes |
| 316 | 4677 | 4677.0 | 124.2 | 124.2 | A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. | Heng Li | Bioinformatics | 2011 | 21903627 | Yes |
| 317 | 4674 | 4674.0 | 117.5 | 117.5 | A rapid banding technique for human chromosomes. | M Seabright | Lancet | 1971 | 4107917 | Yes |
| 318 | 4666 | 4666.0 | 99.5 | 99.5 | Wnt/beta-catenin signaling in development and disease. | Hans Clevers | Cell | 2006 | 17081971 | No |
| 319 | 4650 | 4650.0 | 119.0 | 119.0 | Origin and physiological roles of inflammation. | Ruslan Medzhitov | Nature | 2008 | 18650913 | No |
| 320 | 9295 | 4647.5 | 226.3 | 113.2 | Primer3 on the WWW for general users and for biologist programmers. | S Rozen, H Skaletsky | Methods Mol Biol | 2000 | 10547847 | Yes |
| 321 | 4644 | 4644.0 | 151.4 | 151.4 | How do you feel--now? The anterior insula and human awareness. | A D Bud Craig | Nat Rev Neurosci | 2009 | 19096369 | No |
| 322 | 4633 | 4633.0 | 108.7 | 108.7 | Cancer. p53, guardian of the genome. | D P Lane | Nature | 1992 | 1614522 | No |
| 323 | 4626 | 4626.0 | 123.8 | 123.8 | Drug combination studies and their synergy quantification using the Chou-Talalay method. | Ting-Chao Chou | Cancer Res | 2010 | 20068163 | Yes |
| 324 | 9250 | 4625.0 | 230.5 | 115.2 | Fast and accurate long-read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2010 | 20080505 | Yes |
| 325 | 4610 | 4610.0 | 176.2 | 176.2 | A concordance correlation coefficient to evaluate reproducibility. | L I Lin | Biometrics | 1989 | 2720055 | Yes |
| 326 | 4607 | 4607.0 | 153.8 | 153.8 | Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). | Gunther Eysenbach | J Med Internet Res | 2004 | 15471760 | No |
| 327 | 9180 | 4590.0 | 225.5 | 112.8 | SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. | N Guex, M C Peitsch | Electrophoresis | 1997 | 9504803 | Yes |
| 328 | 9177 | 4588.5 | 255.5 | 127.8 | A synaptic model of memory: long-term potentiation in the hippocampus. | T V Bliss, G L Collingridge | Nature | 1993 | 8421494 | No |
| 329 | 4587 | 4587.0 | 0.0 | 0.0 | The detection of disease clustering and a generalized regression approach. | N Mantel | Cancer Res | 1967 | 6018555 | Yes |
| 330 | 13744 | 4581.3 | 504.1 | 168.0 | Nitric oxide: physiology, pathophysiology, and pharmacology. | S Moncada, R M Palmer, E A Higgs | Pharmacol Rev | 1991 | 1852778 | No |
| 331 | 4561 | 4561.0 | 100.8 | 100.8 | ras genes. | M Barbacid | Annu Rev Biochem | 1987 | 3304147 | No |
| 332 | 4561 | 4561.0 | 0.0 | 0.0 | New methods for calculating metabolic rate with special reference to protein metabolism. | J B de B Weir | J Physiol | 1949 | 15394301 | Yes |
| 333 | 4551 | 4551.0 | 90.9 | 90.9 | The phosphoinositide 3-kinase pathway. | Lewis C Cantley | Science | 2002 | 12040186 | No |
| 334 | 4547 | 4547.0 | 95.2 | 95.2 | Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. | M Kozak | Cell | 1986 | 3943125 | Yes |
| 335 | 4536 | 4536.0 | 100.8 | 100.8 | Folding DNA to create nanoscale shapes and patterns. | Paul W K Rothemund | Nature | 2006 | 16541064 | Yes |
| 336 | 4534 | 4534.0 | 0.0 | 0.0 | Evolution in Mendelian Populations. | S Wright | Genetics | 1931 | 17246615 | Yes |
| 337 | 27201 | 4533.5 | 905.7 | 151.0 | Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. | D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner | Diabetologia | 1985 | 3899825 | Yes |
| 338 | 45276 | 4527.6 | 1181.3 | 118.1 | The Sequence Alignment/Map format and SAMtools. | Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin, | Bioinformatics | 2009 | 19505943 | Yes |
| 339 | 22617 | 4523.4 | 1345.4 | 269.1 | MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. | Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura | Mol Biol Evol | 2018 | 29722887 | Yes |
| 340 | 4512 | 4512.0 | 166.9 | 166.9 | KDIGO clinical practice guidelines for acute kidney injury. | Arif Khwaja | Nephron Clin Pract | 2012 | 22890468 | No |
| 341 | 4462 | 4462.0 | 125.0 | 125.0 | Staphylococcus aureus infections. | F D Lowy | N Engl J Med | 1998 | 9709046 | No |
| 342 | 8902 | 4451.0 | 256.8 | 128.4 | Control of goal-directed and stimulus-driven attention in the brain. | Maurizio Corbetta, Gordon L Shulman | Nat Rev Neurosci | 2002 | 11994752 | No |
| 343 | 26680 | 4446.7 | 984.7 | 164.1 | MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. | Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2011 | 21546353 | Yes |
| 344 | 8883 | 4441.5 | 0.0 | 0.0 | A simplified method of evaluating dose-effect experiments. | J T Litchfield, F Wilcoxon | J Pharmacol Exp Ther | 1949 | 18152921 | Yes |
| 345 | 4441 | 4441.0 | 103.7 | 103.7 | Atherosclerosis. | A J Lusis | Nature | 2000 | 11001066 | No |
| 346 | 4437 | 4437.0 | 122.4 | 122.4 | Functions of DNA methylation: islands, start sites, gene bodies and beyond. | Peter A Jones | Nat Rev Genet | 2012 | 22641018 | No |
| 347 | 4435 | 4435.0 | 112.1 | 112.1 | A new method for predicting signal sequence cleavage sites. | G Von Heijne | Nucleic Acids Res | 1986 | 3714490 | Yes |
| 348 | 4435 | 4435.0 | 109.6 | 109.6 | Mechanisms of angiogenesis. | W Risau | Nature | 1997 | 9109485 | No |
| 349 | 8861 | 4430.5 | 244.1 | 122.0 | tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. | T M Lowe, S R Eddy | Nucleic Acids Res | 1997 | 9023104 | Yes |
| 350 | 4430 | 4430.0 | 0.0 | 0.0 | The Scree Test For The Number Of Factors. | R B Cattell | Multivariate Behav Res | 1966 | 26828106 | Yes |
| 351 | 4425 | 4425.0 | 108.7 | 108.7 | RELION: implementation of a Bayesian approach to cryo-EM structure determination. | Sjors H W Scheres | J Struct Biol | 2012 | 23000701 | Yes |
| 352 | 4411 | 4411.0 | 126.0 | 126.0 | Oxidative stress, antioxidants and stress tolerance. | Ron Mittler | Trends Plant Sci | 2002 | 12234732 | No |
| 353 | 17641 | 4410.2 | 680.2 | 170.1 | Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. | Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang | Behav Res Methods | 2009 | 19897823 | Yes |
| 354 | 8815 | 4407.5 | 294.0 | 147.0 | DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. | P Librado, J Rozas | Bioinformatics | 2009 | 19346325 | Yes |
| 355 | 8772 | 4386.0 | 236.2 | 118.1 | A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. | W M Bonner, R A Laskey | Eur J Biochem | 1974 | 4850204 | Yes |
| 356 | 4363 | 4363.0 | 0.0 | 0.0 | Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. | J Cohen | Psychol Bull | 1968 | 19673146 | Yes |
| 357 | 8715 | 4357.5 | 0.0 | 0.0 | Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. | D E Paglia, W N Valentine | J Lab Clin Med | 1967 | 6066618 | Yes |
| 358 | 4357 | 4357.0 | 170.7 | 170.7 | Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. | M M Mesulam | J Histochem Cytochem | 1978 | 24068 | Yes |
| 359 | 8706 | 4353.0 | 196.4 | 98.2 | Inference of macromolecular assemblies from crystalline state. | Evgeny Krissinel, Kim Henrick | J Mol Biol | 2007 | 17681537 | Yes |
| 360 | 4346 | 4346.0 | 131.7 | 131.7 | Glutamate neurotoxicity and diseases of the nervous system. | D W Choi | Neuron | 1988 | 2908446 | No |
| 361 | 4344 | 4344.0 | 77.6 | 77.6 | Automated electron microscope tomography using robust prediction of specimen movements. | David N Mastronarde | J Struct Biol | 2005 | 16182563 | Yes |
| 362 | 4339 | 4339.0 | 113.2 | 113.2 | The origins and the future of microfluidics. | George M Whitesides | Nature | 2006 | 16871203 | No |
| 363 | 4338 | 4338.0 | 101.0 | 101.0 | PAML: a program package for phylogenetic analysis by maximum likelihood. | Z Yang | Comput Appl Biosci | 1997 | 9367129 | Yes |
| 364 | 4335 | 4335.0 | 116.5 | 116.5 | Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. | Y Nishizuka | Science | 1992 | 1411571 | No |
| 365 | 4322 | 4322.0 | 175.9 | 175.9 | A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. | E Pfeiffer | J Am Geriatr Soc | 1975 | 1159263 | Yes |
| 366 | 4319 | 4319.0 | 127.1 | 127.1 | Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. | D Vanderbilt | Phys Rev B Condens Matter | 1990 | 9993096 | Yes |
| 367 | 8616 | 4308.0 | 219.8 | 109.9 | The plant immune system. | Jonathan D G Jones, Jeffery L Dangl | Nature | 2006 | 17108957 | No |
| 368 | 4305 | 4305.0 | 82.0 | 82.0 | Principles that govern the folding of protein chains. | C B Anfinsen | Science | 1973 | 4124164 | Yes |
| 369 | 4294 | 4294.0 | 136.3 | 136.3 | EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. | W Klimesch | Brain Res Brain Res Rev | 1999 | 10209231 | No |
| 370 | 4292 | 4292.0 | 90.4 | 90.4 | The retinoblastoma protein and cell cycle control. | R A Weinberg | Cell | 1995 | 7736585 | No |
| 371 | 8584 | 4292.0 | 0.0 | 0.0 | Preparation of iodine-131 labelled human growth hormone of high specific activity. | W M Hunter, F C Greenwood | Nature | 1962 | 14450081 | Yes |
| 372 | 4290 | 4290.0 | 0.0 | 0.0 | Estimation of nuclear population from microtome sections. | M Abercrombie | Anat Rec | 1946 | 21015608 | Yes |
| 373 | 4287 | 4287.0 | 164.0 | 164.0 | Observational study of behavior: sampling methods. | J Altmann | Behaviour | 1974 | 4597405 | No |
| 374 | 4284 | 4284.0 | 79.4 | 79.4 | Generalized lacZ expression with the ROSA26 Cre reporter strain. | P Soriano | Nat Genet | 1999 | 9916792 | Yes |
| 375 | 4283 | 4283.0 | 94.3 | 94.3 | Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. | Rakesh K Jain | Science | 2005 | 15637262 | No |
| 376 | 4279 | 4279.0 | 92.0 | 92.0 | The green fluorescent protein. | R Y Tsien | Annu Rev Biochem | 1998 | 9759496 | No |
| 377 | 4277 | 4277.0 | 87.3 | 87.3 | Hypoxia--a key regulatory factor in tumour growth. | Adrian L Harris | Nat Rev Cancer | 2002 | 11902584 | No |
| 378 | 38488 | 4276.4 | 1211.4 | 134.6 | STAR: ultrafast universal RNA-seq aligner. | Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras | Bioinformatics | 2013 | 23104886 | Yes |
| 379 | 4267 | 4267.0 | 115.2 | 115.2 | The molecular heterogeneity of protein kinase C and its implications for cellular regulation. | Y Nishizuka | Nature | 1988 | 3045562 | No |
| 380 | 4263 | 4263.0 | 0.0 | 0.0 | Bone: formation by autoinduction. | M R Urist | Science | 1965 | 5319761 | Yes |
| 381 | 4262 | 4262.0 | 0.0 | 0.0 | The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. | T Nash | Biochem J | 1953 | 13105648 | Yes |
| 382 | 29807 | 4258.1 | 1077.3 | 153.9 | limma powers differential expression analyses for RNA-sequencing and microarray studies. | Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth | Nucleic Acids Res | 2015 | 25605792 | Yes |
| 383 | 4256 | 4256.0 | 0.0 | 0.0 | Amino acid metabolism in mammalian cell cultures. | H Eagle | Science | 1959 | 13675766 | Yes |
| 384 | 4233 | 4233.0 | 96.2 | 96.2 | Apoptosis by death factor. | S Nagata | Cell | 1997 | 9039262 | No |
| 385 | 4232 | 4232.0 | 100.4 | 100.4 | Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. | A H Wyllie | Nature | 1980 | 6245367 | Yes |
| 386 | 12674 | 4224.7 | 466.9 | 155.6 | Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. | W H Habig, M J Pabst, W B Jakoby | J Biol Chem | 1974 | 4436300 | Yes |
| 387 | 4224 | 4224.0 | 134.0 | 134.0 | Determination of protein: a modification of the Lowry method that gives a linear photometric response. | E F Hartree | Anal Biochem | 1972 | 4115981 | Yes |
| 388 | 16894 | 4223.5 | 400.7 | 100.2 | Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. | Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg | Genome Biol | 2009 | 19261174 | Yes |
| 389 | 4222 | 4222.0 | 97.9 | 97.9 | Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. | S Henikoff | Gene | 1984 | 6235151 | Yes |
| 390 | 4218 | 4218.0 | 118.9 | 118.9 | Mesenchymal stem cells. | A I Caplan | J Orthop Res | 1991 | 1870029 | Yes |
| 391 | 12631 | 4210.3 | 419.7 | 139.9 | Effect of the damping function in dispersion corrected density functional theory. | Stefan Grimme, Stephan Ehrlich, Lars Goerigk | J Comput Chem | 2011 | 21370243 | Yes |
| 392 | 8409 | 4204.5 | 237.3 | 118.7 | Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. | Daniel E Voth, Robert A Heinzen | Cell Microbiol | 2007 | 17381428 | No |
| 393 | 4202 | 4202.0 | 115.1 | 115.1 | Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? | Kim A Brogden | Nat Rev Microbiol | 2005 | 15703760 | No |
| 394 | 4201 | 4201.0 | 0.0 | 0.0 | A relation between non-esterified fatty acids in plasma and the metabolism of glucose. | V P Dole | J Clin Invest | 1956 | 13286333 | Yes |
| 395 | 4200 | 4200.0 | 89.4 | 89.4 | Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. | C J Marshall | Cell | 1995 | 7834738 | No |
| 396 | 16748 | 4187.0 | 713.8 | 178.4 | IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. | Lam-Tung Nguyen, Heiko A Schmidt, Arndt Von Haeseler, Bui Quang Minh | Mol Biol Evol | 2015 | 25371430 | Yes |
| 397 | 4179 | 4179.0 | 131.9 | 131.9 | adegenet: a R package for the multivariate analysis of genetic markers. | Thibaut Jombart | Bioinformatics | 2008 | 18397895 | Yes |
| 398 | 4171 | 4171.0 | 0.0 | 0.0 | The determination of enzyme inhibitor constants. | M Dixon | Biochem J | 1953 | 13093635 | Yes |
| 399 | 4170 | 4170.0 | 172.7 | 172.7 | You want to measure coping but your protocol's too long: consider the brief COPE. | C S Carver | Int J Behav Med | 1997 | 16250744 | Yes |
| 400 | 8325 | 4162.5 | 231.5 | 115.8 | An integrative theory of prefrontal cortex function. | E K Miller, J D Cohen | Annu Rev Neurosci | 2001 | 11283309 | No |
| 401 | 12486 | 4162.0 | 1161.7 | 387.2 | MEGA11: Molecular Evolutionary Genetics Analysis Version 11. | Koichiro Tamura, Glen Stecher, Sudhir Kumar | Mol Biol Evol | 2021 | 33892491 | Yes |
| 402 | 12483 | 4161.0 | 313.2 | 104.4 | Understanding the Warburg effect: the metabolic requirements of cell proliferation. | Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson | Science | 2009 | 19460998 | No |
| 403 | 4159 | 4159.0 | 133.5 | 133.5 | Bacterial evolution. | C R Woese | Microbiol Rev | 1987 | 2439888 | No |
| 404 | 8317 | 4158.5 | 214.1 | 107.0 | The basics of epithelial-mesenchymal transition. | Raghu Kalluri, Robert A Weinberg | J Clin Invest | 2009 | 19487818 | No |
| 405 | 4158 | 4158.0 | 155.2 | 155.2 | Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. | Russell A Barkley | Psychol Bull | 1997 | 9000892 | No |
| 406 | 4156 | 4156.0 | 103.7 | 103.7 | Multiple sequence alignment with hierarchical clustering. | F Corpet | Nucleic Acids Res | 1988 | 2849754 | Yes |
| 407 | 4154 | 4154.0 | 102.1 | 102.1 | Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. | Ting-Chao Chou | Pharmacol Rev | 2006 | 16968952 | No |
| 408 | 8281 | 4140.5 | 185.3 | 92.7 | Genomic sequencing. | G M Church, W Gilbert | Proc Natl Acad Sci U S A | 1984 | 6326095 | Yes |
| 409 | 4137 | 4137.0 | 219.1 | 219.1 | High-performance medicine: the convergence of human and artificial intelligence. | Eric J Topol | Nat Med | 2019 | 30617339 | No |
| 410 | 16469 | 4117.2 | 971.7 | 242.9 | Rayyan-a web and mobile app for systematic reviews. | Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed Elmagarmid | Syst Rev | 2016 | 27919275 | Yes |
| 411 | 8228 | 4114.0 | 468.2 | 234.1 | The biology, function, and biomedical applications of exosomes. | Raghu Kalluri, Valerie S LeBleu | Science | 2020 | 32029601 | No |
| 412 | 4109 | 4109.0 | 117.7 | 117.7 | Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. | R B D'Agostino | Stat Med | 1998 | 9802183 | Yes |
| 413 | 36963 | 4107.0 | 848.8 | 94.3 | Cytoscape: a software environment for integrated models of biomolecular interaction networks. | Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker | Genome Res | 2003 | 14597658 | Yes |
| 414 | 4099 | 4099.0 | 145.4 | 145.4 | Health promotion by social cognitive means. | Albert Bandura | Health Educ Behav | 2004 | 15090118 | Yes |
| 415 | 8179 | 4089.5 | 291.4 | 145.7 | Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. | Laurent Excoffier, Heidi E L Lischer | Mol Ecol Resour | 2010 | 21565059 | Yes |
| 416 | 4072 | 4072.0 | 129.9 | 129.9 | What's wrong with Bonferroni adjustments. | T V Perneger | BMJ | 1998 | 9553006 | No |
| 417 | 8139 | 4069.5 | 156.4 | 78.2 | Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. | A H Brand, N Perrimon | Development | 1993 | 8223268 | Yes |
| 418 | 4064 | 4064.0 | 88.8 | 88.8 | Protein secondary structure prediction based on position-specific scoring matrices. | D T Jones | J Mol Biol | 1999 | 10493868 | Yes |
| 419 | 4064 | 4064.0 | 90.2 | 90.2 | Scaling and assessment of data quality. | Philip Evans | Acta Crystallogr D Biol Crystallogr | 2006 | 16369096 | No |
| 420 | 12185 | 4061.7 | 247.6 | 82.5 | Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. | J F Kerr, A H Wyllie, A R Currie | Br J Cancer | 1972 | 4561027 | No |
| 421 | 4054 | 4054.0 | 145.5 | 145.5 | Psychometric properties of the strengths and difficulties questionnaire. | R Goodman | J Am Acad Child Adolesc Psychiatry | 2001 | 11699809 | Yes |
| 422 | 4052 | 4052.0 | 91.4 | 91.4 | Instability and decay of the primary structure of DNA. | T Lindahl | Nature | 1993 | 8469282 | No |
| 423 | 8099 | 4049.5 | 155.6 | 77.8 | A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. | R S Sikorski, P Hieter | Genetics | 1989 | 2659436 | Yes |
| 424 | 4048 | 4048.0 | 112.8 | 112.8 | How do you feel? Interoception: the sense of the physiological condition of the body. | A D Craig | Nat Rev Neurosci | 2002 | 12154366 | No |
| 425 | 4026 | 4026.0 | 110.6 | 110.6 | What is the evidence that tumors are angiogenesis dependent? | J Folkman | J Natl Cancer Inst | 1990 | 1688381 | No |
| 426 | 4026 | 4026.0 | 107.3 | 107.3 | Integrins: a family of cell surface receptors. | R O Hynes | Cell | 1987 | 3028640 | No |
| 427 | 4022 | 4022.0 | 94.0 | 94.0 | Neural networks and physical systems with emergent collective computational abilities. | J J Hopfield | Proc Natl Acad Sci U S A | 1982 | 6953413 | Yes |
| 428 | 8043 | 4021.5 | 235.7 | 117.8 | BEAST: Bayesian evolutionary analysis by sampling trees. | Alexei J Drummond, Andrew Rambaut | BMC Evol Biol | 2007 | 17996036 | Yes |
| 429 | 4013 | 4013.0 | 102.0 | 102.0 | Sequencing technologies - the next generation. | Michael L Metzker | Nat Rev Genet | 2010 | 19997069 | No |
| 430 | 4000 | 4000.0 | 125.0 | 125.0 | Protective and damaging effects of stress mediators. | B S McEwen | N Engl J Med | 1998 | 9428819 | No |
| 431 | 3999 | 3999.0 | 134.7 | 134.7 | Tissue destruction by neutrophils. | S J Weiss | N Engl J Med | 1989 | 2536474 | No |
| 432 | 7992 | 3996.0 | 201.7 | 100.8 | Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. | Weizhong Li, Adam Godzik | Bioinformatics | 2006 | 16731699 | Yes |
| 433 | 3975 | 3975.0 | 0.0 | 0.0 | Staining of tissue sections for electron microscopy with heavy metals. | M L Watson | J Biophys Biochem Cytol | 1958 | 13563554 | Yes |
| 434 | 3975 | 3975.0 | 133.5 | 133.5 | genepop'007: a complete re-implementation of the genepop software for Windows and Linux. | Francois Rousset | Mol Ecol Resour | 2008 | 21585727 | Yes |
| 435 | 7948 | 3974.0 | 255.5 | 127.8 | Complex network measures of brain connectivity: uses and interpretations. | Mikail Rubinov, Olaf Sporns | Neuroimage | 2010 | 19819337 | Yes |
| 436 | 3974 | 3974.0 | 110.2 | 110.2 | The nuclear factor NF-kappaB pathway in inflammation. | Toby Lawrence | Cold Spring Harb Perspect Biol | 2009 | 20457564 | No |
| 437 | 3958 | 3958.0 | 111.8 | 111.8 | Graphene: status and prospects. | A K Geim | Science | 2009 | 19541989 | Yes |
| 438 | 3944 | 3944.0 | 0.0 | 0.0 | Generalized expectancies for internal versus external control of reinforcement. | J B Rotter | Psychol Monogr | 1966 | 5340840 | No |
| 439 | 3942 | 3942.0 | 134.8 | 134.8 | Basic principles of ROC analysis. | C E Metz | Semin Nucl Med | 1978 | 112681 | Yes |
| 440 | 3941 | 3941.0 | 115.6 | 115.6 | The adolescent brain and age-related behavioral manifestations. | L P Spear | Neurosci Biobehav Rev | 2000 | 10817843 | No |
| 441 | 7875 | 3937.5 | 300.2 | 150.1 | Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. | R M Ryan, E L Deci | Am Psychol | 2000 | 11392867 | Yes |
| 442 | 3935 | 3935.0 | 76.8 | 76.8 | Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. | G R Martin | Proc Natl Acad Sci U S A | 1981 | 6950406 | Yes |
| 443 | 3927 | 3927.0 | 129.2 | 129.2 | Nitric oxide as a secretory product of mammalian cells. | C Nathan | FASEB J | 1992 | 1381691 | No |
| 444 | 7852 | 3926.0 | 166.5 | 83.2 | Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. | H Aviv, P Leder | Proc Natl Acad Sci U S A | 1972 | 4504350 | Yes |
| 445 | 3926 | 3926.0 | 98.5 | 98.5 | I-TASSER server for protein 3D structure prediction. | Yang Zhang | BMC Bioinformatics | 2008 | 18215316 | Yes |
| 446 | 3920 | 3920.0 | 130.4 | 130.4 | No adjustments are needed for multiple comparisons. | K J Rothman | Epidemiology | 1990 | 2081237 | Yes |
| 447 | 3917 | 3917.0 | 0.0 | 0.0 | Disc Electrophoresis. I. Background And Theory. | L Ornstein | Ann N Y Acad Sci | 1964 | 14240533 | Yes |
| 448 | 7823 | 3911.5 | 319.2 | 159.6 | The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. | P F Lovibond, S H Lovibond | Behav Res Ther | 1995 | 7726811 | Yes |
| 449 | 3907 | 3907.0 | 89.6 | 89.6 | Novel proteinaceous infectious particles cause scrapie. | S B Prusiner | Science | 1982 | 6801762 | Yes |
| 450 | 11667 | 3889.0 | 295.3 | 98.4 | Canonical sampling through velocity rescaling. | Giovanni Bussi, Davide Donadio, Michele Parrinello | J Chem Phys | 2007 | 17212484 | Yes |
| 451 | 3889 | 3889.0 | 105.9 | 105.9 | Non-coding RNAs in human disease. | Manel Esteller | Nat Rev Genet | 2011 | 22094949 | No |
| 452 | 3885 | 3885.0 | 97.8 | 97.8 | Caspases: the executioners of apoptosis. | G M Cohen | Biochem J | 1997 | 9337844 | No |
| 453 | 3884 | 3884.0 | 103.0 | 103.0 | The pathobiology of diabetic complications: a unifying mechanism. | Michael Brownlee | Diabetes | 2005 | 15919781 | No |
| 454 | 3876 | 3876.0 | 104.3 | 104.3 | Preparation of isolated rat liver cells. | P O Seglen | Methods Cell Biol | 1976 | 177845 | No |
| 455 | 11563 | 3854.3 | 330.4 | 110.1 | GSVA: gene set variation analysis for microarray and RNA-seq data. | Sonja Hanzelmann, Robert Castelo, Justin Guinney | BMC Bioinformatics | 2013 | 23323831 | Yes |
| 456 | 7687 | 3843.5 | 297.3 | 148.7 | Microsomal lipid peroxidation. | J A Buege, S D Aust | Methods Enzymol | 1978 | 672633 | Yes |
| 457 | 3843 | 3843.0 | 111.6 | 111.6 | Revisions in the International System for Staging Lung Cancer. | C F Mountain | Chest | 1997 | 9187198 | Yes |
| 458 | 3841 | 3841.0 | 0.0 | 0.0 | Pharmacological implications of microsomal enzyme induction. | A H Conney | Pharmacol Rev | 1967 | 4383307 | Yes |
| 459 | 3838 | 3838.0 | 178.9 | 178.9 | The quality of care. How can it be assessed? | A Donabedian | JAMA | 1988 | 3045356 | No |
| 460 | 7637 | 3818.5 | 195.2 | 97.6 | Mitochondria and apoptosis. | D R Green, J C Reed | Science | 1998 | 9721092 | No |
| 461 | 7626 | 3813.0 | 640.5 | 320.2 | Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2021 | 33885785 | Yes |
| 462 | 3811 | 3811.0 | 81.6 | 81.6 | TGF-beta signal transduction. | J Massague | Annu Rev Biochem | 1998 | 9759503 | No |
| 463 | 3811 | 3811.0 | 93.6 | 93.6 | Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. | A T Brunger | Nature | 1992 | 18481394 | Yes |
| 464 | 3811 | 3811.0 | 136.9 | 136.9 | Role of nrf2 in oxidative stress and toxicity. | Qiang Ma | Annu Rev Pharmacol Toxicol | 2013 | 23294312 | No |
| 465 | 3803 | 3803.0 | 79.2 | 79.2 | A catalogue of splice junction sequences. | S M Mount | Nucleic Acids Res | 1982 | 7063411 | Yes |
| 466 | 7605 | 3802.5 | 174.7 | 87.3 | Functional rafts in cell membranes. | K Simons, E Ikonen | Nature | 1997 | 9177342 | No |
| 467 | 3801 | 3801.0 | 115.6 | 115.6 | Efficient methods to compute genomic predictions. | P M VanRaden | J Dairy Sci | 2008 | 18946147 | Yes |
| 468 | 11374 | 3791.3 | 281.4 | 93.8 | ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. | Kai Wang, Mingyao Li, Hakon Hakonarson | Nucleic Acids Res | 2010 | 20601685 | Yes |
| 469 | 3787 | 3787.0 | 129.5 | 129.5 | The Danish Civil Registration System. | Carsten Bocker Pedersen | Scand J Public Health | 2011 | 21775345 | Yes |
| 470 | 11346 | 3782.0 | 281.0 | 93.7 | Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nucleic Acids Res | 2009 | 19033363 | Yes |
| 471 | 3774 | 3774.0 | 149.1 | 149.1 | Microplastics in the marine environment. | Anthony L Andrady | Mar Pollut Bull | 2011 | 21742351 | No |
| 472 | 3762 | 3762.0 | 155.3 | 155.3 | Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. | Joseph P Weir | J Strength Cond Res | 2005 | 15705040 | No |
| 473 | 3759 | 3759.0 | 0.0 | 0.0 | Estimation of the molecular weights of proteins by Sephadex gel-filtration. | P Andrews | Biochem J | 1964 | 4158310 | Yes |
| 474 | 3758 | 3758.0 | 81.9 | 81.9 | Profile hidden Markov models. | S R Eddy | Bioinformatics | 1998 | 9918945 | No |
| 475 | 41324 | 3756.7 | 903.3 | 82.1 | Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. | Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov | Proc Natl Acad Sci U S A | 2005 | 16199517 | Yes |
| 476 | 3755 | 3755.0 | 108.7 | 108.7 | Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. | J H Morrissey | Anal Biochem | 1981 | 6172996 | Yes |
| 477 | 18744 | 3748.8 | 733.4 | 146.7 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | Ann Intern Med | 2009 | 19622511 | No |
| 478 | 3746 | 3746.0 | 158.5 | 158.5 | Statistics corner: A guide to appropriate use of correlation coefficient in medical research. | M M Mukaka | Malawi Med J | 2012 | 23638278 | Yes |
| 479 | 3737 | 3737.0 | 66.8 | 66.8 | Somatic generation of antibody diversity. | S Tonegawa | Nature | 1983 | 6300689 | No |
| 480 | 11191 | 3730.3 | 217.3 | 72.4 | Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. | J D Dignam, R M Lebovitz, R G Roeder | Nucleic Acids Res | 1983 | 6828386 | Yes |
| 481 | 3718 | 3718.0 | 108.0 | 108.0 | Biological roles of oligosaccharides: all of the theories are correct. | A Varki | Glycobiology | 1993 | 8490246 | No |
| 482 | 3711 | 3711.0 | 131.4 | 131.4 | Modeling valuations for EuroQol health states. | P Dolan | Med Care | 1997 | 9366889 | Yes |
| 483 | 3705 | 3705.0 | 0.0 | 0.0 | A membrane-filter technique for the detection of complementary DNA. | D T Denhardt | Biochem Biophys Res Commun | 1966 | 5963888 | Yes |
| 484 | 3705 | 3705.0 | 180.7 | 180.7 | Toward understanding the origin and evolution of cellular organisms. | Minoru Kanehisa | Protein Sci | 2019 | 31441146 | No |
| 485 | 7395 | 3697.5 | 176.2 | 88.1 | Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. | C Tuerk, L Gold | Science | 1990 | 2200121 | Yes |
| 486 | 3697 | 3697.0 | 91.3 | 91.3 | Glutamate uptake. | N C Danbolt | Prog Neurobiol | 2001 | 11369436 | No |
| 487 | 7388 | 3694.0 | 221.6 | 110.8 | Complex brain networks: graph theoretical analysis of structural and functional systems. | Ed Bullmore, Olaf Sporns | Nat Rev Neurosci | 2009 | 19190637 | No |
| 488 | 3673 | 3673.0 | 0.0 | 0.0 | The magical number seven plus or minus two: some limits on our capacity for processing information. | G A Miller | Psychol Rev | 1956 | 13310704 | Yes |
| 489 | 7333 | 3666.5 | 138.1 | 69.0 | Translating the histone code. | T Jenuwein, C D Allis | Science | 2001 | 11498575 | No |
| 490 | 3666 | 3666.0 | 129.9 | 129.9 | Estimation of average heterozygosity and genetic distance from a small number of individuals. | M Nei | Genetics | 1978 | 17248844 | Yes |
| 491 | 7324 | 3662.0 | 0.0 | 0.0 | Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. | D H Hubel, T N Wiesel | J Physiol | 1962 | 14449617 | Yes |
| 492 | 3650 | 3650.0 | 89.2 | 89.2 | Nonalcoholic fatty liver disease. | Paul Angulo | N Engl J Med | 2002 | 11961152 | No |
| 493 | 3649 | 3649.0 | 131.6 | 131.6 | Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. | O W Griffith | Anal Biochem | 1980 | 7416462 | Yes |
| 494 | 3648 | 3648.0 | 77.6 | 77.6 | Mammalian neural stem cells. | F H Gage | Science | 2000 | 10688783 | No |
| 495 | 7294 | 3647.0 | 220.8 | 110.4 | Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. | Jeng-Da Chai, Martin Head-Gordon | Phys Chem Chem Phys | 2008 | 18989472 | Yes |
| 496 | 3642 | 3642.0 | 90.5 | 90.5 | Marrow stromal cells as stem cells for nonhematopoietic tissues. | D J Prockop | Science | 1997 | 9082988 | No |
| 497 | 3640 | 3640.0 | 60.7 | 60.7 | Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. | J D Rowley | Nature | 1973 | 4126434 | Yes |
| 498 | 7269 | 3634.5 | 227.5 | 113.8 | The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. | Stephen B Edge, Carolyn C Compton | Ann Surg Oncol | 2010 | 20180029 | No |
| 499 | 3634 | 3634.0 | 72.8 | 72.8 | Signal transduction by the JNK group of MAP kinases. | R J Davis | Cell | 2000 | 11057897 | No |
| 500 | 7267 | 3633.5 | 148.2 | 74.1 | Statistical significance for genomewide studies. | John D Storey, Robert Tibshirani | Proc Natl Acad Sci U S A | 2003 | 12883005 | Yes |
| 501 | 3629 | 3629.0 | 114.1 | 114.1 | Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. | L R Squire | Psychol Rev | 1992 | 1594723 | No |
| 502 | 3628 | 3628.0 | 162.8 | 162.8 | Hepatocellular Carcinoma. | Augusto Villanueva | N Engl J Med | 2019 | 30970190 | No |
| 503 | 3625 | 3625.0 | 80.4 | 80.4 | Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. | H F Dvorak | N Engl J Med | 1986 | 3537791 | No |
| 504 | 3623 | 3623.0 | 98.9 | 98.9 | The basis of anisotropic water diffusion in the nervous system - a technical review. | Christian Beaulieu | NMR Biomed | 2002 | 12489094 | No |
| 505 | 18107 | 3621.4 | 687.0 | 137.4 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | BMJ | 2009 | 19622551 | No |
| 506 | 7242 | 3621.0 | 0.0 | 0.0 | The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. | R C Graham, M J Karnovsky | J Histochem Cytochem | 1966 | 5962951 | Yes |
| 507 | 3621 | 3621.0 | 136.5 | 136.5 | Essential oils: their antibacterial properties and potential applications in foods--a review. | Sara Burt | Int J Food Microbiol | 2004 | 15246235 | No |
| 508 | 3602 | 3602.0 | 97.6 | 97.6 | Microglia: a sensor for pathological events in the CNS. | G W Kreutzberg | Trends Neurosci | 1996 | 8843599 | No |
| 509 | 3600 | 3600.0 | 112.0 | 112.0 | Inositol trisphosphate and diacylglycerol as second messengers. | M J Berridge | Biochem J | 1984 | 6146314 | No |
| 510 | 3578 | 3578.0 | 92.0 | 92.0 | Cellular and molecular mechanisms of fibrosis. | T A Wynn | J Pathol | 2008 | 18161745 | No |
| 511 | 3576 | 3576.0 | 86.3 | 86.3 | Mitochondrial formation of reactive oxygen species. | Julio F Turrens | J Physiol | 2003 | 14561818 | No |
| 512 | 3575 | 3575.0 | 90.2 | 90.2 | The heat-shock response. | S Lindquist | Annu Rev Biochem | 1986 | 2427013 | No |
| 513 | 3572 | 3572.0 | 132.4 | 132.4 | Social cognitive theory: an agentic perspective. | A Bandura | Annu Rev Psychol | 2001 | 11148297 | Yes |
| 514 | 7139 | 3569.5 | 207.6 | 103.8 | Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. | C Beauchamp, I Fridovich | Anal Biochem | 1971 | 4943714 | Yes |
| 515 | 7130 | 3565.0 | 140.1 | 70.0 | The ubiquitin system. | A Hershko, A Ciechanover | Annu Rev Biochem | 1998 | 9759494 | No |
| 516 | 7109 | 3554.5 | 176.9 | 88.5 | Exploring the full spectrum of macrophage activation. | David M Mosser, Justin P Edwards | Nat Rev Immunol | 2008 | 19029990 | No |
| 517 | 3550 | 3550.0 | 193.7 | 193.7 | Obesity: global epidemiology and pathogenesis. | Matthias Bluher | Nat Rev Endocrinol | 2019 | 30814686 | No |
| 518 | 7083 | 3541.5 | 144.5 | 72.2 | A new method for sequencing DNA. | A M Maxam, W Gilbert | Proc Natl Acad Sci U S A | 1977 | 265521 | Yes |
| 519 | 28331 | 3541.4 | 663.7 | 83.0 | The Protein Data Bank. | H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne | Nucleic Acids Res | 2000 | 10592235 | Yes |
| 520 | 3535 | 3535.0 | 97.1 | 97.1 | Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. | R W Mahley | Science | 1988 | 3283935 | No |
| 521 | 3529 | 3529.0 | 76.5 | 76.5 | Alzheimer's disease is a synaptic failure. | Dennis J Selkoe | Science | 2002 | 12399581 | No |
| 522 | 7058 | 3529.0 | 188.9 | 94.5 | The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. | Taro Kawai, Shizuo Akira | Nat Immunol | 2010 | 20404851 | No |
| 523 | 3528 | 3528.0 | 0.0 | 0.0 | Spectroscopic determination of tryptophan and tyrosine in proteins. | H Edelhoch | Biochemistry | 1967 | 6049437 | Yes |
| 524 | 21159 | 3526.5 | 1055.5 | 175.9 | DADA2: High-resolution sample inference from Illumina amplicon data. | Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P Holmes | Nat Methods | 2016 | 27214047 | Yes |
| 525 | 7048 | 3524.0 | 206.3 | 103.2 | Projections of global mortality and burden of disease from 2002 to 2030. | Colin D Mathers, Dejan Loncar | PLoS Med | 2006 | 17132052 | Yes |
| 526 | 3523 | 3523.0 | 78.6 | 78.6 | Cardiac excitation-contraction coupling. | Donald M Bers | Nature | 2002 | 11805843 | No |
| 527 | 3522 | 3522.0 | 0.0 | 0.0 | The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. | J F Woessner | Arch Biochem Biophys | 1961 | 13786180 | Yes |
| 528 | 17601 | 3520.2 | 500.0 | 100.0 | Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. | O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth | Pflugers Arch | 1981 | 6270629 | Yes |
| 529 | 3519 | 3519.0 | 93.0 | 93.0 | Biologic basis for interleukin-1 in disease. | C A Dinarello | Blood | 1996 | 8630372 | No |
| 530 | 3517 | 3517.0 | 112.1 | 112.1 | The free-energy principle: a unified brain theory? | Karl Friston | Nat Rev Neurosci | 2010 | 20068583 | No |
| 531 | 7011 | 3505.5 | 235.9 | 118.0 | Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. | K Tamura, M Nei | Mol Biol Evol | 1993 | 8336541 | Yes |
| 532 | 10503 | 3501.0 | 315.8 | 105.3 | FastTree 2--approximately maximum-likelihood trees for large alignments. | Morgan N Price, Paramvir S Dehal, Adam P Arkin | PLoS One | 2010 | 20224823 | Yes |
| 533 | 3499 | 3499.0 | 70.1 | 70.1 | The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. | Isaiah J Fidler | Nat Rev Cancer | 2003 | 12778135 | No |
| 534 | 3497 | 3497.0 | 108.4 | 108.4 | Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. | Thomas Welton | Chem Rev | 1999 | 11849019 | Yes |
| 535 | 3494 | 3494.0 | 89.4 | 89.4 | Wound healing--aiming for perfect skin regeneration. | P Martin | Science | 1997 | 9082989 | No |
| 536 | 6988 | 3494.0 | 158.5 | 79.2 | Angiogenesis in cancer and other diseases. | P Carmeliet, R K Jain | Nature | 2000 | 11001068 | No |
| 537 | 6977 | 3488.5 | 199.5 | 99.8 | Velvet: algorithms for de novo short read assembly using de Bruijn graphs. | Daniel R Zerbino, Ewan Birney | Genome Res | 2008 | 18349386 | Yes |
| 538 | 3487 | 3487.0 | 120.7 | 120.7 | What is value in health care? | Michael E Porter | N Engl J Med | 2010 | 21142528 | Yes |
| 539 | 3484 | 3484.0 | 0.0 | 0.0 | Statistical estimations in enzyme kinetics. | G N Wilkinson | Biochem J | 1961 | 13785321 | Yes |
| 540 | 3476 | 3476.0 | 185.4 | 185.4 | Conservation of resources. A new attempt at conceptualizing stress. | S E Hobfoll | Am Psychol | 1989 | 2648906 | No |
| 541 | 6941 | 3470.5 | 158.3 | 79.2 | Electrochemical photolysis of water at a semiconductor electrode. | A Fujishima, K Honda | Nature | 1972 | 12635268 | Yes |
| 542 | 3466 | 3466.0 | 96.2 | 96.2 | Hay fever, hygiene, and household size. | D P Strachan | BMJ | 1989 | 2513902 | Yes |
| 543 | 6919 | 3459.5 | 266.0 | 133.0 | Measuring agreement in method comparison studies. | J M Bland, D G Altman | Stat Methods Med Res | 1999 | 10501650 | No |
| 544 | 6911 | 3455.5 | 199.7 | 99.8 | mTOR signaling in growth control and disease. | Mathieu Laplante, David M Sabatini | Cell | 2012 | 22500797 | No |
| 545 | 3455 | 3455.0 | 75.0 | 75.0 | Protein folding and misfolding. | Christopher M Dobson | Nature | 2003 | 14685248 | No |
| 546 | 10353 | 3451.0 | 541.3 | 180.4 | Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. | P J Van Soest, J B Robertson, B A Lewis | J Dairy Sci | 1991 | 1660498 | No |
| 547 | 10343 | 3447.7 | 321.5 | 107.2 | Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. | G Evanno, S Regnaut, J Goudet | Mol Ecol | 2005 | 15969739 | Yes |
| 548 | 6879 | 3439.5 | 169.7 | 84.8 | "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. | A P Feinberg, B Vogelstein | Anal Biochem | 1984 | 6329026 | Yes |
| 549 | 6873 | 3436.5 | 297.6 | 148.8 | GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. | Rod Peakall, Peter E Smouse | Bioinformatics | 2012 | 22820204 | Yes |
| 550 | 3435 | 3435.0 | 0.0 | 0.0 | Some factors in the interpretation of protein denaturation. | W Kauzmann | Adv Protein Chem | 1959 | 14404936 | Yes |
| 551 | 6868 | 3434.0 | 167.7 | 83.8 | In vitro selection of RNA molecules that bind specific ligands. | A D Ellington, J W Szostak | Nature | 1990 | 1697402 | Yes |
| 552 | 3432 | 3432.0 | 0.0 | 0.0 | A Rationale And Test For The Number Of Factors In Factor Analysis. | J L Horn | Psychometrika | 1965 | 14306381 | Yes |
| 553 | 3430 | 3430.0 | 84.8 | 84.8 | Modularity and community structure in networks. | M E J Newman | Proc Natl Acad Sci U S A | 2006 | 16723398 | Yes |
| 554 | 6823 | 3411.5 | 0.0 | 0.0 | The serial cultivation of human diploid cell strains. | L Hayflick, P S Moorhead | Exp Cell Res | 1961 | 13905658 | Yes |
| 555 | 6822 | 3411.0 | 177.2 | 88.6 | Human malaria parasites in continuous culture. | W Trager, J B Jensen | Science | 1976 | 781840 | Yes |
| 556 | 3403 | 3403.0 | 111.1 | 111.1 | Transformed up-down methods in psychoacoustics. | H Levitt | J Acoust Soc Am | 1971 | 5541744 | Yes |
| 557 | 3400 | 3400.0 | 78.8 | 78.8 | Tolerance, danger, and the extended family. | P Matzinger | Annu Rev Immunol | 1994 | 8011301 | No |
| 558 | 3400 | 3400.0 | 119.1 | 119.1 | Development of a classification system for periodontal diseases and conditions. | G C Armitage | Ann Periodontol | 1999 | 10863370 | No |
| 559 | 3399 | 3399.0 | 85.5 | 85.5 | Photoelectrochemical cells. | M Gratzel | Nature | 2001 | 11713540 | Yes |
| 560 | 6797 | 3398.5 | 176.1 | 88.0 | TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. | T R Mosmann, R L Coffman | Annu Rev Immunol | 1989 | 2523712 | No |
| 561 | 10173 | 3391.0 | 443.5 | 147.8 | Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. | J L Cox, J M Holden, R Sagovsky | Br J Psychiatry | 1987 | 3651732 | Yes |
| 562 | 3384 | 3384.0 | 80.8 | 80.8 | The dendritic cell system and its role in immunogenicity. | R M Steinman | Annu Rev Immunol | 1991 | 1910679 | No |
| 563 | 10152 | 3384.0 | 0.0 | 0.0 | The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. | F C Greenwood, W M Hunter, J S Glover | Biochem J | 1963 | 14097352 | Yes |
| 564 | 6765 | 3382.5 | 0.0 | 0.0 | Pain mechanisms: a new theory. | R Melzack, P D Wall | Science | 1965 | 5320816 | No |
| 565 | 3379 | 3379.0 | 118.3 | 118.3 | The biology and function of fibroblasts in cancer. | Raghu Kalluri | Nat Rev Cancer | 2016 | 27550820 | No |
| 566 | 3376 | 3376.0 | 78.3 | 78.3 | Calcium signaling. | David E Clapham | Cell | 2007 | 18083096 | No |
| 567 | 10126 | 3375.3 | 199.1 | 66.4 | Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. | Ron Edgar, Michael Domrachev, Alex E Lash | Nucleic Acids Res | 2002 | 11752295 | Yes |
| 568 | 3374 | 3374.0 | 107.5 | 107.5 | Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. | Y X Fu | Genetics | 1997 | 9335623 | Yes |
| 569 | 3374 | 3374.0 | 65.0 | 65.0 | Cell signaling by receptor tyrosine kinases. | J Schlessinger | Cell | 2000 | 11057895 | No |
| 570 | 6742 | 3371.0 | 177.5 | 88.8 | Pattern recognition receptors and inflammation. | Osamu Takeuchi, Shizuo Akira | Cell | 2010 | 20303872 | No |
| 571 | 3369 | 3369.0 | 70.1 | 70.1 | The scanning model for translation: an update. | M Kozak | J Cell Biol | 1989 | 2645293 | No |
| 572 | 3368 | 3368.0 | 87.0 | 87.0 | Recent advances with liposomes as pharmaceutical carriers. | Vladimir P Torchilin | Nat Rev Drug Discov | 2005 | 15688077 | No |
| 573 | 3363 | 3363.0 | 126.3 | 126.3 | The processing-speed theory of adult age differences in cognition. | T A Salthouse | Psychol Rev | 1996 | 8759042 | No |
| 574 | 3363 | 3363.0 | 97.8 | 97.8 | Parkinson's disease: clinical features and diagnosis. | J Jankovic | J Neurol Neurosurg Psychiatry | 2008 | 18344392 | No |
| 575 | 3361 | 3361.0 | 82.2 | 82.2 | The resurgence of platinum-based cancer chemotherapy. | Lloyd Kelland | Nat Rev Cancer | 2007 | 17625587 | No |
| 576 | 3341 | 3341.0 | 93.0 | 93.0 | ABC transporters: from microorganisms to man. | C F Higgins | Annu Rev Cell Biol | 1992 | 1282354 | No |
| 577 | 3340 | 3340.0 | 139.5 | 139.5 | Half a century of research on the Stroop effect: an integrative review. | C M MacLeod | Psychol Bull | 1991 | 2034749 | No |
| 578 | 6678 | 3339.0 | 321.1 | 160.6 | Stress, social support, and the buffering hypothesis. | S Cohen, T A Wills | Psychol Bull | 1985 | 3901065 | No |
| 579 | 3339 | 3339.0 | 71.1 | 71.1 | Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. | M Kozak | Nucleic Acids Res | 1984 | 6694911 | Yes |
| 580 | 3337 | 3337.0 | 72.7 | 72.7 | TGFbeta in Cancer. | Joan Massague | Cell | 2008 | 18662538 | No |
| 581 | 3333 | 3333.0 | 77.6 | 77.6 | T cell exhaustion. | E John Wherry | Nat Immunol | 2011 | 21739672 | No |
| 582 | 6665 | 3332.5 | 188.3 | 94.2 | Voxel-based morphometry--the methods. | J Ashburner, K J Friston | Neuroimage | 2000 | 10860804 | No |
| 583 | 13312 | 3328.0 | 512.8 | 128.2 | APACHE II: a severity of disease classification system. | W A Knaus, E A Draper, D P Wagner, J E Zimmerman | Crit Care Med | 1985 | 3928249 | Yes |
| 584 | 3325 | 3325.0 | 142.4 | 142.4 | Measures of reliability in sports medicine and science. | W G Hopkins | Sports Med | 2000 | 10907753 | Yes |
| 585 | 3324 | 3324.0 | 157.2 | 157.2 | Measurement of pain. | E C Huskisson | Lancet | 1974 | 4139420 | Yes |
| 586 | 3324 | 3324.0 | 94.4 | 94.4 | The unfolded protein response: controlling cell fate decisions under ER stress and beyond. | Claudio Hetz | Nat Rev Mol Cell Biol | 2012 | 22251901 | No |
| 587 | 3303 | 3303.0 | 86.5 | 86.5 | Gene regulation by steroid hormones. | M Beato | Cell | 1989 | 2644044 | No |
| 588 | 3299 | 3299.0 | 0.0 | 0.0 | Equilibrium Ultracentrifugation Of Dilute Solutions. | D A Yphantis | Biochemistry | 1964 | 14155091 | Yes |
| 589 | 3298 | 3298.0 | 85.3 | 85.3 | Lead- and drug-like compounds: the rule-of-five revolution. | Christopher A Lipinski | Drug Discov Today Technol | 2004 | 24981612 | Yes |
| 590 | 3297 | 3297.0 | 97.2 | 97.2 | A rating instrument for anxiety disorders. | W W Zung | Psychosomatics | 1971 | 5172928 | Yes |
| 591 | 13149 | 3287.2 | 407.9 | 102.0 | Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. | Qiong Wang, George M Garrity, James M Tiedje, James R Cole | Appl Environ Microbiol | 2007 | 17586664 | Yes |
| 592 | 3283 | 3283.0 | 64.2 | 64.2 | Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. | P Schuck | Biophys J | 2000 | 10692345 | Yes |
| 593 | 3281 | 3281.0 | 75.2 | 75.2 | Activators and target genes of Rel/NF-kappaB transcription factors. | H L Pahl | Oncogene | 1999 | 10602461 | No |
| 594 | 3276 | 3276.0 | 71.7 | 71.7 | Angiogenesis in health and disease. | Peter Carmeliet | Nat Med | 2003 | 12778163 | No |
| 595 | 3267 | 3267.0 | 67.0 | 67.0 | STATs and gene regulation. | J E Darnell | Science | 1997 | 9287210 | No |
| 596 | 3265 | 3265.0 | 69.1 | 69.1 | CpG-rich islands and the function of DNA methylation. | A P Bird | Nature | 1986 | 2423876 | No |
| 597 | 6527 | 3263.5 | 186.0 | 93.0 | Unified segmentation. | John Ashburner, Karl J Friston | Neuroimage | 2005 | 15955494 | Yes |
| 598 | 3262 | 3262.0 | 150.3 | 150.3 | The short-form McGill Pain Questionnaire. | Ronald Melzack | Pain | 1987 | 3670870 | Yes |
| 599 | 3255 | 3255.0 | 144.7 | 144.7 | Abiotic Stress Signaling and Responses in Plants. | Jian-Kang Zhu | Cell | 2016 | 27716505 | No |
| 600 | 3252 | 3252.0 | 117.9 | 117.9 | The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. | B L Fredrickson | Am Psychol | 2001 | 11315248 | Yes |
| 601 | 9755 | 3251.7 | 259.8 | 86.6 | Regularization Paths for Generalized Linear Models via Coordinate Descent. | Jerome Friedman, Trevor Hastie, Rob Tibshirani | J Stat Softw | 2010 | 20808728 | Yes |
| 602 | 3250 | 3250.0 | 0.0 | 0.0 | Gene action in the X-chromosome of the mouse (Mus musculus L.). | M F Lyon | Nature | 1961 | 13764598 | Yes |
| 603 | 6494 | 3247.0 | 118.4 | 59.2 | The language of covalent histone modifications. | B D Strahl, C D Allis | Nature | 2000 | 10638745 | Yes |
| 604 | 3245 | 3245.0 | 96.7 | 96.7 | Inositol trisphosphate and diacylglycerol: two interacting second messengers. | M J Berridge | Annu Rev Biochem | 1987 | 3304132 | No |
| 605 | 12979 | 3244.8 | 309.8 | 77.5 | Improved methods for building protein models in electron density maps and the location of errors in these models. | T A Jones, J Y Zou, S W Cowan, M Kjeldgaard | Acta Crystallogr A | 1991 | 2025413 | Yes |
| 606 | 6484 | 3242.0 | 158.6 | 79.3 | Oxidants, oxidative stress and the biology of ageing. | T Finkel, N J Holbrook | Nature | 2000 | 11089981 | No |
| 607 | 3240 | 3240.0 | 126.3 | 126.3 | Central sensitization: implications for the diagnosis and treatment of pain. | Clifford J Woolf | Pain | 2011 | 20961685 | No |
| 608 | 3239 | 3239.0 | 84.6 | 84.6 | MapChart: software for the graphical presentation of linkage maps and QTLs. | R E Voorrips | J Hered | 2002 | 12011185 | Yes |
| 609 | 3234 | 3234.0 | 73.3 | 73.3 | Mechanisms of angiogenesis and arteriogenesis. | P Carmeliet | Nat Med | 2000 | 10742145 | No |
| 610 | 6466 | 3233.0 | 143.3 | 71.7 | Toll-like receptor signalling. | Shizuo Akira, Kiyoshi Takeda | Nat Rev Immunol | 2004 | 15229469 | No |
| 611 | 3230 | 3230.0 | 83.4 | 83.4 | Obesity as a medical problem. | P G Kopelman | Nature | 2000 | 10766250 | No |
| 612 | 6455 | 3227.5 | 144.5 | 72.2 | Emergence of scaling in random networks | A L Barabasi, R Albert | Science | 1999 | 10521342 | Yes |
| 613 | 3221 | 3221.0 | 91.5 | 91.5 | Hepatocellular carcinoma. | Hashem B El-Serag | N Engl J Med | 2011 | 21992124 | No |
| 614 | 3216 | 3216.0 | 74.6 | 74.6 | Autophagy: process and function. | Noboru Mizushima | Genes Dev | 2007 | 18006683 | No |
| 615 | 3207 | 3207.0 | 142.5 | 142.5 | Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. | T E Moffitt | Psychol Rev | 1993 | 8255953 | No |
| 616 | 9621 | 3207.0 | 208.6 | 69.5 | Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. | Benjamin P Lewis, Christopher B Burge, David P Bartel | Cell | 2005 | 15652477 | Yes |
| 617 | 6391 | 3195.5 | 147.5 | 73.8 | MicroRNA signatures in human cancers. | George A Calin, Carlo M Croce | Nat Rev Cancer | 2006 | 17060945 | No |
| 618 | 6382 | 3191.0 | 0.0 | 0.0 | A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. | S Reitman, S Frankel | Am J Clin Pathol | 1957 | 13458125 | Yes |
| 619 | 6371 | 3185.5 | 156.7 | 78.3 | Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. | T C Chou, P Talalay | Adv Enzyme Regul | 1984 | 6382953 | Yes |
| 620 | 6359 | 3179.5 | 209.0 | 104.5 | Extracellular vesicles: exosomes, microvesicles, and friends. | Graca Raposo, Willem Stoorvogel | J Cell Biol | 2013 | 23420871 | No |
| 621 | 3178 | 3178.0 | 76.4 | 76.4 | WHAT IF: a molecular modeling and drug design program. | G Vriend | J Mol Graph | 1990 | 2268628 | Yes |
| 622 | 3177 | 3177.0 | 76.1 | 76.1 | Optimal two-stage designs for phase II clinical trials. | R Simon | Control Clin Trials | 1989 | 2702835 | Yes |
| 623 | 3174 | 3174.0 | 101.4 | 101.4 | Estimation of metabolite concentrations from localized in vivo proton NMR spectra. | S W Provencher | Magn Reson Med | 1993 | 8139448 | Yes |
| 624 | 3168 | 3168.0 | 80.1 | 80.1 | The transforming growth factor-beta family. | J Massague | Annu Rev Cell Biol | 1990 | 2177343 | No |
| 625 | 3143 | 3143.0 | 0.0 | 0.0 | Diffusion-in-gel methods for immunological analysis. | O Ouchterlony | Prog Allergy | 1958 | 13578996 | Yes |
| 626 | 9424 | 3141.3 | 224.9 | 75.0 | The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. | R C Lee, R L Feinbaum, V Ambros | Cell | 1993 | 8252621 | Yes |
| 627 | 3141 | 3141.0 | 146.3 | 146.3 | The antibiotic resistance crisis: part 1: causes and threats. | C Lee Ventola | P T | 2015 | 25859123 | Yes |
| 628 | 3140 | 3140.0 | 101.8 | 101.8 | Doxil®--the first FDA-approved nano-drug: lessons learned. | Yechezkel Barenholz | J Control Release | 2012 | 22484195 | No |
| 629 | 9406 | 3135.3 | 322.3 | 107.4 | Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. | R A Deyo, D C Cherkin, M A Ciol | J Clin Epidemiol | 1992 | 1607900 | Yes |
| 630 | 6265 | 3132.5 | 216.1 | 108.0 | Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. | S Marklund, G Marklund | Eur J Biochem | 1974 | 4215654 | Yes |
| 631 | 6263 | 3131.5 | 138.8 | 69.4 | Inflammation and cancer: back to Virchow? | F Balkwill, A Mantovani | Lancet | 2001 | 11229684 | No |
| 632 | 9373 | 3124.3 | 323.6 | 107.9 | Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. | R M Palmer, A G Ferrige, S Moncada | Nature | 1987 | 3495737 | Yes |
| 633 | 6248 | 3124.0 | 194.3 | 97.2 | Nonparametric statistical testing of EEG- and MEG-data. | Eric Maris, Robert Oostenveld | J Neurosci Methods | 2007 | 17517438 | Yes |
| 634 | 3123 | 3123.0 | 96.3 | 96.3 | Stress, adaptation, and disease. Allostasis and allostatic load. | B S McEwen | Ann N Y Acad Sci | 1998 | 9629234 | No |
| 635 | 12467 | 3116.8 | 312.5 | 78.1 | Haploview: analysis and visualization of LD and haplotype maps. | J C Barrett, B Fry, J Maller, M J Daly | Bioinformatics | 2005 | 15297300 | Yes |
| 636 | 3112 | 3112.0 | 86.2 | 86.2 | Dietary pattern analysis: a new direction in nutritional epidemiology. | Frank B Hu | Curr Opin Lipidol | 2002 | 11790957 | No |
| 637 | 9336 | 3112.0 | 219.6 | 73.2 | TopHat: discovering splice junctions with RNA-Seq. | Cole Trapnell, Lior Pachter, Steven L Salzberg | Bioinformatics | 2009 | 19289445 | Yes |
| 638 | 3110 | 3110.0 | 108.7 | 108.7 | SF-36 health survey update. | J E Ware | Spine (Phila Pa 1976) | 2000 | 11124729 | No |
| 639 | 6195 | 3097.5 | 188.0 | 94.0 | Microenvironmental regulation of tumor progression and metastasis. | Daniela F Quail, Johanna A Joyce | Nat Med | 2013 | 24202395 | No |
| 640 | 3097 | 3097.0 | 100.1 | 100.1 | Colorimetric assay of catalase. | A K Sinha | Anal Biochem | 1972 | 4556490 | Yes |
| 641 | 3091 | 3091.0 | 0.0 | 0.0 | Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. | P Mitchell | Nature | 1961 | 13771349 | Yes |
| 642 | 3088 | 3088.0 | 133.4 | 133.4 | What's in a name? Qualitative description revisited. | Margarete Sandelowski | Res Nurs Health | 2010 | 20014004 | Yes |
| 643 | 3088 | 3088.0 | 106.8 | 106.8 | Large-scale brain networks and psychopathology: a unifying triple network model. | Vinod Menon | Trends Cogn Sci | 2011 | 21908230 | No |
| 644 | 9256 | 3085.3 | 478.6 | 159.5 | SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. | Antoine Daina, Olivier Michielin, Vincent Zoete | Sci Rep | 2017 | 28256516 | Yes |
| 645 | 3084 | 3084.0 | 63.5 | 63.5 | Elastic properties of lipid bilayers: theory and possible experiments. | W Helfrich | Z Naturforsch C | 1973 | 4273690 | Yes |
| 646 | 3080 | 3080.0 | 0.0 | 0.0 | The genetical structure of populations. | S Wright | Ann Eugen | 1951 | 24540312 | Yes |
| 647 | 3077 | 3077.0 | 74.8 | 74.8 | Salt and drought stress signal transduction in plants. | Jian-Kang Zhu | Annu Rev Plant Biol | 2002 | 12221975 | No |
| 648 | 9214 | 3071.3 | 386.6 | 128.9 | Fast and sensitive protein alignment using DIAMOND. | Benjamin Buchfink, Chao Xie, Daniel H Huson | Nat Methods | 2015 | 25402007 | Yes |
| 649 | 3070 | 3070.0 | 0.0 | 0.0 | A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. | S Hakomori | J Biochem | 1964 | 14135466 | Yes |
| 650 | 3068 | 3068.0 | 72.9 | 72.9 | Cadherin cell adhesion receptors as a morphogenetic regulator. | M Takeichi | Science | 1991 | 2006419 | No |
| 651 | 6135 | 3067.5 | 202.1 | 101.0 | Tissue engineering. | R Langer, J P Vacanti | Science | 1993 | 8493529 | No |
| 652 | 3067 | 3067.0 | 82.5 | 82.5 | Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. | S W Kessler | J Immunol | 1975 | 1102604 | Yes |
| 653 | 3058 | 3058.0 | 103.6 | 103.6 | An empirical correction for absorption anisotropy. | R H Blessing | Acta Crystallogr A | 1995 | 7702794 | Yes |
| 654 | 6113 | 3056.5 | 240.0 | 120.0 | Assessment of outcome after severe brain damage. | B Jennett, M Bond | Lancet | 1975 | 46957 | Yes |
| 655 | 3056 | 3056.0 | 58.6 | 58.6 | RNA interference. | Gregory J Hannon | Nature | 2002 | 12110901 | No |
| 656 | 6107 | 3053.5 | 240.3 | 120.2 | The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. | S H Downs, N Black | J Epidemiol Community Health | 1998 | 9764259 | Yes |
| 657 | 3047 | 3047.0 | 0.0 | 0.0 | Catheter replacement of the needle in percutaneous arteriography; a new technique. | S I Seldinger | Acta Radiol (Stockh) | 1953 | 13057644 | Yes |
| 658 | 3042 | 3042.0 | 63.9 | 63.9 | Toll-like receptors and innate immunity. | R Medzhitov | Nat Rev Immunol | 2001 | 11905821 | No |
| 659 | 3042 | 3042.0 | 89.0 | 89.0 | Physiology and neurobiology of stress and adaptation: central role of the brain. | Bruce S McEwen | Physiol Rev | 2007 | 17615391 | No |
| 660 | 9112 | 3037.3 | 189.3 | 63.1 | Significance analysis of microarrays applied to the ionizing radiation response. | V G Tusher, R Tibshirani, G Chu | Proc Natl Acad Sci U S A | 2001 | 11309499 | Yes |
| 661 | 3033 | 3033.0 | 62.5 | 62.5 | Papillomaviruses and cancer: from basic studies to clinical application. | Harald Zur Hausen | Nat Rev Cancer | 2002 | 12044010 | No |
| 662 | 6061 | 3030.5 | 200.4 | 100.2 | Computed tomography--an increasing source of radiation exposure. | David J Brenner, Eric J Hall | N Engl J Med | 2007 | 18046031 | No |
| 663 | 3025 | 3025.0 | 73.7 | 73.7 | Structure and function of telomeres. | E H Blackburn | Nature | 1991 | 1708110 | No |
| 664 | 3022 | 3022.0 | 85.1 | 85.1 | The genetic legacy of the Quaternary ice ages. | G Hewitt | Nature | 2000 | 10879524 | No |
| 665 | 3018 | 3018.0 | 89.6 | 89.6 | The magical number 4 in short-term memory: a reconsideration of mental storage capacity. | N Cowan | Behav Brain Sci | 2001 | 11515286 | Yes |
| 666 | 3015 | 3015.0 | 78.9 | 78.9 | Molecular basis of bacterial outer membrane permeability revisited. | Hiroshi Nikaido | Microbiol Mol Biol Rev | 2003 | 14665678 | No |
| 667 | 3015 | 3015.0 | 96.8 | 96.8 | Receiver operating characteristic curve in diagnostic test assessment. | Jayawant N Mandrekar | J Thorac Oncol | 2010 | 20736804 | No |
| 668 | 3014 | 3014.0 | 0.0 | 0.0 | A study of fixation for electron microscopy. | G E Palade | J Exp Med | 1952 | 14927794 | Yes |
| 669 | 6027 | 3013.5 | 0.0 | 0.0 | Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. | J Sedlak, R H Lindsay | Anal Biochem | 1968 | 4973948 | Yes |
| 670 | 3007 | 3007.0 | 82.6 | 82.6 | Analysis of gene diversity in subdivided populations. | M Nei | Proc Natl Acad Sci U S A | 1973 | 4519626 | Yes |
| 671 | 3003 | 3003.0 | 67.2 | 67.2 | Nuclear factor-kappaB in cancer development and progression. | Michael Karin | Nature | 2006 | 16724054 | No |
| 672 | 6004 | 3002.0 | 161.6 | 80.8 | Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. | G Kresse, J Hafner | Phys Rev B Condens Matter | 1994 | 10010505 | Yes |
| 673 | 9005 | 3001.7 | 214.3 | 71.4 | Pathogen recognition and innate immunity. | Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi | Cell | 2006 | 16497588 | No |
| 674 | 2997 | 2997.0 | 78.8 | 78.8 | Network pharmacology: the next paradigm in drug discovery. | Andrew L Hopkins | Nat Chem Biol | 2008 | 18936753 | No |
| 675 | 17948 | 2991.3 | 411.3 | 68.5 | Phaser crystallographic software. | Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read | J Appl Crystallogr | 2007 | 19461840 | Yes |
| 676 | 5982 | 2991.0 | 137.5 | 68.8 | The fluid mosaic model of the structure of cell membranes. | S J Singer, G L Nicolson | Science | 1972 | 4333397 | Yes |
| 677 | 5969 | 2984.5 | 127.0 | 63.5 | Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. | D B Smith, K S Johnson | Gene | 1988 | 3047011 | Yes |
| 678 | 2984 | 2984.0 | 96.8 | 96.8 | Matrix metalloproteinases and their inhibitors in connective tissue remodeling. | J F Woessner | FASEB J | 1991 | 1850705 | No |
| 679 | 2975 | 2975.0 | 0.0 | 0.0 | The gel-filtration behaviour of proteins related to their molecular weights over a wide range. | P Andrews | Biochem J | 1965 | 5862401 | Yes |
| 680 | 2972 | 2972.0 | 64.8 | 64.8 | Towards a network theory of the immune system. | N K Jerne | Ann Immunol (Paris) | 1974 | 4142565 | No |
| 681 | 2970 | 2970.0 | 45.1 | 45.1 | A gene complex controlling segmentation in Drosophila. | E B Lewis | Nature | 1978 | 103000 | Yes |
| 682 | 2970 | 2970.0 | 57.7 | 57.7 | Models for the specific adhesion of cells to cells. | G I Bell | Science | 1978 | 347575 | No |
| 683 | 2969 | 2969.0 | 90.7 | 90.7 | Gctf: Real-time CTF determination and correction. | Kai Zhang | J Struct Biol | 2016 | 26592709 | Yes |
| 684 | 5937 | 2968.5 | 142.3 | 71.2 | Autophagy in the pathogenesis of disease. | Beth Levine, Guido Kroemer | Cell | 2008 | 18191218 | No |
| 685 | 2963 | 2963.0 | 114.1 | 114.1 | Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. | Konrad M Andrassy | Kidney Int | 2013 | 23989362 | Yes |
| 686 | 2961 | 2961.0 | 119.6 | 119.6 | Metazoan MicroRNAs. | David P Bartel | Cell | 2018 | 29570994 | No |
| 687 | 8876 | 2958.7 | 255.7 | 85.2 | Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. | Y Gavrieli, Y Sherman, S A Ben-Sasson | J Cell Biol | 1992 | 1400587 | Yes |
| 688 | 2957 | 2957.0 | 59.3 | 59.3 | Interleukin-12 and the regulation of innate resistance and adaptive immunity. | Giorgio Trinchieri | Nat Rev Immunol | 2003 | 12563297 | No |
| 689 | 5914 | 2957.0 | 136.5 | 68.2 | Oncomirs - microRNAs with a role in cancer. | Aurora Esquela-Kerscher, Frank J Slack | Nat Rev Cancer | 2006 | 16557279 | No |
| 690 | 2955 | 2955.0 | 56.4 | 56.4 | Genome maintenance mechanisms for preventing cancer. | J H Hoeijmakers | Nature | 2001 | 11357144 | No |
| 691 | 2954 | 2954.0 | 91.5 | 91.5 | Primate models of movement disorders of basal ganglia origin. | M R DeLong | Trends Neurosci | 1990 | 1695404 | No |
| 692 | 2948 | 2948.0 | 90.8 | 90.8 | Implications of normal brain development for the pathogenesis of schizophrenia. | D R Weinberger | Arch Gen Psychiatry | 1987 | 3606332 | Yes |
| 693 | 2948 | 2948.0 | 52.0 | 52.0 | Mechanisms underlying ubiquitination. | C M Pickart | Annu Rev Biochem | 2001 | 11395416 | No |
| 694 | 5895 | 2947.5 | 174.8 | 87.4 | Adherence to medication. | Lars Osterberg, Terrence Blaschke | N Engl J Med | 2005 | 16079372 | No |
| 695 | 2947 | 2947.0 | 67.9 | 67.9 | Inflammatory bowel disease. | Daniel K Podolsky | N Engl J Med | 2002 | 12167685 | No |
| 696 | 2944 | 2944.0 | 73.9 | 73.9 | P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation. | Berk Hess | J Chem Theory Comput | 2008 | 26619985 | Yes |
| 697 | 2942 | 2942.0 | 62.3 | 62.3 | Principles of CDK regulation. | D O Morgan | Nature | 1995 | 7877684 | No |
| 698 | 2930 | 2930.0 | 71.8 | 71.8 | Chemokines--chemotactic cytokines that mediate inflammation. | A D Luster | N Engl J Med | 1998 | 9459648 | No |
| 699 | 2930 | 2930.0 | 73.7 | 73.7 | An index to quantify an individual's scientific research output. | J E Hirsch | Proc Natl Acad Sci U S A | 2005 | 16275915 | Yes |
| 700 | 5857 | 2928.5 | 202.4 | 101.2 | The biofilm matrix. | Hans-Curt Flemming, Jost Wingender | Nat Rev Microbiol | 2010 | 20676145 | No |
| 701 | 8784 | 2928.0 | 256.3 | 85.4 | Quantum mechanical continuum solvation models. | Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi | Chem Rev | 2005 | 16092826 | Yes |
| 702 | 5848 | 2924.0 | 186.8 | 93.4 | Accurate and simple analytic representation of the electron-gas correlation energy. | J P Perdew, Y Wang | Phys Rev B Condens Matter | 1992 | 10001404 | Yes |
| 703 | 2924 | 2924.0 | 68.0 | 68.0 | Bone resorption by osteoclasts. | S L Teitelbaum | Science | 2000 | 10968780 | No |
| 704 | 8748 | 2916.0 | 0.0 | 0.0 | The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. | R J Havel, H A Eder, J H Bragdon | J Clin Invest | 1955 | 13252080 | Yes |
| 705 | 8742 | 2914.0 | 271.9 | 90.6 | Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. | Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar | J Phys Chem B | 2009 | 19366259 | Yes |
| 706 | 5827 | 2913.5 | 263.3 | 131.7 | Revised methods for the Salmonella mutagenicity test. | D M Maron, B N Ames | Mutat Res | 1983 | 6341825 | Yes |
| 707 | 5825 | 2912.5 | 116.7 | 58.4 | Establishment in culture of pluripotential cells from mouse embryos. | M J Evans, M H Kaufman | Nature | 1981 | 7242681 | Yes |
| 708 | 2912 | 2912.0 | 71.4 | 71.4 | Phase separation of integral membrane proteins in Triton X-114 solution. | C Bordier | J Biol Chem | 1981 | 6257680 | Yes |
| 709 | 2910 | 2910.0 | 102.2 | 102.2 | Role of oxidative stress in development of complications in diabetes. | J W Baynes | Diabetes | 1991 | 2010041 | No |
| 710 | 5818 | 2909.0 | 168.3 | 84.2 | Inositol trisphosphate, a novel second messenger in cellular signal transduction. | M J Berridge, R F Irvine | Nature | 1984 | 6095092 | No |
| 711 | 5807 | 2903.5 | 203.1 | 101.5 | A method of comparing the areas under receiver operating characteristic curves derived from the same cases. | J A Hanley, B J McNeil | Radiology | 1983 | 6878708 | Yes |
| 712 | 2903 | 2903.0 | 79.8 | 79.8 | Predictive reward signal of dopamine neurons. | W Schultz | J Neurophysiol | 1998 | 9658025 | No |
| 713 | 2902 | 2902.0 | 97.2 | 97.2 | A computational approach to edge detection. | J Canny | IEEE Trans Pattern Anal Mach Intell | 1986 | 21869365 | Yes |
| 714 | 2901 | 2901.0 | 134.2 | 134.2 | Detecting alcoholism. The CAGE questionnaire. | J A Ewing | JAMA | 1984 | 6471323 | Yes |
| 715 | 2901 | 2901.0 | 190.7 | 190.7 | User's guide to correlation coefficients. | Haldun Akoglu | Turk J Emerg Med | 2018 | 30191186 | No |
| 716 | 2900 | 2900.0 | 0.0 | 0.0 | Notes on sugar determination. | M Smogyi | J Biol Chem | 1952 | 14938350 | Yes |
| 717 | 2898 | 2898.0 | 155.9 | 155.9 | Determination and quantification of content validity. | M R Lynn | Nurs Res | 1986 | 3640358 | Yes |
| 718 | 2896 | 2896.0 | 115.2 | 115.2 | UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. | D W Russell | J Pers Assess | 1996 | 8576833 | Yes |
| 719 | 5790 | 2895.0 | 0.0 | 0.0 | Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. | J D Watson, F H Crick | Nature | 1953 | 13054692 | Yes |
| 720 | 8683 | 2894.3 | 247.6 | 82.5 | Cortical surface-based analysis. I. Segmentation and surface reconstruction. | A M Dale, B Fischl, M I Sereno | Neuroimage | 1999 | 9931268 | Yes |
| 721 | 2893 | 2893.0 | 130.0 | 130.0 | Qualitative research. Introducing focus groups. | J Kitzinger | BMJ | 1995 | 7633241 | Yes |
| 722 | 2893 | 2893.0 | 62.9 | 62.9 | Telomere measurement by quantitative PCR. | Richard M Cawthon | Nucleic Acids Res | 2002 | 12000852 | Yes |
| 723 | 2892 | 2892.0 | 0.0 | 0.0 | A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. | E A Gehan | Biometrika | 1965 | 14341275 | Yes |
| 724 | 5780 | 2890.0 | 154.5 | 77.2 | Reactive oxygen species: metabolism, oxidative stress, and signal transduction. | Klaus Apel, Heribert Hirt | Annu Rev Plant Biol | 2004 | 15377225 | No |
| 725 | 2889 | 2889.0 | 67.1 | 67.1 | Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. | G P Smith | Science | 1985 | 4001944 | Yes |
| 726 | 8658 | 2886.0 | 382.7 | 127.6 | Scoping studies: advancing the methodology. | Danielle Levac, Heather Colquhoun, Kelly K O'Brien | Implement Sci | 2010 | 20854677 | Yes |
| 727 | 2885 | 2885.0 | 75.4 | 75.4 | A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. | Pascal Fries | Trends Cogn Sci | 2005 | 16150631 | No |
| 728 | 2884 | 2884.0 | 0.0 | 0.0 | Separation of leukocytes from blood and bone marrow. Introduction. | A Boyum | Scand J Clin Lab Invest Suppl | 1968 | 5707208 | Yes |
| 729 | 46108 | 2881.8 | 1475.9 | 92.2 | Fiji: an open-source platform for biological-image analysis. | Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona | Nat Methods | 2012 | 22743772 | Yes |
| 730 | 5762 | 2881.0 | 163.8 | 81.9 | Rapid isolation of high molecular weight plant DNA. | M G Murray, W F Thompson | Nucleic Acids Res | 1980 | 7433111 | Yes |
| 731 | 2880 | 2880.0 | 111.4 | 111.4 | Missing data analysis: making it work in the real world. | John W Graham | Annu Rev Psychol | 2009 | 18652544 | No |
| 732 | 8638 | 2879.3 | 243.1 | 81.0 | trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. | Salvador Capella-Gutierrez, Jose M Silla-Martinez, Toni Gabaldon | Bioinformatics | 2009 | 19505945 | Yes |
| 733 | 2879 | 2879.0 | 78.8 | 78.8 | Intestinal mucosal barrier function in health and disease. | Jerrold R Turner | Nat Rev Immunol | 2009 | 19855405 | No |
| 734 | 2878 | 2878.0 | 51.4 | 51.4 | One-step gene disruption in yeast. | R J Rothstein | Methods Enzymol | 1983 | 6310324 | Yes |
| 735 | 11468 | 2867.0 | 298.5 | 74.6 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. | C A Lipinski, F Lombardo, B W Dominy, P J Feeney | Adv Drug Deliv Rev | 2001 | 11259830 | No |
| 736 | 2861 | 2861.0 | 0.0 | 0.0 | Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. | W C Schneider | J Biol Chem | 1945 | 21005736 | Yes |
| 737 | 5712 | 2856.0 | 188.7 | 94.3 | PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. | Daniel R Roe, Thomas E Cheatham | J Chem Theory Comput | 2013 | 26583988 | Yes |
| 738 | 5706 | 2853.0 | 137.6 | 68.8 | A scaling normalization method for differential expression analysis of RNA-seq data. | Mark D Robinson, Alicia Oshlack | Genome Biol | 2010 | 20196867 | Yes |
| 739 | 8555 | 2851.7 | 240.7 | 80.2 | Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. | G Fairbanks, T L Steck, D F Wallach | Biochemistry | 1971 | 4326772 | Yes |
| 740 | 5701 | 2850.5 | 213.0 | 106.5 | Longitudinal data analysis for discrete and continuous outcomes. | S L Zeger, K Y Liang | Biometrics | 1986 | 3719049 | Yes |
| 741 | 2849 | 2849.0 | 78.3 | 78.3 | Inferring the historical patterns of biological evolution. | M Pagel | Nature | 1999 | 10553904 | Yes |
| 742 | 2849 | 2849.0 | 72.4 | 72.4 | Memory--a century of consolidation. | J L McGaugh | Science | 2000 | 10634773 | No |
| 743 | 2846 | 2846.0 | 91.5 | 91.5 | Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. | Peter C Austin | Pharm Stat | 2011 | 20925139 | Yes |
| 744 | 2842 | 2842.0 | 84.7 | 84.7 | A simple technique for demonstrating centromeric heterochromatin. | A T Sumner | Exp Cell Res | 1972 | 4117921 | Yes |
| 745 | 5681 | 2840.5 | 118.9 | 59.5 | Innate immune recognition. | Charles A Janeway, Ruslan Medzhitov | Annu Rev Immunol | 2002 | 11861602 | No |
| 746 | 8520 | 2840.0 | 227.4 | 75.8 | Immunity, inflammation, and cancer. | Sergei I Grivennikov, Florian R Greten, Michael Karin | Cell | 2010 | 20303878 | No |
| 747 | 2836 | 2836.0 | 0.0 | 0.0 | Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. | B E Murphy | J Clin Endocrinol Metab | 1967 | 4291524 | Yes |
| 748 | 5667 | 2833.5 | 150.3 | 75.2 | ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. | B Ravel, M Newville | J Synchrotron Radiat | 2005 | 15968136 | Yes |
| 749 | 2833 | 2833.0 | 0.0 | 0.0 | A study of the adrenotropic receptors. | R P Ahlquist | Am J Physiol | 1948 | 18882199 | Yes |
| 750 | 5660 | 2830.0 | 0.0 | 0.0 | Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. | J Glowinski, L L Iversen | J Neurochem | 1966 | 5950056 | Yes |
| 751 | 2830 | 2830.0 | 67.3 | 67.3 | Vascular endothelial growth factor: basic science and clinical progress. | Napoleone Ferrara | Endocr Rev | 2004 | 15294883 | No |
| 752 | 2830 | 2830.0 | 117.9 | 117.9 | Deep learning in neural networks: an overview. | Jurgen Schmidhuber | Neural Netw | 2015 | 25462637 | No |
| 753 | 5659 | 2829.5 | 139.4 | 69.7 | Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. | F W Studier, B A Moffatt | J Mol Biol | 1986 | 3537305 | Yes |
| 754 | 2829 | 2829.0 | 68.9 | 68.9 | Prostaglandins and leukotrienes: advances in eicosanoid biology. | C D Funk | Science | 2001 | 11729303 | No |
| 755 | 2826 | 2826.0 | 0.0 | 0.0 | Satellite cell of skeletal muscle fibers. | A Mauro | J Biophys Biochem Cytol | 1961 | 13768451 | Yes |
| 756 | 2826 | 2826.0 | 77.1 | 77.1 | A theory of cortical responses. | Karl Friston | Philos Trans R Soc Lond B Biol Sci | 2005 | 15937014 | No |
| 757 | 5651 | 2825.5 | 140.6 | 70.3 | Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. | D Hanahan, J Folkman | Cell | 1996 | 8756718 | No |
| 758 | 2823 | 2823.0 | 68.3 | 68.3 | Molecular chaperones in cellular protein folding. | F U Hartl | Nature | 1996 | 8637592 | No |
| 759 | 5635 | 2817.5 | 0.0 | 0.0 | Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. | J Silness, H Loe | Acta Odontol Scand | 1964 | 14158464 | Yes |
| 760 | 5629 | 2814.5 | 156.2 | 78.1 | UniFrac: a new phylogenetic method for comparing microbial communities. | Catherine Lozupone, Rob Knight | Appl Environ Microbiol | 2005 | 16332807 | Yes |
| 761 | 5626 | 2813.0 | 0.0 | 0.0 | A modified uronic acid carbazole reaction. | T Bitter, H M Muir | Anal Biochem | 1962 | 13971270 | Yes |
| 762 | 5617 | 2808.5 | 153.9 | 77.0 | Alzheimer's disease: the amyloid cascade hypothesis. | J A Hardy, G A Higgins | Science | 1992 | 1566067 | No |
| 763 | 2808 | 2808.0 | 84.2 | 84.2 | Two-sided confidence intervals for the single proportion: comparison of seven methods. | R G Newcombe | Stat Med | 1998 | 9595616 | Yes |
| 764 | 2807 | 2807.0 | 58.8 | 58.8 | On the number of segregating sites in genetical models without recombination. | G A Watterson | Theor Popul Biol | 1975 | 1145509 | Yes |
| 765 | 5611 | 2805.5 | 153.5 | 76.8 | The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. | J Vieira, J Messing | Gene | 1982 | 6295879 | Yes |
| 766 | 11222 | 2805.5 | 385.6 | 96.4 | Establishing a standard definition for child overweight and obesity worldwide: international survey. | T J Cole, M C Bellizzi, K M Flegal, W H Dietz | BMJ | 2000 | 10797032 | Yes |
| 767 | 5601 | 2800.5 | 134.1 | 67.0 | Caspases: enemies within. | N A Thornberry, Y Lazebnik | Science | 1998 | 9721091 | No |
| 768 | 2800 | 2800.0 | 54.4 | 54.4 | Mechanisms of type-I- and type-II-interferon-mediated signalling. | Leonidas C Platanias | Nat Rev Immunol | 2005 | 15864272 | No |
| 769 | 11200 | 2800.0 | 347.3 | 86.8 | Cancer statistics, 2010. | Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth Ward | CA Cancer J Clin | 2010 | 20610543 | Yes |
| 770 | 5598 | 2799.0 | 187.9 | 94.0 | Deciphering key features in protein structures with the new ENDscript server. | Xavier Robert, Patrice Gouet | Nucleic Acids Res | 2014 | 24753421 | Yes |
| 771 | 8396 | 2798.7 | 214.6 | 71.5 | RNA-Seq: a revolutionary tool for transcriptomics. | Zhong Wang, Mark Gerstein, Michael Snyder | Nat Rev Genet | 2009 | 19015660 | No |
| 772 | 5597 | 2798.5 | 0.0 | 0.0 | The Social Readjustment Rating Scale. | T H Holmes, R H Rahe | J Psychosom Res | 1967 | 6059863 | Yes |
| 773 | 2798 | 2798.0 | 69.3 | 69.3 | Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. | S A Bustin | J Mol Endocrinol | 2000 | 11013345 | No |
| 774 | 2795 | 2795.0 | 64.6 | 64.6 | Cell adhesion: the molecular basis of tissue architecture and morphogenesis. | B M Gumbiner | Cell | 1996 | 8608588 | No |
| 775 | 2795 | 2795.0 | 56.8 | 56.8 | The danger model: a renewed sense of self. | Polly Matzinger | Science | 2002 | 11951032 | Yes |
| 776 | 2793 | 2793.0 | 70.0 | 70.0 | MYC on the path to cancer. | Chi V Dang | Cell | 2012 | 22464321 | No |
| 777 | 2793 | 2793.0 | 120.9 | 120.9 | The brain's default mode network. | Marcus E Raichle | Annu Rev Neurosci | 2015 | 25938726 | No |
| 778 | 5580 | 2790.0 | 0.0 | 0.0 | A method for determining the sedimentation behavior of enzymes: application to protein mixtures. | R G Martin, B N Ames | J Biol Chem | 1961 | 13767412 | Yes |
| 779 | 5578 | 2789.0 | 205.3 | 102.7 | A feature-integration theory of attention. | A M Treisman, G Gelade | Cogn Psychol | 1980 | 7351125 | Yes |
| 780 | 5577 | 2788.5 | 173.0 | 86.5 | Glutathione. | A Meister, M E Anderson | Annu Rev Biochem | 1983 | 6137189 | No |
| 781 | 2787 | 2787.0 | 82.6 | 82.6 | Infrared spectroscopy of proteins. | Andreas Barth | Biochim Biophys Acta | 2007 | 17692815 | No |
| 782 | 11141 | 2785.2 | 292.1 | 73.0 | Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. | P W Rigby, M Dieckmann, C Rhodes, P Berg | J Mol Biol | 1977 | 881736 | Yes |
| 783 | 2777 | 2777.0 | 60.9 | 60.9 | The distribution of secondary growths in cancer of the breast. 1889. | S Paget | Cancer Metastasis Rev | 1989 | 2673568 | No |
| 784 | 2777 | 2777.0 | 85.4 | 85.4 | Stereotaxic mapping of the monoamine pathways in the rat brain. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4109331 | Yes |
| 785 | 2777 | 2777.0 | 0.0 | 0.0 | Efficient trace-labelling of proteins with iodine. | A S McFARLANE | Nature | 1958 | 13566175 | Yes |
| 786 | 5553 | 2776.5 | 192.4 | 96.2 | Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). | Kathryn M Connor, Jonathan R T Davidson | Depress Anxiety | 2003 | 12964174 | Yes |
| 787 | 5542 | 2771.0 | 129.7 | 64.8 | Myeloid-derived suppressor cells as regulators of the immune system. | Dmitry I Gabrilovich, Srinivas Nagaraj | Nat Rev Immunol | 2009 | 19197294 | No |
| 788 | 2768 | 2768.0 | 79.3 | 79.3 | Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. | P Correa | Cancer Res | 1992 | 1458460 | No |
| 789 | 2765 | 2765.0 | 68.7 | 68.7 | Cell death during development of the nervous system. | R W Oppenheim | Annu Rev Neurosci | 1991 | 2031577 | No |
| 790 | 5528 | 2764.0 | 150.8 | 75.4 | A global optimisation method for robust affine registration of brain images. | M Jenkinson, S Smith | Med Image Anal | 2001 | 11516708 | Yes |
| 791 | 5528 | 2764.0 | 118.5 | 59.2 | MicroRNAs: small RNAs with a big role in gene regulation. | Lin He, Gregory J Hannon | Nat Rev Genet | 2004 | 15211354 | No |
| 792 | 5512 | 2756.0 | 112.0 | 56.0 | Untangling the ErbB signalling network. | Y Yarden, M X Sliwkowski | Nat Rev Mol Cell Biol | 2001 | 11252954 | No |
| 793 | 2756 | 2756.0 | 61.3 | 61.3 | Epigenetics in cancer. | Manel Esteller | N Engl J Med | 2008 | 18337604 | No |
| 794 | 2755 | 2755.0 | 0.0 | 0.0 | Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. | L Svennerholm | Biochim Biophys Acta | 1957 | 13436486 | Yes |
| 795 | 5505 | 2752.5 | 259.4 | 129.7 | Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. | N S Jacobson, P Truax | J Consult Clin Psychol | 1991 | 2002127 | Yes |
| 796 | 2750 | 2750.0 | 61.3 | 61.3 | Rab GTPases as coordinators of vesicle traffic. | Harald Stenmark | Nat Rev Mol Cell Biol | 2009 | 19603039 | No |
| 797 | 5489 | 2744.5 | 188.0 | 94.0 | SPSS and SAS procedures for estimating indirect effects in simple mediation models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods Instrum Comput | 2004 | 15641418 | Yes |
| 798 | 5486 | 2743.0 | 112.3 | 56.1 | High-efficiency transformation of mammalian cells by plasmid DNA. | C Chen, H Okayama | Mol Cell Biol | 1987 | 3670292 | Yes |
| 799 | 5485 | 2742.5 | 166.3 | 83.2 | Judgment under Uncertainty: Heuristics and Biases. | A Tversky, D Kahneman | Science | 1974 | 17835457 | Yes |
| 800 | 2742 | 2742.0 | 77.0 | 77.0 | Hypoxia-inducible factors in physiology and medicine. | Gregg L Semenza | Cell | 2012 | 22304911 | No |
| 801 | 2742 | 2742.0 | 144.6 | 144.6 | The Global Epidemic of the Metabolic Syndrome. | Mohammad G Saklayen | Curr Hypertens Rep | 2018 | 29480368 | No |
| 802 | 2741 | 2741.0 | 60.0 | 60.0 | Evolving concepts of rheumatoid arthritis. | Gary S Firestein | Nature | 2003 | 12748655 | No |
| 803 | 2737 | 2737.0 | 85.3 | 85.3 | Social determinants of health inequalities. | Michael Marmot | Lancet | 2005 | 15781105 | Yes |
| 804 | 2725 | 2725.0 | 54.4 | 54.4 | Tumour-educated macrophages promote tumour progression and metastasis. | Jeffrey W Pollard | Nat Rev Cancer | 2004 | 14708027 | No |
| 805 | 2719 | 2719.0 | 90.6 | 90.6 | What are the functional consequences of neurocognitive deficits in schizophrenia? | M F Green | Am J Psychiatry | 1996 | 8610818 | No |
| 806 | 2719 | 2719.0 | 87.4 | 87.4 | PsychoPy--Psychophysics software in Python. | Jonathan W Peirce | J Neurosci Methods | 2007 | 17254636 | Yes |
| 807 | 8153 | 2717.7 | 174.3 | 58.1 | Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. | C M Gorman, L F Moffat, B H Howard | Mol Cell Biol | 1982 | 6960240 | Yes |
| 808 | 10869 | 2717.2 | 251.9 | 63.0 | MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. | Kazutaka Katoh, Kazuharu Misawa, Kei-Ichi Kuma, Takashi Miyata | Nucleic Acids Res | 2002 | 12136088 | Yes |
| 809 | 2717 | 2717.0 | 69.1 | 69.1 | Immunological and inflammatory functions of the interleukin-1 family. | Charles A Dinarello | Annu Rev Immunol | 2009 | 19302047 | No |
| 810 | 5430 | 2715.0 | 188.5 | 94.2 | The neural basis of drug craving: an incentive-sensitization theory of addiction. | T E Robinson, K C Berridge | Brain Res Brain Res Rev | 1993 | 8401595 | No |
| 811 | 10847 | 2711.8 | 240.0 | 60.0 | Cluster analysis and display of genome-wide expression patterns. | M B Eisen, P T Spellman, P O Brown, D Botstein | Proc Natl Acad Sci U S A | 1998 | 9843981 | Yes |
| 812 | 2710 | 2710.0 | 80.1 | 80.1 | Formation and Structure of Self-Assembled Monolayers. | Abraham Ulman | Chem Rev | 1996 | 11848802 | Yes |
| 813 | 10826 | 2706.5 | 290.9 | 72.7 | GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. | Berk Hess, Carsten Kutzner, David Van Der Spoel, Erik Lindahl | J Chem Theory Comput | 2008 | 26620784 | Yes |
| 814 | 2704 | 2704.0 | 96.0 | 96.0 | Working memory. | A Baddeley | Science | 1992 | 1736359 | No |
| 815 | 5399 | 2699.5 | 139.8 | 69.9 | The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. | Karen Bedard, Karl-Heinz Krause | Physiol Rev | 2007 | 17237347 | No |
| 816 | 2697 | 2697.0 | 73.4 | 73.4 | Dominant forces in protein folding. | K A Dill | Biochemistry | 1990 | 2207096 | No |
| 817 | 2697 | 2697.0 | 67.7 | 67.7 | Cancer nanotechnology: opportunities and challenges. | Mauro Ferrari | Nat Rev Cancer | 2005 | 15738981 | No |
| 818 | 5393 | 2696.5 | 96.2 | 48.1 | A general method applicable to the search for similarities in the amino acid sequence of two proteins. | S B Needleman, C D Wunsch | J Mol Biol | 1970 | 5420325 | Yes |
| 819 | 2688 | 2688.0 | 0.0 | 0.0 | Evaluating the quality of medical care. | A Donabedian | Milbank Mem Fund Q | 1966 | 5338568 | No |
| 820 | 2687 | 2687.0 | 64.1 | 64.1 | The inflammatory reflex. | Kevin J Tracey | Nature | 2002 | 12490958 | No |
| 821 | 8060 | 2686.7 | 342.7 | 114.2 | The behaviour change wheel: a new method for characterising and designing behaviour change interventions. | Susan Michie, Maartje M Van Stralen, Robert West | Implement Sci | 2011 | 21513547 | No |
| 822 | 2685 | 2685.0 | 60.3 | 60.3 | Angiogenesis in life, disease and medicine. | Peter Carmeliet | Nature | 2005 | 16355210 | No |
| 823 | 2682 | 2682.0 | 70.1 | 70.1 | Using circular dichroism spectra to estimate protein secondary structure. | Norma J Greenfield | Nat Protoc | 2006 | 17406547 | Yes |
| 824 | 2682 | 2682.0 | 146.3 | 146.3 | Making sense of implementation theories, models and frameworks. | Per Nilsen | Implement Sci | 2015 | 25895742 | Yes |
| 825 | 8043 | 2681.0 | 218.8 | 72.9 | MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. | Sudhir Kumar, Koichiro Tamura, Masatoshi Nei | Brief Bioinform | 2004 | 15260895 | Yes |
| 826 | 2677 | 2677.0 | 95.8 | 95.8 | Perceived exertion as an indicator of somatic stress. | G Borg | Scand J Rehabil Med | 1970 | 5523831 | Yes |
| 827 | 2677 | 2677.0 | 129.2 | 129.2 | Structural Model Evaluation and Modification: An Interval Estimation Approach. | J H Steiger | Multivariate Behav Res | 1990 | 26794479 | Yes |
| 828 | 2671 | 2671.0 | 68.7 | 68.7 | The nerve growth factor 35 years later. | R Levi-Montalcini | Science | 1987 | 3306916 | No |
| 829 | 2667 | 2667.0 | 146.5 | 146.5 | Understanding Bland Altman analysis. | Davide Giavarina | Biochem Med (Zagreb) | 2015 | 26110027 | No |
| 830 | 2660 | 2660.0 | 78.2 | 78.2 | Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. | P Cuatrecasas | J Biol Chem | 1970 | 5432796 | Yes |
| 831 | 5318 | 2659.0 | 145.0 | 72.5 | Autophagy: renovation of cells and tissues. | Noboru Mizushima, Masaaki Komatsu | Cell | 2011 | 22078875 | No |
| 832 | 5314 | 2657.0 | 289.4 | 144.7 | OrthoFinder: phylogenetic orthology inference for comparative genomics. | David M Emms, Steven Kelly | Genome Biol | 2019 | 31727128 | Yes |
| 833 | 5304 | 2652.0 | 115.0 | 57.5 | Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. | L A Greene, A S Tischler | Proc Natl Acad Sci U S A | 1976 | 1065897 | Yes |
| 834 | 2651 | 2651.0 | 107.3 | 107.3 | Neutrophil extracellular traps in immunity and disease. | Venizelos Papayannopoulos | Nat Rev Immunol | 2018 | 28990587 | No |
| 835 | 2649 | 2649.0 | 81.9 | 81.9 | The biology of oxygen radicals. | I Fridovich | Science | 1978 | 210504 | Yes |
| 836 | 2648 | 2648.0 | 98.4 | 98.4 | Plant products as antimicrobial agents. | M M Cowan | Clin Microbiol Rev | 1999 | 10515903 | No |
| 837 | 2648 | 2648.0 | 73.2 | 73.2 | TGFβ signalling in context. | Joan Massague | Nat Rev Mol Cell Biol | 2012 | 22992590 | No |
| 838 | 7943 | 2647.7 | 250.9 | 83.6 | Bacterial biofilms: a common cause of persistent infections. | J W Costerton, P S Stewart, E P Greenberg | Science | 1999 | 10334980 | No |
| 839 | 5290 | 2645.0 | 121.1 | 60.5 | Signal integration in the endoplasmic reticulum unfolded protein response. | David Ron, Peter Walter | Nat Rev Mol Cell Biol | 2007 | 17565364 | No |
| 840 | 13165 | 2633.0 | 324.5 | 64.9 | Development and testing of a general amber force field. | Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case | J Comput Chem | 2004 | 15116359 | Yes |
| 841 | 5260 | 2630.0 | 108.2 | 54.1 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. | D Bonnet, J E Dick | Nat Med | 1997 | 9212098 | Yes |
| 842 | 5254 | 2627.0 | 172.3 | 86.2 | The L-arginine-nitric oxide pathway. | S Moncada, A Higgs | N Engl J Med | 1993 | 7504210 | No |
| 843 | 2626 | 2626.0 | 0.0 | 0.0 | The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. | M L Anson | J Gen Physiol | 1938 | 19873094 | Yes |
| 844 | 2625 | 2625.0 | 111.0 | 111.0 | The validity and practicality of sun-reactive skin types I through VI. | T B Fitzpatrick | Arch Dermatol | 1988 | 3377516 | Yes |
| 845 | 2624 | 2624.0 | 0.0 | 0.0 | The catecholamine hypothesis of affective disorders: a review of supporting evidence. | J J Schildkraut | Am J Psychiatry | 1965 | 5319766 | No |
| 846 | 5248 | 2624.0 | 158.3 | 79.2 | The number of people with glaucoma worldwide in 2010 and 2020. | H A Quigley, A T Broman | Br J Ophthalmol | 2006 | 16488940 | Yes |
| 847 | 5243 | 2621.5 | 118.8 | 59.4 | Signal transduction by receptors with tyrosine kinase activity. | A Ullrich, J Schlessinger | Cell | 1990 | 2158859 | No |
| 848 | 5240 | 2620.0 | 0.0 | 0.0 | Some quantitative uses of drug antagonists. | O Arunlakshana, H O Schild | Br J Pharmacol Chemother | 1959 | 13651579 | Yes |
| 849 | 2614 | 2614.0 | 100.0 | 100.0 | Qualitative research: standards, challenges, and guidelines. | K Malterud | Lancet | 2001 | 11513933 | Yes |
| 850 | 5224 | 2612.0 | 167.6 | 83.8 | A simple, rapid, and sensitive DNA assay procedure. | C Labarca, K Paigen | Anal Biochem | 1980 | 6158890 | Yes |
| 851 | 2610 | 2610.0 | 51.9 | 51.9 | Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. | Shimon Sakaguchi | Annu Rev Immunol | 2004 | 15032588 | No |
| 852 | 2607 | 2607.0 | 79.9 | 79.9 | Epidemiology of viral hepatitis and hepatocellular carcinoma. | Hashem B El-Serag | Gastroenterology | 2012 | 22537432 | No |
| 853 | 5214 | 2607.0 | 146.7 | 73.3 | Oncology meets immunology: the cancer-immunity cycle. | Daniel S Chen, Ira Mellman | Immunity | 2013 | 23890059 | No |
| 854 | 2605 | 2605.0 | 87.7 | 87.7 | Simplified calculation of body-surface area. | R D Mosteller | N Engl J Med | 1987 | 3657876 | Yes |
| 855 | 5207 | 2603.5 | 183.7 | 91.8 | Shifting the genomic gold standard for the prokaryotic species definition. | Michael Richter, Ramon Rossello-Mora | Proc Natl Acad Sci U S A | 2009 | 19855009 | Yes |
| 856 | 2602 | 2602.0 | 79.2 | 79.2 | A two process model of sleep regulation. | A A Borbely | Hum Neurobiol | 1982 | 7185792 | Yes |
| 857 | 5194 | 2597.0 | 168.3 | 84.2 | The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. | H P Misra, I Fridovich | J Biol Chem | 1972 | 4623845 | Yes |
| 858 | 2597 | 2597.0 | 56.6 | 56.6 | G1 phase progression: cycling on cue. | C J Sherr | Cell | 1994 | 7954821 | No |
| 859 | 5194 | 2597.0 | 182.3 | 91.2 | Missing data: our view of the state of the art. | Joseph L Schafer, John W Graham | Psychol Methods | 2002 | 12090408 | Yes |
| 860 | 2594 | 2594.0 | 83.0 | 83.0 | Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. | B Samuelsson | Science | 1983 | 6301011 | Yes |
| 861 | 20747 | 2593.4 | 837.4 | 104.7 | The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. | Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jorg Peplies, Frank Oliver Glockner | Nucleic Acids Res | 2013 | 23193283 | Yes |
| 862 | 5183 | 2591.5 | 148.4 | 74.2 | Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. | Michael D Fox, Marcus E Raichle | Nat Rev Neurosci | 2007 | 17704812 | No |
| 863 | 2591 | 2591.0 | 96.0 | 96.0 | Spinal and supraspinal factors in human muscle fatigue. | S C Gandevia | Physiol Rev | 2001 | 11581501 | No |
| 864 | 2588 | 2588.0 | 0.0 | 0.0 | Isolation by Distance. | S Wright | Genetics | 1943 | 17247074 | Yes |
| 865 | 5173 | 2586.5 | 0.0 | 0.0 | Periodontal Disease In Pregnancy. I. Prevalence And Severity. | H Loe, J Silness | Acta Odontol Scand | 1963 | 14121956 | Yes |
| 866 | 2585 | 2585.0 | 73.9 | 73.9 | Delayed neuronal death in the gerbil hippocampus following ischemia. | T Kirino | Brain Res | 1982 | 7093691 | Yes |
| 867 | 5163 | 2581.5 | 189.1 | 94.5 | Cancer immunotherapy using checkpoint blockade. | Antoni Ribas, Jedd D Wolchok | Science | 2018 | 29567705 | No |
| 868 | 2578 | 2578.0 | 74.6 | 74.6 | Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. | R D Pascual-Marqui | Methods Find Exp Clin Pharmacol | 2002 | 12575463 | No |
| 869 | 5150 | 2575.0 | 148.4 | 74.2 | Application of phylogenetic networks in evolutionary studies. | Daniel H Huson, David Bryant | Mol Biol Evol | 2006 | 16221896 | Yes |
| 870 | 5145 | 2572.5 | 164.6 | 82.3 | Neural mechanisms of selective visual attention. | R Desimone, J Duncan | Annu Rev Neurosci | 1995 | 7605061 | No |
| 871 | 2571 | 2571.0 | 83.8 | 83.8 | Hazards of heavy metal contamination. | Lars Jarup | Br Med Bull | 2003 | 14757716 | No |
| 872 | 2570 | 2570.0 | 0.0 | 0.0 | The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. | R R Porter | Biochem J | 1959 | 14434282 | Yes |
| 873 | 2569 | 2569.0 | 92.0 | 92.0 | The membrane actions of anesthetics and tranquilizers. | P Seeman | Pharmacol Rev | 1972 | 4565956 | No |
| 874 | 2566 | 2566.0 | 67.3 | 67.3 | The physiology of glucagon-like peptide 1. | Jens Juul Holst | Physiol Rev | 2007 | 17928588 | No |
| 875 | 2565 | 2565.0 | 67.6 | 67.6 | The blood-brain barrier in health and chronic neurodegenerative disorders. | Berislav V Zlokovic | Neuron | 2008 | 18215617 | No |
| 876 | 5126 | 2563.0 | 213.6 | 106.8 | A diagnostic interview: the schedule for affective disorders and schizophrenia. | J Endicott, R L Spitzer | Arch Gen Psychiatry | 1978 | 678037 | Yes |
| 877 | 5118 | 2559.0 | 209.3 | 104.7 | Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. | J V Durnin, J Womersley | Br J Nutr | 1974 | 4843734 | Yes |
| 878 | 2559 | 2559.0 | 78.4 | 78.4 | Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. | Leonardo Pantoni | Lancet Neurol | 2010 | 20610345 | No |
| 879 | 2558 | 2558.0 | 51.8 | 51.8 | Universal control mechanism regulating onset of M-phase. | P Nurse | Nature | 1990 | 2138713 | No |
| 880 | 2558 | 2558.0 | 0.0 | 0.0 | The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. | S Boyden | J Exp Med | 1962 | 13872176 | Yes |
| 881 | 2553 | 2553.0 | 0.0 | 0.0 | The information capacity of the human motor system in controlling the amplitude of movement. | P M Fitts | J Exp Psychol | 1954 | 13174710 | Yes |
| 882 | 2553 | 2553.0 | 0.0 | 0.0 | Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. | O Smithies | Biochem J | 1955 | 13276348 | Yes |
| 883 | 5102 | 2551.0 | 126.5 | 63.2 | Calculation of protein extinction coefficients from amino acid sequence data. | S C Gill, P H Von Hippel | Anal Biochem | 1989 | 2610349 | Yes |
| 884 | 2551 | 2551.0 | 68.4 | 68.4 | Animal mitochondrial genomes. | J L Boore | Nucleic Acids Res | 1999 | 10101183 | No |
| 885 | 10186 | 2546.5 | 214.4 | 53.6 | WebLogo: a sequence logo generator. | Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner | Genome Res | 2004 | 15173120 | Yes |
| 886 | 2546 | 2546.0 | 55.5 | 55.5 | Cisplatin: mode of cytotoxic action and molecular basis of resistance. | Zahid H Siddik | Oncogene | 2003 | 14576837 | No |
| 887 | 2545 | 2545.0 | 47.2 | 47.2 | Targeting RAS signalling pathways in cancer therapy. | Julian Downward | Nat Rev Cancer | 2003 | 12509763 | No |
| 888 | 5070 | 2535.0 | 138.6 | 69.3 | Nonparametric permutation tests for functional neuroimaging: a primer with examples. | Thomas E Nichols, Andrew P Holmes | Hum Brain Mapp | 2002 | 11747097 | Yes |
| 889 | 2535 | 2535.0 | 69.1 | 69.1 | Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. | Claudiu T Supuran | Nat Rev Drug Discov | 2008 | 18167490 | No |
| 890 | 2534 | 2534.0 | 94.3 | 94.3 | Eye movements in reading and information processing: 20 years of research. | K Rayner | Psychol Bull | 1998 | 9849112 | No |
| 891 | 5062 | 2531.0 | 165.8 | 82.9 | Random-effects models for longitudinal data. | N M Laird, J H Ware | Biometrics | 1982 | 7168798 | Yes |
| 892 | 10123 | 2530.8 | 490.7 | 122.7 | The Satisfaction With Life Scale. | E Diener, R A Emmons, R J Larsen, S Griffin | J Pers Assess | 1985 | 16367493 | Yes |
| 893 | 5060 | 2530.0 | 102.4 | 51.2 | CDK inhibitors: positive and negative regulators of G1-phase progression. | C J Sherr, J M Roberts | Genes Dev | 1999 | 10385618 | No |
| 894 | 7590 | 2530.0 | 284.8 | 94.9 | Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. | Jack Bowden, George Davey Smith, Stephen Burgess | Int J Epidemiol | 2015 | 26050253 | Yes |
| 895 | 2526 | 2526.0 | 115.3 | 115.3 | International classification of sleep disorders-third edition: highlights and modifications. | Michael J Sateia | Chest | 2014 | 25367475 | No |
| 896 | 10102 | 2525.5 | 237.9 | 59.5 | Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. | A Krogh, B Larsson, G Von Heijne, E L Sonnhammer | J Mol Biol | 2001 | 11152613 | Yes |
| 897 | 2525 | 2525.0 | 61.4 | 61.4 | Causes and consequences of microRNA dysregulation in cancer. | Carlo M Croce | Nat Rev Genet | 2009 | 19763153 | No |
| 898 | 10093 | 2523.2 | 393.8 | 98.5 | Common method biases in behavioral research: a critical review of the literature and recommended remedies. | Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P Podsakoff | J Appl Psychol | 2003 | 14516251 | No |
| 899 | 2523 | 2523.0 | 72.9 | 72.9 | Working memory: looking back and looking forward. | Alan Baddeley | Nat Rev Neurosci | 2003 | 14523382 | No |
| 900 | 2521 | 2521.0 | 47.1 | 47.1 | Wnt signaling and cancer. | P Polakis | Genes Dev | 2000 | 10921899 | No |
| 901 | 2520 | 2520.0 | 62.7 | 62.7 | Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. | E C Butcher | Cell | 1991 | 1760836 | No |
| 902 | 2520 | 2520.0 | 108.5 | 108.5 | Effective physician-patient communication and health outcomes: a review. | M A Stewart | CMAJ | 1995 | 7728691 | Yes |
| 903 | 2517 | 2517.0 | 56.6 | 56.6 | A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. | Douglas C Wallace | Annu Rev Genet | 2005 | 16285865 | No |
| 904 | 5034 | 2517.0 | 147.9 | 74.0 | Macrophage plasticity and polarization: in vivo veritas. | Antonio Sica, Alberto Mantovani | J Clin Invest | 2012 | 22378047 | No |
| 905 | 5033 | 2516.5 | 239.2 | 119.6 | Making sense of Cronbach's alpha. | Mohsen Tavakol, Reg Dennick | Int J Med Educ | 2011 | 28029643 | No |
| 906 | 7548 | 2516.0 | 268.3 | 89.4 | Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. | R L Spitzer, K Kroenke, J B Williams | JAMA | 1999 | 10568646 | Yes |
| 907 | 2516 | 2516.0 | 58.6 | 58.6 | Nitric oxide and the immune response. | C Bogdan | Nat Immunol | 2001 | 11577346 | No |
| 908 | 5029 | 2514.5 | 137.4 | 68.7 | Acute-phase proteins and other systemic responses to inflammation. | C Gabay, I Kushner | N Engl J Med | 1999 | 9971870 | No |
| 909 | 2514 | 2514.0 | 66.1 | 66.1 | Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. | Jane Glazebrook | Annu Rev Phytopathol | 2005 | 16078883 | No |
| 910 | 2513 | 2513.0 | 63.9 | 63.9 | The extracellular matrix: not just pretty fibrils. | Richard O Hynes | Science | 2009 | 19965464 | No |
| 911 | 5018 | 2509.0 | 117.5 | 58.8 | Brown adipose tissue: function and physiological significance. | Barbara Cannon, Jan Nedergaard | Physiol Rev | 2004 | 14715917 | No |
| 912 | 2508 | 2508.0 | 79.8 | 79.8 | Secretory products of macrophages. | C F Nathan | J Clin Invest | 1987 | 3543052 | No |
| 913 | 2508 | 2508.0 | 77.3 | 77.3 | Biofilms: microbial life on surfaces. | Rodney M Donlan | Emerg Infect Dis | 2002 | 12194761 | No |
| 914 | 2506 | 2506.0 | 46.0 | 46.0 | Java Treeview--extensible visualization of microarray data. | Alok J Saldanha | Bioinformatics | 2004 | 15180930 | Yes |
| 915 | 2504 | 2504.0 | 0.0 | 0.0 | Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. | T Higuchi | J Pharm Sci | 1963 | 14088963 | Yes |
| 916 | 2501 | 2501.0 | 92.9 | 92.9 | Human error: models and management. | J Reason | BMJ | 2000 | 10720363 | Yes |
| 917 | 2501 | 2501.0 | 0.0 | 0.0 | Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. | G Bertani | J Bacteriol | 1951 | 14888646 | Yes |
| 918 | 5001 | 2500.5 | 113.6 | 56.8 | AKT/PKB signaling: navigating downstream. | Brendan D Manning, Lewis C Cantley | Cell | 2007 | 17604717 | No |
| 919 | 2500 | 2500.0 | 149.1 | 149.1 | The assessment of clinical skills/competence/performance. | G E Miller | Acad Med | 1990 | 2400509 | Yes |
| 920 | 4994 | 2497.0 | 172.2 | 86.1 | Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. | James J Gross, Oliver P John | J Pers Soc Psychol | 2003 | 12916575 | Yes |
| 921 | 4986 | 2493.0 | 100.7 | 50.4 | The phosphatidylinositol 3-Kinase AKT pathway in human cancer. | Igor Vivanco, Charles L Sawyers | Nat Rev Cancer | 2002 | 12094235 | No |
| 922 | 7470 | 2490.0 | 170.9 | 57.0 | The biology of VEGF and its receptors. | Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter | Nat Med | 2003 | 12778165 | No |
| 923 | 4979 | 2489.5 | 125.9 | 63.0 | Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. | Michael T Lin, M Flint Beal | Nature | 2006 | 17051205 | No |
| 924 | 4976 | 2488.0 | 139.8 | 69.9 | Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. | P J Fraker, J C Speck | Biochem Biophys Res Commun | 1978 | 637870 | Yes |
| 925 | 2484 | 2484.0 | 74.5 | 74.5 | Epidemiology of insomnia: what we know and what we still need to learn. | Maurice M Ohayon | Sleep Med Rev | 2002 | 12531146 | Yes |
| 926 | 4962 | 2481.0 | 186.3 | 93.2 | mTOR Signaling in Growth, Metabolism, and Disease. | Robert A Saxton, David M Sabatini | Cell | 2017 | 28283069 | No |
| 927 | 4956 | 2478.0 | 103.4 | 51.7 | Lipid rafts and signal transduction. | K Simons, D Toomre | Nat Rev Mol Cell Biol | 2000 | 11413487 | No |
| 928 | 2477 | 2477.0 | 0.0 | 0.0 | Transduction of linked genetic characters of the host by bacteriophage P1. | E S Lennox | Virology | 1955 | 13267987 | Yes |
| 929 | 2474 | 2474.0 | 72.4 | 72.4 | The importance of selenium to human health. | M P Rayman | Lancet | 2000 | 10963212 | No |
| 930 | 4947 | 2473.5 | 134.3 | 67.2 | A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. | Y Matsumura, H Maeda | Cancer Res | 1986 | 2946403 | Yes |
| 931 | 7414 | 2471.3 | 248.0 | 82.7 | Estimating the mean and variance from the median, range, and the size of a sample. | Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo | BMC Med Res Methodol | 2005 | 15840177 | Yes |
| 932 | 2471 | 2471.0 | 86.7 | 86.7 | Oxygen-dependent microbial killing by phagocytes (first of two parts). | B M Babior | N Engl J Med | 1978 | 24176 | Yes |
| 933 | 2470 | 2470.0 | 48.9 | 48.9 | Getting started with yeast. | F Sherman | Methods Enzymol | 1991 | 2005794 | Yes |
| 934 | 2467 | 2467.0 | 57.4 | 57.4 | Gene finding in novel genomes. | Ian Korf | BMC Bioinformatics | 2004 | 15144565 | Yes |
| 935 | 2464 | 2464.0 | 55.2 | 55.2 | Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. | T Hunter | Cell | 1995 | 7834742 | No |
| 936 | 4920 | 2460.0 | 120.6 | 60.3 | Protein misfolding, functional amyloid, and human disease. | Fabrizio Chiti, Christopher M Dobson | Annu Rev Biochem | 2006 | 16756495 | No |
| 937 | 2459 | 2459.0 | 51.8 | 51.8 | The lasso method for variable selection in the Cox model. | R Tibshirani | Stat Med | 1997 | 9044528 | Yes |
| 938 | 4918 | 2459.0 | 147.0 | 73.5 | Software survey: VOSviewer, a computer program for bibliometric mapping. | Nees Jan Van Eck, Ludo Waltman | Scientometrics | 2010 | 20585380 | Yes |
| 939 | 2458 | 2458.0 | 75.8 | 75.8 | Matching methods for causal inference: A review and a look forward. | Elizabeth A Stuart | Stat Sci | 2010 | 20871802 | Yes |
| 940 | 4914 | 2457.0 | 144.2 | 72.1 | Distributed hierarchical processing in the primate cerebral cortex. | D J Felleman, D C Van Essen | Cereb Cortex | 1991 | 1822724 | No |
| 941 | 2455 | 2455.0 | 80.5 | 80.5 | Scaffolds in tissue engineering bone and cartilage. | D W Hutmacher | Biomaterials | 2000 | 11071603 | Yes |
| 942 | 2455 | 2455.0 | 88.2 | 88.2 | Cognitive reserve in ageing and Alzheimer's disease. | Yaakov Stern | Lancet Neurol | 2012 | 23079557 | No |
| 943 | 2453 | 2453.0 | 87.2 | 87.2 | Keratoconus. | Y S Rabinowitz | Surv Ophthalmol | 1998 | 9493273 | No |
| 944 | 2449 | 2449.0 | 65.4 | 65.4 | Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. | H G Gratzner | Science | 1982 | 7123245 | Yes |
| 945 | 7347 | 2449.0 | 229.0 | 76.3 | The brain's default network: anatomy, function, and relevance to disease. | Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter | Ann N Y Acad Sci | 2008 | 18400922 | No |
| 946 | 2446 | 2446.0 | 57.5 | 57.5 | Specification of cerebral cortical areas. | P Rakic | Science | 1988 | 3291116 | No |
| 947 | 2445 | 2445.0 | 55.7 | 55.7 | Social controls on cell survival and cell death. | M C Raff | Nature | 1992 | 1557121 | No |
| 948 | 4889 | 2444.5 | 203.8 | 101.9 | Self-rated health and mortality: a review of twenty-seven community studies. | E L Idler, Y Benyamini | J Health Soc Behav | 1997 | 9097506 | No |
| 949 | 4872 | 2436.0 | 189.0 | 94.5 | The attention system of the human brain. | M I Posner, S E Petersen | Annu Rev Neurosci | 1990 | 2183676 | No |
| 950 | 2436 | 2436.0 | 56.5 | 56.5 | Mitochondrial diseases in man and mouse. | D C Wallace | Science | 1999 | 10066162 | No |
| 951 | 4870 | 2435.0 | 135.0 | 67.5 | Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. | M Matsuda, R A DeFronzo | Diabetes Care | 1999 | 10480510 | Yes |
| 952 | 2434 | 2434.0 | 118.9 | 118.9 | Presidential Address-1976. Social support as a moderator of life stress. | S Cobb | Psychosom Med | 1976 | 981490 | Yes |
| 953 | 2432 | 2432.0 | 80.3 | 80.3 | Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. | F F Jobsis | Science | 1977 | 929199 | Yes |
| 954 | 2432 | 2432.0 | 53.8 | 53.8 | NOX enzymes and the biology of reactive oxygen. | J David Lambeth | Nat Rev Immunol | 2004 | 15039755 | No |
| 955 | 4863 | 2431.5 | 128.3 | 64.2 | The unfolded protein response: from stress pathway to homeostatic regulation. | Peter Walter, David Ron | Science | 2011 | 22116877 | No |
| 956 | 4861 | 2430.5 | 173.5 | 86.8 | Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. | Sarvajeet Singh Gill, Narendra Tuteja | Plant Physiol Biochem | 2010 | 20870416 | No |
| 957 | 2430 | 2430.0 | 66.7 | 66.7 | A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. | P Chomczynski | Biotechniques | 1993 | 7692896 | Yes |
| 958 | 4860 | 2430.0 | 106.3 | 53.1 | New functions for the matrix metalloproteinases in cancer progression. | Mikala Egeblad, Zena Werb | Nat Rev Cancer | 2002 | 11990853 | No |
| 959 | 2423 | 2423.0 | 0.0 | 0.0 | Muscle structure and theories of contraction. | A F Huxley | Prog Biophys Biophys Chem | 1957 | 13485191 | Yes |
| 960 | 4845 | 2422.5 | 131.9 | 66.0 | Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. | C W Elston, I O Ellis | Histopathology | 1991 | 1757079 | Yes |
| 961 | 2422 | 2422.0 | 53.7 | 53.7 | Molecular physiology of P2X receptors. | R Alan North | Physiol Rev | 2002 | 12270951 | No |
| 962 | 4844 | 2422.0 | 97.0 | 48.5 | Mechanisms of TGF-beta signaling from cell membrane to the nucleus. | Yigong Shi, Joan Massague | Cell | 2003 | 12809600 | No |
| 963 | 9682 | 2420.5 | 243.3 | 60.8 | Matrix elasticity directs stem cell lineage specification. | Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher | Cell | 2006 | 16923388 | Yes |
| 964 | 4838 | 2419.0 | 179.0 | 89.5 | ROS function in redox signaling and oxidative stress. | Michael Schieber, Navdeep S Chandel | Curr Biol | 2014 | 24845678 | No |
| 965 | 2417 | 2417.0 | 57.2 | 57.2 | A decade of molecular biology of retinoic acid receptors. | P Chambon | FASEB J | 1996 | 8801176 | No |
| 966 | 7240 | 2413.3 | 0.0 | 0.0 | On The Nature Of Allosteric Transitions: A Plausible Model. | J Monod, J Wyman, J P Changeux | J Mol Biol | 1965 | 14343300 | Yes |
| 967 | 2411 | 2411.0 | 100.9 | 100.9 | Approximate entropy as a measure of system complexity. | S M Pincus | Proc Natl Acad Sci U S A | 1991 | 11607165 | Yes |
| 968 | 4822 | 2411.0 | 133.4 | 66.7 | Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. | Marie-Christine Daniel, Didier Astruc | Chem Rev | 2004 | 14719978 | No |
| 969 | 4816 | 2408.0 | 264.9 | 132.4 | ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. | Emmanuel Paradis, Klaus Schliep | Bioinformatics | 2019 | 30016406 | Yes |
| 970 | 7221 | 2407.0 | 207.4 | 69.1 | Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. | F E Harrell, K L Lee, D B Mark | Stat Med | 1996 | 8668867 | No |
| 971 | 2407 | 2407.0 | 82.8 | 82.8 | A new automated colorimetric method for measuring total oxidant status. | Ozcan Erel | Clin Biochem | 2005 | 16214125 | Yes |
| 972 | 2406 | 2406.0 | 62.3 | 62.3 | Ischemic cell death in brain neurons. | P Lipton | Physiol Rev | 1999 | 10508238 | No |
| 973 | 4812 | 2406.0 | 105.3 | 52.6 | Mass spectrometry-based proteomics. | Ruedi Aebersold, Matthias Mann | Nature | 2003 | 12634793 | No |
| 974 | 4800 | 2400.0 | 148.7 | 74.3 | Mechanisms of salinity tolerance. | Rana Munns, Mark Tester | Annu Rev Plant Biol | 2008 | 18444910 | No |
| 975 | 4796 | 2398.0 | 91.8 | 45.9 | A novel genetic system to detect protein-protein interactions. | S Fields, O Song | Nature | 1989 | 2547163 | Yes |
| 976 | 2395 | 2395.0 | 74.4 | 74.4 | The episodic buffer: a new component of working memory? | A Baddeley | Trends Cogn Sci | 2000 | 11058819 | Yes |
| 977 | 2395 | 2395.0 | 49.7 | 49.7 | The molecular biology of memory storage: a dialogue between genes and synapses. | E R Kandel | Science | 2001 | 11691980 | No |
| 978 | 4786 | 2393.0 | 205.5 | 102.8 | Methods for the thematic synthesis of qualitative research in systematic reviews. | James Thomas, Angela Harden | BMC Med Res Methodol | 2008 | 18616818 | Yes |
| 979 | 4781 | 2390.5 | 128.2 | 64.1 | Measuring the thickness of the human cerebral cortex from magnetic resonance images. | B Fischl, A M Dale | Proc Natl Acad Sci U S A | 2000 | 10984517 | Yes |
| 980 | 2387 | 2387.0 | 51.6 | 51.6 | Comparison of the predicted and observed secondary structure of T4 phage lysozyme. | B W Matthews | Biochim Biophys Acta | 1975 | 1180967 | Yes |
| 981 | 2387 | 2387.0 | 95.0 | 95.0 | The Michigan alcoholism screening test: the quest for a new diagnostic instrument. | M L Selzer | Am J Psychiatry | 1971 | 5565851 | Yes |
| 982 | 2386 | 2386.0 | 45.6 | 45.6 | Shelterin: the protein complex that shapes and safeguards human telomeres. | Titia De Lange | Genes Dev | 2005 | 16166375 | No |
| 983 | 2383 | 2383.0 | 51.7 | 51.7 | Maintenance of C. elegans. | Theresa Stiernagle | WormBook | 2006 | 18050451 | No |
| 984 | 2381 | 2381.0 | 54.5 | 54.5 | Theta oscillations in the hippocampus. | Gyorgy Buzsaki | Neuron | 2002 | 11832222 | No |
| 985 | 2380 | 2380.0 | 82.5 | 82.5 | Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? | George A Bonanno | Am Psychol | 2004 | 14736317 | No |
| 986 | 2380 | 2380.0 | 72.5 | 72.5 | Trail Making Test A and B: normative data stratified by age and education. | Tom N Tombaugh | Arch Clin Neuropsychol | 2004 | 15010086 | Yes |
| 987 | 4759 | 2379.5 | 0.0 | 0.0 | Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. | R L Heath, L Packer | Arch Biochem Biophys | 1968 | 5655425 | Yes |
| 988 | 4755 | 2377.5 | 126.1 | 63.0 | The inflammasomes. | Kate Schroder, Jurg Tschopp | Cell | 2010 | 20303873 | No |
| 989 | 7125 | 2375.0 | 155.8 | 51.9 | EMBOSS: the European Molecular Biology Open Software Suite. | P Rice, I Longden, A Bleasby | Trends Genet | 2000 | 10827456 | Yes |
| 990 | 2375 | 2375.0 | 80.5 | 80.5 | Pro-resolving lipid mediators are leads for resolution physiology. | Charles N Serhan | Nature | 2014 | 24899309 | No |
| 991 | 7125 | 2375.0 | 243.9 | 81.3 | Complex heatmaps reveal patterns and correlations in multidimensional genomic data. | Zuguang Gu, Roland Eils, Matthias Schlesner | Bioinformatics | 2016 | 27207943 | Yes |
| 992 | 2373 | 2373.0 | 83.4 | 83.4 | Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. | W A Craig | Clin Infect Dis | 1998 | 9455502 | No |
| 993 | 4743 | 2371.5 | 202.5 | 101.2 | The Health Belief Model: a decade later. | N K Janz, M H Becker | Health Educ Q | 1984 | 6392204 | No |
| 994 | 4737 | 2368.5 | 109.4 | 54.7 | Death receptors: signaling and modulation. | A Ashkenazi, V M Dixit | Science | 1998 | 9721089 | No |
| 995 | 2366 | 2366.0 | 77.3 | 77.3 | Biodiesel from microalgae. | Yusuf Chisti | Biotechnol Adv | 2007 | 17350212 | No |
| 996 | 2365 | 2365.0 | 78.6 | 78.6 | A rapid radiochemical method for the determination of choline acetyltransferase. | F Fonnum | J Neurochem | 1975 | 1113118 | Yes |
| 997 | 4730 | 2365.0 | 212.1 | 106.0 | The MOS social support survey. | C D Sherbourne, A L Stewart | Soc Sci Med | 1991 | 2035047 | Yes |
| 998 | 4730 | 2365.0 | 0.0 | 0.0 | Variations in pattern of pubertal changes in girls. | W A Marshall, J M Tanner | Arch Dis Child | 1969 | 5785179 | Yes |
| 999 | 2361 | 2361.0 | 52.9 | 52.9 | Stereochemistry of cooperative effects in haemoglobin. | M F Perutz | Nature | 1970 | 5528785 | Yes |
| 1000 | 25961 | 2360.1 | 673.0 | 61.2 | PLINK: a tool set for whole-genome association and population-based linkage analyses. | Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W De Bakker, Mark J Daly, Pak C Sham | Am J Hum Genet | 2007 | 17701901 | Yes |
| 1001 | 2359 | 2359.0 | 60.7 | 60.7 | A model for receptor-regulated calcium entry. | J W Putney | Cell Calcium | 1986 | 2420465 | No |
| 1002 | 7077 | 2359.0 | 177.6 | 59.2 | APE: Analyses of Phylogenetics and Evolution in R language. | Emmanuel Paradis, Julien Claude, Korbinian Strimmer | Bioinformatics | 2004 | 14734327 | Yes |
| 1003 | 4714 | 2357.0 | 0.0 | 0.0 | On the size of the active site in proteases. I. Papain. | I Schechter, A Berger | Biochem Biophys Res Commun | 1967 | 6035483 | Yes |
| 1004 | 2355 | 2355.0 | 60.8 | 60.8 | RGD and other recognition sequences for integrins. | E Ruoslahti | Annu Rev Cell Dev Biol | 1996 | 8970741 | No |
| 1005 | 2354 | 2354.0 | 53.3 | 53.3 | The structure and regulation of protein phosphatases. | P Cohen | Annu Rev Biochem | 1989 | 2549856 | No |
| 1006 | 2354 | 2354.0 | 68.5 | 68.5 | phangorn: phylogenetic analysis in R. | Klaus Peter Schliep | Bioinformatics | 2011 | 21169378 | Yes |
| 1007 | 2354 | 2354.0 | 87.6 | 87.6 | Macrophage Polarization. | Peter J Murray | Annu Rev Physiol | 2017 | 27813830 | No |
| 1008 | 4707 | 2353.5 | 86.3 | 43.1 | The interpretation of protein structures: estimation of static accessibility. | B Lee, F M Richards | J Mol Biol | 1971 | 5551392 | Yes |
| 1009 | 4707 | 2353.5 | 136.3 | 68.2 | Extended-connectivity fingerprints. | David Rogers, Mathew Hahn | J Chem Inf Model | 2010 | 20426451 | Yes |
| 1010 | 4703 | 2351.5 | 91.8 | 45.9 | SIFT: Predicting amino acid changes that affect protein function. | Pauline C Ng, Steven Henikoff | Nucleic Acids Res | 2003 | 12824425 | Yes |
| 1011 | 4700 | 2350.0 | 182.1 | 91.0 | Sex differences in immune responses. | Sabra L Klein, Katie L Flanagan | Nat Rev Immunol | 2016 | 27546235 | No |
| 1012 | 2348 | 2348.0 | 56.4 | 56.4 | The anatomy and taxonomy of protein structure. | J S Richardson | Adv Protein Chem | 1981 | 7020376 | No |
| 1013 | 2347 | 2347.0 | 45.0 | 45.0 | Histone acetylation in chromatin structure and transcription. | M Grunstein | Nature | 1997 | 9311776 | No |
| 1014 | 2344 | 2344.0 | 69.5 | 69.5 | Interleukin-1 and interleukin-1 antagonism. | C A Dinarello | Blood | 1991 | 1826616 | No |
| 1015 | 2344 | 2344.0 | 89.0 | 89.0 | Specific impairments of planning. | T Shallice | Philos Trans R Soc Lond B Biol Sci | 1982 | 6125971 | Yes |
| 1016 | 2343 | 2343.0 | 71.4 | 71.4 | Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. | Berislav V Zlokovic | Nat Rev Neurosci | 2011 | 22048062 | No |
| 1017 | 2342 | 2342.0 | 62.7 | 62.7 | Drug-like properties and the causes of poor solubility and poor permeability. | C A Lipinski | J Pharmacol Toxicol Methods | 2000 | 11274893 | No |
| 1018 | 2342 | 2342.0 | 207.5 | 207.5 | Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. | Brent R Stockwell | Cell | 2022 | 35803244 | No |
| 1019 | 4682 | 2341.0 | 120.0 | 60.0 | A receptor-mediated pathway for cholesterol homeostasis. | M S Brown, J L Goldstein | Science | 1986 | 3513311 | No |
| 1020 | 2336 | 2336.0 | 60.2 | 60.2 | Pancreatic cancer. | Manuel Hidalgo | N Engl J Med | 2010 | 20427809 | No |
| 1021 | 4672 | 2336.0 | 208.3 | 104.2 | A simple practice guide for dose conversion between animals and human. | Anroop B Nair, Shery Jacob | J Basic Clin Pharm | 2016 | 27057123 | No |
| 1022 | 4670 | 2335.0 | 101.9 | 51.0 | Screening lambdagt recombinant clones by hybridization to single plaques in situ. | W D Benton, R W Davis | Science | 1977 | 322279 | Yes |
| 1023 | 2335 | 2335.0 | 104.9 | 104.9 | Hydrogel: Preparation, characterization, and applications: A review. | Enas M Ahmed | J Adv Res | 2015 | 25750745 | No |
| 1024 | 2335 | 2335.0 | 79.1 | 79.1 | Modeling Development and Disease with Organoids. | Hans Clevers | Cell | 2016 | 27315476 | No |
| 1025 | 7001 | 2333.7 | 210.9 | 70.3 | Glucose clamp technique: a method for quantifying insulin secretion and resistance. | R A DeFronzo, J D Tobin, R Andres | Am J Physiol | 1979 | 382871 | Yes |
| 1026 | 2332 | 2332.0 | 62.6 | 62.6 | Accurate description of van der Waals complexes by density functional theory including empirical corrections. | Stefan Grimme | J Comput Chem | 2004 | 15224390 | Yes |
| 1027 | 2332 | 2332.0 | 70.6 | 70.6 | Global epidemiology of oral and oropharyngeal cancer. | Saman Warnakulasuriya | Oral Oncol | 2009 | 18804401 | No |
| 1028 | 4661 | 2330.5 | 121.0 | 60.5 | Building better batteries. | M Armand, J M Tarascon | Nature | 2008 | 18256660 | No |
| 1029 | 2330 | 2330.0 | 77.1 | 77.1 | Reactive oxygen species and the central nervous system. | B Halliwell | J Neurochem | 1992 | 1402908 | No |
| 1030 | 2329 | 2329.0 | 78.0 | 78.0 | Calmodulin plays a pivotal role in cellular regulation. | W Y Cheung | Science | 1980 | 6243188 | No |
| 1031 | 2328 | 2328.0 | 55.0 | 55.0 | A clearer vision for in vivo imaging. | R Weissleder | Nat Biotechnol | 2001 | 11283581 | No |
| 1032 | 18600 | 2325.0 | 587.1 | 73.4 | The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. | Ziad S Nasreddine, Natalie A Phillips, Valerie Bedirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow | J Am Geriatr Soc | 2005 | 15817019 | Yes |
| 1033 | 2324 | 2324.0 | 97.1 | 97.1 | Role of Streptococcus mutans in human dental decay. | W J Loesche | Microbiol Rev | 1986 | 3540569 | No |
| 1034 | 4644 | 2322.0 | 100.0 | 50.0 | Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. | T V Bliss, T Lomo | J Physiol | 1973 | 4727084 | Yes |
| 1035 | 2321 | 2321.0 | 63.0 | 63.0 | Inositol phospholipids and cell surface receptor function. | R H Michell | Biochim Biophys Acta | 1975 | 164246 | No |
| 1036 | 2321 | 2321.0 | 75.2 | 75.2 | Fetal origins of coronary heart disease. | D J Barker | BMJ | 1995 | 7613432 | No |
| 1037 | 6963 | 2321.0 | 197.8 | 65.9 | Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. | Helga Thorvaldsdottir, James T Robinson, Jill P Mesirov | Brief Bioinform | 2013 | 22517427 | Yes |
| 1038 | 4639 | 2319.5 | 125.6 | 62.8 | Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. | R A Laskey, A D Mills | Eur J Biochem | 1975 | 1175627 | Yes |
| 1039 | 4636 | 2318.0 | 129.9 | 65.0 | Wnt/β-catenin signaling and disease. | Hans Clevers, Roel Nusse | Cell | 2012 | 22682243 | No |
| 1040 | 2317 | 2317.0 | 65.8 | 65.8 | What is cognitive reserve? Theory and research application of the reserve concept. | Yaakov Stern | J Int Neuropsychol Soc | 2002 | 11939702 | No |
| 1041 | 2315 | 2315.0 | 66.1 | 66.1 | Descending control of pain. | Mark J Millan | Prog Neurobiol | 2002 | 12034378 | No |
| 1042 | 2315 | 2315.0 | 66.8 | 66.8 | Hybrid porous solids: past, present, future. | Gerard Ferey | Chem Soc Rev | 2008 | 18197340 | Yes |
| 1043 | 2315 | 2315.0 | 0.0 | 0.0 | Analysis of tissue and arterial blood temperatures in the resting human forearm. | H H Pennes | J Appl Physiol | 1948 | 18887578 | Yes |
| 1044 | 4624 | 2312.0 | 112.7 | 56.4 | Regulation of the mevalonate pathway. | J L Goldstein, M S Brown | Nature | 1990 | 1967820 | No |
| 1045 | 2312 | 2312.0 | 118.7 | 118.7 | Subjective well-being. | E Diener | Psychol Bull | 1984 | 6399758 | No |
| 1046 | 4616 | 2308.0 | 181.9 | 91.0 | Parkinson's disease. | Lorraine V Kalia, Anthony E Lang | Lancet | 2015 | 25904081 | No |
| 1047 | 4615 | 2307.5 | 0.0 | 0.0 | Loss of recent memory after bilateral hippocampal lesions. | W B Scoville, B Milner | J Neurol Neurosurg Psychiatry | 1957 | 13406589 | Yes |
| 1048 | 2307 | 2307.0 | 71.5 | 71.5 | Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. | R A DeFronzo | Diabetes | 1988 | 3289989 | No |
| 1049 | 4611 | 2305.5 | 0.0 | 0.0 | High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. | M N Berry, D S Friend | J Cell Biol | 1969 | 4900611 | Yes |
| 1050 | 4610 | 2305.0 | 93.2 | 46.6 | Smad-dependent and Smad-independent pathways in TGF-beta family signalling. | Rik Derynck, Ying E Zhang | Nature | 2003 | 14534577 | No |
| 1051 | 2303 | 2303.0 | 59.7 | 59.7 | Dopamine, learning and motivation. | Roy A Wise | Nat Rev Neurosci | 2004 | 15152198 | No |
| 1052 | 2302 | 2302.0 | 59.2 | 59.2 | Bcl-2 and the regulation of programmed cell death. | J C Reed | J Cell Biol | 1994 | 8294493 | No |
| 1053 | 2299 | 2299.0 | 58.5 | 58.5 | Metabolomics--the link between genotypes and phenotypes. | Oliver Fiehn | Plant Mol Biol | 2002 | 11860207 | No |
| 1054 | 2293 | 2293.0 | 51.6 | 51.6 | Follicular helper CD4 T cells (TFH). | Shane Crotty | Annu Rev Immunol | 2011 | 21314428 | No |
| 1055 | 9168 | 2292.0 | 378.4 | 94.6 | jModelTest 2: more models, new heuristics and parallel computing. | Diego Darriba, Guillermo L Taboada, Ramon Doallo, David Posada | Nat Methods | 2012 | 22847109 | Yes |
| 1056 | 4581 | 2290.5 | 103.3 | 51.6 | The DNA-damage response in human biology and disease. | Stephen P Jackson, Jiri Bartek | Nature | 2009 | 19847258 | No |
| 1057 | 4581 | 2290.5 | 189.3 | 94.7 | The amyloid hypothesis of Alzheimer's disease at 25 years. | Dennis J Selkoe, John Hardy | EMBO Mol Med | 2016 | 27025652 | No |
| 1058 | 2290 | 2290.0 | 55.3 | 55.3 | Pathways towards and away from Alzheimer's disease. | Mark P Mattson | Nature | 2004 | 15295589 | No |
| 1059 | 2289 | 2289.0 | 52.0 | 52.0 | Complement. First of two parts. | M J Walport | N Engl J Med | 2001 | 11287977 | No |
| 1060 | 2283 | 2283.0 | 80.9 | 80.9 | Glutamate, nitric oxide and cell-cell signalling in the nervous system. | J Garthwaite | Trends Neurosci | 1991 | 1708538 | No |
| 1061 | 2282 | 2282.0 | 45.3 | 45.3 | SV40-transformed simian cells support the replication of early SV40 mutants. | Y Gluzman | Cell | 1981 | 6260373 | Yes |
| 1062 | 2280 | 2280.0 | 0.0 | 0.0 | [Rapid physiological coagulation method in determination of fibrinogen]. | A Clauss | Acta Haematol | 1957 | 13434757 | Yes |
| 1063 | 4559 | 2279.5 | 139.8 | 69.9 | EQ-5D: a measure of health status from the EuroQol Group. | R Rabin, F De Charro | Ann Med | 2001 | 11491192 | No |
| 1064 | 2276 | 2276.0 | 66.2 | 66.2 | Superoxide radical and superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1995 | 7574505 | No |
| 1065 | 4549 | 2274.5 | 209.7 | 104.8 | Sensitivity Analysis in Observational Research: Introducing the E-Value. | Tyler J VanderWeele, Peng Ding | Ann Intern Med | 2017 | 28693043 | Yes |
| 1066 | 6822 | 2274.0 | 225.3 | 75.1 | Management of hepatocellular carcinoma: an update. | Jordi Bruix, Morris Sherman, | Hepatology | 2011 | 21374666 | No |
| 1067 | 2273 | 2273.0 | 76.9 | 76.9 | Grounded cognition. | Lawrence W Barsalou | Annu Rev Psychol | 2008 | 17705682 | No |
| 1068 | 4545 | 2272.5 | 87.3 | 43.6 | The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. | J A Spudich, S Watt | J Biol Chem | 1971 | 4254541 | Yes |
| 1069 | 2272 | 2272.0 | 100.6 | 100.6 | The Children's Depression, Inventory (CDI). | M Kovacs | Psychopharmacol Bull | 1985 | 4089116 | Yes |
| 1070 | 2272 | 2272.0 | 58.7 | 58.7 | Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. | Gokhan S Hotamisligil | Cell | 2010 | 20303879 | No |
| 1071 | 13614 | 2269.0 | 311.7 | 51.9 | NMRPipe: a multidimensional spectral processing system based on UNIX pipes. | F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax | J Biomol NMR | 1995 | 8520220 | Yes |
| 1072 | 2265 | 2265.0 | 54.0 | 54.0 | Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. | Scott L Friedman | Physiol Rev | 2008 | 18195085 | No |
| 1073 | 4529 | 2264.5 | 142.9 | 71.5 | Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9167458 | Yes |
| 1074 | 2264 | 2264.0 | 60.5 | 60.5 | The molecular pathology of Alzheimer's disease. | D J Selkoe | Neuron | 1991 | 1673054 | No |
| 1075 | 2264 | 2264.0 | 70.4 | 70.4 | Determination of minimum inhibitory concentrations. | J M Andrews | J Antimicrob Chemother | 2001 | 11420333 | Yes |
| 1076 | 4527 | 2263.5 | 110.8 | 55.4 | Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. | Hashem B El-Serag, K Lenhard Rudolph | Gastroenterology | 2007 | 17570226 | No |
| 1077 | 4526 | 2263.0 | 145.8 | 72.9 | A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. | Gary J Bennett, Y K Xie | Pain | 1988 | 2837713 | Yes |
| 1078 | 4522 | 2261.0 | 172.1 | 86.0 | ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. | M Gardes, T D Bruns | Mol Ecol | 1993 | 8180733 | Yes |
| 1079 | 11303 | 2260.6 | 369.5 | 73.9 | The hallmarks of aging. | Carlos Lopez-Otin, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer | Cell | 2013 | 23746838 | No |
| 1080 | 2259 | 2259.0 | 0.0 | 0.0 | Application of a microtechnique to viral serological investigations. | J L Sever | J Immunol | 1962 | 13910995 | Yes |
| 1081 | 4516 | 2258.0 | 105.8 | 52.9 | Issues and challenges facing rechargeable lithium batteries. | J M Tarascon, M Armand | Nature | 2001 | 11713543 | Yes |
| 1082 | 4514 | 2257.0 | 0.0 | 0.0 | A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. | J E Till, E A McCULLOCH | Radiat Res | 1961 | 13776896 | Yes |
| 1083 | 2255 | 2255.0 | 46.8 | 46.8 | Intracellular aspects of the process of protein synthesis. | G Palade | Science | 1975 | 1096303 | No |
| 1084 | 2254 | 2254.0 | 58.2 | 58.2 | Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. | Edward V Loftus | Gastroenterology | 2004 | 15168363 | Yes |
| 1085 | 2253 | 2253.0 | 55.5 | 55.5 | Protein kinase C and lipid signaling for sustained cellular responses. | Y Nishizuka | FASEB J | 1995 | 7737456 | No |
| 1086 | 4504 | 2252.0 | 89.8 | 44.9 | Network biology: understanding the cell's functional organization. | Albert-Laszlo Barabasi, Zoltan N Oltvai | Nat Rev Genet | 2004 | 14735121 | No |
| 1087 | 2252 | 2252.0 | 65.0 | 65.0 | Aging, cellular senescence, and cancer. | Judith Campisi | Annu Rev Physiol | 2013 | 23140366 | No |
| 1088 | 2250 | 2250.0 | 88.6 | 88.6 | Electroimmuno assay. | C B Laurell | Scand J Clin Lab Invest Suppl | 1972 | 4114358 | Yes |
| 1089 | 2249 | 2249.0 | 89.3 | 89.3 | International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. | C Herrmann | J Psychosom Res | 1997 | 9055211 | No |
| 1090 | 4497 | 2248.5 | 104.7 | 52.4 | A simple and very efficient method for generating cDNA libraries. | U Gubler, B J Hoffman | Gene | 1983 | 6198242 | Yes |
| 1091 | 2247 | 2247.0 | 56.4 | 56.4 | Pathogen recognition and inflammatory signaling in innate immune defenses. | Trine H Mogensen | Clin Microbiol Rev | 2009 | 19366914 | No |
| 1092 | 15723 | 2246.1 | 480.8 | 68.7 | AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. | Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson | J Comput Chem | 2009 | 19399780 | Yes |
| 1093 | 2246 | 2246.0 | 89.6 | 89.6 | Optical properties of biological tissues: a review. | Steven L Jacques | Phys Med Biol | 2013 | 23666068 | No |
| 1094 | 2244 | 2244.0 | 0.0 | 0.0 | The Gingival Index, the Plaque Index and the Retention Index Systems. | H Loe | J Periodontol | 1967 | 5237684 | Yes |
| 1095 | 2244 | 2244.0 | 57.4 | 57.4 | Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. | J Kyhse-Andersen | J Biochem Biophys Methods | 1984 | 6530509 | Yes |
| 1096 | 2243 | 2243.0 | 64.0 | 64.0 | Molecular diversity of glutamate receptors and implications for brain function. | S Nakanishi | Science | 1992 | 1329206 | No |
| 1097 | 2241 | 2241.0 | 79.5 | 79.5 | Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. | B N Ames | Science | 1983 | 6351251 | No |
| 1098 | 4479 | 2239.5 | 112.7 | 56.4 | Neuronal oscillations in cortical networks. | Gyorgy Buzsaki, Andreas Draguhn | Science | 2004 | 15218136 | No |
| 1099 | 2238 | 2238.0 | 77.6 | 77.6 | A classification of glycosyl hydrolases based on amino acid sequence similarities. | B Henrissat | Biochem J | 1991 | 1747104 | Yes |
| 1100 | 2237 | 2237.0 | 50.6 | 50.6 | The regulation of AP-1 activity by mitogen-activated protein kinases. | M Karin | J Biol Chem | 1995 | 7622446 | No |
| 1101 | 2237 | 2237.0 | 88.2 | 88.2 | Whatever next? Predictive brains, situated agents, and the future of cognitive science. | Andy Clark | Behav Brain Sci | 2013 | 23663408 | No |
| 1102 | 2236 | 2236.0 | 68.0 | 68.0 | Diagnosis of Alzheimer's disease. | Z S Khachaturian | Arch Neurol | 1985 | 2864910 | Yes |
| 1103 | 2234 | 2234.0 | 58.5 | 58.5 | Python: a programming language for software integration and development. | M F Sanner | J Mol Graph Model | 1999 | 10660911 | Yes |
| 1104 | 4465 | 2232.5 | 95.0 | 47.5 | 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? | George Davey Smith, Shah Ebrahim | Int J Epidemiol | 2003 | 12689998 | No |
| 1105 | 4461 | 2230.5 | 105.6 | 52.8 | The Bcl-2 protein family: arbiters of cell survival. | J M Adams, S Cory | Science | 1998 | 9735050 | No |
| 1106 | 2230 | 2230.0 | 90.8 | 90.8 | Perception of risk. | P Slovic | Science | 1987 | 3563507 | Yes |
| 1107 | 2230 | 2230.0 | 95.9 | 95.9 | A systematic method for clinical description and classification of personality variants. A proposal. | C R Cloninger | Arch Gen Psychiatry | 1987 | 3579504 | Yes |
| 1108 | 2229 | 2229.0 | 60.0 | 60.0 | Systemic lupus erythematosus. | George C Tsokos | N Engl J Med | 2011 | 22129255 | No |
| 1109 | 4452 | 2226.0 | 98.6 | 49.3 | Organization and expression of eucaryotic split genes coding for proteins. | R Breathnach, P Chambon | Annu Rev Biochem | 1981 | 6791577 | No |
| 1110 | 4448 | 2224.0 | 157.8 | 78.9 | The Emerging Hallmarks of Cancer Metabolism. | Natalya N Pavlova, Craig B Thompson | Cell Metab | 2016 | 26771115 | No |
| 1111 | 8895 | 2223.8 | 222.6 | 55.6 | Cancer-related inflammation. | Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill | Nature | 2008 | 18650914 | No |
| 1112 | 2222 | 2222.0 | 54.6 | 54.6 | Mechanisms and genes of cellular suicide. | H Steller | Science | 1995 | 7878463 | No |
| 1113 | 2220 | 2220.0 | 87.3 | 87.3 | Mechanisms of action of transmitters and other substances on smooth muscle. | T B Bolton | Physiol Rev | 1979 | 37533 | No |
| 1114 | 15526 | 2218.0 | 489.0 | 69.9 | The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. | Erik Von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gotzsche, Jan P Vandenbroucke, | Lancet | 2007 | 18064739 | Yes |
| 1115 | 2216 | 2216.0 | 81.5 | 81.5 | Selenium and human health. | Margaret P Rayman | Lancet | 2012 | 22381456 | No |
| 1116 | 2215 | 2215.0 | 80.2 | 80.2 | Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. | H W Steinbusch | Neuroscience | 1981 | 7017455 | Yes |
| 1117 | 2215 | 2215.0 | 71.0 | 71.0 | Flavonoids as antioxidants. | P G Pietta | J Nat Prod | 2000 | 10924197 | No |
| 1118 | 2214 | 2214.0 | 73.8 | 73.8 | Cognitive reserve. | Yaakov Stern | Neuropsychologia | 2009 | 19467352 | No |
| 1119 | 6633 | 2211.0 | 174.4 | 58.1 | GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. | R A Jefferson, T A Kavanagh, M W Bevan | EMBO J | 1987 | 3327686 | Yes |
| 1120 | 6633 | 2211.0 | 235.7 | 78.6 | Multiple imputation using chained equations: Issues and guidance for practice. | Ian R White, Patrick Royston, Angela M Wood | Stat Med | 2011 | 21225900 | Yes |
| 1121 | 4421 | 2210.5 | 137.8 | 68.9 | Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. | Stephen M Smith, Thomas E Nichols | Neuroimage | 2009 | 18501637 | Yes |
| 1122 | 4420 | 2210.0 | 130.4 | 65.2 | Genome editing. The new frontier of genome engineering with CRISPR-Cas9. | Jennifer A Doudna, Emmanuelle Charpentier | Science | 2014 | 25430774 | No |
| 1123 | 4416 | 2208.0 | 132.6 | 66.3 | Polymyositis and dermatomyositis (first of two parts). | A Bohan, J B Peter | N Engl J Med | 1975 | 1090839 | No |
| 1124 | 8828 | 2207.0 | 306.8 | 76.7 | Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. | A J Hughes, S E Daniel, L Kilford, A J Lees | J Neurol Neurosurg Psychiatry | 1992 | 1564476 | Yes |
| 1125 | 2207 | 2207.0 | 0.0 | 0.0 | Removal of fatty acids from serum albumin by charcoal treatment. | R F Chen | J Biol Chem | 1967 | 6016603 | Yes |
| 1126 | 4412 | 2206.0 | 86.1 | 43.0 | The fundamental role of epigenetic events in cancer. | Peter A Jones, Stephen B Baylin | Nat Rev Genet | 2002 | 12042769 | No |
| 1127 | 8820 | 2205.0 | 237.0 | 59.2 | Improved optimization for the robust and accurate linear registration and motion correction of brain images. | Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith | Neuroimage | 2002 | 12377157 | Yes |
| 1128 | 2205 | 2205.0 | 72.1 | 72.1 | The emerging role of lncRNAs in cancer. | Maite Huarte | Nat Med | 2015 | 26540387 | No |
| 1129 | 6614 | 2204.7 | 219.2 | 73.1 | Molecular mechanisms of epithelial-mesenchymal transition. | Samy Lamouille, Jian Xu, Rik Derynck | Nat Rev Mol Cell Biol | 2014 | 24556840 | No |
| 1130 | 6613 | 2204.3 | 197.9 | 66.0 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. | C E Murry, R B Jennings, K A Reimer | Circulation | 1986 | 3769170 | Yes |
| 1131 | 2204 | 2204.0 | 69.7 | 69.7 | Prooxidant states and tumor promotion. | P A Cerutti | Science | 1985 | 2981433 | No |
| 1132 | 2204 | 2204.0 | 51.6 | 51.6 | Chemokines. | B J Rollins | Blood | 1997 | 9242519 | No |
| 1133 | 2204 | 2204.0 | 55.4 | 55.4 | Interfaces and the driving force of hydrophobic assembly. | David Chandler | Nature | 2005 | 16193038 | No |
| 1134 | 4408 | 2204.0 | 99.4 | 49.7 | ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. | Matthew D Wilkerson, D Neil Hayes | Bioinformatics | 2010 | 20427518 | Yes |
| 1135 | 4405 | 2202.5 | 104.1 | 52.0 | Liver fibrosis. | Ramon Bataller, David A Brenner | J Clin Invest | 2005 | 15690074 | No |
| 1136 | 8806 | 2201.5 | 414.2 | 103.5 | Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. | Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun Tong | BMC Med Res Methodol | 2014 | 25524443 | Yes |
| 1137 | 2200 | 2200.0 | 86.1 | 86.1 | Role of endothelium in responses of vascular smooth muscle. | R F Furchgott | Circ Res | 1983 | 6313250 | No |
| 1138 | 2200 | 2200.0 | 55.5 | 55.5 | Mechanisms of hepatic fibrogenesis. | Scott L Friedman | Gastroenterology | 2008 | 18471545 | No |
| 1139 | 2200 | 2200.0 | 89.0 | 89.0 | Machine Learning in Medicine. | Rahul C Deo | Circulation | 2015 | 26572668 | No |
| 1140 | 4398 | 2199.0 | 146.6 | 73.3 | Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. | R B Devereux, N Reichek | Circulation | 1977 | 138494 | Yes |
| 1141 | 4398 | 2199.0 | 88.7 | 44.4 | Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. | Rudolf Jaenisch, Adrian Bird | Nat Genet | 2003 | 12610534 | No |
| 1142 | 2199 | 2199.0 | 81.7 | 81.7 | AliView: a fast and lightweight alignment viewer and editor for large datasets. | Anders Larsson | Bioinformatics | 2014 | 25095880 | Yes |
| 1143 | 2198 | 2198.0 | 58.9 | 58.9 | Episodic memory: from mind to brain. | Endel Tulving | Annu Rev Psychol | 2002 | 11752477 | Yes |
| 1144 | 2198 | 2198.0 | 50.8 | 50.8 | Defensins: antimicrobial peptides of innate immunity. | Tomas Ganz | Nat Rev Immunol | 2003 | 12949495 | No |
| 1145 | 4376 | 2188.0 | 108.4 | 54.2 | Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. | G G Glenner, C W Wong | Biochem Biophys Res Commun | 1984 | 6375662 | Yes |
| 1146 | 4375 | 2187.5 | 182.7 | 91.3 | The integrative review: updated methodology. | Robin Whittemore, Kathleen Knafl | J Adv Nurs | 2005 | 16268861 | Yes |
| 1147 | 4371 | 2185.5 | 199.6 | 99.8 | Stages and processes of self-change of smoking: toward an integrative model of change. | J O Prochaska, C C DiClemente | J Consult Clin Psychol | 1983 | 6863699 | Yes |
| 1148 | 4370 | 2185.0 | 118.0 | 59.0 | Cutaneous wound healing. | A J Singer, R A Clark | N Engl J Med | 1999 | 10471461 | No |
| 1149 | 2185 | 2185.0 | 84.6 | 84.6 | Health consequences of intimate partner violence. | Jacquelyn C Campbell | Lancet | 2002 | 11965295 | No |
| 1150 | 2185 | 2185.0 | 73.4 | 73.4 | Functional and effective connectivity: a review. | Karl J Friston | Brain Connect | 2011 | 22432952 | No |
| 1151 | 4364 | 2182.0 | 132.9 | 66.5 | LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. | Roman A Laskowski, Mark B Swindells | J Chem Inf Model | 2011 | 21919503 | Yes |
| 1152 | 2181 | 2181.0 | 41.2 | 41.2 | NK cell recognition. | Lewis L Lanier | Annu Rev Immunol | 2005 | 15771571 | No |
| 1153 | 2180 | 2180.0 | 71.2 | 71.2 | Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. | Sergio Pecorelli | Int J Gynaecol Obstet | 2009 | 19367689 | No |
| 1154 | 4359 | 2179.5 | 168.4 | 84.2 | Pain assessment: global use of the Brief Pain Inventory. | C S Cleeland, K M Ryan | Ann Acad Med Singap | 1994 | 8080219 | No |
| 1155 | 4359 | 2179.5 | 313.3 | 156.7 | Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. | David J Newman, Gordon M Cragg | J Nat Prod | 2020 | 32162523 | No |
| 1156 | 6537 | 2179.0 | 224.3 | 74.8 | Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. | C Lord, M Rutter, A Le Couteur | J Autism Dev Disord | 1994 | 7814313 | Yes |
| 1157 | 6537 | 2179.0 | 177.7 | 59.2 | Fast model-based estimation of ancestry in unrelated individuals. | David H Alexander, John Novembre, Kenneth Lange | Genome Res | 2009 | 19648217 | Yes |
| 1158 | 4351 | 2175.5 | 243.2 | 121.6 | Interactive Tree Of Life (iTOL) v4: recent updates and new developments. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2019 | 30931475 | Yes |
| 1159 | 2175 | 2175.0 | 0.0 | 0.0 | The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. | D E Atkinson | Biochemistry | 1968 | 4972613 | Yes |
| 1160 | 6522 | 2174.0 | 124.2 | 41.4 | Control of regulatory T cell development by the transcription factor Foxp3. | Shohei Hori, Takashi Nomura, Shimon Sakaguchi | Science | 2003 | 12522256 | Yes |
| 1161 | 2173 | 2173.0 | 48.2 | 48.2 | Developmental regulation of the growth plate. | Henry M Kronenberg | Nature | 2003 | 12748651 | No |
| 1162 | 2172 | 2172.0 | 49.3 | 49.3 | Chemokines and leukocyte traffic. | M Baggiolini | Nature | 1998 | 9560152 | No |
| 1163 | 2172 | 2172.0 | 44.2 | 44.2 | DNA methylation and human disease. | Keith D Robertson | Nat Rev Genet | 2005 | 16136652 | No |
| 1164 | 4343 | 2171.5 | 138.8 | 69.4 | Event-related EEG/MEG synchronization and desynchronization: basic principles. | G Pfurtscheller, F H Lopes Da Silva | Clin Neurophysiol | 1999 | 10576479 | No |
| 1165 | 2171 | 2171.0 | 0.0 | 0.0 | On respiratory impairment in cancer cells. | O Warburg | Science | 1956 | 13351639 | Yes |
| 1166 | 2171 | 2171.0 | 85.8 | 85.8 | α-band oscillations, attention, and controlled access to stored information. | Wolfgang Klimesch | Trends Cogn Sci | 2012 | 23141428 | No |
| 1167 | 2170 | 2170.0 | 46.4 | 46.4 | Role of angiogenesis in tumor growth and metastasis. | Judah Folkman | Semin Oncol | 2002 | 12516034 | No |
| 1168 | 2169 | 2169.0 | 43.4 | 43.4 | Signalling pathways of the TNF superfamily: a double-edged sword. | Bharat B Aggarwal | Nat Rev Immunol | 2003 | 12949498 | No |
| 1169 | 8675 | 2168.8 | 346.0 | 86.5 | The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. | T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerstrom | Br J Addict | 1991 | 1932883 | Yes |
| 1170 | 2166 | 2166.0 | 45.7 | 45.7 | Metastasis to bone: causes, consequences and therapeutic opportunities. | Gregory R Mundy | Nat Rev Cancer | 2002 | 12154351 | No |
| 1171 | 2165 | 2165.0 | 0.0 | 0.0 | Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. | P Mitchell | Biol Rev Camb Philos Soc | 1966 | 5329743 | No |
| 1172 | 2165 | 2165.0 | 42.5 | 42.5 | Protein modules and signalling networks. | T Pawson | Nature | 1995 | 7531822 | No |
| 1173 | 4330 | 2165.0 | 183.0 | 91.5 | The Oswestry Disability Index. | J C Fairbank, P B Pynsent | Spine (Phila Pa 1976) | 2000 | 11074683 | Yes |
| 1174 | 4325 | 2162.5 | 0.0 | 0.0 | Genetic regulatory mechanisms in the synthesis of proteins. | F Jacob, J Monod | J Mol Biol | 1961 | 13718526 | Yes |
| 1175 | 6485 | 2161.7 | 277.5 | 92.5 | Shedding light on the cell biology of extracellular vesicles. | Guillaume Van Niel, Gisela D'Angelo, Graca Raposo | Nat Rev Mol Cell Biol | 2018 | 29339798 | No |
| 1176 | 2161 | 2161.0 | 52.6 | 52.6 | The retinal pigment epithelium in visual function. | Olaf Strauss | Physiol Rev | 2005 | 15987797 | No |
| 1177 | 4322 | 2161.0 | 142.1 | 71.0 | Regulation of microRNA biogenesis. | Minju Ha, V Narry Kim | Nat Rev Mol Cell Biol | 2014 | 25027649 | No |
| 1178 | 4318 | 2159.0 | 104.5 | 52.2 | Assembly of asparagine-linked oligosaccharides. | R Kornfeld, S Kornfeld | Annu Rev Biochem | 1985 | 3896128 | No |
| 1179 | 4318 | 2159.0 | 289.3 | 144.7 | WHO Declares COVID-19 a Pandemic. | Domenico Cucinotta, Maurizio Vanelli | Acta Biomed | 2020 | 32191675 | Yes |
| 1180 | 2156 | 2156.0 | 46.3 | 46.3 | Molecular bases for circadian clocks. | J C Dunlap | Cell | 1999 | 9988221 | No |
| 1181 | 2153 | 2153.0 | 0.0 | 0.0 | Sedimentation Studies Of The Size And Shape Of Dna. | F W Studier | J Mol Biol | 1965 | 14290352 | Yes |
| 1182 | 4305 | 2152.5 | 131.7 | 65.8 | Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. | J S Beckman, W H Koppenol | Am J Physiol | 1996 | 8944624 | No |
| 1183 | 15066 | 2152.3 | 361.3 | 51.6 | Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. | Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman | Genome Biol | 2002 | 12184808 | Yes |
| 1184 | 4304 | 2152.0 | 191.6 | 95.8 | The Brief Symptom Inventory: an introductory report. | L R Derogatis, N Melisaratos | Psychol Med | 1983 | 6622612 | Yes |
| 1185 | 6456 | 2152.0 | 403.0 | 134.3 | Sample Size in Qualitative Interview Studies: Guided by Information Power. | Kirsti Malterud, Volkert Dirk Siersma, Ann Dorrit Guassora | Qual Health Res | 2016 | 26613970 | Yes |
| 1186 | 4298 | 2149.0 | 172.6 | 86.3 | The need to belong: desire for interpersonal attachments as a fundamental human motivation. | R F Baumeister, M R Leary | Psychol Bull | 1995 | 7777651 | No |
| 1187 | 15033 | 2147.6 | 432.0 | 61.7 | BLAST+: architecture and applications. | Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L Madden | BMC Bioinformatics | 2009 | 20003500 | Yes |
| 1188 | 2147 | 2147.0 | 103.5 | 103.5 | Performance-oriented assessment of mobility problems in elderly patients. | M E Tinetti | J Am Geriatr Soc | 1986 | 3944402 | Yes |
| 1189 | 2147 | 2147.0 | 0.0 | 0.0 | A new specific color reaction of hexuronic acids. | Z Dische | J Biol Chem | 1947 | 20281638 | Yes |
| 1190 | 6440 | 2146.7 | 152.4 | 50.8 | MOLMOL: a program for display and analysis of macromolecular structures. | R Koradi, M Billeter, K Wuthrich | J Mol Graph | 1996 | 8744573 | Yes |
| 1191 | 4293 | 2146.5 | 109.8 | 54.9 | Regulation of chromatin by histone modifications. | Andrew J Bannister, Tony Kouzarides | Cell Res | 2011 | 21321607 | No |
| 1192 | 6436 | 2145.3 | 0.0 | 0.0 | Immunochemical quantitation of antigens by single radial immunodiffusion. | G Mancini, A O Carbonara, J F Heremans | Immunochemistry | 1965 | 4956917 | Yes |
| 1193 | 6435 | 2145.0 | 216.3 | 72.1 | Parallel organization of functionally segregated circuits linking basal ganglia and cortex. | G E Alexander, M R DeLong, P L Strick | Annu Rev Neurosci | 1986 | 3085570 | No |
| 1194 | 2145 | 2145.0 | 58.1 | 58.1 | From sensation to cognition. | M M Mesulam | Brain | 1998 | 9648540 | No |
| 1195 | 4290 | 2145.0 | 0.0 | 0.0 | A Simplified Lead Citrate Stain For Use In Electron Microscopy. | J H Venable, R Coggeshall | J Cell Biol | 1965 | 14287192 | Yes |
| 1196 | 2145 | 2145.0 | 51.5 | 51.5 | Integration, scaling, space-group assignment and post-refinement. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124693 | Yes |
| 1197 | 4289 | 2144.5 | 113.8 | 56.9 | The heat-shock proteins. | S Lindquist, E A Craig | Annu Rev Genet | 1988 | 2853609 | No |
| 1198 | 2144 | 2144.0 | 48.8 | 48.8 | Neutrophils and immunity: challenges and opportunities. | Carl Nathan | Nat Rev Immunol | 2006 | 16498448 | No |
| 1199 | 4287 | 2143.5 | 0.0 | 0.0 | A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. | R F Beers, I W Sizer | J Biol Chem | 1952 | 14938361 | Yes |
| 1200 | 2143 | 2143.0 | 67.3 | 67.3 | The unbiased estimation of number and sizes of arbitrary particles using the disector. | D C Sterio | J Microsc | 1984 | 6737468 | Yes |
| 1201 | 6425 | 2141.7 | 273.5 | 91.2 | Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. | B N Ames, J McCann, E Yamasaki | Mutat Res | 1975 | 768755 | Yes |
| 1202 | 10693 | 2138.6 | 522.5 | 104.5 | ModelFinder: fast model selection for accurate phylogenetic estimates. | Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt Von Haeseler, Lars S Jermiin | Nat Methods | 2017 | 28481363 | Yes |
| 1203 | 4276 | 2138.0 | 142.7 | 71.3 | Saliency, switching, attention and control: a network model of insula function. | Vinod Menon, Lucina Q Uddin | Brain Struct Funct | 2010 | 20512370 | No |
| 1204 | 6407 | 2135.7 | 293.3 | 97.8 | Radiomics: Images Are More than Pictures, They Are Data. | Robert J Gillies, Paul E Kinahan, Hedvig Hricak | Radiology | 2016 | 26579733 | Yes |
| 1205 | 2132 | 2132.0 | 46.6 | 46.6 | TRP channels as cellular sensors. | David E Clapham | Nature | 2003 | 14654832 | No |
| 1206 | 2131 | 2131.0 | 44.4 | 44.4 | DNA topoisomerases: structure, function, and mechanism. | J J Champoux | Annu Rev Biochem | 2001 | 11395412 | No |
| 1207 | 2131 | 2131.0 | 0.0 | 0.0 | Cognitive maps in rats and men. | E C Tolman | Psychol Rev | 1948 | 18870876 | Yes |
| 1208 | 4257 | 2128.5 | 110.8 | 55.4 | Function and activation of NF-kappa B in the immune system. | P A Baeuerle, T Henkel | Annu Rev Immunol | 1994 | 8011280 | No |
| 1209 | 8514 | 2128.5 | 353.3 | 88.3 | Guidelines for the process of cross-cultural adaptation of self-report measures. | D E Beaton, C Bombardier, F Guillemin, M B Ferraz | Spine (Phila Pa 1976) | 2000 | 11124735 | No |
| 1210 | 2128 | 2128.0 | 93.2 | 93.2 | A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. | E L Bradley | Arch Surg | 1993 | 8489394 | No |
| 1211 | 4254 | 2127.0 | 89.5 | 44.8 | Mammalian MAP kinase signalling cascades. | L Chang, M Karin | Nature | 2001 | 11242034 | No |
| 1212 | 2126 | 2126.0 | 64.3 | 64.3 | Cell biology and molecular basis of denitrification. | W G Zumft | Microbiol Mol Biol Rev | 1997 | 9409151 | No |
| 1213 | 17008 | 2126.0 | 443.0 | 55.4 | Electric field effect in atomically thin carbon films. | K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov | Science | 2004 | 15499015 | Yes |
| 1214 | 4251 | 2125.5 | 126.7 | 63.4 | Angiogenic factors. | J Folkman, M Klagsbrun | Science | 1987 | 2432664 | No |
| 1215 | 2124 | 2124.0 | 45.4 | 45.4 | Mammalian G1 cyclins. | C J Sherr | Cell | 1993 | 8513492 | No |
| 1216 | 4247 | 2123.5 | 86.1 | 43.0 | The Wnt signaling pathway in development and disease. | Catriona Y Logan, Roel Nusse | Annu Rev Cell Dev Biol | 2004 | 15473860 | No |
| 1217 | 4244 | 2122.0 | 87.6 | 43.8 | A guided tour into subcellular colocalization analysis in light microscopy. | S Bolte, F P Cordelieres | J Microsc | 2006 | 17210054 | Yes |
| 1218 | 14854 | 2122.0 | 348.4 | 49.8 | Induction of pluripotent stem cells from adult human fibroblasts by defined factors. | Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka | Cell | 2007 | 18035408 | Yes |
| 1219 | 2122 | 2122.0 | 46.6 | 46.6 | The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. | Michael R Lieber | Annu Rev Biochem | 2010 | 20192759 | No |
| 1220 | 2121 | 2121.0 | 0.0 | 0.0 | Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. | D Aminoff | Biochem J | 1961 | 13860975 | Yes |
| 1221 | 6358 | 2119.3 | 328.2 | 109.4 | Production, use, and fate of all plastics ever made. | Roland Geyer, Jenna R Jambeck, Kara Lavender Law | Sci Adv | 2017 | 28776036 | Yes |
| 1222 | 4237 | 2118.5 | 84.6 | 42.3 | Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. | M Gossen, H Bujard | Proc Natl Acad Sci U S A | 1992 | 1319065 | Yes |
| 1223 | 2117 | 2117.0 | 58.2 | 58.2 | Hydrogels for biomedical applications. | Allan S Hoffman | Adv Drug Deliv Rev | 2002 | 11755703 | No |
| 1224 | 2117 | 2117.0 | 84.5 | 84.5 | Periodontitis: from microbial immune subversion to systemic inflammation. | George Hajishengallis | Nat Rev Immunol | 2015 | 25534621 | No |
| 1225 | 2117 | 2117.0 | 108.2 | 108.2 | Stop Explaining Black Box Machine Learning Models for High Stakes Decisions and Use Interpretable Models Instead. | Cynthia Rudin | Nat Mach Intell | 2019 | 35603010 | Yes |
| 1226 | 2115 | 2115.0 | 50.6 | 50.6 | Patterns of amino acids near signal-sequence cleavage sites. | G Von Heijne | Eur J Biochem | 1983 | 6852022 | Yes |
| 1227 | 2115 | 2115.0 | 50.9 | 50.9 | DAMPs, PAMPs and alarmins: all we need to know about danger. | Marco E Bianchi | J Leukoc Biol | 2007 | 17032697 | No |
| 1228 | 4228 | 2114.0 | 93.9 | 47.0 | Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. | F Sallusto, A Lanzavecchia | J Exp Med | 1994 | 8145033 | Yes |
| 1229 | 8455 | 2113.8 | 0.0 | 0.0 | Antibiotic susceptibility testing by a standardized single disk method. | A W Bauer, W M Kirby, J C Sherris, M Turck | Am J Clin Pathol | 1966 | 5325707 | Yes |
| 1230 | 2113 | 2113.0 | 0.0 | 0.0 | The plasma lecithins:cholesterol acyltransferase reaction. | J A Glomset | J Lipid Res | 1968 | 4868699 | No |
| 1231 | 2113 | 2113.0 | 67.8 | 67.8 | Calculation of substrate oxidation rates in vivo from gaseous exchange. | K N Frayn | J Appl Physiol Respir Environ Exerc Physiol | 1983 | 6618956 | Yes |
| 1232 | 8451 | 2112.8 | 255.5 | 63.9 | Comorbidity measures for use with administrative data. | A Elixhauser, C Steiner, D R Harris, R M Coffey | Med Care | 1998 | 9431328 | Yes |
| 1233 | 6333 | 2111.0 | 202.8 | 67.6 | Arlequin (version 3.0): an integrated software package for population genetics data analysis. | Laurent Excoffier, Guillaume Laval, Stefan Schneider | Evol Bioinform Online | 2007 | 19325852 | Yes |
| 1234 | 2111 | 2111.0 | 69.3 | 69.3 | Cytokines in inflammatory bowel disease. | Markus F Neurath | Nat Rev Immunol | 2014 | 24751956 | No |
| 1235 | 2108 | 2108.0 | 67.5 | 67.5 | Multiple imputation: a primer. | J L Schafer | Stat Methods Med Res | 1999 | 10347857 | No |
| 1236 | 2108 | 2108.0 | 41.7 | 41.7 | Notch signalling: a simple pathway becomes complex. | Sarah J Bray | Nat Rev Mol Cell Biol | 2006 | 16921404 | No |
| 1237 | 4215 | 2107.5 | 111.8 | 55.9 | Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. | E Lander, L Kruglyak | Nat Genet | 1995 | 7581446 | Yes |
| 1238 | 4214 | 2107.0 | 105.2 | 52.6 | Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. | M Nei, T Gojobori | Mol Biol Evol | 1986 | 3444411 | Yes |
| 1239 | 2105 | 2105.0 | 58.5 | 58.5 | Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. | Ralph A Defronzo | Diabetes | 2009 | 19336687 | No |
| 1240 | 4208 | 2104.0 | 118.6 | 59.3 | Molecular mechanisms and clinical applications of angiogenesis. | Peter Carmeliet, Rakesh K Jain | Nature | 2011 | 21593862 | No |
| 1241 | 2102 | 2102.0 | 62.2 | 62.2 | Estimating causal effects from large data sets using propensity scores. | D B Rubin | Ann Intern Med | 1997 | 9382394 | No |
| 1242 | 2102 | 2102.0 | 43.2 | 43.2 | Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. | Shimon Sakaguchi | Nat Immunol | 2005 | 15785760 | No |
| 1243 | 2100 | 2100.0 | 77.7 | 77.7 | Determination of glutathione and glutathione disulfide in biological samples. | M E Anderson | Methods Enzymol | 1985 | 4088074 | Yes |
| 1244 | 12600 | 2100.0 | 311.2 | 51.9 | GROMACS: fast, flexible, and free. | David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen | J Comput Chem | 2005 | 16211538 | Yes |
| 1245 | 2099 | 2099.0 | 55.5 | 55.5 | Negative refraction makes a perfect lens | J B Pendry | Phys Rev Lett | 2000 | 11041972 | Yes |
| 1246 | 4197 | 2098.5 | 111.5 | 55.8 | ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. | Markus Wiederstein, Manfred J Sippl | Nucleic Acids Res | 2007 | 17517781 | Yes |
| 1247 | 2098 | 2098.0 | 75.0 | 75.0 | Epidemiological features of chronic low-back pain. | G B Andersson | Lancet | 1999 | 10470716 | No |
| 1248 | 2098 | 2098.0 | 50.4 | 50.4 | The genetics of ageing. | Cynthia J Kenyon | Nature | 2010 | 20336132 | No |
| 1249 | 2098 | 2098.0 | 78.6 | 78.6 | The global burden of IBD: from 2015 to 2025. | Gilaad G Kaplan | Nat Rev Gastroenterol Hepatol | 2015 | 26323879 | No |
| 1250 | 4191 | 2095.5 | 134.2 | 67.1 | Neutrophil recruitment and function in health and inflammation. | Elzbieta Kolaczkowska, Paul Kubes | Nat Rev Immunol | 2013 | 23435331 | No |
| 1251 | 2095 | 2095.0 | 41.3 | 41.3 | Approaching the asymptote? Evolution and revolution in immunology. | C A Janeway | Cold Spring Harb Symp Quant Biol | 1989 | 2700931 | No |
| 1252 | 6283 | 2094.3 | 215.5 | 71.8 | AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. | P G Reeves, F H Nielsen, G C Fahey | J Nutr | 1993 | 8229312 | No |
| 1253 | 4186 | 2093.0 | 98.4 | 49.2 | Parkinson's disease: mechanisms and models. | William Dauer, Serge Przedborski | Neuron | 2003 | 12971891 | No |
| 1254 | 2093 | 2093.0 | 58.2 | 58.2 | What we can do and what we cannot do with fMRI. | Nikos K Logothetis | Nature | 2008 | 18548064 | No |
| 1255 | 2092 | 2092.0 | 56.9 | 56.9 | The heme oxygenase system: a regulator of second messenger gases. | M D Maines | Annu Rev Pharmacol Toxicol | 1997 | 9131263 | No |
| 1256 | 2092 | 2092.0 | 0.0 | 0.0 | Method For Assay Of Intestinal Disaccharidases. | A Dahlqvist | Anal Biochem | 1964 | 14106916 | Yes |
| 1257 | 4179 | 2089.5 | 182.3 | 91.2 | Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. | A Y Finlay, G K Khan | Clin Exp Dermatol | 1994 | 8033378 | Yes |
| 1258 | 2089 | 2089.0 | 42.7 | 42.7 | Antiviral actions of interferons. | C E Samuel | Clin Microbiol Rev | 2001 | 11585785 | No |
| 1259 | 16709 | 2088.6 | 590.5 | 73.8 | GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. | Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schunemann, | BMJ | 2008 | 18436948 | Yes |
| 1260 | 4176 | 2088.0 | 86.0 | 43.0 | An automated method for finding molecular complexes in large protein interaction networks. | Gary D Bader, Christopher W V Hogue | BMC Bioinformatics | 2003 | 12525261 | Yes |
| 1261 | 4176 | 2088.0 | 147.2 | 73.6 | Understanding interobserver agreement: the kappa statistic. | Anthony J Viera, Joanne M Garrett | Fam Med | 2005 | 15883903 | Yes |
| 1262 | 2088 | 2088.0 | 59.8 | 59.8 | The origins of the developmental origins theory. | D J P Barker | J Intern Med | 2007 | 17444880 | No |
| 1263 | 2086 | 2086.0 | 88.5 | 88.5 | The drug abuse screening test. | H A Skinner | Addict Behav | 1982 | 7183189 | Yes |
| 1264 | 2086 | 2086.0 | 55.1 | 55.1 | Flow-mediated endothelial mechanotransduction. | P F Davies | Physiol Rev | 1995 | 7624393 | No |
| 1265 | 2086 | 2086.0 | 52.1 | 52.1 | Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. | B L Wajchenberg | Endocr Rev | 2000 | 11133069 | No |
| 1266 | 4168 | 2084.0 | 115.5 | 57.8 | New perspectives in cell adhesion: RGD and integrins. | E Ruoslahti, M D Pierschbacher | Science | 1987 | 2821619 | No |
| 1267 | 2084 | 2084.0 | 59.5 | 59.5 | The inverse care law. | J T Hart | Lancet | 1971 | 4100731 | Yes |
| 1268 | 4162 | 2081.0 | 163.6 | 81.8 | The transtheoretical model of health behavior change. | J O Prochaska, W F Velicer | Am J Health Promot | 1997 | 10170434 | No |
| 1269 | 2080 | 2080.0 | 50.0 | 50.0 | Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. | G Trinchieri | Annu Rev Immunol | 1995 | 7612223 | No |
| 1270 | 2080 | 2080.0 | 73.2 | 73.2 | Social relationships and health. | Sheldon Cohen | Am Psychol | 2004 | 15554821 | No |
| 1271 | 2079 | 2079.0 | 61.2 | 61.2 | ATP-regulated K+ channels in cardiac muscle. | A Noma | Nature | 1983 | 6310409 | Yes |
| 1272 | 2079 | 2079.0 | 62.5 | 62.5 | Introduction and General Overview of Cyclodextrin Chemistry. | Jozsef Szejtli | Chem Rev | 1998 | 11848947 | Yes |
| 1273 | 4157 | 2078.5 | 121.5 | 60.8 | Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. | M A Nitsche, W Paulus | J Physiol | 2000 | 10990547 | Yes |
| 1274 | 6229 | 2076.3 | 253.5 | 84.5 | Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. | G Muyzer, E C De Waal, A G Uitterlinden | Appl Environ Microbiol | 1993 | 7683183 | Yes |
| 1275 | 2076 | 2076.0 | 91.0 | 91.0 | A rating scale for drug-induced akathisia. | T R Barnes | Br J Psychiatry | 1989 | 2574607 | Yes |
| 1276 | 4150 | 2075.0 | 100.2 | 50.1 | Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. | B A Reynolds, S Weiss | Science | 1992 | 1553558 | Yes |
| 1277 | 4147 | 2073.5 | 144.2 | 72.1 | The benefits of being present: mindfulness and its role in psychological well-being. | Kirk Warren Brown, Richard M Ryan | J Pers Soc Psychol | 2003 | 12703651 | Yes |
| 1278 | 2073 | 2073.0 | 55.7 | 55.7 | Molecular dissection of reactive astrogliosis and glial scar formation. | Michael V Sofroniew | Trends Neurosci | 2009 | 19782411 | No |
| 1279 | 2072 | 2072.0 | 70.9 | 70.9 | The use of a plus-maze to measure anxiety in the mouse. | R G Lister | Psychopharmacology (Berl) | 1987 | 3110839 | Yes |
| 1280 | 2072 | 2072.0 | 65.9 | 65.9 | Sick individuals and sick populations. | G Rose | Int J Epidemiol | 1985 | 3872850 | Yes |
| 1281 | 2072 | 2072.0 | 0.0 | 0.0 | Dendritic organization in the neurons of the visual and motor cortices of the cat. | D A Sholl | J Anat | 1953 | 13117757 | Yes |
| 1282 | 2072 | 2072.0 | 0.0 | 0.0 | Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. | J C Skou | Physiol Rev | 1965 | 14337569 | No |
| 1283 | 2070 | 2070.0 | 36.3 | 36.3 | ATM and related protein kinases: safeguarding genome integrity. | Yosef Shiloh | Nat Rev Cancer | 2003 | 12612651 | No |
| 1284 | 2069 | 2069.0 | 43.4 | 43.4 | G1 events and regulation of cell proliferation. | A B Pardee | Science | 1989 | 2683075 | No |
| 1285 | 4135 | 2067.5 | 121.3 | 60.6 | The pathogenesis of rheumatoid arthritis. | Iain B McInnes, Georg Schett | N Engl J Med | 2011 | 22150039 | No |
| 1286 | 2067 | 2067.0 | 60.9 | 60.9 | Inhibited spontaneous emission in solid-state physics and electronics. | E Yablonovitch | Phys Rev Lett | 1987 | 10034639 | Yes |
| 1287 | 2067 | 2067.0 | 36.5 | 36.5 | Mechanisms of alternative pre-messenger RNA splicing. | Douglas L Black | Annu Rev Biochem | 2003 | 12626338 | No |
| 1288 | 10335 | 2067.0 | 475.3 | 95.1 | Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. | Daehwan Kim, Joseph M Paggi, Chanhee Park, Christopher Bennett, Steven L Salzberg | Nat Biotechnol | 2019 | 31375807 | Yes |
| 1289 | 2065 | 2065.0 | 0.0 | 0.0 | Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? | J V Neel | Am J Hum Genet | 1962 | 13937884 | Yes |
| 1290 | 4127 | 2063.5 | 0.0 | 0.0 | Plaque formation and isolation of pure lines with poliomyelitis viruses. | R Dulbecco, M Vogt | J Exp Med | 1954 | 13130792 | Yes |
| 1291 | 4126 | 2063.0 | 111.1 | 55.5 | Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering | S Nie, S R Emory | Science | 1997 | 9027306 | Yes |
| 1292 | 2063 | 2063.0 | 0.0 | 0.0 | The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. | W W Cleland | Biochim Biophys Acta | 1963 | 14021667 | Yes |
| 1293 | 4125 | 2062.5 | 111.4 | 55.7 | Mathematical model for studying genetic variation in terms of restriction endonucleases. | M Nei, W H Li | Proc Natl Acad Sci U S A | 1979 | 291943 | Yes |
| 1294 | 2062 | 2062.0 | 57.4 | 57.4 | Dengue and dengue hemorrhagic fever. | D J Gubler | Clin Microbiol Rev | 1998 | 9665979 | No |
| 1295 | 4124 | 2062.0 | 103.2 | 51.6 | Decision curve analysis: a novel method for evaluating prediction models. | Andrew J Vickers, Elena B Elkin | Med Decis Making | 2006 | 17099194 | Yes |
| 1296 | 6183 | 2061.0 | 195.3 | 65.1 | Simultaneous inference in general parametric models. | Torsten Hothorn, Frank Bretz, Peter Westfall | Biom J | 2008 | 18481363 | No |
| 1297 | 4115 | 2057.5 | 101.1 | 50.5 | The acute respiratory distress syndrome. | L B Ware, M A Matthay | N Engl J Med | 2000 | 10793167 | No |
| 1298 | 18517 | 2057.4 | 614.0 | 68.2 | The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. | , D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert | N Engl J Med | 1993 | 8366922 | Yes |
| 1299 | 4114 | 2057.0 | 115.4 | 57.7 | Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. | B J Marshall, J R Warren | Lancet | 1984 | 6145023 | Yes |
| 1300 | 4114 | 2057.0 | 156.6 | 78.3 | Alginate: properties and biomedical applications. | Kuen Yong Lee, David J Mooney | Prog Polym Sci | 2012 | 22125349 | Yes |
| 1301 | 4113 | 2056.5 | 89.2 | 44.6 | A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. | G Shaw, R Kamen | Cell | 1986 | 3488815 | Yes |
| 1302 | 2056 | 2056.0 | 41.3 | 41.3 | Systems biology: a brief overview. | Hiroaki Kitano | Science | 2002 | 11872829 | No |
| 1303 | 2055 | 2055.0 | 80.8 | 80.8 | Predicting basal metabolic rate, new standards and review of previous work. | W N Schofield | Hum Nutr Clin Nutr | 1985 | 4044297 | Yes |
| 1304 | 2055 | 2055.0 | 58.6 | 58.6 | Understanding organofluorine chemistry. An introduction to the C-F bond. | David O'Hagan | Chem Soc Rev | 2008 | 18197347 | No |
| 1305 | 2055 | 2055.0 | 86.2 | 86.2 | Oxidative stress: a concept in redox biology and medicine. | Helmut Sies | Redox Biol | 2015 | 25588755 | No |
| 1306 | 8219 | 2054.8 | 244.4 | 61.1 | Image quality assessment: from error visibility to structural similarity. | Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P Simoncelli | IEEE Trans Image Process | 2004 | 15376593 | Yes |
| 1307 | 2051 | 2051.0 | 62.4 | 62.4 | Protein oxidation and aging. | E R Stadtman | Science | 1992 | 1355616 | No |
| 1308 | 4101 | 2050.5 | 99.1 | 49.5 | Macrophage diversity enhances tumor progression and metastasis. | Bin-Zhi Qian, Jeffrey W Pollard | Cell | 2010 | 20371344 | No |
| 1309 | 2050 | 2050.0 | 0.0 | 0.0 | Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. | J W Littlefield | Science | 1964 | 14168277 | Yes |
| 1310 | 2049 | 2049.0 | 61.1 | 61.1 | Apoptosis in cancer: from pathogenesis to treatment. | Rebecca S Y Wong | J Exp Clin Cancer Res | 2011 | 21943236 | No |
| 1311 | 2049 | 2049.0 | 102.5 | 102.5 | DLS and zeta potential - What they are and what they are not? | Sourav Bhattacharjee | J Control Release | 2016 | 27297779 | No |
| 1312 | 4097 | 2048.5 | 111.6 | 55.8 | Protective and pathogenic functions of macrophage subsets. | Peter J Murray, Thomas A Wynn | Nat Rev Immunol | 2011 | 21997792 | No |
| 1313 | 2047 | 2047.0 | 46.0 | 46.0 | A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. | J SantaLucia | Proc Natl Acad Sci U S A | 1998 | 9465037 | Yes |
| 1314 | 2047 | 2047.0 | 60.1 | 60.1 | Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. | Robert E Marx | J Oral Maxillofac Surg | 2003 | 12966493 | Yes |
| 1315 | 4089 | 2044.5 | 99.3 | 49.6 | Base-calling of automated sequencer traces using phred. II. Error probabilities. | B Ewing, P Green | Genome Res | 1998 | 9521922 | Yes |
| 1316 | 2044 | 2044.0 | 72.7 | 72.7 | The polyvagal perspective. | Stephen W Porges | Biol Psychol | 2007 | 17049418 | No |
| 1317 | 8173 | 2043.2 | 203.1 | 50.8 | Epithelial-mesenchymal transitions in development and disease. | Jean Paul Thiery, Herve Acloque, Ruby Y J Huang, M Angela Nieto | Cell | 2009 | 19945376 | No |
| 1318 | 2043 | 2043.0 | 41.4 | 41.4 | The complex language of chromatin regulation during transcription. | Shelley L Berger | Nature | 2007 | 17522673 | No |
| 1319 | 4085 | 2042.5 | 122.4 | 61.2 | The precuneus: a review of its functional anatomy and behavioural correlates. | Andrea E Cavanna, Michael R Trimble | Brain | 2006 | 16399806 | No |
| 1320 | 6127 | 2042.3 | 132.2 | 44.1 | Adjusting batch effects in microarray expression data using empirical Bayes methods. | W Evan Johnson, Cheng Li, Ariel Rabinovic | Biostatistics | 2007 | 16632515 | Yes |
| 1321 | 12243 | 2040.5 | 376.9 | 62.8 | New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. | Stephane Guindon, Jean-Francois Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel | Syst Biol | 2010 | 20525638 | Yes |
| 1322 | 2037 | 2037.0 | 56.4 | 56.4 | Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. | B Winkel-Shirley | Plant Physiol | 2001 | 11402179 | No |
| 1323 | 2036 | 2036.0 | 48.0 | 48.0 | Interleukin-2: inception, impact, and implications. | K A Smith | Science | 1988 | 3131876 | No |
| 1324 | 12216 | 2036.0 | 394.0 | 65.7 | Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939837 | Yes |
| 1325 | 2035 | 2035.0 | 60.1 | 60.1 | Synergy, antagonism, and what the chequerboard puts between them. | F C Odds | J Antimicrob Chemother | 2003 | 12805255 | No |
| 1326 | 2034 | 2034.0 | 63.0 | 63.0 | Stress signalling pathways that impair prefrontal cortex structure and function. | Amy F T Arnsten | Nat Rev Neurosci | 2009 | 19455173 | No |
| 1327 | 2033 | 2033.0 | 43.4 | 43.4 | Mechanisms of cancer drug resistance. | Michael M Gottesman | Annu Rev Med | 2002 | 11818492 | No |
| 1328 | 2033 | 2033.0 | 63.9 | 63.9 | Stress and disorders of the stress system. | George P Chrousos | Nat Rev Endocrinol | 2009 | 19488073 | No |
| 1329 | 2032 | 2032.0 | 37.9 | 37.9 | In situ hybridization: an improved whole-mount method for Xenopus embryos. | R M Harland | Methods Cell Biol | 1991 | 1811161 | Yes |
| 1330 | 2032 | 2032.0 | 49.4 | 49.4 | Calcium signaling. | D E Clapham | Cell | 1995 | 7834745 | No |
| 1331 | 4062 | 2031.0 | 106.6 | 53.3 | Leptin and the regulation of body weight in mammals. | J M Friedman, J L Halaas | Nature | 1998 | 9796811 | No |
| 1332 | 4061 | 2030.5 | 102.0 | 51.0 | Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. | P Liang, A B Pardee | Science | 1992 | 1354393 | Yes |
| 1333 | 2030 | 2030.0 | 46.9 | 46.9 | Targeting PI3K signalling in cancer: opportunities, challenges and limitations. | Jeffrey A Engelman | Nat Rev Cancer | 2009 | 19629070 | No |
| 1334 | 4060 | 2030.0 | 137.8 | 68.9 | Elements of cancer immunity and the cancer-immune set point. | Daniel S Chen, Ira Mellman | Nature | 2017 | 28102259 | No |
| 1335 | 2029 | 2029.0 | 59.2 | 59.2 | The comet assay for DNA damage and repair: principles, applications, and limitations. | Andrew R Collins | Mol Biotechnol | 2004 | 15004294 | No |
| 1336 | 2028 | 2028.0 | 73.8 | 73.8 | A modified card sorting test sensitive to frontal lobe defects. | H E Nelson | Cortex | 1976 | 1009768 | Yes |
| 1337 | 2028 | 2028.0 | 53.0 | 53.0 | Determination and analysis of urea and guanidine hydrochloride denaturation curves. | C N Pace | Methods Enzymol | 1986 | 3773761 | Yes |
| 1338 | 2028 | 2028.0 | 49.6 | 49.6 | The global health burden of infection-associated cancers in the year 2002. | Donald Maxwell Parkin | Int J Cancer | 2006 | 16404738 | Yes |
| 1339 | 26359 | 2027.6 | 1038.6 | 79.9 | Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. | Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L Rehm, | Genet Med | 2015 | 25741868 | Yes |
| 1340 | 2027 | 2027.0 | 53.5 | 53.5 | Purinergic nerves. | G Burnstock | Pharmacol Rev | 1972 | 4404211 | No |
| 1341 | 4053 | 2026.5 | 129.9 | 65.0 | Efficient pseudopotentials for plane-wave calculations. | N Troullier, J L Martins | Phys Rev B Condens Matter | 1991 | 9997467 | Yes |
| 1342 | 2026 | 2026.0 | 63.4 | 63.4 | The atom economy--a search for synthetic efficiency. | B M Trost | Science | 1991 | 1962206 | Yes |
| 1343 | 2026 | 2026.0 | 57.8 | 57.8 | Analysis of bacteriophage T7 early RNAs and proteins on slab gels. | F W Studier | J Mol Biol | 1973 | 4760132 | Yes |
| 1344 | 2024 | 2024.0 | 64.4 | 64.4 | Ethical authorship and publishing. | Andrew J S Coats | Int J Cardiol | 2009 | 19046787 | No |
| 1345 | 2023 | 2023.0 | 62.4 | 62.4 | The role of senescent cells in ageing. | Jan M Van Deursen | Nature | 2014 | 24848057 | No |
| 1346 | 2023 | 2023.0 | 141.4 | 141.4 | The changing landscape of atherosclerosis. | Peter Libby | Nature | 2021 | 33883728 | No |
| 1347 | 10110 | 2022.0 | 246.2 | 49.2 | Mapping and quantifying mammalian transcriptomes by RNA-Seq. | Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold | Nat Methods | 2008 | 18516045 | Yes |
| 1348 | 4041 | 2020.5 | 88.5 | 44.2 | Lessons from hereditary colorectal cancer. | K W Kinzler, B Vogelstein | Cell | 1996 | 8861899 | No |
| 1349 | 4038 | 2019.0 | 126.3 | 63.1 | New method for quantitative determination of uronic acids. | N Blumenkrantz, G Asboe-Hansen | Anal Biochem | 1973 | 4269305 | Yes |
| 1350 | 2019 | 2019.0 | 0.0 | 0.0 | A theory of cerebellar cortex. | D Marr | J Physiol | 1969 | 5784296 | Yes |
| 1351 | 4038 | 2019.0 | 117.7 | 58.9 | CTFFIND4: Fast and accurate defocus estimation from electron micrographs. | Alexis Rohou, Nikolaus Grigorieff | J Struct Biol | 2015 | 26278980 | Yes |
| 1352 | 4037 | 2018.5 | 84.3 | 42.1 | A general framework for weighted gene co-expression network analysis. | Bin Zhang, Steve Horvath | Stat Appl Genet Mol Biol | 2005 | 16646834 | Yes |
| 1353 | 2018 | 2018.0 | 45.6 | 45.6 | The immunopathogenesis of sepsis. | Jonathan Cohen | Nature | 2002 | 12490963 | No |
| 1354 | 2016 | 2016.0 | 40.9 | 40.9 | CpG motifs in bacterial DNA and their immune effects. | Arthur M Krieg | Annu Rev Immunol | 2002 | 11861616 | No |
| 1355 | 8061 | 2015.2 | 324.5 | 81.1 | A simple technique for quantitation of low levels of DNA damage in individual cells. | N P Singh, M T McCoy, R R Tice, E L Schneider | Exp Cell Res | 1988 | 3345800 | Yes |
| 1356 | 2015 | 2015.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. | O Ouchterlony | Acta Pathol Microbiol Scand | 1949 | 18143039 | Yes |
| 1357 | 4029 | 2014.5 | 150.8 | 75.4 | Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. | Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon | Brain Connect | 2012 | 22642651 | Yes |
| 1358 | 2014 | 2014.0 | 88.3 | 88.3 | Sample size in qualitative research. | M Sandelowski | Res Nurs Health | 1995 | 7899572 | Yes |
| 1359 | 4024 | 2012.0 | 121.6 | 60.8 | A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. | J A Horne, O Ostberg | Int J Chronobiol | 1976 | 1027738 | Yes |
| 1360 | 2011 | 2011.0 | 69.6 | 69.6 | Validation of a decisional conflict scale. | A M O'Connor | Med Decis Making | 1995 | 7898294 | Yes |
| 1361 | 6033 | 2011.0 | 429.1 | 143.0 | Ferroptosis: mechanisms, biology and role in disease. | Xuejun Jiang, Brent R Stockwell, Marcus Conrad | Nat Rev Mol Cell Biol | 2021 | 33495651 | No |
| 1362 | 6032 | 2010.7 | 194.7 | 64.9 | SCANPY: large-scale single-cell gene expression data analysis. | F Alexander Wolf, Philipp Angerer, Fabian J Theis | Genome Biol | 2018 | 29409532 | Yes |
| 1363 | 4020 | 2010.0 | 89.7 | 44.9 | The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. | A J Ridley, A Hall | Cell | 1992 | 1643657 | Yes |
| 1364 | 2010 | 2010.0 | 36.9 | 36.9 | Signaling--2000 and beyond. | T Hunter | Cell | 2000 | 10647936 | No |
| 1365 | 2010 | 2010.0 | 51.2 | 51.2 | Growth of the plant cell wall. | Daniel J Cosgrove | Nat Rev Mol Cell Biol | 2005 | 16261190 | No |
| 1366 | 4019 | 2009.5 | 91.4 | 45.7 | Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. | J G Rheinwald, H Green | Cell | 1975 | 1052771 | Yes |
| 1367 | 4019 | 2009.5 | 99.2 | 49.6 | PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. | Alexander W Schuttelkopf, Daan M F Van Aalten | Acta Crystallogr D Biol Crystallogr | 2004 | 15272157 | Yes |
| 1368 | 2009 | 2009.0 | 46.2 | 46.2 | Exploring complex networks. | S H Strogatz | Nature | 2001 | 11258382 | No |
| 1369 | 2008 | 2008.0 | 44.0 | 44.0 | XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. | D E McRee | J Struct Biol | 1999 | 10222271 | Yes |
| 1370 | 2007 | 2007.0 | 44.6 | 44.6 | Structural design and molecular evolution of a cytokine receptor superfamily. | J F Bazan | Proc Natl Acad Sci U S A | 1990 | 2169613 | Yes |
| 1371 | 4013 | 2006.5 | 90.9 | 45.5 | Amino acid substitution matrices from protein blocks. | S Henikoff, J G Henikoff | Proc Natl Acad Sci U S A | 1992 | 1438297 | Yes |
| 1372 | 2005 | 2005.0 | 57.3 | 57.3 | The biology of interleukin-6. | T Kishimoto | Blood | 1989 | 2473791 | No |
| 1373 | 4010 | 2005.0 | 115.1 | 57.5 | Insulin-like growth factors and their binding proteins: biological actions. | J I Jones, D R Clemmons | Endocr Rev | 1995 | 7758431 | No |
| 1374 | 4007 | 2003.5 | 118.9 | 59.5 | How good are my data and what is the resolution? | Philip R Evans, Garib N Murshudov | Acta Crystallogr D Biol Crystallogr | 2013 | 23793146 | Yes |
| 1375 | 2002 | 2002.0 | 0.0 | 0.0 | Positional information and the spatial pattern of cellular differentiation. | L Wolpert | J Theor Biol | 1969 | 4390734 | Yes |
| 1376 | 2001 | 2001.0 | 117.2 | 117.2 | A network theory of mental disorders. | Denny Borsboom | World Psychiatry | 2017 | 28127906 | Yes |
| 1377 | 2000 | 2000.0 | 63.7 | 63.7 | Chlorophyll fluorescence: a probe of photosynthesis in vivo. | Neil R Baker | Annu Rev Plant Biol | 2008 | 18444897 | No |
| 1378 | 1998 | 1998.0 | 75.6 | 75.6 | Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. | D R Janero | Free Radic Biol Med | 1990 | 2079232 | No |
| 1379 | 1998 | 1998.0 | 41.4 | 41.4 | Mechanisms of intracellular protein transport. | J E Rothman | Nature | 1994 | 7969419 | No |
| 1380 | 1997 | 1997.0 | 43.8 | 43.8 | Thrombin signalling and protease-activated receptors. | S R Coughlin | Nature | 2000 | 11001069 | No |
| 1381 | 7986 | 1996.5 | 345.5 | 86.4 | An inventory for measuring clinical anxiety: psychometric properties. | A T Beck, N Epstein, G Brown, R A Steer | J Consult Clin Psychol | 1988 | 3204199 | Yes |
| 1382 | 1996 | 1996.0 | 0.0 | 0.0 | Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. | M Kunitz | J Gen Physiol | 1947 | 19873496 | Yes |
| 1383 | 1996 | 1996.0 | 110.9 | 110.9 | Information bias in health research: definition, pitfalls, and adjustment methods. | Alaa Althubaiti | J Multidiscip Healthc | 2016 | 27217764 | No |
| 1384 | 1995 | 1995.0 | 0.0 | 0.0 | The etiology of chondromalacia patellae. | R E Outerbridge | J Bone Joint Surg Br | 1961 | 14038135 | Yes |
| 1385 | 1994 | 1994.0 | 0.0 | 0.0 | The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. | U E Loening | Biochem J | 1967 | 5339944 | Yes |
| 1386 | 1994 | 1994.0 | 56.1 | 56.1 | Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. | J Folkman | N Engl J Med | 1995 | 7491141 | No |
| 1387 | 3985 | 1992.5 | 145.0 | 72.5 | Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. | M H Zweig, G Campbell | Clin Chem | 1993 | 8472349 | No |
| 1388 | 3985 | 1992.5 | 0.0 | 0.0 | Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. | W R Morrison, L M Smith | J Lipid Res | 1964 | 14221106 | Yes |
| 1389 | 1992 | 1992.0 | 59.6 | 59.6 | The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. | G P Chrousos | N Engl J Med | 1995 | 7715646 | No |
| 1390 | 3983 | 1991.5 | 92.7 | 46.4 | Shared principles in NF-kappaB signaling. | Matthew S Hayden, Sankar Ghosh | Cell | 2008 | 18267068 | No |
| 1391 | 5974 | 1991.3 | 346.3 | 115.4 | An interactive web-based dashboard to track COVID-19 in real time. | Ensheng Dong, Hongru Du, Lauren Gardner | Lancet Infect Dis | 2020 | 32087114 | Yes |
| 1392 | 1991 | 1991.0 | 75.7 | 75.7 | Falls in older people: epidemiology, risk factors and strategies for prevention. | Laurence Z Rubenstein | Age Ageing | 2006 | 16926202 | No |
| 1393 | 3981 | 1990.5 | 100.0 | 50.0 | The incidence of congenital heart disease. | Julien I E Hoffman, Samuel Kaplan | J Am Coll Cardiol | 2002 | 12084585 | No |
| 1394 | 3981 | 1990.5 | 106.3 | 53.1 | The endophenotype concept in psychiatry: etymology and strategic intentions. | Irving I Gottesman, Todd D Gould | Am J Psychiatry | 2003 | 12668349 | No |
| 1395 | 5971 | 1990.3 | 112.0 | 37.3 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. | Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky | Nat Immunol | 2003 | 12612578 | Yes |
| 1396 | 1990 | 1990.0 | 64.9 | 64.9 | Perceptual symbol systems. | L W Barsalou | Behav Brain Sci | 1999 | 11301525 | No |
| 1397 | 1990 | 1990.0 | 73.4 | 73.4 | Guided Search 2.0 A revised model of visual search. | J M Wolfe | Psychon Bull Rev | 1994 | 24203471 | Yes |
| 1398 | 5968 | 1989.3 | 157.0 | 52.3 | Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. | G S Hotamisligil, N S Shargill, B M Spiegelman | Science | 1993 | 7678183 | Yes |
| 1399 | 1989 | 1989.0 | 0.0 | 0.0 | High-speed scanning in human memory. | S Sternberg | Science | 1966 | 5939936 | Yes |
| 1400 | 1989 | 1989.0 | 42.7 | 42.7 | The expanding role of mitochondria in apoptosis. | X Wang | Genes Dev | 2001 | 11711427 | No |
| 1401 | 5966 | 1988.7 | 212.0 | 70.7 | Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. | L Excoffier, P E Smouse, J M Quattro | Genetics | 1992 | 1644282 | Yes |
| 1402 | 7946 | 1986.5 | 313.1 | 78.3 | QUAST: quality assessment tool for genome assemblies. | Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn Tesler | Bioinformatics | 2013 | 23422339 | Yes |
| 1403 | 1982 | 1982.0 | 0.0 | 0.0 | Influences of glucose loading and of injected insulin on hepatic glucose output. | R Steele | Ann N Y Acad Sci | 1959 | 13833973 | Yes |
| 1404 | 3962 | 1981.0 | 123.4 | 61.7 | Biofilms: survival mechanisms of clinically relevant microorganisms. | Rodney M Donlan, J William Costerton | Clin Microbiol Rev | 2002 | 11932229 | No |
| 1405 | 3961 | 1980.5 | 112.8 | 56.4 | Astrocytes: biology and pathology. | Michael V Sofroniew, Harry V Vinters | Acta Neuropathol | 2010 | 20012068 | No |
| 1406 | 1980 | 1980.0 | 68.5 | 68.5 | Physiological actions of taurine. | R J Huxtable | Physiol Rev | 1992 | 1731369 | No |
| 1407 | 1980 | 1980.0 | 51.1 | 51.1 | Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. | A Breslow | Ann Surg | 1970 | 5477666 | Yes |
| 1408 | 3956 | 1978.0 | 117.6 | 58.8 | Variations in the pattern of pubertal changes in boys. | W A Marshall, J M Tanner | Arch Dis Child | 1970 | 5440182 | Yes |
| 1409 | 3956 | 1978.0 | 85.9 | 43.0 | Monocyte and macrophage heterogeneity. | Siamon Gordon, Philip R Taylor | Nat Rev Immunol | 2005 | 16322748 | No |
| 1410 | 1977 | 1977.0 | 77.2 | 77.2 | The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. | E J Khantzian | Harv Rev Psychiatry | 1997 | 9385000 | No |
| 1411 | 1977 | 1977.0 | 0.0 | 0.0 | On estimating the relation between blood group and disease. | B Woolf | Ann Hum Genet | 1955 | 14388528 | Yes |
| 1412 | 3952 | 1976.0 | 103.7 | 51.9 | Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. | P J Barnes, M Karin | N Engl J Med | 1997 | 9091804 | No |
| 1413 | 1975 | 1975.0 | 46.1 | 46.1 | Fabrication of novel biomaterials through molecular self-assembly. | Shuguang Zhang | Nat Biotechnol | 2003 | 14520402 | No |
| 1414 | 1975 | 1975.0 | 45.7 | 45.7 | Integrating cell-signalling pathways with NF-kappaB and IKK function. | Neil D Perkins | Nat Rev Mol Cell Biol | 2007 | 17183360 | No |
| 1415 | 1974 | 1974.0 | 60.9 | 60.9 | Leptospirosis. | P N Levett | Clin Microbiol Rev | 2001 | 11292640 | No |
| 1416 | 1973 | 1973.0 | 74.2 | 74.2 | Recognition-by-components: a theory of human image understanding. | Irving Biederman | Psychol Rev | 1987 | 3575582 | Yes |
| 1417 | 3946 | 1973.0 | 127.9 | 64.0 | Oxygen toxicity, oxygen radicals, transition metals and disease. | B Halliwell, J M Gutteridge | Biochem J | 1984 | 6326753 | No |
| 1418 | 1973 | 1973.0 | 60.2 | 60.2 | Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. | A Dunaif | Endocr Rev | 1997 | 9408743 | No |
| 1419 | 5919 | 1973.0 | 192.8 | 64.3 | Validation of the Insomnia Severity Index as an outcome measure for insomnia research. | C H Bastien, A Vallieres, C M Morin | Sleep Med | 2001 | 11438246 | Yes |
| 1420 | 1970 | 1970.0 | 49.6 | 49.6 | The dawning era of polymer therapeutics. | Ruth Duncan | Nat Rev Drug Discov | 2003 | 12750738 | No |
| 1421 | 3939 | 1969.5 | 97.5 | 48.8 | Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. | A C Chang, S N Cohen | J Bacteriol | 1978 | 149110 | Yes |
| 1422 | 1969 | 1969.0 | 76.0 | 76.0 | Antibiotics in the aquatic environment--a review--part I. | Klaus Kummerer | Chemosphere | 2009 | 19185900 | No |
| 1423 | 1968 | 1968.0 | 56.4 | 56.4 | Multiple imputation of discrete and continuous data by fully conditional specification. | Stef Van Buuren | Stat Methods Med Res | 2007 | 17621469 | Yes |
| 1424 | 1967 | 1967.0 | 60.1 | 60.1 | Intracellular calcium homeostasis. | E Carafoli | Annu Rev Biochem | 1987 | 3304139 | No |
| 1425 | 1967 | 1967.0 | 51.4 | 51.4 | Cancer chemoprevention with dietary phytochemicals. | Young-Joon Surh | Nat Rev Cancer | 2003 | 14570043 | No |
| 1426 | 1967 | 1967.0 | 44.1 | 44.1 | Recognition of microorganisms and activation of the immune response. | Ruslan Medzhitov | Nature | 2007 | 17943118 | No |
| 1427 | 1966 | 1966.0 | 60.0 | 60.0 | Calbindin D-28k and parvalbumin in the rat nervous system. | M R Celio | Neuroscience | 1990 | 2199841 | Yes |
| 1428 | 3930 | 1965.0 | 81.2 | 40.6 | Identification of common molecular subsequences. | T F Smith, M S Waterman | J Mol Biol | 1981 | 7265238 | Yes |
| 1429 | 1963 | 1963.0 | 59.3 | 59.3 | Excitotoxic cell death. | D W Choi | J Neurobiol | 1992 | 1361523 | No |
| 1430 | 13741 | 1963.0 | 534.3 | 76.3 | Assessing the quality of reports of randomized clinical trials: is blinding necessary? | A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay | Control Clin Trials | 1996 | 8721797 | Yes |
| 1431 | 5887 | 1962.3 | 174.9 | 58.3 | Median-joining networks for inferring intraspecific phylogenies. | H J Bandelt, P Forster, A Rohl | Mol Biol Evol | 1999 | 10331250 | Yes |
| 1432 | 1962 | 1962.0 | 52.1 | 52.1 | The hydrogen bond in the solid state. | Thomas Steiner | Angew Chem Int Ed Engl | 2002 | 12491444 | Yes |
| 1433 | 1961 | 1961.0 | 49.5 | 49.5 | The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. | G S Manning | Q Rev Biophys | 1978 | 353876 | No |
| 1434 | 1959 | 1959.0 | 59.4 | 59.4 | Oxidative stress: oxidants and antioxidants. | H Sies | Exp Physiol | 1997 | 9129943 | No |
| 1435 | 1958 | 1958.0 | 89.5 | 89.5 | Adverse health effects of high-effort/low-reward conditions. | J Siegrist | J Occup Health Psychol | 1996 | 9547031 | No |
| 1436 | 1958 | 1958.0 | 58.1 | 58.1 | Porous scaffold design for tissue engineering. | Scott J Hollister | Nat Mater | 2005 | 16003400 | No |
| 1437 | 1958 | 1958.0 | 59.1 | 59.1 | Semiempirical hybrid density functional with perturbative second-order correlation. | Stefan Grimme | J Chem Phys | 2006 | 16438568 | Yes |
| 1438 | 3913 | 1956.5 | 127.3 | 63.6 | Neurocircuitry of addiction. | George F Koob, Nora D Volkow | Neuropsychopharmacology | 2010 | 19710631 | No |
| 1439 | 3911 | 1955.5 | 73.8 | 36.9 | Rho GTPases in cell biology. | Sandrine Etienne-Manneville, Alan Hall | Nature | 2002 | 12478284 | No |
| 1440 | 3910 | 1955.0 | 79.1 | 39.5 | Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. | M Karin, Y Ben-Neriah | Annu Rev Immunol | 2000 | 10837071 | No |
| 1441 | 1955 | 1955.0 | 47.8 | 47.8 | The blood-brain barrier: bottleneck in brain drug development. | William M Pardridge | NeuroRx | 2005 | 15717053 | No |
| 1442 | 3903 | 1951.5 | 94.5 | 47.2 | Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. | Felix Krueger, Simon R Andrews | Bioinformatics | 2011 | 21493656 | Yes |
| 1443 | 7804 | 1951.0 | 259.9 | 65.0 | The validity of the Hospital Anxiety and Depression Scale. An updated literature review. | Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann | J Psychosom Res | 2002 | 11832252 | No |
| 1444 | 1951 | 1951.0 | 42.7 | 42.7 | The hippo signaling pathway in development and cancer. | Duojia Pan | Dev Cell | 2010 | 20951342 | No |
| 1445 | 3901 | 1950.5 | 118.0 | 59.0 | Bronchopulmonary dysplasia. | A H Jobe, E Bancalari | Am J Respir Crit Care Med | 2001 | 11401896 | No |
| 1446 | 1950 | 1950.0 | 77.5 | 77.5 | Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. | A Fleckenstein | Annu Rev Pharmacol Toxicol | 1977 | 326161 | No |
| 1447 | 1950 | 1950.0 | 44.0 | 44.0 | Signal sequences. The limits of variation. | G Von Heijne | J Mol Biol | 1985 | 4032478 | Yes |
| 1448 | 1949 | 1949.0 | 43.6 | 43.6 | Biology of natural killer cells. | G Trinchieri | Adv Immunol | 1989 | 2683611 | No |
| 1449 | 3898 | 1949.0 | 95.4 | 47.7 | Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. | I W McLean, P K Nakane | J Histochem Cytochem | 1974 | 4374474 | Yes |
| 1450 | 1949 | 1949.0 | 72.7 | 72.7 | Transcriptional architecture of the mammalian circadian clock. | Joseph S Takahashi | Nat Rev Genet | 2017 | 27990019 | No |
| 1451 | 3898 | 1949.0 | 402.6 | 201.3 | Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. | Luke A McGuinness, Julian P T Higgins | Res Synth Methods | 2021 | 32336025 | Yes |
| 1452 | 1946 | 1946.0 | 34.9 | 34.9 | The regulation of E2F by pRB-family proteins. | N Dyson | Genes Dev | 1998 | 9694791 | No |
| 1453 | 1946 | 1946.0 | 37.3 | 37.3 | Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. | M G Gustafsson | J Microsc | 2000 | 10810003 | Yes |
| 1454 | 3892 | 1946.0 | 130.2 | 65.1 | miRBase: annotating high confidence microRNAs using deep sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2014 | 24275495 | Yes |
| 1455 | 1945 | 1945.0 | 46.1 | 46.1 | Cellular mechanisms of insulin resistance. | G I Shulman | J Clin Invest | 2000 | 10903330 | No |
| 1456 | 3889 | 1944.5 | 148.5 | 74.2 | Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. | M Mihara, M Uchiyama | Anal Biochem | 1978 | 655387 | Yes |
| 1457 | 1944 | 1944.0 | 48.4 | 48.4 | Evolutionary relationship of DNA sequences in finite populations. | F Tajima | Genetics | 1983 | 6628982 | Yes |
| 1458 | 5832 | 1944.0 | 140.7 | 46.9 | Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. | Michael W Pfaffl, Graham W Horgan, Leo Dempfle | Nucleic Acids Res | 2002 | 11972351 | Yes |
| 1459 | 1944 | 1944.0 | 0.0 | 0.0 | The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. | S V Boyden | J Exp Med | 1951 | 14803635 | Yes |
| 1460 | 5827 | 1942.3 | 124.2 | 41.4 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel, J D Roberts, R A Zakour | Methods Enzymol | 1987 | 3323813 | Yes |
| 1461 | 1941 | 1941.0 | 55.9 | 55.9 | The many roles for fluorine in medicinal chemistry. | William K Hagmann | J Med Chem | 2008 | 18570365 | Yes |
| 1462 | 5821 | 1940.3 | 179.9 | 60.0 | Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. | P A Wolf, R D Abbott, W B Kannel | Stroke | 1991 | 1866765 | Yes |
| 1463 | 1940 | 1940.0 | 84.9 | 84.9 | Responses to depression and their effects on the duration of depressive episodes. | S Nolen-Hoeksema | J Abnorm Psychol | 1991 | 1757671 | No |
| 1464 | 5819 | 1939.7 | 127.2 | 42.4 | A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. | J H Zhang, T D Chung, K R Oldenburg | J Biomol Screen | 1999 | 10838414 | Yes |
| 1465 | 1939 | 1939.0 | 48.4 | 48.4 | Thioredoxin. | A Holmgren | Annu Rev Biochem | 1985 | 3896121 | No |
| 1466 | 1939 | 1939.0 | 59.1 | 59.1 | Intermediate filaments as mechanical integrators of cellular space. | E Lazarides | Nature | 1980 | 7188712 | Yes |
| 1467 | 1936 | 1936.0 | 48.5 | 48.5 | Tricine-SDS-PAGE. | Hermann Schagger | Nat Protoc | 2006 | 17406207 | Yes |
| 1468 | 1935 | 1935.0 | 0.0 | 0.0 | Evolutionary rate at the molecular level. | M Kimura | Nature | 1968 | 5637732 | Yes |
| 1469 | 3869 | 1934.5 | 96.6 | 48.3 | Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. | Christian Haass, Dennis J Selkoe | Nat Rev Mol Cell Biol | 2007 | 17245412 | No |
| 1470 | 3868 | 1934.0 | 231.0 | 115.5 | An Overview of Heart Rate Variability Metrics and Norms. | Fred Shaffer, J P Ginsberg | Front Public Health | 2017 | 29034226 | No |
| 1471 | 1934 | 1934.0 | 218.7 | 218.7 | Epidemiology of chronic kidney disease: an update 2022. | Csaba P Kovesdy | Kidney Int Suppl (2011) | 2022 | 35529086 | No |
| 1472 | 3866 | 1933.0 | 132.4 | 66.2 | Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. | G Di Chiara, A Imperato | Proc Natl Acad Sci U S A | 1988 | 2899326 | Yes |
| 1473 | 1933 | 1933.0 | 54.8 | 54.8 | The importance of the ratio of omega-6/omega-3 essential fatty acids. | A P Simopoulos | Biomed Pharmacother | 2002 | 12442909 | No |
| 1474 | 3865 | 1932.5 | 106.7 | 53.4 | Inositol phosphates and cell signalling. | M J Berridge, R F Irvine | Nature | 1989 | 2550825 | No |
| 1475 | 3865 | 1932.5 | 151.1 | 75.5 | Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. | M M Bradley, P J Lang | J Behav Ther Exp Psychiatry | 1994 | 7962581 | Yes |
| 1476 | 9661 | 1932.2 | 362.1 | 72.4 | UCHIME improves sensitivity and speed of chimera detection. | Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight | Bioinformatics | 2011 | 21700674 | Yes |
| 1477 | 1932 | 1932.0 | 48.7 | 48.7 | Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. | J P Chamberlain | Anal Biochem | 1979 | 543547 | Yes |
| 1478 | 1932 | 1932.0 | 51.7 | 51.7 | DNA topoisomerase poisons as antitumor drugs. | L F Liu | Annu Rev Biochem | 1989 | 2549853 | No |
| 1479 | 1932 | 1932.0 | 41.2 | 41.2 | Oxidative stress shortens telomeres. | Thomas Von Zglinicki | Trends Biochem Sci | 2002 | 12114022 | Yes |
| 1480 | 1932 | 1932.0 | 65.0 | 65.0 | A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. | Ozcan Erel | Clin Biochem | 2004 | 15003729 | Yes |
| 1481 | 7714 | 1928.5 | 195.5 | 48.9 | p53 mutations in human cancers. | M Hollstein, D Sidransky, B Vogelstein, C C Harris | Science | 1991 | 1905840 | No |
| 1482 | 1927 | 1927.0 | 53.6 | 53.6 | Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. | H LeVine | Protein Sci | 1993 | 8453378 | Yes |
| 1483 | 3846 | 1923.0 | 0.0 | 0.0 | Acetylornithinase of Escherichia coli: partial purification and some properties. | H J Vogel, D M Bonner | J Biol Chem | 1956 | 13278318 | Yes |
| 1484 | 9613 | 1922.6 | 226.8 | 45.4 | Stages of embryonic development of the zebrafish. | C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling | Dev Dyn | 1995 | 8589427 | Yes |
| 1485 | 1922 | 1922.0 | 66.7 | 66.7 | Constructions of masculinity and their influence on men's well-being: a theory of gender and health. | W H Courtenay | Soc Sci Med | 2000 | 10741575 | No |
| 1486 | 1920 | 1920.0 | 67.8 | 67.8 | Ordinary magic. Resilience processes in development. | A S Masten | Am Psychol | 2001 | 11315249 | Yes |
| 1487 | 1920 | 1920.0 | 63.3 | 63.3 | The global impact of pre-eclampsia and eclampsia. | Lelia Duley | Semin Perinatol | 2009 | 19464502 | No |
| 1488 | 11510 | 1918.3 | 319.6 | 53.3 | A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. | Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier | Science | 2012 | 22745249 | Yes |
| 1489 | 7673 | 1918.2 | 255.3 | 63.8 | cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination. | Ali Punjani, John L Rubinstein, David J Fleet, Marcus A Brubaker | Nat Methods | 2017 | 28165473 | Yes |
| 1490 | 1918 | 1918.0 | 67.3 | 67.3 | The stress response in fish. | S E Wendelaar Bonga | Physiol Rev | 1997 | 9234959 | No |
| 1491 | 1917 | 1917.0 | 46.2 | 46.2 | The failing heart--an engine out of fuel. | Stefan Neubauer | N Engl J Med | 2007 | 17360992 | No |
| 1492 | 1915 | 1915.0 | 36.2 | 36.2 | Network motifs: theory and experimental approaches. | Uri Alon | Nat Rev Genet | 2007 | 17510665 | No |
| 1493 | 1914 | 1914.0 | 53.2 | 53.2 | A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. | P J Goodford | J Med Chem | 1985 | 3892003 | Yes |
| 1494 | 1913 | 1913.0 | 48.0 | 48.0 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1985 | 2992360 | No |
| 1495 | 1913 | 1913.0 | 29.1 | 29.1 | Chromatin structure: a repeating unit of histones and DNA. | R D Kornberg | Science | 1974 | 4825889 | Yes |
| 1496 | 1913 | 1913.0 | 66.8 | 66.8 | The Resonating Valence Bond State in La2CuO4 and Superconductivity. | P W Anderson | Science | 1987 | 17818979 | Yes |
| 1497 | 1913 | 1913.0 | 89.8 | 89.8 | Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. | Kevin A Hallgren | Tutor Quant Methods Psychol | 2012 | 22833776 | Yes |
| 1498 | 1912 | 1912.0 | 53.4 | 53.4 | In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. | T R Chen | Exp Cell Res | 1977 | 65285 | Yes |
| 1499 | 1912 | 1912.0 | 48.6 | 48.6 | Marine viruses--major players in the global ecosystem. | Curtis A Suttle | Nat Rev Microbiol | 2007 | 17853907 | No |
| 1500 | 3823 | 1911.5 | 88.4 | 44.2 | Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. | T Miyashita, J C Reed | Cell | 1995 | 7834749 | Yes |
| 1501 | 3823 | 1911.5 | 139.4 | 69.7 | Cisplatin in cancer therapy: molecular mechanisms of action. | Shaloam Dasari, Paul Bernard Tchounwou | Eur J Pharmacol | 2014 | 25058905 | No |
| 1502 | 1911 | 1911.0 | 0.0 | 0.0 | Note on the sampling error of the difference between correlated proportions or percentages. | Q McNEMAR | Psychometrika | 1947 | 20254758 | Yes |
| 1503 | 1911 | 1911.0 | 85.7 | 85.7 | Mechanisms linking social ties and support to physical and mental health. | Peggy A Thoits | J Health Soc Behav | 2011 | 21673143 | No |
| 1504 | 5732 | 1910.7 | 260.2 | 86.7 | Research diagnostic criteria: rationale and reliability. | R L Spitzer, J Endicott, E Robins | Arch Gen Psychiatry | 1978 | 655775 | Yes |
| 1505 | 3818 | 1909.0 | 201.3 | 100.7 | Interrater reliability of a modified Ashworth scale of muscle spasticity. | R W Bohannon, M B Smith | Phys Ther | 1987 | 3809245 | Yes |
| 1506 | 3817 | 1908.5 | 109.9 | 55.0 | Alzheimer's disease. | Henry W Querfurth, Frank M LaFerla | N Engl J Med | 2010 | 20107219 | No |
| 1507 | 5722 | 1907.3 | 159.4 | 53.1 | A neural substrate of prediction and reward. | W Schultz, P Dayan, P R Montague | Science | 1997 | 9054347 | No |
| 1508 | 1907 | 1907.0 | 42.4 | 42.4 | The mitogen-activated protein kinase signal transduction pathway. | R J Davis | J Biol Chem | 1993 | 8325833 | No |
| 1509 | 1905 | 1905.0 | 73.0 | 73.0 | A simple fluorometric assay for lipoperoxide in blood plasma. | K Yagi | Biochem Med | 1976 | 962904 | Yes |
| 1510 | 3810 | 1905.0 | 93.8 | 46.9 | The future of genetic studies of complex human diseases. | N Risch, K Merikangas | Science | 1996 | 8801636 | Yes |
| 1511 | 1904 | 1904.0 | 47.2 | 47.2 | Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. | Z Yang | J Mol Evol | 1994 | 7932792 | Yes |
| 1512 | 1904 | 1904.0 | 42.9 | 42.9 | The NCI60 human tumour cell line anticancer drug screen. | Robert H Shoemaker | Nat Rev Cancer | 2006 | 16990858 | No |
| 1513 | 1903 | 1903.0 | 40.1 | 40.1 | Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. | R J Kaufman | Genes Dev | 1999 | 10346810 | No |
| 1514 | 1902 | 1902.0 | 53.4 | 53.4 | Oxidative stress and neurodegeneration: where are we now? | Barry Halliwell | J Neurochem | 2006 | 16805774 | No |
| 1515 | 1902 | 1902.0 | 47.2 | 47.2 | Five rules for the evolution of cooperation. | Martin A Nowak | Science | 2006 | 17158317 | No |
| 1516 | 1901 | 1901.0 | 49.5 | 49.5 | Adipose tissue, adipokines, and inflammation. | Giamila Fantuzzi | J Allergy Clin Immunol | 2005 | 15867843 | No |
| 1517 | 1900 | 1900.0 | 0.0 | 0.0 | The oxidation of ribonuclease with performic acid. | C H Hirs | J Biol Chem | 1956 | 13319283 | Yes |
| 1518 | 5697 | 1899.0 | 139.0 | 46.3 | A new statistical method for haplotype reconstruction from population data. | M Stephens, N J Smith, P Donnelly | Am J Hum Genet | 2001 | 11254454 | Yes |
| 1519 | 3797 | 1898.5 | 86.2 | 43.1 | Insulin signalling and the regulation of glucose and lipid metabolism. | A R Saltiel, C R Kahn | Nature | 2001 | 11742412 | Yes |
| 1520 | 13288 | 1898.3 | 461.3 | 65.9 | The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. | Erik Von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gotzsche, Jan P Vandenbroucke, | J Clin Epidemiol | 2008 | 18313558 | Yes |
| 1521 | 3796 | 1898.0 | 116.7 | 58.4 | The future of immune checkpoint therapy. | Padmanee Sharma, James P Allison | Science | 2015 | 25838373 | No |
| 1522 | 7589 | 1897.2 | 257.0 | 64.2 | Reporting results of cancer treatment. | A B Miller, B Hoogstraten, M Staquet, A Winkler | Cancer | 1981 | 7459811 | Yes |
| 1523 | 1897 | 1897.0 | 90.1 | 90.1 | Determinants of low birth weight: methodological assessment and meta-analysis. | M S Kramer | Bull World Health Organ | 1987 | 3322602 | No |
| 1524 | 3791 | 1895.5 | 82.8 | 41.4 | Cell death: critical control points. | Nika N Danial, Stanley J Korsmeyer | Cell | 2004 | 14744432 | No |
| 1525 | 1895 | 1895.0 | 36.0 | 36.0 | Cellular roles of DNA topoisomerases: a molecular perspective. | James C Wang | Nat Rev Mol Cell Biol | 2002 | 12042765 | No |
| 1526 | 1894 | 1894.0 | 65.9 | 65.9 | An overview of brominated flame retardants in the environment. | Cynthia A De Wit | Chemosphere | 2002 | 11999784 | No |
| 1527 | 1894 | 1894.0 | 52.5 | 52.5 | Understanding biofilm resistance to antibacterial agents. | David Davies | Nat Rev Drug Discov | 2003 | 12563302 | No |
| 1528 | 1894 | 1894.0 | 37.1 | 37.1 | Cancer and the chemokine network. | Fran Balkwill | Nat Rev Cancer | 2004 | 15229479 | No |
| 1529 | 3786 | 1893.0 | 148.7 | 74.3 | The mini-mental state examination: a comprehensive review. | T N Tombaugh, N J McIntyre | J Am Geriatr Soc | 1992 | 1512391 | No |
| 1530 | 1893 | 1893.0 | 61.4 | 61.4 | Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. | Joseph J Volpe | Lancet Neurol | 2009 | 19081519 | No |
| 1531 | 3784 | 1892.0 | 93.3 | 46.6 | An efficient mRNA-dependent translation system from reticulocyte lysates. | H R Pelham, R J Jackson | Eur J Biochem | 1976 | 823012 | Yes |
| 1532 | 1892 | 1892.0 | 43.7 | 43.7 | Two pathogenetic types of endometrial carcinoma. | J V Bokhman | Gynecol Oncol | 1983 | 6822361 | Yes |
| 1533 | 1892 | 1892.0 | 48.1 | 48.1 | The mitochondrial permeability transition pore and its role in cell death. | M Crompton | Biochem J | 1999 | 10393078 | No |
| 1534 | 3782 | 1891.0 | 80.3 | 40.1 | Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. | C D Nobes, A Hall | Cell | 1995 | 7536630 | Yes |
| 1535 | 1891 | 1891.0 | 39.1 | 39.1 | Molecular regulation of vessel maturation. | Rakesh K Jain | Nat Med | 2003 | 12778167 | No |
| 1536 | 1890 | 1890.0 | 77.5 | 77.5 | Brain dopamine receptors. | P Seeman | Pharmacol Rev | 1980 | 6117090 | No |
| 1537 | 1890 | 1890.0 | 48.9 | 48.9 | Cellular basis of working memory. | P S Goldman-Rakic | Neuron | 1995 | 7695894 | No |
| 1538 | 1890 | 1890.0 | 56.4 | 56.4 | Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. | James J P Stewart | J Mol Model | 2007 | 17828561 | Yes |
| 1539 | 3778 | 1889.0 | 81.1 | 40.5 | Why do cancers have high aerobic glycolysis? | Robert A Gatenby, Robert J Gillies | Nat Rev Cancer | 2004 | 15516961 | No |
| 1540 | 3777 | 1888.5 | 91.2 | 45.6 | Origins and Mechanisms of miRNAs and siRNAs. | Richard W Carthew, Erik J Sontheimer | Cell | 2009 | 19239886 | No |
| 1541 | 1888 | 1888.0 | 48.5 | 48.5 | Complete nucleotide sequence of the Escherichia coli plasmid pBR322. | J G Sutcliffe | Cold Spring Harb Symp Quant Biol | 1979 | 383387 | Yes |
| 1542 | 1888 | 1888.0 | 73.3 | 73.3 | Multimodal approach to control postoperative pathophysiology and rehabilitation. | H Kehlet | Br J Anaesth | 1997 | 9175983 | No |
| 1543 | 3774 | 1887.0 | 116.5 | 58.2 | Oxidative stress and diabetic complications. | Ferdinando Giacco, Michael Brownlee | Circ Res | 2010 | 21030723 | No |
| 1544 | 1886 | 1886.0 | 40.6 | 40.6 | Points of control in inflammation. | Carl Nathan | Nature | 2002 | 12490957 | No |
| 1545 | 1886 | 1886.0 | 50.5 | 50.5 | Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. | Shitij Kapur | Am J Psychiatry | 2003 | 12505794 | No |
| 1546 | 1886 | 1886.0 | 38.7 | 38.7 | MicroRNA biogenesis: coordinated cropping and dicing. | V Narry Kim | Nat Rev Mol Cell Biol | 2005 | 15852042 | No |
| 1547 | 1885 | 1885.0 | 61.8 | 61.8 | Emotion regulation: affective, cognitive, and social consequences. | James J Gross | Psychophysiology | 2002 | 12212647 | No |
| 1548 | 3770 | 1885.0 | 101.8 | 50.9 | A perspective on cancer cell metastasis. | Christine L Chaffer, Robert A Weinberg | Science | 2011 | 21436443 | No |
| 1549 | 9425 | 1885.0 | 402.8 | 80.6 | BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs. | Felipe A Simao, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M Zdobnov | Bioinformatics | 2015 | 26059717 | Yes |
| 1550 | 1884 | 1884.0 | 78.0 | 78.0 | Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. | H U Wittchen | J Psychiatr Res | 1994 | 8064641 | No |
| 1551 | 1883 | 1883.0 | 44.0 | 44.0 | The Unified Medical Language System (UMLS): integrating biomedical terminology. | Olivier Bodenreider | Nucleic Acids Res | 2004 | 14681409 | Yes |
| 1552 | 3766 | 1883.0 | 155.1 | 77.5 | Interpreting findings from Mendelian randomization using the MR-Egger method. | Stephen Burgess, Simon G Thompson | Eur J Epidemiol | 2017 | 28527048 | Yes |
| 1553 | 1882 | 1882.0 | 41.6 | 41.6 | Excitatory actions of gaba during development: the nature of the nurture. | Yehezkel Ben-Ari | Nat Rev Neurosci | 2002 | 12209121 | No |
| 1554 | 7523 | 1880.8 | 188.6 | 47.1 | Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. | A Shevchenko, M Wilm, O Vorm, M Mann | Anal Chem | 1996 | 8779443 | Yes |
| 1555 | 3761 | 1880.5 | 128.6 | 64.3 | Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. | R A DeFronzo, E Ferrannini | Diabetes Care | 1991 | 2044434 | No |
| 1556 | 5640 | 1880.0 | 146.0 | 48.7 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. | Z N Oltvai, C L Milliman, S J Korsmeyer | Cell | 1993 | 8358790 | Yes |
| 1557 | 3759 | 1879.5 | 149.3 | 74.7 | MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. | Rajesha Rupaimoole, Frank J Slack | Nat Rev Drug Discov | 2017 | 28209991 | No |
| 1558 | 3758 | 1879.0 | 0.0 | 0.0 | Receptive fields and functional architecture of monkey striate cortex. | D H Hubel, T N Wiesel | J Physiol | 1968 | 4966457 | Yes |
| 1559 | 1879 | 1879.0 | 67.0 | 67.0 | A Protection Motivation Theory of Fear Appeals and Attitude Change1. | Ronald W Rogers | J Psychol | 1975 | 28136248 | Yes |
| 1560 | 7514 | 1878.5 | 229.6 | 57.4 | Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. | B Biswal, F Z Yetkin, V M Haughton, J S Hyde | Magn Reson Med | 1995 | 8524021 | Yes |
| 1561 | 3757 | 1878.5 | 111.3 | 55.6 | The mirror-neuron system. | Giacomo Rizzolatti, Laila Craighero | Annu Rev Neurosci | 2004 | 15217330 | No |
| 1562 | 1876 | 1876.0 | 79.2 | 79.2 | Why patients use alternative medicine: results of a national study. | J A Astin | JAMA | 1998 | 9605899 | Yes |
| 1563 | 1876 | 1876.0 | 38.9 | 38.9 | The effect of infections on susceptibility to autoimmune and allergic diseases. | Jean-Francois Bach | N Engl J Med | 2002 | 12239261 | No |
| 1564 | 3750 | 1875.0 | 128.5 | 64.2 | Separate visual pathways for perception and action. | M A Goodale, A D Milner | Trends Neurosci | 1992 | 1374953 | No |
| 1565 | 1875 | 1875.0 | 94.1 | 94.1 | Derivation and validation of a short-form oral health impact profile. | G D Slade | Community Dent Oral Epidemiol | 1997 | 9332805 | Yes |
| 1566 | 3748 | 1874.0 | 150.6 | 75.3 | Assays of glutathione peroxidase. | L Flohe, W A Gunzler | Methods Enzymol | 1984 | 6727659 | Yes |
| 1567 | 1873 | 1873.0 | 60.6 | 60.6 | Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. | M Zasloff | Proc Natl Acad Sci U S A | 1987 | 3299384 | Yes |
| 1568 | 7491 | 1872.8 | 277.6 | 69.4 | FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. | Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs Schoffelen | Comput Intell Neurosci | 2011 | 21253357 | Yes |
| 1569 | 3745 | 1872.5 | 111.0 | 55.5 | Neoantigens in cancer immunotherapy. | Ton N Schumacher, Robert D Schreiber | Science | 2015 | 25838375 | No |
| 1570 | 1872 | 1872.0 | 71.0 | 71.0 | Simple proton spectroscopic imaging. | W T Dixon | Radiology | 1984 | 6089263 | Yes |
| 1571 | 9358 | 1871.6 | 371.5 | 74.3 | Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption--II. | J B Saunders, O G Aasland, T F Babor, J R De La Fuente, M Grant | Addiction | 1993 | 8329970 | Yes |
| 1572 | 1871 | 1871.0 | 39.3 | 39.3 | Protein homology detection by HMM-HMM comparison. | Johannes Soding | Bioinformatics | 2005 | 15531603 | Yes |
| 1573 | 1870 | 1870.0 | 48.4 | 48.4 | Clinical application of C-reactive protein for cardiovascular disease detection and prevention. | Paul M Ridker | Circulation | 2003 | 12551853 | No |
| 1574 | 1869 | 1869.0 | 39.4 | 39.4 | A cell culture model for T lymphocyte clonal anergy. | R H Schwartz | Science | 1990 | 2113314 | Yes |
| 1575 | 1869 | 1869.0 | 56.8 | 56.8 | A classification of hand preference by association analysis. | M Annett | Br J Psychol | 1970 | 5457503 | Yes |
| 1576 | 1868 | 1868.0 | 61.8 | 61.8 | Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. | F Rousset | Genetics | 1997 | 9093870 | Yes |
| 1577 | 1868 | 1868.0 | 52.9 | 52.9 | Hepatitis B virus infection. | W M Lee | N Engl J Med | 1997 | 9392700 | No |
| 1578 | 5602 | 1867.3 | 111.4 | 37.1 | Surfing the p53 network. | B Vogelstein, D Lane, A J Levine | Nature | 2000 | 11099028 | No |
| 1579 | 5600 | 1866.7 | 150.6 | 50.2 | The rapid generation of mutation data matrices from protein sequences. | D T Jones, W R Taylor, J M Thornton | Comput Appl Biosci | 1992 | 1633570 | Yes |
| 1580 | 1866 | 1866.0 | 0.0 | 0.0 | A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. | D A Robinson | IEEE Trans Biomed Eng | 1963 | 14121113 | Yes |
| 1581 | 1865 | 1865.0 | 0.0 | 0.0 | A new readability yardstick. | R Flesch | J Appl Psychol | 1948 | 18867058 | Yes |
| 1582 | 14915 | 1864.4 | 426.5 | 53.3 | Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. | R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich | Science | 1988 | 2448875 | Yes |
| 1583 | 9321 | 1864.2 | 0.0 | 0.0 | Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. | S Katz, A B Ford, R W Moskowitz, B A Jackson, M W Jaffe | JAMA | 1963 | 14044222 | Yes |
| 1584 | 3725 | 1862.5 | 120.4 | 60.2 | Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. | F Denizot, R Lang | J Immunol Methods | 1986 | 3486233 | Yes |
| 1585 | 3725 | 1862.5 | 88.1 | 44.0 | The Fas death factor. | S Nagata, P Golstein | Science | 1995 | 7533326 | No |
| 1586 | 3725 | 1862.5 | 126.9 | 63.5 | Role of the microbiota in immunity and inflammation. | Yasmine Belkaid, Timothy W Hand | Cell | 2014 | 24679531 | No |
| 1587 | 1862 | 1862.0 | 36.6 | 36.6 | Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. | Judith Campisi | Cell | 2005 | 15734683 | No |
| 1588 | 1861 | 1861.0 | 0.0 | 0.0 | The recurrence of intracranial meningiomas after surgical treatment. | D Simpson | J Neurol Neurosurg Psychiatry | 1957 | 13406590 | Yes |
| 1589 | 9304 | 1860.8 | 269.1 | 53.8 | Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. | Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King | Diabetes Care | 2004 | 15111519 | Yes |
| 1590 | 20468 | 1860.7 | 543.7 | 49.4 | The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. | Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo | Genome Res | 2010 | 20644199 | Yes |
| 1591 | 5580 | 1860.0 | 135.4 | 45.1 | Inflammation and atherosclerosis. | Peter Libby, Paul M Ridker, Attilio Maseri | Circulation | 2002 | 11877368 | No |
| 1592 | 1860 | 1860.0 | 45.6 | 45.6 | PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. | Michael F Thomashow | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012220 | Yes |
| 1593 | 9298 | 1859.6 | 247.4 | 49.5 | Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. | Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-Yuan Hsu | N Engl J Med | 2004 | 15385656 | Yes |
| 1594 | 1858 | 1858.0 | 50.8 | 50.8 | Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. | D M Neville | J Biol Chem | 1971 | 5127429 | Yes |
| 1595 | 1858 | 1858.0 | 46.5 | 46.5 | Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. | D Lavanchy | J Viral Hepat | 2004 | 14996343 | No |
| 1596 | 3712 | 1856.0 | 99.8 | 49.9 | Multiple sclerosis. | Alastair Compston, Alasdair Coles | Lancet | 2008 | 18970977 | Yes |
| 1597 | 3711 | 1855.5 | 82.0 | 41.0 | Raster3D: photorealistic molecular graphics. | E A Merritt, D J Bacon | Methods Enzymol | 1997 | 18488322 | Yes |
| 1598 | 1855 | 1855.0 | 45.2 | 45.2 | A revolution in optical manipulation. | David G Grier | Nature | 2003 | 12917694 | No |
| 1599 | 1854 | 1854.0 | 42.8 | 42.8 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1996 | 8811192 | No |
| 1600 | 7415 | 1853.8 | 261.6 | 65.4 | Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. | D J Sahn, A DeMaria, J Kisslo, A Weyman | Circulation | 1978 | 709763 | Yes |
| 1601 | 1853 | 1853.0 | 48.0 | 48.0 | External validity of randomised controlled trials: "to whom do the results of this trial apply?". | Peter M Rothwell | Lancet | 2005 | 15639683 | Yes |
| 1602 | 3702 | 1851.0 | 116.2 | 58.1 | An information-maximization approach to blind separation and blind deconvolution. | A J Bell, T J Sejnowski | Neural Comput | 1995 | 7584893 | Yes |
| 1603 | 1851 | 1851.0 | 53.8 | 53.8 | Chlorpromazine equivalent doses for the newer atypical antipsychotics. | Scott W Woods | J Clin Psychiatry | 2003 | 12823080 | No |
| 1604 | 1851 | 1851.0 | 41.2 | 41.2 | Perceptions of epigenetics. | Adrian Bird | Nature | 2007 | 17522671 | Yes |
| 1605 | 7400 | 1850.0 | 307.7 | 76.9 | 16S ribosomal DNA amplification for phylogenetic study. | W G Weisburg, S M Barns, D A Pelletier, D J Lane | J Bacteriol | 1991 | 1987160 | Yes |
| 1606 | 1850 | 1850.0 | 63.4 | 63.4 | Large-scale neurocognitive networks and distributed processing for attention, language, and memory. | M M Mesulam | Ann Neurol | 1990 | 2260847 | No |
| 1607 | 1850 | 1850.0 | 54.0 | 54.0 | Task switching. | Stephen Monsell | Trends Cogn Sci | 2003 | 12639695 | Yes |
| 1608 | 1850 | 1850.0 | 41.6 | 41.6 | Hematopoietic stem-cell transplantation. | Edward A Copelan | N Engl J Med | 2006 | 16641398 | No |
| 1609 | 1849 | 1849.0 | 87.2 | 87.2 | ROS Are Good. | Ron Mittler | Trends Plant Sci | 2017 | 27666517 | No |
| 1610 | 1847 | 1847.0 | 99.8 | 99.8 | Epidemiology of Prostate Cancer. | Prashanth Rawla | World J Oncol | 2019 | 31068988 | No |
| 1611 | 3692 | 1846.0 | 141.6 | 70.8 | The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. | A J Stunkard, S Messick | J Psychosom Res | 1985 | 3981480 | Yes |
| 1612 | 1846 | 1846.0 | 0.0 | 0.0 | Protein denaturation. | C Tanford | Adv Protein Chem | 1968 | 4882248 | No |
| 1613 | 7384 | 1846.0 | 150.5 | 37.6 | Stem cells, cancer, and cancer stem cells. | T Reya, S J Morrison, M F Clarke, I L Weissman | Nature | 2001 | 11689955 | No |
| 1614 | 3692 | 1846.0 | 0.0 | 0.0 | Convergent and discriminant validation by the multitrait-multimethod matrix. | D T Campbell, D W Fiske | Psychol Bull | 1959 | 13634291 | Yes |
| 1615 | 3690 | 1845.0 | 81.7 | 40.9 | Fibroblasts in cancer. | Raghu Kalluri, Michael Zeisberg | Nat Rev Cancer | 2006 | 16572188 | No |
| 1616 | 3689 | 1844.5 | 161.4 | 80.7 | Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2016 | 27095192 | Yes |
| 1617 | 1844 | 1844.0 | 0.0 | 0.0 | The influence of some cations on an adenosine triphosphatase from peripheral nerves. | J C Skou | Biochim Biophys Acta | 1957 | 13412736 | Yes |
| 1618 | 3687 | 1843.5 | 0.0 | 0.0 | Immunoassay of insulin with insulin-antibody precipitate. | C N Hales, P J Randle | Biochem J | 1963 | 13952078 | Yes |
| 1619 | 3687 | 1843.5 | 119.1 | 59.5 | Van der Waals heterostructures. | A K Geim, I V Grigorieva | Nature | 2013 | 23887427 | Yes |
| 1620 | 1843 | 1843.0 | 64.2 | 64.2 | The crisis in antibiotic resistance. | H C Neu | Science | 1992 | 1509257 | No |
| 1621 | 1843 | 1843.0 | 69.3 | 69.3 | Nonalcoholic fatty liver disease: a systematic review. | Mary E Rinella | JAMA | 2015 | 26057287 | Yes |
| 1622 | 3685 | 1842.5 | 86.2 | 43.1 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. | K D McCarthy, J De Vellis | J Cell Biol | 1980 | 6248568 | Yes |
| 1623 | 1842 | 1842.0 | 81.3 | 81.3 | When to use the Bonferroni correction. | Richard A Armstrong | Ophthalmic Physiol Opt | 2014 | 24697967 | No |
| 1624 | 1841 | 1841.0 | 40.1 | 40.1 | Trastuzumab--mechanism of action and use in clinical practice. | Clifford A Hudis | N Engl J Med | 2007 | 17611206 | No |
| 1625 | 1840 | 1840.0 | 46.3 | 46.3 | Type III protein secretion systems in bacterial pathogens of animals and plants. | C J Hueck | Microbiol Mol Biol Rev | 1998 | 9618447 | No |
| 1626 | 1840 | 1840.0 | 74.8 | 74.8 | Working memory: theories, models, and controversies. | Alan Baddeley | Annu Rev Psychol | 2012 | 21961947 | No |
| 1627 | 1839 | 1839.0 | 69.2 | 69.2 | Physiological aspects of primary hypertension. | B Folkow | Physiol Rev | 1982 | 6461865 | No |
| 1628 | 3678 | 1839.0 | 87.6 | 43.8 | The BCL-2 protein family: opposing activities that mediate cell death. | Richard J Youle, Andreas Strasser | Nat Rev Mol Cell Biol | 2008 | 18097445 | No |
| 1629 | 3675 | 1837.5 | 100.7 | 50.4 | Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. | Gerard Talavera, Jose Castresana | Syst Biol | 2007 | 17654362 | Yes |
| 1630 | 3674 | 1837.0 | 106.9 | 53.5 | Early identification of refractory epilepsy. | P Kwan, M J Brodie | N Engl J Med | 2000 | 10660394 | Yes |
| 1631 | 3673 | 1836.5 | 179.9 | 90.0 | Natural Products as Sources of New Drugs from 1981 to 2014. | David J Newman, Gordon M Cragg | J Nat Prod | 2016 | 26852623 | No |
| 1632 | 7342 | 1835.5 | 242.3 | 60.6 | A rating scale for mania: reliability, validity and sensitivity. | R C Young, J T Biggs, V E Ziegler, D A Meyer | Br J Psychiatry | 1978 | 728692 | Yes |
| 1633 | 1835 | 1835.0 | 50.6 | 50.6 | Mitochondria and cancer. | Douglas C Wallace | Nat Rev Cancer | 2012 | 23001348 | No |
| 1634 | 1835 | 1835.0 | 77.4 | 77.4 | Biological roles of glycans. | Ajit Varki | Glycobiology | 2017 | 27558841 | No |
| 1635 | 1835 | 1835.0 | 70.0 | 70.0 | Inflammation, metaflammation and immunometabolic disorders. | Gokhan S Hotamisligil | Nature | 2017 | 28179656 | No |
| 1636 | 3669 | 1834.5 | 77.8 | 38.9 | Fitting a mixture model by expectation maximization to discover motifs in biopolymers. | T L Bailey, C Elkan | Proc Int Conf Intell Syst Mol Biol | 1994 | 7584402 | Yes |
| 1637 | 1833 | 1833.0 | 33.6 | 33.6 | The relationship between the spleen colony-forming cell and the haemopoietic stem cell. | R Schofield | Blood Cells | 1978 | 747780 | Yes |
| 1638 | 1833 | 1833.0 | 71.7 | 71.7 | Dual-task interference in simple tasks: data and theory. | H Pashler | Psychol Bull | 1994 | 7972591 | No |
| 1639 | 1831 | 1831.0 | 44.9 | 44.9 | New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. | R Y Tsien | Biochemistry | 1980 | 6770893 | Yes |
| 1640 | 5493 | 1831.0 | 189.5 | 63.2 | A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. | J R Le Gall, S Lemeshow, F Saulnier | JAMA | 1993 | 8254858 | Yes |
| 1641 | 1830 | 1830.0 | 39.8 | 39.8 | Structure and regulation of voltage-gated Ca2+ channels. | W A Catterall | Annu Rev Cell Dev Biol | 2000 | 11031246 | No |
| 1642 | 9145 | 1829.0 | 410.9 | 82.2 | CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes. | Donovan H Parks, Michael Imelfort, Connor T Skennerton, Philip Hugenholtz, Gene W Tyson | Genome Res | 2015 | 25977477 | Yes |
| 1643 | 1828 | 1828.0 | 47.3 | 47.3 | Wound healing and its impairment in the diabetic foot. | Vincent Falanga | Lancet | 2005 | 16291068 | No |
| 1644 | 1827 | 1827.0 | 78.5 | 78.5 | The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. | Costantino Iadecola | Neuron | 2017 | 28957666 | No |
| 1645 | 1826 | 1826.0 | 50.0 | 50.0 | Efficient analysis of experimental observations. | W J Dixon | Annu Rev Pharmacol Toxicol | 1980 | 7387124 | Yes |
| 1646 | 1826 | 1826.0 | 38.8 | 38.8 | Neurotrophins and their receptors: a convergence point for many signalling pathways. | Moses V Chao | Nat Rev Neurosci | 2003 | 12671646 | No |
| 1647 | 5476 | 1825.3 | 133.7 | 44.6 | A rapid method for the isolation of functional thymus-derived murine lymphocytes. | M H Julius, E Simpson, L A Herzenberg | Eur J Immunol | 1973 | 4587740 | Yes |
| 1648 | 1825 | 1825.0 | 64.3 | 64.3 | A cortical network for directed attention and unilateral neglect. | M M Mesulam | Ann Neurol | 1981 | 7032417 | No |
| 1649 | 1825 | 1825.0 | 90.5 | 90.5 | The structure and properties of the sense of coherence scale. | A Antonovsky | Soc Sci Med | 1993 | 8480217 | Yes |
| 1650 | 1825 | 1825.0 | 41.8 | 41.8 | An approximately unbiased test of phylogenetic tree selection. | Hidetoshi Shimodaira | Syst Biol | 2002 | 12079646 | Yes |
| 1651 | 1824 | 1824.0 | 0.0 | 0.0 | Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. | S Cohen | J Biol Chem | 1962 | 13880319 | Yes |
| 1652 | 1824 | 1824.0 | 42.8 | 42.8 | Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. | Kang Xu | Chem Rev | 2004 | 15669157 | Yes |
| 1653 | 1824 | 1824.0 | 0.0 | 0.0 | Impulses and Physiological States in Theoretical Models of Nerve Membrane. | R Fitzhugh | Biophys J | 1961 | 19431309 | Yes |
| 1654 | 1824 | 1824.0 | 57.8 | 57.8 | Asthma phenotypes: the evolution from clinical to molecular approaches. | Sally E Wenzel | Nat Med | 2012 | 22561835 | No |
| 1655 | 18219 | 1821.9 | 588.5 | 58.9 | Measurement of protein using bicinchoninic acid. | P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk | Anal Biochem | 1985 | 3843705 | Yes |
| 1656 | 9108 | 1821.6 | 325.9 | 65.2 | Integrating single-cell transcriptomic data across different conditions, technologies, and species. | Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul Satija | Nat Biotechnol | 2018 | 29608179 | Yes |
| 1657 | 21852 | 1821.0 | 702.8 | 58.6 | A new equation to estimate glomerular filtration rate. | Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh, | Ann Intern Med | 2009 | 19414839 | Yes |
| 1658 | 1821 | 1821.0 | 69.3 | 69.3 | Structure, Function, and Evolution of Coronavirus Spike Proteins. | Fang Li | Annu Rev Virol | 2016 | 27578435 | No |
| 1659 | 3641 | 1820.5 | 144.5 | 72.2 | The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities. | Samuel Genheden, Ulf Ryde | Expert Opin Drug Discov | 2015 | 25835573 | No |
| 1660 | 1820 | 1820.0 | 46.8 | 46.8 | Synaptic density in human frontal cortex - developmental changes and effects of aging. | P R Huttenlocher | Brain Res | 1979 | 427544 | Yes |
| 1661 | 3640 | 1820.0 | 110.1 | 55.0 | Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. | Riccardo Lencioni, Josep M Llovet | Semin Liver Dis | 2010 | 20175033 | No |
| 1662 | 5453 | 1817.7 | 139.4 | 46.5 | Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. | Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Orntoft | Cancer Res | 2004 | 15289330 | Yes |
| 1663 | 3635 | 1817.5 | 68.3 | 34.1 | The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. | J O'Keefe, J Dostrovsky | Brain Res | 1971 | 5124915 | Yes |
| 1664 | 1816 | 1816.0 | 52.9 | 52.9 | Stress and depression. | Constance Hammen | Annu Rev Clin Psychol | 2005 | 17716090 | No |
| 1665 | 5447 | 1815.7 | 136.1 | 45.4 | Membrane lipids: where they are and how they behave. | Gerrit Van Meer, Dennis R Voelker, Gerald W Feigenson | Nat Rev Mol Cell Biol | 2008 | 18216768 | No |
| 1666 | 3630 | 1815.0 | 94.9 | 47.5 | Molecular mechanisms of long noncoding RNAs. | Kevin C Wang, Howard Y Chang | Mol Cell | 2011 | 21925379 | No |
| 1667 | 1814 | 1814.0 | 33.6 | 33.6 | Why genes in pieces? | W Gilbert | Nature | 1978 | 622185 | Yes |
| 1668 | 1814 | 1814.0 | 60.3 | 60.3 | Heavy metal intensification of DAB-based HRP reaction product. | J C Adams | J Histochem Cytochem | 1981 | 7252134 | Yes |
| 1669 | 1814 | 1814.0 | 40.5 | 40.5 | AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. | D Grahame Hardie | Nat Rev Mol Cell Biol | 2007 | 17712357 | No |
| 1670 | 1813 | 1813.0 | 0.0 | 0.0 | The genetical evolution of social behaviour. II. | W D Hamilton | J Theor Biol | 1964 | 5875340 | Yes |
| 1671 | 1812 | 1812.0 | 45.2 | 45.2 | Clinical features of metastatic bone disease and risk of skeletal morbidity. | Robert E Coleman | Clin Cancer Res | 2006 | 17062708 | No |
| 1672 | 1812 | 1812.0 | 59.5 | 59.5 | Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. | Lutz Ackermann | Chem Rev | 2011 | 21391562 | Yes |
| 1673 | 3623 | 1811.5 | 107.3 | 53.6 | Molecular and cellular insights into T cell exhaustion. | E John Wherry, Makoto Kurachi | Nat Rev Immunol | 2015 | 26205583 | No |
| 1674 | 9056 | 1811.2 | 339.9 | 68.0 | Fsl. | Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M Smith | Neuroimage | 2012 | 21979382 | No |
| 1675 | 1811 | 1811.0 | 31.6 | 31.6 | Amino acid difference formula to help explain protein evolution. | R Grantham | Science | 1974 | 4843792 | Yes |
| 1676 | 1809 | 1809.0 | 53.4 | 53.4 | THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. | Kozi Asada | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012221 | Yes |
| 1677 | 3617 | 1808.5 | 119.9 | 60.0 | The M1 and M2 paradigm of macrophage activation: time for reassessment. | Fernando O Martinez, Siamon Gordon | F1000Prime Rep | 2014 | 24669294 | No |
| 1678 | 1808 | 1808.0 | 41.6 | 41.6 | Tumor angiogenesis. | Robert S Kerbel | N Engl J Med | 2008 | 18463380 | No |
| 1679 | 3615 | 1807.5 | 90.4 | 45.2 | Adipose tissue as an endocrine organ. | Erin E Kershaw, Jeffrey S Flier | J Clin Endocrinol Metab | 2004 | 15181022 | No |
| 1680 | 1805 | 1805.0 | 62.9 | 62.9 | The linear-quadratic formula and progress in fractionated radiotherapy. | J F Fowler | Br J Radiol | 1989 | 2670032 | No |
| 1681 | 1805 | 1805.0 | 62.4 | 62.4 | Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. | S Katz | J Am Geriatr Soc | 1983 | 6418786 | No |
| 1682 | 3609 | 1804.5 | 89.9 | 45.0 | Protein folding in the cell. | M J Gething, J Sambrook | Nature | 1992 | 1731198 | No |
| 1683 | 3608 | 1804.0 | 138.4 | 69.2 | 3D bioprinting of tissues and organs. | Sean V Murphy, Anthony Atala | Nat Biotechnol | 2014 | 25093879 | Yes |
| 1684 | 16229 | 1803.2 | 558.4 | 62.0 | The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. | D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar | J Clin Psychiatry | 1998 | 9881538 | No |
| 1685 | 1803 | 1803.0 | 61.2 | 61.2 | Pineal melatonin: cell biology of its synthesis and of its physiological interactions. | R J Reiter | Endocr Rev | 1991 | 1649044 | No |
| 1686 | 3606 | 1803.0 | 96.4 | 48.2 | The biology of vascular endothelial growth factor. | N Ferrara, T Davis-Smyth | Endocr Rev | 1997 | 9034784 | No |
| 1687 | 1802 | 1802.0 | 80.8 | 80.8 | Estimability and estimation in case-referent studies. | O Miettinen | Am J Epidemiol | 1976 | 1251836 | Yes |
| 1688 | 3604 | 1802.0 | 143.7 | 71.8 | A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. | J G Snodgrass, M Vanderwart | J Exp Psychol Hum Learn | 1980 | 7373248 | Yes |
| 1689 | 3603 | 1801.5 | 95.3 | 47.6 | Morris water maze: procedures for assessing spatial and related forms of learning and memory. | Charles V Vorhees, Michael T Williams | Nat Protoc | 2006 | 17406317 | Yes |
| 1690 | 3603 | 1801.5 | 87.1 | 43.5 | Cell signaling by receptor tyrosine kinases. | Mark A Lemmon, Joseph Schlessinger | Cell | 2010 | 20602996 | No |
| 1691 | 1801 | 1801.0 | 70.2 | 70.2 | Modeling and variable selection in epidemiologic analysis. | S Greenland | Am J Public Health | 1989 | 2916724 | Yes |
| 1692 | 1800 | 1800.0 | 0.0 | 0.0 | The measurement of volume changes in human limbs. | R J Whitney | J Physiol | 1953 | 13085295 | Yes |
| 1693 | 1798 | 1798.0 | 40.8 | 40.8 | Areas, volumes, packing and protein structure. | F M Richards | Annu Rev Biophys Bioeng | 1977 | 326146 | No |
| 1694 | 1798 | 1798.0 | 77.0 | 77.0 | PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. | Anthony L Spek | Acta Crystallogr C Struct Chem | 2015 | 25567569 | Yes |
| 1695 | 1797 | 1797.0 | 64.6 | 64.6 | Paced auditory serial-addition task: a measure of recovery from concussion. | D M Gronwall | Percept Mot Skills | 1977 | 866038 | Yes |
| 1696 | 1797 | 1797.0 | 61.2 | 61.2 | Serum albumin. | T Peters | Adv Protein Chem | 1985 | 3904348 | No |
| 1697 | 3592 | 1796.0 | 105.7 | 52.9 | Quality control and preprocessing of metagenomic datasets. | Robert Schmieder, Robert Edwards | Bioinformatics | 2011 | 21278185 | Yes |
| 1698 | 1795 | 1795.0 | 51.7 | 51.7 | Oxidative stress hypothesis in Alzheimer's disease. | W R Markesbery | Free Radic Biol Med | 1997 | 9165306 | No |
| 1699 | 8975 | 1795.0 | 341.4 | 68.3 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | J Clin Epidemiol | 2009 | 19631508 | No |
| 1700 | 1794 | 1794.0 | 57.2 | 57.2 | Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. | E M Wassermann | Electroencephalogr Clin Neurophysiol | 1998 | 9474057 | No |
| 1701 | 1794 | 1794.0 | 0.0 | 0.0 | The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. | S Hestrin | J Biol Chem | 1949 | 18133390 | Yes |
| 1702 | 1794 | 1794.0 | 79.0 | 79.0 | The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health. | Lisa Bowleg | Am J Public Health | 2012 | 22594719 | Yes |
| 1703 | 3586 | 1793.0 | 89.8 | 44.9 | Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. | Robert Visse, Hideaki Nagase | Circ Res | 2003 | 12730128 | No |
| 1704 | 1793 | 1793.0 | 35.9 | 35.9 | The synaptic vesicle cycle. | Thomas C Sudhof | Annu Rev Neurosci | 2004 | 15217342 | No |
| 1705 | 1793 | 1793.0 | 71.1 | 71.1 | Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation. | Karimollah Hajian-Tilaki | Caspian J Intern Med | 2013 | 24009950 | No |
| 1706 | 3586 | 1793.0 | 212.5 | 106.2 | Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. | Helmut Sies, Dean P Jones | Nat Rev Mol Cell Biol | 2020 | 32231263 | No |
| 1707 | 5378 | 1792.7 | 119.1 | 39.7 | An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. | J K Eng, A L McCormack, J R Yates | J Am Soc Mass Spectrom | 1994 | 24226387 | Yes |
| 1708 | 3584 | 1792.0 | 128.2 | 64.1 | Multiple receptors for dopamine. | J W Kebabian, D B Calne | Nature | 1979 | 215920 | No |
| 1709 | 1792 | 1792.0 | 65.2 | 65.2 | The case-crossover design: a method for studying transient effects on the risk of acute events. | M MacLure | Am J Epidemiol | 1991 | 1985444 | Yes |
| 1710 | 1791 | 1791.0 | 83.0 | 83.0 | Human agency in social cognitive theory. | A Bandura | Am Psychol | 1989 | 2782727 | Yes |
| 1711 | 5373 | 1791.0 | 128.6 | 42.9 | Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. | Prateek Kumar, Steven Henikoff, Pauline C Ng | Nat Protoc | 2009 | 19561590 | Yes |
| 1712 | 3582 | 1791.0 | 135.4 | 67.7 | The Warburg Effect: How Does it Benefit Cancer Cells? | Maria V Liberti, Jason W Locasale | Trends Biochem Sci | 2016 | 26778478 | No |
| 1713 | 3578 | 1789.0 | 137.3 | 68.7 | Universal chemical assay for the detection and determination of siderophores. | B Schwyn, J B Neilands | Anal Biochem | 1987 | 2952030 | Yes |
| 1714 | 7155 | 1788.8 | 318.0 | 79.5 | NF-κB signaling in inflammation. | Ting Liu, Lingyun Zhang, Donghyun Joo, Shao-Cong Sun | Signal Transduct Target Ther | 2017 | 29158945 | Yes |
| 1715 | 1788 | 1788.0 | 41.9 | 41.9 | Introduction to NF-kappaB: players, pathways, perspectives. | T D Gilmore | Oncogene | 2006 | 17072321 | No |
| 1716 | 1788 | 1788.0 | 48.1 | 48.1 | BEDTools: The Swiss-Army Tool for Genome Feature Analysis. | Aaron R Quinlan | Curr Protoc Bioinformatics | 2014 | 25199790 | Yes |
| 1717 | 1787 | 1787.0 | 33.1 | 33.1 | Simple memory: a theory for archicortex. | D Marr | Philos Trans R Soc Lond B Biol Sci | 1971 | 4399412 | Yes |
| 1718 | 1787 | 1787.0 | 39.5 | 39.5 | The tumor microenvironment and its role in promoting tumor growth. | T L Whiteside | Oncogene | 2008 | 18836471 | No |
| 1719 | 3574 | 1787.0 | 98.5 | 49.2 | Accessories to the crime: functions of cells recruited to the tumor microenvironment. | Douglas Hanahan, Lisa M Coussens | Cancer Cell | 2012 | 22439926 | No |
| 1720 | 10721 | 1786.8 | 226.3 | 37.7 | Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. | A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello | Nature | 1998 | 9486653 | Yes |
| 1721 | 1786 | 1786.0 | 52.5 | 52.5 | Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4332693 | Yes |
| 1722 | 1786 | 1786.0 | 35.9 | 35.9 | Generating samples under a Wright-Fisher neutral model of genetic variation. | Richard R Hudson | Bioinformatics | 2002 | 11847089 | Yes |
| 1723 | 1786 | 1786.0 | 56.6 | 56.6 | Amino acids: metabolism, functions, and nutrition. | Guoyao Wu | Amino Acids | 2009 | 19301095 | No |
| 1724 | 1784 | 1784.0 | 65.8 | 65.8 | Computerized transverse axial scanning (tomography). 1. Description of system. | G N Hounsfield | Br J Radiol | 1973 | 4757352 | Yes |
| 1725 | 1784 | 1784.0 | 0.0 | 0.0 | Notes on continuous stochastic phenomena. | P A P Moran | Biometrika | 1950 | 15420245 | Yes |
| 1726 | 3567 | 1783.5 | 96.6 | 48.3 | EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. | Stefan Stoll, Arthur Schweiger | J Magn Reson | 2006 | 16188474 | Yes |
| 1727 | 1783 | 1783.0 | 41.2 | 41.2 | Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. | M J Casadaban | J Mol Biol | 1976 | 781293 | Yes |
| 1728 | 1783 | 1783.0 | 42.4 | 42.4 | Solvent-accessible surfaces of proteins and nucleic acids. | M L Connolly | Science | 1983 | 6879170 | Yes |
| 1729 | 1783 | 1783.0 | 71.3 | 71.3 | Rhythms for Cognition: Communication through Coherence. | Pascal Fries | Neuron | 2015 | 26447583 | No |
| 1730 | 5347 | 1782.3 | 174.2 | 58.1 | Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. | H Esterbauer, R J Schaur, H Zollner | Free Radic Biol Med | 1991 | 1937131 | No |
| 1731 | 3564 | 1782.0 | 95.8 | 47.9 | Matrix metalloproteinases. | H Nagase, J F Woessner | J Biol Chem | 1999 | 10419448 | No |
| 1732 | 1781 | 1781.0 | 62.9 | 62.9 | A Social Neuroscience Perspective on Adolescent Risk-Taking. | Laurence Steinberg | Dev Rev | 2008 | 18509515 | Yes |
| 1733 | 3560 | 1780.0 | 96.9 | 48.5 | Maturation of the head of bacteriophage T4. I. DNA packaging events. | U K Laemmli, M Favre | J Mol Biol | 1973 | 4204102 | Yes |
| 1734 | 3560 | 1780.0 | 95.0 | 47.5 | The gut microbiota shapes intestinal immune responses during health and disease. | June L Round, Sarkis K Mazmanian | Nat Rev Immunol | 2009 | 19343057 | No |
| 1735 | 1777 | 1777.0 | 72.5 | 72.5 | A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. | D J Schuirmann | J Pharmacokinet Biopharm | 1987 | 3450848 | Yes |
| 1736 | 1777 | 1777.0 | 29.9 | 29.9 | Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. | J N Dumont | J Morphol | 1972 | 4109871 | Yes |
| 1737 | 1777 | 1777.0 | 57.8 | 57.8 | The in vitro micronucleus technique. | M Fenech | Mutat Res | 2000 | 11113469 | No |
| 1738 | 3553 | 1776.5 | 147.0 | 73.5 | A typology of reviews: an analysis of 14 review types and associated methodologies. | Maria J Grant, Andrew Booth | Health Info Libr J | 2009 | 19490148 | No |
| 1739 | 1776 | 1776.0 | 37.8 | 37.8 | An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. | R M Esnouf | J Mol Graph Model | 1997 | 9385560 | Yes |
| 1740 | 3550 | 1775.0 | 125.2 | 62.6 | A fluorometric method for determination of oxidized and reduced glutathione in tissues. | P J Hissin, R Hilf | Anal Biochem | 1976 | 962076 | Yes |
| 1741 | 1775 | 1775.0 | 63.3 | 63.3 | Drugs of abuse: anatomy, pharmacology and function of reward pathways. | G F Koob | Trends Pharmacol Sci | 1992 | 1604710 | No |
| 1742 | 3550 | 1775.0 | 85.3 | 42.6 | Lipopolysaccharide endotoxins. | Christian R H Raetz, Chris Whitfield | Annu Rev Biochem | 2002 | 12045108 | No |
| 1743 | 1775 | 1775.0 | 0.0 | 0.0 | Cerebral vascular accidents in patients over the age of 60. II. Prognosis. | J Rankin | Scott Med J | 1957 | 13432835 | Yes |
| 1744 | 3549 | 1774.5 | 78.5 | 39.2 | Integrin signaling. | F G Giancotti, E Ruoslahti | Science | 1999 | 10446041 | No |
| 1745 | 3548 | 1774.0 | 107.6 | 53.8 | Density functionals with broad applicability in chemistry. | Yan Zhao, Donald G Truhlar | Acc Chem Res | 2008 | 18186612 | Yes |
| 1746 | 3547 | 1773.5 | 92.6 | 46.3 | Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. | Steven E Nissen, Kathy Wolski | N Engl J Med | 2007 | 17517853 | Yes |
| 1747 | 7092 | 1773.0 | 309.7 | 77.4 | The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. | S P Baker, B O'Neill, W Haddon, W B Long | J Trauma | 1974 | 4814394 | Yes |
| 1748 | 1773 | 1773.0 | 42.2 | 42.2 | In vivo near-infrared fluorescence imaging. | John V Frangioni | Curr Opin Chem Biol | 2003 | 14580568 | No |
| 1749 | 3545 | 1772.5 | 149.1 | 74.5 | Assessment of eating disorders: interview or self-report questionnaire? | C G Fairburn, S J Beglin | Int J Eat Disord | 1994 | 7866415 | Yes |
| 1750 | 3541 | 1770.5 | 173.1 | 86.5 | The structure of coping. | L I Pearlin, C Schooler | J Health Soc Behav | 1978 | 649936 | Yes |
| 1751 | 3541 | 1770.5 | 112.4 | 56.2 | Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. | Sally S Dickerson, Margaret E Kemeny | Psychol Bull | 2004 | 15122924 | Yes |
| 1752 | 1770 | 1770.0 | 47.4 | 47.4 | A more meaningful scoring system for determining the severity of coronary heart disease. | G G Gensini | Am J Cardiol | 1983 | 6823874 | Yes |
| 1753 | 1770 | 1770.0 | 56.0 | 56.0 | The Hospital Anxiety And Depression Scale. | R Philip Snaith | Health Qual Life Outcomes | 2003 | 12914662 | Yes |
| 1754 | 1768 | 1768.0 | 48.1 | 48.1 | Interleukin-6: an overview. | J Van Snick | Annu Rev Immunol | 1990 | 2188664 | No |
| 1755 | 3536 | 1768.0 | 0.0 | 0.0 | A complementation analysis of the restriction and modification of DNA in Escherichia coli. | H W Boyer, D Roulland-Dussoix | J Mol Biol | 1969 | 4896022 | Yes |
| 1756 | 1767 | 1767.0 | 30.4 | 30.4 | Mode of cell migration to the superficial layers of fetal monkey neocortex. | P Rakic | J Comp Neurol | 1972 | 4624784 | Yes |
| 1757 | 1767 | 1767.0 | 59.7 | 59.7 | PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints. | Chun Wei Yap | J Comput Chem | 2011 | 21425294 | Yes |
| 1758 | 1766 | 1766.0 | 0.0 | 0.0 | Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. | J Spizizen | Proc Natl Acad Sci U S A | 1958 | 16590310 | Yes |
| 1759 | 1766 | 1766.0 | 41.7 | 41.7 | Angiogenesis: an organizing principle for drug discovery? | Judah Folkman | Nat Rev Drug Discov | 2007 | 17396134 | No |
| 1760 | 3529 | 1764.5 | 76.3 | 38.1 | The epigenomics of cancer. | Peter A Jones, Stephen B Baylin | Cell | 2007 | 17320506 | No |
| 1761 | 1764 | 1764.0 | 60.7 | 60.7 | The law of attrition. | Gunther Eysenbach | J Med Internet Res | 2005 | 15829473 | Yes |
| 1762 | 3527 | 1763.5 | 94.3 | 47.1 | Prediction of protein antigenic determinants from amino acid sequences. | T P Hopp, K R Woods | Proc Natl Acad Sci U S A | 1981 | 6167991 | Yes |
| 1763 | 3526 | 1763.0 | 129.2 | 64.6 | Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. | Roel Nusse, Hans Clevers | Cell | 2017 | 28575679 | No |
| 1764 | 1762 | 1762.0 | 0.0 | 0.0 | ATPase activity of myosin correlated with speed of muscle shortening. | M Barany | J Gen Physiol | 1967 | 4227924 | Yes |
| 1765 | 1762 | 1762.0 | 70.2 | 70.2 | Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. | K Anders Ericsson | Acad Med | 2004 | 15383395 | No |
| 1766 | 3522 | 1761.0 | 80.2 | 40.1 | Escaping free-energy minima. | Alessandro Laio, Michele Parrinello | Proc Natl Acad Sci U S A | 2002 | 12271136 | Yes |
| 1767 | 1759 | 1759.0 | 0.0 | 0.0 | A personality scale of manifest anxiety. | J A Taylor | J Abnorm Psychol | 1953 | 13052352 | Yes |
| 1768 | 3516 | 1758.0 | 232.1 | 116.0 | A clinical method of functional assessment of the shoulder. | C R Constant, A H Murley | Clin Orthop Relat Res | 1987 | 3791738 | Yes |
| 1769 | 1758 | 1758.0 | 43.4 | 43.4 | Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. | S A Bustin | J Mol Endocrinol | 2002 | 12200227 | No |
| 1770 | 7031 | 1757.8 | 233.1 | 58.3 | SignalP 4.0: discriminating signal peptides from transmembrane regions. | Thomas Nordahl Petersen, Soren Brunak, Gunnar Von Heijne, Henrik Nielsen | Nat Methods | 2011 | 21959131 | Yes |
| 1771 | 1757 | 1757.0 | 41.3 | 41.3 | Steroid receptor regulated transcription of specific genes and gene networks. | K R Yamamoto | Annu Rev Genet | 1985 | 3909942 | No |
| 1772 | 1757 | 1757.0 | 49.1 | 49.1 | G proteins and dual control of adenylate cyclase. | A G Gilman | Cell | 1984 | 6321035 | Yes |
| 1773 | 1756 | 1756.0 | 56.4 | 56.4 | Glutamate: a neurotransmitter in mammalian brain. | F Fonnum | J Neurochem | 1984 | 6139418 | No |
| 1774 | 1756 | 1756.0 | 39.7 | 39.7 | The synaptic vesicle cycle: a cascade of protein-protein interactions. | T C Sudhof | Nature | 1995 | 7791897 | No |
| 1775 | 1756 | 1756.0 | 65.0 | 65.0 | Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? | B Halliwell | Lancet | 1994 | 7915779 | No |
| 1776 | 1756 | 1756.0 | 152.1 | 152.1 | COVID-19 and mental health: A review of the existing literature. | Ravi Philip Rajkumar | Asian J Psychiatr | 2020 | 32302935 | Yes |
| 1777 | 3511 | 1755.5 | 75.2 | 37.6 | Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. | Gary L Johnson, Razvan Lapadat | Science | 2002 | 12471242 | No |
| 1778 | 3509 | 1754.5 | 97.0 | 48.5 | Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. | K B Mullis, F A Faloona | Methods Enzymol | 1987 | 3431465 | Yes |
| 1779 | 1753 | 1753.0 | 39.6 | 39.6 | Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. | A Krishan | J Cell Biol | 1975 | 49354 | Yes |
| 1780 | 1753 | 1753.0 | 56.6 | 56.6 | Dynamic properties of mammalian skeletal muscles. | R I Close | Physiol Rev | 1972 | 4256989 | No |
| 1781 | 7009 | 1752.2 | 139.0 | 34.8 | Transformation of intact yeast cells treated with alkali cations. | H Ito, Y Fukuda, K Murata, A Kimura | J Bacteriol | 1983 | 6336730 | Yes |
| 1782 | 1752 | 1752.0 | 0.0 | 0.0 | Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. | A F Habeeb | Anal Biochem | 1966 | 4161471 | Yes |
| 1783 | 3504 | 1752.0 | 72.8 | 36.4 | The evolutionary fate and consequences of duplicate genes. | M Lynch, J S Conery | Science | 2000 | 11073452 | No |
| 1784 | 1752 | 1752.0 | 69.3 | 69.3 | MorphoJ: an integrated software package for geometric morphometrics. | Christian Peter Klingenberg | Mol Ecol Resour | 2011 | 21429143 | Yes |
| 1785 | 1751 | 1751.0 | 31.0 | 31.0 | Transplacental carcinogenesis by stilbestrol. | J Folkman | N Engl J Med | 1971 | 5556579 | Yes |
| 1786 | 5252 | 1750.7 | 217.1 | 72.4 | Impact of Event Scale: a measure of subjective stress. | M Horowitz, N Wilner, W Alvarez | Psychosom Med | 1979 | 472086 | Yes |
| 1787 | 10497 | 1749.5 | 304.0 | 50.7 | Positional cloning of the mouse obese gene and its human homologue. | Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman | Nature | 1994 | 7984236 | Yes |
| 1788 | 1749 | 1749.0 | 71.6 | 71.6 | Negative symptoms in schizophrenia. Definition and reliability. | N C Andreasen | Arch Gen Psychiatry | 1982 | 7165477 | Yes |
| 1789 | 5245 | 1748.3 | 115.0 | 38.3 | Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. | J E Darnell, I M Kerr, G R Stark | Science | 1994 | 8197455 | No |
| 1790 | 1748 | 1748.0 | 56.0 | 56.0 | The role of hormone receptors and GTP-regulatory proteins in membrane transduction. | M Rodbell | Nature | 1980 | 6101906 | Yes |
| 1791 | 3496 | 1748.0 | 93.8 | 46.9 | Quantum dot bioconjugates for ultrasensitive nonisotopic detection. | W C Chan, S Nie | Science | 1998 | 9748158 | Yes |
| 1792 | 3494 | 1747.0 | 75.6 | 37.8 | A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. | D Wessel, U I Flugge | Anal Biochem | 1984 | 6731838 | Yes |
| 1793 | 1747 | 1747.0 | 50.7 | 50.7 | Surface plasmon resonance sensors for detection of chemical and biological species. | Jiri Homola | Chem Rev | 2008 | 18229953 | No |
| 1794 | 5240 | 1746.7 | 226.8 | 75.6 | The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. | C A McHorney, J E Ware, A E Raczek | Med Care | 1993 | 8450681 | Yes |
| 1795 | 1746 | 1746.0 | 35.8 | 35.8 | DNA in a material world. | Nadrian C Seeman | Nature | 2003 | 12540916 | No |
| 1796 | 3492 | 1746.0 | 115.9 | 58.0 | Mendelian randomization: genetic anchors for causal inference in epidemiological studies. | George Davey Smith, Gibran Hemani | Hum Mol Genet | 2014 | 25064373 | No |
| 1797 | 1745 | 1745.0 | 49.6 | 49.6 | Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. | M Wong-Riley | Brain Res | 1979 | 223730 | Yes |
| 1798 | 3490 | 1745.0 | 77.3 | 38.6 | Cellular senescence: when bad things happen to good cells. | Judith Campisi, Fabrizio D'Adda Di Fagagna | Nat Rev Mol Cell Biol | 2007 | 17667954 | No |
| 1799 | 3489 | 1744.5 | 91.1 | 45.5 | CAP3: A DNA sequence assembly program. | X Huang, A Madan | Genome Res | 1999 | 10508846 | Yes |
| 1800 | 1744 | 1744.0 | 40.9 | 40.9 | Effects of cytochalasin and phalloidin on actin. | J A Cooper | J Cell Biol | 1987 | 3312229 | No |
| 1801 | 1744 | 1744.0 | 52.3 | 52.3 | The basal ganglia: focused selection and inhibition of competing motor programs. | J W Mink | Prog Neurobiol | 1996 | 9004351 | No |
| 1802 | 3487 | 1743.5 | 77.5 | 38.8 | The Ki-67 protein: from the known and the unknown. | T Scholzen, J Gerdes | J Cell Physiol | 2000 | 10653597 | No |
| 1803 | 3484 | 1742.0 | 85.0 | 42.5 | Unravelling the pathogenesis of inflammatory bowel disease. | R J Xavier, D K Podolsky | Nature | 2007 | 17653185 | No |
| 1804 | 1742 | 1742.0 | 0.0 | 0.0 | The general adaptation syndrome and the diseases of adaptation. | H Selye | J Clin Endocrinol Metab | 1946 | 21025115 | Yes |
| 1805 | 17414 | 1741.4 | 569.5 | 57.0 | The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. | F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra | Arthritis Rheum | 1988 | 3358796 | Yes |
| 1806 | 3482 | 1741.0 | 81.5 | 40.8 | Neurotrophins: roles in neuronal development and function. | E J Huang, L F Reichardt | Annu Rev Neurosci | 2001 | 11520916 | No |
| 1807 | 1741 | 1741.0 | 32.5 | 32.5 | Neuroblastoma: biological insights into a clinical enigma. | Garrett M Brodeur | Nat Rev Cancer | 2003 | 12612655 | No |
| 1808 | 3482 | 1741.0 | 199.6 | 99.8 | Osteoarthritis. | David J Hunter, Sita Bierma-Zeinstra | Lancet | 2019 | 31034380 | No |
| 1809 | 5222 | 1740.7 | 124.4 | 41.5 | Click Chemistry: Diverse Chemical Function from a Few Good Reactions. | Hartmuth C Kolb, M G Finn, K Barry Sharpless | Angew Chem Int Ed Engl | 2001 | 11433435 | Yes |
| 1810 | 3480 | 1740.0 | 209.2 | 104.6 | Rating systems in the evaluation of knee ligament injuries. | Y Tegner, J Lysholm | Clin Orthop Relat Res | 1985 | 4028566 | Yes |
| 1811 | 1740 | 1740.0 | 57.0 | 57.0 | A measure of population subdivision based on microsatellite allele frequencies. | M Slatkin | Genetics | 1995 | 7705646 | Yes |
| 1812 | 8700 | 1740.0 | 315.6 | 63.1 | Salmon provides fast and bias-aware quantification of transcript expression. | Rob Patro, Geet Duggal, Michael I Love, Rafael A Irizarry, Carl Kingsford | Nat Methods | 2017 | 28263959 | Yes |
| 1813 | 3478 | 1739.0 | 108.4 | 54.2 | The cortical organization of speech processing. | Gregory Hickok, David Poeppel | Nat Rev Neurosci | 2007 | 17431404 | No |
| 1814 | 6956 | 1739.0 | 174.6 | 43.6 | CHARMM-GUI: a web-based graphical user interface for CHARMM. | Sunhwan Jo, Taehoon Kim, Vidyashankara G Iyer, Wonpil Im | J Comput Chem | 2008 | 18351591 | No |
| 1815 | 1738 | 1738.0 | 58.2 | 58.2 | Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. | C E Mogensen | N Engl J Med | 1984 | 6690964 | Yes |
| 1816 | 1738 | 1738.0 | 38.9 | 38.9 | Critical period plasticity in local cortical circuits. | Takao K Hensch | Nat Rev Neurosci | 2005 | 16261181 | No |
| 1817 | 6951 | 1737.8 | 282.8 | 70.7 | Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. | Jack Bowden, George Davey Smith, Philip C Haycock, Stephen Burgess | Genet Epidemiol | 2016 | 27061298 | Yes |
| 1818 | 1736 | 1736.0 | 42.2 | 42.2 | Neurovascular regulation in the normal brain and in Alzheimer's disease. | Costantino Iadecola | Nat Rev Neurosci | 2004 | 15100718 | No |
| 1819 | 10414 | 1735.7 | 396.1 | 66.0 | Antioxidant activity applying an improved ABTS radical cation decolorization assay. | R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans | Free Radic Biol Med | 1999 | 10381194 | Yes |
| 1820 | 1735 | 1735.0 | 75.3 | 75.3 | The micronucleus test. | W Schmid | Mutat Res | 1975 | 48190 | Yes |
| 1821 | 5205 | 1735.0 | 135.2 | 45.1 | Optimization by simulated annealing. | S Kirkpatrick, C D Gelatt, M P Vecchi | Science | 1983 | 17813860 | Yes |
| 1822 | 1735 | 1735.0 | 49.4 | 49.4 | Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. | Charles A Dinarello | Blood | 2011 | 21304099 | No |
| 1823 | 1735 | 1735.0 | 75.6 | 75.6 | Sleep health: can we define it? Does it matter? | Daniel J Buysse | Sleep | 2014 | 24470692 | Yes |
| 1824 | 5204 | 1734.7 | 152.7 | 50.9 | Dose translation from animal to human studies revisited. | Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad | FASEB J | 2008 | 17942826 | Yes |
| 1825 | 1734 | 1734.0 | 32.7 | 32.7 | Cyclin-dependent kinases: engines, clocks, and microprocessors. | D O Morgan | Annu Rev Cell Dev Biol | 1997 | 9442875 | No |
| 1826 | 3468 | 1734.0 | 77.6 | 38.8 | Self-assembly at all scales. | George M Whitesides, Bartosz Grzybowski | Science | 2002 | 11923529 | Yes |
| 1827 | 6936 | 1734.0 | 236.3 | 59.1 | Near-optimal probabilistic RNA-seq quantification. | Nicolas L Bray, Harold Pimentel, Pall Melsted, Lior Pachter | Nat Biotechnol | 2016 | 27043002 | Yes |
| 1828 | 3467 | 1733.5 | 94.3 | 47.1 | Cloned glutamate receptors. | M Hollmann, S Heinemann | Annu Rev Neurosci | 1994 | 8210177 | No |
| 1829 | 1733 | 1733.0 | 53.3 | 53.3 | Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. | P A Bradford | Clin Microbiol Rev | 2001 | 11585791 | No |
| 1830 | 3465 | 1732.5 | 116.8 | 58.4 | Thermodynamics of protein association reactions: forces contributing to stability. | P D Ross, S Subramanian | Biochemistry | 1981 | 7248271 | Yes |
| 1831 | 1732 | 1732.0 | 31.8 | 31.8 | How eukaryotic transcriptional activators work. | M Ptashne | Nature | 1988 | 3050531 | No |
| 1832 | 1732 | 1732.0 | 51.0 | 51.0 | Signal transduction by reactive oxygen species. | Toren Finkel | J Cell Biol | 2011 | 21746850 | No |
| 1833 | 5196 | 1732.0 | 296.2 | 98.7 | MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization. | Kazutaka Katoh, John Rozewicki, Kazunori D Yamada | Brief Bioinform | 2019 | 28968734 | Yes |
| 1834 | 1731 | 1731.0 | 70.8 | 70.8 | Probiotics in man and animals. | R Fuller | J Appl Bacteriol | 1989 | 2666378 | No |
| 1835 | 1731 | 1731.0 | 39.5 | 39.5 | Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. | S L Friedman | J Biol Chem | 2000 | 10644669 | No |
| 1836 | 1730 | 1730.0 | 46.1 | 46.1 | The pathophysiology of tumor necrosis factors. | P Vassalli | Annu Rev Immunol | 1992 | 1590993 | No |
| 1837 | 1730 | 1730.0 | 66.2 | 66.2 | Cyclosporine. | B D Kahan | N Engl J Med | 1989 | 2687689 | No |
| 1838 | 1729 | 1729.0 | 41.6 | 41.6 | Neurotrophin-regulated signalling pathways. | Louis F Reichardt | Philos Trans R Soc Lond B Biol Sci | 2006 | 16939974 | No |
| 1839 | 1729 | 1729.0 | 58.5 | 58.5 | Phenylpropanoid biosynthesis. | Thomas Vogt | Mol Plant | 2010 | 20035037 | No |
| 1840 | 3457 | 1728.5 | 113.4 | 56.7 | Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. | G R Gibson, M B Roberfroid | J Nutr | 1995 | 7782892 | No |
| 1841 | 1728 | 1728.0 | 46.4 | 46.4 | Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. | E M Witkin | Bacteriol Rev | 1976 | 795416 | No |
| 1842 | 1728 | 1728.0 | 51.6 | 51.6 | The fetal and infant origins of adult disease. | D J Barker | BMJ | 1990 | 2252919 | No |
| 1843 | 5183 | 1727.7 | 115.5 | 38.5 | Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. | A Nicholls, K A Sharp, B Honig | Proteins | 1991 | 1758883 | Yes |
| 1844 | 3453 | 1726.5 | 77.1 | 38.5 | The DNA damage response: making it safe to play with knives. | Alberto Ciccia, Stephen J Elledge | Mol Cell | 2010 | 20965415 | No |
| 1845 | 1726 | 1726.0 | 46.4 | 46.4 | Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. | G C Walker | Microbiol Rev | 1984 | 6371470 | No |
| 1846 | 1725 | 1725.0 | 42.9 | 42.9 | The biology of incretin hormones. | Daniel J Drucker | Cell Metab | 2006 | 16517403 | No |
| 1847 | 1724 | 1724.0 | 0.0 | 0.0 | Cerebral blood flow and oxygen consumption in man. | N A Lassen | Physiol Rev | 1959 | 13645234 | Yes |
| 1848 | 5166 | 1722.0 | 216.1 | 72.0 | Some statistical methods useful in circulation research. | S Wallenstein, C L Zucker, J L Fleiss | Circ Res | 1980 | 7379260 | Yes |
| 1849 | 1722 | 1722.0 | 37.7 | 37.7 | Neuronal calcium signaling. | M J Berridge | Neuron | 1998 | 9697848 | No |
| 1850 | 1721 | 1721.0 | 39.6 | 39.6 | Pedigrees of some mutant strains of Escherichia coli K-12. | B J Bachmann | Bacteriol Rev | 1972 | 4568763 | No |
| 1851 | 1720 | 1720.0 | 91.3 | 91.3 | Cell death: a review of the major forms of apoptosis, necrosis and autophagy. | Mark S D'Arcy | Cell Biol Int | 2019 | 30958602 | No |
| 1852 | 1719 | 1719.0 | 43.6 | 43.6 | Recognition of errors in three-dimensional structures of proteins. | M J Sippl | Proteins | 1993 | 8108378 | Yes |
| 1853 | 1719 | 1719.0 | 37.4 | 37.4 | Topoisomerase I inhibitors: camptothecins and beyond. | Yves Pommier | Nat Rev Cancer | 2006 | 16990856 | No |
| 1854 | 5156 | 1718.7 | 106.0 | 35.3 | T-Coffee: A novel method for fast and accurate multiple sequence alignment. | C Notredame, D G Higgins, J Heringa | J Mol Biol | 2000 | 10964570 | Yes |
| 1855 | 5153 | 1717.7 | 191.4 | 63.8 | Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. | C J Caspersen, K E Powell, G M Christenson | Public Health Rep | 1985 | 3920711 | Yes |
| 1856 | 1717 | 1717.0 | 40.8 | 40.8 | The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. | R Ross | J Cell Biol | 1971 | 4327464 | Yes |
| 1857 | 1717 | 1717.0 | 34.4 | 34.4 | Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. | R K Jain | Nat Med | 2001 | 11533692 | No |
| 1858 | 1717 | 1717.0 | 67.2 | 67.2 | 1,500 scientists lift the lid on reproducibility. | Monya Baker | Nature | 2016 | 27225100 | No |
| 1859 | 1716 | 1716.0 | 50.7 | 50.7 | Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. | E N Bergman | Physiol Rev | 1990 | 2181501 | No |
| 1860 | 1716 | 1716.0 | 42.3 | 42.3 | Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. | S C Manolagas | Endocr Rev | 2000 | 10782361 | No |
| 1861 | 1715 | 1715.0 | 0.0 | 0.0 | Carbonic anhydrase: chemistry, physiology, and inhibition. | T H Maren | Physiol Rev | 1967 | 4964060 | No |
| 1862 | 1714 | 1714.0 | 64.5 | 64.5 | Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. | K O Fagerstrom | Addict Behav | 1978 | 735910 | Yes |
| 1863 | 1714 | 1714.0 | 92.0 | 92.0 | Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. | F E Zajac | Crit Rev Biomed Eng | 1989 | 2676342 | No |
| 1864 | 1714 | 1714.0 | 33.9 | 33.9 | Hox genes in vertebrate development. | R Krumlauf | Cell | 1994 | 7913880 | No |
| 1865 | 3428 | 1714.0 | 263.3 | 131.7 | Gut microbiota in human metabolic health and disease. | Yong Fan, Oluf Pedersen | Nat Rev Microbiol | 2021 | 32887946 | No |
| 1866 | 10279 | 1713.2 | 248.7 | 41.4 | Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. | Hadi Valadi, Karin Ekstrom, Apostolos Bossios, Margareta Sjostrand, James J Lee, Jan O Lotvall | Nat Cell Biol | 2007 | 17486113 | Yes |
| 1867 | 1713 | 1713.0 | 47.6 | 47.6 | Interoception: the sense of the physiological condition of the body. | A D Craig | Curr Opin Neurobiol | 2003 | 12965300 | No |
| 1868 | 1713 | 1713.0 | 0.0 | 0.0 | Application of a Theory of Enzyme Specificity to Protein Synthesis. | D E Koshland | Proc Natl Acad Sci U S A | 1958 | 16590179 | Yes |
| 1869 | 6848 | 1712.0 | 157.6 | 39.4 | Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. | E A Jaffe, R L Nachman, C G Becker, C R Minick | J Clin Invest | 1973 | 4355998 | Yes |
| 1870 | 1711 | 1711.0 | 80.6 | 80.6 | Chronic illness as biographical disruption. | M Bury | Sociol Health Illn | 1982 | 10260456 | Yes |
| 1871 | 3422 | 1711.0 | 71.1 | 35.5 | Upstream and downstream of mTOR. | Nissim Hay, Nahum Sonenberg | Genes Dev | 2004 | 15314020 | No |
| 1872 | 1711 | 1711.0 | 60.4 | 60.4 | Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. | George S Bloom | JAMA Neurol | 2014 | 24493463 | No |
| 1873 | 3421 | 1710.5 | 0.0 | 0.0 | A "Direct-Coloring" Thiocholine Method For Cholinesterases. | M J Karnovsky, L Roots | J Histochem Cytochem | 1964 | 14187330 | Yes |
| 1874 | 1710 | 1710.0 | 49.9 | 49.9 | Gold-catalyzed organic reactions. | A Stephen K Hashmi | Chem Rev | 2007 | 17580975 | Yes |
| 1875 | 3419 | 1709.5 | 102.9 | 51.5 | Diarrheagenic Escherichia coli. | J P Nataro, J B Kaper | Clin Microbiol Rev | 1998 | 9457432 | No |
| 1876 | 1709 | 1709.0 | 61.3 | 61.3 | Number of people with glaucoma worldwide. | H A Quigley | Br J Ophthalmol | 1996 | 8695555 | No |
| 1877 | 1709 | 1709.0 | 36.7 | 36.7 | Tumor metastasis: mechanistic insights and clinical challenges. | Patricia S Steeg | Nat Med | 2006 | 16892035 | No |
| 1878 | 1709 | 1709.0 | 43.5 | 43.5 | Reconciling the chemistry and biology of reactive oxygen species. | Christine C Winterbourn | Nat Chem Biol | 2008 | 18421291 | No |
| 1879 | 1708 | 1708.0 | 53.5 | 53.5 | Inflammation in atherosclerosis. | Peter Libby | Arterioscler Thromb Vasc Biol | 2012 | 22895665 | No |
| 1880 | 3414 | 1707.0 | 90.2 | 45.1 | The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. | A E Bolton, W M Hunter | Biochem J | 1973 | 4733239 | Yes |
| 1881 | 1707 | 1707.0 | 67.9 | 67.9 | An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. | J Kabat-Zinn | Gen Hosp Psychiatry | 1982 | 7042457 | Yes |
| 1882 | 3412 | 1706.0 | 86.4 | 43.2 | Protein structure prediction on the Web: a case study using the Phyre server. | Lawrence A Kelley, Michael J E Sternberg | Nat Protoc | 2009 | 19247286 | Yes |
| 1883 | 6823 | 1705.8 | 313.4 | 78.3 | Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. | Marie Verbanck, Chia-Yen Chen, Benjamin Neale, Ron Do | Nat Genet | 2018 | 29686387 | Yes |
| 1884 | 1705 | 1705.0 | 33.6 | 33.6 | Switching and signaling at the telomere. | E H Blackburn | Cell | 2001 | 11572773 | No |
| 1885 | 10226 | 1704.3 | 242.1 | 40.4 | Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. | D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire | Science | 1987 | 3798106 | Yes |
| 1886 | 1704 | 1704.0 | 0.0 | 0.0 | The statistical analysis of enzyme kinetic data. | W W Cleland | Adv Enzymol Relat Areas Mol Biol | 1967 | 4881884 | No |
| 1887 | 3408 | 1704.0 | 103.0 | 51.5 | Unified approach for molecular dynamics and density-functional theory. | R Car, M Parrinello | Phys Rev Lett | 1985 | 10032153 | Yes |
| 1888 | 3407 | 1703.5 | 81.4 | 40.7 | The human plasma proteome: history, character, and diagnostic prospects. | N Leigh Anderson, Norman G Anderson | Mol Cell Proteomics | 2002 | 12488461 | No |
| 1889 | 1703 | 1703.0 | 51.4 | 51.4 | Classification of inflammatory bowel disease. | J E Lennard-Jones | Scand J Gastroenterol Suppl | 1989 | 2617184 | Yes |
| 1890 | 3406 | 1703.0 | 81.9 | 41.0 | Human mesenchymal stem cells modulate allogeneic immune cell responses. | Sudeepta Aggarwal, Mark F Pittenger | Blood | 2005 | 15494428 | Yes |
| 1891 | 3406 | 1703.0 | 108.8 | 54.4 | Porosity of 3D biomaterial scaffolds and osteogenesis. | Vassilis Karageorgiou, David Kaplan | Biomaterials | 2005 | 15860204 | No |
| 1892 | 1702 | 1702.0 | 33.3 | 33.3 | Protein kinases--the major drug targets of the twenty-first century? | Philip Cohen | Nat Rev Drug Discov | 2002 | 12120282 | No |
| 1893 | 1701 | 1701.0 | 0.0 | 0.0 | Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. | E G Gray | J Anat | 1959 | 13829103 | Yes |
| 1894 | 3400 | 1700.0 | 82.5 | 41.2 | The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. | P Angel, M Karin | Biochim Biophys Acta | 1991 | 1751545 | No |
| 1895 | 1700 | 1700.0 | 45.7 | 45.7 | Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. | D A Dougherty | Science | 1996 | 8539615 | No |
| 1896 | 1699 | 1699.0 | 34.9 | 34.9 | Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. | D I Svergun | Biophys J | 1999 | 10354416 | Yes |
| 1897 | 1699 | 1699.0 | 41.9 | 41.9 | Upconversion and anti-Stokes processes with f and d ions in solids. | Francois Auzel | Chem Rev | 2004 | 14719973 | Yes |
| 1898 | 1699 | 1699.0 | 39.9 | 39.9 | Insulin and insulin-like growth factor signalling in neoplasia. | Michael Pollak | Nat Rev Cancer | 2008 | 19029956 | No |
| 1899 | 11891 | 1698.7 | 294.1 | 42.0 | Integrative genomics viewer. | James T Robinson, Helga Thorvaldsdottir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P Mesirov | Nat Biotechnol | 2011 | 21221095 | Yes |
| 1900 | 10189 | 1698.2 | 319.0 | 53.2 | The Molecular Signatures Database (MSigDB) hallmark gene set collection. | Arthur Liberzon, Chet Birger, Helga Thorvaldsdottir, Mahmoud Ghandi, Jill P Mesirov, Pablo Tamayo | Cell Syst | 2015 | 26771021 | Yes |
| 1901 | 3396 | 1698.0 | 116.9 | 58.5 | Role of free radicals and catalytic metal ions in human disease: an overview. | B Halliwell, J M Gutteridge | Methods Enzymol | 1990 | 2172697 | No |
| 1902 | 1698 | 1698.0 | 42.1 | 42.1 | NADPH oxidase: an update. | B M Babior | Blood | 1999 | 10029572 | No |
| 1903 | 3396 | 1698.0 | 75.9 | 38.0 | Microtubules as a target for anticancer drugs. | Mary Ann Jordan, Leslie Wilson | Nat Rev Cancer | 2004 | 15057285 | No |
| 1904 | 3395 | 1697.5 | 105.3 | 52.6 | What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. | J Zhang, K F Yu | JAMA | 1998 | 9832001 | Yes |
| 1905 | 1697 | 1697.0 | 48.4 | 48.4 | Subcutaneous and visceral adipose tissue: structural and functional differences. | M Mohsen Ibrahim | Obes Rev | 2010 | 19656312 | No |
| 1906 | 3393 | 1696.5 | 88.1 | 44.0 | Lipid rafts as a membrane-organizing principle. | Daniel Lingwood, Kai Simons | Science | 2010 | 20044567 | No |
| 1907 | 1696 | 1696.0 | 0.0 | 0.0 | A graphic method for the determination and presentation of binding parameters in a complex system. | H E Rosenthal | Anal Biochem | 1967 | 6048188 | Yes |
| 1908 | 3392 | 1696.0 | 122.7 | 61.4 | How useful is SBF in predicting in vivo bone bioactivity? | Tadashi Kokubo, Hiroaki Takadama | Biomaterials | 2006 | 16448693 | No |
| 1909 | 5088 | 1696.0 | 186.3 | 62.1 | CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. | Teresa C Horan, Mary Andrus, Margaret A Dudeck | Am J Infect Control | 2008 | 18538699 | No |
| 1910 | 3391 | 1695.5 | 113.1 | 56.5 | Physiological time-series analysis using approximate entropy and sample entropy. | J S Richman, J R Moorman | Am J Physiol Heart Circ Physiol | 2000 | 10843903 | Yes |
| 1911 | 1695 | 1695.0 | 43.0 | 43.0 | Use and misuse of the receiver operating characteristic curve in risk prediction. | Nancy R Cook | Circulation | 2007 | 17309939 | Yes |
| 1912 | 6777 | 1694.2 | 232.9 | 58.2 | The chemistry and applications of metal-organic frameworks. | Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M Yaghi | Science | 2013 | 23990564 | Yes |
| 1913 | 10164 | 1694.0 | 358.8 | 59.8 | Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. | L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum | Anal Biochem | 1982 | 7181105 | Yes |
| 1914 | 1694 | 1694.0 | 57.2 | 57.2 | The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. | J L Cummings | Neurology | 1997 | 9153155 | No |
| 1915 | 1693 | 1693.0 | 0.0 | 0.0 | Plastic Embedding Mixtures For Use In Electron Microscopy. | H H Mollenhauer | Stain Technol | 1964 | 14127791 | Yes |
| 1916 | 1693 | 1693.0 | 55.6 | 55.6 | ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps. | Tristan Ian Croll | Acta Crystallogr D Struct Biol | 2018 | 29872003 | Yes |
| 1917 | 1692 | 1692.0 | 47.1 | 47.1 | Integrins. | E Ruoslahti | J Clin Invest | 1991 | 1985087 | No |
| 1918 | 1692 | 1692.0 | 56.4 | 56.4 | Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. | L Bravo | Nutr Rev | 1998 | 9838798 | No |
| 1919 | 5076 | 1692.0 | 142.3 | 47.4 | Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. | B Fischl, M I Sereno, A M Dale | Neuroimage | 1999 | 9931269 | Yes |
| 1920 | 3383 | 1691.5 | 98.4 | 49.2 | Biochemistry of multidrug resistance mediated by the multidrug transporter. | M M Gottesman, I Pastan | Annu Rev Biochem | 1993 | 8102521 | No |
| 1921 | 1691 | 1691.0 | 29.8 | 29.8 | RNA-dependent DNA polymerase in virions of RNA tumour viruses. | D Baltimore | Nature | 1970 | 4316300 | Yes |
| 1922 | 1691 | 1691.0 | 54.8 | 54.8 | Aging, natural death, and the compression of morbidity. | J F Fries | N Engl J Med | 1980 | 7383070 | Yes |
| 1923 | 1690 | 1690.0 | 45.7 | 45.7 | Alpha-crystallin can function as a molecular chaperone. | J Horwitz | Proc Natl Acad Sci U S A | 1992 | 1438232 | Yes |
| 1924 | 1690 | 1690.0 | 55.5 | 55.5 | Metallothionein. | D H Hamer | Annu Rev Biochem | 1986 | 3527054 | No |
| 1925 | 1690 | 1690.0 | 60.2 | 60.2 | Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. | A H Conney | Cancer Res | 1982 | 6814745 | No |
| 1926 | 1690 | 1690.0 | 49.9 | 49.9 | Nanobodies: natural single-domain antibodies. | Serge Muyldermans | Annu Rev Biochem | 2013 | 23495938 | No |
| 1927 | 1689 | 1689.0 | 41.7 | 41.7 | The molecular genetics of cancer. | J M Bishop | Science | 1987 | 3541204 | No |
| 1928 | 5066 | 1688.7 | 143.9 | 48.0 | Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. | M Hasegawa, H Kishino, T Yano | J Mol Evol | 1985 | 3934395 | Yes |
| 1929 | 1688 | 1688.0 | 76.0 | 76.0 | Mood and memory. | G H Bower | Am Psychol | 1981 | 7224324 | Yes |
| 1930 | 1688 | 1688.0 | 46.0 | 46.0 | Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. | M J Meaney | Annu Rev Neurosci | 2001 | 11520931 | No |
| 1931 | 1687 | 1687.0 | 44.6 | 44.6 | Fast and robust fixed-point algorithms for independent component analysis. | A Hyvarinen | IEEE Trans Neural Netw | 1999 | 18252563 | Yes |
| 1932 | 3374 | 1687.0 | 116.2 | 58.1 | Factors affecting wound healing. | S Guo, L A Dipietro | J Dent Res | 2010 | 20139336 | No |
| 1933 | 1685 | 1685.0 | 38.0 | 38.0 | Mechanisms of bone metastasis. | G David Roodman | N Engl J Med | 2004 | 15084698 | No |
| 1934 | 6738 | 1684.5 | 169.1 | 42.3 | Most mammalian mRNAs are conserved targets of microRNAs. | Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel | Genome Res | 2009 | 18955434 | Yes |
| 1935 | 3367 | 1683.5 | 109.3 | 54.6 | An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. | O Johnell, J A Kanis | Osteoporos Int | 2006 | 16983459 | Yes |
| 1936 | 1683 | 1683.0 | 66.5 | 66.5 | A structured interview guide for the Hamilton Depression Rating Scale. | J B Williams | Arch Gen Psychiatry | 1988 | 3395203 | Yes |
| 1937 | 1683 | 1683.0 | 39.7 | 39.7 | The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. | D M Kingsley | Genes Dev | 1994 | 8299934 | No |
| 1938 | 1683 | 1683.0 | 41.2 | 41.2 | A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. | D A Gewirtz | Biochem Pharmacol | 1999 | 10075079 | No |
| 1939 | 1683 | 1683.0 | 34.4 | 34.4 | Macromolecular crowding: obvious but underappreciated. | R J Ellis | Trends Biochem Sci | 2001 | 11590012 | No |
| 1940 | 1682 | 1682.0 | 32.7 | 32.7 | Cell cycle checkpoints: preventing an identity crisis. | S J Elledge | Science | 1996 | 8939848 | No |
| 1941 | 1682 | 1682.0 | 0.0 | 0.0 | Chromatographic Separation Of Human Brain Gangliosides. | L Svennerholm | J Neurochem | 1963 | 14066623 | Yes |
| 1942 | 3363 | 1681.5 | 127.2 | 63.6 | Macrophages in Tissue Repair, Regeneration, and Fibrosis. | Thomas A Wynn, Kevin M Vannella | Immunity | 2016 | 26982353 | No |
| 1943 | 1681 | 1681.0 | 56.9 | 56.9 | Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. | J A Miller | Cancer Res | 1970 | 4915745 | No |
| 1944 | 5042 | 1680.7 | 114.6 | 38.2 | Osteoclast differentiation and activation. | William J Boyle, W Scott Simonet, David L Lacey | Nature | 2003 | 12748652 | No |
| 1945 | 5037 | 1679.0 | 146.6 | 48.9 | How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. | R M Sapolsky, L M Romero, A U Munck | Endocr Rev | 2000 | 10696570 | No |
| 1946 | 3358 | 1679.0 | 106.4 | 53.2 | Palladium-catalyzed ligand-directed C-H functionalization reactions. | Thomas W Lyons, Melanie S Sanford | Chem Rev | 2010 | 20078038 | No |
| 1947 | 3355 | 1677.5 | 164.2 | 82.1 | Breast Cancer Treatment: A Review. | Adrienne G Waks, Eric P Winer | JAMA | 2019 | 30667505 | No |
| 1948 | 3354 | 1677.0 | 125.4 | 62.7 | Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. | D B Dill, D L Costill | J Appl Physiol | 1974 | 4850854 | Yes |
| 1949 | 1676 | 1676.0 | 36.5 | 36.5 | Sustainable hydrogen production. | John A Turner | Science | 2004 | 15310892 | Yes |
| 1950 | 1675 | 1675.0 | 54.2 | 54.2 | Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). | G G Glenner | N Engl J Med | 1980 | 6154243 | No |
| 1951 | 5018 | 1672.7 | 123.2 | 41.1 | Two-photon laser scanning fluorescence microscopy. | W Denk, J H Strickler, W W Webb | Science | 1990 | 2321027 | Yes |
| 1952 | 1672 | 1672.0 | 56.0 | 56.0 | Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). | M N Marsh | Gastroenterology | 1992 | 1727768 | No |
| 1953 | 1671 | 1671.0 | 68.3 | 68.3 | Social phobia. | M R Liebowitz | Mod Probl Pharmacopsychiatry | 1987 | 2885745 | Yes |
| 1954 | 1671 | 1671.0 | 44.1 | 44.1 | Neurotrophins and neuronal plasticity. | H Thoenen | Science | 1995 | 7570017 | No |
| 1955 | 1671 | 1671.0 | 62.8 | 62.8 | Microtiter dish biofilm formation assay. | George A O'Toole | J Vis Exp | 2011 | 21307833 | Yes |
| 1956 | 3340 | 1670.0 | 68.9 | 34.5 | NF-kappaB regulation in the immune system. | Qiutang Li, Inder M Verma | Nat Rev Immunol | 2002 | 12360211 | No |
| 1957 | 1669 | 1669.0 | 0.0 | 0.0 | Method for the determination of hexosamines in tissues. | N F Boas | J Biol Chem | 1953 | 13117829 | Yes |
| 1958 | 1669 | 1669.0 | 52.6 | 52.6 | Synopsis of some recent tactical application of bioisosteres in drug design. | Nicholas A Meanwell | J Med Chem | 2011 | 21413808 | Yes |
| 1959 | 3337 | 1668.5 | 0.0 | 0.0 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. | T Omura, R Sato | J Biol Chem | 1964 | 14209972 | Yes |
| 1960 | 1668 | 1668.0 | 33.2 | 33.2 | The microRNA Registry. | Sam Griffiths-Jones | Nucleic Acids Res | 2004 | 14681370 | Yes |
| 1961 | 3336 | 1668.0 | 73.5 | 36.8 | Cancer metastasis: building a framework. | Gaorav P Gupta, Joan Massague | Cell | 2006 | 17110329 | No |
| 1962 | 1667 | 1667.0 | 47.0 | 47.0 | Aspergillus fumigatus and aspergillosis. | J P Latge | Clin Microbiol Rev | 1999 | 10194462 | No |
| 1963 | 3334 | 1667.0 | 80.0 | 40.0 | NF-kappaB: a key role in inflammatory diseases. | P P Tak, G S Firestein | J Clin Invest | 2001 | 11134171 | No |
| 1964 | 1667 | 1667.0 | 40.4 | 40.4 | Hypertrophic cardiomyopathy: a systematic review. | Barry J Maron | JAMA | 2002 | 11886323 | Yes |
| 1965 | 1665 | 1665.0 | 62.2 | 62.2 | Frontal-subcortical circuits and human behavior. | J L Cummings | Arch Neurol | 1993 | 8352676 | No |
| 1966 | 3330 | 1665.0 | 80.7 | 40.4 | Malignant gliomas in adults. | Patrick Y Wen, Santosh Kesari | N Engl J Med | 2008 | 18669428 | No |
| 1967 | 8325 | 1665.0 | 329.6 | 65.9 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | Int J Surg | 2010 | 20171303 | No |
| 1968 | 13315 | 1664.4 | 353.9 | 44.2 | Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. | William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan, | N Engl J Med | 2002 | 11832527 | Yes |
| 1969 | 1664 | 1664.0 | 57.6 | 57.6 | Archaea in coastal marine environments. | E F DeLong | Proc Natl Acad Sci U S A | 1992 | 1608980 | Yes |
| 1970 | 1663 | 1663.0 | 53.7 | 53.7 | The role of the amygdala in fear and anxiety. | M Davis | Annu Rev Neurosci | 1992 | 1575447 | No |
| 1971 | 1663 | 1663.0 | 63.5 | 63.5 | The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. | Poul Erik Petersen | Community Dent Oral Epidemiol | 2003 | 15015736 | Yes |
| 1972 | 1663 | 1663.0 | 56.8 | 56.8 | The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. | Eleonore Frohlich | Int J Nanomedicine | 2012 | 23144561 | No |
| 1973 | 3325 | 1662.5 | 0.0 | 0.0 | Method for the isolation of intact islets of Langerhans from the rat pancreas. | P E Lacy, M Kostianovsky | Diabetes | 1967 | 5333500 | Yes |
| 1974 | 3325 | 1662.5 | 73.7 | 36.9 | Protein structure comparison by alignment of distance matrices. | L Holm, C Sander | J Mol Biol | 1993 | 8377180 | Yes |
| 1975 | 3325 | 1662.5 | 70.9 | 35.5 | Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. | E Krissinel, K Henrick | Acta Crystallogr D Biol Crystallogr | 2004 | 15572779 | Yes |
| 1976 | 6649 | 1662.2 | 346.6 | 86.7 | Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads. | Ryan R Wick, Louise M Judd, Claire L Gorrie, Kathryn E Holt | PLoS Comput Biol | 2017 | 28594827 | Yes |
| 1977 | 1662 | 1662.0 | 47.0 | 47.0 | Sarcopenia: origins and clinical relevance. | I H Rosenberg | J Nutr | 1997 | 9164280 | No |
| 1978 | 1662 | 1662.0 | 41.3 | 41.3 | Getting formal with dopamine and reward. | Wolfram Schultz | Neuron | 2002 | 12383780 | No |
| 1979 | 1661 | 1661.0 | 71.5 | 71.5 | Drugs which inhibit prostaglandin biosynthesis. | R J Flower | Pharmacol Rev | 1974 | 4208101 | Yes |
| 1980 | 1661 | 1661.0 | 42.0 | 42.0 | Myeloperoxidase: friend and foe. | Seymour J Klebanoff | J Leukoc Biol | 2005 | 15689384 | No |
| 1981 | 1661 | 1661.0 | 49.8 | 49.8 | Bioactive microbial metabolites. | Janos Berdy | J Antibiot (Tokyo) | 2005 | 15813176 | No |
| 1982 | 3321 | 1660.5 | 97.2 | 48.6 | A fast, lock-free approach for efficient parallel counting of occurrences of k-mers. | Guillaume Marcais, Carl Kingsford | Bioinformatics | 2011 | 21217122 | Yes |
| 1983 | 1660 | 1660.0 | 0.0 | 0.0 | An improved procedure for serum creatine phosphokinase determination. | S B Rosalki | J Lab Clin Med | 1967 | 4381359 | Yes |
| 1984 | 1660 | 1660.0 | 0.0 | 0.0 | The theory and applications of the exchange of inert gas at the lungs and tissues. | S S Kety | Pharmacol Rev | 1951 | 14833874 | Yes |
| 1985 | 1660 | 1660.0 | 34.3 | 34.3 | The Buccaneer software for automated model building. 1. Tracing protein chains. | Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2006 | 16929101 | Yes |
| 1986 | 4978 | 1659.3 | 164.9 | 55.0 | Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. | Marina Colombo, Graca Raposo, Clotilde Thery | Annu Rev Cell Dev Biol | 2014 | 25288114 | No |
| 1987 | 6637 | 1659.2 | 155.4 | 38.9 | Use of T7 RNA polymerase to direct expression of cloned genes. | F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff | Methods Enzymol | 1990 | 2199796 | Yes |
| 1988 | 3318 | 1659.0 | 78.6 | 39.3 | A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. | L Buck, R Axel | Cell | 1991 | 1840504 | Yes |
| 1989 | 3318 | 1659.0 | 63.0 | 31.5 | The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. | Michael H Glickman, Aaron Ciechanover | Physiol Rev | 2002 | 11917093 | No |
| 1990 | 1659 | 1659.0 | 82.9 | 82.9 | Non-alcoholic fatty liver disease - A global public health perspective. | Zobair M Younossi | J Hepatol | 2019 | 30414863 | No |
| 1991 | 3317 | 1658.5 | 112.6 | 56.3 | Mediation in experimental and nonexperimental studies: new procedures and recommendations. | Patrick E Shrout, Niall Bolger | Psychol Methods | 2002 | 12530702 | Yes |
| 1992 | 3316 | 1658.0 | 119.5 | 59.8 | The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. | Julie D Henry, John R Crawford | Br J Clin Psychol | 2005 | 16004657 | Yes |
| 1993 | 3315 | 1657.5 | 84.2 | 42.1 | Steatohepatitis: a tale of two "hits"? | C P Day, O F James | Gastroenterology | 1998 | 9547102 | No |
| 1994 | 3314 | 1657.0 | 80.5 | 40.2 | Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. | M Grunstein, D S Hogness | Proc Natl Acad Sci U S A | 1975 | 1105573 | Yes |
| 1995 | 1657 | 1657.0 | 45.0 | 45.0 | The corticosteroid receptor hypothesis of depression. | F Holsboer | Neuropsychopharmacology | 2000 | 11027914 | No |
| 1996 | 1657 | 1657.0 | 48.5 | 48.5 | n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. | Philip C Calder | Am J Clin Nutr | 2006 | 16841861 | No |
| 1997 | 1657 | 1657.0 | 50.5 | 50.5 | The role of autophagy in neurodegenerative disease. | Ralph A Nixon | Nat Med | 2013 | 23921753 | No |
| 1998 | 1656 | 1656.0 | 38.2 | 38.2 | From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. | W A Catterall | Neuron | 2000 | 10798388 | No |
| 1999 | 3312 | 1656.0 | 89.8 | 44.9 | Materials for electrochemical capacitors. | Patrice Simon, Yury Gogotsi | Nat Mater | 2008 | 18956000 | Yes |
| 2000 | 3312 | 1656.0 | 114.5 | 57.2 | A new initiative on precision medicine. | Francis S Collins, Harold Varmus | N Engl J Med | 2015 | 25635347 | Yes |
| 2001 | 3310 | 1655.0 | 84.8 | 42.4 | Alternative activation of macrophages: mechanism and functions. | Siamon Gordon, Fernando O Martinez | Immunity | 2010 | 20510870 | No |
| 2002 | 1654 | 1654.0 | 63.9 | 63.9 | SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. | B P O'Connor | Behav Res Methods Instrum Comput | 2000 | 11029811 | Yes |
| 2003 | 3308 | 1654.0 | 92.2 | 46.1 | A globally coherent fingerprint of climate change impacts across natural systems. | Camille Parmesan, Gary Yohe | Nature | 2003 | 12511946 | Yes |
| 2004 | 1654 | 1654.0 | 0.0 | 0.0 | Structural considerations in the interaction of DNA and acridines. | L S Lerman | J Mol Biol | 1961 | 13761054 | Yes |
| 2005 | 8270 | 1654.0 | 432.8 | 86.6 | Standards for reporting qualitative research: a synthesis of recommendations. | Bridget C O'Brien, Ilene B Harris, Thomas J Beckman, Darcy A Reed, David A Cook | Acad Med | 2014 | 24979285 | Yes |
| 2006 | 1653 | 1653.0 | 32.2 | 32.2 | Protein degradation and protection against misfolded or damaged proteins. | Alfred L Goldberg | Nature | 2003 | 14685250 | No |
| 2007 | 1653 | 1653.0 | 56.2 | 56.2 | Evaluating the quality of medical care. 1966. | Avedis Donabedian | Milbank Q | 2005 | 16279964 | No |
| 2008 | 3304 | 1652.0 | 100.1 | 50.0 | Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. | M Karas, F Hillenkamp | Anal Chem | 1988 | 3239801 | Yes |
| 2009 | 4956 | 1652.0 | 101.9 | 34.0 | The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. | Fabio Martinon, Kimberly Burns, Jurg Tschopp | Mol Cell | 2002 | 12191486 | Yes |
| 2010 | 4955 | 1651.7 | 0.0 | 0.0 | Improved method for the determination of blood glutathione. | E Beutler, O Duron, B M Kelly | J Lab Clin Med | 1963 | 13967893 | Yes |
| 2011 | 3303 | 1651.5 | 68.2 | 34.1 | Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. | Joshua E Elias, Steven P Gygi | Nat Methods | 2007 | 17327847 | Yes |
| 2012 | 1651 | 1651.0 | 36.4 | 36.4 | Fluorescence energy transfer as a spectroscopic ruler. | L Stryer | Annu Rev Biochem | 1978 | 354506 | No |
| 2013 | 1651 | 1651.0 | 75.5 | 75.5 | The contribution of low birth weight to infant mortality and childhood morbidity. | M C McCormick | N Engl J Med | 1985 | 3880598 | No |
| 2014 | 3301 | 1650.5 | 153.9 | 77.0 | A scaled version of the General Health Questionnaire. | D P Goldberg, V F Hillier | Psychol Med | 1979 | 424481 | Yes |
| 2015 | 1650 | 1650.0 | 55.3 | 55.3 | Interhemispheric differences in the localization of psychological processes in man. | B Milner | Br Med Bull | 1971 | 4937273 | No |
| 2016 | 1650 | 1650.0 | 36.1 | 36.1 | Bone morphogenetic proteins: multifunctional regulators of vertebrate development. | B L Hogan | Genes Dev | 1996 | 8682290 | No |
| 2017 | 1650 | 1650.0 | 58.0 | 58.0 | Phase retrieval algorithms: a comparison. | J R Fienup | Appl Opt | 1982 | 20396114 | Yes |
| 2018 | 4949 | 1649.7 | 317.9 | 106.0 | Correlation Coefficients: Appropriate Use and Interpretation. | Patrick Schober, Christa Boer, Lothar A Schwarte | Anesth Analg | 2018 | 29481436 | No |
| 2019 | 1649 | 1649.0 | 34.3 | 34.3 | Structural features in eukaryotic mRNAs that modulate the initiation of translation. | M Kozak | J Biol Chem | 1991 | 1939050 | No |
| 2020 | 3298 | 1649.0 | 72.4 | 36.2 | Coordination of circadian timing in mammals. | Steven M Reppert, David R Weaver | Nature | 2002 | 12198538 | No |
| 2021 | 1648 | 1648.0 | 28.0 | 28.0 | Selforganization of matter and the evolution of biological macromolecules. | M Eigen | Naturwissenschaften | 1971 | 4942363 | No |
| 2022 | 1648 | 1648.0 | 29.2 | 29.2 | Cell cycle checkpoint signaling through the ATM and ATR kinases. | R T Abraham | Genes Dev | 2001 | 11544175 | No |
| 2023 | 1648 | 1648.0 | 0.0 | 0.0 | The generalisation of student's problems when several different population variances are involved. | B L Welch | Biometrika | 1947 | 20287819 | Yes |
| 2024 | 1647 | 1647.0 | 42.1 | 42.1 | The 'effective number of codons' used in a gene. | F Wright | Gene | 1990 | 2110097 | Yes |
| 2025 | 3294 | 1647.0 | 108.2 | 54.1 | Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. | Sarah E Barlow, | Pediatrics | 2007 | 18055651 | Yes |
| 2026 | 3294 | 1647.0 | 130.1 | 65.0 | Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. | Peter C Austin, Elizabeth A Stuart | Stat Med | 2015 | 26238958 | Yes |
| 2027 | 1646 | 1646.0 | 42.1 | 42.1 | Inflammatory bowel disease: etiology and pathogenesis. | C Fiocchi | Gastroenterology | 1998 | 9649475 | No |
| 2028 | 1646 | 1646.0 | 41.4 | 41.4 | The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. | H Maeda | Adv Enzyme Regul | 2001 | 11384745 | No |
| 2029 | 6583 | 1645.8 | 298.0 | 74.5 | Progressive statistics for studies in sports medicine and exercise science. | William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri Hanin | Med Sci Sports Exerc | 2009 | 19092709 | No |
| 2030 | 11520 | 1645.7 | 395.9 | 56.6 | Metagenomic biomarker discovery and explanation. | Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis Huttenhower | Genome Biol | 2011 | 21702898 | Yes |
| 2031 | 1645 | 1645.0 | 31.5 | 31.5 | Immunosuppressive networks in the tumour environment and their therapeutic relevance. | Weiping Zou | Nat Rev Cancer | 2005 | 15776005 | No |
| 2032 | 1644 | 1644.0 | 42.0 | 42.0 | Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. | C A Barnes | J Comp Physiol Psychol | 1979 | 221551 | Yes |
| 2033 | 1644 | 1644.0 | 44.9 | 44.9 | Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. | B Hille | J Gen Physiol | 1977 | 300786 | Yes |
| 2034 | 1644 | 1644.0 | 50.4 | 50.4 | Extracellular ATP: effects, sources and fate. | J L Gordon | Biochem J | 1986 | 3006665 | No |
| 2035 | 3288 | 1644.0 | 87.8 | 43.9 | Genome regulation by long noncoding RNAs. | John L Rinn, Howard Y Chang | Annu Rev Biochem | 2012 | 22663078 | No |
| 2036 | 3287 | 1643.5 | 109.2 | 54.6 | MissForest--non-parametric missing value imputation for mixed-type data. | Daniel J Stekhoven, Peter Buhlmann | Bioinformatics | 2012 | 22039212 | Yes |
| 2037 | 3286 | 1643.0 | 87.3 | 43.6 | Abdominal obesity and metabolic syndrome. | Jean-Pierre Despres, Isabelle Lemieux | Nature | 2006 | 17167477 | No |
| 2038 | 3285 | 1642.5 | 83.7 | 41.9 | Molecular replacement with MOLREP. | Alexei Vagin, Alexei Teplyakov | Acta Crystallogr D Biol Crystallogr | 2010 | 20057045 | Yes |
| 2039 | 1642 | 1642.0 | 46.9 | 46.9 | Turnover of inositol phospholipids and signal transduction. | Y Nishizuka | Science | 1984 | 6147898 | No |
| 2040 | 1642 | 1642.0 | 31.0 | 31.0 | Vienna RNA secondary structure server. | Ivo L Hofacker | Nucleic Acids Res | 2003 | 12824340 | Yes |
| 2041 | 1642 | 1642.0 | 65.6 | 65.6 | What is self-rated health and why does it predict mortality? Towards a unified conceptual model. | Marja Jylha | Soc Sci Med | 2009 | 19520474 | Yes |
| 2042 | 1641 | 1641.0 | 45.1 | 45.1 | Precision mapping of quantitative trait loci. | Z B Zeng | Genetics | 1994 | 8013918 | Yes |
| 2043 | 1641 | 1641.0 | 30.5 | 30.5 | Maximum-likelihood density modification. | T C Terwilliger | Acta Crystallogr D Biol Crystallogr | 2000 | 10944333 | Yes |
| 2044 | 6563 | 1640.8 | 166.1 | 41.5 | Universal sample preparation method for proteome analysis. | Jacek R Wisniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias Mann | Nat Methods | 2009 | 19377485 | Yes |
| 2045 | 3281 | 1640.5 | 70.7 | 35.4 | Signaling to NF-kappaB. | Matthew S Hayden, Sankar Ghosh | Genes Dev | 2004 | 15371334 | No |
| 2046 | 1640 | 1640.0 | 32.3 | 32.3 | Regulatory T cells, tumour immunity and immunotherapy. | Weiping Zou | Nat Rev Immunol | 2006 | 16557261 | No |
| 2047 | 9839 | 1639.8 | 295.1 | 49.2 | TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. | Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg | Genome Biol | 2013 | 23618408 | Yes |
| 2048 | 4919 | 1639.7 | 151.0 | 50.3 | The fusiform face area: a module in human extrastriate cortex specialized for face perception. | N Kanwisher, J McDermott, M M Chun | J Neurosci | 1997 | 9151747 | Yes |
| 2049 | 1639 | 1639.0 | 37.7 | 37.7 | Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. | G L Semenza | Annu Rev Cell Dev Biol | 1999 | 10611972 | No |
| 2050 | 1639 | 1639.0 | 32.1 | 32.1 | Intrinsically unstructured proteins. | Peter Tompa | Trends Biochem Sci | 2002 | 12368089 | No |
| 2051 | 1638 | 1638.0 | 55.3 | 55.3 | Cellular defenses against damage from reactive oxygen species. | B P Yu | Physiol Rev | 1994 | 8295932 | No |
| 2052 | 1638 | 1638.0 | 39.1 | 39.1 | Thiazolidinediones. | Hannele Yki-Jarvinen | N Engl J Med | 2004 | 15356308 | No |
| 2053 | 1637 | 1637.0 | 74.1 | 74.1 | Neurogenetic adaptive mechanisms in alcoholism. | C R Cloninger | Science | 1987 | 2882604 | Yes |
| 2054 | 1637 | 1637.0 | 85.4 | 85.4 | Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. | C S Neer | J Bone Joint Surg Am | 1972 | 5054450 | Yes |
| 2055 | 1637 | 1637.0 | 27.8 | 27.8 | Neuronal specification in the spinal cord: inductive signals and transcriptional codes. | T M Jessell | Nat Rev Genet | 2000 | 11262869 | No |
| 2056 | 1637 | 1637.0 | 0.0 | 0.0 | Discharge patterns and functional organization of mammalian retina. | S W Kuffler | J Neurophysiol | 1953 | 13035466 | Yes |
| 2057 | 1637 | 1637.0 | 58.3 | 58.3 | Glutathione synthesis. | Shelly C Lu | Biochim Biophys Acta | 2013 | 22995213 | No |
| 2058 | 1636 | 1636.0 | 0.0 | 0.0 | A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. | D Mattingly | J Clin Pathol | 1962 | 14471419 | Yes |
| 2059 | 3272 | 1636.0 | 73.0 | 36.5 | Complex networks orchestrate epithelial-mesenchymal transitions. | Jean Paul Thiery, Jonathan P Sleeman | Nat Rev Mol Cell Biol | 2006 | 16493418 | No |
| 2060 | 1636 | 1636.0 | 36.1 | 36.1 | DNA damage, aging, and cancer. | Jan H J Hoeijmakers | N Engl J Med | 2009 | 19812404 | No |
| 2061 | 3268 | 1634.0 | 79.1 | 39.5 | Rapid and sensitive protein similarity searches. | D J Lipman, W R Pearson | Science | 1985 | 2983426 | Yes |
| 2062 | 3268 | 1634.0 | 86.4 | 43.2 | Obesity. | David W Haslam, W Philip T James | Lancet | 2005 | 16198769 | No |
| 2063 | 1633 | 1633.0 | 51.4 | 51.4 | Which elements are excited in electrical stimulation of mammalian central nervous system: a review. | J B Ranck | Brain Res | 1975 | 1102064 | No |
| 2064 | 1633 | 1633.0 | 52.4 | 52.4 | Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. | D W Choi | Trends Neurosci | 1988 | 2469166 | No |
| 2065 | 1633 | 1633.0 | 74.9 | 74.9 | Measurement of health state utilities for economic appraisal. | G W Torrance | J Health Econ | 1986 | 10311607 | No |
| 2066 | 3266 | 1633.0 | 0.0 | 0.0 | Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. | J Marmur, P Doty | J Mol Biol | 1962 | 14470099 | Yes |
| 2067 | 3266 | 1633.0 | 136.9 | 68.5 | The content validity index: are you sure you know what's being reported? Critique and recommendations. | Denise F Polit, Cheryl Tatano Beck | Res Nurs Health | 2006 | 16977646 | Yes |
| 2068 | 1632 | 1632.0 | 33.9 | 33.9 | RNA silencing in plants. | David Baulcombe | Nature | 2004 | 15372043 | No |
| 2069 | 3264 | 1632.0 | 96.2 | 48.1 | Tumor-associated macrophages: from mechanisms to therapy. | Roy Noy, Jeffrey W Pollard | Immunity | 2014 | 25035953 | No |
| 2070 | 13054 | 1631.8 | 363.0 | 45.4 | Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. | N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot | Neuroimage | 2002 | 11771995 | Yes |
| 2071 | 1630 | 1630.0 | 47.5 | 47.5 | The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. | R R Llinas | Science | 1988 | 3059497 | No |
| 2072 | 1629 | 1629.0 | 47.7 | 47.7 | Ionic dependence of glutamate neurotoxicity. | D W Choi | J Neurosci | 1987 | 2880938 | Yes |
| 2073 | 1629 | 1629.0 | 37.6 | 37.6 | Measuring information transfer | T Schreiber | Phys Rev Lett | 2000 | 10991308 | Yes |
| 2074 | 1629 | 1629.0 | 39.8 | 39.8 | Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. | Christopher Paul Wild | Cancer Epidemiol Biomarkers Prev | 2005 | 16103423 | No |
| 2075 | 4885 | 1628.3 | 128.6 | 42.9 | The metabolic syndrome. | Robert H Eckel, Scott M Grundy, Paul Z Zimmet | Lancet | 2005 | 15836891 | No |
| 2076 | 1627 | 1627.0 | 51.0 | 51.0 | The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. | Artemis P Simopoulos | Exp Biol Med (Maywood) | 2008 | 18408140 | No |
| 2077 | 3252 | 1626.0 | 55.9 | 27.9 | Mutations affecting segment number and polarity in Drosophila. | C Nusslein-Volhard, E Wieschaus | Nature | 1980 | 6776413 | Yes |
| 2078 | 3252 | 1626.0 | 83.1 | 41.5 | Dali server: conservation mapping in 3D. | Liisa Holm, Paivi Rosenstrom | Nucleic Acids Res | 2010 | 20457744 | Yes |
| 2079 | 1626 | 1626.0 | 91.6 | 91.6 | Head and Neck Cancer. | Laura Q M Chow | N Engl J Med | 2020 | 31893516 | No |
| 2080 | 1625 | 1625.0 | 37.3 | 37.3 | Hyaluronan: from extracellular glue to pericellular cue. | Bryan P Toole | Nat Rev Cancer | 2004 | 15229478 | No |
| 2081 | 1625 | 1625.0 | 45.9 | 45.9 | Diversity in tropical rain forests and coral reefs. | J H Connell | Science | 1978 | 17840770 | Yes |
| 2082 | 1624 | 1624.0 | 49.5 | 49.5 | Metalloproteinases and their inhibitors in matrix remodeling. | L M Matrisian | Trends Genet | 1990 | 2132731 | No |
| 2083 | 1624 | 1624.0 | 59.1 | 59.1 | Cell damage in the brain: a speculative synthesis. | B K Siesjo | J Cereb Blood Flow Metab | 1981 | 6276420 | No |
| 2084 | 1623 | 1623.0 | 37.8 | 37.8 | Ordered porous materials for emerging applications. | Mark E Davis | Nature | 2002 | 12075343 | No |
| 2085 | 1623 | 1623.0 | 40.7 | 40.7 | Mitochondrial fusion and fission in cell life and death. | Benedikt Westermann | Nat Rev Mol Cell Biol | 2010 | 21102612 | No |
| 2086 | 1623 | 1623.0 | 79.4 | 79.4 | Statistical notes for clinical researchers: assessing normal distribution (2) using skewness and kurtosis. | Hae-Young Kim | Restor Dent Endod | 2013 | 23495371 | Yes |
| 2087 | 4868 | 1622.7 | 101.2 | 33.7 | Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). | Michael J Rust, Mark Bates, Xiaowei Zhuang | Nat Methods | 2006 | 16896339 | Yes |
| 2088 | 3245 | 1622.5 | 69.1 | 34.5 | The Bcl2 family: regulators of the cellular life-or-death switch. | Suzanne Cory, Jerry M Adams | Nat Rev Cancer | 2002 | 12209154 | No |
| 2089 | 3245 | 1622.5 | 60.6 | 30.3 | Cellular motility driven by assembly and disassembly of actin filaments. | Thomas D Pollard, Gary G Borisy | Cell | 2003 | 12600310 | No |
| 2090 | 9735 | 1622.5 | 351.7 | 58.6 | StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. | Mihaela Pertea, Geo M Pertea, Corina M Antonescu, Tsung-Cheng Chang, Joshua T Mendell, Steven L Salzberg | Nat Biotechnol | 2015 | 25690850 | Yes |
| 2091 | 1622 | 1622.0 | 42.3 | 42.3 | Molecular biology of prion diseases. | S B Prusiner | Science | 1991 | 1675487 | No |
| 2092 | 3244 | 1622.0 | 64.9 | 32.5 | Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. | M E Greenberg, E B Ziff | Nature | 1984 | 6090941 | Yes |
| 2093 | 4866 | 1622.0 | 131.5 | 43.8 | Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. | Earl S Ford, Wayne H Giles, William H Dietz | JAMA | 2002 | 11790215 | Yes |
| 2094 | 1622 | 1622.0 | 0.0 | 0.0 | Dithiothreitol, A New Protective Reagent For Sh Groups. | W W Cleland | Biochemistry | 1964 | 14192894 | Yes |
| 2095 | 4864 | 1621.3 | 175.7 | 58.6 | Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. | Christopher K Prier, Danica A Rankic, David W C MacMillan | Chem Rev | 2013 | 23509883 | No |
| 2096 | 6485 | 1621.2 | 238.3 | 59.6 | MultiQC: summarize analysis results for multiple tools and samples in a single report. | Philip Ewels, Mans Magnusson, Sverker Lundin, Max Kaller | Bioinformatics | 2016 | 27312411 | Yes |
| 2097 | 1621 | 1621.0 | 31.6 | 31.6 | How cells read TGF-beta signals. | J Massague | Nat Rev Mol Cell Biol | 2000 | 11252892 | No |
| 2098 | 4862 | 1620.7 | 153.5 | 51.2 | The Patient Health Questionnaire-2: validity of a two-item depression screener. | Kurt Kroenke, Robert L Spitzer, Janet B W Williams | Med Care | 2003 | 14583691 | Yes |
| 2099 | 1620 | 1620.0 | 53.9 | 53.9 | The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. | G R Buettner | Arch Biochem Biophys | 1993 | 8434935 | No |
| 2100 | 3240 | 1620.0 | 85.9 | 43.0 | Receptors for purines and pyrimidines. | V Ralevic, G Burnstock | Pharmacol Rev | 1998 | 9755289 | No |
| 2101 | 1620 | 1620.0 | 35.9 | 35.9 | Drug discovery: a historical perspective. | J Drews | Science | 2000 | 10720314 | No |
| 2102 | 4860 | 1620.0 | 130.1 | 43.4 | Management of hepatocellular carcinoma. | Jordi Bruix, Morris Sherman, | Hepatology | 2005 | 16250051 | No |
| 2103 | 3239 | 1619.5 | 106.7 | 53.4 | Origins and evolution of antibiotic resistance. | Julian Davies, Dorothy Davies | Microbiol Mol Biol Rev | 2010 | 20805405 | No |
| 2104 | 1619 | 1619.0 | 35.1 | 35.1 | On finding all suboptimal foldings of an RNA molecule. | M Zuker | Science | 1989 | 2468181 | No |
| 2105 | 6474 | 1618.5 | 174.0 | 43.5 | Microbial ecology: human gut microbes associated with obesity. | Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon | Nature | 2006 | 17183309 | Yes |
| 2106 | 3235 | 1617.5 | 88.1 | 44.0 | Diabetes and cardiovascular disease. The Framingham study. | W B Kannel, D L McGee | JAMA | 1979 | 430798 | Yes |
| 2107 | 16175 | 1617.5 | 414.9 | 41.5 | Multilineage potential of adult human mesenchymal stem cells. | M F Pittenger, A M MacKay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak | Science | 1999 | 10102814 | Yes |
| 2108 | 1617 | 1617.0 | 29.6 | 29.6 | Altering the genome by homologous recombination. | M R Capecchi | Science | 1989 | 2660260 | No |
| 2109 | 1617 | 1617.0 | 35.5 | 35.5 | The caveolae membrane system. | R G Anderson | Annu Rev Biochem | 1998 | 9759488 | No |
| 2110 | 1616 | 1616.0 | 51.2 | 51.2 | Evidence for a central component of post-injury pain hypersensitivity. | C J Woolf | Nature | 1983 | 6656869 | Yes |
| 2111 | 1616 | 1616.0 | 48.0 | 48.0 | Electrocatalyst approaches and challenges for automotive fuel cells. | Mark K Debe | Nature | 2012 | 22678278 | Yes |
| 2112 | 1613 | 1613.0 | 43.7 | 43.7 | Breakthrough of the year 2013. Cancer immunotherapy. | Jennifer Couzin-Frankel | Science | 2013 | 24357284 | No |
| 2113 | 3225 | 1612.5 | 81.5 | 40.8 | Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. | F Q Schafer, G R Buettner | Free Radic Biol Med | 2001 | 11368918 | No |
| 2114 | 1612 | 1612.0 | 85.4 | 85.4 | The determinants of parenting: a process model. | J Belsky | Child Dev | 1984 | 6705636 | Yes |
| 2115 | 1612 | 1612.0 | 46.2 | 46.2 | Hemispheric asymmetry reduction in older adults: the HAROLD model. | Roberto Cabeza | Psychol Aging | 2002 | 11931290 | No |
| 2116 | 4833 | 1611.0 | 93.5 | 31.2 | Notch signaling: cell fate control and signal integration in development. | S Artavanis-Tsakonas, M D Rand, R J Lake | Science | 1999 | 10221902 | No |
| 2117 | 3222 | 1611.0 | 122.1 | 61.0 | Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. | Johan W S Vlaeyen, Steven J Linton | Pain | 2000 | 10781906 | No |
| 2118 | 1611 | 1611.0 | 48.0 | 48.0 | Glycobiology: Toward Understanding the Function of Sugars. | Raymond A Dwek | Chem Rev | 1996 | 11848770 | Yes |
| 2119 | 1611 | 1611.0 | 43.5 | 43.5 | Bacteroides: the good, the bad, and the nitty-gritty. | Hannah M Wexler | Clin Microbiol Rev | 2007 | 17934076 | No |
| 2120 | 3220 | 1610.0 | 92.2 | 46.1 | Polyamines. | C W Tabor, H Tabor | Annu Rev Biochem | 1984 | 6206782 | No |
| 2121 | 3220 | 1610.0 | 97.3 | 48.6 | Oxidative stress, glutamate, and neurodegenerative disorders. | J T Coyle, P Puttfarcken | Science | 1993 | 7901908 | No |
| 2122 | 8050 | 1610.0 | 163.8 | 32.8 | Prospective identification of tumorigenic breast cancer cells. | Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke | Proc Natl Acad Sci U S A | 2003 | 12629218 | Yes |
| 2123 | 3220 | 1610.0 | 115.3 | 57.6 | Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. | Christoph Hafemeister, Rahul Satija | Genome Biol | 2019 | 31870423 | Yes |
| 2124 | 1609 | 1609.0 | 48.5 | 48.5 | Levels of racism: a theoretic framework and a gardener's tale. | C P Jones | Am J Public Health | 2000 | 10936998 | Yes |
| 2125 | 1609 | 1609.0 | 50.6 | 50.6 | The amazing osteocyte. | Lynda F Bonewald | J Bone Miner Res | 2011 | 21254230 | No |
| 2126 | 3217 | 1608.5 | 68.0 | 34.0 | Development by self-digestion: molecular mechanisms and biological functions of autophagy. | Beth Levine, Daniel J Klionsky | Dev Cell | 2004 | 15068787 | No |
| 2127 | 6432 | 1608.0 | 191.3 | 47.8 | Reversible middle cerebral artery occlusion without craniectomy in rats. | E Z Longa, P R Weinstein, S Carlson, R Cummins | Stroke | 1989 | 2643202 | Yes |
| 2128 | 1608 | 1608.0 | 81.9 | 81.9 | Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. | Douglas A Drossman | Gastroenterology | 2016 | 27144617 | Yes |
| 2129 | 3214 | 1607.0 | 119.9 | 60.0 | Avoiding false positives with PCR. | S Kwok, R Higuchi | Nature | 1989 | 2716852 | Yes |
| 2130 | 4819 | 1606.3 | 130.2 | 43.4 | I-TASSER: a unified platform for automated protein structure and function prediction. | Ambrish Roy, Alper Kucukural, Yang Zhang | Nat Protoc | 2010 | 20360767 | Yes |
| 2131 | 3211 | 1605.5 | 64.7 | 32.4 | Automated MAD and MIR structure solution. | T C Terwilliger, J Berendzen | Acta Crystallogr D Biol Crystallogr | 1999 | 10089316 | Yes |
| 2132 | 20866 | 1605.1 | 568.0 | 43.7 | Clustal W and Clustal X version 2.0. | M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins | Bioinformatics | 2007 | 17846036 | Yes |
| 2133 | 4815 | 1605.0 | 97.3 | 32.4 | Efficient selection for high-expression transfectants with a novel eukaryotic vector. | H Niwa, K Yamamura, J Miyazaki | Gene | 1991 | 1660837 | Yes |
| 2134 | 1605 | 1605.0 | 0.0 | 0.0 | The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. | A G Pearse | J Histochem Cytochem | 1969 | 4143745 | No |
| 2135 | 1605 | 1605.0 | 59.7 | 59.7 | The prevalence of 'alexithymic' characteristics in psychosomatic patients. | P E Sifneos | Psychother Psychosom | 1973 | 4770536 | Yes |
| 2136 | 1605 | 1605.0 | 37.2 | 37.2 | Cellular oncogenes and retroviruses. | J M Bishop | Annu Rev Biochem | 1983 | 6351725 | No |
| 2137 | 1605 | 1605.0 | 0.0 | 0.0 | Nutrition needs of mammalian cells in tissue culture. | H Eagle | Science | 1955 | 13255879 | Yes |
| 2138 | 1605 | 1605.0 | 35.6 | 35.6 | Far-field optical nanoscopy. | Stefan W Hell | Science | 2007 | 17525330 | No |
| 2139 | 1604 | 1604.0 | 55.9 | 55.9 | Density matrix formulation for quantum renormalization groups. | S R White | Phys Rev Lett | 1992 | 10046608 | Yes |
| 2140 | 3208 | 1604.0 | 109.1 | 54.5 | A cognitive model of posttraumatic stress disorder. | A Ehlers, D M Clark | Behav Res Ther | 2000 | 10761279 | No |
| 2141 | 1604 | 1604.0 | 39.6 | 39.6 | Pathogenesis of group A streptococcal infections. | M W Cunningham | Clin Microbiol Rev | 2000 | 10885988 | No |
| 2142 | 3206 | 1603.0 | 136.6 | 68.3 | AMPK: guardian of metabolism and mitochondrial homeostasis. | Sebastien Herzig, Reuben J Shaw | Nat Rev Mol Cell Biol | 2018 | 28974774 | No |
| 2143 | 3205 | 1602.5 | 69.3 | 34.6 | Inhibitors of mammalian G1 cyclin-dependent kinases. | C J Sherr, J M Roberts | Genes Dev | 1995 | 7758941 | No |
| 2144 | 1602 | 1602.0 | 65.1 | 65.1 | The Laboratory Rat: Relating Its Age With Human's. | Pallav Sengupta | Int J Prev Med | 2013 | 23930179 | Yes |
| 2145 | 1602 | 1602.0 | 373.7 | 373.7 | A comprehensive electron wavefunction analysis toolbox for chemists, Multiwfn. | Tian Lu | J Chem Phys | 2024 | 39189657 | Yes |
| 2146 | 3202 | 1601.0 | 80.0 | 40.0 | A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1985 | 3156376 | Yes |
| 2147 | 1601 | 1601.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. | O Ouchterlony | Acta Pathol Microbiol Scand | 1953 | 13079779 | Yes |
| 2148 | 4802 | 1600.7 | 119.0 | 39.7 | Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. | Robert D Schreiber, Lloyd J Old, Mark J Smyth | Science | 2011 | 21436444 | No |
| 2149 | 1600 | 1600.0 | 32.2 | 32.2 | An analysis of vertebrate mRNA sequences: intimations of translational control. | M Kozak | J Cell Biol | 1991 | 1955461 | No |
| 2150 | 3199 | 1599.5 | 132.4 | 66.2 | Using Effect Size-or Why the P Value Is Not Enough. | Gail M Sullivan, Richard Feinn | J Grad Med Educ | 2012 | 23997866 | Yes |
| 2151 | 4795 | 1598.3 | 127.7 | 42.6 | Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. | Y Zhang, M Brady, S Smith | IEEE Trans Med Imaging | 2001 | 11293691 | Yes |
| 2152 | 1598 | 1598.0 | 40.9 | 40.9 | Tumor necrosis factor (TNF). | L J Old | Science | 1985 | 2413547 | Yes |
| 2153 | 1598 | 1598.0 | 72.8 | 72.8 | The measurement of psychological androgyny. | S L Bem | J Consult Clin Psychol | 1974 | 4823550 | Yes |
| 2154 | 3196 | 1598.0 | 64.1 | 32.0 | Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. | O Tetsu, F McCormick | Nature | 1999 | 10201372 | Yes |
| 2155 | 1598 | 1598.0 | 68.5 | 68.5 | Salience processing and insular cortical function and dysfunction. | Lucina Q Uddin | Nat Rev Neurosci | 2015 | 25406711 | No |
| 2156 | 3195 | 1597.5 | 66.6 | 33.3 | Short-term synaptic plasticity. | Robert S Zucker, Wade G Regehr | Annu Rev Physiol | 2002 | 11826273 | No |
| 2157 | 1597 | 1597.0 | 32.4 | 32.4 | The ubiquitin-proteasome proteolytic pathway. | A Ciechanover | Cell | 1994 | 7923371 | No |
| 2158 | 4787 | 1595.7 | 173.6 | 57.9 | Phylogenetic identification and in situ detection of individual microbial cells without cultivation. | R I Amann, W Ludwig, K H Schleifer | Microbiol Rev | 1995 | 7535888 | No |
| 2159 | 9574 | 1595.7 | 371.7 | 61.9 | Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. | Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C Lowery | Implement Sci | 2009 | 19664226 | Yes |
| 2160 | 3188 | 1594.0 | 110.9 | 55.5 | Social conditions as fundamental causes of disease. | B G Link, J Phelan | J Health Soc Behav | 1995 | 7560851 | No |
| 2161 | 3188 | 1594.0 | 109.6 | 54.8 | Nitric oxide synthases: regulation and function. | Ulrich Forstermann, William C Sessa | Eur Heart J | 2012 | 21890489 | No |
| 2162 | 1593 | 1593.0 | 83.3 | 83.3 | Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. | P De Leva | J Biomech | 1996 | 8872282 | Yes |
| 2163 | 1592 | 1592.0 | 46.7 | 46.7 | Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. | W H Oldendorf | Am J Physiol | 1971 | 5124307 | Yes |
| 2164 | 1592 | 1592.0 | 39.5 | 39.5 | HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. | J M Coffin | Science | 1995 | 7824947 | Yes |
| 2165 | 1592 | 1592.0 | 45.2 | 45.2 | The complete general secretory pathway in gram-negative bacteria. | A P Pugsley | Microbiol Rev | 1993 | 8096622 | No |
| 2166 | 1592 | 1592.0 | 50.9 | 50.9 | Domino Reactions in Organic Synthesis. | Lutz F Tietze | Chem Rev | 1996 | 11848746 | Yes |
| 2167 | 1592 | 1592.0 | 55.2 | 55.2 | AmpC beta-lactamases. | George A Jacoby | Clin Microbiol Rev | 2009 | 19136439 | No |
| 2168 | 1591 | 1591.0 | 0.0 | 0.0 | A New Weighting System For Mean Surface Temperature Of The Human Body. | N L Ramanathan | J Appl Physiol | 1964 | 14173555 | Yes |
| 2169 | 3182 | 1591.0 | 103.7 | 51.9 | CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data. | Jing Huang, Alexander D MacKerell | J Comput Chem | 2013 | 23832629 | Yes |
| 2170 | 4772 | 1590.7 | 149.4 | 49.8 | Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. | S Van Der Linden, H A Valkenburg, A Cats | Arthritis Rheum | 1984 | 6231933 | Yes |
| 2171 | 1590 | 1590.0 | 37.2 | 37.2 | VLA proteins in the integrin family: structures, functions, and their role on leukocytes. | M E Hemler | Annu Rev Immunol | 1990 | 2188667 | No |
| 2172 | 1590 | 1590.0 | 0.0 | 0.0 | The intraclass correlation coefficient as a measure of reliability. | J J Bartko | Psychol Rep | 1966 | 5942109 | Yes |
| 2173 | 4770 | 1590.0 | 164.7 | 54.9 | Evaluating the public health impact of health promotion interventions: the RE-AIM framework. | R E Glasgow, T M Vogt, S M Boles | Am J Public Health | 1999 | 10474547 | No |
| 2174 | 4767 | 1589.0 | 258.8 | 86.3 | Improved metagenomic analysis with Kraken 2. | Derrick E Wood, Jennifer Lu, Ben Langmead | Genome Biol | 2019 | 31779668 | Yes |
| 2175 | 1588 | 1588.0 | 62.7 | 62.7 | Bias in analytic research. | D L Sackett | J Chronic Dis | 1979 | 447779 | Yes |
| 2176 | 1588 | 1588.0 | 49.7 | 49.7 | The pollution of the marine environment by plastic debris: a review. | Jose G B Derraik | Mar Pollut Bull | 2002 | 12405208 | No |
| 2177 | 1588 | 1588.0 | 49.9 | 49.9 | Treatment of infections associated with surgical implants. | Rabih O Darouiche | N Engl J Med | 2004 | 15070792 | No |
| 2178 | 1587 | 1587.0 | 66.2 | 66.2 | Reliability and factor analysis of the Epworth Sleepiness Scale. | M W Johns | Sleep | 1992 | 1519015 | Yes |
| 2179 | 1587 | 1587.0 | 57.3 | 57.3 | Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. | J J Gross | J Pers Soc Psychol | 1998 | 9457784 | Yes |
| 2180 | 1586 | 1586.0 | 51.1 | 51.1 | Formation of glasses from liquids and biopolymers. | C A Angell | Science | 1995 | 17770101 | Yes |
| 2181 | 3171 | 1585.5 | 102.2 | 51.1 | The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. | R Doll, R Peto | J Natl Cancer Inst | 1981 | 7017215 | No |
| 2182 | 3170 | 1585.0 | 100.6 | 50.3 | Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. | D S Bredt, S H Snyder | Proc Natl Acad Sci U S A | 1990 | 1689048 | Yes |
| 2183 | 1584 | 1584.0 | 37.4 | 37.4 | The proto-oncogene Bcl-2 and its role in regulating apoptosis. | G Kroemer | Nat Med | 1997 | 9176486 | No |
| 2184 | 3166 | 1583.0 | 63.4 | 31.7 | Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. | C B Lozzio, B B Lozzio | Blood | 1975 | 163658 | Yes |
| 2185 | 1583 | 1583.0 | 37.1 | 37.1 | Recent advances in neuroblastoma. | John M Maris | N Engl J Med | 2010 | 20558371 | No |
| 2186 | 1582 | 1582.0 | 40.6 | 40.6 | Type I diabetes mellitus. A chronic autoimmune disease. | G S Eisenbarth | N Engl J Med | 1986 | 3517648 | No |
| 2187 | 1582 | 1582.0 | 43.6 | 43.6 | Molecular bases of the acute coronary syndromes. | P Libby | Circulation | 1995 | 7758192 | No |
| 2188 | 1582 | 1582.0 | 29.9 | 29.9 | Germinal centers. | I C MacLennan | Annu Rev Immunol | 1994 | 8011279 | No |
| 2189 | 1582 | 1582.0 | 47.9 | 47.9 | Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. | Louis B Rice | J Infect Dis | 2008 | 18419525 | No |
| 2190 | 6327 | 1581.8 | 126.9 | 31.7 | A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. | B M Bolstad, R A Irizarry, M Astrand, T P Speed | Bioinformatics | 2003 | 12538238 | Yes |
| 2191 | 1581 | 1581.0 | 36.3 | 36.3 | The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. | S E Kahn | Diabetologia | 2003 | 12637977 | No |
| 2192 | 3162 | 1581.0 | 108.9 | 54.5 | Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. | John F Cryan, Timothy G Dinan | Nat Rev Neurosci | 2012 | 22968153 | No |
| 2193 | 4742 | 1580.7 | 190.7 | 63.6 | Job burnout. | C Maslach, W B Schaufeli, M P Leiter | Annu Rev Psychol | 2001 | 11148311 | Yes |
| 2194 | 1580 | 1580.0 | 40.4 | 40.4 | Neuronal synchrony: a versatile code for the definition of relations? | W Singer | Neuron | 1999 | 10677026 | No |
| 2195 | 1580 | 1580.0 | 0.0 | 0.0 | A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. | B C Hummel | Can J Biochem Physiol | 1959 | 14405350 | Yes |
| 2196 | 4740 | 1580.0 | 153.1 | 51.0 | Mendelian randomization analysis with multiple genetic variants using summarized data. | Stephen Burgess, Adam Butterworth, Simon G Thompson | Genet Epidemiol | 2013 | 24114802 | Yes |
| 2197 | 1579 | 1579.0 | 54.4 | 54.4 | Biology of interleukin 1. | C A Dinarello | FASEB J | 1988 | 3277884 | No |
| 2198 | 1578 | 1578.0 | 45.6 | 45.6 | Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. | S Hakomori | Annu Rev Biochem | 1981 | 7023369 | No |
| 2199 | 1578 | 1578.0 | 35.8 | 35.8 | Mitochondria: dynamic organelles in disease, aging, and development. | David C Chan | Cell | 2006 | 16814712 | No |
| 2200 | 3155 | 1577.5 | 84.4 | 42.2 | Empirical threshold values for quantitative trait mapping. | G A Churchill, R W Doerge | Genetics | 1994 | 7851788 | Yes |
| 2201 | 1577 | 1577.0 | 64.1 | 64.1 | Regulation of noradrenaline release by presynaptic receptor systems. | K Starke | Rev Physiol Biochem Pharmacol | 1977 | 14389 | No |
| 2202 | 1577 | 1577.0 | 37.3 | 37.3 | Cell signaling. H2O2, a necessary evil for cell signaling. | Sue Goo Rhee | Science | 2006 | 16809515 | Yes |
| 2203 | 3153 | 1576.5 | 106.6 | 53.3 | From best evidence to best practice: effective implementation of change in patients' care. | Richard Grol, Jeremy Grimshaw | Lancet | 2003 | 14568747 | No |
| 2204 | 3149 | 1574.5 | 0.0 | 0.0 | Junctional complexes in various epithelia. | M G Farquhar, G E Palade | J Cell Biol | 1963 | 13944428 | Yes |
| 2205 | 1574 | 1574.0 | 43.7 | 43.7 | Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. | A Fabiato | Am J Physiol | 1983 | 6346892 | No |
| 2206 | 1573 | 1573.0 | 61.3 | 61.3 | Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. | P Holzer | Neuroscience | 1988 | 3288903 | No |
| 2207 | 1573 | 1573.0 | 59.4 | 59.4 | Cardiac valve surgery--the "French correction". | A Carpentier | J Thorac Cardiovasc Surg | 1983 | 6887954 | Yes |
| 2208 | 3146 | 1573.0 | 85.9 | 43.0 | Verification of protein structures: patterns of nonbonded atomic interactions. | C Colovos, T O Yeates | Protein Sci | 1993 | 8401235 | Yes |
| 2209 | 1573 | 1573.0 | 34.2 | 34.2 | Autophagy: from phenomenology to molecular understanding in less than a decade. | Daniel J Klionsky | Nat Rev Mol Cell Biol | 2007 | 17712358 | No |
| 2210 | 18869 | 1572.4 | 1328.4 | 110.7 | The REDCap consortium: Building an international community of software platform partners. | Paul A Harris, Robert Taylor, Brenda L Minor, Veida Elliott, Michelle Fernandez, Lindsay O'Neal, Laura McLeod, Giovanni Delacqua, Francesco Delacqua, Jacqueline Kirby, Stephany N Duda, | J Biomed Inform | 2019 | 31078660 | Yes |
| 2211 | 1570 | 1570.0 | 36.9 | 36.9 | Huntington's disease. | Francis O Walker | Lancet | 2007 | 17240289 | No |
| 2212 | 4709 | 1569.7 | 174.2 | 58.1 | Factor structure of the Barratt impulsiveness scale. | J H Patton, M S Stanford, E S Barratt | J Clin Psychol | 1995 | 8778124 | Yes |
| 2213 | 1569 | 1569.0 | 0.0 | 0.0 | The Relation Of Recombination To Mutational Advance. | H J Muller | Mutat Res | 1964 | 14195748 | Yes |
| 2214 | 3138 | 1569.0 | 90.7 | 45.4 | Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. | Christine Vogel, Edward M Marcotte | Nat Rev Genet | 2012 | 22411467 | No |
| 2215 | 1568 | 1568.0 | 33.3 | 33.3 | Cancer epigenomics: DNA methylomes and histone-modification maps. | Manel Esteller | Nat Rev Genet | 2007 | 17339880 | No |
| 2216 | 10964 | 1566.3 | 242.1 | 34.6 | Embryonic stem cell lines derived from human blastocysts. | J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones | Science | 1998 | 9804556 | Yes |
| 2217 | 1566 | 1566.0 | 107.4 | 107.4 | The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. | F Denis | Spine (Phila Pa 1976) | 1983 | 6670016 | Yes |
| 2218 | 1566 | 1566.0 | 40.6 | 40.6 | Proinflammatory cytokines. | C A Dinarello | Chest | 2000 | 10936147 | No |
| 2219 | 1566 | 1566.0 | 30.2 | 30.2 | Aggresomes, inclusion bodies and protein aggregation. | R R Kopito | Trends Cell Biol | 2000 | 11121744 | No |
| 2220 | 3130 | 1565.0 | 0.0 | 0.0 | Computed circular dichroism spectra for the evaluation of protein conformation. | N Greenfield, G D Fasman | Biochemistry | 1969 | 5346390 | Yes |
| 2221 | 1565 | 1565.0 | 66.2 | 66.2 | Minority stress and mental health in gay men. | I H Meyer | J Health Soc Behav | 1995 | 7738327 | Yes |
| 2222 | 3130 | 1565.0 | 70.6 | 35.3 | Cell migration: a physically integrated molecular process. | D A Lauffenburger, A F Horwitz | Cell | 1996 | 8608589 | No |
| 2223 | 1565 | 1565.0 | 48.1 | 48.1 | The Danish Register of Causes of Death. | Karin Helweg-Larsen | Scand J Public Health | 2011 | 21775346 | Yes |
| 2224 | 3129 | 1564.5 | 108.0 | 54.0 | The framing of decisions and the psychology of choice. | A Tversky, D Kahneman | Science | 1981 | 7455683 | Yes |
| 2225 | 4691 | 1563.7 | 118.8 | 39.6 | Cell death: the significance of apoptosis. | A H Wyllie, J F Kerr, A R Currie | Int Rev Cytol | 1980 | 7014501 | No |
| 2226 | 3127 | 1563.5 | 164.3 | 82.2 | Depression. | Gin S Malhi, J John Mann | Lancet | 2018 | 30396512 | No |
| 2227 | 4690 | 1563.3 | 114.5 | 38.2 | Wnt/beta-catenin signaling: components, mechanisms, and diseases. | Bryan T MacDonald, Keiko Tamai, Xi He | Dev Cell | 2009 | 19619488 | No |
| 2228 | 1563 | 1563.0 | 33.8 | 33.8 | Physiological concentrations of purines and pyrimidines. | T W Traut | Mol Cell Biochem | 1994 | 7877593 | No |
| 2229 | 1563 | 1563.0 | 43.9 | 43.9 | Diagnosis of osteoporosis and assessment of fracture risk. | John A Kanis | Lancet | 2002 | 12057569 | No |
| 2230 | 1561 | 1561.0 | 46.6 | 46.6 | Strong localization of photons in certain disordered dielectric superlattices. | S John | Phys Rev Lett | 1987 | 10034761 | Yes |
| 2231 | 4681 | 1560.3 | 134.6 | 44.9 | AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. | G Paxinos, C R Watson, P C Emson | J Neurosci Methods | 1980 | 6110810 | Yes |
| 2232 | 1560 | 1560.0 | 70.7 | 70.7 | Stimulated acoustic emissions from within the human auditory system. | D T Kemp | J Acoust Soc Am | 1978 | 744838 | Yes |
| 2233 | 1560 | 1560.0 | 44.4 | 44.4 | Genetic consequences of climatic oscillations in the Quaternary. | G M Hewitt | Philos Trans R Soc Lond B Biol Sci | 2004 | 15101575 | No |
| 2234 | 3120 | 1560.0 | 64.6 | 32.3 | Toll-like receptor control of the adaptive immune responses. | Akiko Iwasaki, Ruslan Medzhitov | Nat Immunol | 2004 | 15454922 | No |
| 2235 | 1560 | 1560.0 | 45.1 | 45.1 | Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. | Michael F Holick | Am J Clin Nutr | 2004 | 15585788 | No |
| 2236 | 1560 | 1560.0 | 0.0 | 0.0 | The estimation of phosphorus. | R J Allen | Biochem J | 1940 | 16747230 | Yes |
| 2237 | 3119 | 1559.5 | 88.7 | 44.4 | Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. | Robert E W Hancock, Hans-Georg Sahl | Nat Biotechnol | 2006 | 17160061 | No |
| 2238 | 1559 | 1559.0 | 47.7 | 47.7 | Equipoise and the ethics of clinical research. | B Freedman | N Engl J Med | 1987 | 3600702 | Yes |
| 2239 | 3117 | 1558.5 | 0.0 | 0.0 | Mutations of Bacteria from Virus Sensitivity to Virus Resistance. | S E Luria, M Delbruck | Genetics | 1943 | 17247100 | Yes |
| 2240 | 1558 | 1558.0 | 50.9 | 50.9 | Depression in late life: review and commentary. | Dan G Blazer | J Gerontol A Biol Sci Med Sci | 2003 | 12634292 | No |
| 2241 | 7786 | 1557.2 | 192.7 | 38.5 | Jalview Version 2--a multiple sequence alignment editor and analysis workbench. | Andrew M Waterhouse, James B Procter, David M A Martin, Michele Clamp, Geoffrey J Barton | Bioinformatics | 2009 | 19151095 | Yes |
| 2242 | 1557 | 1557.0 | 44.0 | 44.0 | Biological applications of ionophores. | B C Pressman | Annu Rev Biochem | 1976 | 786156 | No |
| 2243 | 1557 | 1557.0 | 44.8 | 44.8 | Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. | A E Pegg | Cancer Res | 1988 | 3123052 | No |
| 2244 | 1557 | 1557.0 | 36.7 | 36.7 | The molecular logic of endocannabinoid signalling. | Daniele Piomelli | Nat Rev Neurosci | 2003 | 14595399 | No |
| 2245 | 1557 | 1557.0 | 42.9 | 42.9 | Regulation of glutathione synthesis. | Shelly C Lu | Mol Aspects Med | 2009 | 18601945 | No |
| 2246 | 3114 | 1557.0 | 102.9 | 51.5 | Functional interactions between the gut microbiota and host metabolism. | Valentina Tremaroli, Fredrik Backhed | Nature | 2012 | 22972297 | No |
| 2247 | 1557 | 1557.0 | 68.2 | 68.2 | Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. | Dariush Mozaffarian | Circulation | 2016 | 26746178 | No |
| 2248 | 1556 | 1556.0 | 43.4 | 43.4 | An economic method for the fluorescent labeling of PCR fragments. | M Schuelke | Nat Biotechnol | 2000 | 10657137 | Yes |
| 2249 | 1556 | 1556.0 | 45.4 | 45.4 | A comprehensive definition for metabolic syndrome. | Paul L Huang | Dis Model Mech | 2009 | 19407331 | No |
| 2250 | 1556 | 1556.0 | 65.3 | 65.3 | How does sexual minority stigma "get under the skin"? A psychological mediation framework. | Mark L Hatzenbuehler | Psychol Bull | 2009 | 19702379 | No |
| 2251 | 4667 | 1555.7 | 203.0 | 67.7 | Hepatocellular carcinoma. | Alejandro Forner, Maria Reig, Jordi Bruix | Lancet | 2018 | 29307467 | No |
| 2252 | 3106 | 1553.0 | 76.4 | 38.2 | Emerging roles of caspase-3 in apoptosis. | A G Porter, R U Janicke | Cell Death Differ | 1999 | 10200555 | No |
| 2253 | 4655 | 1551.7 | 104.4 | 34.8 | Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. | M A Frohman, M K Dush, G R Martin | Proc Natl Acad Sci U S A | 1988 | 2461560 | Yes |
| 2254 | 3102 | 1551.0 | 95.6 | 47.8 | CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. | Mattias Jakobsson, Noah A Rosenberg | Bioinformatics | 2007 | 17485429 | Yes |
| 2255 | 3101 | 1550.5 | 113.3 | 56.6 | Kraken: ultrafast metagenomic sequence classification using exact alignments. | Derrick E Wood, Steven L Salzberg | Genome Biol | 2014 | 24580807 | Yes |
| 2256 | 1550 | 1550.0 | 0.0 | 0.0 | A soluble protein characteristic of the nervous system. | B W Moore | Biochem Biophys Res Commun | 1965 | 4953930 | Yes |
| 2257 | 4650 | 1550.0 | 102.2 | 34.1 | TOR signaling in growth and metabolism. | Stephan Wullschleger, Robbie Loewith, Michael N Hall | Cell | 2006 | 16469695 | No |
| 2258 | 1550 | 1550.0 | 48.7 | 48.7 | Species concepts and species delimitation. | Kevin De Queiroz | Syst Biol | 2007 | 18027281 | Yes |
| 2259 | 1550 | 1550.0 | 43.1 | 43.1 | Graphene transistors. | Frank Schwierz | Nat Nanotechnol | 2010 | 20512128 | Yes |
| 2260 | 3099 | 1549.5 | 63.2 | 31.6 | Intrinsically unstructured proteins and their functions. | H Jane Dyson, Peter E Wright | Nat Rev Mol Cell Biol | 2005 | 15738986 | No |
| 2261 | 3099 | 1549.5 | 81.7 | 40.9 | Tumor metastasis: molecular insights and evolving paradigms. | Scott Valastyan, Robert A Weinberg | Cell | 2011 | 22000009 | No |
| 2262 | 1549 | 1549.0 | 59.2 | 59.2 | Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. | P Holzer | Pharmacol Rev | 1991 | 1852779 | No |
| 2263 | 1549 | 1549.0 | 44.6 | 44.6 | Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. | Y Ben-Ari | Neuroscience | 1985 | 2859548 | No |
| 2264 | 3098 | 1549.0 | 74.1 | 37.0 | How matrix metalloproteinases regulate cell behavior. | M D Sternlicht, Z Werb | Annu Rev Cell Dev Biol | 2001 | 11687497 | No |
| 2265 | 1549 | 1549.0 | 51.6 | 51.6 | Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. | M Robin DiMatteo | Med Care | 2004 | 15076819 | Yes |
| 2266 | 1549 | 1549.0 | 41.1 | 41.1 | The amygdala modulates the consolidation of memories of emotionally arousing experiences. | James L McGaugh | Annu Rev Neurosci | 2004 | 15217324 | No |
| 2267 | 1549 | 1549.0 | 52.6 | 52.6 | Photoplethysmography and its application in clinical physiological measurement. | John Allen | Physiol Meas | 2007 | 17322588 | No |
| 2268 | 3095 | 1547.5 | 78.0 | 39.0 | Myocardial reperfusion injury. | Derek M Yellon, Derek J Hausenloy | N Engl J Med | 2007 | 17855673 | No |
| 2269 | 1547 | 1547.0 | 53.5 | 53.5 | Gene flow and the geographic structure of natural populations. | M Slatkin | Science | 1987 | 3576198 | Yes |
| 2270 | 1547 | 1547.0 | 61.3 | 61.3 | Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? | Fay B Horak | Age Ageing | 2006 | 16926210 | No |
| 2271 | 1547 | 1547.0 | 38.2 | 38.2 | Origin, biogenesis, and activity of plant microRNAs. | Olivier Voinnet | Cell | 2009 | 19239888 | No |
| 2272 | 4639 | 1546.3 | 98.5 | 32.8 | The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. | S K Hanks, A M Quinn, T Hunter | Science | 1988 | 3291115 | No |
| 2273 | 4635 | 1545.0 | 110.1 | 36.7 | Long non-coding RNAs: insights into functions. | Tim R Mercer, Marcel E Dinger, John S Mattick | Nat Rev Genet | 2009 | 19188922 | No |
| 2274 | 1545 | 1545.0 | 65.4 | 65.4 | Environmentally induced oxidative stress in aquatic animals. | Volodymyr I Lushchak | Aquat Toxicol | 2011 | 21074869 | No |
| 2275 | 3088 | 1544.0 | 102.9 | 51.5 | New Giemsa method for the differential staining of sister chromatids. | P Perry, S Wolff | Nature | 1974 | 4138930 | Yes |
| 2276 | 3088 | 1544.0 | 109.0 | 54.5 | Liposomal drug delivery systems: from concept to clinical applications. | Theresa M Allen, Pieter R Cullis | Adv Drug Deliv Rev | 2013 | 23036225 | No |
| 2277 | 4631 | 1543.7 | 130.0 | 43.3 | A highly sensitive adenylate cyclase assay. | Y Salomon, C Londos, M Rodbell | Anal Biochem | 1974 | 4827395 | Yes |
| 2278 | 1543 | 1543.0 | 0.0 | 0.0 | The glomerular permeability determined by dextran clearance using Sephadex gel filtration. | C E Mogensen | Scand J Clin Lab Invest | 1968 | 5637478 | Yes |
| 2279 | 4629 | 1543.0 | 175.9 | 58.6 | Principles of nanoparticle design for overcoming biological barriers to drug delivery. | Elvin Blanco, Haifa Shen, Mauro Ferrari | Nat Biotechnol | 2015 | 26348965 | Yes |
| 2280 | 1542 | 1542.0 | 44.9 | 44.9 | Atherogenesis: a postprandial phenomenon. | D B Zilversmit | Circulation | 1979 | 222498 | Yes |
| 2281 | 1542 | 1542.0 | 46.6 | 46.6 | Biological basis of the behavior of sick animals. | B L Hart | Neurosci Biobehav Rev | 1988 | 3050629 | No |
| 2282 | 1542 | 1542.0 | 33.6 | 33.6 | The enzymes, regulation, and genetics of bile acid synthesis. | David W Russell | Annu Rev Biochem | 2003 | 12543708 | No |
| 2283 | 1542 | 1542.0 | 61.9 | 61.9 | The variable nature of cognitive control: a dual mechanisms framework. | Todd S Braver | Trends Cogn Sci | 2012 | 22245618 | Yes |
| 2284 | 1541 | 1541.0 | 29.2 | 29.2 | CD4+ CD25+ suppressor T cells: more questions than answers. | Ethan M Shevach | Nat Rev Immunol | 2002 | 12093005 | No |
| 2285 | 3081 | 1540.5 | 98.4 | 49.2 | Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. | P J Basser, C Pierpaoli | J Magn Reson B | 1996 | 8661285 | Yes |
| 2286 | 1539 | 1539.0 | 30.7 | 30.7 | E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. | J R Nevins | Science | 1992 | 1411535 | Yes |
| 2287 | 3077 | 1538.5 | 0.0 | 0.0 | A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. | G Schmidt, S J Thannhauser | J Biol Chem | 1945 | 21005717 | Yes |
| 2288 | 1537 | 1537.0 | 39.6 | 39.6 | R factor transfer in Rhizobium leguminosarum. | J E Beringer | J Gen Microbiol | 1974 | 4612098 | Yes |
| 2289 | 1537 | 1537.0 | 47.7 | 47.7 | Leishmaniasis: current situation and new perspectives. | P Desjeux | Comp Immunol Microbiol Infect Dis | 2004 | 15225981 | No |
| 2290 | 3074 | 1537.0 | 99.5 | 49.8 | DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. | Yan Chao-Gan, Zang Yu-Feng | Front Syst Neurosci | 2010 | 20577591 | Yes |
| 2291 | 1536 | 1536.0 | 44.0 | 44.0 | The world health report 2002 - reducing risks, promoting healthy life. | J J Guilbert | Educ Health (Abingdon) | 2003 | 14741909 | Yes |
| 2292 | 1536 | 1536.0 | 30.7 | 30.7 | The significance of responses of the genome to challenge. | B McClintock | Science | 1984 | 15739260 | No |
| 2293 | 1535 | 1535.0 | 27.6 | 27.6 | Histone acetylation and transcriptional regulatory mechanisms. | K Struhl | Genes Dev | 1998 | 9499396 | No |
| 2294 | 3069 | 1534.5 | 65.9 | 33.0 | The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. | M S Brown, J L Goldstein | Cell | 1997 | 9150132 | No |
| 2295 | 1534 | 1534.0 | 45.6 | 45.6 | Statistical analysis of enzyme kinetic data. | W W Cleland | Methods Enzymol | 1979 | 502857 | Yes |
| 2296 | 1534 | 1534.0 | 34.7 | 34.7 | Molecular themes in oncogenesis. | J M Bishop | Cell | 1991 | 1988146 | No |
| 2297 | 1534 | 1534.0 | 42.7 | 42.7 | Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. | L A Liotta | Cancer Res | 1986 | 2998604 | No |
| 2298 | 1534 | 1534.0 | 47.7 | 47.7 | Recent advances in the biochemistry of polyamines in eukaryotes. | A E Pegg | Biochem J | 1986 | 3087344 | No |
| 2299 | 1534 | 1534.0 | 0.0 | 0.0 | Codon--anticodon pairing: the wobble hypothesis. | F H Crick | J Mol Biol | 1966 | 5969078 | Yes |
| 2300 | 4599 | 1533.0 | 99.9 | 33.3 | Telomeres shorten during ageing of human fibroblasts. | C B Harley, A B Futcher, C W Greider | Nature | 1990 | 2342578 | Yes |
| 2301 | 1533 | 1533.0 | 52.6 | 52.6 | Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. | H J Gundersen | J Microsc | 1986 | 3761363 | Yes |
| 2302 | 6132 | 1533.0 | 141.7 | 35.4 | Probability-based protein identification by searching sequence databases using mass spectrometry data. | D N Perkins, D J Pappin, D M Creasy, J S Cottrell | Electrophoresis | 1999 | 10612281 | Yes |
| 2303 | 1532 | 1532.0 | 62.9 | 62.9 | Diagnostic and Statistical Manual of Mental Disorders (DSM). | Dolores Elaine Battle | Codas | 2013 | 24413388 | Yes |
| 2304 | 1532 | 1532.0 | 56.5 | 56.5 | The non-canonical NF-κB pathway in immunity and inflammation. | Shao-Cong Sun | Nat Rev Immunol | 2017 | 28580957 | No |
| 2305 | 4594 | 1531.3 | 131.2 | 43.7 | Hydroperoxide metabolism in mammalian organs. | B Chance, H Sies, A Boveris | Physiol Rev | 1979 | 37532 | Yes |
| 2306 | 1531 | 1531.0 | 44.7 | 44.7 | The debate over dopamine's role in reward: the case for incentive salience. | Kent C Berridge | Psychopharmacology (Berl) | 2007 | 17072591 | No |
| 2307 | 3061 | 1530.5 | 98.2 | 49.1 | Functional architecture of basal ganglia circuits: neural substrates of parallel processing. | G E Alexander, M D Crutcher | Trends Neurosci | 1990 | 1695401 | No |
| 2308 | 1529 | 1529.0 | 66.7 | 66.7 | The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. | E J Khantzian | Am J Psychiatry | 1985 | 3904487 | No |
| 2309 | 3058 | 1529.0 | 82.9 | 41.5 | An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. | Gary Aston-Jones, Jonathan D Cohen | Annu Rev Neurosci | 2005 | 16022602 | No |
| 2310 | 4585 | 1528.3 | 0.0 | 0.0 | Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. | C A Winter, E A Risley, G W Nuss | Proc Soc Exp Biol Med | 1962 | 14001233 | Yes |
| 2311 | 1528 | 1528.0 | 0.0 | 0.0 | Some observations upon a new inhibitor of monoamine oxidase in brain tissue. | J P Johnston | Biochem Pharmacol | 1968 | 5659776 | Yes |
| 2312 | 1528 | 1528.0 | 27.2 | 27.2 | The economics of ribosome biosynthesis in yeast. | J R Warner | Trends Biochem Sci | 1999 | 10542411 | No |
| 2313 | 1528 | 1528.0 | 55.1 | 55.1 | Health consequences of obesity in youth: childhood predictors of adult disease. | W H Dietz | Pediatrics | 1998 | 12224658 | No |
| 2314 | 1528 | 1528.0 | 0.0 | 0.0 | Antigen-Antibody Crossed Electrophoresis. | C B Laurell | Anal Biochem | 1965 | 14302464 | Yes |
| 2315 | 1528 | 1528.0 | 64.1 | 64.1 | The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. | Natalie A De Morton | Aust J Physiother | 2009 | 19463084 | Yes |
| 2316 | 1527 | 1527.0 | 0.0 | 0.0 | An enzymic method for the trace iodination of immunoglobulins and other proteins. | J J Marchalonis | Biochem J | 1969 | 4185494 | Yes |
| 2317 | 1527 | 1527.0 | 47.4 | 47.4 | The collagen family. | Sylvie Ricard-Blum | Cold Spring Harb Perspect Biol | 2011 | 21421911 | No |
| 2318 | 24426 | 1526.6 | 699.1 | 43.7 | New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). | E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J Verweij | Eur J Cancer | 2009 | 19097774 | No |
| 2319 | 1526 | 1526.0 | 44.7 | 44.7 | Calcium release from the sarcoplasmic reticulum. | M Endo | Physiol Rev | 1977 | 13441 | Yes |
| 2320 | 7630 | 1526.0 | 316.9 | 63.4 | DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. | O Folmer, M Black, W Hoeh, R Lutz, R Vrijenhoek | Mol Mar Biol Biotechnol | 1994 | 7881515 | Yes |
| 2321 | 1525 | 1525.0 | 58.7 | 58.7 | The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. | A Raine | Schizophr Bull | 1991 | 1805349 | Yes |
| 2322 | 1525 | 1525.0 | 0.0 | 0.0 | Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. | J W Olney | Science | 1969 | 5778021 | Yes |
| 2323 | 1525 | 1525.0 | 41.6 | 41.6 | Stress and hippocampal plasticity. | B S McEwen | Annu Rev Neurosci | 1999 | 10202533 | No |
| 2324 | 1525 | 1525.0 | 43.7 | 43.7 | The epidemiology of venous thromboembolism. | Richard H White | Circulation | 2003 | 12814979 | No |
| 2325 | 3050 | 1525.0 | 129.3 | 64.7 | Organic Photoredox Catalysis. | Nathan A Romero, David A Nicewicz | Chem Rev | 2016 | 27285582 | Yes |
| 2326 | 3049 | 1524.5 | 61.9 | 30.9 | Autophagy as a regulated pathway of cellular degradation. | D J Klionsky, S D Emr | Science | 2000 | 11099404 | No |
| 2327 | 3049 | 1524.5 | 69.9 | 35.0 | Cell cycle, CDKs and cancer: a changing paradigm. | Marcos Malumbres, Mariano Barbacid | Nat Rev Cancer | 2009 | 19238148 | No |
| 2328 | 1524 | 1524.0 | 58.8 | 58.8 | Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. | T Florian Jaeger | J Mem Lang | 2008 | 19884961 | Yes |
| 2329 | 3047 | 1523.5 | 77.2 | 38.6 | Peptidoglycan types of bacterial cell walls and their taxonomic implications. | K H Schleifer, O Kandler | Bacteriol Rev | 1972 | 4568761 | No |
| 2330 | 3047 | 1523.5 | 172.3 | 86.2 | Sarcopenia. | Alfonso J Cruz-Jentoft, Avan A Sayer | Lancet | 2019 | 31171417 | No |
| 2331 | 3046 | 1523.0 | 78.6 | 39.3 | Synchronization of Plasmodium falciparum erythrocytic stages in culture. | C Lambros, J P Vanderberg | J Parasitol | 1979 | 383936 | Yes |
| 2332 | 1523 | 1523.0 | 40.3 | 40.3 | Early signals in the mitogenic response. | E Rozengurt | Science | 1986 | 3018928 | No |
| 2333 | 1523 | 1523.0 | 63.1 | 63.1 | Translating social ecological theory into guidelines for community health promotion. | D Stokols | Am J Health Promot | 1996 | 10159709 | No |
| 2334 | 1522 | 1522.0 | 58.8 | 58.8 | Enhancing the quality and credibility of qualitative analysis. | M Q Patton | Health Serv Res | 1999 | 10591279 | No |
| 2335 | 1522 | 1522.0 | 0.0 | 0.0 | Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. | K Fuxe | Acta Physiol Scand Suppl | 1965 | 14319769 | Yes |
| 2336 | 1522 | 1522.0 | 0.0 | 0.0 | The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. | O V Batson | Ann Surg | 1940 | 17857618 | Yes |
| 2337 | 1522 | 1522.0 | 34.9 | 34.9 | Tumour necrosis factor and cancer. | Frances Balkwill | Nat Rev Cancer | 2009 | 19343034 | No |
| 2338 | 3041 | 1520.5 | 77.1 | 38.5 | Powering the planet: chemical challenges in solar energy utilization. | Nathan S Lewis, Daniel G Nocera | Proc Natl Acad Sci U S A | 2006 | 17043226 | Yes |
| 2339 | 3037 | 1518.5 | 73.1 | 36.5 | Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. | Subhra K Biswas, Alberto Mantovani | Nat Immunol | 2010 | 20856220 | No |
| 2340 | 1518 | 1518.0 | 39.2 | 39.2 | Trophic factors and neuronal survival. | Y A Barde | Neuron | 1989 | 2697237 | No |
| 2341 | 1518 | 1518.0 | 38.4 | 38.4 | Oxidative stress in Parkinson's disease. | Peter Jenner | Ann Neurol | 2003 | 12666096 | No |
| 2342 | 1518 | 1518.0 | 0.0 | 0.0 | Modality and topographic properties of single neurons of cat's somatic sensory cortex. | V B Mountcastle | J Neurophysiol | 1957 | 13439410 | Yes |
| 2343 | 1518 | 1518.0 | 38.0 | 38.0 | What is a support vector machine? | William S Noble | Nat Biotechnol | 2006 | 17160063 | No |
| 2344 | 3034 | 1517.0 | 92.8 | 46.4 | Chlorophyll fluorescence--a practical guide. | K Maxwell, G N Johnson | J Exp Bot | 2000 | 10938857 | No |
| 2345 | 1517 | 1517.0 | 39.0 | 39.0 | TNF-mediated inflammatory disease. | J R Bradley | J Pathol | 2008 | 18161752 | No |
| 2346 | 7583 | 1516.6 | 306.1 | 61.2 | Evidence based medicine: what it is and what it isn't. | D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson | BMJ | 1996 | 8555924 | No |
| 2347 | 1516 | 1516.0 | 39.6 | 39.6 | Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. | H S Penefsky | J Biol Chem | 1977 | 16006 | Yes |
| 2348 | 1516 | 1516.0 | 46.6 | 46.6 | Isolated removal of hypothalamic or other brain nuclei of the rat. | M Palkovits | Brain Res | 1973 | 4747772 | Yes |
| 2349 | 1516 | 1516.0 | 51.0 | 51.0 | Polycystic ovary syndrome. | S Franks | N Engl J Med | 1995 | 7651477 | No |
| 2350 | 1515 | 1515.0 | 49.7 | 49.7 | The functional gastrointestinal disorders and the Rome III process. | Douglas A Drossman | Gastroenterology | 2006 | 16678553 | No |
| 2351 | 1515 | 1515.0 | 59.7 | 59.7 | The evolving concept of health literacy. | Don Nutbeam | Soc Sci Med | 2008 | 18952344 | Yes |
| 2352 | 3029 | 1514.5 | 97.1 | 48.5 | Liquid phase condensation in cell physiology and disease. | Yongdae Shin, Clifford P Brangwynne | Science | 2017 | 28935776 | No |
| 2353 | 1514 | 1514.0 | 40.5 | 40.5 | Optimal foraging, the marginal value theorem. | E L Charnov | Theor Popul Biol | 1976 | 1273796 | Yes |
| 2354 | 1514 | 1514.0 | 0.0 | 0.0 | The perceptron: a probabilistic model for information storage and organization in the brain. | F Rosenblatt | Psychol Rev | 1958 | 13602029 | Yes |
| 2355 | 1514 | 1514.0 | 0.0 | 0.0 | An approximate distribution of estimates of variance components. | F E Satterthwaite | Biometrics | 1946 | 20287815 | Yes |
| 2356 | 1514 | 1514.0 | 41.9 | 41.9 | Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. | Russell Lande | Evolution | 1979 | 28568194 | Yes |
| 2357 | 3027 | 1513.5 | 59.7 | 29.9 | Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. | P J Mitchell, R Tjian | Science | 1989 | 2667136 | No |
| 2358 | 1513 | 1513.0 | 39.0 | 39.0 | Stability of proteins: small globular proteins. | P L Privalov | Adv Protein Chem | 1979 | 44431 | No |
| 2359 | 1513 | 1513.0 | 34.8 | 34.8 | Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. | M B Luskin | Neuron | 1993 | 8338665 | Yes |
| 2360 | 1513 | 1513.0 | 45.7 | 45.7 | Function and information content of DNA methylation. | Dirk Schubeler | Nature | 2015 | 25592537 | No |
| 2361 | 3024 | 1512.0 | 97.7 | 48.9 | Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. | Aluisio J D Barros, Vania N Hirakata | BMC Med Res Methodol | 2003 | 14567763 | Yes |
| 2362 | 1510 | 1510.0 | 0.0 | 0.0 | Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. | R W Sperry | Proc Natl Acad Sci U S A | 1963 | 14077501 | Yes |
| 2363 | 1510 | 1510.0 | 46.0 | 46.0 | Recent developments in isocyanide based multicomponent reactions in applied chemistry. | Alexander Domling | Chem Rev | 2006 | 16402771 | No |
| 2364 | 1510 | 1510.0 | 42.9 | 42.9 | Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. | Felix Kratz | J Control Release | 2008 | 18582981 | No |
| 2365 | 1510 | 1510.0 | 59.0 | 59.0 | How neuroinflammation contributes to neurodegeneration. | Richard M Ransohoff | Science | 2016 | 27540165 | No |
| 2366 | 1509 | 1509.0 | 44.5 | 44.5 | Superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1975 | 1094908 | No |
| 2367 | 1509 | 1509.0 | 51.5 | 51.5 | Myeloid-Derived Suppressor Cells. | Dmitry I Gabrilovich | Cancer Immunol Res | 2017 | 28052991 | No |
| 2368 | 1508 | 1508.0 | 0.0 | 0.0 | The mechanism of muscular contraction. | H E Huxley | Science | 1969 | 4181952 | No |
| 2369 | 3015 | 1507.5 | 0.0 | 0.0 | Lactic dehydrogenase activity in blood. | F Wroblewski, J S Ladue | Proc Soc Exp Biol Med | 1955 | 13273400 | Yes |
| 2370 | 1507 | 1507.0 | 57.3 | 57.3 | How stigma interferes with mental health care. | Patrick Corrigan | Am Psychol | 2004 | 15491256 | Yes |
| 2371 | 4520 | 1506.7 | 102.9 | 34.3 | Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. | Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen | Science | 2005 | 15831717 | Yes |
| 2372 | 3013 | 1506.5 | 96.1 | 48.0 | The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. | W R Gibb, A J Lees | J Neurol Neurosurg Psychiatry | 1988 | 2841426 | No |
| 2373 | 1506 | 1506.0 | 36.1 | 36.1 | Microbial ecology of the gastrointestinal tract. | D C Savage | Annu Rev Microbiol | 1977 | 334036 | No |
| 2374 | 1506 | 1506.0 | 0.0 | 0.0 | The colorimetric determination of phosphorus. | E J King | Biochem J | 1932 | 16744823 | Yes |
| 2375 | 1505 | 1505.0 | 34.0 | 34.0 | Tumor suppressor genes. | R A Weinberg | Science | 1991 | 1659741 | No |
| 2376 | 10535 | 1505.0 | 425.7 | 60.8 | Development and validation of a geriatric depression screening scale: a preliminary report. | J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer | J Psychiatr Res | 1982 | 7183759 | Yes |
| 2377 | 3008 | 1504.0 | 121.1 | 60.5 | Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. | L F Berkman, S L Syme | Am J Epidemiol | 1979 | 425958 | Yes |
| 2378 | 1504 | 1504.0 | 44.6 | 44.6 | Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. | M D Maines | FASEB J | 1988 | 3290025 | No |
| 2379 | 1504 | 1504.0 | 47.0 | 47.0 | Colorimetric determination of phospholipids with ammonium ferrothiocyanate. | J C Stewart | Anal Biochem | 1980 | 6892980 | Yes |
| 2380 | 1504 | 1504.0 | 41.3 | 41.3 | The human orbitofrontal cortex: linking reward to hedonic experience. | Morten L Kringelbach | Nat Rev Neurosci | 2005 | 16136173 | No |
| 2381 | 7516 | 1503.2 | 243.5 | 48.7 | CD-HIT: accelerated for clustering the next-generation sequencing data. | Limin Fu, Beifang Niu, Zhengwei Zhu, Sitao Wu, Weizhong Li | Bioinformatics | 2012 | 23060610 | Yes |
| 2382 | 1502 | 1502.0 | 50.3 | 50.3 | The structure of beta-lactamases. | R P Ambler | Philos Trans R Soc Lond B Biol Sci | 1980 | 6109327 | Yes |
| 2383 | 3004 | 1502.0 | 64.2 | 32.1 | Chemokines: a new classification system and their role in immunity. | A Zlotnik, O Yoshie | Immunity | 2000 | 10714678 | No |
| 2384 | 4506 | 1502.0 | 105.9 | 35.3 | OrthoMCL: identification of ortholog groups for eukaryotic genomes. | Li Li, Christian J Stoeckert, David S Roos | Genome Res | 2003 | 12952885 | Yes |
| 2385 | 1502 | 1502.0 | 36.1 | 36.1 | The cancer stem cell: premises, promises and challenges. | Hans Clevers | Nat Med | 2011 | 21386835 | No |
| 2386 | 1500 | 1500.0 | 41.8 | 41.8 | Rheumatoid arthritis. Pathophysiology and implications for therapy. | E D Harris | N Engl J Med | 1990 | 2271017 | No |
| 2387 | 1500 | 1500.0 | 55.4 | 55.4 | Lyme disease. | A C Steere | N Engl J Med | 1989 | 2668764 | No |
| 2388 | 1500 | 1500.0 | 40.1 | 40.1 | The complex role of estrogens in inflammation. | Rainer H Straub | Endocr Rev | 2007 | 17640948 | No |
| 2389 | 2999 | 1499.5 | 85.6 | 42.8 | The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. | W L Jorgensen, J Tirado-Rives | J Am Chem Soc | 1988 | 27557051 | Yes |
| 2390 | 14985 | 1498.5 | 588.4 | 58.8 | MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. | Fredrik Ronquist, Maxim Teslenko, Paul Van Der Mark, Daniel L Ayres, Aaron Darling, Sebastian Hohna, Bret Larget, Liang Liu, Marc A Suchard, John P Huelsenbeck | Syst Biol | 2012 | 22357727 | Yes |
| 2391 | 8991 | 1498.5 | 331.6 | 55.3 | Second-generation PLINK: rising to the challenge of larger and richer datasets. | Christopher C Chang, Carson C Chow, Laurent Cam Tellier, Shashaank Vattikuti, Shaun M Purcell, James J Lee | Gigascience | 2015 | 25722852 | Yes |
| 2392 | 2996 | 1498.0 | 98.9 | 49.5 | bold: The Barcode of Life Data System (http://www.barcodinglife.org). | Sujeevan Ratnasingham, Paul D N Hebert | Mol Ecol Notes | 2007 | 18784790 | Yes |
| 2393 | 2994 | 1497.0 | 77.8 | 38.9 | Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. | I Issemann, S Green | Nature | 1990 | 2129546 | Yes |
| 2394 | 1497 | 1497.0 | 0.0 | 0.0 | Dopamine (3-hydroxytyramine) and brain function. | O Hornykiewicz | Pharmacol Rev | 1966 | 5328389 | No |
| 2395 | 1497 | 1497.0 | 33.6 | 33.6 | Neurotrophins as synaptic modulators. | M M Poo | Nat Rev Neurosci | 2001 | 11253356 | No |
| 2396 | 2994 | 1497.0 | 132.5 | 66.2 | New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. | Anushka Dongre, Robert A Weinberg | Nat Rev Mol Cell Biol | 2019 | 30459476 | No |
| 2397 | 2993 | 1496.5 | 90.4 | 45.2 | Relaxing the rule of ten events per variable in logistic and Cox regression. | Eric Vittinghoff, Charles E McCulloch | Am J Epidemiol | 2007 | 17182981 | Yes |
| 2398 | 1496 | 1496.0 | 56.0 | 56.0 | Sensorimotor integration in human postural control. | R J Peterka | J Neurophysiol | 2002 | 12205132 | Yes |
| 2399 | 1496 | 1496.0 | 44.8 | 44.8 | Cytokinesis-block micronucleus cytome assay. | Michael Fenech | Nat Protoc | 2007 | 17546000 | Yes |
| 2400 | 1496 | 1496.0 | 35.9 | 35.9 | Non-Smad pathways in TGF-beta signaling. | Ying E Zhang | Cell Res | 2009 | 19114990 | No |
| 2401 | 4487 | 1495.7 | 106.3 | 35.4 | Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. | Christian W Tornoe, Caspar Christensen, Morten Meldal | J Org Chem | 2002 | 11975567 | Yes |
| 2402 | 1495 | 1495.0 | 34.5 | 34.5 | The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. | M Takeichi | Development | 1988 | 3048970 | No |
| 2403 | 1495 | 1495.0 | 84.3 | 84.3 | A comparison of canal preparations in straight and curved root canals. | S W Schneider | Oral Surg Oral Med Oral Pathol | 1971 | 5284110 | Yes |
| 2404 | 2990 | 1495.0 | 66.5 | 33.2 | Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. | S W Hell, J Wichmann | Opt Lett | 1994 | 19844443 | Yes |
| 2405 | 1495 | 1495.0 | 0.0 | 0.0 | Potential, Impedance, And Rectification In Membranes. | D E Goldman | J Gen Physiol | 1943 | 19873371 | Yes |
| 2406 | 2989 | 1494.5 | 78.6 | 39.3 | Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects. | R P Rao, D H Ballard | Nat Neurosci | 1999 | 10195184 | Yes |
| 2407 | 2989 | 1494.5 | 76.8 | 38.4 | Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. | H Cai, D G Harrison | Circ Res | 2000 | 11073878 | No |
| 2408 | 2988 | 1494.0 | 101.1 | 50.5 | The efficiency of systematic sampling in stereology and its prediction. | H J Gundersen, E B Jensen | J Microsc | 1987 | 3430576 | Yes |
| 2409 | 1494 | 1494.0 | 62.9 | 62.9 | Human cardiovascular adjustments to exercise and thermal stress. | L B Rowell | Physiol Rev | 1974 | 4587247 | No |
| 2410 | 1493 | 1493.0 | 34.6 | 34.6 | The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. | R G Khalifah | J Biol Chem | 1971 | 4994926 | Yes |
| 2411 | 1493 | 1493.0 | 0.0 | 0.0 | Defective repair replication of DNA in xeroderma pigmentosum. | J E Cleaver | Nature | 1968 | 5655953 | Yes |
| 2412 | 2985 | 1492.5 | 129.2 | 64.6 | Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. | R Vilgalys, M Hester | J Bacteriol | 1990 | 2376561 | Yes |
| 2413 | 1492 | 1492.0 | 41.3 | 41.3 | Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. | Y Shai | Biochim Biophys Acta | 1999 | 10590302 | No |
| 2414 | 4475 | 1491.7 | 117.6 | 39.2 | LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. | A C Wallace, R A Laskowski, J M Thornton | Protein Eng | 1995 | 7630882 | Yes |
| 2415 | 4475 | 1491.7 | 0.0 | 0.0 | The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. | J T Dodge, C Mitchell, D J Hanahan | Arch Biochem Biophys | 1963 | 14028302 | Yes |
| 2416 | 2982 | 1491.0 | 89.0 | 44.5 | Antibiotic resistance of bacteria in biofilms. | P S Stewart, J W Costerton | Lancet | 2001 | 11463434 | No |
| 2417 | 1491 | 1491.0 | 31.5 | 31.5 | Human natural killer cells. | Michael A Caligiuri | Blood | 2008 | 18650461 | No |
| 2418 | 5964 | 1491.0 | 164.6 | 41.1 | AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. | Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan | Nat Cell Biol | 2011 | 21258367 | Yes |
| 2419 | 1491 | 1491.0 | 39.5 | 39.5 | T follicular helper cell differentiation, function, and roles in disease. | Shane Crotty | Immunity | 2014 | 25367570 | No |
| 2420 | 2981 | 1490.5 | 72.7 | 36.4 | Regulation mechanisms and signaling pathways of autophagy. | Congcong He, Daniel J Klionsky | Annu Rev Genet | 2009 | 19653858 | No |
| 2421 | 1490 | 1490.0 | 43.5 | 43.5 | Mate selection-a selection for a handicap. | A Zahavi | J Theor Biol | 1975 | 1195756 | Yes |
| 2422 | 1490 | 1490.0 | 41.3 | 41.3 | Redox signaling: nitrosylation and related target interactions of nitric oxide. | J S Stamler | Cell | 1994 | 7923362 | No |
| 2423 | 1490 | 1490.0 | 34.1 | 34.1 | Target-oriented and diversity-oriented organic synthesis in drug discovery. | S L Schreiber | Science | 2000 | 10720315 | No |
| 2424 | 1489 | 1489.0 | 108.6 | 108.6 | The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. | F C Ewald | Clin Orthop Relat Res | 1989 | 2805502 | Yes |
| 2425 | 1489 | 1489.0 | 39.9 | 39.9 | The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. | A S Fauci | Science | 1988 | 3277274 | No |
| 2426 | 1489 | 1489.0 | 34.3 | 34.3 | Protein misfolding, evolution and disease. | C M Dobson | Trends Biochem Sci | 1999 | 10470028 | No |
| 2427 | 1489 | 1489.0 | 45.6 | 45.6 | Thermal properties of graphene and nanostructured carbon materials. | Alexander A Balandin | Nat Mater | 2011 | 21778997 | Yes |
| 2428 | 5955 | 1488.8 | 192.0 | 48.0 | A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. | M A Markwell, S M Haas, L L Bieber, N E Tolbert | Anal Biochem | 1978 | 98070 | Yes |
| 2429 | 2976 | 1488.0 | 61.5 | 30.8 | Prediction of complete gene structures in human genomic DNA. | C Burge, S Karlin | J Mol Biol | 1997 | 9149143 | Yes |
| 2430 | 1488 | 1488.0 | 44.8 | 44.8 | A note on robust variance estimation for cluster-correlated data. | R L Williams | Biometrics | 2000 | 10877330 | Yes |
| 2431 | 1488 | 1488.0 | 46.9 | 46.9 | Targeting recovery: priorities of the spinal cord-injured population. | Kim D Anderson | J Neurotrauma | 2004 | 15672628 | Yes |
| 2432 | 1487 | 1487.0 | 33.6 | 33.6 | Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. | C Taswell | J Immunol | 1981 | 7009746 | Yes |
| 2433 | 1487 | 1487.0 | 54.0 | 54.0 | The biology and function of exosomes in cancer. | Raghu Kalluri | J Clin Invest | 2016 | 27035812 | No |
| 2434 | 1487 | 1487.0 | 99.2 | 99.2 | A Review of Coronavirus Disease-2019 (COVID-19). | Tanu Singhal | Indian J Pediatr | 2020 | 32166607 | No |
| 2435 | 13381 | 1486.8 | 418.2 | 46.5 | The 1982 revised criteria for the classification of systemic lupus erythematosus. | E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester | Arthritis Rheum | 1982 | 7138600 | Yes |
| 2436 | 1486 | 1486.0 | 0.0 | 0.0 | Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. | H E Huxley | J Mol Biol | 1963 | 14064165 | Yes |
| 2437 | 2972 | 1486.0 | 74.7 | 37.4 | The ubiquitin code. | David Komander, Michael Rape | Annu Rev Biochem | 2012 | 22524316 | No |
| 2438 | 1486 | 1486.0 | 73.6 | 73.6 | The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. | Martins Ekor | Front Pharmacol | 2014 | 24454289 | No |
| 2439 | 1486 | 1486.0 | 73.9 | 73.9 | Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design. | Nicholas A Meanwell | J Med Chem | 2018 | 29400967 | No |
| 2440 | 2971 | 1485.5 | 59.5 | 29.8 | Missing pieces in the NF-kappaB puzzle. | Sankar Ghosh, Michael Karin | Cell | 2002 | 11983155 | No |
| 2441 | 1485 | 1485.0 | 38.9 | 38.9 | Cell and environment interactions in tumor microregions: the multicell spheroid model. | R M Sutherland | Science | 1988 | 2451290 | Yes |
| 2442 | 1485 | 1485.0 | 0.0 | 0.0 | Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. | S Avrameas | Immunochemistry | 1969 | 4975324 | Yes |
| 2443 | 1484 | 1484.0 | 36.2 | 36.2 | PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. | B M Spiegelman | Diabetes | 1998 | 9568680 | No |
| 2444 | 2968 | 1484.0 | 58.5 | 29.2 | Cancer genes and the pathways they control. | Bert Vogelstein, Kenneth W Kinzler | Nat Med | 2004 | 15286780 | No |
| 2445 | 4451 | 1483.7 | 170.1 | 56.7 | Structure-antioxidant activity relationships of flavonoids and phenolic acids. | C A Rice-Evans, N J Miller, G Paganga | Free Radic Biol Med | 1996 | 8743980 | Yes |
| 2446 | 2967 | 1483.5 | 81.1 | 40.5 | Selective loss of central cholinergic neurons in Alzheimer's disease. | P Davies, A J Maloney | Lancet | 1976 | 63862 | Yes |
| 2447 | 4450 | 1483.3 | 126.1 | 42.0 | Bacterial biofilms: from the natural environment to infectious diseases. | Luanne Hall-Stoodley, J William Costerton, Paul Stoodley | Nat Rev Microbiol | 2004 | 15040259 | No |
| 2448 | 1483 | 1483.0 | 0.0 | 0.0 | Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. | P C Nowell | Cancer Res | 1960 | 14427849 | Yes |
| 2449 | 2966 | 1483.0 | 112.5 | 56.2 | MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets. | Martin Steinegger, Johannes Soding | Nat Biotechnol | 2017 | 29035372 | Yes |
| 2450 | 2965 | 1482.5 | 75.9 | 38.0 | The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. | Daniel J Drucker, Michael A Nauck | Lancet | 2006 | 17098089 | No |
| 2451 | 7412 | 1482.4 | 235.4 | 47.1 | Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939839 | Yes |
| 2452 | 17782 | 1481.8 | 501.6 | 41.8 | Frailty in older adults: evidence for a phenotype. | L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnie, | J Gerontol A Biol Sci Med Sci | 2001 | 11253156 | Yes |
| 2453 | 4445 | 1481.7 | 98.7 | 32.9 | Multidrug resistance in cancer: role of ATP-dependent transporters. | Michael M Gottesman, Tito Fojo, Susan E Bates | Nat Rev Cancer | 2002 | 11902585 | No |
| 2454 | 1481 | 1481.0 | 42.8 | 42.8 | Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. | J A Beavo | Physiol Rev | 1995 | 7480160 | No |
| 2455 | 1481 | 1481.0 | 45.9 | 45.9 | Neural simulation of action: a unifying mechanism for motor cognition. | M Jeannerod | Neuroimage | 2001 | 11373140 | No |
| 2456 | 1481 | 1481.0 | 77.1 | 77.1 | Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges. | Dimitrios Tsikas | Anal Biochem | 2017 | 27789233 | No |
| 2457 | 2960 | 1480.0 | 71.2 | 35.6 | The MAPK signaling cascade. | R Seger, E G Krebs | FASEB J | 1995 | 7601337 | No |
| 2458 | 2960 | 1480.0 | 83.2 | 41.6 | The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. | Clay B Holroyd, Michael G H Coles | Psychol Rev | 2002 | 12374324 | Yes |
| 2459 | 1480 | 1480.0 | 0.0 | 0.0 | A modified ninhydrin colorimetric analysis for amino acids. | H Rosen | Arch Biochem Biophys | 1957 | 13412116 | Yes |
| 2460 | 4438 | 1479.3 | 95.4 | 31.8 | The versatility and universality of calcium signalling. | M J Berridge, P Lipp, M D Bootman | Nat Rev Mol Cell Biol | 2000 | 11413485 | No |
| 2461 | 4438 | 1479.3 | 124.8 | 41.6 | Nitric oxide and peroxynitrite in health and disease. | Pal Pacher, Joseph S Beckman, Lucas Liaudet | Physiol Rev | 2007 | 17237348 | No |
| 2462 | 2958 | 1479.0 | 0.0 | 0.0 | Brain stem reticular formation and activation of the EEG. | G Moruzzi, H W Magoun | Electroencephalogr Clin Neurophysiol | 1949 | 18421835 | Yes |
| 2463 | 2956 | 1478.0 | 55.2 | 27.6 | T-cell antigen receptor genes and T-cell recognition. | M M Davis, P J Bjorkman | Nature | 1988 | 3043226 | No |
| 2464 | 2956 | 1478.0 | 58.5 | 29.2 | Wnt signalling in stem cells and cancer. | Tannishtha Reya, Hans Clevers | Nature | 2005 | 15829953 | No |
| 2465 | 2955 | 1477.5 | 60.4 | 30.2 | Of mice and not men: differences between mouse and human immunology. | Javier Mestas, Christopher C W Hughes | J Immunol | 2004 | 14978070 | No |
| 2466 | 2954 | 1477.0 | 88.2 | 44.1 | Unidentified curved bacilli on gastric epithelium in active chronic gastritis. | J R Warren, B Marshall | Lancet | 1983 | 6134060 | Yes |
| 2467 | 2953 | 1476.5 | 114.0 | 57.0 | Natural products as sources of new drugs over the 30 years from 1981 to 2010. | David J Newman, Gordon M Cragg | J Nat Prod | 2012 | 22316239 | No |
| 2468 | 1476 | 1476.0 | 71.8 | 71.8 | SARS-CoV-2 vaccines in development. | Florian Krammer | Nature | 2020 | 32967006 | No |
| 2469 | 5902 | 1475.5 | 221.4 | 55.4 | Bayesian phylogenetics with BEAUti and the BEAST 1.7. | Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut | Mol Biol Evol | 2012 | 22367748 | Yes |
| 2470 | 2950 | 1475.0 | 101.8 | 50.9 | Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. | D Filmer, L H Pritchett | Demography | 2001 | 11227840 | Yes |
| 2471 | 2950 | 1475.0 | 0.0 | 0.0 | The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. | E G Gray, V P Whittaker | J Anat | 1962 | 13901297 | Yes |
| 2472 | 8849 | 1474.8 | 234.7 | 39.1 | An obesity-associated gut microbiome with increased capacity for energy harvest. | Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon | Nature | 2006 | 17183312 | Yes |
| 2473 | 8848 | 1474.7 | 246.2 | 41.0 | A default mode of brain function. | M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman | Proc Natl Acad Sci U S A | 2001 | 11209064 | Yes |
| 2474 | 1474 | 1474.0 | 49.4 | 49.4 | Chronic disease management: what will it take to improve care for chronic illness? | E H Wagner | Eff Clin Pract | 1998 | 10345255 | No |
| 2475 | 5893 | 1473.2 | 209.9 | 52.5 | Predicting effective microRNA target sites in mammalian mRNAs. | Vikram Agarwal, George W Bell, Jin-Wu Nam, David P Bartel | Elife | 2015 | 26267216 | Yes |
| 2476 | 2946 | 1473.0 | 64.9 | 32.5 | A general method for isolation of high molecular weight DNA from eukaryotes. | N Blin, D W Stafford | Nucleic Acids Res | 1976 | 987581 | Yes |
| 2477 | 1473 | 1473.0 | 33.3 | 33.3 | Ionic blockage of sodium channels in nerve. | A M Woodhull | J Gen Physiol | 1973 | 4541078 | Yes |
| 2478 | 8838 | 1473.0 | 278.7 | 46.4 | Prodigal: prokaryotic gene recognition and translation initiation site identification. | Doug Hyatt, Gwo-Liang Chen, Philip F Locascio, Miriam L Land, Frank W Larimer, Loren J Hauser | BMC Bioinformatics | 2010 | 20211023 | Yes |
| 2479 | 2945 | 1472.5 | 73.2 | 36.6 | Inflammation, stress, and diabetes. | Kathryn E Wellen, Gokhan S Hotamisligil | J Clin Invest | 2005 | 15864338 | No |
| 2480 | 8832 | 1472.0 | 240.9 | 40.1 | Genome engineering using the CRISPR-Cas9 system. | F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng Zhang | Nat Protoc | 2013 | 24157548 | Yes |
| 2481 | 5888 | 1472.0 | 291.5 | 72.9 | The Cambridge Structural Database. | Colin R Groom, Ian J Bruno, Matthew P Lightfoot, Suzanna C Ward | Acta Crystallogr B Struct Sci Cryst Eng Mater | 2016 | 27048719 | Yes |
| 2482 | 10303 | 1471.9 | 672.3 | 96.0 | IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era. | Bui Quang Minh, Heiko A Schmidt, Olga Chernomor, Dominik Schrempf, Michael D Woodhams, Arndt Von Haeseler, Robert Lanfear | Mol Biol Evol | 2020 | 32011700 | Yes |
| 2483 | 1471 | 1471.0 | 0.0 | 0.0 | A clinical method for assessing the ventilatory response to carbon dioxide. | D J Read | Australas Ann Med | 1967 | 6032026 | Yes |
| 2484 | 1471 | 1471.0 | 33.5 | 33.5 | The ATP synthase--a splendid molecular machine. | P D Boyer | Annu Rev Biochem | 1997 | 9242922 | No |
| 2485 | 1471 | 1471.0 | 27.5 | 27.5 | The DNA methyltransferases of mammals. | T H Bestor | Hum Mol Genet | 2000 | 11005794 | No |
| 2486 | 1471 | 1471.0 | 57.0 | 57.0 | Starting at the beginning: an introduction to coefficient alpha and internal consistency. | David L Streiner | J Pers Assess | 2003 | 12584072 | Yes |
| 2487 | 1471 | 1471.0 | 0.0 | 0.0 | The free amino groups of insulin. | F Sanger | Biochem J | 1945 | 16747948 | Yes |
| 2488 | 2942 | 1471.0 | 82.0 | 41.0 | New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. | Jonathan B Baell, Georgina A Holloway | J Med Chem | 2010 | 20131845 | Yes |
| 2489 | 1471 | 1471.0 | 60.7 | 60.7 | Likert scales, levels of measurement and the "laws" of statistics. | Geoff Norman | Adv Health Sci Educ Theory Pract | 2010 | 20146096 | Yes |
| 2490 | 2942 | 1471.0 | 110.7 | 55.4 | AKT/PKB Signaling: Navigating the Network. | Brendan D Manning, Alex Toker | Cell | 2017 | 28431241 | No |
| 2491 | 1470 | 1470.0 | 0.0 | 0.0 | Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. | K S McCully | Am J Pathol | 1969 | 5792556 | Yes |
| 2492 | 1470 | 1470.0 | 34.6 | 34.6 | Diarylethenes for Memories and Switches. | Masahiro Irie | Chem Rev | 2000 | 11777416 | Yes |
| 2493 | 2940 | 1470.0 | 65.0 | 32.5 | LTP and LTD: an embarrassment of riches. | Robert C Malenka, Mark F Bear | Neuron | 2004 | 15450156 | No |
| 2494 | 4410 | 1470.0 | 146.4 | 48.8 | Global estimates of the prevalence of diabetes for 2010 and 2030. | J E Shaw, R A Sicree, P Z Zimmet | Diabetes Res Clin Pract | 2010 | 19896746 | Yes |
| 2495 | 1469 | 1469.0 | 29.8 | 29.8 | Natively unfolded proteins: a point where biology waits for physics. | Vladimir N Uversky | Protein Sci | 2002 | 11910019 | No |
| 2496 | 1468 | 1468.0 | 42.0 | 42.0 | The aging process. | D Harman | Proc Natl Acad Sci U S A | 1981 | 6947277 | Yes |
| 2497 | 1468 | 1468.0 | 33.7 | 33.7 | Transcriptional control of adipocyte formation. | Stephen R Farmer | Cell Metab | 2006 | 17011499 | No |
| 2498 | 4403 | 1467.7 | 136.0 | 45.3 | TCS: a computer program to estimate gene genealogies. | M Clement, D Posada, K A Crandall | Mol Ecol | 2000 | 11050560 | Yes |
| 2499 | 1467 | 1467.0 | 50.0 | 50.0 | The epidemiology of adult obstructive sleep apnea. | Naresh M Punjabi | Proc Am Thorac Soc | 2008 | 18250205 | No |
| 2500 | 4398 | 1466.0 | 216.5 | 72.2 | Risk factors for falls among elderly persons living in the community. | M E Tinetti, M Speechley, S F Ginter | N Engl J Med | 1988 | 3205267 | Yes |
| 2501 | 2932 | 1466.0 | 92.9 | 46.5 | The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. | J D Hayes, D J Pulford | Crit Rev Biochem Mol Biol | 1995 | 8770536 | No |
| 2502 | 1466 | 1466.0 | 44.6 | 44.6 | Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. | Chao-Jun Li | Acc Chem Res | 2009 | 19220064 | Yes |
| 2503 | 1466 | 1466.0 | 70.2 | 70.2 | Patient reported outcome measures could help transform healthcare. | Nick Black | BMJ | 2013 | 23358487 | Yes |
| 2504 | 2932 | 1466.0 | 130.7 | 65.3 | Principal component analysis: a review and recent developments. | Ian T Jolliffe, Jorge Cadima | Philos Trans A Math Phys Eng Sci | 2016 | 26953178 | No |
| 2505 | 2931 | 1465.5 | 86.2 | 43.1 | Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. | F D Lublin, S C Reingold | Neurology | 1996 | 8780061 | Yes |
| 2506 | 2931 | 1465.5 | 57.5 | 28.8 | STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. | Hiroki Ishikawa, Glen N Barber | Nature | 2008 | 18724357 | Yes |
| 2507 | 1465 | 1465.0 | 64.2 | 64.2 | The clinical application of the biopsychosocial model. | G L Engel | Am J Psychiatry | 1980 | 7369396 | Yes |
| 2508 | 2930 | 1465.0 | 68.5 | 34.2 | The pathophysiology and treatment of sepsis. | Richard S Hotchkiss, Irene E Karl | N Engl J Med | 2003 | 12519925 | No |
| 2509 | 2930 | 1465.0 | 86.5 | 43.2 | Epidemiology of invasive candidiasis: a persistent public health problem. | M A Pfaller, D J Diekema | Clin Microbiol Rev | 2007 | 17223626 | No |
| 2510 | 5859 | 1464.8 | 156.9 | 39.2 | Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. | Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu Miyasaka | J Am Chem Soc | 2009 | 19366264 | Yes |
| 2511 | 5858 | 1464.5 | 252.3 | 63.1 | Prevalence of childhood and adult obesity in the United States, 2011-2012. | Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M Flegal | JAMA | 2014 | 24570244 | Yes |
| 2512 | 1464 | 1464.0 | 29.5 | 29.5 | Nucleic acid junctions and lattices. | N C Seeman | J Theor Biol | 1982 | 6188926 | Yes |
| 2513 | 2928 | 1464.0 | 74.8 | 37.4 | C-reactive protein: a critical update. | Mark B Pepys, Gideon M Hirschfield | J Clin Invest | 2003 | 12813013 | No |
| 2514 | 1464 | 1464.0 | 0.0 | 0.0 | Simple methods for "staining with lead" at high pH in electron microscopy. | M J Karnovsky | J Biophys Biochem Cytol | 1961 | 14454024 | Yes |
| 2515 | 1463 | 1463.0 | 35.9 | 35.9 | Binary Agrobacterium vectors for plant transformation. | M Bevan | Nucleic Acids Res | 1984 | 6095209 | Yes |
| 2516 | 1463 | 1463.0 | 37.1 | 37.1 | Drug-induced prolongation of the QT interval. | Dan M Roden | N Engl J Med | 2004 | 14999113 | No |
| 2517 | 2925 | 1462.5 | 80.3 | 40.1 | The expanding universe of T-cell subsets: Th1, Th2 and more. | T R Mosmann, S Sad | Immunol Today | 1996 | 8820272 | No |
| 2518 | 2923 | 1461.5 | 63.6 | 31.8 | The canonical Notch signaling pathway: unfolding the activation mechanism. | Raphael Kopan, Maria Xenia G Ilagan | Cell | 2009 | 19379690 | No |
| 2519 | 2922 | 1461.0 | 0.0 | 0.0 | Virus interference. I. The interferon. | A Isaacs, J Lindenmann | Proc R Soc Lond B Biol Sci | 1957 | 13465720 | Yes |
| 2520 | 1461 | 1461.0 | 0.0 | 0.0 | Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. | I E Bush | Biochem J | 1952 | 14915960 | Yes |
| 2521 | 1461 | 1461.0 | 43.7 | 43.7 | Endometriosis. | Serdar E Bulun | N Engl J Med | 2009 | 19144942 | No |
| 2522 | 2922 | 1461.0 | 100.7 | 50.4 | Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. | Claudio Franceschi, Judith Campisi | J Gerontol A Biol Sci Med Sci | 2014 | 24833586 | No |
| 2523 | 1461 | 1461.0 | 86.2 | 86.2 | Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. | Jonas F Ludvigsson | Acta Paediatr | 2020 | 32202343 | Yes |
| 2524 | 2921 | 1460.5 | 83.0 | 41.5 | Assay of proteins in the presence of interfering materials. | A Bensadoun, D Weinstein | Anal Biochem | 1976 | 1259145 | Yes |
| 2525 | 1460 | 1460.0 | 0.0 | 0.0 | The origin of the genetic code. | F H Crick | J Mol Biol | 1968 | 4887876 | Yes |
| 2526 | 2920 | 1460.0 | 56.6 | 28.3 | Oncogenic kinase signalling. | P Blume-Jensen, T Hunter | Nature | 2001 | 11357143 | No |
| 2527 | 1460 | 1460.0 | 63.0 | 63.0 | Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. | Daniel J Drucker | Cell Metab | 2018 | 29617641 | No |
| 2528 | 2919 | 1459.5 | 0.0 | 0.0 | Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. | A Dahlstroem, K Fuxe | Acta Physiol Scand Suppl | 1964 | 14229500 | Yes |
| 2529 | 4378 | 1459.3 | 102.7 | 34.2 | Photodynamic therapy for cancer. | Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain | Nat Rev Cancer | 2003 | 12724736 | No |
| 2530 | 1459 | 1459.0 | 42.3 | 42.3 | Isolation and cultivation of Lyme disease spirochetes. | A G Barbour | Yale J Biol Med | 1984 | 6393604 | Yes |
| 2531 | 1459 | 1459.0 | 50.8 | 50.8 | Electrolytes and interphases in Li-ion batteries and beyond. | Kang Xu | Chem Rev | 2014 | 25351820 | Yes |
| 2532 | 2917 | 1458.5 | 111.5 | 55.8 | Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. | Ulrich M Zanger, Matthias Schwab | Pharmacol Ther | 2013 | 23333322 | No |
| 2533 | 1457 | 1457.0 | 34.3 | 34.3 | Developmental cell death: morphological diversity and multiple mechanisms. | P G Clarke | Anat Embryol (Berl) | 1990 | 2186664 | No |
| 2534 | 1457 | 1457.0 | 41.1 | 41.1 | Comparative physiology of salt and water stress. | R Munns | Plant Cell Environ | 2002 | 11841667 | Yes |
| 2535 | 1457 | 1457.0 | 36.9 | 36.9 | A likelihood approach to estimating phylogeny from discrete morphological character data. | P O Lewis | Syst Biol | 2001 | 12116640 | Yes |
| 2536 | 1457 | 1457.0 | 0.0 | 0.0 | The critical incident technique. | J C Flanagan | Psychol Bull | 1954 | 13177800 | Yes |
| 2537 | 2914 | 1457.0 | 72.7 | 36.4 | Microglia: active sensor and versatile effector cells in the normal and pathologic brain. | Uwe-Karsten Hanisch, Helmut Kettenmann | Nat Neurosci | 2007 | 17965659 | No |
| 2538 | 2913 | 1456.5 | 59.9 | 29.9 | 3' non-coding region sequences in eukaryotic messenger RNA. | N J Proudfoot, G G Brownlee | Nature | 1976 | 822353 | Yes |
| 2539 | 2913 | 1456.5 | 127.1 | 63.5 | Cronbach's alpha. | J M Bland, D G Altman | BMJ | 1997 | 9055718 | Yes |
| 2540 | 1456 | 1456.0 | 34.1 | 34.1 | Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. | S S Lehrer | Biochemistry | 1971 | 5119250 | Yes |
| 2541 | 1456 | 1456.0 | 43.3 | 43.3 | The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. | R G Pertwee | Br J Pharmacol | 2008 | 17828291 | No |
| 2542 | 2911 | 1455.5 | 0.0 | 0.0 | Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. | D H Clarke, J Casals | Am J Trop Med Hyg | 1958 | 13571577 | Yes |
| 2543 | 2911 | 1455.5 | 75.6 | 37.8 | Integrins in cancer: biological implications and therapeutic opportunities. | Jay S Desgrosellier, David A Cheresh | Nat Rev Cancer | 2010 | 20029421 | No |
| 2544 | 2910 | 1455.0 | 72.7 | 36.4 | Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. | E S Lander, D Botstein | Genetics | 1989 | 2563713 | Yes |
| 2545 | 1455 | 1455.0 | 0.0 | 0.0 | Hippocampal electrical activity and voluntary movement in the rat. | C H Vanderwolf | Electroencephalogr Clin Neurophysiol | 1969 | 4183562 | Yes |
| 2546 | 2910 | 1455.0 | 69.6 | 34.8 | Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. | E Engvall, P Perlmann | Immunochemistry | 1971 | 5135623 | Yes |
| 2547 | 2909 | 1454.5 | 105.6 | 52.8 | Unique features of long non-coding RNA biogenesis and function. | Jeffrey J Quinn, Howard Y Chang | Nat Rev Genet | 2016 | 26666209 | No |
| 2548 | 2909 | 1454.5 | 337.9 | 168.9 | The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth. | Karin E De Visser, Johanna A Joyce | Cancer Cell | 2023 | 36917948 | No |
| 2549 | 1454 | 1454.0 | 42.4 | 42.4 | The organization of proteins in the human red blood cell membrane. A review. | T L Steck | J Cell Biol | 1974 | 4600883 | No |
| 2550 | 1454 | 1454.0 | 87.0 | 87.0 | Critical Analysis of Strategies for Determining Rigor in Qualitative Inquiry. | Janice M Morse | Qual Health Res | 2015 | 26184336 | Yes |
| 2551 | 1453 | 1453.0 | 56.2 | 56.2 | Presidential address, 1980. Surprise!...Surprise? | E Donchin | Psychophysiology | 1981 | 7280146 | Yes |
| 2552 | 1453 | 1453.0 | 38.3 | 38.3 | Tobacco smoke carcinogens and lung cancer. | S S Hecht | J Natl Cancer Inst | 1999 | 10413421 | No |
| 2553 | 2904 | 1452.0 | 80.5 | 40.2 | A rapid boiling method for the preparation of bacterial plasmids. | D S Holmes, M Quigley | Anal Biochem | 1981 | 6269464 | Yes |
| 2554 | 2903 | 1451.5 | 73.7 | 36.9 | Molecular beacons: probes that fluoresce upon hybridization. | S Tyagi, F R Kramer | Nat Biotechnol | 1996 | 9630890 | Yes |
| 2555 | 2903 | 1451.5 | 60.7 | 30.4 | Learning the parts of objects by non-negative matrix factorization. | D D Lee, H S Seung | Nature | 1999 | 10548103 | Yes |
| 2556 | 2903 | 1451.5 | 87.5 | 43.8 | Opportunities and challenges for a sustainable energy future. | Steven Chu, Arun Majumdar | Nature | 2012 | 22895334 | No |
| 2557 | 2903 | 1451.5 | 85.1 | 42.5 | Mitochondrial fission, fusion, and stress. | Richard J Youle, Alexander M Van Der Bliek | Science | 2012 | 22936770 | No |
| 2558 | 1451 | 1451.0 | 52.8 | 52.8 | Quantitative methods in the review of epidemiologic literature. | S Greenland | Epidemiol Rev | 1987 | 3678409 | Yes |
| 2559 | 10157 | 1451.0 | 313.2 | 44.7 | Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. | H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh | Stroke | 1993 | 7678184 | Yes |
| 2560 | 1451 | 1451.0 | 44.9 | 44.9 | Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. | P Willner | Psychopharmacology (Berl) | 1997 | 9452163 | No |
| 2561 | 2900 | 1450.0 | 82.7 | 41.4 | Angiogenesis. | J Folkman, Y Shing | J Biol Chem | 1992 | 1375931 | No |
| 2562 | 1450 | 1450.0 | 77.8 | 77.8 | Displaced proximal humeral fractures. I. Classification and evaluation. | C S Neer | J Bone Joint Surg Am | 1970 | 5455339 | Yes |
| 2563 | 1450 | 1450.0 | 36.0 | 36.0 | Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? | Rui Wang | FASEB J | 2002 | 12409322 | Yes |
| 2564 | 1450 | 1450.0 | 29.9 | 29.9 | Solving structures of protein complexes by molecular replacement with Phaser. | Airlie J McCoy | Acta Crystallogr D Biol Crystallogr | 2007 | 17164524 | Yes |
| 2565 | 1450 | 1450.0 | 44.3 | 44.3 | Persister cells. | Kim Lewis | Annu Rev Microbiol | 2010 | 20528688 | No |
| 2566 | 1449 | 1449.0 | 36.8 | 36.8 | General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. | R A Houghten | Proc Natl Acad Sci U S A | 1985 | 2410914 | Yes |
| 2567 | 2898 | 1449.0 | 0.0 | 0.0 | Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. | H J Bloom, W W Richardson | Br J Cancer | 1957 | 13499785 | Yes |
| 2568 | 1448 | 1448.0 | 27.2 | 27.2 | Ubiquitin-dependent protein degradation. | M Hochstrasser | Annu Rev Genet | 1996 | 8982460 | No |
| 2569 | 2895 | 1447.5 | 60.4 | 30.2 | Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. | C Auffray, F Rougeon | Eur J Biochem | 1980 | 6772444 | Yes |
| 2570 | 7234 | 1446.8 | 269.3 | 53.9 | The Phyre2 web portal for protein modeling, prediction and analysis. | Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E Sternberg | Nat Protoc | 2015 | 25950237 | Yes |
| 2571 | 2893 | 1446.5 | 184.5 | 92.2 | Facial nerve grading system. | J W House, D E Brackmann | Otolaryngol Head Neck Surg | 1985 | 3921901 | Yes |
| 2572 | 5785 | 1446.2 | 202.7 | 50.7 | The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. | L A Sternberger, P H Hardy, J J Cuculis, H G Meyer | J Histochem Cytochem | 1970 | 4192899 | Yes |
| 2573 | 2892 | 1446.0 | 116.7 | 58.4 | Malondialdehyde determination as index of lipid peroxidation. | H H Draper, M Hadley | Methods Enzymol | 1990 | 2233309 | Yes |
| 2574 | 1446 | 1446.0 | 50.2 | 50.2 | Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. | G A McPherson | J Pharmacol Methods | 1985 | 3840547 | Yes |
| 2575 | 1446 | 1446.0 | 29.2 | 29.2 | Mechanisms of caspase activation and inhibition during apoptosis. | Yigong Shi | Mol Cell | 2002 | 11931755 | No |
| 2576 | 1446 | 1446.0 | 32.1 | 32.1 | A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. | Dale R Nyholt | Am J Hum Genet | 2004 | 14997420 | Yes |
| 2577 | 2892 | 1446.0 | 0.0 | 0.0 | Mutants of Escherichia coli requiring methionine or vitamin B12. | B D Davis, E S Mingioli | J Bacteriol | 1950 | 15436457 | Yes |
| 2578 | 1445 | 1445.0 | 22.6 | 22.6 | Origin of concatemeric T7 DNA. | J D Watson | Nat New Biol | 1972 | 4507727 | Yes |
| 2579 | 1445 | 1445.0 | 53.6 | 53.6 | Plasma perspective on strong field multiphoton ionization. | P B Corkum | Phys Rev Lett | 1993 | 10054556 | Yes |
| 2580 | 1445 | 1445.0 | 46.8 | 46.8 | Understanding diagnostic tests 3: Receiver operating characteristic curves. | Anthony K Akobeng | Acta Paediatr | 2007 | 17376185 | No |
| 2581 | 2889 | 1444.5 | 73.6 | 36.8 | Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. | M D Pierschbacher, E Ruoslahti | Nature | 1984 | 6325925 | Yes |
| 2582 | 2888 | 1444.0 | 72.9 | 36.5 | Quorum sensing in bacteria. | M B Miller, B L Bassler | Annu Rev Microbiol | 2001 | 11544353 | No |
| 2583 | 4332 | 1444.0 | 110.9 | 37.0 | Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. | Daniel Falush, Matthew Stephens, Jonathan K Pritchard | Genetics | 2003 | 12930761 | Yes |
| 2584 | 1443 | 1443.0 | 38.1 | 38.1 | Capacitative calcium entry revisited. | J W Putney | Cell Calcium | 1990 | 1965707 | No |
| 2585 | 1443 | 1443.0 | 20.7 | 20.7 | Central dogma of molecular biology. | F Crick | Nature | 1970 | 4913914 | No |
| 2586 | 2886 | 1443.0 | 77.5 | 38.8 | Therapeutic potential of resveratrol: the in vivo evidence. | Joseph A Baur, David A Sinclair | Nat Rev Drug Discov | 2006 | 16732220 | No |
| 2587 | 1443 | 1443.0 | 68.7 | 68.7 | Embracing the unknown: disentangling the complexities of the soil microbiome. | Noah Fierer | Nat Rev Microbiol | 2017 | 28824177 | No |
| 2588 | 7214 | 1442.8 | 159.1 | 31.8 | Site-directed mutagenesis by overlap extension using the polymerase chain reaction. | S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease | Gene | 1989 | 2744487 | Yes |
| 2589 | 2884 | 1442.0 | 66.2 | 33.1 | The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. | P M Sharp, W H Li | Nucleic Acids Res | 1987 | 3547335 | Yes |
| 2590 | 1442 | 1442.0 | 0.0 | 0.0 | Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. | J Wyman | Adv Protein Chem | 1964 | 14268785 | No |
| 2591 | 1442 | 1442.0 | 27.4 | 27.4 | ChIP-seq: advantages and challenges of a maturing technology. | Peter J Park | Nat Rev Genet | 2009 | 19736561 | No |
| 2592 | 2883 | 1441.5 | 90.5 | 45.2 | Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9164317 | Yes |
| 2593 | 1441 | 1441.0 | 29.9 | 29.9 | Stability and flexibility of epigenetic gene regulation in mammalian development. | Wolf Reik | Nature | 2007 | 17522676 | No |
| 2594 | 2882 | 1441.0 | 86.5 | 43.2 | The Measurement Of Selection On Correlated Characters. | Russell Lande, Stevan J Arnold | Evolution | 1983 | 28556011 | Yes |
| 2595 | 2881 | 1440.5 | 0.0 | 0.0 | A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. | A H Anton, D F Sayre | J Pharmacol Exp Ther | 1962 | 14013351 | Yes |
| 2596 | 1440 | 1440.0 | 49.7 | 49.7 | Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. | N Krieger | Am J Public Health | 1992 | 1566949 | Yes |
| 2597 | 1440 | 1440.0 | 42.9 | 42.9 | Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. | P Lips | Endocr Rev | 2001 | 11493580 | No |
| 2598 | 2880 | 1440.0 | 88.2 | 44.1 | Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. | J A Sterne, M Egger | J Clin Epidemiol | 2001 | 11576817 | Yes |
| 2599 | 1440 | 1440.0 | 36.3 | 36.3 | The use of nanocrystals in biological detection. | Paul Alivisatos | Nat Biotechnol | 2004 | 14704706 | Yes |
| 2600 | 1440 | 1440.0 | 39.9 | 39.9 | Atopic dermatitis. | Thomas Bieber | N Engl J Med | 2008 | 18385500 | Yes |
| 2601 | 1440 | 1440.0 | 49.7 | 49.7 | The frailty syndrome: definition and natural history. | Qian-Li Xue | Clin Geriatr Med | 2011 | 21093718 | No |
| 2602 | 4320 | 1440.0 | 276.5 | 92.2 | How to perform a meta-analysis with R: a practical tutorial. | Sara Balduzzi, Gerta Rucker, Guido Schwarzer | Evid Based Ment Health | 2019 | 31563865 | Yes |
| 2603 | 4318 | 1439.3 | 87.5 | 29.2 | Exosomes: composition, biogenesis and function. | Clotilde Thery, Laurence Zitvogel, Sebastian Amigorena | Nat Rev Immunol | 2002 | 12154376 | No |
| 2604 | 2878 | 1439.0 | 102.0 | 51.0 | Modeling and comparison of dissolution profiles. | P Costa, J M Sousa Lobo | Eur J Pharm Sci | 2001 | 11297896 | No |
| 2605 | 4317 | 1439.0 | 104.1 | 34.7 | Tissue cells feel and respond to the stiffness of their substrate. | Dennis E Discher, Paul Janmey, Yu-Li Wang | Science | 2005 | 16293750 | No |
| 2606 | 1439 | 1439.0 | 0.0 | 0.0 | The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. | R C Lewontin | Genetics | 1964 | 17248194 | Yes |
| 2607 | 2877 | 1438.5 | 73.6 | 36.8 | Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. | M P Lutolf, J A Hubbell | Nat Biotechnol | 2005 | 15637621 | No |
| 2608 | 1438 | 1438.0 | 32.2 | 32.2 | HIF-1: mediator of physiological and pathophysiological responses to hypoxia. | G L Semenza | J Appl Physiol (1985) | 2000 | 10749844 | No |
| 2609 | 1438 | 1438.0 | 34.7 | 34.7 | Metastatic bone disease: clinical features, pathophysiology and treatment strategies. | R E Coleman | Cancer Treat Rev | 2001 | 11417967 | No |
| 2610 | 1438 | 1438.0 | 43.3 | 43.3 | Core affect and the psychological construction of emotion. | James A Russell | Psychol Rev | 2003 | 12529060 | No |
| 2611 | 2876 | 1438.0 | 0.0 | 0.0 | A new scale of social desirability independent of psychopathology. | D P Crowne, D Marlowe | J Consult Psychol | 1960 | 13813058 | Yes |
| 2612 | 1438 | 1438.0 | 39.5 | 39.5 | The sympathetic control of blood pressure. | Patrice G Guyenet | Nat Rev Neurosci | 2006 | 16760914 | No |
| 2613 | 1438 | 1438.0 | 30.6 | 30.6 | Neuroligins and neurexins link synaptic function to cognitive disease. | Thomas C Sudhof | Nature | 2008 | 18923512 | No |
| 2614 | 5752 | 1438.0 | 163.8 | 41.0 | GCTA: a tool for genome-wide complex trait analysis. | Jian Yang, S Hong Lee, Michael E Goddard, Peter M Visscher | Am J Hum Genet | 2011 | 21167468 | Yes |
| 2615 | 1437 | 1437.0 | 25.9 | 25.9 | The snail superfamily of zinc-finger transcription factors. | M Angela Nieto | Nat Rev Mol Cell Biol | 2002 | 11994736 | No |
| 2616 | 1437 | 1437.0 | 0.0 | 0.0 | Starch gel electrophoresis in a discontinous system of buffers. | M D Poulik | Nature | 1957 | 13493570 | Yes |
| 2617 | 1437 | 1437.0 | 32.5 | 32.5 | Simple model of spiking neurons. | E M Izhikevich | IEEE Trans Neural Netw | 2003 | 18244602 | Yes |
| 2618 | 1437 | 1437.0 | 60.8 | 60.8 | Overview of the IL-1 family in innate inflammation and acquired immunity. | Charles A Dinarello | Immunol Rev | 2018 | 29247995 | No |
| 2619 | 5747 | 1436.8 | 160.4 | 40.1 | The metabolic syndrome--a new worldwide definition. | K George M M Alberti, Paul Zimmet, Jonathan Shaw, | Lancet | 2005 | 16182882 | Yes |
| 2620 | 1436 | 1436.0 | 64.2 | 64.2 | Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. | Helmut Sies | Redox Biol | 2017 | 28110218 | No |
| 2621 | 2870 | 1435.0 | 88.2 | 44.1 | Mechanisms of fibrosis: therapeutic translation for fibrotic disease. | Thomas A Wynn, Thirumalai R Ramalingam | Nat Med | 2012 | 22772564 | No |
| 2622 | 1435 | 1435.0 | 67.7 | 67.7 | Body Mass Index: Obesity, BMI, and Health: A Critical Review. | Frank Q Nuttall | Nutr Today | 2015 | 27340299 | Yes |
| 2623 | 4303 | 1434.3 | 114.6 | 38.2 | Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. | S Schulman, C Kearon, | J Thromb Haemost | 2005 | 15842354 | Yes |
| 2624 | 4302 | 1434.0 | 96.4 | 32.1 | NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. | S Ghosh, M J May, E B Kopp | Annu Rev Immunol | 1998 | 9597130 | No |
| 2625 | 1434 | 1434.0 | 34.7 | 34.7 | Physiological and molecular basis of thyroid hormone action. | P M Yen | Physiol Rev | 2001 | 11427693 | No |
| 2626 | 1434 | 1434.0 | 55.2 | 55.2 | A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. | Cathy J Price | Neuroimage | 2012 | 22584224 | No |
| 2627 | 1434 | 1434.0 | 49.3 | 49.3 | Energy metabolism in the liver. | Liangyou Rui | Compr Physiol | 2014 | 24692138 | No |
| 2628 | 4299 | 1433.0 | 144.1 | 48.0 | Vascular endothelial cells synthesize nitric oxide from L-arginine. | R M Palmer, D S Ashton, S Moncada | Nature | 1988 | 3131684 | Yes |
| 2629 | 2866 | 1433.0 | 84.5 | 42.2 | Intracellular pH. | A Roos, W F Boron | Physiol Rev | 1981 | 7012859 | No |
| 2630 | 1433 | 1433.0 | 34.6 | 34.6 | Functions of ceramide in coordinating cellular responses to stress. | Y A Hannun | Science | 1996 | 8943189 | No |
| 2631 | 2865 | 1432.5 | 131.0 | 65.5 | Inflammation and Cancer: Triggers, Mechanisms, and Consequences. | Florian R Greten, Sergei I Grivennikov | Immunity | 2019 | 31315034 | No |
| 2632 | 1432 | 1432.0 | 26.8 | 26.8 | Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. | J C Unkeless | J Exp Med | 1979 | 90108 | Yes |
| 2633 | 2864 | 1432.0 | 0.0 | 0.0 | The effect of sodium ions on the electrical activity of giant axon of the squid. | A L Hodgkin, B Katz | J Physiol | 1949 | 18128147 | Yes |
| 2634 | 4295 | 1431.7 | 129.3 | 43.1 | A rapid bootstrap algorithm for the RAxML Web servers. | Alexandros Stamatakis, Paul Hoover, Jacques Rougemont | Syst Biol | 2008 | 18853362 | Yes |
| 2635 | 7155 | 1431.0 | 138.4 | 27.7 | Crystal structure of the nucleosome core particle at 2.8 A resolution. | K Luger, A W Mader, R K Richmond, D F Sargent, T J Richmond | Nature | 1997 | 9305837 | Yes |
| 2636 | 1431 | 1431.0 | 38.7 | 38.7 | Pain and emotion interactions in subregions of the cingulate gyrus. | Brent A Vogt | Nat Rev Neurosci | 2005 | 15995724 | No |
| 2637 | 1431 | 1431.0 | 34.4 | 34.4 | Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. | Hiroshi Takayanagi | Nat Rev Immunol | 2007 | 17380158 | No |
| 2638 | 2860 | 1430.0 | 82.2 | 41.1 | Transforming growth factor beta in tissue fibrosis. | W A Border, N A Noble | N Engl J Med | 1994 | 7935686 | No |
| 2639 | 1430 | 1430.0 | 26.8 | 26.8 | c-Myc target genes involved in cell growth, apoptosis, and metabolism. | C V Dang | Mol Cell Biol | 1999 | 9858526 | No |
| 2640 | 1430 | 1430.0 | 34.9 | 34.9 | Molecular basis of long-term plasticity underlying addiction. | E J Nestler | Nat Rev Neurosci | 2001 | 11252991 | No |
| 2641 | 1430 | 1430.0 | 41.5 | 41.5 | Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. | P Vestergaard | Osteoporos Int | 2007 | 17068657 | No |
| 2642 | 1430 | 1430.0 | 45.2 | 45.2 | Clinical practice. Endometriosis. | Linda C Giudice | N Engl J Med | 2010 | 20573927 | No |
| 2643 | 1430 | 1430.0 | 46.5 | 46.5 | Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. | Rui Wang | Physiol Rev | 2012 | 22535897 | No |
| 2644 | 1429 | 1429.0 | 27.6 | 27.6 | The biologic clock: the mitochondria? | D Harman | J Am Geriatr Soc | 1972 | 5016631 | Yes |
| 2645 | 1429 | 1429.0 | 34.4 | 34.4 | Regulation of differentiation of vascular smooth muscle cells. | G K Owens | Physiol Rev | 1995 | 7624392 | No |
| 2646 | 1429 | 1429.0 | 39.1 | 39.1 | Persister cells, dormancy and infectious disease. | Kim Lewis | Nat Rev Microbiol | 2007 | 17143318 | No |
| 2647 | 4286 | 1428.7 | 91.5 | 30.5 | Calcium signalling: dynamics, homeostasis and remodelling. | Michael J Berridge, Martin D Bootman, H Llewelyn Roderick | Nat Rev Mol Cell Biol | 2003 | 12838335 | No |
| 2648 | 1428 | 1428.0 | 37.5 | 37.5 | Microbial influences in inflammatory bowel diseases. | R Balfour Sartor | Gastroenterology | 2008 | 18242222 | No |
| 2649 | 2854 | 1427.0 | 95.3 | 47.6 | Performing the exact test of Hardy-Weinberg proportion for multiple alleles. | S W Guo, E A Thompson | Biometrics | 1992 | 1637966 | Yes |
| 2650 | 4280 | 1426.7 | 136.8 | 45.6 | Health benefits of physical activity: the evidence. | Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin | CMAJ | 2006 | 16534088 | No |
| 2651 | 1426 | 1426.0 | 43.5 | 43.5 | Classification of chronic viral hepatitis: a need for reassessment. | P J Scheuer | J Hepatol | 1991 | 1808228 | No |
| 2652 | 1426 | 1426.0 | 39.1 | 39.1 | Deconvoluting the context-dependent role for autophagy in cancer. | Eileen White | Nat Rev Cancer | 2012 | 22534666 | No |
| 2653 | 2851 | 1425.5 | 0.0 | 0.0 | Construct validity in psychological tests. | L J Cronbach, P E Meehl | Psychol Bull | 1955 | 13245896 | Yes |
| 2654 | 2851 | 1425.5 | 76.3 | 38.1 | Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. | Taro Kawai, Shizuo Akira | Immunity | 2011 | 21616434 | No |
| 2655 | 2850 | 1425.0 | 100.1 | 50.0 | Total energy intake: implications for epidemiologic analyses. | W Willett, M J Stampfer | Am J Epidemiol | 1986 | 3521261 | No |
| 2656 | 1425 | 1425.0 | 30.7 | 30.7 | Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. | R I Morimoto | Genes Dev | 1998 | 9869631 | No |
| 2657 | 1425 | 1425.0 | 40.7 | 40.7 | The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. | T Szkudelski | Physiol Res | 2001 | 11829314 | No |
| 2658 | 4274 | 1424.7 | 106.6 | 35.5 | Functional porous coordination polymers. | Susumu Kitagawa, Ryo Kitaura, Shin-Ichiro Noro | Angew Chem Int Ed Engl | 2004 | 15114565 | Yes |
| 2659 | 2848 | 1424.0 | 78.4 | 39.2 | Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. | D H Figurski, D R Helinski | Proc Natl Acad Sci U S A | 1979 | 377280 | Yes |
| 2660 | 1424 | 1424.0 | 31.5 | 31.5 | Cancer of the ovary. | Stephen A Cannistra | N Engl J Med | 2004 | 15590954 | No |
| 2661 | 1423 | 1423.0 | 35.7 | 35.7 | The prefrontal cortex and cognitive control. | E K Miller | Nat Rev Neurosci | 2000 | 11252769 | No |
| 2662 | 4267 | 1422.3 | 123.5 | 41.2 | Cognitive and emotional influences in anterior cingulate cortex. | G Bush, P Luu, M I Posner | Trends Cogn Sci | 2000 | 10827444 | Yes |
| 2663 | 1422 | 1422.0 | 40.7 | 40.7 | A Wilcoxon-type test for trend. | J Cuzick | Stat Med | 1985 | 3992076 | Yes |
| 2664 | 4266 | 1422.0 | 107.3 | 35.8 | Improved vectors and genome-wide libraries for CRISPR screening. | Neville E Sanjana, Ophir Shalem, Feng Zhang | Nat Methods | 2014 | 25075903 | Yes |
| 2665 | 2843 | 1421.5 | 66.7 | 33.4 | Microenvironmental regulation of metastasis. | Johanna A Joyce, Jeffrey W Pollard | Nat Rev Cancer | 2009 | 19279573 | No |
| 2666 | 1421 | 1421.0 | 77.2 | 77.2 | Psychosocial resilience and protective mechanisms. | Michael Rutter | Am J Orthopsychiatry | 1987 | 3303954 | No |
| 2667 | 2842 | 1421.0 | 65.4 | 32.7 | Disruption of epithelial cell-matrix interactions induces apoptosis. | S M Frisch, H Francis | J Cell Biol | 1994 | 8106557 | Yes |
| 2668 | 1421 | 1421.0 | 34.6 | 34.6 | The basic science of gene therapy. | R C Mulligan | Science | 1993 | 8493530 | No |
| 2669 | 2840 | 1420.0 | 107.6 | 53.8 | Glutathione peroxidase activity in selenium-deficient rat liver. | R A Lawrence, R F Burk | Biochem Biophys Res Commun | 1976 | 971321 | Yes |
| 2670 | 1420 | 1420.0 | 44.1 | 44.1 | The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. | L W Swanson | Brain Res Bull | 1982 | 6816390 | Yes |
| 2671 | 4260 | 1420.0 | 90.0 | 30.0 | Computer visualization of three-dimensional image data using IMOD. | J R Kremer, D N Mastronarde, J R McIntosh | J Struct Biol | 1996 | 8742726 | Yes |
| 2672 | 1419 | 1419.0 | 27.5 | 27.5 | Selection of successive tumour lines for metastasis. | I J Fidler | Nat New Biol | 1973 | 4512654 | Yes |
| 2673 | 1419 | 1419.0 | 32.5 | 32.5 | Long-term potentiation and memory. | M A Lynch | Physiol Rev | 2004 | 14715912 | No |
| 2674 | 1419 | 1419.0 | 71.7 | 71.7 | Systematic text condensation: a strategy for qualitative analysis. | Kirsti Malterud | Scand J Public Health | 2012 | 23221918 | Yes |
| 2675 | 2837 | 1418.5 | 94.2 | 47.1 | A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. | Walter J Paulus, Carsten Tschope | J Am Coll Cardiol | 2013 | 23684677 | No |
| 2676 | 1418 | 1418.0 | 23.5 | 23.5 | A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. | A M Olovnikov | J Theor Biol | 1973 | 4754905 | Yes |
| 2677 | 2835 | 1417.5 | 85.8 | 42.9 | Glycine potentiates the NMDA response in cultured mouse brain neurons. | J W Johnson, P Ascher | Nature | 1987 | 2433595 | Yes |
| 2678 | 1417 | 1417.0 | 23.1 | 23.1 | Cancer. Addiction to oncogenes--the Achilles heal of cancer. | I Bernard Weinstein | Science | 2002 | 12098689 | No |
| 2679 | 1417 | 1417.0 | 49.2 | 49.2 | Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. | Tamas Roszer | Mediators Inflamm | 2015 | 26089604 | No |
| 2680 | 1416 | 1416.0 | 35.6 | 35.6 | Hydrogen sulphide and its therapeutic potential. | Csaba Szabo | Nat Rev Drug Discov | 2007 | 17948022 | No |
| 2681 | 2832 | 1416.0 | 134.4 | 67.2 | An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. | Jesper L R Andersson, Stamatios N Sotiropoulos | Neuroimage | 2016 | 26481672 | Yes |
| 2682 | 1415 | 1415.0 | 58.5 | 58.5 | Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. | R W Bohannon | Age Ageing | 1997 | 9143432 | Yes |
| 2683 | 1415 | 1415.0 | 59.5 | 59.5 | Mediation Analysis: A Practitioner's Guide. | Tyler J VanderWeele | Annu Rev Public Health | 2016 | 26653405 | No |
| 2684 | 1414 | 1414.0 | 50.3 | 50.3 | Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. | M P Blaustein | Am J Physiol | 1977 | 324293 | No |
| 2685 | 1414 | 1414.0 | 33.7 | 33.7 | Surrogate endpoints in clinical trials: definition and operational criteria. | R L Prentice | Stat Med | 1989 | 2727467 | Yes |
| 2686 | 2828 | 1414.0 | 61.8 | 30.9 | Prediction of protein conformation. | P Y Chou, G D Fasman | Biochemistry | 1974 | 4358940 | Yes |
| 2687 | 1414 | 1414.0 | 0.0 | 0.0 | Comparing individual means in the analysis of variance. | J W Tukey | Biometrics | 1949 | 18151955 | Yes |
| 2688 | 2827 | 1413.5 | 72.7 | 36.4 | CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. | D G Higgins, P M Sharp | Gene | 1988 | 3243435 | Yes |
| 2689 | 4240 | 1413.3 | 109.7 | 36.6 | Prediction of total genetic value using genome-wide dense marker maps. | T H Meuwissen, B J Hayes, M E Goddard | Genetics | 2001 | 11290733 | Yes |
| 2690 | 4240 | 1413.3 | 91.4 | 30.5 | Toll-like receptors. | Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira | Annu Rev Immunol | 2003 | 12524386 | No |
| 2691 | 1413 | 1413.0 | 39.5 | 39.5 | Atomic layer deposition: an overview. | Steven M George | Chem Rev | 2010 | 19947596 | Yes |
| 2692 | 1412 | 1412.0 | 33.3 | 33.3 | Protein kinase C: structure, function, and regulation. | A C Newton | J Biol Chem | 1995 | 7499357 | No |
| 2693 | 1412 | 1412.0 | 43.4 | 43.4 | The stress response to trauma and surgery. | J P Desborough | Br J Anaesth | 2000 | 10927999 | No |
| 2694 | 1412 | 1412.0 | 34.2 | 34.2 | Optical microcavities. | Kerry J Vahala | Nature | 2003 | 12917698 | Yes |
| 2695 | 5647 | 1411.8 | 255.6 | 63.9 | Genome sequence-based species delimitation with confidence intervals and improved distance functions. | Jan P Meier-Kolthoff, Alexander F Auch, Hans-Peter Klenk, Markus Goker | BMC Bioinformatics | 2013 | 23432962 | Yes |
| 2696 | 2821 | 1410.5 | 62.9 | 31.4 | Empirical predictions of protein conformation. | P Y Chou, G D Fasman | Annu Rev Biochem | 1978 | 354496 | No |
| 2697 | 7048 | 1409.6 | 204.2 | 40.8 | Transection of the oesophagus for bleeding oesophageal varices. | R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams | Br J Surg | 1973 | 4541913 | Yes |
| 2698 | 2819 | 1409.5 | 125.8 | 62.9 | The role of inflammation in depression: from evolutionary imperative to modern treatment target. | Andrew H Miller, Charles L Raison | Nat Rev Immunol | 2016 | 26711676 | No |
| 2699 | 1409 | 1409.0 | 44.6 | 44.6 | Glutathione metabolism and its selective modification. | A Meister | J Biol Chem | 1988 | 3053703 | No |
| 2700 | 1409 | 1409.0 | 0.0 | 0.0 | Metabolic stability and epigenesis in randomly constructed genetic nets. | S A Kauffman | J Theor Biol | 1969 | 5803332 | Yes |
| 2701 | 1409 | 1409.0 | 40.4 | 40.4 | Psychological and neural mechanisms of the affective dimension of pain. | D D Price | Science | 2000 | 10846154 | No |
| 2702 | 2817 | 1408.5 | 84.3 | 42.1 | Accurate and robust brain image alignment using boundary-based registration. | Douglas N Greve, Bruce Fischl | Neuroimage | 2009 | 19573611 | Yes |
| 2703 | 1408 | 1408.0 | 34.0 | 34.0 | Speculations on the functions of the major heat shock and glucose-regulated proteins. | H R Pelham | Cell | 1986 | 2944601 | Yes |
| 2704 | 1408 | 1408.0 | 44.5 | 44.5 | Circuitry and functional aspects of the insular lobe in primates including humans. | J R Augustine | Brain Res Brain Res Rev | 1996 | 8957561 | No |
| 2705 | 1408 | 1408.0 | 0.0 | 0.0 | The relation of the trail making test to organic brain damage. | R M Reitan | J Consult Psychol | 1955 | 13263471 | Yes |
| 2706 | 2816 | 1408.0 | 74.2 | 37.1 | Biology of incretins: GLP-1 and GIP. | Laurie L Baggio, Daniel J Drucker | Gastroenterology | 2007 | 17498508 | No |
| 2707 | 1407 | 1407.0 | 28.4 | 28.4 | microRNAs: tiny regulators with great potential. | V Ambros | Cell | 2001 | 11779458 | No |
| 2708 | 2814 | 1407.0 | 75.8 | 37.9 | miRBase: integrating microRNA annotation and deep-sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2011 | 21037258 | Yes |
| 2709 | 1406 | 1406.0 | 53.1 | 53.1 | Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases. | K Tamura | Mol Biol Evol | 1992 | 1630306 | Yes |
| 2710 | 1406 | 1406.0 | 39.3 | 39.3 | Infection in solid-organ transplant recipients. | Jay A Fishman | N Engl J Med | 2007 | 18094380 | No |
| 2711 | 1405 | 1405.0 | 30.8 | 30.8 | Codon usage and tRNA content in unicellular and multicellular organisms. | T Ikemura | Mol Biol Evol | 1985 | 3916708 | No |
| 2712 | 1405 | 1405.0 | 41.5 | 41.5 | How brains beware: neural mechanisms of emotional attention. | Patrik Vuilleumier | Trends Cogn Sci | 2005 | 16289871 | Yes |
| 2713 | 1405 | 1405.0 | 34.6 | 34.6 | Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. | G L Semenza | Oncogene | 2010 | 19946328 | No |
| 2714 | 5618 | 1404.5 | 130.2 | 32.5 | Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. | Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun | N Engl J Med | 2003 | 12711737 | Yes |
| 2715 | 1404 | 1404.0 | 50.3 | 50.3 | Mediators and mechanisms of change in psychotherapy research. | Alan E Kazdin | Annu Rev Clin Psychol | 2007 | 17716046 | No |
| 2716 | 1403 | 1403.0 | 42.7 | 42.7 | Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. | E B Hunziker | Osteoarthritis Cartilage | 2002 | 12056848 | No |
| 2717 | 1403 | 1403.0 | 36.0 | 36.0 | Electrochemiluminescence (ECL). | Mark M Richter | Chem Rev | 2004 | 15186186 | No |
| 2718 | 1403 | 1403.0 | 39.0 | 39.0 | Time is brain--quantified. | Jeffrey L Saver | Stroke | 2006 | 16339467 | Yes |
| 2719 | 2805 | 1402.5 | 62.0 | 31.0 | NMR View: A computer program for the visualization and analysis of NMR data. | B A Johnson, R A Blevins | J Biomol NMR | 1994 | 22911360 | Yes |
| 2720 | 1402 | 1402.0 | 48.1 | 48.1 | The biogenesis and emerging roles of circular RNAs. | Ling-Ling Chen | Nat Rev Mol Cell Biol | 2016 | 26908011 | Yes |
| 2721 | 2804 | 1402.0 | 111.0 | 55.5 | Functional Classification and Experimental Dissection of Long Noncoding RNAs. | Florian Kopp, Joshua T Mendell | Cell | 2018 | 29373828 | No |
| 2722 | 4204 | 1401.3 | 98.1 | 32.7 | Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? | Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg | Nat Rev Genet | 2008 | 18197166 | No |
| 2723 | 8407 | 1401.2 | 228.3 | 38.1 | Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. | Ana Conesa, Stefan Gotz, Juan Miguel Garcia-Gomez, Javier Terol, Manuel Talon, Montserrat Robles | Bioinformatics | 2005 | 16081474 | Yes |
| 2724 | 2802 | 1401.0 | 82.6 | 41.3 | Epidemiology and outcomes of osteoporotic fractures. | Steven R Cummings, L Joseph Melton | Lancet | 2002 | 12049882 | No |
| 2725 | 1401 | 1401.0 | 44.4 | 44.4 | Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? | Thomas Grobner | Nephrol Dial Transplant | 2006 | 16431890 | Yes |
| 2726 | 1401 | 1401.0 | 65.0 | 65.0 | The new statistics: why and how. | Geoff Cumming | Psychol Sci | 2014 | 24220629 | Yes |
| 2727 | 14006 | 1400.6 | 524.7 | 52.5 | The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. | Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gotzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David Moher | BMJ | 2009 | 19622552 | No |
| 2728 | 2800 | 1400.0 | 71.8 | 35.9 | A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. | R L Juliano, V Ling | Biochim Biophys Acta | 1976 | 990323 | Yes |
| 2729 | 1400 | 1400.0 | 27.0 | 27.0 | Epithelial-mesenchymal transitions in development and pathologies. | Jean Paul Thiery | Curr Opin Cell Biol | 2003 | 14644200 | No |
| 2730 | 2800 | 1400.0 | 95.7 | 47.9 | Severe sepsis and septic shock. | Derek C Angus, Tom Van Der Poll | N Engl J Med | 2013 | 23984731 | No |
| 2731 | 1400 | 1400.0 | 48.1 | 48.1 | The pathobiology of vascular dementia. | Costantino Iadecola | Neuron | 2013 | 24267647 | No |
| 2732 | 1399 | 1399.0 | 31.3 | 31.3 | Prediction of protein cellular attributes using pseudo-amino acid composition. | K C Chou | Proteins | 2001 | 11288174 | Yes |
| 2733 | 2798 | 1399.0 | 0.0 | 0.0 | Immunoassay of endogenous plasma insulin in man. | R S Yalow, S A Berson | J Clin Invest | 1960 | 13846364 | Yes |
| 2734 | 1399 | 1399.0 | 37.8 | 37.8 | Overview of general physiologic features and functions of vitamin D. | Hector F DeLuca | Am J Clin Nutr | 2004 | 15585789 | No |
| 2735 | 1399 | 1399.0 | 29.6 | 29.6 | Recognition and processing of ubiquitin-protein conjugates by the proteasome. | Daniel Finley | Annu Rev Biochem | 2009 | 19489727 | No |
| 2736 | 2797 | 1398.5 | 63.9 | 31.9 | Raster3D Version 2.0. A program for photorealistic molecular graphics. | E A Merritt, M E Murphy | Acta Crystallogr D Biol Crystallogr | 1994 | 15299354 | Yes |
| 2737 | 1398 | 1398.0 | 31.5 | 31.5 | Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. | M Kozak | Microbiol Rev | 1983 | 6343825 | No |
| 2738 | 2796 | 1398.0 | 178.2 | 89.1 | A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. | E S Grood, W J Suntay | J Biomech Eng | 1983 | 6865355 | Yes |
| 2739 | 2796 | 1398.0 | 58.9 | 29.4 | Regulated portals of entry into the cell. | Sean D Conner, Sandra L Schmid | Nature | 2003 | 12621426 | No |
| 2740 | 5591 | 1397.8 | 188.5 | 47.1 | Validation of a combined comorbidity index. | M Charlson, T P Szatrowski, J Peterson, J Gold | J Clin Epidemiol | 1994 | 7722560 | Yes |
| 2741 | 2795 | 1397.5 | 120.3 | 60.1 | Designing hydrogels for controlled drug delivery. | Jianyu Li, David J Mooney | Nat Rev Mater | 2016 | 29657852 | Yes |
| 2742 | 2793 | 1396.5 | 0.0 | 0.0 | Microdetermination of long-chain fatty acids in plasma and tissues. | V P Dole, H Meinertz | J Biol Chem | 1960 | 13817286 | Yes |
| 2743 | 2793 | 1396.5 | 99.3 | 49.6 | Inflammasomes: mechanism of assembly, regulation and signalling. | Petr Broz, Vishva M Dixit | Nat Rev Immunol | 2016 | 27291964 | No |
| 2744 | 5585 | 1396.2 | 182.0 | 45.5 | Epidemiology and causes of preterm birth. | Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto Romero | Lancet | 2008 | 18177778 | No |
| 2745 | 2792 | 1396.0 | 103.1 | 51.5 | Biology of disease: free radicals and tissue injury. | B A Freeman, J D Crapo | Lab Invest | 1982 | 6290784 | No |
| 2746 | 1396 | 1396.0 | 34.7 | 34.7 | Pathways of oxidative damage. | James A Imlay | Annu Rev Microbiol | 2003 | 14527285 | No |
| 2747 | 2792 | 1396.0 | 83.6 | 41.8 | The cognitive control of emotion. | Kevin N Ochsner, James J Gross | Trends Cogn Sci | 2005 | 15866151 | No |
| 2748 | 8374 | 1395.7 | 254.5 | 42.4 | Free radicals and antioxidants in normal physiological functions and human disease. | Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser | Int J Biochem Cell Biol | 2007 | 16978905 | No |
| 2749 | 2791 | 1395.5 | 74.6 | 37.3 | Epidemiology of Parkinson's disease. | Lonneke M L De Lau, Monique M B Breteler | Lancet Neurol | 2006 | 16713924 | No |
| 2750 | 1395 | 1395.0 | 25.5 | 25.5 | Chromatin modification and epigenetic reprogramming in mammalian development. | En Li | Nat Rev Genet | 2002 | 12209141 | No |
| 2751 | 1395 | 1395.0 | 25.0 | 25.0 | SUMO: a history of modification. | Ronald T Hay | Mol Cell | 2005 | 15808504 | No |
| 2752 | 1395 | 1395.0 | 34.4 | 34.4 | Immortal time bias in pharmaco-epidemiology. | Samy Suissa | Am J Epidemiol | 2008 | 18056625 | No |
| 2753 | 1394 | 1394.0 | 46.6 | 46.6 | Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. | T Spector | Anal Biochem | 1978 | 655375 | Yes |
| 2754 | 2788 | 1394.0 | 124.6 | 62.3 | Activation of apoptosis signalling pathways by reactive oxygen species. | Maureen Redza-Dutordoir, Diana A Averill-Bates | Biochim Biophys Acta | 2016 | 27646922 | No |
| 2755 | 4181 | 1393.7 | 154.6 | 51.5 | A new method for off-line removal of ocular artifact. | G Gratton, M G Coles, E Donchin | Electroencephalogr Clin Neurophysiol | 1983 | 6187540 | Yes |
| 2756 | 2787 | 1393.5 | 103.0 | 51.5 | Communication by Extracellular Vesicles: Where We Are and Where We Need to Go. | Mercedes Tkach, Clotilde Thery | Cell | 2016 | 26967288 | No |
| 2757 | 8356 | 1392.7 | 310.1 | 51.7 | ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB. | James A Maier, Carmenza Martinez, Koushik Kasavajhala, Lauren Wickstrom, Kevin E Hauser, Carlos Simmerling | J Chem Theory Comput | 2015 | 26574453 | Yes |
| 2758 | 1392 | 1392.0 | 30.3 | 30.3 | Mechanisms of foxp3+ T regulatory cell-mediated suppression. | Ethan M Shevach | Immunity | 2009 | 19464986 | No |
| 2759 | 2783 | 1391.5 | 67.8 | 33.9 | Reducing the dimensionality of data with neural networks. | G E Hinton, R R Salakhutdinov | Science | 2006 | 16873662 | Yes |
| 2760 | 1391 | 1391.0 | 46.1 | 46.1 | Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. | A A Grace | Neuroscience | 1991 | 1676137 | No |
| 2761 | 1391 | 1391.0 | 46.8 | 46.8 | Osteoblast adhesion on biomaterials. | K Anselme | Biomaterials | 2000 | 10711964 | No |
| 2762 | 1391 | 1391.0 | 58.4 | 58.4 | The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. | Erik G Willcutt | Neurotherapeutics | 2012 | 22976615 | Yes |
| 2763 | 1390 | 1390.0 | 32.9 | 32.9 | Evaluating medication effects outside of clinical trials: new-user designs. | Wayne A Ray | Am J Epidemiol | 2003 | 14585769 | Yes |
| 2764 | 9727 | 1389.6 | 290.7 | 41.5 | pROC: an open-source package for R and S+ to analyze and compare ROC curves. | Xavier Robin, Natacha Turck, Alexandre Hainard, Natalia Tiberti, Frederique Lisacek, Jean-Charles Sanchez, Markus Muller | BMC Bioinformatics | 2011 | 21414208 | Yes |
| 2765 | 11116 | 1389.5 | 501.4 | 62.7 | Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. | Yingyao Zhou, Bin Zhou, Lars Pache, Max Chang, Alireza Hadj Khodabakhshi, Olga Tanaseichuk, Christopher Benner, Sumit K Chanda | Nat Commun | 2019 | 30944313 | Yes |
| 2766 | 2778 | 1389.0 | 80.9 | 40.5 | Type 2 diabetes as an inflammatory disease. | Marc Y Donath, Steven E Shoelson | Nat Rev Immunol | 2011 | 21233852 | No |
| 2767 | 1389 | 1389.0 | 84.5 | 84.5 | COVID-19 and African Americans. | Clyde W Yancy | JAMA | 2020 | 32293639 | Yes |
| 2768 | 1388 | 1388.0 | 52.1 | 52.1 | The case for motivated reasoning. | Z Kunda | Psychol Bull | 1990 | 2270237 | No |
| 2769 | 2776 | 1388.0 | 85.0 | 42.5 | Mortality by cause for eight regions of the world: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9142060 | Yes |
| 2770 | 1388 | 1388.0 | 0.0 | 0.0 | On the psychophysical law. | S S Stevens | Psychol Rev | 1957 | 13441853 | Yes |
| 2771 | 4162 | 1387.3 | 136.6 | 45.5 | MR diffusion tensor spectroscopy and imaging. | P J Basser, J Mattiello, D LeBihan | Biophys J | 1994 | 8130344 | Yes |
| 2772 | 5546 | 1386.5 | 113.7 | 28.4 | Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. | D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini | Science | 2005 | 15718470 | Yes |
| 2773 | 1386 | 1386.0 | 0.0 | 0.0 | Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. | J R David | Proc Natl Acad Sci U S A | 1966 | 5229858 | Yes |
| 2774 | 1386 | 1386.0 | 39.9 | 39.9 | Polycystic ovary syndrome. | David A Ehrmann | N Engl J Med | 2005 | 15788499 | No |
| 2775 | 5543 | 1385.8 | 236.5 | 59.1 | Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. | L A Papile, J Burstein, R Burstein, H Koffler | J Pediatr | 1978 | 305471 | Yes |
| 2776 | 2771 | 1385.5 | 71.7 | 35.9 | A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. | J Messing, J Vieira | Gene | 1982 | 6295880 | Yes |
| 2777 | 2771 | 1385.5 | 60.2 | 30.1 | Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. | J M Kyriakis, J Avruch | Physiol Rev | 2001 | 11274345 | No |
| 2778 | 2770 | 1385.0 | 57.4 | 28.7 | Community structure in social and biological networks. | M Girvan, M E J Newman | Proc Natl Acad Sci U S A | 2002 | 12060727 | No |
| 2779 | 1385 | 1385.0 | 31.3 | 31.3 | Liver fibrosis -- from bench to bedside. | Scott L Friedman | J Hepatol | 2003 | 12591185 | No |
| 2780 | 1385 | 1385.0 | 0.0 | 0.0 | The anterior approach for removal of ruptured cervical disks. | R B Cloward | J Neurosurg | 1958 | 13599052 | Yes |
| 2781 | 6925 | 1385.0 | 335.4 | 67.1 | Using the framework method for the analysis of qualitative data in multi-disciplinary health research. | Nicola K Gale, Gemma Heath, Elaine Cameron, Sabina Rashid, Sabi Redwood | BMC Med Res Methodol | 2013 | 24047204 | Yes |
| 2782 | 1384 | 1384.0 | 0.0 | 0.0 | Immunological function of the thymus. | J F Miller | Lancet | 1961 | 14474038 | Yes |
| 2783 | 1384 | 1384.0 | 23.7 | 23.7 | Protein modification by SUMO. | Erica S Johnson | Annu Rev Biochem | 2004 | 15189146 | No |
| 2784 | 1384 | 1384.0 | 50.3 | 50.3 | Visual attention: the past 25 years. | Marisa Carrasco | Vision Res | 2011 | 21549742 | No |
| 2785 | 5535 | 1383.8 | 175.7 | 43.9 | Biological identifications through DNA barcodes. | Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R DeWaard | Proc Biol Sci | 2003 | 12614582 | Yes |
| 2786 | 2767 | 1383.5 | 98.6 | 49.3 | A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. | C M Tsai, C E Frasch | Anal Biochem | 1982 | 6176137 | Yes |
| 2787 | 12448 | 1383.1 | 319.4 | 35.5 | MolProbity: all-atom structure validation for macromolecular crystallography. | Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C Richardson | Acta Crystallogr D Biol Crystallogr | 2010 | 20057044 | Yes |
| 2788 | 1383 | 1383.0 | 33.3 | 33.3 | Correlates of protection induced by vaccination. | Stanley A Plotkin | Clin Vaccine Immunol | 2010 | 20463105 | No |
| 2789 | 1382 | 1382.0 | 52.5 | 52.5 | Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. | Thomas Heberer | Toxicol Lett | 2002 | 11988354 | Yes |
| 2790 | 1382 | 1382.0 | 0.0 | 0.0 | Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. | W C Schneider | J Biol Chem | 1948 | 18886166 | Yes |
| 2791 | 1381 | 1381.0 | 42.1 | 42.1 | Internal models for motor control and trajectory planning. | M Kawato | Curr Opin Neurobiol | 1999 | 10607637 | No |
| 2792 | 1381 | 1381.0 | 40.9 | 40.9 | Akaike's information criterion in generalized estimating equations. | W Pan | Biometrics | 2001 | 11252586 | Yes |
| 2793 | 1381 | 1381.0 | 32.7 | 32.7 | The path to ubiquitous and low-cost organic electronic appliances on plastic. | Stephen R Forrest | Nature | 2004 | 15118718 | Yes |
| 2794 | 2761 | 1380.5 | 40.1 | 20.1 | Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. | J E Sulston, H R Horvitz | Dev Biol | 1977 | 838129 | Yes |
| 2795 | 2760 | 1380.0 | 0.0 | 0.0 | A method of trace iodination of proteins for immunologic studies. | P J McConahey, F J Dixon | Int Arch Allergy Appl Immunol | 1966 | 4160044 | Yes |
| 2796 | 2760 | 1380.0 | 62.2 | 31.1 | An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. | A A Beg, D Baltimore | Science | 1996 | 8864118 | Yes |
| 2797 | 1380 | 1380.0 | 38.8 | 38.8 | Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. | Arnold I Caplan | J Cell Physiol | 2007 | 17620285 | No |
| 2798 | 2760 | 1380.0 | 90.4 | 45.2 | Central sensitization: a generator of pain hypersensitivity by central neural plasticity. | Alban Latremoliere, Clifford J Woolf | J Pain | 2009 | 19712899 | No |
| 2799 | 2759 | 1379.5 | 81.6 | 40.8 | Inflammatory mechanisms in obesity. | Margaret F Gregor, Gokhan S Hotamisligil | Annu Rev Immunol | 2011 | 21219177 | No |
| 2800 | 5517 | 1379.2 | 137.7 | 34.4 | The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. | Konstantin Arnold, Lorenza Bordoli, Jurgen Kopp, Torsten Schwede | Bioinformatics | 2006 | 16301204 | Yes |
| 2801 | 2758 | 1379.0 | 72.3 | 36.1 | Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. | D Marion, K Wuthrich | Biochem Biophys Res Commun | 1983 | 6307308 | Yes |
| 2802 | 1378 | 1378.0 | 47.7 | 47.7 | History of the Rochester Epidemiology Project. | L J Melton | Mayo Clin Proc | 1996 | 8594285 | No |
| 2803 | 15148 | 1377.1 | 479.4 | 43.6 | International physical activity questionnaire: 12-country reliability and validity. | Cora L Craig, Alison L Marshall, Michael Sjostrom, Adrian E Bauman, Michael L Booth, Barbara E Ainsworth, Michael Pratt, Ulf Ekelund, Agneta Yngve, James F Sallis, Pekka Oja | Med Sci Sports Exerc | 2003 | 12900694 | Yes |
| 2804 | 1377 | 1377.0 | 40.3 | 40.3 | Letter: Grading of angina pectoris. | L Campeau | Circulation | 1976 | 947585 | Yes |
| 2805 | 1377 | 1377.0 | 34.2 | 34.2 | Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. | G Von Heijne | J Mol Biol | 1992 | 1593632 | Yes |
| 2806 | 2754 | 1377.0 | 73.1 | 36.5 | Hydrogels for tissue engineering. | K Y Lee, D J Mooney | Chem Rev | 2001 | 11710233 | No |
| 2807 | 1377 | 1377.0 | 24.3 | 24.3 | The molecular motor toolbox for intracellular transport. | Ronald D Vale | Cell | 2003 | 12600311 | No |
| 2808 | 2754 | 1377.0 | 104.3 | 52.1 | Tumour heterogeneity and resistance to cancer therapies. | Ibiayi Dagogo-Jack, Alice T Shaw | Nat Rev Clin Oncol | 2018 | 29115304 | No |
| 2809 | 1376 | 1376.0 | 39.5 | 39.5 | Qinghaosu (artemisinin): an antimalarial drug from China. | D L Klayman | Science | 1985 | 3887571 | No |
| 2810 | 2752 | 1376.0 | 83.7 | 41.9 | Crosstalk of reactive oxygen species and NF-κB signaling. | Michael J Morgan, Zheng-Gang Liu | Cell Res | 2011 | 21187859 | No |
| 2811 | 5502 | 1375.5 | 130.4 | 32.6 | Autophagy fights disease through cellular self-digestion. | Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky | Nature | 2008 | 18305538 | No |
| 2812 | 2751 | 1375.5 | 87.1 | 43.5 | The reward circuit: linking primate anatomy and human imaging. | Suzanne N Haber, Brian Knutson | Neuropsychopharmacology | 2010 | 19812543 | No |
| 2813 | 8251 | 1375.2 | 278.5 | 46.4 | The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis. | A Miyake, N P Friedman, M J Emerson, A H Witzki, A Howerter, T D Wager | Cogn Psychol | 2000 | 10945922 | Yes |
| 2814 | 1375 | 1375.0 | 29.3 | 29.3 | The many faces of macrophage activation. | David M Mosser | J Leukoc Biol | 2003 | 12554797 | No |
| 2815 | 1375 | 1375.0 | 28.8 | 28.8 | Searching for intellectual turning points: progressive knowledge domain visualization. | Chaomei Chen | Proc Natl Acad Sci U S A | 2004 | 14724295 | Yes |
| 2816 | 1375 | 1375.0 | 25.8 | 25.8 | Mobile elements: drivers of genome evolution. | Haig H Kazazian | Science | 2004 | 15016989 | No |
| 2817 | 1375 | 1375.0 | 36.4 | 36.4 | Functionalized acenes and heteroacenes for organic electronics. | John E Anthony | Chem Rev | 2006 | 17165682 | Yes |
| 2818 | 1375 | 1375.0 | 42.6 | 42.6 | Tumor delivery of macromolecular drugs based on the EPR effect. | Vladimir Torchilin | Adv Drug Deliv Rev | 2011 | 20304019 | No |
| 2819 | 1375 | 1375.0 | 45.8 | 45.8 | Stochastic thermodynamics, fluctuation theorems and molecular machines. | Udo Seifert | Rep Prog Phys | 2012 | 23168354 | No |
| 2820 | 6874 | 1374.8 | 272.0 | 54.4 | Frailty in elderly people. | Andrew Clegg, John Young, Steve Iliffe, Marcel Olde Rikkert, Kenneth Rockwood | Lancet | 2013 | 23395245 | No |
| 2821 | 4124 | 1374.7 | 122.4 | 40.8 | HMMER web server: interactive sequence similarity searching. | Robert D Finn, Jody Clements, Sean R Eddy | Nucleic Acids Res | 2011 | 21593126 | Yes |
| 2822 | 1374 | 1374.0 | 71.1 | 71.1 | Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. | Anna Maria Carlsson | Pain | 1983 | 6602967 | Yes |
| 2823 | 5493 | 1373.2 | 129.2 | 32.3 | A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. | Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless | Angew Chem Int Ed Engl | 2002 | 12203546 | Yes |
| 2824 | 2746 | 1373.0 | 54.0 | 27.0 | Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. | A J Berk, P A Sharp | Cell | 1977 | 922889 | Yes |
| 2825 | 1373 | 1373.0 | 49.0 | 49.0 | Functional organization of central pathways regulating the cardiovascular system. | R A Dampney | Physiol Rev | 1994 | 8171117 | No |
| 2826 | 1373 | 1373.0 | 36.5 | 36.5 | A molecular view of microbial diversity and the biosphere. | N R Pace | Science | 1997 | 9115194 | No |
| 2827 | 1373 | 1373.0 | 29.8 | 29.8 | Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. | S S Ferguson | Pharmacol Rev | 2001 | 11171937 | No |
| 2828 | 4119 | 1373.0 | 139.9 | 46.6 | Rehospitalizations among patients in the Medicare fee-for-service program. | Stephen F Jencks, Mark V Williams, Eric A Coleman | N Engl J Med | 2009 | 19339721 | Yes |
| 2829 | 2745 | 1372.5 | 0.0 | 0.0 | The respiratory chain and oxidative phosphorylation. | B Chance, G R Williams | Adv Enzymol Relat Subj Biochem | 1956 | 13313307 | Yes |
| 2830 | 4116 | 1372.0 | 92.7 | 30.9 | Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. | J Garnier, D J Osguthorpe, B Robson | J Mol Biol | 1978 | 642007 | Yes |
| 2831 | 4116 | 1372.0 | 180.8 | 60.3 | Measurement of health status. Ascertaining the minimal clinically important difference. | R Jaeschke, J Singer, G H Guyatt | Control Clin Trials | 1989 | 2691207 | Yes |
| 2832 | 1372 | 1372.0 | 0.0 | 0.0 | Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. | W D Hamilton | Science | 1967 | 6021675 | Yes |
| 2833 | 2744 | 1372.0 | 0.0 | 0.0 | A protein sequenator. | P Edman, G Begg | Eur J Biochem | 1967 | 6059350 | Yes |
| 2834 | 1372 | 1372.0 | 33.0 | 33.0 | Targeting DNA topoisomerase II in cancer chemotherapy. | John L Nitiss | Nat Rev Cancer | 2009 | 19377506 | No |
| 2835 | 2743 | 1371.5 | 60.8 | 30.4 | Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. | Jane E Visvader, Geoffrey J Lindeman | Nat Rev Cancer | 2008 | 18784658 | No |
| 2836 | 1371 | 1371.0 | 41.8 | 41.8 | The emotional dog and its rational tail: a social intuitionist approach to moral judgment. | J Haidt | Psychol Rev | 2001 | 11699120 | Yes |
| 2837 | 4113 | 1371.0 | 97.9 | 32.6 | Evolution and functions of long noncoding RNAs. | Chris P Ponting, Peter L Oliver, Wolf Reik | Cell | 2009 | 19239885 | No |
| 2838 | 2741 | 1370.5 | 100.6 | 50.3 | Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. | J M Tanner, R H Whitehouse | Arch Dis Child | 1976 | 952550 | Yes |
| 2839 | 4111 | 1370.3 | 101.3 | 33.8 | METAL: fast and efficient meta-analysis of genomewide association scans. | Cristen J Willer, Yun Li, Goncalo R Abecasis | Bioinformatics | 2010 | 20616382 | Yes |
| 2840 | 2740 | 1370.0 | 66.4 | 33.2 | Principles of bioactive lipid signalling: lessons from sphingolipids. | Yusuf A Hannun, Lina M Obeid | Nat Rev Mol Cell Biol | 2008 | 18216770 | No |
| 2841 | 2739 | 1369.5 | 56.1 | 28.1 | Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. | P J Southern, P Berg | J Mol Appl Genet | 1982 | 6286831 | Yes |
| 2842 | 1369 | 1369.0 | 44.7 | 44.7 | Cognitive and affective development in adolescence. | Laurence Steinberg | Trends Cogn Sci | 2005 | 15668099 | No |
| 2843 | 1369 | 1369.0 | 38.9 | 38.9 | Water as an active constituent in cell biology. | Philip Ball | Chem Rev | 2008 | 18095715 | No |
| 2844 | 2737 | 1368.5 | 66.2 | 33.1 | Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. | P Van Den Driessche, James Watmough | Math Biosci | 2002 | 12387915 | Yes |
| 2845 | 2737 | 1368.5 | 77.5 | 38.8 | Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis). | S M Rogers, L Bernatchez | Mol Ecol | 2005 | 15660930 | Yes |
| 2846 | 2736 | 1368.0 | 144.2 | 72.1 | A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. | M Roland, R Morris | Spine (Phila Pa 1976) | 1983 | 6222486 | Yes |
| 2847 | 1368 | 1368.0 | 52.7 | 52.7 | Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. | M A Lemp | CLAO J | 1995 | 8565190 | No |
| 2848 | 1368 | 1368.0 | 47.7 | 47.7 | An application of prefrontal cortex function theory to cognitive aging. | R L West | Psychol Bull | 1996 | 8831298 | No |
| 2849 | 4104 | 1368.0 | 103.5 | 34.5 | Astrocyte-endothelial interactions at the blood-brain barrier. | N Joan Abbott, Lars Ronnback, Elisabeth Hansson | Nat Rev Neurosci | 2006 | 16371949 | No |
| 2850 | 10943 | 1367.9 | 282.4 | 35.3 | A method and server for predicting damaging missense mutations. | Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev | Nat Methods | 2010 | 20354512 | Yes |
| 2851 | 5471 | 1367.8 | 297.9 | 74.5 | Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks. | Shaoqing Ren, Kaiming He, Ross Girshick, Jian Sun | IEEE Trans Pattern Anal Mach Intell | 2017 | 27295650 | Yes |
| 2852 | 2735 | 1367.5 | 183.5 | 91.8 | Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. | R B Gustilo, J T Anderson | J Bone Joint Surg Am | 1976 | 773941 | Yes |
| 2853 | 2735 | 1367.5 | 50.2 | 25.1 | Rab proteins as membrane organizers. | M Zerial, H McBride | Nat Rev Mol Cell Biol | 2001 | 11252952 | No |
| 2854 | 1367 | 1367.0 | 43.3 | 43.3 | The inflammatory response in myocardial injury, repair, and remodelling. | Nikolaos G Frangogiannis | Nat Rev Cardiol | 2014 | 24663091 | No |
| 2855 | 1366 | 1366.0 | 48.2 | 48.2 | Interleukin-1. | C A Dinarello | Rev Infect Dis | 1984 | 6369481 | No |
| 2856 | 1366 | 1366.0 | 0.0 | 0.0 | An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. | O Smithies | Biochem J | 1959 | 13638269 | Yes |
| 2857 | 1366 | 1366.0 | 174.3 | 174.3 | Ultrafast one-pass FASTQ data preprocessing, quality control, and deduplication using fastp. | Shifu Chen | Imeta | 2023 | 38868435 | Yes |
| 2858 | 2731 | 1365.5 | 77.8 | 38.9 | A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. | Yan Zhao, Donald G Truhlar | J Chem Phys | 2006 | 17129083 | Yes |
| 2859 | 4096 | 1365.3 | 105.0 | 35.0 | Atomic force microscope. | G Binnig, C F Quate, C Gerber | Phys Rev Lett | 1986 | 10033323 | Yes |
| 2860 | 8192 | 1365.3 | 343.8 | 57.3 | Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. | Zobair M Younossi, Aaron B Koenig, Dinan Abdelatif, Yousef Fazel, Linda Henry, Mark Wymer | Hepatology | 2016 | 26707365 | No |
| 2861 | 1365 | 1365.0 | 38.6 | 38.6 | Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. | R M Sapolsky | Arch Gen Psychiatry | 2000 | 11015810 | No |
| 2862 | 1365 | 1365.0 | 38.8 | 38.8 | The locus coeruleus and noradrenergic modulation of cognition. | Susan J Sara | Nat Rev Neurosci | 2009 | 19190638 | No |
| 2863 | 5458 | 1364.5 | 146.8 | 36.7 | Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. | Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan | Stat Med | 2008 | 17569110 | Yes |
| 2864 | 1364 | 1364.0 | 51.7 | 51.7 | The life and times of the Enterococcus. | B E Murray | Clin Microbiol Rev | 1990 | 2404568 | No |
| 2865 | 1364 | 1364.0 | 48.7 | 48.7 | Multiple calcium channels and neuronal function. | R J Miller | Science | 1987 | 2432656 | No |
| 2866 | 1364 | 1364.0 | 54.4 | 54.4 | Geriatric Depression Scale. | J A Yesavage | Psychopharmacol Bull | 1988 | 3249773 | Yes |
| 2867 | 1364 | 1364.0 | 62.8 | 62.8 | Review of the psychometric evidence of the perceived stress scale. | Eun-Hyun Lee | Asian Nurs Res (Korean Soc Nurs Sci) | 2012 | 25031113 | Yes |
| 2868 | 1363 | 1363.0 | 43.1 | 43.1 | Neurotransmitters and neuromodulators in the basal ganglia. | A M Graybiel | Trends Neurosci | 1990 | 1695398 | No |
| 2869 | 1363 | 1363.0 | 43.1 | 43.1 | The phenomenon of the acute phase response. | I Kushner | Ann N Y Acad Sci | 1982 | 7046585 | No |
| 2870 | 2726 | 1363.0 | 92.7 | 46.4 | Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. | Hirenkumar K Makadia, Steven J Siegel | Polymers (Basel) | 2011 | 22577513 | Yes |
| 2871 | 4088 | 1362.7 | 216.4 | 72.1 | Assessing coping strategies: a theoretically based approach. | C S Carver, M F Scheier, J K Weintraub | J Pers Soc Psychol | 1989 | 2926629 | Yes |
| 2872 | 5450 | 1362.5 | 129.9 | 32.5 | Quantitative monitoring of gene expression patterns with a complementary DNA microarray. | M Schena, D Shalon, R W Davis, P O Brown | Science | 1995 | 7569999 | Yes |
| 2873 | 2724 | 1362.0 | 70.6 | 35.3 | A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. | B G Durie, S E Salmon | Cancer | 1975 | 1182674 | Yes |
| 2874 | 1362 | 1362.0 | 31.0 | 31.0 | Assortative mixing in networks. | M E J Newman | Phys Rev Lett | 2002 | 12443515 | Yes |
| 2875 | 1362 | 1362.0 | 29.5 | 29.5 | Hypoxia, HIF1 and glucose metabolism in the solid tumour. | Nicholas C Denko | Nat Rev Cancer | 2008 | 19143055 | No |
| 2876 | 2723 | 1361.5 | 57.5 | 28.8 | TM-align: a protein structure alignment algorithm based on the TM-score. | Yang Zhang, Jeffrey Skolnick | Nucleic Acids Res | 2005 | 15849316 | Yes |
| 2877 | 1361 | 1361.0 | 41.2 | 41.2 | Renin-angiotensin system: biochemistry and mechanisms of action. | M J Peach | Physiol Rev | 1977 | 191856 | No |
| 2878 | 1361 | 1361.0 | 0.0 | 0.0 | Blood gas calculator. | J W Severinghaus | J Appl Physiol | 1966 | 5912737 | Yes |
| 2879 | 2722 | 1361.0 | 78.3 | 39.1 | Mitochondria: in sickness and in health. | Jodi Nunnari, Anu Suomalainen | Cell | 2012 | 22424226 | No |
| 2880 | 2722 | 1361.0 | 121.2 | 60.6 | Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. | Luigi Ferrucci, Elisa Fabbri | Nat Rev Cardiol | 2018 | 30065258 | No |
| 2881 | 2721 | 1360.5 | 74.4 | 37.2 | Hydrogels for tissue engineering: scaffold design variables and applications. | Jeanie L Drury, David J Mooney | Biomaterials | 2003 | 12922147 | No |
| 2882 | 1360 | 1360.0 | 29.1 | 29.1 | The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. | G B Morin | Cell | 1989 | 2805070 | Yes |
| 2883 | 1360 | 1360.0 | 36.5 | 36.5 | Automatic quantitation of localized in vivo 1H spectra with LCModel. | S W Provencher | NMR Biomed | 2001 | 11410943 | Yes |
| 2884 | 1360 | 1360.0 | 45.1 | 45.1 | Drug transport across the blood-brain barrier. | William M Pardridge | J Cereb Blood Flow Metab | 2012 | 22929442 | No |
| 2885 | 2720 | 1360.0 | 146.6 | 73.3 | Making Neighborhood-Disadvantage Metrics Accessible - The Neighborhood Atlas. | Amy J H Kind, William R Buckingham | N Engl J Med | 2018 | 29949490 | Yes |
| 2886 | 2719 | 1359.5 | 57.9 | 28.9 | Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. | M Zuker, P Stiegler | Nucleic Acids Res | 1981 | 6163133 | Yes |
| 2887 | 2719 | 1359.5 | 81.7 | 40.9 | What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? | K C Berridge, T E Robinson | Brain Res Brain Res Rev | 1998 | 9858756 | No |
| 2888 | 1359 | 1359.0 | 61.4 | 61.4 | A cochlear frequency-position function for several species--29 years later. | D D Greenwood | J Acoust Soc Am | 1990 | 2373794 | Yes |
| 2889 | 1359 | 1359.0 | 47.2 | 47.2 | The theoretical bases of indirect calorimetry: a review. | E Ferrannini | Metabolism | 1988 | 3278194 | No |
| 2890 | 1358 | 1358.0 | 35.5 | 35.5 | Thioredoxin and glutaredoxin systems. | A Holmgren | J Biol Chem | 1989 | 2668278 | No |
| 2891 | 1358 | 1358.0 | 0.0 | 0.0 | Disconnexion syndromes in animals and man. I. | N Geschwind | Brain | 1965 | 5318481 | No |
| 2892 | 1358 | 1358.0 | 27.6 | 27.6 | Dimerization of cell surface receptors in signal transduction. | C H Heldin | Cell | 1995 | 7834741 | No |
| 2893 | 1358 | 1358.0 | 26.3 | 26.3 | Chromosomal translocations in human cancer. | T H Rabbitts | Nature | 1994 | 7969446 | No |
| 2894 | 2716 | 1358.0 | 78.2 | 39.1 | Humans integrate visual and haptic information in a statistically optimal fashion. | Marc O Ernst, Martin S Banks | Nature | 2002 | 11807554 | Yes |
| 2895 | 1358 | 1358.0 | 0.0 | 0.0 | Effects of varying the vehicle for OsO4 in tissue fixation. | J B Caulfield | J Biophys Biochem Cytol | 1957 | 13475399 | Yes |
| 2896 | 1357 | 1357.0 | 42.7 | 42.7 | Determining association constants from titration experiments in supramolecular chemistry. | Pall Thordarson | Chem Soc Rev | 2011 | 21125111 | Yes |
| 2897 | 4070 | 1356.7 | 146.2 | 48.7 | Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. | B K Matuszewski, M L Constanzer, C M Chavez-Eng | Anal Chem | 2003 | 12964746 | Yes |
| 2898 | 2712 | 1356.0 | 59.0 | 29.5 | Liver regeneration. | G K Michalopoulos, M C DeFrances | Science | 1997 | 9082986 | No |
| 2899 | 2711 | 1355.5 | 72.4 | 36.2 | Apoptosis, oncosis, and necrosis. An overview of cell death. | G Majno, I Joris | Am J Pathol | 1995 | 7856735 | No |
| 2900 | 2711 | 1355.5 | 64.5 | 32.2 | A comparison of bayesian methods for haplotype reconstruction from population genotype data. | Matthew Stephens, Peter Donnelly | Am J Hum Genet | 2003 | 14574645 | Yes |
| 2901 | 1355 | 1355.0 | 59.5 | 59.5 | Molecular pathology of schizophrenia: more than one disease process? | T J Crow | Br Med J | 1980 | 6101544 | No |
| 2902 | 2710 | 1355.0 | 62.5 | 31.2 | Cellular processing of platinum anticancer drugs. | Dong Wang, Stephen J Lippard | Nat Rev Drug Discov | 2005 | 15789122 | No |
| 2903 | 1355 | 1355.0 | 27.6 | 27.6 | Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. | Sean B Carroll | Cell | 2008 | 18614008 | Yes |
| 2904 | 1355 | 1355.0 | 37.5 | 37.5 | N-heterocyclic carbenes: a new concept in organometallic catalysis. | Wolfgang A Herrmann | Angew Chem Int Ed Engl | 2002 | 19750753 | Yes |
| 2905 | 4063 | 1354.3 | 0.0 | 0.0 | Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. | D D Sabatini, K Bensch, R J Barrnett | J Cell Biol | 1963 | 13975866 | Yes |
| 2906 | 1354 | 1354.0 | 37.2 | 37.2 | Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. | S L Friedman | N Engl J Med | 1993 | 8502273 | No |
| 2907 | 2708 | 1354.0 | 63.7 | 31.9 | The RXR heterodimers and orphan receptors. | D J Mangelsdorf, R M Evans | Cell | 1995 | 8521508 | No |
| 2908 | 1354 | 1354.0 | 40.5 | 40.5 | The effects of stressful life events on depression. | R C Kessler | Annu Rev Psychol | 1997 | 9046559 | No |
| 2909 | 1353 | 1353.0 | 45.7 | 45.7 | Carnitine--metabolism and functions. | J Bremer | Physiol Rev | 1983 | 6361812 | No |
| 2910 | 1353 | 1353.0 | 29.5 | 29.5 | The advantages and disadvantages of being polyploid. | Luca Comai | Nat Rev Genet | 2005 | 16304599 | No |
| 2911 | 1353 | 1353.0 | 33.3 | 33.3 | Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. | R Balfour Sartor | Nat Clin Pract Gastroenterol Hepatol | 2006 | 16819502 | No |
| 2912 | 1353 | 1353.0 | 39.6 | 39.6 | Electrochemical glucose biosensors. | Joseph Wang | Chem Rev | 2008 | 18154363 | No |
| 2913 | 2703 | 1351.5 | 80.8 | 40.4 | Ischemia and reperfusion--from mechanism to translation. | Holger K Eltzschig, Tobias Eckle | Nat Med | 2011 | 22064429 | No |
| 2914 | 4054 | 1351.3 | 100.0 | 33.3 | Dystrophin: the protein product of the Duchenne muscular dystrophy locus. | E P Hoffman, R H Brown, L M Kunkel | Cell | 1987 | 3319190 | Yes |
| 2915 | 2702 | 1351.0 | 69.2 | 34.6 | Drug delivery systems: entering the mainstream. | Theresa M Allen, Pieter R Cullis | Science | 2004 | 15031496 | Yes |
| 2916 | 1351 | 1351.0 | 143.9 | 143.9 | Sample size determination and power analysis using the G*Power software. | Hyun Kang | J Educ Eval Health Prof | 2021 | 34325496 | No |
| 2917 | 2701 | 1350.5 | 0.0 | 0.0 | A Generalization Of The Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography. | H Vandendool, P D Kratz | J Chromatogr | 1963 | 14062605 | Yes |
| 2918 | 1350 | 1350.0 | 0.0 | 0.0 | Intra-sexual selection in Drosophila. | A J Bateman | Heredity (Edinb) | 1948 | 18103134 | Yes |
| 2919 | 2699 | 1349.5 | 74.1 | 37.0 | Neuronal plasticity: increasing the gain in pain. | C J Woolf, M W Salter | Science | 2000 | 10846153 | No |
| 2920 | 1349 | 1349.0 | 0.0 | 0.0 | A simple ultraviolet spectrophotometric method for the determination of protein. | W J Waddell | J Lab Clin Med | 1956 | 13346201 | Yes |
| 2921 | 6743 | 1348.6 | 196.3 | 39.3 | Quantitative assessment of tactile allodynia in the rat paw. | S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L Yaksh | J Neurosci Methods | 1994 | 7990513 | Yes |
| 2922 | 2697 | 1348.5 | 58.3 | 29.1 | Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. | G Blobel, B Dobberstein | J Cell Biol | 1975 | 811671 | Yes |
| 2923 | 1348 | 1348.0 | 31.9 | 31.9 | Transcriptional paradigms in mammalian mitochondrial biogenesis and function. | Richard C Scarpulla | Physiol Rev | 2008 | 18391175 | No |
| 2924 | 1347 | 1347.0 | 55.9 | 55.9 | Bone "mass" and the "mechanostat": a proposal. | H M Frost | Anat Rec | 1987 | 3688455 | Yes |
| 2925 | 4041 | 1347.0 | 108.4 | 36.1 | Use and abuse of HOMA modeling. | Tara M Wallace, Jonathan C Levy, David R Matthews | Diabetes Care | 2004 | 15161807 | No |
| 2926 | 5388 | 1347.0 | 150.1 | 37.5 | Measurement of the elastic properties and intrinsic strength of monolayer graphene. | Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James Hone | Science | 2008 | 18635798 | Yes |
| 2927 | 2693 | 1346.5 | 0.0 | 0.0 | Functions of lysosomes. | C De Duve, R Wattiaux | Annu Rev Physiol | 1966 | 5322983 | No |
| 2928 | 2693 | 1346.5 | 62.4 | 31.2 | Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. | Kornelia Polyak, Robert A Weinberg | Nat Rev Cancer | 2009 | 19262571 | No |
| 2929 | 4039 | 1346.3 | 148.6 | 49.5 | The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting. | C Kirschbaum, K M Pirke, D H Hellhammer | Neuropsychobiology | 1993 | 8255414 | Yes |
| 2930 | 1346 | 1346.0 | 40.1 | 40.1 | Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. | S G Johnsen | Hormones | 1970 | 5527187 | Yes |
| 2931 | 2692 | 1346.0 | 54.9 | 27.4 | Proliferation, cell cycle and apoptosis in cancer. | G I Evan, K H Vousden | Nature | 2001 | 11357141 | No |
| 2932 | 1346 | 1346.0 | 35.3 | 35.3 | Plasmonics: merging photonics and electronics at nanoscale dimensions. | Ekmel Ozbay | Science | 2006 | 16410515 | Yes |
| 2933 | 2691 | 1345.5 | 86.1 | 43.0 | Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. | G J Miller, N E Miller | Lancet | 1975 | 46338 | Yes |
| 2934 | 2691 | 1345.5 | 56.1 | 28.1 | Tumorigenesis and the angiogenic switch. | Gabriele Bergers, Laura E Benjamin | Nat Rev Cancer | 2003 | 12778130 | No |
| 2935 | 1345 | 1345.0 | 58.8 | 58.8 | Biomaterial-centered infection: microbial adhesion versus tissue integration. | A G Gristina | Science | 1987 | 3629258 | Yes |
| 2936 | 1345 | 1345.0 | 0.0 | 0.0 | The nature and significance of platelet products in human plasma. | P Wolf | Br J Haematol | 1967 | 6025241 | Yes |
| 2937 | 1345 | 1345.0 | 32.2 | 32.2 | Neurobiology of Pavlovian fear conditioning. | S Maren | Annu Rev Neurosci | 2001 | 11520922 | No |
| 2938 | 2688 | 1344.0 | 64.1 | 32.0 | NF-kappa B: ten years after. | P A Baeuerle, D Baltimore | Cell | 1996 | 8858144 | No |
| 2939 | 1344 | 1344.0 | 36.4 | 36.4 | Optimal experimental design for event-related fMRI. | A M Dale | Hum Brain Mapp | 1999 | 10524601 | Yes |
| 2940 | 1344 | 1344.0 | 38.4 | 38.4 | Plant productivity and environment. | J S Boyer | Science | 1982 | 17808529 | Yes |
| 2941 | 1344 | 1344.0 | 44.0 | 44.0 | A practical solution to the pervasive problems of p values. | Eric-Jan Wagenmakers | Psychon Bull Rev | 2007 | 18087943 | Yes |
| 2942 | 2688 | 1344.0 | 113.2 | 56.6 | Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. | Ian Janssen, Allana G Leblanc | Int J Behav Nutr Phys Act | 2010 | 20459784 | Yes |
| 2943 | 2688 | 1344.0 | 108.0 | 54.0 | Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. | Michael A Gimbrone, Guillermo Garcia-Cardena | Circ Res | 2016 | 26892962 | No |
| 2944 | 2687 | 1343.5 | 75.6 | 37.8 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. | Ajay Kumar Gupta, Mona Gupta | Biomaterials | 2005 | 15626447 | No |
| 2945 | 1343 | 1343.0 | 33.5 | 33.5 | Oxyradicals and DNA damage. | L J Marnett | Carcinogenesis | 2000 | 10688856 | No |
| 2946 | 2686 | 1343.0 | 76.9 | 38.5 | Meeting of minds: the medial frontal cortex and social cognition. | David M Amodio, Chris D Frith | Nat Rev Neurosci | 2006 | 16552413 | No |
| 2947 | 4028 | 1342.7 | 106.8 | 35.6 | Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? | Dunyaporn Trachootham, Jerome Alexandre, Peng Huang | Nat Rev Drug Discov | 2009 | 19478820 | No |
| 2948 | 2685 | 1342.5 | 60.1 | 30.1 | The pathophysiology of mitochondrial cell death. | Douglas R Green, Guido Kroemer | Science | 2004 | 15286356 | No |
| 2949 | 1342 | 1342.0 | 36.3 | 36.3 | Fibronectin and its receptors. | E Ruoslahti | Annu Rev Biochem | 1988 | 2972252 | No |
| 2950 | 1342 | 1342.0 | 47.5 | 47.5 | Neuropeptide Y: complete amino acid sequence of the brain peptide. | K Tatemoto | Proc Natl Acad Sci U S A | 1982 | 6957876 | Yes |
| 2951 | 1342 | 1342.0 | 62.1 | 62.1 | Error in medicine. | L L Leape | JAMA | 1994 | 7503827 | Yes |
| 2952 | 2684 | 1342.0 | 111.5 | 55.8 | The Posttraumatic Growth Inventory: measuring the positive legacy of trauma. | R G Tedeschi, L G Calhoun | J Trauma Stress | 1996 | 8827649 | Yes |
| 2953 | 1342 | 1342.0 | 0.0 | 0.0 | A simple objective technique for measuring flexibility in thinking. | E A Berg | J Gen Psychol | 1948 | 18889466 | Yes |
| 2954 | 1341 | 1341.0 | 36.3 | 36.3 | The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. | K Kuwajima | Proteins | 1989 | 2695928 | No |
| 2955 | 1341 | 1341.0 | 29.2 | 29.2 | The stem-cell niche as an entity of action. | David T Scadden | Nature | 2006 | 16810242 | No |
| 2956 | 1341 | 1341.0 | 50.7 | 50.7 | Epidemiology and risk factors for IBD. | Ashwin N Ananthakrishnan | Nat Rev Gastroenterol Hepatol | 2015 | 25732745 | No |
| 2957 | 2681 | 1340.5 | 76.3 | 38.1 | Ageing and Parkinson's disease: substantia nigra regional selectivity. | J M Fearnley, A J Lees | Brain | 1991 | 1933245 | Yes |
| 2958 | 2681 | 1340.5 | 0.0 | 0.0 | Surgical risk as related to time of intervention in the repair of intracranial aneurysms. | W E Hunt, R M Hess | J Neurosurg | 1968 | 5635959 | Yes |
| 2959 | 2681 | 1340.5 | 394.3 | 197.2 | Sample sizes for saturation in qualitative research: A systematic review of empirical tests. | Monique Hennink, Bonnie N Kaiser | Soc Sci Med | 2022 | 34785096 | Yes |
| 2960 | 4021 | 1340.3 | 144.9 | 48.3 | Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. | Dmitry B Zorov, Magdalena Juhaszova, Steven J Sollott | Physiol Rev | 2014 | 24987008 | No |
| 2961 | 1340 | 1340.0 | 23.0 | 23.0 | Cancer susceptibility and the functions of BRCA1 and BRCA2. | Ashok R Venkitaraman | Cell | 2002 | 11832208 | No |
| 2962 | 1340 | 1340.0 | 43.9 | 43.9 | Delirium in older persons. | Sharon K Inouye | N Engl J Med | 2006 | 16540616 | No |
| 2963 | 1339 | 1339.0 | 35.6 | 35.6 | Supported membranes: scientific and practical applications. | E Sackmann | Science | 1996 | 8539599 | No |
| 2964 | 1339 | 1339.0 | 31.2 | 31.2 | Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. | William C Aird | Circ Res | 2007 | 17272818 | No |
| 2965 | 2677 | 1338.5 | 60.7 | 30.4 | Prediction of the secondary structure of proteins from their amino acid sequence. | P Y Chou, G D Fasman | Adv Enzymol Relat Areas Mol Biol | 1978 | 364941 | No |
| 2966 | 2677 | 1338.5 | 50.2 | 25.1 | New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. | R D Gietz, A Sugino | Gene | 1988 | 3073106 | Yes |
| 2967 | 1338 | 1338.0 | 0.0 | 0.0 | Stereological principles for morphometry in electron microscopic cytology. | E R Weibel | Int Rev Cytol | 1969 | 4899604 | No |
| 2968 | 1338 | 1338.0 | 40.9 | 40.9 | The biochemistry and medical significance of the flavonoids. | Bent H Havsteen | Pharmacol Ther | 2002 | 12453566 | No |
| 2969 | 1338 | 1338.0 | 0.0 | 0.0 | A modified procedure for lead staining of thin sections. | G Millonig | J Biophys Biochem Cytol | 1961 | 14474176 | Yes |
| 2970 | 1338 | 1338.0 | 48.0 | 48.0 | Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. | L Sjostrom | J Intern Med | 2013 | 23163728 | No |
| 2971 | 1337 | 1337.0 | 30.2 | 30.2 | Human papillomavirus and cervical cancer. | Eileen M Burd | Clin Microbiol Rev | 2003 | 12525422 | No |
| 2972 | 2674 | 1337.0 | 74.4 | 37.2 | Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. | Barry J Everitt, Trevor W Robbins | Nat Neurosci | 2005 | 16251991 | No |
| 2973 | 4008 | 1336.0 | 117.2 | 39.1 | Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. | Gunter Oberdorster, Eva Oberdorster, Jan Oberdorster | Environ Health Perspect | 2005 | 16002369 | No |
| 2974 | 2672 | 1336.0 | 73.0 | 36.5 | BODIPY dyes and their derivatives: syntheses and spectroscopic properties. | Aurore Loudet, Kevin Burgess | Chem Rev | 2007 | 17924696 | Yes |
| 2975 | 4007 | 1335.7 | 121.4 | 40.5 | The functional anatomy of basal ganglia disorders. | R L Albin, A B Young, J B Penney | Trends Neurosci | 1989 | 2479133 | No |
| 2976 | 4007 | 1335.7 | 128.8 | 42.9 | Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. | Geoffrey R Norman, Jeff A Sloan, Kathleen W Wyrwich | Med Care | 2003 | 12719681 | Yes |
| 2977 | 2671 | 1335.5 | 76.3 | 38.1 | Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. | E Engvall, P Perlmann | J Immunol | 1972 | 4113792 | Yes |
| 2978 | 2671 | 1335.5 | 0.0 | 0.0 | Further improvements in the plaque technique for detecting single antibody-forming cells. | A J Cunningham, A Szenberg | Immunology | 1968 | 5653817 | Yes |
| 2979 | 2671 | 1335.5 | 48.3 | 24.1 | DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. | Christopher J Bakkenist, Michael B Kastan | Nature | 2003 | 12556884 | Yes |
| 2980 | 1335 | 1335.0 | 52.5 | 52.5 | Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. | K Satoh | Clin Chim Acta | 1978 | 719890 | Yes |
| 2981 | 1335 | 1335.0 | 30.9 | 30.9 | Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. | W D Snider | Cell | 1994 | 8205613 | No |
| 2982 | 2670 | 1335.0 | 62.3 | 31.1 | Establishing, maintaining and modifying DNA methylation patterns in plants and animals. | Julie A Law, Steven E Jacobsen | Nat Rev Genet | 2010 | 20142834 | No |
| 2983 | 1335 | 1335.0 | 0.0 | 0.0 | Limitations of the application of fourfold table analysis to hospital data. | J Berkson | Biometrics | 1946 | 21001024 | Yes |
| 2984 | 1335 | 1335.0 | 32.5 | 32.5 | Molecular genetics of colorectal cancer. | Eric R Fearon | Annu Rev Pathol | 2011 | 21090969 | No |
| 2985 | 2669 | 1334.5 | 101.4 | 50.7 | Reading senseless sentences: brain potentials reflect semantic incongruity. | M Kutas, S A Hillyard | Science | 1980 | 7350657 | Yes |
| 2986 | 1334 | 1334.0 | 28.4 | 28.4 | Fibrotic disease and the T(H)1/T(H)2 paradigm. | Thomas A Wynn | Nat Rev Immunol | 2004 | 15286725 | No |
| 2987 | 1334 | 1334.0 | 40.6 | 40.6 | Depression in the elderly. | George S Alexopoulos | Lancet | 2005 | 15936426 | No |
| 2988 | 1334 | 1334.0 | 40.0 | 40.0 | Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. | Antoine Bechara | Nat Neurosci | 2005 | 16251988 | No |
| 2989 | 5333 | 1333.2 | 135.4 | 33.9 | Improved prediction of signal peptides: SignalP 3.0. | Jannick Dyrlov Bendtsen, Henrik Nielsen, Gunnar Von Heijne, Soren Brunak | J Mol Biol | 2004 | 15223320 | Yes |
| 2990 | 2666 | 1333.0 | 83.7 | 41.9 | Multiple significance tests: the Bonferroni method. | J M Bland, D G Altman | BMJ | 1995 | 7833759 | Yes |
| 2991 | 2666 | 1333.0 | 93.8 | 46.9 | Self-management education: history, definition, outcomes, and mechanisms. | Kate R Lorig, Halsted Holman | Ann Behav Med | 2003 | 12867348 | No |
| 2992 | 1333 | 1333.0 | 56.3 | 56.3 | Cystic fibrosis. | J Stuart Elborn | Lancet | 2016 | 27140670 | No |
| 2993 | 2665 | 1332.5 | 82.9 | 41.5 | A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. | A Ennaceur, J Delacour | Behav Brain Res | 1988 | 3228475 | Yes |
| 2994 | 2665 | 1332.5 | 86.4 | 43.2 | The complexity of NF-κB signaling in inflammation and cancer. | Bastian Hoesel, Johannes A Schmid | Mol Cancer | 2013 | 23915189 | No |
| 2995 | 1332 | 1332.0 | 0.0 | 0.0 | On the local reactions of the arterial wall to changes of internal pressure. | W M Bayliss | J Physiol | 1902 | 16992618 | Yes |
| 2996 | 2663 | 1331.5 | 91.2 | 45.6 | Oxidative mechanisms in the toxicity of metal ions. | S J Stohs, D Bagchi | Free Radic Biol Med | 1995 | 7744317 | No |
| 2997 | 2663 | 1331.5 | 71.1 | 35.5 | Mechanisms of mitophagy. | Richard J Youle, Derek P Narendra | Nat Rev Mol Cell Biol | 2011 | 21179058 | No |
| 2998 | 1331 | 1331.0 | 0.0 | 0.0 | Cellular resistance to infection. | G B MacKaness | J Exp Med | 1962 | 14467923 | Yes |
| 2999 | 3993 | 1331.0 | 161.5 | 53.8 | Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. | Antonio Ayala, Mario F Munoz, Sandro Arguelles | Oxid Med Cell Longev | 2014 | 24999379 | No |
| 3000 | 6653 | 1330.6 | 336.7 | 67.3 | Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. | N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W Stitt | J Rheumatol | 1988 | 3068365 | Yes |
| 3001 | 5322 | 1330.5 | 129.3 | 32.3 | Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. | D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli | J Biol Chem | 1977 | 320200 | Yes |
| 3002 | 1330 | 1330.0 | 33.3 | 33.3 | The mitochondrial electron transport and oxidative phosphorylation system. | Y Hatefi | Annu Rev Biochem | 1985 | 2862839 | No |
| 3003 | 1330 | 1330.0 | 52.6 | 52.6 | Free-radical mechanisms in tissue injury. | T F Slater | Biochem J | 1984 | 6383353 | No |
| 3004 | 3989 | 1329.7 | 149.3 | 49.8 | Qualitative research in health care. Analysing qualitative data. | C Pope, S Ziebland, N Mays | BMJ | 2000 | 10625273 | No |
| 3005 | 2659 | 1329.5 | 68.6 | 34.3 | Interneurons of the hippocampus. | T F Freund, G Buzsaki | Hippocampus | 1996 | 8915675 | No |
| 3006 | 2659 | 1329.5 | 58.8 | 29.4 | Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. | Eugenia E Calle, Rudolf Kaaks | Nat Rev Cancer | 2004 | 15286738 | No |
| 3007 | 2659 | 1329.5 | 65.1 | 32.5 | ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. | Benoit D'Autreaux, Michel B Toledano | Nat Rev Mol Cell Biol | 2007 | 17848967 | No |
| 3008 | 1329 | 1329.0 | 35.3 | 35.3 | Plant salt tolerance. | J K Zhu | Trends Plant Sci | 2001 | 11173290 | Yes |
| 3009 | 2658 | 1329.0 | 62.5 | 31.2 | Can the pharmaceutical industry reduce attrition rates? | Ismail Kola, John Landis | Nat Rev Drug Discov | 2004 | 15286737 | No |
| 3010 | 2657 | 1328.5 | 0.0 | 0.0 | Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. | R R Guillard, J H Ryther | Can J Microbiol | 1962 | 13902807 | Yes |
| 3011 | 2657 | 1328.5 | 75.2 | 37.6 | Heterogeneous photocatalyst materials for water splitting. | Akihiko Kudo, Yugo Miseki | Chem Soc Rev | 2009 | 19088977 | Yes |
| 3012 | 7969 | 1328.2 | 192.0 | 32.0 | Staging of brain pathology related to sporadic Parkinson's disease. | Heiko Braak, Kelly Del Tredici, Udo Rub, Rob A I De Vos, Ernst N H Jansen Steur, Eva Braak | Neurobiol Aging | 2003 | 12498954 | Yes |
| 3013 | 1328 | 1328.0 | 29.4 | 29.4 | VEGF as a key mediator of angiogenesis in cancer. | Peter Carmeliet | Oncology | 2005 | 16301830 | No |
| 3014 | 6638 | 1327.6 | 236.2 | 47.2 | Enzymatic determination of total serum cholesterol. | C C Allain, L S Poon, C S Chan, W Richmond, P C Fu | Clin Chem | 1974 | 4818200 | Yes |
| 3015 | 1327 | 1327.0 | 63.7 | 63.7 | New norms of upper limb fat and muscle areas for assessment of nutritional status. | A R Frisancho | Am J Clin Nutr | 1981 | 6975564 | Yes |
| 3016 | 1326 | 1326.0 | 46.0 | 46.0 | Social support and health: a review of physiological processes potentially underlying links to disease outcomes. | Bert N Uchino | J Behav Med | 2006 | 16758315 | No |
| 3017 | 1326 | 1326.0 | 38.4 | 38.4 | Production and scavenging of reactive oxygen species in chloroplasts and their functions. | Kozi Asada | Plant Physiol | 2006 | 16760493 | Yes |
| 3018 | 1326 | 1326.0 | 40.5 | 40.5 | pegas: an R package for population genetics with an integrated-modular approach. | Emmanuel Paradis | Bioinformatics | 2010 | 20080509 | Yes |
| 3019 | 2652 | 1326.0 | 86.5 | 43.2 | Infernal 1.1: 100-fold faster RNA homology searches. | Eric P Nawrocki, Sean R Eddy | Bioinformatics | 2013 | 24008419 | Yes |
| 3020 | 3977 | 1325.7 | 100.3 | 33.4 | The p53 tumour suppressor gene. | A J Levine, J Momand, C A Finlay | Nature | 1991 | 2046748 | No |
| 3021 | 2651 | 1325.5 | 58.4 | 29.2 | The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. | J Shine, L Dalgarno | Proc Natl Acad Sci U S A | 1974 | 4598299 | Yes |
| 3022 | 2651 | 1325.5 | 62.4 | 31.2 | Integrins and signal transduction pathways: the road taken. | E A Clark, J S Brugge | Science | 1995 | 7716514 | No |
| 3023 | 3976 | 1325.3 | 115.7 | 38.6 | Development and applications of CRISPR-Cas9 for genome engineering. | Patrick D Hsu, Eric S Lander, Feng Zhang | Cell | 2014 | 24906146 | No |
| 3024 | 2650 | 1325.0 | 105.0 | 52.5 | A simple method to assess exercise behavior in the community. | G Godin, R J Shephard | Can J Appl Sport Sci | 1985 | 4053261 | Yes |
| 3025 | 2650 | 1325.0 | 0.0 | 0.0 | Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. | J Altman, G D Das | J Comp Neurol | 1965 | 5861717 | Yes |
| 3026 | 1325 | 1325.0 | 58.6 | 58.6 | The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. | L S Radloff | J Youth Adolesc | 1991 | 24265004 | Yes |
| 3027 | 3973 | 1324.3 | 95.7 | 31.9 | Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. | Sang-Dong Yoo, Young-Hee Cho, Jen Sheen | Nat Protoc | 2007 | 17585298 | Yes |
| 3028 | 2648 | 1324.0 | 59.0 | 29.5 | The Polycomb complex PRC2 and its mark in life. | Raphael Margueron, Danny Reinberg | Nature | 2011 | 21248841 | No |
| 3029 | 2647 | 1323.5 | 102.4 | 51.2 | Efficacy of the Theory of Planned Behaviour: a meta-analytic review. | C J Armitage, M Conner | Br J Soc Psychol | 2001 | 11795063 | Yes |
| 3030 | 2647 | 1323.5 | 86.3 | 43.1 | Prostaglandins and inflammation. | Emanuela Ricciotti, Garret A FitzGerald | Arterioscler Thromb Vasc Biol | 2011 | 21508345 | No |
| 3031 | 2646 | 1323.0 | 70.5 | 35.2 | Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. | M E Feder, G E Hofmann | Annu Rev Physiol | 1999 | 10099689 | No |
| 3032 | 1322 | 1322.0 | 49.1 | 49.1 | The LMS method for constructing normalized growth standards. | T J Cole | Eur J Clin Nutr | 1990 | 2354692 | Yes |
| 3033 | 1322 | 1322.0 | 88.8 | 88.8 | The problem of rigor in qualitative research. | M Sandelowski | ANS Adv Nurs Sci | 1986 | 3083765 | Yes |
| 3034 | 1322 | 1322.0 | 36.0 | 36.0 | The aryl hydrocarbon receptor complex. | O Hankinson | Annu Rev Pharmacol Toxicol | 1995 | 7598497 | No |
| 3035 | 2644 | 1322.0 | 49.4 | 24.7 | Live or let die: the cell's response to p53. | Karen H Vousden, Xin Lu | Nat Rev Cancer | 2002 | 12154352 | No |
| 3036 | 1322 | 1322.0 | 30.0 | 30.0 | r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. | Michael J Sanderson | Bioinformatics | 2003 | 12538260 | Yes |
| 3037 | 1322 | 1322.0 | 0.0 | 0.0 | A production of amino acids under possible primitive earth conditions. | S L Miller | Science | 1953 | 13056598 | Yes |
| 3038 | 3964 | 1321.3 | 104.7 | 34.9 | Matrix metalloproteinases: regulators of the tumor microenvironment. | Kai Kessenbrock, Vicki Plaks, Zena Werb | Cell | 2010 | 20371345 | No |
| 3039 | 2642 | 1321.0 | 54.8 | 27.4 | ERBB receptors and cancer: the complexity of targeted inhibitors. | Nancy E Hynes, Heidi A Lane | Nat Rev Cancer | 2005 | 15864276 | No |
| 3040 | 1321 | 1321.0 | 38.1 | 38.1 | Rethinking schizophrenia. | Thomas R Insel | Nature | 2010 | 21068826 | No |
| 3041 | 3962 | 1320.7 | 196.4 | 65.5 | In search of how people change. Applications to addictive behaviors. | J O Prochaska, C C DiClemente, J C Norcross | Am Psychol | 1992 | 1329589 | Yes |
| 3042 | 13203 | 1320.3 | 351.4 | 35.1 | Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. | M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, F C Marini, D S Krause, R J Deans, A Keating, D J Prockop, Em Horwitz | Cytotherapy | 2006 | 16923606 | Yes |
| 3043 | 3961 | 1320.3 | 146.2 | 48.7 | Ecological momentary assessment. | Saul Shiffman, Arthur A Stone, Michael R Hufford | Annu Rev Clin Psychol | 2008 | 18509902 | No |
| 3044 | 1320 | 1320.0 | 25.3 | 25.3 | Antigen-specific interaction between T and B cells. | A Lanzavecchia | Nature | 1985 | 3157869 | Yes |
| 3045 | 1320 | 1320.0 | 50.2 | 50.2 | Inhibition and facilitation of nucleic acid amplification. | I G Wilson | Appl Environ Microbiol | 1997 | 9327537 | No |
| 3046 | 3958 | 1319.3 | 141.7 | 47.2 | PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. | J W Varni, M Seid, P S Kurtin | Med Care | 2001 | 11468499 | Yes |
| 3047 | 3957 | 1319.0 | 205.3 | 68.4 | Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. | F Guillemin, C Bombardier, D Beaton | J Clin Epidemiol | 1993 | 8263569 | No |
| 3048 | 1319 | 1319.0 | 35.1 | 35.1 | Primate anterior cingulate cortex: where motor control, drive and cognition interface. | T Paus | Nat Rev Neurosci | 2001 | 11389475 | No |
| 3049 | 1319 | 1319.0 | 38.7 | 38.7 | Transcranial magnetic stimulation: a primer. | Mark Hallett | Neuron | 2007 | 17640522 | No |
| 3050 | 2638 | 1319.0 | 99.8 | 49.9 | Comparative Protein Structure Modeling Using MODELLER. | Benjamin Webb, Andrej Sali | Curr Protoc Bioinformatics | 2016 | 27322406 | Yes |
| 3051 | 2637 | 1318.5 | 0.0 | 0.0 | Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. | H A Edmondson, P E Steiner | Cancer | 1954 | 13160935 | Yes |
| 3052 | 2637 | 1318.5 | 67.1 | 33.5 | Toxoplasmosis. | J G Montoya, O Liesenfeld | Lancet | 2004 | 15194258 | No |
| 3053 | 1318 | 1318.0 | 0.0 | 0.0 | Autistic disturbances of affective contact. | L Kanner | Acta Paedopsychiatr | 1968 | 4880460 | Yes |
| 3054 | 1318 | 1318.0 | 49.3 | 49.3 | Risk and maintenance factors for eating pathology: a meta-analytic review. | Eric Stice | Psychol Bull | 2002 | 12206196 | No |
| 3055 | 1318 | 1318.0 | 35.9 | 35.9 | Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. | Earl S Ford | Diabetes Care | 2005 | 15983333 | No |
| 3056 | 2634 | 1317.0 | 76.6 | 38.3 | Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. | I Chopra, M Roberts | Microbiol Mol Biol Rev | 2001 | 11381101 | Yes |
| 3057 | 1317 | 1317.0 | 29.3 | 29.3 | Molecular physiology of low-voltage-activated t-type calcium channels. | Edward Perez-Reyes | Physiol Rev | 2003 | 12506128 | No |
| 3058 | 1317 | 1317.0 | 31.3 | 31.3 | Refined structure of the nicotinic acetylcholine receptor at 4A resolution. | Nigel Unwin | J Mol Biol | 2005 | 15701510 | Yes |
| 3059 | 1317 | 1317.0 | 52.0 | 52.0 | Intention-to-treat concept: A review. | Sandeep K Gupta | Perspect Clin Res | 2011 | 21897887 | Yes |
| 3060 | 2633 | 1316.5 | 43.4 | 21.7 | Genetic transformation of Drosophila with transposable element vectors. | G M Rubin, A C Spradling | Science | 1982 | 6289436 | Yes |
| 3061 | 1316 | 1316.0 | 36.1 | 36.1 | Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. | U Mitzdorf | Physiol Rev | 1985 | 3880898 | No |
| 3062 | 1316 | 1316.0 | 35.9 | 35.9 | The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. | R G Gerrity | Am J Pathol | 1981 | 7234961 | Yes |
| 3063 | 3948 | 1316.0 | 111.8 | 37.3 | Molecular characterization of a peripheral receptor for cannabinoids. | S Munro, K L Thomas, M Abu-Shaar | Nature | 1993 | 7689702 | Yes |
| 3064 | 1316 | 1316.0 | 32.4 | 32.4 | Apoptosis in cancer therapy: crossing the threshold. | D E Fisher | Cell | 1994 | 8069905 | No |
| 3065 | 2632 | 1316.0 | 59.4 | 29.7 | Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. | William G Kaelin, Peter J Ratcliffe | Mol Cell | 2008 | 18498744 | No |
| 3066 | 1315 | 1315.0 | 0.0 | 0.0 | Measurement of feelings using visual analogue scales. | R C Aitken | Proc R Soc Med | 1969 | 4899510 | No |
| 3067 | 2630 | 1315.0 | 68.5 | 34.2 | The free radical theory of aging matures. | K B Beckman, B N Ames | Physiol Rev | 1998 | 9562038 | No |
| 3068 | 3945 | 1315.0 | 110.5 | 36.8 | FastTree: computing large minimum evolution trees with profiles instead of a distance matrix. | Morgan N Price, Paramvir S Dehal, Adam P Arkin | Mol Biol Evol | 2009 | 19377059 | Yes |
| 3069 | 2629 | 1314.5 | 83.0 | 41.5 | An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. | Sun Ho Kim, Jin Mo Chung | Pain | 1992 | 1333581 | Yes |
| 3070 | 1314 | 1314.0 | 47.2 | 47.2 | Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. | A J Alpert | J Chromatogr | 1990 | 2324207 | Yes |
| 3071 | 1314 | 1314.0 | 35.3 | 35.3 | Phylogenies from molecular sequences: inference and reliability. | J Felsenstein | Annu Rev Genet | 1988 | 3071258 | No |
| 3072 | 1314 | 1314.0 | 34.2 | 34.2 | Rapid evolution of a protein in vitro by DNA shuffling. | W P Stemmer | Nature | 1994 | 8047147 | Yes |
| 3073 | 1314 | 1314.0 | 32.9 | 32.9 | Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. | P Kuzmic | Anal Biochem | 1996 | 8660575 | Yes |
| 3074 | 1314 | 1314.0 | 32.3 | 32.3 | Papillomavirus infections--a major cause of human cancers. | H Zur Hausen | Biochim Biophys Acta | 1996 | 8876633 | No |
| 3075 | 2628 | 1314.0 | 66.2 | 33.1 | Multipoint quantitative-trait linkage analysis in general pedigrees. | L Almasy, J Blangero | Am J Hum Genet | 1998 | 9545414 | Yes |
| 3076 | 2627 | 1313.5 | 52.5 | 26.2 | CpG islands in vertebrate genomes. | M Gardiner-Garden, M Frommer | J Mol Biol | 1987 | 3656447 | Yes |
| 3077 | 2627 | 1313.5 | 61.0 | 30.5 | Mitochondrial control of cell death. | G Kroemer, J C Reed | Nat Med | 2000 | 10802706 | No |
| 3078 | 2627 | 1313.5 | 113.2 | 56.6 | Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. | Douglas J Morrison, Tom Preston | Gut Microbes | 2016 | 26963409 | No |
| 3079 | 1313 | 1313.0 | 41.3 | 41.3 | Peritonectomy procedures. | P H Sugarbaker | Ann Surg | 1995 | 7826158 | Yes |
| 3080 | 1313 | 1313.0 | 36.1 | 36.1 | The lipocalin protein family: structure and function. | D R Flower | Biochem J | 1996 | 8761444 | No |
| 3081 | 1312 | 1312.0 | 39.4 | 39.4 | The matrix-degrading metalloproteinases. | L M Matrisian | Bioessays | 1992 | 1445287 | No |
| 3082 | 1312 | 1312.0 | 33.1 | 33.1 | Bee and wasp venoms. | E Habermann | Science | 1972 | 4113805 | No |
| 3083 | 1312 | 1312.0 | 29.1 | 29.1 | Double identity for proteins of the Bcl-2 family. | J C Reed | Nature | 1997 | 9194558 | No |
| 3084 | 1312 | 1312.0 | 33.4 | 33.4 | Somatostatin and its receptor family. | Y C Patel | Front Neuroendocrinol | 1999 | 10433861 | No |
| 3085 | 2624 | 1312.0 | 56.1 | 28.1 | Protein aggregation and neurodegenerative disease. | Christopher A Ross, Michelle A Poirier | Nat Med | 2004 | 15272267 | No |
| 3086 | 2624 | 1312.0 | 74.7 | 37.4 | Increasing incidence of thyroid cancer in the United States, 1973-2002. | Louise Davies, H Gilbert Welch | JAMA | 2006 | 16684987 | Yes |
| 3087 | 1312 | 1312.0 | 27.1 | 27.1 | Protein tyrosine phosphatases: from genes, to function, to disease. | Nicholas K Tonks | Nat Rev Mol Cell Biol | 2006 | 17057753 | No |
| 3088 | 1311 | 1311.0 | 38.5 | 38.5 | Experience from a multicentre stroke register: a preliminary report. | S Hatano | Bull World Health Organ | 1976 | 1088404 | Yes |
| 3089 | 1311 | 1311.0 | 0.0 | 0.0 | Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. | G D Winter | Nature | 1962 | 14007593 | Yes |
| 3090 | 1311 | 1311.0 | 36.5 | 36.5 | Thermo- and pH-responsive polymers in drug delivery. | Dirk Schmaljohann | Adv Drug Deliv Rev | 2006 | 17125884 | No |
| 3091 | 3931 | 1310.3 | 86.8 | 28.9 | A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. | R Medzhitov, P Preston-Hurlburt, C A Janeway | Nature | 1997 | 9237759 | Yes |
| 3092 | 1310 | 1310.0 | 22.9 | 22.9 | Clonal selection and learning in the antibody system. | K Rajewsky | Nature | 1996 | 8657279 | No |
| 3093 | 1310 | 1310.0 | 46.1 | 46.1 | Volumetric modulated arc therapy: IMRT in a single gantry arc. | Karl Otto | Med Phys | 2008 | 18293586 | Yes |
| 3094 | 2620 | 1310.0 | 77.2 | 38.6 | Are the dorsal and ventral hippocampus functionally distinct structures? | Michael S Fanselow, Hong-Wei Dong | Neuron | 2010 | 20152109 | No |
| 3095 | 1310 | 1310.0 | 0.0 | 0.0 | Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. | P F Scholander | J Biol Chem | 1947 | 20281644 | Yes |
| 3096 | 3929 | 1309.7 | 103.2 | 34.4 | Thresholding of statistical maps in functional neuroimaging using the false discovery rate. | Christopher R Genovese, Nicole A Lazar, Thomas Nichols | Neuroimage | 2002 | 11906227 | Yes |
| 3097 | 2619 | 1309.5 | 0.0 | 0.0 | Immunization of dissociated spleen cell cultures from normal mice. | R I Mishell, R W Dutton | J Exp Med | 1967 | 6034749 | Yes |
| 3098 | 1309 | 1309.0 | 54.2 | 54.2 | A simple method for determination of serum catalase activity and revision of reference range. | L Goth | Clin Chim Acta | 1991 | 2029780 | Yes |
| 3099 | 2618 | 1309.0 | 61.2 | 30.6 | Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. | E Y Chen, P H Seeburg | DNA | 1985 | 3996185 | Yes |
| 3100 | 2618 | 1309.0 | 47.4 | 23.7 | Stats: transcriptional control and biological impact. | David E Levy, J E Darnell | Nat Rev Mol Cell Biol | 2002 | 12209125 | No |
| 3101 | 1309 | 1309.0 | 49.6 | 49.6 | Considerations in determining sample size for pilot studies. | Melody A Hertzog | Res Nurs Health | 2008 | 18183564 | No |
| 3102 | 10468 | 1308.5 | 362.5 | 45.3 | Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. | V J Felitti, R F Anda, D Nordenberg, D F Williamson, A M Spitz, V Edwards, M P Koss, J S Marks | Am J Prev Med | 1998 | 9635069 | Yes |
| 3103 | 2616 | 1308.0 | 54.6 | 27.3 | The molecular biology of axon guidance. | M Tessier-Lavigne, C S Goodman | Science | 1996 | 8895455 | No |
| 3104 | 1308 | 1308.0 | 60.7 | 60.7 | The anatomy of stages of change. | A Bandura | Am J Health Promot | 1997 | 10170438 | No |
| 3105 | 1308 | 1308.0 | 35.6 | 35.6 | Disorders of iron metabolism. | N C Andrews | N Engl J Med | 1999 | 10607817 | No |
| 3106 | 1308 | 1308.0 | 26.7 | 26.7 | Basement membranes: structure, assembly and role in tumour angiogenesis. | Raghu Kalluri | Nat Rev Cancer | 2003 | 12778132 | No |
| 3107 | 2616 | 1308.0 | 73.8 | 36.9 | A neurotrophic model for stress-related mood disorders. | Ronald S Duman, Lisa M Monteggia | Biol Psychiatry | 2006 | 16631126 | No |
| 3108 | 1308 | 1308.0 | 28.2 | 28.2 | The roles of intracellular protein-degradation pathways in neurodegeneration. | David C Rubinsztein | Nature | 2006 | 17051204 | No |
| 3109 | 1307 | 1307.0 | 25.0 | 25.0 | NK cell receptors. | L L Lanier | Annu Rev Immunol | 1998 | 9597134 | No |
| 3110 | 1307 | 1307.0 | 27.6 | 27.6 | Microsatellites: simple sequences with complex evolution. | Hans Ellegren | Nat Rev Genet | 2004 | 15153996 | No |
| 3111 | 1307 | 1307.0 | 27.4 | 27.4 | Understanding the odd science of aging. | Thomas B L Kirkwood | Cell | 2005 | 15734677 | No |
| 3112 | 1307 | 1307.0 | 37.4 | 37.4 | Phosphoinositides: tiny lipids with giant impact on cell regulation. | Tamas Balla | Physiol Rev | 2013 | 23899561 | No |
| 3113 | 2613 | 1306.5 | 94.3 | 47.1 | Antiseptics and disinfectants: activity, action, and resistance. | G McDonnell, A D Russell | Clin Microbiol Rev | 1999 | 9880479 | No |
| 3114 | 1306 | 1306.0 | 0.0 | 0.0 | Agammaglobulinemia. | O C Bruton | Pediatrics | 1952 | 14929630 | Yes |
| 3115 | 1306 | 1306.0 | 33.3 | 33.3 | Identifying and characterizing binding sites and assessing druggability. | Thomas A Halgren | J Chem Inf Model | 2009 | 19434839 | Yes |
| 3116 | 1306 | 1306.0 | 34.8 | 34.8 | AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. | D Grahame Hardie | Genes Dev | 2011 | 21937710 | No |
| 3117 | 1306 | 1306.0 | 36.8 | 36.8 | Serine, glycine and one-carbon units: cancer metabolism in full circle. | Jason W Locasale | Nat Rev Cancer | 2013 | 23822983 | No |
| 3118 | 11746 | 1305.1 | 304.0 | 33.8 | Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. | Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J Van Baren, Steven L Salzberg, Barbara J Wold, Lior Pachter | Nat Biotechnol | 2010 | 20436464 | Yes |
| 3119 | 1305 | 1305.0 | 29.8 | 29.8 | Chemistry and biology of the immunophilins and their immunosuppressive ligands. | S L Schreiber | Science | 1991 | 1702904 | No |
| 3120 | 1305 | 1305.0 | 0.0 | 0.0 | Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. | W W Douglas | Br J Pharmacol | 1968 | 4882190 | No |
| 3121 | 1305 | 1305.0 | 0.0 | 0.0 | A quantitative immunochemical measure of the primary interaction between I BSA and antibody. | R S Farr | J Infect Dis | 1958 | 13611294 | Yes |
| 3122 | 1305 | 1305.0 | 39.3 | 39.3 | What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. | Michael A Babyak | Psychosom Med | 2004 | 15184705 | Yes |
| 3123 | 2609 | 1304.5 | 122.6 | 61.3 | Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. | G Atkinson, A M Nevill | Sports Med | 1998 | 9820922 | No |
| 3124 | 1304 | 1304.0 | 62.3 | 62.3 | A cognitive approach to panic. | D M Clark | Behav Res Ther | 1986 | 3741311 | Yes |
| 3125 | 1304 | 1304.0 | 35.4 | 35.4 | Drug delivery and targeting. | R Langer | Nature | 1998 | 9579855 | No |
| 3126 | 1304 | 1304.0 | 39.0 | 39.0 | Philosophical conceptions of the self: implications for cognitive science. | Shaun Gallagher | Trends Cogn Sci | 2000 | 10637618 | Yes |
| 3127 | 1304 | 1304.0 | 31.6 | 31.6 | Oxidative stress in neurodegeneration: cause or consequence? | Julie K Andersen | Nat Med | 2004 | 15298006 | No |
| 3128 | 2608 | 1304.0 | 65.8 | 32.9 | Endometriosis. | Linda C Giudice, Lee C Kao | Lancet | 2004 | 15541453 | No |
| 3129 | 1304 | 1304.0 | 26.1 | 26.1 | Up on the tightrope: natural killer cell activation and inhibition. | Lewis L Lanier | Nat Immunol | 2008 | 18425106 | No |
| 3130 | 2608 | 1304.0 | 101.7 | 50.9 | Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. | Jerome Galon, Daniela Bruni | Nat Rev Drug Discov | 2019 | 30610226 | No |
| 3131 | 9127 | 1303.9 | 260.4 | 37.2 | Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. | , Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur Wheeler | N Engl J Med | 2000 | 10793162 | Yes |
| 3132 | 2606 | 1303.0 | 66.0 | 33.0 | Epidermal growth factor. | G Carpenter, S Cohen | Annu Rev Biochem | 1979 | 382984 | No |
| 3133 | 2606 | 1303.0 | 75.0 | 37.5 | Regulation of type I interferon responses. | Lionel B Ivashkiv, Laura T Donlin | Nat Rev Immunol | 2014 | 24362405 | No |
| 3134 | 2605 | 1302.5 | 51.2 | 25.6 | Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. | C W Greider, E H Blackburn | Cell | 1985 | 3907856 | Yes |
| 3135 | 2605 | 1302.5 | 51.4 | 25.7 | Gene silencing in cancer in association with promoter hypermethylation. | James G Herman, Stephen B Baylin | N Engl J Med | 2003 | 14627790 | No |
| 3136 | 1302 | 1302.0 | 43.2 | 43.2 | The somatic marker hypothesis and the possible functions of the prefrontal cortex. | A R Damasio | Philos Trans R Soc Lond B Biol Sci | 1996 | 8941953 | No |
| 3137 | 1302 | 1302.0 | 42.1 | 42.1 | Varieties of impulsivity. | J L Evenden | Psychopharmacology (Berl) | 1999 | 10550486 | No |
| 3138 | 1302 | 1302.0 | 33.4 | 33.4 | Ovarian cancer development and metastasis. | Ernst Lengyel | Am J Pathol | 2010 | 20651229 | Yes |
| 3139 | 1302 | 1302.0 | 59.3 | 59.3 | A decade of immune-checkpoint inhibitors in cancer therapy. | Caroline Robert | Nat Commun | 2020 | 32732879 | Yes |
| 3140 | 3903 | 1301.0 | 99.9 | 33.3 | Global and societal implications of the diabetes epidemic. | P Zimmet, K G Alberti, J Shaw | Nature | 2001 | 11742409 | No |
| 3141 | 1301 | 1301.0 | 29.9 | 29.9 | Serine protease mechanism and specificity. | Lizbeth Hedstrom | Chem Rev | 2002 | 12475199 | No |
| 3142 | 2602 | 1301.0 | 54.8 | 27.4 | Regulation of translation initiation in eukaryotes: mechanisms and biological targets. | Nahum Sonenberg, Alan G Hinnebusch | Cell | 2009 | 19239892 | No |
| 3143 | 2601 | 1300.5 | 64.0 | 32.0 | Regulation of wound healing by growth factors and cytokines. | Sabine Werner, Richard Grose | Physiol Rev | 2003 | 12843410 | No |
| 3144 | 14302 | 1300.2 | 280.1 | 25.5 | Model-based analysis of ChIP-Seq (MACS). | Yong Zhang, Tao Liu, Clifford A Meyer, Jerome Eeckhoute, David S Johnson, Bradley E Bernstein, Chad Nusbaum, Richard M Myers, Myles Brown, Wei Li, X Shirley Liu | Genome Biol | 2008 | 18798982 | Yes |
| 3145 | 1300 | 1300.0 | 32.9 | 32.9 | A tension-based theory of morphogenesis and compact wiring in the central nervous system. | D C Van Essen | Nature | 1997 | 9002514 | Yes |
| 3146 | 1300 | 1300.0 | 28.9 | 28.9 | Epstein-Barr virus infection. | J I Cohen | N Engl J Med | 2000 | 10944566 | No |
| 3147 | 1300 | 1300.0 | 30.3 | 30.3 | S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. | R Donato | Int J Biochem Cell Biol | 2001 | 11390274 | No |
| 3148 | 1300 | 1300.0 | 86.3 | 86.3 | Multicollinearity and misleading statistical results. | Jong Hae Kim | Korean J Anesthesiol | 2019 | 31304696 | Yes |
| 3149 | 2599 | 1299.5 | 47.2 | 23.6 | The DNA damage response: putting checkpoints in perspective. | B B Zhou, S J Elledge | Nature | 2000 | 11100718 | No |
| 3150 | 2599 | 1299.5 | 70.1 | 35.0 | Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. | Patrick S Ward, Craig B Thompson | Cancer Cell | 2012 | 22439925 | No |
| 3151 | 1299 | 1299.0 | 40.4 | 40.4 | Pectin structure and biosynthesis. | Debra Mohnen | Curr Opin Plant Biol | 2008 | 18486536 | No |
| 3152 | 2597 | 1298.5 | 50.0 | 25.0 | The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. | T Maehama, J E Dixon | J Biol Chem | 1998 | 9593664 | Yes |
| 3153 | 1298 | 1298.0 | 27.6 | 27.6 | The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequences. | P Stothard | Biotechniques | 2000 | 10868275 | Yes |
| 3154 | 3893 | 1297.7 | 99.5 | 33.2 | Methods in mammalian autophagy research. | Noboru Mizushima, Tamotsu Yoshimori, Beth Levine | Cell | 2010 | 20144757 | Yes |
| 3155 | 5190 | 1297.5 | 116.5 | 29.1 | Interleukin-10 and the interleukin-10 receptor. | K W Moore, R De Waal Malefyt, R L Coffman, A O'Garra | Annu Rev Immunol | 2001 | 11244051 | No |
| 3156 | 2595 | 1297.5 | 56.8 | 28.4 | Blinded by the Light: The Growing Complexity of p53. | Karen H Vousden, Carol Prives | Cell | 2009 | 19410540 | No |
| 3157 | 1297 | 1297.0 | 41.1 | 41.1 | Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. | J H Luft | Anat Rec | 1971 | 4108333 | Yes |
| 3158 | 1297 | 1297.0 | 32.5 | 32.5 | Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. | J Deisenhofer | Biochemistry | 1981 | 7236608 | Yes |
| 3159 | 1297 | 1297.0 | 37.5 | 37.5 | A theory of magnitude: common cortical metrics of time, space and quantity. | Vincent Walsh | Trends Cogn Sci | 2003 | 14585444 | Yes |
| 3160 | 2594 | 1297.0 | 73.4 | 36.7 | Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. | Marie Cargnello, Philippe P Roux | Microbiol Mol Biol Rev | 2011 | 21372320 | No |
| 3161 | 1296 | 1296.0 | 32.2 | 32.2 | Receptors for epidermal growth factor and other polypeptide mitogens. | G Carpenter | Annu Rev Biochem | 1987 | 3039909 | No |
| 3162 | 2592 | 1296.0 | 170.0 | 85.0 | The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. | Hussin A Rothan, Siddappa N Byrareddy | J Autoimmun | 2020 | 32113704 | No |
| 3163 | 1295 | 1295.0 | 49.2 | 49.2 | Indirect and mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool. | Georgia Salanti | Res Synth Methods | 2012 | 26062083 | Yes |
| 3164 | 2589 | 1294.5 | 79.4 | 39.7 | A simple index of Crohn's-disease activity. | R F Harvey, J M Bradshaw | Lancet | 1980 | 6102236 | Yes |
| 3165 | 2589 | 1294.5 | 76.0 | 38.0 | Accurate molecular van der Waals interactions from ground-state electron density and free-atom reference data. | Alexandre Tkatchenko, Matthias Scheffler | Phys Rev Lett | 2009 | 19257665 | Yes |
| 3166 | 1294 | 1294.0 | 51.1 | 51.1 | The P300 wave of the human event-related potential. | T W Picton | J Clin Neurophysiol | 1992 | 1464675 | No |
| 3167 | 1294 | 1294.0 | 47.8 | 47.8 | Type 2 inflammation in asthma--present in most, absent in many. | John V Fahy | Nat Rev Immunol | 2015 | 25534623 | No |
| 3168 | 1294 | 1294.0 | 66.0 | 66.0 | Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. | Hector F Escobar-Morreale | Nat Rev Endocrinol | 2018 | 29569621 | No |
| 3169 | 1293 | 1293.0 | 0.0 | 0.0 | Electrophoretic separation of plasma lipoproteins in agarose gel. | R P Noble | J Lipid Res | 1968 | 4176473 | Yes |
| 3170 | 1293 | 1293.0 | 20.9 | 20.9 | A restriction point for control of normal animal cell proliferation. | A B Pardee | Proc Natl Acad Sci U S A | 1974 | 4524638 | Yes |
| 3171 | 7757 | 1292.8 | 299.8 | 50.0 | GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. | Zefang Tang, Chenwei Li, Boxi Kang, Ge Gao, Cheng Li, Zemin Zhang | Nucleic Acids Res | 2017 | 28407145 | Yes |
| 3172 | 3878 | 1292.7 | 98.8 | 32.9 | Mechanisms linking obesity to insulin resistance and type 2 diabetes. | Steven E Kahn, Rebecca L Hull, Kristina M Utzschneider | Nature | 2006 | 17167471 | No |
| 3173 | 2585 | 1292.5 | 54.8 | 27.4 | NF-kappaB: linking inflammation and immunity to cancer development and progression. | Michael Karin, Florian R Greten | Nat Rev Immunol | 2005 | 16175180 | No |
| 3174 | 2584 | 1292.0 | 107.4 | 53.7 | The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. | R Naatanen, T Picton | Psychophysiology | 1987 | 3615753 | Yes |
| 3175 | 1292 | 1292.0 | 33.2 | 33.2 | Reactive oxygen radicals in signaling and damage in the ischemic brain. | P H Chan | J Cereb Blood Flow Metab | 2001 | 11149664 | No |
| 3176 | 1292 | 1292.0 | 37.3 | 37.3 | Epidemiology of women and depression. | Ronald C Kessler | J Affect Disord | 2003 | 12646294 | Yes |
| 3177 | 1292 | 1292.0 | 52.0 | 52.0 | Bisphenol A and human health: a review of the literature. | Johanna R Rochester | Reprod Toxicol | 2013 | 23994667 | No |
| 3178 | 2583 | 1291.5 | 54.1 | 27.1 | Sequence logos: a new way to display consensus sequences. | T D Schneider, R M Stephens | Nucleic Acids Res | 1990 | 2172928 | Yes |
| 3179 | 2583 | 1291.5 | 64.4 | 32.2 | Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations. | In Suk Joung, Thomas E Cheatham | J Phys Chem B | 2008 | 18593145 | Yes |
| 3180 | 1291 | 1291.0 | 24.4 | 24.4 | CD95's deadly mission in the immune system. | P H Krammer | Nature | 2000 | 11048730 | No |
| 3181 | 1291 | 1291.0 | 36.9 | 36.9 | Neural systems for recognizing emotion. | Ralph Adolphs | Curr Opin Neurobiol | 2002 | 12015233 | No |
| 3182 | 1291 | 1291.0 | 42.5 | 42.5 | Socioeconomic status and obesity. | Lindsay McLaren | Epidemiol Rev | 2007 | 17478442 | No |
| 3183 | 1291 | 1291.0 | 45.8 | 45.8 | Human milk oligosaccharides: every baby needs a sugar mama. | Lars Bode | Glycobiology | 2012 | 22513036 | No |
| 3184 | 2580 | 1290.0 | 65.6 | 32.8 | Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. | A Warshel, M Levitt | J Mol Biol | 1976 | 985660 | Yes |
| 3185 | 1290 | 1290.0 | 30.7 | 30.7 | Brain tumors. | L M DeAngelis | N Engl J Med | 2001 | 11150363 | No |
| 3186 | 1290 | 1290.0 | 30.6 | 30.6 | Production of recombinant protein therapeutics in cultivated mammalian cells. | Florian M Wurm | Nat Biotechnol | 2004 | 15529164 | No |
| 3187 | 1290 | 1290.0 | 36.3 | 36.3 | Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. | Paul Willner | Neuropsychobiology | 2005 | 16037678 | No |
| 3188 | 1290 | 1290.0 | 104.6 | 104.6 | Complex heatmap visualization. | Zuguang Gu | Imeta | 2022 | 38868715 | Yes |
| 3189 | 2577 | 1288.5 | 76.7 | 38.4 | Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. | Xiaobo Chen, Samuel S Mao | Chem Rev | 2007 | 17590053 | Yes |
| 3190 | 2576 | 1288.0 | 71.0 | 35.5 | Regulatory sequences involved in the promotion and termination of RNA transcription. | M Rosenberg, D Court | Annu Rev Genet | 1979 | 94251 | No |
| 3191 | 1287 | 1287.0 | 0.0 | 0.0 | Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. | A Boyum | Scand J Clin Lab Invest Suppl | 1968 | 4179066 | Yes |
| 3192 | 1287 | 1287.0 | 40.7 | 40.7 | Somatostatin. | S Reichlin | N Engl J Med | 1983 | 6139753 | No |
| 3193 | 1287 | 1287.0 | 33.3 | 33.3 | Context and behavioral processes in extinction. | Mark E Bouton | Learn Mem | 2004 | 15466298 | No |
| 3194 | 1287 | 1287.0 | 31.6 | 31.6 | ImageJ for microscopy. | Tony J Collins | Biotechniques | 2007 | 17936939 | No |
| 3195 | 2573 | 1286.5 | 63.2 | 31.6 | Production of single-stranded plasmid DNA. | J Vieira, J Messing | Methods Enzymol | 1987 | 3323803 | Yes |
| 3196 | 1286 | 1286.0 | 39.9 | 39.9 | Diversity and ubiquity of K channels. | B Rudy | Neuroscience | 1988 | 2457185 | No |
| 3197 | 1286 | 1286.0 | 29.4 | 29.4 | Microglia as a source and target of cytokines. | Uwe-Karsten Hanisch | Glia | 2002 | 12379902 | No |
| 3198 | 1286 | 1286.0 | 30.4 | 30.4 | Viruses in the sea. | Curtis A Suttle | Nature | 2005 | 16163346 | No |
| 3199 | 1286 | 1286.0 | 36.4 | 36.4 | Neurophysiological and computational principles of cortical rhythms in cognition. | Xiao-Jing Wang | Physiol Rev | 2010 | 20664082 | No |
| 3200 | 7715 | 1285.8 | 181.9 | 30.3 | Enzymatic assembly of DNA molecules up to several hundred kilobases. | Daniel G Gibson, Lei Young, Ray-Yuan Chuang, J Craig Venter, Clyde A Hutchison, Hamilton O Smith | Nat Methods | 2009 | 19363495 | Yes |
| 3201 | 1285 | 1285.0 | 39.8 | 39.8 | Analyzing the mosaic structure of genes. | J M Smith | J Mol Evol | 1992 | 1556748 | No |
| 3202 | 1284 | 1284.0 | 33.9 | 33.9 | Bile acids: regulation of synthesis. | John Y L Chiang | J Lipid Res | 2009 | 19346330 | No |
| 3203 | 6419 | 1283.8 | 200.5 | 40.1 | Biodiversity hotspots for conservation priorities. | N Myers, R A Mittermeier, C G Mittermeier, G A Da Fonseca, J Kent | Nature | 2000 | 10706275 | Yes |
| 3204 | 2567 | 1283.5 | 87.4 | 43.7 | Atomic structure and chemistry of human serum albumin. | X M He, D C Carter | Nature | 1992 | 1630489 | Yes |
| 3205 | 2567 | 1283.5 | 48.8 | 24.4 | Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. | M Fried, D M Crothers | Nucleic Acids Res | 1981 | 6275366 | Yes |
| 3206 | 2567 | 1283.5 | 0.0 | 0.0 | Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. | G J Todaro, H Green | J Cell Biol | 1963 | 13985244 | Yes |
| 3207 | 1283 | 1283.0 | 0.0 | 0.0 | The effective period of preventive antibiotic action in experimental incisions and dermal lesions. | J F Burke | Surgery | 1961 | 16722001 | Yes |
| 3208 | 2565 | 1282.5 | 51.0 | 25.5 | Dynamic instability of microtubule growth. | T Mitchison, M Kirschner | Nature | 1984 | 6504138 | Yes |
| 3209 | 7694 | 1282.3 | 179.7 | 29.9 | Principal components analysis corrects for stratification in genome-wide association studies. | Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich | Nat Genet | 2006 | 16862161 | Yes |
| 3210 | 2564 | 1282.0 | 55.2 | 27.6 | Establishment and characterization of a human histiocytic lymphoma cell line (U-937). | C Sundstrom, K Nilsson | Int J Cancer | 1976 | 178611 | Yes |
| 3211 | 5128 | 1282.0 | 151.5 | 37.9 | Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. | N Weidner, J P Semple, W R Welch, J Folkman | N Engl J Med | 1991 | 1701519 | Yes |
| 3212 | 2564 | 1282.0 | 63.1 | 31.6 | ZINC--a free database of commercially available compounds for virtual screening. | John J Irwin, Brian K Shoichet | J Chem Inf Model | 2005 | 15667143 | Yes |
| 3213 | 1282 | 1282.0 | 44.7 | 44.7 | DREADDs for Neuroscientists. | Bryan L Roth | Neuron | 2016 | 26889809 | No |
| 3214 | 1281 | 1281.0 | 43.7 | 43.7 | Agents that increase the permeability of the outer membrane. | M Vaara | Microbiol Rev | 1992 | 1406489 | No |
| 3215 | 1281 | 1281.0 | 0.0 | 0.0 | The antidiuretic hormone and the factors which determine its release. | E B Verney | Proc R Soc Lond B Biol Sci | 1947 | 18918876 | Yes |
| 3216 | 5121 | 1280.2 | 122.5 | 30.6 | Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. | G L Wang, B H Jiang, E A Rue, G L Semenza | Proc Natl Acad Sci U S A | 1995 | 7539918 | Yes |
| 3217 | 1280 | 1280.0 | 25.3 | 25.3 | Evolution of ageing. | T B Kirkwood | Nature | 1977 | 593350 | Yes |
| 3218 | 1280 | 1280.0 | 36.4 | 36.4 | Normalization of cell responses in cat striate cortex. | D J Heeger | Vis Neurosci | 1992 | 1504027 | Yes |
| 3219 | 1280 | 1280.0 | 0.0 | 0.0 | Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. | H M Kalckar | J Biol Chem | 1947 | 20285041 | Yes |
| 3220 | 1279 | 1279.0 | 33.1 | 33.1 | An introduction to data reduction: space-group determination, scaling and intensity statistics. | Philip R Evans | Acta Crystallogr D Biol Crystallogr | 2011 | 21460446 | Yes |
| 3221 | 3836 | 1278.7 | 120.9 | 40.3 | Oxidants, antioxidants, and the degenerative diseases of aging. | B N Ames, M K Shigenaga, T M Hagen | Proc Natl Acad Sci U S A | 1993 | 8367443 | No |
| 3222 | 1278 | 1278.0 | 24.0 | 24.0 | Biological robustness. | Hiroaki Kitano | Nat Rev Genet | 2004 | 15520792 | No |
| 3223 | 1278 | 1278.0 | 27.4 | 27.4 | Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. | Michael Forgac | Nat Rev Mol Cell Biol | 2007 | 17912264 | No |
| 3224 | 3832 | 1277.3 | 115.7 | 38.6 | SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. | Manolo Gouy, Stephane Guindon, Olivier Gascuel | Mol Biol Evol | 2010 | 19854763 | Yes |
| 3225 | 1277 | 1277.0 | 36.7 | 36.7 | A human model of gastric carcinogenesis. | P Correa | Cancer Res | 1988 | 3288329 | No |
| 3226 | 1277 | 1277.0 | 0.0 | 0.0 | Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. | J O Holloszy | J Biol Chem | 1967 | 4290225 | Yes |
| 3227 | 1277 | 1277.0 | 23.3 | 23.3 | Regulatory T cells: key controllers of immunologic self-tolerance. | S Sakaguchi | Cell | 2000 | 10850488 | No |
| 3228 | 1277 | 1277.0 | 33.6 | 33.6 | Metabolism and functions of glutathione in brain. | R Dringen | Prog Neurobiol | 2000 | 10880854 | No |
| 3229 | 1277 | 1277.0 | 21.7 | 21.7 | Mitotic kinases as regulators of cell division and its checkpoints. | E A Nigg | Nat Rev Mol Cell Biol | 2001 | 11413462 | No |
| 3230 | 1277 | 1277.0 | 60.3 | 60.3 | The expanding regulatory mechanisms and cellular functions of circular RNAs. | Ling-Ling Chen | Nat Rev Mol Cell Biol | 2020 | 32366901 | No |
| 3231 | 3829 | 1276.3 | 195.3 | 65.1 | Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. | Yan Zheng, Sylvia H Ley, Frank B Hu | Nat Rev Endocrinol | 2018 | 29219149 | No |
| 3232 | 1276 | 1276.0 | 62.4 | 62.4 | Coping theory and research: past, present, and future. | R S Lazarus | Psychosom Med | 1993 | 8346332 | No |
| 3233 | 1276 | 1276.0 | 0.0 | 0.0 | The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. | G A Rose | Bull World Health Organ | 1962 | 13974778 | Yes |
| 3234 | 1276 | 1276.0 | 37.4 | 37.4 | Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies. | Masabumi Shibuya | Genes Cancer | 2011 | 22866201 | Yes |
| 3235 | 8929 | 1275.6 | 602.9 | 86.1 | TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data. | Chengjie Chen, Hao Chen, Yi Zhang, Hannah R Thomas, Margaret H Frank, Yehua He, Rui Xia | Mol Plant | 2020 | 32585190 | Yes |
| 3236 | 2551 | 1275.5 | 55.7 | 27.9 | A rapid, sensitive, and specific method for the determination of protein in dilute solution. | W Schaffner, C Weissmann | Anal Biochem | 1973 | 4128882 | Yes |
| 3237 | 5102 | 1275.5 | 147.2 | 36.8 | Toxic potential of materials at the nanolevel. | Andre Nel, Tian Xia, Lutz Madler, Ning Li | Science | 2006 | 16456071 | No |
| 3238 | 1275 | 1275.0 | 46.6 | 46.6 | Cardiovascular and renal actions of dopamine: potential clinical applications. | L I Goldberg | Pharmacol Rev | 1972 | 4554480 | No |
| 3239 | 1275 | 1275.0 | 25.6 | 25.6 | A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. | Xuemei Chen | Science | 2004 | 12893888 | Yes |
| 3240 | 1275 | 1275.0 | 36.4 | 36.4 | ERK1/2 MAP kinases: structure, function, and regulation. | Robert Roskoski | Pharmacol Res | 2012 | 22569528 | No |
| 3241 | 14024 | 1274.9 | 365.2 | 33.2 | New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. | P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T Van Oosterom, M C Christian, S G Gwyther | J Natl Cancer Inst | 2000 | 10655437 | No |
| 3242 | 2549 | 1274.5 | 67.9 | 34.0 | Nanostructures in biodiagnostics. | Nathaniel L Rosi, Chad A Mirkin | Chem Rev | 2005 | 15826019 | No |
| 3243 | 2549 | 1274.5 | 57.1 | 28.6 | Deep tissue two-photon microscopy. | Fritjof Helmchen, Winfried Denk | Nat Methods | 2005 | 16299478 | No |
| 3244 | 1274 | 1274.0 | 49.1 | 49.1 | Freezing of living cells: mechanisms and implications. | P Mazur | Am J Physiol | 1984 | 6383068 | No |
| 3245 | 1274 | 1274.0 | 38.9 | 38.9 | Peptide antibiotics and their role in innate immunity. | H G Boman | Annu Rev Immunol | 1995 | 7612236 | No |
| 3246 | 2548 | 1274.0 | 101.3 | 50.6 | The Human Intestinal Microbiome in Health and Disease. | Susan V Lynch, Oluf Pedersen | N Engl J Med | 2016 | 27974040 | No |
| 3247 | 2547 | 1273.5 | 97.4 | 48.7 | Gut microbiota, metabolites and host immunity. | Michelle G Rooks, Wendy S Garrett | Nat Rev Immunol | 2016 | 27231050 | No |
| 3248 | 1273 | 1273.0 | 23.5 | 23.5 | Kinesin and dynein superfamily proteins and the mechanism of organelle transport. | N Hirokawa | Science | 1998 | 9438838 | No |
| 3249 | 2545 | 1272.5 | 53.0 | 26.5 | Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. | J A Ledbetter, L A Herzenberg | Immunol Rev | 1979 | 398327 | No |
| 3250 | 2545 | 1272.5 | 63.7 | 31.9 | Peroxisome proliferator-activated receptors: nuclear control of metabolism. | B Desvergne, W Wahli | Endocr Rev | 1999 | 10529898 | No |
| 3251 | 1272 | 1272.0 | 27.8 | 27.8 | Platelets in atherothrombosis. | Zaverio M Ruggeri | Nat Med | 2002 | 12411949 | No |
| 3252 | 2543 | 1271.5 | 90.4 | 45.2 | A formula to estimate the approximate surface area if height and weight be known. 1916. | D Du Bois, E F Du Bois | Nutrition | 1989 | 2520314 | No |
| 3253 | 1271 | 1271.0 | 31.1 | 31.1 | Short-term synaptic plasticity. | R S Zucker | Annu Rev Neurosci | 1989 | 2648947 | No |
| 3254 | 1271 | 1271.0 | 42.9 | 42.9 | Antioxidants in human health and disease. | B Halliwell | Annu Rev Nutr | 1996 | 8839918 | No |
| 3255 | 2542 | 1271.0 | 73.4 | 36.7 | A review of central 5-HT receptors and their function. | N M Barnes, T Sharp | Neuropharmacology | 1999 | 10462127 | No |
| 3256 | 3811 | 1270.3 | 99.7 | 33.2 | Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. | Davis J McCarthy, Yunshun Chen, Gordon K Smyth | Nucleic Acids Res | 2012 | 22287627 | Yes |
| 3257 | 1270 | 1270.0 | 21.2 | 21.2 | Mutation selection and the natural history of cancer. | J Cairns | Nature | 1975 | 1143315 | Yes |
| 3258 | 1270 | 1270.0 | 45.1 | 45.1 | Platelet-rich plasma: evidence to support its use. | Robert E Marx | J Oral Maxillofac Surg | 2004 | 15085519 | No |
| 3259 | 3810 | 1270.0 | 98.2 | 32.7 | The widespread regulation of microRNA biogenesis, function and decay. | Jacek Krol, Inga Loedige, Witold Filipowicz | Nat Rev Genet | 2010 | 20661255 | No |
| 3260 | 2539 | 1269.5 | 59.1 | 29.6 | Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. | D A Brown, J K Rose | Cell | 1992 | 1531449 | Yes |
| 3261 | 2539 | 1269.5 | 186.0 | 93.0 | TYGS is an automated high-throughput platform for state-of-the-art genome-based taxonomy. | Jan P Meier-Kolthoff, Markus Goker | Nat Commun | 2019 | 31097708 | Yes |
| 3262 | 3808 | 1269.3 | 83.0 | 27.7 | 5-fluorouracil: mechanisms of action and clinical strategies. | Daniel B Longley, D Paul Harkin, Patrick G Johnston | Nat Rev Cancer | 2003 | 12724731 | No |
| 3263 | 1269 | 1269.0 | 26.4 | 26.4 | Endocytosis and molecular sorting. | I Mellman | Annu Rev Cell Dev Biol | 1996 | 8970738 | No |
| 3264 | 8881 | 1268.7 | 271.3 | 38.8 | Toxicity and response criteria of the Eastern Cooperative Oncology Group. | M M Oken, R H Creech, D C Tormey, J Horton, T E Davis, E T McFadden, P P Carbone | Am J Clin Oncol | 1982 | 7165009 | Yes |
| 3265 | 2537 | 1268.5 | 81.9 | 41.0 | The capacity of visual working memory for features and conjunctions. | S J Luck, E K Vogel | Nature | 1997 | 9384378 | Yes |
| 3266 | 1268 | 1268.0 | 34.9 | 34.9 | Signaling through phosphatidylcholine breakdown. | J H Exton | J Biol Chem | 1990 | 2104616 | No |
| 3267 | 1268 | 1268.0 | 48.4 | 48.4 | Substance P. | B Pernow | Pharmacol Rev | 1983 | 6196797 | No |
| 3268 | 1268 | 1268.0 | 29.9 | 29.9 | Neurons with graded response have collective computational properties like those of two-state neurons. | J J Hopfield | Proc Natl Acad Sci U S A | 1984 | 6587342 | Yes |
| 3269 | 2536 | 1268.0 | 92.2 | 46.1 | Consensus methods for medical and health services research. | J Jones, D Hunter | BMJ | 1995 | 7640549 | No |
| 3270 | 1268 | 1268.0 | 49.3 | 49.3 | Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? | R S Barbour | BMJ | 2001 | 11337448 | No |
| 3271 | 1268 | 1268.0 | 39.2 | 39.2 | High prevalence of vitamin D inadequacy and implications for health. | Michael F Holick | Mayo Clin Proc | 2006 | 16529140 | No |
| 3272 | 3804 | 1268.0 | 102.8 | 34.3 | Regulation of cancer cell metabolism. | Rob A Cairns, Isaac S Harris, Tak W Mak | Nat Rev Cancer | 2011 | 21258394 | No |
| 3273 | 1268 | 1268.0 | 42.4 | 42.4 | Globalization of diabetes: the role of diet, lifestyle, and genes. | Frank B Hu | Diabetes Care | 2011 | 21617109 | No |
| 3274 | 3802 | 1267.3 | 150.4 | 50.1 | The biology and management of non-small cell lung cancer. | Roy S Herbst, Daniel Morgensztern, Chris Boshoff | Nature | 2018 | 29364287 | No |
| 3275 | 1267 | 1267.0 | 35.7 | 35.7 | Tumor angiogenesis. | J Folkman | Adv Cancer Res | 1985 | 2581424 | No |
| 3276 | 1267 | 1267.0 | 28.1 | 28.1 | An overview of epithelio-mesenchymal transformation. | E D Hay | Acta Anat (Basel) | 1995 | 8714286 | No |
| 3277 | 2533 | 1266.5 | 76.7 | 38.4 | Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. | J I Morgan, T Curran | Annu Rev Neurosci | 1991 | 1903243 | No |
| 3278 | 2533 | 1266.5 | 69.4 | 34.7 | Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. | J L Weber, P E May | Am J Hum Genet | 1989 | 2916582 | Yes |
| 3279 | 12662 | 1266.2 | 433.6 | 43.4 | The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. | N K Aaronson, S Ahmedzai, B Bergman, M Bullinger, A Cull, N J Duez, A Filiberti, H Flechtner, S B Fleishman, J C De Haes | J Natl Cancer Inst | 1993 | 8433390 | Yes |
| 3280 | 2532 | 1266.0 | 137.8 | 68.9 | Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. | S F Dworkin, L LeResche | J Craniomandib Disord | 1992 | 1298767 | No |
| 3281 | 1266 | 1266.0 | 50.5 | 50.5 | A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. | S T Tiffany | Psychol Rev | 1990 | 2186423 | No |
| 3282 | 1266 | 1266.0 | 42.2 | 42.2 | The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. | S Nolen-Hoeksema | J Abnorm Psychol | 2000 | 11016119 | Yes |
| 3283 | 1266 | 1266.0 | 32.1 | 32.1 | Formation and function of the myofibroblast during tissue repair. | Boris Hinz | J Invest Dermatol | 2007 | 17299435 | No |
| 3284 | 1266 | 1266.0 | 39.1 | 39.1 | The multiple-demand (MD) system of the primate brain: mental programs for intelligent behaviour. | John Duncan | Trends Cogn Sci | 2010 | 20171926 | No |
| 3285 | 2531 | 1265.5 | 80.5 | 40.2 | Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. | J E Hixson, D T Vernier | J Lipid Res | 1990 | 2341813 | Yes |
| 3286 | 2531 | 1265.5 | 77.6 | 38.8 | The memory function of sleep. | Susanne Diekelmann, Jan Born | Nat Rev Neurosci | 2010 | 20046194 | No |
| 3287 | 1265 | 1265.0 | 45.1 | 45.1 | Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. | Y Kono | Arch Biochem Biophys | 1978 | 24422 | Yes |
| 3288 | 2529 | 1264.5 | 75.7 | 37.9 | Plasmonics for improved photovoltaic devices. | Harry A Atwater, Albert Polman | Nat Mater | 2010 | 20168344 | Yes |
| 3289 | 1264 | 1264.0 | 63.6 | 63.6 | Self-discrepancy: a theory relating self and affect. | E T Higgins | Psychol Rev | 1987 | 3615707 | Yes |
| 3290 | 1264 | 1264.0 | 30.4 | 30.4 | Model for a quantum Hall effect without Landau levels: Condensed-matter realization of the "parity anomaly" | F D Haldane | Phys Rev Lett | 1988 | 10038961 | Yes |
| 3291 | 1264 | 1264.0 | 28.7 | 28.7 | How neutrophils kill microbes. | Anthony W Segal | Annu Rev Immunol | 2005 | 15771570 | No |
| 3292 | 2528 | 1264.0 | 83.0 | 41.5 | Toll-like receptor signaling pathways. | Takumi Kawasaki, Taro Kawai | Front Immunol | 2014 | 25309543 | No |
| 3293 | 1264 | 1264.0 | 36.5 | 36.5 | Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. | Rakesh K Jain | Cancer Cell | 2014 | 25517747 | No |
| 3294 | 1263 | 1263.0 | 30.7 | 30.7 | Lymphokine production by human T cells in disease states. | S Romagnani | Annu Rev Immunol | 1994 | 8011282 | No |
| 3295 | 1263 | 1263.0 | 26.7 | 26.7 | Searching for genetic determinants in the new millennium. | N J Risch | Nature | 2000 | 10866211 | No |
| 3296 | 2524 | 1262.0 | 65.8 | 32.9 | Pharmacology and functions of metabotropic glutamate receptors. | P J Conn, J P Pin | Annu Rev Pharmacol Toxicol | 1997 | 9131252 | No |
| 3297 | 1262 | 1262.0 | 35.9 | 35.9 | Q-ball imaging. | David S Tuch | Magn Reson Med | 2004 | 15562495 | Yes |
| 3298 | 1262 | 1262.0 | 0.0 | 0.0 | Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. | P B Medawar | Br J Exp Pathol | 1948 | 18865105 | Yes |
| 3299 | 1262 | 1262.0 | 35.1 | 35.1 | MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. | Amy E Pasquinelli | Nat Rev Genet | 2012 | 22411466 | No |
| 3300 | 2523 | 1261.5 | 98.9 | 49.5 | Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. | H Esterbauer, K H Cheeseman | Methods Enzymol | 1990 | 2233308 | Yes |
| 3301 | 1261 | 1261.0 | 25.6 | 25.6 | Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. | R H Schwartz | Cell | 1992 | 1335362 | No |
| 3302 | 1261 | 1261.0 | 48.6 | 48.6 | Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. | R M Post | Am J Psychiatry | 1992 | 1353322 | No |
| 3303 | 1261 | 1261.0 | 40.5 | 40.5 | Invasive aspergillosis. | D W Denning | Clin Infect Dis | 1998 | 9564455 | No |
| 3304 | 1261 | 1261.0 | 29.4 | 29.4 | Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. | H J Dargie | Lancet | 2001 | 11356434 | Yes |
| 3305 | 1261 | 1261.0 | 25.2 | 25.2 | Telomeres and human disease: ageing, cancer and beyond. | Maria A Blasco | Nat Rev Genet | 2005 | 16136653 | No |
| 3306 | 1261 | 1261.0 | 43.4 | 43.4 | Dual-processing accounts of reasoning, judgment, and social cognition. | Jonathan S T B T Evans | Annu Rev Psychol | 2008 | 18154502 | No |
| 3307 | 1260 | 1260.0 | 39.2 | 39.2 | MOPAC: a semiempirical molecular orbital program. | J J Stewart | J Comput Aided Mol Des | 1990 | 2197373 | No |
| 3308 | 1260 | 1260.0 | 24.0 | 24.0 | Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. | Ricky W Johnstone | Nat Rev Drug Discov | 2002 | 12120280 | No |
| 3309 | 1260 | 1260.0 | 28.3 | 28.3 | The myofibroblast in wound healing and fibrocontractive diseases. | G Gabbiani | J Pathol | 2003 | 12845617 | No |
| 3310 | 1260 | 1260.0 | 28.6 | 28.6 | Nuclear factor-kappaB: the enemy within. | Bharat B Aggarwal | Cancer Cell | 2004 | 15380510 | No |
| 3311 | 3779 | 1259.7 | 180.2 | 60.1 | The NLRP3 inflammasome: molecular activation and regulation to therapeutics. | Karen V Swanson, Meng Deng, Jenny P Y Ting | Nat Rev Immunol | 2019 | 31036962 | No |
| 3312 | 2519 | 1259.5 | 112.7 | 56.4 | Network analysis: an integrative approach to the structure of psychopathology. | Denny Borsboom, Angelique O J Cramer | Annu Rev Clin Psychol | 2013 | 23537483 | No |
| 3313 | 3778 | 1259.3 | 93.3 | 31.1 | Marginal structural models and causal inference in epidemiology. | J M Robins, M A Hernan, B Brumback | Epidemiology | 2000 | 10955408 | Yes |
| 3314 | 6296 | 1259.2 | 218.0 | 43.6 | A simulation study of the number of events per variable in logistic regression analysis. | P Peduzzi, J Concato, E Kemper, T R Holford, A R Feinstein | J Clin Epidemiol | 1996 | 8970487 | Yes |
| 3315 | 2518 | 1259.0 | 65.0 | 32.5 | Sulforhodamine B colorimetric assay for cytotoxicity screening. | Vanicha Vichai, Kanyawim Kirtikara | Nat Protoc | 2006 | 17406391 | Yes |
| 3316 | 6292 | 1258.4 | 121.6 | 24.3 | The protein kinase complement of the human genome. | G Manning, D B Whyte, R Martinez, T Hunter, S Sudarsanam | Science | 2002 | 12471243 | No |
| 3317 | 2516 | 1258.0 | 72.5 | 36.2 | Nitric oxide synthases: roles, tolls, and controls. | C Nathan, Q W Xie | Cell | 1994 | 7522969 | No |
| 3318 | 1258 | 1258.0 | 26.4 | 26.4 | Signal transduction via the MAP kinases: proceed at your own RSK. | J Blenis | Proc Natl Acad Sci U S A | 1993 | 8392180 | No |
| 3319 | 1258 | 1258.0 | 35.0 | 35.0 | Low density lipoprotein oxidation and its pathobiological significance. | D Steinberg | J Biol Chem | 1997 | 9261091 | No |
| 3320 | 1258 | 1258.0 | 45.1 | 45.1 | The mental health continuum: from languishing to flourishing in life. | Corey L M Keyes | J Health Soc Behav | 2002 | 12096700 | Yes |
| 3321 | 1258 | 1258.0 | 0.0 | 0.0 | A modification of receptor theory. | R P Stephenson | Br J Pharmacol Chemother | 1956 | 13383117 | Yes |
| 3322 | 1258 | 1258.0 | 35.1 | 35.1 | Stronger Brønsted acids. | Takahiko Akiyama | Chem Rev | 2007 | 17983247 | Yes |
| 3323 | 1258 | 1258.0 | 49.1 | 49.1 | The angular gyrus: multiple functions and multiple subdivisions. | Mohamed L Seghier | Neuroscientist | 2013 | 22547530 | No |
| 3324 | 2515 | 1257.5 | 93.6 | 46.8 | The stunned myocardium: prolonged, postischemic ventricular dysfunction. | E Braunwald, R A Kloner | Circulation | 1982 | 6754130 | No |
| 3325 | 2514 | 1257.0 | 68.7 | 34.4 | Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. | M A Pfeffer, E Braunwald | Circulation | 1990 | 2138525 | No |
| 3326 | 1257 | 1257.0 | 80.0 | 80.0 | Root canal anatomy of the human permanent teeth. | F J Vertucci | Oral Surg Oral Med Oral Pathol | 1984 | 6595621 | Yes |
| 3327 | 1257 | 1257.0 | 64.9 | 64.9 | Rating scales to assess depression in school-aged children. | M Kovacs | Acta Paedopsychiatr | 1981 | 7025571 | Yes |
| 3328 | 1257 | 1257.0 | 49.8 | 49.8 | Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. | S H Safe | Crit Rev Toxicol | 1994 | 8037844 | No |
| 3329 | 2514 | 1257.0 | 68.0 | 34.0 | Statistical tests of neutrality of mutations. | Y X Fu, W H Li | Genetics | 1993 | 8454210 | Yes |
| 3330 | 1257 | 1257.0 | 33.4 | 33.4 | Polymer conjugates as anticancer nanomedicines. | Ruth Duncan | Nat Rev Cancer | 2006 | 16900224 | No |
| 3331 | 1257 | 1257.0 | 32.8 | 32.8 | Physiology and pathophysiology of purinergic neurotransmission. | Geoffrey Burnstock | Physiol Rev | 2007 | 17429044 | No |
| 3332 | 2513 | 1256.5 | 52.1 | 26.1 | Molecular chaperones in the cytosol: from nascent chain to folded protein. | F Ulrich Hartl, Manajit Hayer-Hartl | Science | 2002 | 11884745 | No |
| 3333 | 1256 | 1256.0 | 20.7 | 20.7 | The concept of immunological surveillance. | F M Burnet | Prog Exp Tumor Res | 1970 | 4921480 | No |
| 3334 | 1256 | 1256.0 | 26.2 | 26.2 | SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. | S V Evans | J Mol Graph | 1993 | 8347566 | Yes |
| 3335 | 1256 | 1256.0 | 32.9 | 32.9 | Apoptosis. | J J Cohen | Immunol Today | 1993 | 8466628 | No |
| 3336 | 1256 | 1256.0 | 32.2 | 32.2 | Optogenetics. | Karl Deisseroth | Nat Methods | 2011 | 21191368 | Yes |
| 3337 | 2511 | 1255.5 | 105.5 | 52.8 | Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. | T J Cole, T Lobstein | Pediatr Obes | 2012 | 22715120 | Yes |
| 3338 | 6277 | 1255.4 | 257.4 | 51.5 | KEGG: new perspectives on genomes, pathways, diseases and drugs. | Minoru Kanehisa, Miho Furumichi, Mao Tanabe, Yoko Sato, Kanae Morishima | Nucleic Acids Res | 2017 | 27899662 | Yes |
| 3339 | 3766 | 1255.3 | 154.8 | 51.6 | Rheumatoid arthritis. | Josef S Smolen, Daniel Aletaha, Iain B McInnes | Lancet | 2016 | 27156434 | No |
| 3340 | 2510 | 1255.0 | 49.6 | 24.8 | Checkpoints: controls that ensure the order of cell cycle events. | L H Hartwell, T A Weinert | Science | 1989 | 2683079 | No |
| 3341 | 1255 | 1255.0 | 64.7 | 64.7 | The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. | G A Ilizarov | Clin Orthop Relat Res | 1989 | 2910611 | Yes |
| 3342 | 1255 | 1255.0 | 22.2 | 22.2 | Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. | P Rakic | J Comp Neurol | 1971 | 4101340 | Yes |
| 3343 | 1255 | 1255.0 | 40.7 | 40.7 | Strategy and tactics in protein chemistry. | B S Hartley | Biochem J | 1970 | 4923920 | No |
| 3344 | 1255 | 1255.0 | 39.1 | 39.1 | Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. | R Lotan | Biochim Biophys Acta | 1980 | 6989400 | No |
| 3345 | 2510 | 1255.0 | 60.0 | 30.0 | The host defense of Drosophila melanogaster. | Bruno Lemaitre, Jules Hoffmann | Annu Rev Immunol | 2007 | 17201680 | No |
| 3346 | 1255 | 1255.0 | 34.5 | 34.5 | The quantum internet. | H J Kimble | Nature | 2008 | 18563153 | Yes |
| 3347 | 1254 | 1254.0 | 22.5 | 22.5 | NFAT proteins: key regulators of T-cell development and function. | Fernando MacIan | Nat Rev Immunol | 2005 | 15928679 | No |
| 3348 | 2507 | 1253.5 | 60.0 | 30.0 | DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1987 | 3474623 | Yes |
| 3349 | 1253 | 1253.0 | 42.2 | 42.2 | The structure of common mental disorders. | R F Krueger | Arch Gen Psychiatry | 1999 | 10530634 | Yes |
| 3350 | 1253 | 1253.0 | 33.4 | 33.4 | Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. | R Zahorec | Bratisl Lek Listy | 2001 | 11723675 | Yes |
| 3351 | 3759 | 1253.0 | 77.3 | 25.8 | SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. | Jay D Horton, Joseph L Goldstein, Michael S Brown | J Clin Invest | 2002 | 11994399 | No |
| 3352 | 1253 | 1253.0 | 28.5 | 28.5 | Lithium batteries and cathode materials. | M Stanley Whittingham | Chem Rev | 2004 | 15669156 | Yes |
| 3353 | 1253 | 1253.0 | 29.8 | 29.8 | Matrix eQTL: ultra fast eQTL analysis via large matrix operations. | Andrey A Shabalin | Bioinformatics | 2012 | 22492648 | Yes |
| 3354 | 1253 | 1253.0 | 50.4 | 50.4 | Vitamin D metabolism, mechanism of action, and clinical applications. | Daniel D Bikle | Chem Biol | 2014 | 24529992 | No |
| 3355 | 1253 | 1253.0 | 57.9 | 57.9 | Using Bayes to get the most out of non-significant results. | Zoltan Dienes | Front Psychol | 2014 | 25120503 | Yes |
| 3356 | 6264 | 1252.8 | 296.4 | 59.3 | VSEARCH: a versatile open source tool for metagenomics. | Torbjorn Rognes, Tomas Flouri, Ben Nichols, Christopher Quince, Frederic Mahe | PeerJ | 2016 | 27781170 | Yes |
| 3357 | 2505 | 1252.5 | 142.8 | 71.4 | The Neck Disability Index: a study of reliability and validity. | H Vernon, S Mior | J Manipulative Physiol Ther | 1991 | 1834753 | Yes |
| 3358 | 2505 | 1252.5 | 65.0 | 32.5 | Interaction revisited: the difference between two estimates. | Douglas G Altman, J Martin Bland | BMJ | 2003 | 12543843 | No |
| 3359 | 2505 | 1252.5 | 106.0 | 53.0 | The Tumor Microenvironment Innately Modulates Cancer Progression. | Dominique C Hinshaw, Lalita A Shevde | Cancer Res | 2019 | 31350295 | No |
| 3360 | 5009 | 1252.2 | 230.5 | 57.6 | An ecological perspective on health promotion programs. | K R McLeroy, D Bibeau, A Steckler, K Glanz | Health Educ Q | 1988 | 3068205 | No |
| 3361 | 2503 | 1251.5 | 90.6 | 45.3 | ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap. | Tauno Metsalu, Jaak Vilo | Nucleic Acids Res | 2015 | 25969447 | Yes |
| 3362 | 1251 | 1251.0 | 37.7 | 37.7 | Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. | J C Morris | Int Psychogeriatr | 1997 | 9447441 | Yes |
| 3363 | 1251 | 1251.0 | 35.3 | 35.3 | Abiotic stress, the field environment and stress combination. | Ron Mittler | Trends Plant Sci | 2006 | 16359910 | No |
| 3364 | 2502 | 1251.0 | 63.5 | 31.8 | The regulation of IL-10 production by immune cells. | Margarida Saraiva, Anne O'Garra | Nat Rev Immunol | 2010 | 20154735 | No |
| 3365 | 2501 | 1250.5 | 85.6 | 42.8 | The gut microbiota--masters of host development and physiology. | Felix Sommer, Fredrik Backhed | Nat Rev Microbiol | 2013 | 23435359 | No |
| 3366 | 2500 | 1250.0 | 75.2 | 37.6 | Mechanisms of biofilm resistance to antimicrobial agents. | T F Mah, G A O'Toole | Trends Microbiol | 2001 | 11166241 | No |
| 3367 | 2498 | 1249.0 | 65.7 | 32.9 | Genetic dissection of complex traits. | E S Lander, N J Schork | Science | 1994 | 8091226 | No |
| 3368 | 2498 | 1249.0 | 86.5 | 43.2 | Long Noncoding RNAs in Cancer Pathways. | Adam M Schmitt, Howard Y Chang | Cancer Cell | 2016 | 27070700 | No |
| 3369 | 2497 | 1248.5 | 100.4 | 50.2 | Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. | I B Wilson, P D Cleary | JAMA | 1995 | 7996652 | Yes |
| 3370 | 3745 | 1248.3 | 174.6 | 58.2 | Relatives of the impaired elderly: correlates of feelings of burden. | S H Zarit, K E Reever, J Bach-Peterson | Gerontologist | 1980 | 7203086 | Yes |
| 3371 | 1248 | 1248.0 | 35.8 | 35.8 | Structure and function of intercellular junctions. | L A Staehelin | Int Rev Cytol | 1974 | 4611943 | No |
| 3372 | 6240 | 1248.0 | 232.1 | 46.4 | Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. | Jonathan D Power, Kelly A Barnes, Abraham Z Snyder, Bradley L Schlaggar, Steven E Petersen | Neuroimage | 2012 | 22019881 | Yes |
| 3373 | 2496 | 1248.0 | 97.0 | 48.5 | OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy. | David M Emms, Steven Kelly | Genome Biol | 2015 | 26243257 | Yes |
| 3374 | 2495 | 1247.5 | 98.1 | 49.0 | Societal and individual determinants of medical care utilization in the United States. | R Andersen, J F Newman | Milbank Mem Fund Q Health Soc | 1973 | 4198894 | Yes |
| 3375 | 2495 | 1247.5 | 118.2 | 59.1 | Neurobiology of addiction: a neurocircuitry analysis. | George F Koob, Nora D Volkow | Lancet Psychiatry | 2016 | 27475769 | No |
| 3376 | 6237 | 1247.4 | 227.4 | 45.5 | Posttraumatic stress disorder in the National Comorbidity Survey. | R C Kessler, A Sonnega, E Bromet, M Hughes, C B Nelson | Arch Gen Psychiatry | 1995 | 7492257 | Yes |
| 3377 | 2494 | 1247.0 | 71.7 | 35.9 | Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. | R G Phillips, J E LeDoux | Behav Neurosci | 1992 | 1590953 | Yes |
| 3378 | 1247 | 1247.0 | 20.9 | 20.9 | Antigen receptor tail clue. | M Reth | Nature | 1989 | 2927501 | Yes |
| 3379 | 1247 | 1247.0 | 0.0 | 0.0 | Sequential tests for the detection of linkage. | N E Morton | Am J Hum Genet | 1955 | 13258560 | Yes |
| 3380 | 3739 | 1246.3 | 148.9 | 49.6 | Neighborhoods and violent crime: a multilevel study of collective efficacy. | R J Sampson, S W Raudenbush, F Earls | Science | 1997 | 9252316 | Yes |
| 3381 | 3739 | 1246.3 | 190.7 | 63.6 | Content analysis and thematic analysis: Implications for conducting a qualitative descriptive study. | Mojtaba Vaismoradi, Hannele Turunen, Terese Bondas | Nurs Health Sci | 2013 | 23480423 | No |
| 3382 | 1246 | 1246.0 | 31.9 | 31.9 | Two-stage model of memory trace formation: a role for "noisy" brain states. | G Buzsaki | Neuroscience | 1989 | 2687720 | No |
| 3383 | 1246 | 1246.0 | 40.5 | 40.5 | Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. | M E Bouton | Psychol Bull | 1993 | 8346330 | No |
| 3384 | 2492 | 1246.0 | 77.1 | 38.5 | Natural products as sources of new drugs over the last 25 years. | David J Newman, Gordon M Cragg | J Nat Prod | 2007 | 17309302 | No |
| 3385 | 1246 | 1246.0 | 47.9 | 47.9 | What Good Are Positive Emotions? | Barbara L Fredrickson | Rev Gen Psychol | 1998 | 21850154 | Yes |
| 3386 | 3737 | 1245.7 | 129.1 | 43.0 | Stimuli-responsive nanocarriers for drug delivery. | Simona Mura, Julien Nicolas, Patrick Couvreur | Nat Mater | 2013 | 24150417 | No |
| 3387 | 1245 | 1245.0 | 76.0 | 76.0 | The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement. | M M Panjabi | J Spinal Disord | 1992 | 1490034 | Yes |
| 3388 | 1245 | 1245.0 | 28.2 | 28.2 | Life, death, and the pursuit of apoptosis. | E White | Genes Dev | 1996 | 8557188 | No |
| 3389 | 1245 | 1245.0 | 33.2 | 33.2 | Mode of action of membrane active antimicrobial peptides. | Yechiel Shai | Biopolymers | 2002 | 12491537 | No |
| 3390 | 1245 | 1245.0 | 48.3 | 48.3 | Odorant reception in insects: roles of receptors, binding proteins, and degrading enzymes. | Walter S Leal | Annu Rev Entomol | 2013 | 23020622 | No |
| 3391 | 7469 | 1244.8 | 145.0 | 24.2 | Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. | S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T Tuschl | Nature | 2001 | 11373684 | Yes |
| 3392 | 3734 | 1244.7 | 111.6 | 37.2 | A sensitive and reliable locomotor rating scale for open field testing in rats. | D M Basso, M S Beattie, J C Bresnahan | J Neurotrauma | 1995 | 7783230 | Yes |
| 3393 | 3734 | 1244.7 | 135.7 | 45.2 | Social relationships and mortality risk: a meta-analytic review. | Julianne Holt-Lunstad, Timothy B Smith, J Bradley Layton | PLoS Med | 2010 | 20668659 | No |
| 3394 | 2489 | 1244.5 | 63.6 | 31.8 | Molecular mechanisms of action of steroid/thyroid receptor superfamily members. | M J Tsai, B W O'Malley | Annu Rev Biochem | 1994 | 7979245 | No |
| 3395 | 1244 | 1244.0 | 22.4 | 22.4 | Stem cells: units of development, units of regeneration, and units in evolution. | I L Weissman | Cell | 2000 | 10647940 | No |
| 3396 | 1244 | 1244.0 | 32.2 | 32.2 | Overview of the immune response. | David D Chaplin | J Allergy Clin Immunol | 2010 | 20176265 | No |
| 3397 | 2488 | 1244.0 | 126.6 | 63.3 | Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis. | Laura M Doyle, Michael Zhuo Wang | Cells | 2019 | 31311206 | No |
| 3398 | 2488 | 1244.0 | 192.3 | 96.2 | Mental Health and the Covid-19 Pandemic. | Betty Pfefferbaum, Carol S North | N Engl J Med | 2020 | 32283003 | Yes |
| 3399 | 1243 | 1243.0 | 36.4 | 36.4 | The neurobiology of stress: from serendipity to clinical relevance. | B S McEwen | Brain Res | 2000 | 11119695 | No |
| 3400 | 2486 | 1243.0 | 52.8 | 26.4 | The mammalian unfolded protein response. | Martin Schroder, Randal J Kaufman | Annu Rev Biochem | 2005 | 15952902 | No |
| 3401 | 3729 | 1243.0 | 85.0 | 28.3 | Population structure and eigenanalysis. | Nick Patterson, Alkes L Price, David Reich | PLoS Genet | 2006 | 17194218 | Yes |
| 3402 | 2484 | 1242.0 | 54.7 | 27.4 | Atherosclerosis. the road ahead. | C K Glass, J L Witztum | Cell | 2001 | 11239408 | No |
| 3403 | 1242 | 1242.0 | 25.4 | 25.4 | Liver regeneration: from myth to mechanism. | Rebecca Taub | Nat Rev Mol Cell Biol | 2004 | 15459664 | No |
| 3404 | 2484 | 1242.0 | 55.9 | 27.9 | Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. | Jing Yang, Robert A Weinberg | Dev Cell | 2008 | 18539112 | No |
| 3405 | 2483 | 1241.5 | 55.9 | 27.9 | Finding and evaluating community structure in networks. | M E J Newman, M Girvan | Phys Rev E Stat Nonlin Soft Matter Phys | 2004 | 14995526 | Yes |
| 3406 | 2483 | 1241.5 | 78.1 | 39.0 | Health effects of fine particulate air pollution: lines that connect. | C Arden Pope, Douglas W Dockery | J Air Waste Manag Assoc | 2006 | 16805397 | No |
| 3407 | 3724 | 1241.3 | 122.9 | 41.0 | Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. | Irith Wiegand, Kai Hilpert, Robert E W Hancock | Nat Protoc | 2008 | 18274517 | Yes |
| 3408 | 1241 | 1241.0 | 60.1 | 60.1 | Continuous improvement as an ideal in health care. | D M Berwick | N Engl J Med | 1989 | 2909878 | Yes |
| 3409 | 1241 | 1241.0 | 0.0 | 0.0 | Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. | J M Van Rossum | Arch Int Pharmacodyn Ther | 1963 | 13996119 | Yes |
| 3410 | 2482 | 1241.0 | 67.6 | 33.8 | Localized surface plasmon resonance spectroscopy and sensing. | Katherine A Willets, Richard P Van Duyne | Annu Rev Phys Chem | 2007 | 17067281 | No |
| 3411 | 1241 | 1241.0 | 44.6 | 44.6 | T Follicular Helper Cell Biology: A Decade of Discovery and Diseases. | Shane Crotty | Immunity | 2019 | 31117010 | No |
| 3412 | 6203 | 1240.6 | 255.8 | 51.2 | MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph. | Dinghua Li, Chi-Man Liu, Ruibang Luo, Kunihiko Sadakane, Tak-Wah Lam | Bioinformatics | 2015 | 25609793 | Yes |
| 3413 | 2479 | 1239.5 | 111.5 | 55.8 | Problems and proposals for recording gingivitis and plaque. | J Ainamo, I Bay | Int Dent J | 1975 | 1058834 | Yes |
| 3414 | 2479 | 1239.5 | 84.1 | 42.0 | Superoxide dismutases: I. Occurrence in higher plants. | C N Giannopolitis, S K Ries | Plant Physiol | 1977 | 16659839 | Yes |
| 3415 | 4958 | 1239.5 | 136.2 | 34.0 | Gene ontology analysis for RNA-seq: accounting for selection bias. | Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia Oshlack | Genome Biol | 2010 | 20132535 | Yes |
| 3416 | 1239 | 1239.0 | 38.2 | 38.2 | Riddle of biofilm resistance. | K Lewis | Antimicrob Agents Chemother | 2001 | 11257008 | No |
| 3417 | 2478 | 1239.0 | 0.0 | 0.0 | The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. | B N Ames, D T Dubin | J Biol Chem | 1960 | 13793161 | Yes |
| 3418 | 1239 | 1239.0 | 24.5 | 24.5 | Lipid rafts: elusive or illusive? | Sean Munro | Cell | 2003 | 14622593 | No |
| 3419 | 1239 | 1239.0 | 47.6 | 47.6 | The pain self-efficacy questionnaire: Taking pain into account. | Michael K Nicholas | Eur J Pain | 2007 | 16446108 | Yes |
| 3420 | 1239 | 1239.0 | 24.7 | 24.7 | Models, mechanisms and clinical evidence for cancer dormancy. | Julio A Aguirre-Ghiso | Nat Rev Cancer | 2007 | 17957189 | No |
| 3421 | 1239 | 1239.0 | 48.4 | 48.4 | Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). | F Berenbaum | Osteoarthritis Cartilage | 2013 | 23194896 | No |
| 3422 | 6194 | 1238.8 | 200.3 | 40.1 | Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. | J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman | Proc Natl Acad Sci U S A | 1990 | 2154753 | Yes |
| 3423 | 2477 | 1238.5 | 56.4 | 28.2 | Toll-like receptors in innate immunity. | Kiyoshi Takeda, Shizuo Akira | Int Immunol | 2005 | 15585605 | No |
| 3424 | 1238 | 1238.0 | 42.6 | 42.6 | How is the level of free arachidonic acid controlled in mammalian cells? | R F Irvine | Biochem J | 1982 | 6810878 | No |
| 3425 | 1238 | 1238.0 | 37.5 | 37.5 | Papillary and follicular thyroid carcinoma. | M J Schlumberger | N Engl J Med | 1998 | 9445411 | No |
| 3426 | 1238 | 1238.0 | 35.7 | 35.7 | Cholinesterase inhibitors for Alzheimer's disease. | J Birks | Cochrane Database Syst Rev | 2006 | 16437532 | Yes |
| 3427 | 2475 | 1237.5 | 73.4 | 36.7 | Imaging cognition II: An empirical review of 275 PET and fMRI studies. | R Cabeza, L Nyberg | J Cogn Neurosci | 2000 | 10769304 | No |
| 3428 | 2474 | 1237.0 | 56.5 | 28.2 | Adaptive protein evolution at the Adh locus in Drosophila. | J H McDonald, M Kreitman | Nature | 1991 | 1904993 | Yes |
| 3429 | 2474 | 1237.0 | 39.9 | 19.9 | A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. | D Tautz, C Pfeifle | Chromosoma | 1989 | 2476281 | Yes |
| 3430 | 1237 | 1237.0 | 37.7 | 37.7 | Calcium channel modulation by neurotransmitters, enzymes and drugs. | H Reuter | Nature | 1983 | 6131381 | No |
| 3431 | 1237 | 1237.0 | 44.9 | 44.9 | Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators. | B A Hess | Phys Rev A Gen Phys | 1986 | 9897114 | Yes |
| 3432 | 2474 | 1237.0 | 71.8 | 35.9 | Fitness effects on the cognitive function of older adults: a meta-analytic study. | Stanley Colcombe, Arthur F Kramer | Psychol Sci | 2003 | 12661673 | Yes |
| 3433 | 1237 | 1237.0 | 0.0 | 0.0 | A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. | M G Buonocore | J Dent Res | 1955 | 13271655 | Yes |
| 3434 | 1237 | 1237.0 | 30.6 | 30.6 | Ab-initio simulations of materials using VASP: Density-functional theory and beyond. | Jurgen Hafner | J Comput Chem | 2008 | 18623101 | Yes |
| 3435 | 3709 | 1236.3 | 139.5 | 46.5 | Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. | Michael A Postow, Robert Sidlow, Matthew D Hellmann | N Engl J Med | 2018 | 29320654 | No |
| 3436 | 1236 | 1236.0 | 29.0 | 29.0 | The columnar organization of the neocortex. | V B Mountcastle | Brain | 1997 | 9153131 | No |
| 3437 | 1236 | 1236.0 | 29.9 | 29.9 | Mitochondrial transport of cations: channels, exchangers, and permeability transition. | P Bernardi | Physiol Rev | 1999 | 10508231 | No |
| 3438 | 1236 | 1236.0 | 26.9 | 26.9 | Apoptosis in neurodegenerative disorders. | M P Mattson | Nat Rev Mol Cell Biol | 2000 | 11253364 | No |
| 3439 | 2472 | 1236.0 | 76.3 | 38.1 | Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. | S Geman, D Geman | IEEE Trans Pattern Anal Mach Intell | 1984 | 22499653 | Yes |
| 3440 | 1236 | 1236.0 | 35.2 | 35.2 | Cyclin-dependent kinases. | Marcos Malumbres | Genome Biol | 2014 | 25180339 | No |
| 3441 | 1236 | 1236.0 | 66.2 | 66.2 | Cisplatin: The first metal based anticancer drug. | Sumit Ghosh | Bioorg Chem | 2019 | 31003078 | No |
| 3442 | 3706 | 1235.3 | 87.5 | 29.2 | Obesity induces a phenotypic switch in adipose tissue macrophage polarization. | Carey N Lumeng, Jennifer L Bodzin, Alan R Saltiel | J Clin Invest | 2007 | 17200717 | Yes |
| 3443 | 13587 | 1235.2 | 470.5 | 42.8 | A global reference for human genetic variation. | , Adam Auton, Lisa D Brooks, Richard M Durbin, Erik P Garrison, Hyun Min Kang, Jan O Korbel, Jonathan L Marchini, Shane McCarthy, Gil A McVean, Goncalo R Abecasis | Nature | 2015 | 26432245 | Yes |
| 3444 | 1235 | 1235.0 | 29.0 | 29.0 | Translating cell biology into therapeutic advances in Alzheimer's disease. | D J Selkoe | Nature | 1999 | 10392577 | No |
| 3445 | 1235 | 1235.0 | 34.2 | 34.2 | Neural stimulation and recording electrodes. | Stuart F Cogan | Annu Rev Biomed Eng | 2008 | 18429704 | No |
| 3446 | 1235 | 1235.0 | 37.3 | 37.3 | Periodontitis: a polymicrobial disruption of host homeostasis. | Richard P Darveau | Nat Rev Microbiol | 2010 | 20514045 | No |
| 3447 | 1235 | 1235.0 | 39.4 | 39.4 | The Danish Cancer Registry. | Marianne Lundkjaer Gjerstorff | Scand J Public Health | 2011 | 21775350 | Yes |
| 3448 | 1235 | 1235.0 | 80.8 | 80.8 | Confirmatory factor analysis with ordinal data: Comparing robust maximum likelihood and diagonally weighted least squares. | Cheng-Hsien Li | Behav Res Methods | 2016 | 26174714 | Yes |
| 3449 | 3704 | 1234.7 | 118.0 | 39.3 | Hepatocellular carcinoma. | Alejandro Forner, Josep M Llovet, Jordi Bruix | Lancet | 2012 | 22353262 | No |
| 3450 | 2469 | 1234.5 | 618.4 | 309.2 | Interactive Tree of Life (iTOL) v6: recent updates to the phylogenetic tree display and annotation tool. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2024 | 38613393 | Yes |
| 3451 | 1234 | 1234.0 | 0.0 | 0.0 | Voluntary strength and fatigue. | P A Merton | J Physiol | 1954 | 13152698 | Yes |
| 3452 | 3702 | 1234.0 | 102.1 | 34.0 | Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. | Robert G Hart, Lesly A Pearce, Maria I Aguilar | Ann Intern Med | 2007 | 17577005 | Yes |
| 3453 | 2466 | 1233.0 | 75.1 | 37.5 | Reactive oxygen species, cellular redox systems, and apoptosis. | Magdalena L Circu, Tak Yee Aw | Free Radic Biol Med | 2010 | 20045723 | No |
| 3454 | 1232 | 1232.0 | 67.4 | 67.4 | A "rationalized" arcsine transform. | G A Studebaker | J Speech Hear Res | 1985 | 4046587 | Yes |
| 3455 | 1232 | 1232.0 | 27.1 | 27.1 | Caspase structure, proteolytic substrates, and function during apoptotic cell death. | D W Nicholson | Cell Death Differ | 1999 | 10578171 | No |
| 3456 | 1232 | 1232.0 | 34.4 | 34.4 | Principles of c-di-GMP signalling in bacteria. | Regine Hengge | Nat Rev Microbiol | 2009 | 19287449 | No |
| 3457 | 1231 | 1231.0 | 123.0 | 123.0 | The analysis of errors in orthodontic measurements. | W J Houston | Am J Orthod | 1983 | 6573846 | Yes |
| 3458 | 2462 | 1231.0 | 53.8 | 26.9 | The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. | A Bairoch, R Apweiler | Nucleic Acids Res | 2000 | 10592178 | Yes |
| 3459 | 1231 | 1231.0 | 25.5 | 25.5 | Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. | Harold F Dvorak | J Clin Oncol | 2002 | 12409337 | No |
| 3460 | 1231 | 1231.0 | 48.0 | 48.0 | A polarizing question: do M1 and M2 microglia exist? | Richard M Ransohoff | Nat Neurosci | 2016 | 27459405 | No |
| 3461 | 4923 | 1230.8 | 135.9 | 34.0 | Mussel-inspired surface chemistry for multifunctional coatings. | Haeshin Lee, Shara M Dellatore, William M Miller, Phillip B Messersmith | Science | 2007 | 17947576 | Yes |
| 3462 | 1230 | 1230.0 | 60.9 | 60.9 | ROC methodology in radiologic imaging. | C E Metz | Invest Radiol | 1986 | 3095258 | No |
| 3463 | 1230 | 1230.0 | 39.5 | 39.5 | Relations between the statistics of natural images and the response properties of cortical cells. | D J Field | J Opt Soc Am A | 1987 | 3430225 | Yes |
| 3464 | 4920 | 1230.0 | 141.8 | 35.5 | Place navigation impaired in rats with hippocampal lesions. | R G Morris, P Garrud, J N Rawlins, J O'Keefe | Nature | 1982 | 7088155 | Yes |
| 3465 | 1230 | 1230.0 | 24.7 | 24.7 | STATs: signal transducers and activators of transcription. | J N Ihle | Cell | 1996 | 8608586 | No |
| 3466 | 1230 | 1230.0 | 51.2 | 51.2 | Measures of anxiety: State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). | Laura J Julian | Arthritis Care Res (Hoboken) | 2011 | 22588767 | No |
| 3467 | 1230 | 1230.0 | 50.0 | 50.0 | Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. | Peter J Barnes | J Allergy Clin Immunol | 2016 | 27373322 | No |
| 3468 | 2459 | 1229.5 | 76.0 | 38.0 | Recent advances in the phencyclidine model of schizophrenia. | D C Javitt, S R Zukin | Am J Psychiatry | 1991 | 1654746 | No |
| 3469 | 2459 | 1229.5 | 56.4 | 28.2 | microRNA functions. | Natascha Bushati, Stephen M Cohen | Annu Rev Cell Dev Biol | 2007 | 17506695 | No |
| 3470 | 1229 | 1229.0 | 35.3 | 35.3 | Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. | F Hefti | J Neurosci | 1986 | 3746405 | Yes |
| 3471 | 1229 | 1229.0 | 63.1 | 63.1 | Osseointegration and its experimental background. | P I Branemark | J Prosthet Dent | 1983 | 6352924 | No |
| 3472 | 1229 | 1229.0 | 26.0 | 26.0 | Morphogenetic roles of classic cadherins. | M Takeichi | Curr Opin Cell Biol | 1995 | 8573335 | No |
| 3473 | 1229 | 1229.0 | 54.5 | 54.5 | Beyond curriculum reform: confronting medicine's hidden curriculum. | F W Hafferty | Acad Med | 1998 | 9580717 | Yes |
| 3474 | 2458 | 1229.0 | 58.5 | 29.2 | Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. | N Sreerama, R W Woody | Anal Biochem | 2000 | 11112271 | Yes |
| 3475 | 1229 | 1229.0 | 33.9 | 33.9 | Inflammation 2010: new adventures of an old flame. | Ruslan Medzhitov | Cell | 2010 | 20303867 | No |
| 3476 | 1229 | 1229.0 | 65.7 | 65.7 | Resin composite--state of the art. | Jack L Ferracane | Dent Mater | 2011 | 21093034 | No |
| 3477 | 1229 | 1229.0 | 35.7 | 35.7 | Cellular and molecular mechanisms of renal fibrosis. | Youhua Liu | Nat Rev Nephrol | 2011 | 22009250 | No |
| 3478 | 2457 | 1228.5 | 53.5 | 26.8 | Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. | G K McMaster, G G Carmichael | Proc Natl Acad Sci U S A | 1977 | 73185 | Yes |
| 3479 | 2457 | 1228.5 | 89.7 | 44.9 | The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. | G P Chrousos, P W Gold | JAMA | 1992 | 1538563 | No |
| 3480 | 1228 | 1228.0 | 27.6 | 27.6 | The epidemiologic transition. A theory of the epidemiology of population change. | A R Omran | Milbank Mem Fund Q | 1971 | 5155251 | Yes |
| 3481 | 1228 | 1228.0 | 39.1 | 39.1 | On the utility of P3 amplitude as a measure of processing capacity. | A Kok | Psychophysiology | 2001 | 11352145 | No |
| 3482 | 1228 | 1228.0 | 39.0 | 39.0 | On the mechanisms of biocompatibility. | David F Williams | Biomaterials | 2008 | 18440630 | No |
| 3483 | 2454 | 1227.0 | 107.5 | 53.8 | Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. | L A Clark, D Watson | J Abnorm Psychol | 1991 | 1918611 | No |
| 3484 | 1227 | 1227.0 | 27.2 | 27.2 | Twilight zone of protein sequence alignments. | B Rost | Protein Eng | 1999 | 10195279 | Yes |
| 3485 | 1227 | 1227.0 | 32.5 | 32.5 | Seed Germination and Dormancy. | J D Bewley | Plant Cell | 1997 | 12237375 | Yes |
| 3486 | 2454 | 1227.0 | 49.4 | 24.7 | Tumour-cell invasion and migration: diversity and escape mechanisms. | Peter Friedl, Katarina Wolf | Nat Rev Cancer | 2003 | 12724734 | No |
| 3487 | 1227 | 1227.0 | 27.4 | 27.4 | Next-generation DNA sequencing methods. | Elaine R Mardis | Annu Rev Genomics Hum Genet | 2008 | 18576944 | No |
| 3488 | 3680 | 1226.7 | 129.2 | 43.1 | The MaxQuant computational platform for mass spectrometry-based shotgun proteomics. | Stefka Tyanova, Tikira Temu, Juergen Cox | Nat Protoc | 2016 | 27809316 | Yes |
| 3489 | 2453 | 1226.5 | 63.0 | 31.5 | Quorum sensing: cell-to-cell communication in bacteria. | Christopher M Waters, Bonnie L Bassler | Annu Rev Cell Dev Biol | 2005 | 16212498 | No |
| 3490 | 3679 | 1226.3 | 114.0 | 38.0 | Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. | H King, R E Aubert, W H Herman | Diabetes Care | 1998 | 9727886 | Yes |
| 3491 | 2452 | 1226.0 | 100.3 | 50.1 | A real-time QRS detection algorithm. | J Pan, W J Tompkins | IEEE Trans Biomed Eng | 1985 | 3997178 | Yes |
| 3492 | 1226 | 1226.0 | 35.0 | 35.0 | Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. | P O Seglen | Exp Cell Res | 1973 | 4358115 | Yes |
| 3493 | 1226 | 1226.0 | 36.3 | 36.3 | The mechanisms of alloxan- and streptozotocin-induced diabetes. | S Lenzen | Diabetologia | 2008 | 18087688 | No |
| 3494 | 1226 | 1226.0 | 34.2 | 34.2 | Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. | Gregg L Semenza | Trends Pharmacol Sci | 2012 | 22398146 | No |
| 3495 | 3678 | 1226.0 | 109.7 | 36.6 | Macrophage biology in development, homeostasis and disease. | Thomas A Wynn, Ajay Chawla, Jeffrey W Pollard | Nature | 2013 | 23619691 | No |
| 3496 | 1226 | 1226.0 | 41.9 | 41.9 | The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments. | Peter C Austin | Stat Med | 2014 | 24122911 | Yes |
| 3497 | 1225 | 1225.0 | 29.5 | 29.5 | Growth factors and cancer. | S A Aaronson | Science | 1991 | 1659742 | No |
| 3498 | 1224 | 1224.0 | 22.4 | 22.4 | Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. | H E Ruley | Nature | 1983 | 6308473 | Yes |
| 3499 | 1224 | 1224.0 | 25.9 | 25.9 | Intracellular protein topogenesis. | G Blobel | Proc Natl Acad Sci U S A | 1980 | 6929499 | Yes |
| 3500 | 1224 | 1224.0 | 28.2 | 28.2 | Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. | T A Springer | Annu Rev Physiol | 1995 | 7778885 | No |
| 3501 | 2448 | 1224.0 | 100.3 | 50.1 | Shared decision making--pinnacle of patient-centered care. | Michael J Barry, Susan Edgman-Levitan | N Engl J Med | 2012 | 22375967 | Yes |
| 3502 | 2447 | 1223.5 | 79.1 | 39.5 | Photoacoustic tomography: in vivo imaging from organelles to organs. | Lihong V Wang, Song Hu | Science | 2012 | 22442475 | No |
| 3503 | 2447 | 1223.5 | 92.6 | 46.3 | Ferroptosis: Death by Lipid Peroxidation. | Wan Seok Yang, Brent R Stockwell | Trends Cell Biol | 2016 | 26653790 | No |
| 3504 | 1223 | 1223.0 | 42.6 | 42.6 | The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. | N M Kaplan | Arch Intern Med | 1989 | 2662932 | No |
| 3505 | 2446 | 1223.0 | 110.7 | 55.4 | Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. | P R Hunter, M A Gaston | J Clin Microbiol | 1988 | 3069867 | Yes |
| 3506 | 1223 | 1223.0 | 79.9 | 79.9 | Impingement lesions. | C S Neer | Clin Orthop Relat Res | 1983 | 6825348 | Yes |
| 3507 | 1223 | 1223.0 | 27.6 | 27.6 | Dendritic cells: unique leukocyte populations which control the primary immune response. | D N Hart | Blood | 1997 | 9345009 | No |
| 3508 | 1223 | 1223.0 | 0.0 | 0.0 | Fertilizing capacity of spermatozoa deposited into the fallopian tubes. | M C Chang | Nature | 1951 | 14882325 | Yes |
| 3509 | 1223 | 1223.0 | 33.5 | 33.5 | Neuronal gamma-band synchronization as a fundamental process in cortical computation. | Pascal Fries | Annu Rev Neurosci | 2009 | 19400723 | No |
| 3510 | 2446 | 1223.0 | 66.7 | 33.4 | The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. | Maria M Mihaylova, Reuben J Shaw | Nat Cell Biol | 2011 | 21892142 | No |
| 3511 | 1222 | 1222.0 | 26.8 | 26.8 | Antigen-presenting function of the macrophage. | E R Unanue | Annu Rev Immunol | 1984 | 6242349 | No |
| 3512 | 3666 | 1222.0 | 203.3 | 67.8 | Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG) | P L Hudak, P C Amadio, C Bombardier | Am J Ind Med | 1996 | 8773720 | Yes |
| 3513 | 1222 | 1222.0 | 32.3 | 32.3 | The neuropathology of schizophrenia. A critical review of the data and their interpretation. | P J Harrison | Brain | 1999 | 10219775 | No |
| 3514 | 1222 | 1222.0 | 32.5 | 32.5 | Fibrinogen and fibrin structure and functions. | M W Mosesson | J Thromb Haemost | 2005 | 16102057 | No |
| 3515 | 2444 | 1222.0 | 106.6 | 53.3 | Epidemiology of adult fractures: A review. | Charles M Court-Brown, Ben Caesar | Injury | 2006 | 16814787 | No |
| 3516 | 1222 | 1222.0 | 39.9 | 39.9 | Chronic stress, drug use, and vulnerability to addiction. | Rajita Sinha | Ann N Y Acad Sci | 2008 | 18991954 | No |
| 3517 | 7331 | 1221.8 | 197.2 | 32.9 | Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. | Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins, | Lancet | 2002 | 12493255 | Yes |
| 3518 | 3664 | 1221.3 | 78.5 | 26.2 | Large-scale analysis of the yeast proteome by multidimensional protein identification technology. | M P Washburn, D Wolters, J R Yates | Nat Biotechnol | 2001 | 11231557 | Yes |
| 3519 | 1221 | 1221.0 | 34.4 | 34.4 | What is synergy? | M C Berenbaum | Pharmacol Rev | 1989 | 2692037 | No |
| 3520 | 1221 | 1221.0 | 31.8 | 31.8 | Endothelial-leukocyte adhesion molecules. | M P Bevilacqua | Annu Rev Immunol | 1993 | 8476577 | No |
| 3521 | 1221 | 1221.0 | 24.0 | 24.0 | Regulation of cadherin-mediated adhesion in morphogenesis. | Barry M Gumbiner | Nat Rev Mol Cell Biol | 2005 | 16025097 | No |
| 3522 | 2442 | 1221.0 | 47.4 | 23.7 | Rho GTPases: biochemistry and biology. | Aron B Jaffe, Alan Hall | Annu Rev Cell Dev Biol | 2005 | 16212495 | No |
| 3523 | 1221 | 1221.0 | 46.5 | 46.5 | Autonomic nervous system activity in emotion: a review. | Sylvia D Kreibig | Biol Psychol | 2010 | 20371374 | No |
| 3524 | 2442 | 1221.0 | 62.0 | 31.0 | Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. | Sophia Y Lunt, Matthew G Vander Heiden | Annu Rev Cell Dev Biol | 2011 | 21985671 | No |
| 3525 | 3662 | 1220.7 | 108.5 | 36.2 | AMPK: a nutrient and energy sensor that maintains energy homeostasis. | D Grahame Hardie, Fiona A Ross, Simon A Hawley | Nat Rev Mol Cell Biol | 2012 | 22436748 | No |
| 3526 | 2441 | 1220.5 | 58.2 | 29.1 | Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. | Josep M Llovet, Jordi Bruix | Hepatology | 2003 | 12540794 | Yes |
| 3527 | 2441 | 1220.5 | 72.0 | 36.0 | Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. | Amit Etkin, Tor D Wager | Am J Psychiatry | 2007 | 17898336 | Yes |
| 3528 | 12204 | 1220.4 | 290.4 | 29.0 | Scalable molecular dynamics with NAMD. | James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kale, Klaus Schulten | J Comput Chem | 2005 | 16222654 | Yes |
| 3529 | 3661 | 1220.3 | 62.6 | 20.9 | A system for stable expression of short interfering RNAs in mammalian cells. | Thijn R Brummelkamp, Rene Bernards, Reuven Agami | Science | 2002 | 11910072 | Yes |
| 3530 | 19524 | 1220.2 | 763.4 | 47.7 | SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. | Anton Bankevich, Sergey Nurk, Dmitry Antipov, Alexey A Gurevich, Mikhail Dvorkin, Alexander S Kulikov, Valery M Lesin, Sergey I Nikolenko, Son Pham, Andrey D Prjibelski, Alexey V Pyshkin, Alexander V Sirotkin, Nikolay Vyahhi, Glenn Tesler, Max A Alekseyev, Pavel A Pevzner | J Comput Biol | 2012 | 22506599 | Yes |
| 3531 | 1220 | 1220.0 | 34.2 | 34.2 | The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. | R A Jain | Biomaterials | 2000 | 11055295 | No |
| 3532 | 1220 | 1220.0 | 44.0 | 44.0 | Microbial life in the phyllosphere. | Julia A Vorholt | Nat Rev Microbiol | 2012 | 23154261 | No |
| 3533 | 2439 | 1219.5 | 62.5 | 31.2 | Adipocytokines: mediators linking adipose tissue, inflammation and immunity. | Herbert Tilg, Alexander R Moschen | Nat Rev Immunol | 2006 | 16998510 | No |
| 3534 | 2438 | 1219.0 | 45.5 | 22.8 | Hedgehog signaling in animal development: paradigms and principles. | P W Ingham, A P McMahon | Genes Dev | 2001 | 11731473 | No |
| 3535 | 1219 | 1219.0 | 34.4 | 34.4 | Unequal treatment: confronting racial and ethnic disparities in health care. | Alan Nelson | J Natl Med Assoc | 2002 | 12152921 | No |
| 3536 | 1219 | 1219.0 | 38.5 | 38.5 | Social cognition and the brain: a meta-analysis. | Frank Van Overwalle | Hum Brain Mapp | 2009 | 18381770 | Yes |
| 3537 | 1219 | 1219.0 | 36.5 | 36.5 | Normal bone anatomy and physiology. | Bart Clarke | Clin J Am Soc Nephrol | 2008 | 18988698 | No |
| 3538 | 3657 | 1219.0 | 132.9 | 44.3 | IL-6 in inflammation, immunity, and disease. | Toshio Tanaka, Masashi Narazaki, Tadamitsu Kishimoto | Cold Spring Harb Perspect Biol | 2014 | 25190079 | No |
| 3539 | 1219 | 1219.0 | 247.4 | 247.4 | ChatGPT Utility in Healthcare Education, Research, and Practice: Systematic Review on the Promising Perspectives and Valid Concerns. | Malik Sallam | Healthcare (Basel) | 2023 | 36981544 | No |
| 3540 | 6094 | 1218.8 | 313.3 | 62.7 | UFBoot2: Improving the Ultrafast Bootstrap Approximation. | Diep Thi Hoang, Olga Chernomor, Arndt Von Haeseler, Bui Quang Minh, Le Sy Vinh | Mol Biol Evol | 2018 | 29077904 | Yes |
| 3541 | 3656 | 1218.7 | 123.8 | 41.3 | The Danish National Patient Register. | Elsebeth Lynge, Jakob Lynge Sandegaard, Matejka Rebolj | Scand J Public Health | 2011 | 21775347 | Yes |
| 3542 | 1218 | 1218.0 | 21.3 | 21.3 | Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. | M S Wold | Annu Rev Biochem | 1997 | 9242902 | No |
| 3543 | 2436 | 1218.0 | 0.0 | 0.0 | The Aggregation Of Blood Platelets. | G V Born, M J Cross | J Physiol | 1963 | 14056485 | Yes |
| 3544 | 2436 | 1218.0 | 54.2 | 27.1 | Roles of CHOP/GADD153 in endoplasmic reticulum stress. | S Oyadomari, M Mori | Cell Death Differ | 2004 | 14685163 | No |
| 3545 | 2435 | 1217.5 | 46.6 | 23.3 | The druggable genome. | Andrew L Hopkins, Colin R Groom | Nat Rev Drug Discov | 2002 | 12209152 | No |
| 3546 | 1217 | 1217.0 | 30.3 | 30.3 | Bcl-2 initiates a new category of oncogenes: regulators of cell death. | S J Korsmeyer | Blood | 1992 | 1498330 | No |
| 3547 | 1217 | 1217.0 | 37.4 | 37.4 | The mysteries of lipoprotein(a). | G Utermann | Science | 1989 | 2530631 | No |
| 3548 | 2434 | 1217.0 | 81.7 | 40.9 | Physiological parameters in laboratory animals and humans. | B Davies, T Morris | Pharm Res | 1993 | 8378254 | No |
| 3549 | 3650 | 1216.7 | 95.3 | 31.8 | Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. | C R Woese, O Kandler, M L Wheelis | Proc Natl Acad Sci U S A | 1990 | 2112744 | Yes |
| 3550 | 2433 | 1216.5 | 73.1 | 36.5 | Long non-coding RNAs: new players in cell differentiation and development. | Alessandro Fatica, Irene Bozzoni | Nat Rev Genet | 2014 | 24296535 | No |
| 3551 | 1216 | 1216.0 | 49.8 | 49.8 | Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. | E H Beachey | J Infect Dis | 1981 | 7014727 | No |
| 3552 | 1216 | 1216.0 | 34.6 | 34.6 | Diversity of group types, regulation, and function of phospholipase A2. | E A Dennis | J Biol Chem | 1994 | 8175726 | No |
| 3553 | 1216 | 1216.0 | 32.8 | 32.8 | Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. | G Boden | Diabetes | 1997 | 8971073 | No |
| 3554 | 1216 | 1216.0 | 0.0 | 0.0 | The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. | R E Hope-Simpson | Proc R Soc Med | 1965 | 14267505 | Yes |
| 3555 | 2432 | 1216.0 | 63.2 | 31.6 | Cancer epigenetics: from mechanism to therapy. | Mark A Dawson, Tony Kouzarides | Cell | 2012 | 22770212 | No |
| 3556 | 3647 | 1215.7 | 75.7 | 25.2 | Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. | Juri Rappsilber, Matthias Mann, Yasushi Ishihama | Nat Protoc | 2007 | 17703201 | Yes |
| 3557 | 2430 | 1215.0 | 73.0 | 36.5 | Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. | P Brugada, J Brugada | J Am Coll Cardiol | 1992 | 1309182 | Yes |
| 3558 | 1215 | 1215.0 | 52.9 | 52.9 | A spreading-activation theory of retrieval in sentence production. | G S Dell | Psychol Rev | 1986 | 3749399 | Yes |
| 3559 | 4860 | 1215.0 | 129.5 | 32.4 | Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. | Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod Menon | Proc Natl Acad Sci U S A | 2003 | 12506194 | Yes |
| 3560 | 1215 | 1215.0 | 0.0 | 0.0 | A New Serum Type System In Man--The Lp System. | K Berg | Acta Pathol Microbiol Scand | 1963 | 14064818 | Yes |
| 3561 | 1215 | 1215.0 | 39.6 | 39.6 | Staphylococcus epidermidis--the 'accidental' pathogen. | Michael Otto | Nat Rev Microbiol | 2009 | 19609257 | No |
| 3562 | 1215 | 1215.0 | 40.6 | 40.6 | Epidemiology of heart failure. | Veronique L Roger | Circ Res | 2013 | 23989710 | No |
| 3563 | 1214 | 1214.0 | 52.3 | 52.3 | Campylobacter enteritis: a "new" disease. | M B Skirrow | Br Med J | 1977 | 871765 | Yes |
| 3564 | 2428 | 1214.0 | 58.2 | 29.1 | Obesity and insulin resistance. | B B Kahn, J S Flier | J Clin Invest | 2000 | 10953022 | No |
| 3565 | 1214 | 1214.0 | 42.8 | 42.8 | On the law of effect. | R J Herrnstein | J Exp Anal Behav | 1970 | 16811440 | Yes |
| 3566 | 7283 | 1213.8 | 164.7 | 27.4 | Obesity is associated with macrophage accumulation in adipose tissue. | Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W Ferrante | J Clin Invest | 2003 | 14679176 | Yes |
| 3567 | 3640 | 1213.3 | 135.8 | 45.3 | The weirdest people in the world? | Joseph Henrich, Steven J Heine, Ara Norenzayan | Behav Brain Sci | 2010 | 20550733 | Yes |
| 3568 | 1213 | 1213.0 | 27.8 | 27.8 | The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. | S J Collins | Blood | 1987 | 3311197 | No |
| 3569 | 2426 | 1213.0 | 0.0 | 0.0 | High resolution acrylamide gel electrophoresis of histones. | S Panyim, R Chalkley | Arch Biochem Biophys | 1969 | 5778650 | Yes |
| 3570 | 2426 | 1213.0 | 67.8 | 33.9 | Leukocyte-endothelial adhesion molecules. | T M Carlos, J M Harlan | Blood | 1994 | 7522621 | No |
| 3571 | 2426 | 1213.0 | 43.2 | 21.6 | A synthetic oscillatory network of transcriptional regulators. | M B Elowitz, S Leibler | Nature | 2000 | 10659856 | Yes |
| 3572 | 1213 | 1213.0 | 40.5 | 40.5 | Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. | Jeffrey N Katz | J Bone Joint Surg Am | 2006 | 16595438 | No |
| 3573 | 2425 | 1212.5 | 55.4 | 27.7 | Regeneration beyond the glial scar. | Jerry Silver, Jared H Miller | Nat Rev Neurosci | 2004 | 14735117 | No |
| 3574 | 1212 | 1212.0 | 49.0 | 49.0 | Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. | J T Daugirdas | J Am Soc Nephrol | 1993 | 8305648 | Yes |
| 3575 | 1212 | 1212.0 | 30.0 | 30.0 | Matrix proteoglycans: from molecular design to cellular function. | R V Iozzo | Annu Rev Biochem | 1998 | 9759499 | No |
| 3576 | 1212 | 1212.0 | 28.3 | 28.3 | Structure and signalling in the IL-17 receptor family. | Sarah L Gaffen | Nat Rev Immunol | 2009 | 19575028 | No |
| 3577 | 3634 | 1211.3 | 79.0 | 26.3 | Toll-like receptors: critical proteins linking innate and acquired immunity. | S Akira, K Takeda, T Kaisho | Nat Immunol | 2001 | 11477402 | No |
| 3578 | 3634 | 1211.3 | 100.4 | 33.5 | Fluorine in pharmaceuticals: looking beyond intuition. | Klaus Muller, Christoph Faeh, Francois Diederich | Science | 2007 | 17901324 | No |
| 3579 | 1211 | 1211.0 | 0.0 | 0.0 | 6-Hydroxy-dopamine induced degeneration of central monoamine neurons. | U Ungerstedt | Eur J Pharmacol | 1968 | 5718510 | Yes |
| 3580 | 1211 | 1211.0 | 30.4 | 30.4 | Differential projections of the infralimbic and prelimbic cortex in the rat. | Robert P Vertes | Synapse | 2004 | 14579424 | Yes |
| 3581 | 1211 | 1211.0 | 40.3 | 40.3 | Social support and patient adherence to medical treatment: a meta-analysis. | M Robin DiMatteo | Health Psychol | 2004 | 15008666 | Yes |
| 3582 | 1211 | 1211.0 | 25.4 | 25.4 | Membrane recognition by phospholipid-binding domains. | Mark A Lemmon | Nat Rev Mol Cell Biol | 2008 | 18216767 | No |
| 3583 | 1211 | 1211.0 | 45.0 | 45.0 | Constructive and unconstructive repetitive thought. | Edward R Watkins | Psychol Bull | 2008 | 18298268 | No |
| 3584 | 1211 | 1211.0 | 36.1 | 36.1 | Targeting the DNA Damage Response in Cancer. | Mark J O'Connor | Mol Cell | 2015 | 26590714 | No |
| 3585 | 6054 | 1210.8 | 184.0 | 36.8 | Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. | Carol Kilkenny, William J Browne, Innes C Cuthill, Michael Emerson, Douglas G Altman | PLoS Biol | 2010 | 20613859 | No |
| 3586 | 2421 | 1210.5 | 52.6 | 26.3 | Plant pathogens and integrated defence responses to infection. | J L Dangl, J D Jones | Nature | 2001 | 11459065 | No |
| 3587 | 2421 | 1210.5 | 69.2 | 34.6 | Strategies in the design of nanoparticles for therapeutic applications. | Robby A Petros, Joseph M DeSimone | Nat Rev Drug Discov | 2010 | 20616808 | No |
| 3588 | 7262 | 1210.3 | 264.7 | 44.1 | The occurrence of sleep-disordered breathing among middle-aged adults. | T Young, M Palta, J Dempsey, J Skatrud, S Weber, S Badr | N Engl J Med | 1993 | 8464434 | Yes |
| 3589 | 1210 | 1210.0 | 37.6 | 37.6 | The induction of pain: an integrative review. | M J Millan | Prog Neurobiol | 1999 | 9987804 | No |
| 3590 | 2419 | 1209.5 | 73.0 | 36.5 | Genome-wide efficient mixed-model analysis for association studies. | Xiang Zhou, Matthew Stephens | Nat Genet | 2012 | 22706312 | Yes |
| 3591 | 4838 | 1209.5 | 204.3 | 51.1 | From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. | Ara Koh, Filipe De Vadder, Petia Kovatcheva-Datchary, Fredrik Backhed | Cell | 2016 | 27259147 | No |
| 3592 | 3627 | 1209.0 | 104.3 | 34.8 | A nonparametric method for automatic correction of intensity nonuniformity in MRI data. | J G Sled, A P Zijdenbos, A C Evans | IEEE Trans Med Imaging | 1998 | 9617910 | Yes |
| 3593 | 1209 | 1209.0 | 28.8 | 28.8 | Sjögren's syndrome. | Robert I Fox | Lancet | 2005 | 16039337 | No |
| 3594 | 2418 | 1209.0 | 64.4 | 32.2 | Molecular mechanisms of T cell co-stimulation and co-inhibition. | Lieping Chen, Dallas B Flies | Nat Rev Immunol | 2013 | 23470321 | No |
| 3595 | 2418 | 1209.0 | 83.1 | 41.5 | Glycosylation in cancer: mechanisms and clinical implications. | Salome S Pinho, Celso A Reis | Nat Rev Cancer | 2015 | 26289314 | No |
| 3596 | 3625 | 1208.3 | 0.0 | 0.0 | The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. | G Blessed, B E Tomlinson, M Roth | Br J Psychiatry | 1968 | 5662937 | Yes |
| 3597 | 1208 | 1208.0 | 62.2 | 62.2 | The sociological study of stress. | L I Pearlin | J Health Soc Behav | 1989 | 2674272 | No |
| 3598 | 2416 | 1208.0 | 48.8 | 24.4 | Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. | T Hunter, B M Sefton | Proc Natl Acad Sci U S A | 1980 | 6246487 | Yes |
| 3599 | 1208 | 1208.0 | 39.8 | 39.8 | Linkage map of Escherichia coli K-12, edition 7. | B J Bachmann | Microbiol Rev | 1983 | 6348505 | No |
| 3600 | 1208 | 1208.0 | 43.7 | 43.7 | beta-Lactamases in laboratory and clinical resistance. | D M Livermore | Clin Microbiol Rev | 1995 | 8665470 | No |
| 3601 | 1208 | 1208.0 | 20.2 | 20.2 | Themes and variations on ubiquitylation. | A M Weissman | Nat Rev Mol Cell Biol | 2001 | 11265246 | No |
| 3602 | 1208 | 1208.0 | 34.5 | 34.5 | A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. | Ron Hardman | Environ Health Perspect | 2006 | 16451849 | No |
| 3603 | 1208 | 1208.0 | 32.5 | 32.5 | Redefining oxidative stress. | Dean P Jones | Antioxid Redox Signal | 2006 | 16987039 | No |
| 3604 | 2415 | 1207.5 | 65.5 | 32.8 | Rising incidence of hepatocellular carcinoma in the United States. | H B El-Serag, A C Mason | N Engl J Med | 1999 | 10072408 | Yes |
| 3605 | 2415 | 1207.5 | 71.6 | 35.8 | The diversity and biogeography of soil bacterial communities. | Noah Fierer, Robert B Jackson | Proc Natl Acad Sci U S A | 2006 | 16407148 | Yes |
| 3606 | 1207 | 1207.0 | 53.3 | 53.3 | Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). | S Safe | Crit Rev Toxicol | 1990 | 2124811 | No |
| 3607 | 1207 | 1207.0 | 40.9 | 40.9 | Spin trapping: ESR parameters of spin adducts. | G R Buettner | Free Radic Biol Med | 1987 | 2826304 | No |
| 3608 | 1207 | 1207.0 | 0.0 | 0.0 | Assay of intestinal disaccharidases. | A Dahlqvist | Anal Biochem | 1968 | 5636962 | Yes |
| 3609 | 1207 | 1207.0 | 0.0 | 0.0 | Studies on phosphatidylcholine vesicles. Formation and physical characteristics. | C Huang | Biochemistry | 1969 | 5777332 | Yes |
| 3610 | 1207 | 1207.0 | 27.5 | 27.5 | The finer things in X-ray diffraction data collection. | J W Pflugrath | Acta Crystallogr D Biol Crystallogr | 1999 | 10531521 | Yes |
| 3611 | 1207 | 1207.0 | 34.2 | 34.2 | Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. | Betsy Foxman | Am J Med | 2002 | 12113866 | No |
| 3612 | 1207 | 1207.0 | 31.6 | 31.6 | Pathogenesis of osteoporosis: concepts, conflicts, and prospects. | Lawrence G Raisz | J Clin Invest | 2005 | 16322775 | No |
| 3613 | 1207 | 1207.0 | 28.3 | 28.3 | What is principal component analysis? | Markus Ringner | Nat Biotechnol | 2008 | 18327243 | Yes |
| 3614 | 1207 | 1207.0 | 26.4 | 26.4 | Serine/threonine phosphatases: mechanism through structure. | Yigong Shi | Cell | 2009 | 19879837 | No |
| 3615 | 1206 | 1206.0 | 32.9 | 32.9 | Gibberellin metabolism and its regulation. | Shinjiro Yamaguchi | Annu Rev Plant Biol | 2008 | 18173378 | No |
| 3616 | 1206 | 1206.0 | 37.2 | 37.2 | Lanthanide luminescence for biomedical analyses and imaging. | Jean-Claude G Bunzli | Chem Rev | 2010 | 20151630 | No |
| 3617 | 1206 | 1206.0 | 53.7 | 53.7 | How Many Subjects Does It Take To Do A Regression Analysis. | S B Green | Multivariate Behav Res | 1991 | 26776715 | Yes |
| 3618 | 2411 | 1205.5 | 69.3 | 34.6 | Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. | A Fabiato, F Fabiato | J Physiol (Paris) | 1979 | 533865 | Yes |
| 3619 | 3616 | 1205.3 | 111.0 | 37.0 | Spirometric reference values from a sample of the general U.S. population. | J L Hankinson, J R Odencrantz, K B Fedan | Am J Respir Crit Care Med | 1999 | 9872837 | Yes |
| 3620 | 1205 | 1205.0 | 27.1 | 27.1 | Heterotrimeric G proteins: organizers of transmembrane signals. | E J Neer | Cell | 1995 | 7834744 | No |
| 3621 | 1205 | 1205.0 | 23.9 | 23.9 | VEGF and the quest for tumour angiogenesis factors. | Napoleone Ferrara | Nat Rev Cancer | 2002 | 12360282 | No |
| 3622 | 1205 | 1205.0 | 27.2 | 27.2 | G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. | Jeffery T Davis | Angew Chem Int Ed Engl | 2004 | 14755695 | No |
| 3623 | 6024 | 1204.8 | 148.3 | 29.7 | Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. | T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L Coffman | J Immunol | 1986 | 2419430 | Yes |
| 3624 | 2409 | 1204.5 | 75.2 | 37.6 | Burden of major musculoskeletal conditions. | Anthony D Woolf, Bruce Pfleger | Bull World Health Organ | 2003 | 14710506 | No |
| 3625 | 2408 | 1204.0 | 85.2 | 42.6 | Quantitative determination of serum triglycerides by the use of enzymes. | G Bucolo, H David | Clin Chem | 1973 | 4703655 | Yes |
| 3626 | 1204 | 1204.0 | 39.4 | 39.4 | Strategies of antioxidant defense. | H Sies | Eur J Biochem | 1993 | 7688300 | No |
| 3627 | 1204 | 1204.0 | 30.3 | 30.3 | Aptamers: an emerging class of molecules that rival antibodies in diagnostics. | S D Jayasena | Clin Chem | 1999 | 10471678 | No |
| 3628 | 1204 | 1204.0 | 54.5 | 54.5 | Development of the practice environment scale of the Nursing Work Index. | Eileen T Lake | Res Nurs Health | 2002 | 12015780 | Yes |
| 3629 | 1204 | 1204.0 | 29.1 | 29.1 | Anatomy and regulation of the central melanocortin system. | Roger D Cone | Nat Neurosci | 2005 | 15856065 | No |
| 3630 | 1204 | 1204.0 | 29.4 | 29.4 | Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. | Thomas A Wynn | J Clin Invest | 2007 | 17332879 | No |
| 3631 | 2408 | 1204.0 | 52.1 | 26.1 | Defining the role of mTOR in cancer. | David A Guertin, David M Sabatini | Cancer Cell | 2007 | 17613433 | No |
| 3632 | 1204 | 1204.0 | 37.3 | 37.3 | Graves' ophthalmopathy. | Rebecca S Bahn | N Engl J Med | 2010 | 20181974 | No |
| 3633 | 1203 | 1203.0 | 22.1 | 22.1 | Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. | Eric C Lai | Nat Genet | 2002 | 11896390 | Yes |
| 3634 | 2406 | 1203.0 | 65.8 | 32.9 | Antibacterial resistance worldwide: causes, challenges and responses. | Stuart B Levy, Bonnie Marshall | Nat Med | 2004 | 15577930 | No |
| 3635 | 2405 | 1202.5 | 48.9 | 24.4 | Multiple nuclear factors interact with the immunoglobulin enhancer sequences. | R Sen, D Baltimore | Cell | 1986 | 3091258 | Yes |
| 3636 | 2405 | 1202.5 | 181.1 | 90.5 | Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? | Fangda Leng, Paul Edison | Nat Rev Neurol | 2021 | 33318676 | No |
| 3637 | 8416 | 1202.3 | 171.0 | 24.4 | Exploration, normalization, and summaries of high density oligonucleotide array probe level data. | Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P Speed | Biostatistics | 2003 | 12925520 | Yes |
| 3638 | 1202 | 1202.0 | 38.4 | 38.4 | Biosynthesis and metabolism of endothelium-derived nitric oxide. | L J Ignarro | Annu Rev Pharmacol Toxicol | 1990 | 2188578 | No |
| 3639 | 1202 | 1202.0 | 30.7 | 30.7 | Hereditary cancer, oncogenes, and antioncogenes. | A G Knudson | Cancer Res | 1985 | 2983882 | Yes |
| 3640 | 1202 | 1202.0 | 22.0 | 22.0 | Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. | D Hanahan | Nature | 1985 | 2986015 | Yes |
| 3641 | 1202 | 1202.0 | 45.7 | 45.7 | View through a window may influence recovery from surgery. | R S Ulrich | Science | 1984 | 6143402 | Yes |
| 3642 | 1202 | 1202.0 | 25.3 | 25.3 | MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. | R N Germain | Cell | 1994 | 8293464 | No |
| 3643 | 1202 | 1202.0 | 28.7 | 28.7 | Pathogenesis of atherosclerosis. | Erling Falk | J Am Coll Cardiol | 2006 | 16631513 | Yes |
| 3644 | 3604 | 1201.3 | 195.9 | 65.3 | ShinyGO: a graphical gene-set enrichment tool for animals and plants. | Steven Xijin Ge, Dongmin Jung, Runan Yao | Bioinformatics | 2020 | 31882993 | Yes |
| 3645 | 4805 | 1201.2 | 107.0 | 26.8 | Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. | J E Walker, M Saraste, M J Runswick, N J Gay | EMBO J | 1982 | 6329717 | Yes |
| 3646 | 1201 | 1201.0 | 37.3 | 37.3 | Animal mitochondrial DNA: structure and evolution. | D R Wolstenholme | Int Rev Cytol | 1992 | 1452431 | No |
| 3647 | 1201 | 1201.0 | 40.2 | 40.2 | The pathogenesis of sepsis. | R C Bone | Ann Intern Med | 1991 | 1872494 | No |
| 3648 | 1201 | 1201.0 | 45.2 | 45.2 | Predictors of postpartum depression: an update. | C T Beck | Nurs Res | 2001 | 11570712 | Yes |
| 3649 | 1201 | 1201.0 | 28.7 | 28.7 | Solid-state nanopores. | Cees Dekker | Nat Nanotechnol | 2007 | 18654264 | No |
| 3650 | 2402 | 1201.0 | 55.5 | 27.8 | Next-generation DNA sequencing. | Jay Shendure, Hanlee Ji | Nat Biotechnol | 2008 | 18846087 | Yes |
| 3651 | 2402 | 1201.0 | 122.4 | 61.2 | Cytokine Storm. | David C Fajgenbaum, Carl H June | N Engl J Med | 2020 | 33264547 | No |
| 3652 | 2401 | 1200.5 | 58.3 | 29.1 | Shape-controlled synthesis of gold and silver nanoparticles. | Yugang Sun, Younan Xia | Science | 2002 | 12481134 | Yes |
| 3653 | 1200 | 1200.0 | 39.6 | 39.6 | Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. | M Leavitt | MedGenMed | 2001 | 11549951 | No |
| 3654 | 1200 | 1200.0 | 0.0 | 0.0 | Preliminary Trial Of Carisoprodol In Multiple Sclerosis. | B Ashworth | Practitioner | 1964 | 14143329 | Yes |
| 3655 | 1200 | 1200.0 | 55.7 | 55.7 | Root canal irrigants. | Matthias Zehnder | J Endod | 2006 | 16631834 | No |
| 3656 | 10799 | 1199.9 | 362.0 | 40.2 | A novel potent vasoconstrictor peptide produced by vascular endothelial cells. | M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T Masaki | Nature | 1988 | 2451132 | Yes |
| 3657 | 2399 | 1199.5 | 62.8 | 31.4 | The protective effects of estrogen on the cardiovascular system. | M E Mendelsohn, R H Karas | N Engl J Med | 1999 | 10362825 | No |
| 3658 | 1199 | 1199.0 | 35.4 | 35.4 | Pharmacology of cannabinoid CB1 and CB2 receptors. | R G Pertwee | Pharmacol Ther | 1997 | 9336020 | No |
| 3659 | 2398 | 1199.0 | 54.4 | 27.2 | Esophageal cancer. | Peter C Enzinger, Robert J Mayer | N Engl J Med | 2003 | 14657432 | No |
| 3660 | 1199 | 1199.0 | 23.6 | 23.6 | IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. | Yong-Jun Liu | Annu Rev Immunol | 2005 | 15771572 | No |
| 3661 | 14388 | 1199.0 | 447.8 | 37.3 | Ferroptosis: an iron-dependent form of nonapoptotic cell death. | Scott J Dixon, Kathryn M Lemberg, Michael R Lamprecht, Rachid Skouta, Eleina M Zaitsev, Caroline E Gleason, Darpan N Patel, Andras J Bauer, Alexandra M Cantley, Wan Seok Yang, Barclay Morrison, Brent R Stockwell | Cell | 2012 | 22632970 | Yes |
| 3662 | 1199 | 1199.0 | 47.7 | 47.7 | Epithelial Mesenchymal Transition in Tumor Metastasis. | Vivek Mittal | Annu Rev Pathol | 2018 | 29414248 | No |
| 3663 | 1198 | 1198.0 | 39.8 | 39.8 | An approach for the treatment of penile carcinoma. | R M Cabanas | Cancer | 1977 | 837331 | Yes |
| 3664 | 4792 | 1198.0 | 191.0 | 47.8 | The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. | L B Krupp, N G LaRocca, J Muir-Nash, A D Steinberg | Arch Neurol | 1989 | 2803071 | Yes |
| 3665 | 2396 | 1198.0 | 54.8 | 27.4 | Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. | J D McGhee, P H Von Hippel | J Mol Biol | 1974 | 4416620 | Yes |
| 3666 | 1198 | 1198.0 | 42.0 | 42.0 | Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. | H V Gelboin | Physiol Rev | 1980 | 7001511 | No |
| 3667 | 1198 | 1198.0 | 23.6 | 23.6 | Microarray data normalization and transformation. | John Quackenbush | Nat Genet | 2002 | 12454644 | No |
| 3668 | 4790 | 1197.5 | 221.9 | 55.5 | Random effects structure for confirmatory hypothesis testing: Keep it maximal. | Dale J Barr, Roger Levy, Christoph Scheepers, Harry J Tily | J Mem Lang | 2013 | 24403724 | Yes |
| 3669 | 2394 | 1197.0 | 59.5 | 29.8 | Efficient behavior of small-world networks. | V Latora, M Marchiori | Phys Rev Lett | 2001 | 11690461 | Yes |
| 3670 | 2394 | 1197.0 | 62.4 | 31.2 | Monocyte recruitment during infection and inflammation. | Chao Shi, Eric G Pamer | Nat Rev Immunol | 2011 | 21984070 | No |
| 3671 | 2393 | 1196.5 | 167.5 | 83.8 | Radiological demarcation of cemented sockets in total hip replacement. | J G DeLee, J Charnley | Clin Orthop Relat Res | 1976 | 991504 | Yes |
| 3672 | 4786 | 1196.5 | 117.8 | 29.4 | Base-calling of automated sequencer traces using phred. I. Accuracy assessment. | B Ewing, L Hillier, M C Wendl, P Green | Genome Res | 1998 | 9521921 | Yes |
| 3673 | 3589 | 1196.3 | 76.6 | 25.5 | Cellular survival: a play in three Akts. | S R Datta, A Brunet, M E Greenberg | Genes Dev | 1999 | 10579998 | No |
| 3674 | 1196 | 1196.0 | 29.0 | 29.0 | Rapid and sensitive sequence comparison with FASTP and FASTA. | W R Pearson | Methods Enzymol | 1990 | 2156132 | Yes |
| 3675 | 1196 | 1196.0 | 34.8 | 34.8 | Determinants of tumor blood flow: a review. | R K Jain | Cancer Res | 1988 | 3282647 | No |
| 3676 | 2392 | 1196.0 | 89.1 | 44.5 | The Modified Mini-Mental State (3MS) examination. | E L Teng, H C Chui | J Clin Psychiatry | 1987 | 3611032 | Yes |
| 3677 | 1196 | 1196.0 | 55.8 | 55.8 | Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. | M Rutter | Br J Psychiatry | 1985 | 3830321 | Yes |
| 3678 | 1196 | 1196.0 | 38.3 | 38.3 | Low-molecular-weight heparins. | J I Weitz | N Engl J Med | 1997 | 9278467 | No |
| 3679 | 1196 | 1196.0 | 40.3 | 40.3 | The broaden-and-build theory of positive emotions. | Barbara L Fredrickson | Philos Trans R Soc Lond B Biol Sci | 2004 | 15347528 | No |
| 3680 | 1196 | 1196.0 | 35.1 | 35.1 | Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. | Barry Halliwell | Plant Physiol | 2006 | 16760481 | Yes |
| 3681 | 1195 | 1195.0 | 31.9 | 31.9 | Pathogenesis of dengue: challenges to molecular biology. | S B Halstead | Science | 1988 | 3277268 | No |
| 3682 | 1195 | 1195.0 | 0.0 | 0.0 | Pathologic anatomy of the pancreas in juvenile diabetes mellitus. | W Gepts | Diabetes | 1965 | 5318831 | Yes |
| 3683 | 1195 | 1195.0 | 0.0 | 0.0 | The powerful placebo. | H K Beecher | J Am Med Assoc | 1955 | 13271123 | Yes |
| 3684 | 2390 | 1195.0 | 50.5 | 25.2 | Fcgamma receptors as regulators of immune responses. | Falk Nimmerjahn, Jeffrey V Ravetch | Nat Rev Immunol | 2008 | 18064051 | No |
| 3685 | 2390 | 1195.0 | 134.6 | 67.3 | miRDB: an online database for prediction of functional microRNA targets. | Yuhao Chen, Xiaowei Wang | Nucleic Acids Res | 2020 | 31504780 | Yes |
| 3686 | 2389 | 1194.5 | 97.6 | 48.8 | Thirty years and counting: finding meaning in the N400 component of the event-related brain potential (ERP). | Marta Kutas, Kara D Federmeier | Annu Rev Psychol | 2011 | 20809790 | No |
| 3687 | 2388 | 1194.0 | 98.2 | 49.1 | Rapid procedure for detection and isolation of large and small plasmids. | C I Kado, S T Liu | J Bacteriol | 1981 | 7009583 | Yes |
| 3688 | 1194 | 1194.0 | 0.0 | 0.0 | Histological demonstration of mucin after periodic acid. | J F A McMANUS | Nature | 1946 | 20995486 | Yes |
| 3689 | 2387 | 1193.5 | 65.1 | 32.5 | The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. | Laetitia Prut, Catherine Belzung | Eur J Pharmacol | 2003 | 12600700 | No |
| 3690 | 2387 | 1193.5 | 63.2 | 31.6 | Targeting hypoxia in cancer therapy. | William R Wilson, Michael P Hay | Nat Rev Cancer | 2011 | 21606941 | No |
| 3691 | 1193 | 1193.0 | 55.7 | 55.7 | Analysis of Fickian and non-Fickian drug release from polymers. | N A Peppas | Pharm Acta Helv | 1985 | 4011621 | Yes |
| 3692 | 1193 | 1193.0 | 29.2 | 29.2 | Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. | Michael J Sanderson | Mol Biol Evol | 2002 | 11752195 | Yes |
| 3693 | 1193 | 1193.0 | 0.0 | 0.0 | The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. | W G Duncombe | Clin Chim Acta | 1964 | 14122498 | Yes |
| 3694 | 1193 | 1193.0 | 31.4 | 31.4 | The complex world of WNT receptor signalling. | Christof Niehrs | Nat Rev Mol Cell Biol | 2012 | 23151663 | No |
| 3695 | 2385 | 1192.5 | 92.3 | 46.1 | Pharmaceuticals and personal care products in the environment: agents of subtle change? | C G Daughton, T A Ternes | Environ Health Perspect | 1999 | 10592150 | No |
| 3696 | 2385 | 1192.5 | 61.9 | 30.9 | An improved general amino acid replacement matrix. | Si Quang Le, Olivier Gascuel | Mol Biol Evol | 2008 | 18367465 | Yes |
| 3697 | 2385 | 1192.5 | 54.7 | 27.4 | Modes of resistance to anti-angiogenic therapy. | Gabriele Bergers, Douglas Hanahan | Nat Rev Cancer | 2008 | 18650835 | No |
| 3698 | 1192 | 1192.0 | 54.0 | 54.0 | Nontuberculous mycobacteria and associated diseases. | E Wolinsky | Am Rev Respir Dis | 1979 | 369415 | No |
| 3699 | 1192 | 1192.0 | 41.0 | 41.0 | Recommended effect size statistics for repeated measures designs. | Roger Bakeman | Behav Res Methods | 2005 | 16405133 | Yes |
| 3700 | 1192 | 1192.0 | 34.4 | 34.4 | Regulation of immune responses by prostaglandin E2. | Pawel Kalinski | J Immunol | 2012 | 22187483 | No |
| 3701 | 4766 | 1191.5 | 95.7 | 23.9 | Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. | L Alexopoulou, A C Holt, R Medzhitov, R A Flavell | Nature | 2001 | 11607032 | Yes |
| 3702 | 1191 | 1191.0 | 46.8 | 46.8 | Methods for dealing with reaction time outliers. | R Ratcliff | Psychol Bull | 1993 | 8272468 | Yes |
| 3703 | 1191 | 1191.0 | 35.2 | 35.2 | Disseminating innovations in health care. | Donald M Berwick | JAMA | 2003 | 12697800 | Yes |
| 3704 | 3572 | 1190.7 | 82.4 | 27.5 | Hepatocellular carcinoma. | Josep M Llovet, Andrew Burroughs, Jordi Bruix | Lancet | 2003 | 14667750 | No |
| 3705 | 1190 | 1190.0 | 40.8 | 40.8 | Spatially heterogeneous dynamics in supercooled liquids. | M D Ediger | Annu Rev Phys Chem | 2000 | 11031277 | Yes |
| 3706 | 2380 | 1190.0 | 55.8 | 27.9 | Effect of pegylation on pharmaceuticals. | J Milton Harris, Robert B Chess | Nat Rev Drug Discov | 2003 | 12612647 | No |
| 3707 | 2379 | 1189.5 | 124.8 | 62.4 | The neuropathological diagnosis of Alzheimer's disease. | Michael A DeTure, Dennis W Dickson | Mol Neurodegener | 2019 | 31375134 | No |
| 3708 | 1189 | 1189.0 | 26.7 | 26.7 | Molecular imaging of cancer with positron emission tomography. | Sanjiv Sam Gambhir | Nat Rev Cancer | 2002 | 12209157 | No |
| 3709 | 1189 | 1189.0 | 22.5 | 22.5 | The power and the promise of DNA methylation markers. | Peter W Laird | Nat Rev Cancer | 2003 | 12671664 | No |
| 3710 | 1189 | 1189.0 | 49.6 | 49.6 | Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. | Hannah R Snyder | Psychol Bull | 2013 | 22642228 | No |
| 3711 | 2378 | 1189.0 | 90.4 | 45.2 | The blood-brain barrier. | Richard Daneman, Alexandre Prat | Cold Spring Harb Perspect Biol | 2015 | 25561720 | No |
| 3712 | 3564 | 1188.0 | 144.1 | 48.0 | Concurrent and predictive validity of a self-reported measure of medication adherence. | D E Morisky, L W Green, D M Levine | Med Care | 1986 | 3945130 | Yes |
| 3713 | 5939 | 1187.8 | 200.9 | 40.2 | Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. | D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L Witztum | N Engl J Med | 1989 | 2648148 | No |
| 3714 | 16629 | 1187.8 | 371.3 | 26.5 | Crystallography & NMR system: A new software suite for macromolecular structure determination. | A T Brunger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L Warren | Acta Crystallogr D Biol Crystallogr | 1998 | 9757107 | Yes |
| 3715 | 2375 | 1187.5 | 63.9 | 31.9 | Anemia of chronic disease. | Guenter Weiss, Lawrence T Goodnough | N Engl J Med | 2005 | 15758012 | No |
| 3716 | 1187 | 1187.0 | 38.0 | 38.0 | Molecular biology of steroid hormone synthesis. | W L Miller | Endocr Rev | 1988 | 3061784 | No |
| 3717 | 1187 | 1187.0 | 0.0 | 0.0 | Mechanisms of lipid peroxide formation in animal tissues. | E D Wills | Biochem J | 1966 | 5964963 | Yes |
| 3718 | 1187 | 1187.0 | 37.8 | 37.8 | Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. | P S Tofts | J Magn Reson Imaging | 1997 | 9039598 | No |
| 3719 | 1187 | 1187.0 | 29.4 | 29.4 | The prefrontal cortex--an update: time is of the essence. | J M Fuster | Neuron | 2001 | 11394996 | No |
| 3720 | 2374 | 1187.0 | 53.5 | 26.8 | Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. | Daniel J Hicklin, Lee M Ellis | J Clin Oncol | 2005 | 15585754 | No |
| 3721 | 1187 | 1187.0 | 23.8 | 23.8 | Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. | Mats G L Gustafsson | Proc Natl Acad Sci U S A | 2005 | 16141335 | Yes |
| 3722 | 1187 | 1187.0 | 25.3 | 25.3 | Version 1.2 of the Crystallography and NMR system. | Axel T Brunger | Nat Protoc | 2007 | 18007608 | Yes |
| 3723 | 3561 | 1187.0 | 204.9 | 68.3 | Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles. | Aldenor G Santos, Gisele O Da Rocha, Jailson B De Andrade | Sci Rep | 2019 | 30626917 | Yes |
| 3724 | 2372 | 1186.0 | 72.3 | 36.1 | Solubilization of membranes by detergents. | A Helenius, K Simons | Biochim Biophys Acta | 1975 | 1091302 | No |
| 3725 | 1186 | 1186.0 | 27.1 | 27.1 | The impact of next-generation sequencing technology on genetics. | Elaine R Mardis | Trends Genet | 2008 | 18262675 | No |
| 3726 | 1186 | 1186.0 | 32.6 | 32.6 | Descending pathways in motor control. | Roger N Lemon | Annu Rev Neurosci | 2008 | 18558853 | No |
| 3727 | 2372 | 1186.0 | 62.7 | 31.4 | Sterile inflammation: sensing and reacting to damage. | Grace Y Chen, Gabriel Nunez | Nat Rev Immunol | 2010 | 21088683 | No |
| 3728 | 1186 | 1186.0 | 37.1 | 37.1 | The enteric nervous system and neurogastroenterology. | John B Furness | Nat Rev Gastroenterol Hepatol | 2012 | 22392290 | No |
| 3729 | 3557 | 1185.7 | 73.0 | 24.3 | Predicting coiled coils from protein sequences. | A Lupas, M Van Dyke, J Stock | Science | 1991 | 2031185 | Yes |
| 3730 | 1185 | 1185.0 | 19.5 | 19.5 | Evolution and tinkering. | F Jacob | Science | 1977 | 860134 | Yes |
| 3731 | 2370 | 1185.0 | 110.2 | 55.1 | Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. | J D Peuler, G A Johnson | Life Sci | 1977 | 904439 | Yes |
| 3732 | 2370 | 1185.0 | 51.5 | 25.8 | Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. | Javier A Menendez, Ruth Lupu | Nat Rev Cancer | 2007 | 17882277 | No |
| 3733 | 1185 | 1185.0 | 35.6 | 35.6 | Conceptual synthesis in community ecology. | Mark Vellend | Q Rev Biol | 2010 | 20565040 | No |
| 3734 | 1184 | 1184.0 | 40.7 | 40.7 | Interleukin-1 and the pathogenesis of the acute-phase response. | C A Dinarello | N Engl J Med | 1984 | 6208485 | No |
| 3735 | 5920 | 1184.0 | 124.3 | 24.9 | Electrostatics of nanosystems: application to microtubules and the ribosome. | N A Baker, D Sept, S Joseph, M J Holst, J A McCammon | Proc Natl Acad Sci U S A | 2001 | 11517324 | Yes |
| 3736 | 1184 | 1184.0 | 30.4 | 30.4 | Area deprivation and widening inequalities in US mortality, 1969-1998. | Gopal K Singh | Am J Public Health | 2003 | 12835199 | Yes |
| 3737 | 1184 | 1184.0 | 26.5 | 26.5 | The action potential in mammalian central neurons. | Bruce P Bean | Nat Rev Neurosci | 2007 | 17514198 | No |
| 3738 | 1184 | 1184.0 | 54.6 | 54.6 | Reference methods for the assessment of physical characteristics of meat. | K O Honikel | Meat Sci | 1998 | 22060626 | Yes |
| 3739 | 2367 | 1183.5 | 52.3 | 26.1 | Functions of lipid rafts in biological membranes. | D A Brown, E London | Annu Rev Cell Dev Biol | 1998 | 9891780 | No |
| 3740 | 2366 | 1183.0 | 59.6 | 29.8 | Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation. | Ivica Letunic, Peer Bork | Bioinformatics | 2007 | 17050570 | Yes |
| 3741 | 1183 | 1183.0 | 44.4 | 44.4 | Surface-enhanced Raman spectroscopy: concepts and chemical applications. | Sebastian Schlucker | Angew Chem Int Ed Engl | 2014 | 24711218 | Yes |
| 3742 | 1183 | 1183.0 | 54.3 | 54.3 | Psychedelics. | David E Nichols | Pharmacol Rev | 2016 | 26841800 | No |
| 3743 | 2365 | 1182.5 | 54.7 | 27.4 | Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. | Sharon R Browning, Brian L Browning | Am J Hum Genet | 2007 | 17924348 | Yes |
| 3744 | 2364 | 1182.0 | 68.5 | 34.2 | Mental rotation of three-dimensional objects. | R N Shepard, J Metzler | Science | 1971 | 5540314 | Yes |
| 3745 | 1182 | 1182.0 | 41.4 | 41.4 | Selective attention and the organization of visual information. | J Duncan | J Exp Psychol Gen | 1984 | 6240521 | Yes |
| 3746 | 1182 | 1182.0 | 34.3 | 34.3 | Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. | F P Guengerich | Chem Res Toxicol | 2001 | 11409933 | No |
| 3747 | 1182 | 1182.0 | 0.0 | 0.0 | The Stability of Broken Ends of Chromosomes in Zea Mays. | B McClintock | Genetics | 1941 | 17247004 | Yes |
| 3748 | 1182 | 1182.0 | 37.2 | 37.2 | Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. | Bruce S McEwen | Eur J Pharmacol | 2008 | 18282566 | No |
| 3749 | 1182 | 1182.0 | 39.2 | 39.2 | Biomedical photoacoustic imaging. | Paul Beard | Interface Focus | 2011 | 22866233 | Yes |
| 3750 | 2363 | 1181.5 | 63.0 | 31.5 | The evolution of cooperation. | R Axelrod, W D Hamilton | Science | 1981 | 7466396 | Yes |
| 3751 | 2362 | 1181.0 | 63.9 | 31.9 | The low-density lipoprotein pathway and its relation to atherosclerosis. | J L Goldstein, M S Brown | Annu Rev Biochem | 1977 | 197883 | No |
| 3752 | 1181 | 1181.0 | 30.3 | 30.3 | Quantification of beta-sheet amyloid fibril structures with thioflavin T. | H LeVine | Methods Enzymol | 1999 | 10507030 | Yes |
| 3753 | 2362 | 1181.0 | 50.8 | 25.4 | Genomic control for association studies. | B Devlin, K Roeder | Biometrics | 1999 | 11315092 | Yes |
| 3754 | 1181 | 1181.0 | 36.7 | 36.7 | The social brain in adolescence. | Sarah-Jayne Blakemore | Nat Rev Neurosci | 2008 | 18354399 | No |
| 3755 | 3543 | 1181.0 | 84.6 | 28.2 | STATs in cancer inflammation and immunity: a leading role for STAT3. | Hua Yu, Drew Pardoll, Richard Jove | Nat Rev Cancer | 2009 | 19851315 | No |
| 3756 | 1181 | 1181.0 | 42.7 | 42.7 | Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning. | Gyorgy Buzsaki | Hippocampus | 2015 | 26135716 | No |
| 3757 | 1180 | 1180.0 | 27.2 | 27.2 | Hybridization of denatured RNA transferred or dotted nitrocellulose paper. | P S Thomas | Methods Enzymol | 1983 | 6194404 | Yes |
| 3758 | 1180 | 1180.0 | 33.7 | 33.7 | Interval estimation for the difference between independent proportions: comparison of eleven methods. | R G Newcombe | Stat Med | 1998 | 9595617 | Yes |
| 3759 | 2360 | 1180.0 | 92.3 | 46.1 | Positive psychology. An introduction. | M E Seligman, M Csikszentmihalyi | Am Psychol | 2000 | 11392865 | Yes |
| 3760 | 1180 | 1180.0 | 25.4 | 25.4 | Osmotic stress signaling and osmoadaptation in yeasts. | Stefan Hohmann | Microbiol Mol Biol Rev | 2002 | 12040128 | No |
| 3761 | 4719 | 1179.8 | 109.6 | 27.4 | Isolation and characterization of exosomes from cell culture supernatants and biological fluids. | Clotilde Thery, Sebastian Amigorena, Graca Raposo, Aled Clayton | Curr Protoc Cell Biol | 2006 | 18228490 | Yes |
| 3762 | 2359 | 1179.5 | 45.8 | 22.9 | Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. | C Li, W H Wong | Proc Natl Acad Sci U S A | 2001 | 11134512 | Yes |
| 3763 | 21231 | 1179.5 | 535.0 | 29.7 | PHENIX: a comprehensive Python-based system for macromolecular structure solution. | Paul D Adams, Pavel V Afonine, Gabor Bunkoczi, Vincent B Chen, Ian W Davis, Nathaniel Echols, Jeffrey J Headd, Li-Wei Hung, Gary J Kapral, Ralf W Grosse-Kunstleve, Airlie J McCoy, Nigel W Moriarty, Robert Oeffner, Randy J Read, David C Richardson, Jane S Richardson, Thomas C Terwilliger, Peter H Zwart | Acta Crystallogr D Biol Crystallogr | 2010 | 20124702 | Yes |
| 3764 | 3538 | 1179.3 | 92.9 | 31.0 | Pathogenic Escherichia coli. | James B Kaper, James P Nataro, Harry L Mobley | Nat Rev Microbiol | 2004 | 15040260 | No |
| 3765 | 1179 | 1179.0 | 37.7 | 37.7 | Critical evaluation of energy intake using the Goldberg cut-off for energy intake:basal metabolic rate. A practical guide to its calculation, use and limitations. | A E Black | Int J Obes Relat Metab Disord | 2000 | 11033980 | Yes |
| 3766 | 2357 | 1178.5 | 59.7 | 29.9 | Using RepeatMasker to identify repetitive elements in genomic sequences. | Maja Tarailo-Graovac, Nansheng Chen | Curr Protoc Bioinformatics | 2009 | 19274634 | Yes |
| 3767 | 4709 | 1177.2 | 205.6 | 51.4 | Development of recommendations for SEMG sensors and sensor placement procedures. | H J Hermens, B Freriks, C Disselhorst-Klug, G Rau | J Electromyogr Kinesiol | 2000 | 11018445 | Yes |
| 3768 | 1177 | 1177.0 | 0.0 | 0.0 | Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. | J Altman | J Comp Neurol | 1969 | 5361244 | Yes |
| 3769 | 7062 | 1177.0 | 192.1 | 32.0 | The capsaicin receptor: a heat-activated ion channel in the pain pathway. | M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D Julius | Nature | 1997 | 9349813 | Yes |
| 3770 | 1177 | 1177.0 | 27.0 | 27.0 | Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. | Ferric C Fang | Nat Rev Microbiol | 2004 | 15378046 | No |
| 3771 | 1177 | 1177.0 | 32.0 | 32.0 | Physiology and immunology of the cholinergic antiinflammatory pathway. | Kevin J Tracey | J Clin Invest | 2007 | 17273548 | No |
| 3772 | 5883 | 1176.6 | 219.4 | 43.9 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | Open Med | 2009 | 21603045 | Yes |
| 3773 | 3529 | 1176.3 | 115.7 | 38.6 | xCell: digitally portraying the tissue cellular heterogeneity landscape. | Dvir Aran, Zicheng Hu, Atul J Butte | Genome Biol | 2017 | 29141660 | Yes |
| 3774 | 1176 | 1176.0 | 38.3 | 38.3 | Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. | P J Basser | NMR Biomed | 1995 | 8739270 | No |
| 3775 | 1176 | 1176.0 | 40.7 | 40.7 | The patient-physician relationship. Narrative medicine: a model for empathy, reflection, profession, and trust. | R Charon | JAMA | 2001 | 11597295 | Yes |
| 3776 | 2351 | 1175.5 | 84.8 | 42.4 | Required sample size to detect the mediated effect. | Matthew S Fritz, David P MacKinnon | Psychol Sci | 2007 | 17444920 | Yes |
| 3777 | 3526 | 1175.3 | 90.1 | 30.0 | In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. | Chun-Chi Liang, Ann Y Park, Jun-Lin Guan | Nat Protoc | 2007 | 17406593 | Yes |
| 3778 | 1175 | 1175.0 | 25.1 | 25.1 | Molecular cloning and expression of glycogen synthase kinase-3/factor A. | J R Woodgett | EMBO J | 1990 | 2164470 | Yes |
| 3779 | 1175 | 1175.0 | 26.6 | 26.6 | Cadherins: a molecular family important in selective cell-cell adhesion. | M Takeichi | Annu Rev Biochem | 1990 | 2197976 | No |
| 3780 | 1175 | 1175.0 | 60.4 | 60.4 | Clinical experience with impedance audiometry. | J Jerger | Arch Otolaryngol | 1970 | 5455571 | Yes |
| 3781 | 2350 | 1175.0 | 71.3 | 35.6 | Excitatory amino acids as a final common pathway for neurologic disorders. | S A Lipton, P A Rosenberg | N Engl J Med | 1994 | 7905600 | No |
| 3782 | 1175 | 1175.0 | 35.5 | 35.5 | Venous thrombosis: a multicausal disease. | F R Rosendaal | Lancet | 1999 | 10209995 | No |
| 3783 | 1175 | 1175.0 | 23.3 | 23.3 | The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. | Y Yarden | Eur J Cancer | 2001 | 11597398 | No |
| 3784 | 1175 | 1175.0 | 43.4 | 43.4 | Mental illness and/or mental health? Investigating axioms of the complete state model of health. | Corey L M Keyes | J Consult Clin Psychol | 2005 | 15982151 | Yes |
| 3785 | 1174 | 1174.0 | 46.2 | 46.2 | Presynaptic regulation of catecholamine release. | S Z Langer | Biochem Pharmacol | 1974 | 4617579 | No |
| 3786 | 2348 | 1174.0 | 74.8 | 37.4 | Extended-spectrum beta-lactamases: a clinical update. | David L Paterson, Robert A Bonomo | Clin Microbiol Rev | 2005 | 16223952 | No |
| 3787 | 1174 | 1174.0 | 26.3 | 26.3 | Pyramidal neurons: dendritic structure and synaptic integration. | Nelson Spruston | Nat Rev Neurosci | 2008 | 18270515 | No |
| 3788 | 2347 | 1173.5 | 44.3 | 22.1 | AP-1 as a regulator of cell life and death. | Eitan Shaulian, Michael Karin | Nat Cell Biol | 2002 | 11988758 | No |
| 3789 | 3519 | 1173.0 | 109.1 | 36.4 | Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. | A DeLean, P J Munson, D Rodbard | Am J Physiol | 1978 | 686171 | Yes |
| 3790 | 1173 | 1173.0 | 46.1 | 46.1 | Omega-3 fatty acids in health and disease and in growth and development. | A P Simopoulos | Am J Clin Nutr | 1991 | 1908631 | No |
| 3791 | 1173 | 1173.0 | 0.0 | 0.0 | The cytoarchitectonic organization of the spinal cord in the cat. | B Rexed | J Comp Neurol | 1952 | 14946260 | Yes |
| 3792 | 4690 | 1172.5 | 122.5 | 30.6 | C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. | P M Ridker, C H Hennekens, J E Buring, N Rifai | N Engl J Med | 2000 | 10733371 | Yes |
| 3793 | 1172 | 1172.0 | 48.6 | 48.6 | Presynaptic regulation of the release of catecholamines. | S Z Langer | Pharmacol Rev | 1980 | 6267618 | Yes |
| 3794 | 2344 | 1172.0 | 53.1 | 26.6 | Synaptic activity and the construction of cortical circuits. | L C Katz, C J Shatz | Science | 1996 | 8895456 | No |
| 3795 | 1172 | 1172.0 | 52.8 | 52.8 | Gait changes in older adults: predictors of falls or indicators of fear. | B E Maki | J Am Geriatr Soc | 1997 | 9063277 | Yes |
| 3796 | 1172 | 1172.0 | 28.6 | 28.6 | Amyloid, the presenilins and Alzheimer's disease. | J Hardy | Trends Neurosci | 1997 | 9106355 | No |
| 3797 | 7032 | 1172.0 | 196.9 | 32.8 | Prediction of coronary heart disease using risk factor categories. | P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B Kannel | Circulation | 1998 | 9603539 | Yes |
| 3798 | 1172 | 1172.0 | 21.6 | 21.6 | DNA methylation in cancer: too much, but also too little. | Melanie Ehrlich | Oncogene | 2002 | 12154403 | No |
| 3799 | 1172 | 1172.0 | 35.5 | 35.5 | A perspective on judgment and choice: mapping bounded rationality. | Daniel Kahneman | Am Psychol | 2003 | 14584987 | No |
| 3800 | 2344 | 1172.0 | 77.1 | 38.5 | Intestinal epithelial cells: regulators of barrier function and immune homeostasis. | Lance W Peterson, David Artis | Nat Rev Immunol | 2014 | 24566914 | No |
| 3801 | 2342 | 1171.0 | 103.9 | 52.0 | The aggression questionnaire. | A H Buss, M Perry | J Pers Soc Psychol | 1992 | 1403624 | Yes |
| 3802 | 1171 | 1171.0 | 31.1 | 31.1 | Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. | Mark E Bouton | Biol Psychiatry | 2002 | 12437938 | No |
| 3803 | 1171 | 1171.0 | 32.2 | 32.2 | Electrogenerated chemiluminescence and its biorelated applications. | Wujian Miao | Chem Rev | 2008 | 18505298 | No |
| 3804 | 7025 | 1170.8 | 216.2 | 36.0 | Mild cognitive impairment: clinical characterization and outcome. | R C Petersen, G E Smith, S C Waring, R J Ivnik, E G Tangalos, E Kokmen | Arch Neurol | 1999 | 10190820 | Yes |
| 3805 | 2341 | 1170.5 | 56.0 | 28.0 | A note on quantifying follow-up in studies of failure time. | M Schemper, T L Smith | Control Clin Trials | 1996 | 8889347 | Yes |
| 3806 | 1170 | 1170.0 | 22.2 | 22.2 | The ubiquitin-proteasome pathway: on protein death and cell life. | A Ciechanover | EMBO J | 1998 | 9857172 | No |
| 3807 | 1170 | 1170.0 | 26.6 | 26.6 | Toward self-organization and complex matter. | Jean-Marie Lehn | Science | 2002 | 11923524 | Yes |
| 3808 | 1170 | 1170.0 | 30.6 | 30.6 | Soil carbon sequestration impacts on global climate change and food security. | R Lal | Science | 2004 | 15192216 | Yes |
| 3809 | 1170 | 1170.0 | 26.5 | 26.5 | Liver regeneration. | George K Michalopoulos | J Cell Physiol | 2007 | 17559071 | No |
| 3810 | 1170 | 1170.0 | 45.6 | 45.6 | Fiber and prebiotics: mechanisms and health benefits. | Joanne Slavin | Nutrients | 2013 | 23609775 | No |
| 3811 | 1170 | 1170.0 | 49.6 | 49.6 | The epidemiology and impact of pain in osteoarthritis. | T Neogi | Osteoarthritis Cartilage | 2013 | 23973124 | Yes |
| 3812 | 2340 | 1170.0 | 100.2 | 50.1 | The social determinants of health: it's time to consider the causes of the causes. | Paula Braveman, Laura Gottlieb | Public Health Rep | 2014 | 24385661 | No |
| 3813 | 1170 | 1170.0 | 52.3 | 52.3 | Fibromyalgia: a clinical review. | Daniel J Clauw | JAMA | 2014 | 24737367 | No |
| 3814 | 5849 | 1169.8 | 163.1 | 32.6 | A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? | Leonardo Salmena, Laura Poliseno, Yvonne Tay, Lev Kats, Pier Paolo Pandolfi | Cell | 2011 | 21802130 | Yes |
| 3815 | 2339 | 1169.5 | 83.7 | 41.9 | Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. | A E Czeizel, I Dudas | N Engl J Med | 1992 | 1307234 | Yes |
| 3816 | 2339 | 1169.5 | 60.4 | 30.2 | The neural basis of decision making. | Joshua I Gold, Michael N Shadlen | Annu Rev Neurosci | 2007 | 17600525 | No |
| 3817 | 1169 | 1169.0 | 35.7 | 35.7 | Effect of anoxia on ion distribution in the brain. | A J Hansen | Physiol Rev | 1985 | 3880896 | No |
| 3818 | 1169 | 1169.0 | 41.8 | 41.8 | Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. | Ronald A Hites | Environ Sci Technol | 2004 | 14998004 | Yes |
| 3819 | 1169 | 1169.0 | 0.0 | 0.0 | A new microscopic principle. | D Gabor | Nature | 1948 | 18860291 | Yes |
| 3820 | 1169 | 1169.0 | 0.0 | 0.0 | Knee joint changes after meniscectomy. | T J Fairbank | J Bone Joint Surg Br | 1948 | 18894618 | Yes |
| 3821 | 1169 | 1169.0 | 78.1 | 78.1 | Antimicrobial Resistance: Implications and Costs. | Porooshat Dadgostar | Infect Drug Resist | 2019 | 31908502 | No |
| 3822 | 4673 | 1168.2 | 147.1 | 36.8 | Causal analysis approaches in Ingenuity Pathway Analysis. | Andreas Kramer, Jeff Green, Jack Pollard, Stuart Tugendreich | Bioinformatics | 2014 | 24336805 | Yes |
| 3823 | 1168 | 1168.0 | 43.6 | 43.6 | Socioeconomic disadvantage and child development. | V C McLoyd | Am Psychol | 1998 | 9491747 | No |
| 3824 | 2336 | 1168.0 | 48.7 | 24.4 | Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. | P E Wright, H J Dyson | J Mol Biol | 1999 | 10550212 | No |
| 3825 | 2336 | 1168.0 | 87.6 | 43.8 | NAFLD: a multisystem disease. | Christopher D Byrne, Giovanni Targher | J Hepatol | 2015 | 25920090 | No |
| 3826 | 3502 | 1167.3 | 0.0 | 0.0 | Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. | A L Shapiro, E Vinuela, J V Maizel | Biochem Biophys Res Commun | 1967 | 4861258 | Yes |
| 3827 | 1167 | 1167.0 | 37.2 | 37.2 | Distracted and confused?: selective attention under load. | Nilli Lavie | Trends Cogn Sci | 2005 | 15668100 | No |
| 3828 | 1167 | 1167.0 | 30.6 | 30.6 | The role of acetylcholine in learning and memory. | Michael E Hasselmo | Curr Opin Neurobiol | 2006 | 17011181 | No |
| 3829 | 2334 | 1167.0 | 71.0 | 35.5 | Neural regulation of endocrine and autonomic stress responses. | Yvonne M Ulrich-Lai, James P Herman | Nat Rev Neurosci | 2009 | 19469025 | No |
| 3830 | 2334 | 1167.0 | 90.2 | 45.1 | Perceived discrimination and health: a meta-analytic review. | Elizabeth A Pascoe, Laura Smart Richman | Psychol Bull | 2009 | 19586161 | Yes |
| 3831 | 2334 | 1167.0 | 87.4 | 43.7 | Loneliness matters: a theoretical and empirical review of consequences and mechanisms. | Louise C Hawkley, John T Cacioppo | Ann Behav Med | 2010 | 20652462 | No |
| 3832 | 3500 | 1166.7 | 101.7 | 33.9 | Depression: a new animal model sensitive to antidepressant treatments. | R D Porsolt, M Le Pichon, M Jalfre | Nature | 1977 | 559941 | Yes |
| 3833 | 1166 | 1166.0 | 44.9 | 44.9 | A measure of anxiety symptoms among children. | S H Spence | Behav Res Ther | 1998 | 9648330 | Yes |
| 3834 | 1166 | 1166.0 | 25.3 | 25.3 | The mitochondrial genome: structure, transcription, translation and replication. | J W Taanman | Biochim Biophys Acta | 1999 | 10076021 | No |
| 3835 | 1166 | 1166.0 | 44.6 | 44.6 | Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world. | Murray B Isman | Annu Rev Entomol | 2006 | 16332203 | No |
| 3836 | 1166 | 1166.0 | 0.0 | 0.0 | Observations on the isolated phrenic nerve diaphragm preparation of the rat. | E Bulbring | Br J Pharmacol Chemother | 1946 | 20999334 | Yes |
| 3837 | 1165 | 1165.0 | 46.1 | 46.1 | Subjective well-being. The science of happiness and a proposal for a national index. | E Diener | Am Psychol | 2000 | 11392863 | Yes |
| 3838 | 1165 | 1165.0 | 30.5 | 30.5 | Looking into the functional architecture of the brain with diffusion MRI. | Denis Le Bihan | Nat Rev Neurosci | 2003 | 12778119 | No |
| 3839 | 4660 | 1165.0 | 131.0 | 32.8 | A role for mitochondria in NLRP3 inflammasome activation. | Rongbin Zhou, Amir S Yazdi, Philippe Menu, Jurg Tschopp | Nature | 2011 | 21124315 | Yes |
| 3840 | 2329 | 1164.5 | 91.2 | 45.6 | Understanding face recognition. | V Bruce, A Young | Br J Psychol | 1986 | 3756376 | Yes |
| 3841 | 2329 | 1164.5 | 51.5 | 25.8 | Toll-like receptors in the induction of the innate immune response. | A Aderem, R J Ulevitch | Nature | 2000 | 10963608 | No |
| 3842 | 1164 | 1164.0 | 0.0 | 0.0 | Biogenic amines and the states of sleep. | M Jouvet | Science | 1969 | 4303225 | No |
| 3843 | 1164 | 1164.0 | 27.6 | 27.6 | Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. | M M Tirion | Phys Rev Lett | 1996 | 10063201 | Yes |
| 3844 | 1164 | 1164.0 | 35.9 | 35.9 | Leishmaniasis. | B L Herwaldt | Lancet | 1999 | 10513726 | No |
| 3845 | 2328 | 1164.0 | 45.9 | 22.9 | NF-kappaB at the crossroads of life and death. | Michael Karin, Anning Lin | Nat Immunol | 2002 | 11875461 | No |
| 3846 | 1164 | 1164.0 | 0.0 | 0.0 | The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. | J Vague | Am J Clin Nutr | 1956 | 13282851 | Yes |
| 3847 | 1164 | 1164.0 | 0.0 | 0.0 | A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. | J B Brown | Biochem J | 1955 | 14389222 | Yes |
| 3848 | 1164 | 1164.0 | 29.9 | 29.9 | Metagenomics: application of genomics to uncultured microorganisms. | Jo Handelsman | Microbiol Mol Biol Rev | 2004 | 15590779 | No |
| 3849 | 1164 | 1164.0 | 48.2 | 48.2 | Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance. | Philip C Calder | Biochim Biophys Acta | 2015 | 25149823 | No |
| 3850 | 2327 | 1163.5 | 74.7 | 37.4 | Hearing lips and seeing voices. | H McGurk, J MacDonald | Nature | 1976 | 1012311 | Yes |
| 3851 | 2327 | 1163.5 | 64.3 | 32.1 | Cu-catalyzed azide-alkyne cycloaddition. | Morten Meldal, Christian Wenzel Tornoe | Chem Rev | 2008 | 18698735 | No |
| 3852 | 1163 | 1163.0 | 47.8 | 47.8 | A review of psychological risk factors in back and neck pain. | S J Linton | Spine (Phila Pa 1976) | 2000 | 10788861 | No |
| 3853 | 1163 | 1163.0 | 20.6 | 20.6 | 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. | Judith K Christman | Oncogene | 2002 | 12154409 | No |
| 3854 | 1163 | 1163.0 | 0.0 | 0.0 | The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume. | C D Murray | Proc Natl Acad Sci U S A | 1926 | 16576980 | Yes |
| 3855 | 1163 | 1163.0 | 40.0 | 40.0 | Supramolecular binding thermodynamics by dispersion-corrected density functional theory. | Stefan Grimme | Chemistry | 2012 | 22782805 | Yes |
| 3856 | 2324 | 1162.0 | 64.1 | 32.0 | Protein oxidation in aging, disease, and oxidative stress. | B S Berlett, E R Stadtman | J Biol Chem | 1997 | 9252331 | No |
| 3857 | 2323 | 1161.5 | 52.8 | 26.4 | Growth of a rat neuroblastoma cell line in serum-free supplemented medium. | J E Bottenstein, G H Sato | Proc Natl Acad Sci U S A | 1979 | 284369 | Yes |
| 3858 | 2322 | 1161.0 | 71.7 | 35.9 | Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. | R J Ginsberg, L V Rubinstein | Ann Thorac Surg | 1995 | 7677489 | Yes |
| 3859 | 3483 | 1161.0 | 75.0 | 25.0 | A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. | M Serrano, G J Hannon, D Beach | Nature | 1993 | 8259215 | Yes |
| 3860 | 1161 | 1161.0 | 22.5 | 22.5 | Regulation of phosphoinositide-specific phospholipase C. | S G Rhee | Annu Rev Biochem | 2001 | 11395409 | No |
| 3861 | 2322 | 1161.0 | 68.1 | 34.0 | Collagen structure and stability. | Matthew D Shoulders, Ronald T Raines | Annu Rev Biochem | 2009 | 19344236 | No |
| 3862 | 1161 | 1161.0 | 32.8 | 32.8 | Voltage-gated calcium channels. | William A Catterall | Cold Spring Harb Perspect Biol | 2011 | 21746798 | No |
| 3863 | 2321 | 1160.5 | 54.7 | 27.4 | Cellular uptake of the tat protein from human immunodeficiency virus. | A D Frankel, C O Pabo | Cell | 1988 | 2849510 | Yes |
| 3864 | 2321 | 1160.5 | 0.0 | 0.0 | Cortisone in ulcerative colitis; final report on a therapeutic trial. | S C Truelove, L J Witts | Br Med J | 1955 | 13260656 | Yes |
| 3865 | 1160 | 1160.0 | 43.0 | 43.0 | Attention, similarity, and the identification-categorization relationship. | R M Nosofsky | J Exp Psychol Gen | 1986 | 2937873 | Yes |
| 3866 | 3480 | 1160.0 | 96.5 | 32.2 | Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. | M K Parmar, V Torri, L Stewart | Stat Med | 1998 | 9921604 | Yes |
| 3867 | 1160 | 1160.0 | 25.8 | 25.8 | Fluorescence spectroscopy of single biomolecules. | S Weiss | Science | 1999 | 10073925 | No |
| 3868 | 1160 | 1160.0 | 31.2 | 31.2 | Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. | Christof M Niemeyer | Angew Chem Int Ed Engl | 2001 | 29712109 | No |
| 3869 | 2319 | 1159.5 | 74.2 | 37.1 | Role of oxidized low density lipoprotein in atherogenesis. | J L Witztum, D Steinberg | J Clin Invest | 1991 | 1752940 | No |
| 3870 | 2319 | 1159.5 | 62.2 | 31.1 | Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. | Donald E Owens, Nicholas A Peppas | Int J Pharm | 2006 | 16303268 | No |
| 3871 | 3478 | 1159.3 | 109.7 | 36.6 | DNA methylation and its basic function. | Lisa D Moore, Thuc Le, Guoping Fan | Neuropsychopharmacology | 2013 | 22781841 | No |
| 3872 | 1159 | 1159.0 | 28.3 | 28.3 | BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. | O Gascuel | Mol Biol Evol | 1997 | 9254330 | Yes |
| 3873 | 1159 | 1159.0 | 22.0 | 22.0 | Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. | R A Frye | Biochem Biophys Res Commun | 2000 | 10873683 | Yes |
| 3874 | 2318 | 1159.0 | 0.0 | 0.0 | Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. | R W Butcher, E W Sutherland | J Biol Chem | 1962 | 13875173 | Yes |
| 3875 | 2318 | 1159.0 | 88.2 | 44.1 | Mechanisms of hepatic stellate cell activation. | Takuma Tsuchida, Scott L Friedman | Nat Rev Gastroenterol Hepatol | 2017 | 28487545 | No |
| 3876 | 3476 | 1158.7 | 153.5 | 51.2 | Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. | Neil M Davies, Michael V Holmes, George Davey Smith | BMJ | 2018 | 30002074 | Yes |
| 3877 | 2317 | 1158.5 | 71.3 | 35.6 | ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. | Graham Noctor, Christine H Foyer | Annu Rev Plant Physiol Plant Mol Biol | 1998 | 15012235 | Yes |
| 3878 | 2317 | 1158.5 | 75.0 | 37.5 | Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. | Ivan Sondi, Branka Salopek-Sondi | J Colloid Interface Sci | 2004 | 15158396 | Yes |
| 3879 | 1158 | 1158.0 | 32.7 | 32.7 | Diseases of the mitochondrial DNA. | D C Wallace | Annu Rev Biochem | 1992 | 1497308 | No |
| 3880 | 1158 | 1158.0 | 0.0 | 0.0 | Selective coronary arteriography. I. A percutaneous transfemoral technic. | M P Judkins | Radiology | 1967 | 6048074 | Yes |
| 3881 | 8106 | 1158.0 | 144.3 | 20.6 | The human genome browser at UCSC. | W James Kent, Charles W Sugnet, Terrence S Furey, Krishna M Roskin, Tom H Pringle, Alan M Zahler, David Haussler | Genome Res | 2002 | 12045153 | Yes |
| 3882 | 2316 | 1158.0 | 63.2 | 31.6 | A general purpose model for the condensed phases of water: TIP4P/2005. | J L F Abascal, C Vega | J Chem Phys | 2005 | 16392929 | Yes |
| 3883 | 1158 | 1158.0 | 25.9 | 25.9 | Personal genomes: The case of the missing heritability. | Brendan Maher | Nature | 2008 | 18987709 | No |
| 3884 | 1158 | 1158.0 | 36.1 | 36.1 | Outer membrane permeability and antibiotic resistance. | Anne H Delcour | Biochim Biophys Acta | 2009 | 19100346 | No |
| 3885 | 2315 | 1157.5 | 71.4 | 35.7 | Nitric oxide synthases in mammals. | R G Knowles, S Moncada | Biochem J | 1994 | 7510950 | No |
| 3886 | 4630 | 1157.5 | 123.5 | 30.9 | Wound repair and regeneration. | Geoffrey C Gurtner, Sabine Werner, Yann Barrandon, Michael T Longaker | Nature | 2008 | 18480812 | No |
| 3887 | 1157 | 1157.0 | 33.8 | 33.8 | Cholesterol and the cell membrane. | P L Yeagle | Biochim Biophys Acta | 1985 | 3904832 | No |
| 3888 | 1157 | 1157.0 | 32.0 | 32.0 | Glutathione and its role in cellular functions. | H Sies | Free Radic Biol Med | 1999 | 10569624 | No |
| 3889 | 1157 | 1157.0 | 33.8 | 33.8 | Invited review: Aging and sarcopenia. | Timothy J Doherty | J Appl Physiol (1985) | 2003 | 12970377 | No |
| 3890 | 2314 | 1157.0 | 103.5 | 51.8 | Biological Functions of Autophagy Genes: A Disease Perspective. | Beth Levine, Guido Kroemer | Cell | 2019 | 30633901 | No |
| 3891 | 2313 | 1156.5 | 56.0 | 28.0 | Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. | M J Casadaban, S N Cohen | J Mol Biol | 1980 | 6997493 | Yes |
| 3892 | 3468 | 1156.0 | 83.5 | 27.8 | High resolution two-dimensional electrophoresis of basic as well as acidic proteins. | P Z O'Farrell, H M Goodman, P H O'Farrell | Cell | 1977 | 23215 | Yes |
| 3893 | 4624 | 1156.0 | 130.5 | 32.6 | voom: Precision weights unlock linear model analysis tools for RNA-seq read counts. | Charity W Law, Yunshun Chen, Wei Shi, Gordon K Smyth | Genome Biol | 2014 | 24485249 | Yes |
| 3894 | 1155 | 1155.0 | 0.0 | 0.0 | RNA metabolism in the HeLa cell nucleus. | S Penman | J Mol Biol | 1966 | 5961144 | Yes |
| 3895 | 1155 | 1155.0 | 25.3 | 25.3 | Stem cells in the central nervous system. | R McKay | Science | 1997 | 9082987 | No |
| 3896 | 2310 | 1155.0 | 44.1 | 22.1 | Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. | R Daniel Gietz, Robin A Woods | Methods Enzymol | 2002 | 12073338 | Yes |
| 3897 | 1155 | 1155.0 | 34.1 | 34.1 | Ion suppression in mass spectrometry. | Thomas M Annesley | Clin Chem | 2003 | 12816898 | No |
| 3898 | 1155 | 1155.0 | 0.0 | 0.0 | A sensitive method for the assay of 5-hydroxytryptamine. | J R Vane | Br J Pharmacol Chemother | 1957 | 13460242 | Yes |
| 3899 | 4618 | 1154.5 | 124.0 | 31.0 | REVIGO summarizes and visualizes long lists of gene ontology terms. | Fran Supek, Matko Bosnjak, Nives Skunca, Tomislav Smuc | PLoS One | 2011 | 21789182 | Yes |
| 3900 | 1154 | 1154.0 | 0.0 | 0.0 | Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. | S Irwin | Psychopharmacologia | 1968 | 5679627 | Yes |
| 3901 | 1154 | 1154.0 | 36.0 | 36.0 | Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. | W Sieghart | Pharmacol Rev | 1995 | 7568326 | No |
| 3902 | 1154 | 1154.0 | 23.9 | 23.9 | Differentiation and proliferation of hematopoietic stem cells. | M Ogawa | Blood | 1993 | 8499622 | No |
| 3903 | 1154 | 1154.0 | 31.4 | 31.4 | Omega-3 fatty acids in inflammation and autoimmune diseases. | Artemis P Simopoulos | J Am Coll Nutr | 2002 | 12480795 | No |
| 3904 | 1154 | 1154.0 | 28.5 | 28.5 | NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. | Weihai Ying | Antioxid Redox Signal | 2008 | 18020963 | No |
| 3905 | 2307 | 1153.5 | 92.8 | 46.4 | Glutathione reductase. | I Carlberg, B Mannervik | Methods Enzymol | 1985 | 3003504 | Yes |
| 3906 | 2307 | 1153.5 | 51.6 | 25.8 | An energy budget for signaling in the grey matter of the brain. | D Attwell, S B Laughlin | J Cereb Blood Flow Metab | 2001 | 11598490 | No |
| 3907 | 1153 | 1153.0 | 28.6 | 28.6 | DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. | J F Ward | Prog Nucleic Acid Res Mol Biol | 1988 | 3065826 | No |
| 3908 | 1153 | 1153.0 | 0.0 | 0.0 | The moulding of senescence by natural selection. | W D Hamilton | J Theor Biol | 1966 | 6015424 | Yes |
| 3909 | 1153 | 1153.0 | 21.6 | 21.6 | The development of neural stem cells. | S Temple | Nature | 2001 | 11689956 | No |
| 3910 | 1153 | 1153.0 | 34.6 | 34.6 | Innate immunity of fish (overview). | Bergljot Magnadottir | Fish Shellfish Immunol | 2006 | 15950491 | No |
| 3911 | 1153 | 1153.0 | 24.4 | 24.4 | Phenotypic plasticity and the epigenetics of human disease. | Andrew P Feinberg | Nature | 2007 | 17522677 | No |
| 3912 | 1153 | 1153.0 | 45.2 | 45.2 | Cancer-related fatigue--mechanisms, risk factors, and treatments. | Julienne E Bower | Nat Rev Clin Oncol | 2014 | 25113839 | No |
| 3913 | 2305 | 1152.5 | 63.0 | 31.5 | Oxidative stress, caloric restriction, and aging. | R S Sohal, R Weindruch | Science | 1996 | 8658196 | No |
| 3914 | 2305 | 1152.5 | 49.4 | 24.7 | GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor. | Sean Davis, Paul S Meltzer | Bioinformatics | 2007 | 17496320 | Yes |
| 3915 | 4609 | 1152.2 | 148.7 | 37.2 | The cholinergic hypothesis of geriatric memory dysfunction. | R T Bartus, R L Dean, B Beer, A S Lippa | Science | 1982 | 7046051 | No |
| 3916 | 4609 | 1152.2 | 0.0 | 0.0 | The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. | P J Randle, P B Garland, C N Hales, E A Newsholme | Lancet | 1963 | 13990765 | Yes |
| 3917 | 2304 | 1152.0 | 70.7 | 35.4 | Polymyositis and dermatomyositis (second of two parts). | A Bohan, J B Peter | N Engl J Med | 1975 | 1089199 | No |
| 3918 | 2304 | 1152.0 | 47.8 | 23.9 | A survey of telomerase activity in human cancer. | J W Shay, S Bacchetti | Eur J Cancer | 1997 | 9282118 | No |
| 3919 | 1152 | 1152.0 | 38.3 | 38.3 | Reducing children's television viewing to prevent obesity: a randomized controlled trial. | T N Robinson | JAMA | 1999 | 10546696 | Yes |
| 3920 | 1152 | 1152.0 | 29.0 | 29.0 | Nitric oxide, oxidants, and protein tyrosine nitration. | Rafael Radi | Proc Natl Acad Sci U S A | 2004 | 15020765 | Yes |
| 3921 | 1152 | 1152.0 | 28.6 | 28.6 | Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. | Frank Wurthner | Chem Commun (Camb) | 2004 | 15263926 | Yes |
| 3922 | 2303 | 1151.5 | 45.7 | 22.9 | Homeobox genes and axial patterning. | W McGinnis, R Krumlauf | Cell | 1992 | 1346368 | No |
| 3923 | 2303 | 1151.5 | 64.1 | 32.0 | Plasminogen: purification from human plasma by affinity chromatography. | D G Deutsch, E T Mertz | Science | 1970 | 5475635 | Yes |
| 3924 | 1151 | 1151.0 | 0.0 | 0.0 | The tragedy of the commons. The population problem has no technical solution; it requires a fundamental extension in morality. | G Hardin | Science | 1968 | 5699198 | Yes |
| 3925 | 1151 | 1151.0 | 24.9 | 24.9 | Alpha-synuclein and neurodegenerative diseases. | M Goedert | Nat Rev Neurosci | 2001 | 11433374 | No |
| 3926 | 1151 | 1151.0 | 30.3 | 30.3 | Hybridization as an invasion of the genome. | James Mallet | Trends Ecol Evol | 2005 | 16701374 | Yes |
| 3927 | 5753 | 1150.6 | 206.2 | 41.2 | A new clinical scale for the staging of dementia. | C P Hughes, L Berg, W L Danziger, L A Coben, R L Martin | Br J Psychiatry | 1982 | 7104545 | Yes |
| 3928 | 1150 | 1150.0 | 32.4 | 32.4 | DNA topoisomerases. | M Gellert | Annu Rev Biochem | 1981 | 6267993 | No |
| 3929 | 1150 | 1150.0 | 31.3 | 31.3 | The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. | David S Ludwig | JAMA | 2002 | 11988062 | No |
| 3930 | 1150 | 1150.0 | 29.7 | 29.7 | Telomere length measurement by a novel monochrome multiplex quantitative PCR method. | Richard M Cawthon | Nucleic Acids Res | 2009 | 19129229 | Yes |
| 3931 | 2299 | 1149.5 | 74.0 | 37.0 | Stool form scale as a useful guide to intestinal transit time. | S J Lewis, K W Heaton | Scand J Gastroenterol | 1997 | 9299672 | Yes |
| 3932 | 2299 | 1149.5 | 77.1 | 38.5 | Shaping functional architecture by oscillatory alpha activity: gating by inhibition. | Ole Jensen, Ali Mazaheri | Front Hum Neurosci | 2010 | 21119777 | Yes |
| 3933 | 3448 | 1149.3 | 86.6 | 28.9 | Functional diversity of helper T lymphocytes. | A K Abbas, K M Murphy, A Sher | Nature | 1996 | 8893001 | No |
| 3934 | 1149 | 1149.0 | 26.5 | 26.5 | Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. | D L Coleman | Diabetologia | 1978 | 350680 | No |
| 3935 | 1149 | 1149.0 | 94.6 | 94.6 | Fibula free flap: a new method of mandible reconstruction. | D A Hidalgo | Plast Reconstr Surg | 1989 | 2734406 | Yes |
| 3936 | 2298 | 1149.0 | 92.0 | 46.0 | Visual search and stimulus similarity. | J Duncan, G W Humphreys | Psychol Rev | 1989 | 2756067 | Yes |
| 3937 | 1149 | 1149.0 | 0.0 | 0.0 | The stereotaxic method and radiosurgery of the brain. | L Leksell | Acta Chir Scand | 1951 | 14914373 | Yes |
| 3938 | 2298 | 1149.0 | 58.2 | 29.1 | The NF-kappaB family of transcription factors and its regulation. | Andrea Oeckinghaus, Sankar Ghosh | Cold Spring Harb Perspect Biol | 2009 | 20066092 | No |
| 3939 | 1149 | 1149.0 | 45.5 | 45.5 | A comprehensive review on metabolic syndrome. | Jaspinder Kaur | Cardiol Res Pract | 2014 | 24711954 | No |
| 3940 | 2297 | 1148.5 | 47.8 | 23.9 | Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. | G A Gonzalez, M R Montminy | Cell | 1989 | 2573431 | Yes |
| 3941 | 1148 | 1148.0 | 21.3 | 21.3 | Structure of chromatin. | R D Kornberg | Annu Rev Biochem | 1977 | 332067 | No |
| 3942 | 1148 | 1148.0 | 26.2 | 26.2 | Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. | D B Clewell | J Bacteriol | 1972 | 4336693 | Yes |
| 3943 | 1148 | 1148.0 | 0.0 | 0.0 | Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. | C M Venkatachalam | Biopolymers | 1968 | 5685102 | Yes |
| 3944 | 1148 | 1148.0 | 27.3 | 27.3 | Molecular drive: a cohesive mode of species evolution. | G Dover | Nature | 1982 | 7110332 | Yes |
| 3945 | 3443 | 1147.7 | 95.8 | 31.9 | Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. | R Schreck, P Rieber, P A Baeuerle | EMBO J | 1991 | 2065663 | Yes |
| 3946 | 1147 | 1147.0 | 61.3 | 61.3 | The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. | G A Ilizarov | Clin Orthop Relat Res | 1989 | 2912628 | Yes |
| 3947 | 1147 | 1147.0 | 27.6 | 27.6 | The neurobiology of consolidations, or, how stable is the engram? | Yadin Dudai | Annu Rev Psychol | 2004 | 14744210 | No |
| 3948 | 1147 | 1147.0 | 28.2 | 28.2 | Targeting cancer metabolism: a therapeutic window opens. | Matthew G Vander Heiden | Nat Rev Drug Discov | 2011 | 21878982 | No |
| 3949 | 1147 | 1147.0 | 51.8 | 51.8 | Socioeconomic inequalities and mental health problems in children and adolescents: a systematic review. | Franziska Reiss | Soc Sci Med | 2013 | 23746605 | Yes |
| 3950 | 3440 | 1146.7 | 103.4 | 34.5 | Foreign body reaction to biomaterials. | James M Anderson, Analiz Rodriguez, David T Chang | Semin Immunol | 2008 | 18162407 | No |
| 3951 | 2293 | 1146.5 | 59.4 | 29.7 | The oxytocin receptor system: structure, function, and regulation. | G Gimpl, F Fahrenholz | Physiol Rev | 2001 | 11274341 | No |
| 3952 | 2293 | 1146.5 | 0.0 | 0.0 | Modified reagents for determination of urea and ammonia. | A L Chaney, E P Marbach | Clin Chem | 1962 | 13878063 | Yes |
| 3953 | 1146 | 1146.0 | 44.2 | 44.2 | Perceptual selectivity for color and form. | J Theeuwes | Percept Psychophys | 1992 | 1620571 | No |
| 3954 | 1146 | 1146.0 | 45.7 | 45.7 | An advanced test of theory of mind: understanding of story characters' thoughts and feelings by able autistic, mentally handicapped, and normal children and adults. | F G Happe | J Autism Dev Disord | 1994 | 8040158 | Yes |
| 3955 | 1146 | 1146.0 | 34.8 | 34.8 | Limbic-cortical dysregulation: a proposed model of depression. | H S Mayberg | J Neuropsychiatry Clin Neurosci | 1997 | 9276848 | No |
| 3956 | 1146 | 1146.0 | 0.0 | 0.0 | Motivation reconsidered: the concept of competence. | R W White | Psychol Rev | 1959 | 13844397 | Yes |
| 3957 | 3437 | 1145.7 | 79.3 | 26.4 | Mitochondria, oxidants, and aging. | Robert S Balaban, Shino Nemoto, Toren Finkel | Cell | 2005 | 15734681 | No |
| 3958 | 3436 | 1145.3 | 69.9 | 23.3 | Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. | Paola Scaffidi, Tom Misteli, Marco E Bianchi | Nature | 2002 | 12110890 | Yes |
| 3959 | 1145 | 1145.0 | 44.3 | 44.3 | Radioimmunological determination of human C-peptide in serum. | L G Heding | Diabetologia | 1975 | 1239396 | Yes |
| 3960 | 1145 | 1145.0 | 35.1 | 35.1 | Unstable angina. A classification. | E Braunwald | Circulation | 1989 | 2752565 | Yes |
| 3961 | 1145 | 1145.0 | 17.1 | 17.1 | Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. | J J Hopfield | Proc Natl Acad Sci U S A | 1974 | 4530290 | Yes |
| 3962 | 1145 | 1145.0 | 0.0 | 0.0 | Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. | D L Morris | Science | 1948 | 17814729 | Yes |
| 3963 | 1145 | 1145.0 | 27.3 | 27.3 | Mucins in cancer: function, prognosis and therapy. | Donald W Kufe | Nat Rev Cancer | 2009 | 19935676 | No |
| 3964 | 1145 | 1145.0 | 40.4 | 40.4 | The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium. | James A Imlay | Nat Rev Microbiol | 2013 | 23712352 | No |
| 3965 | 2289 | 1144.5 | 77.7 | 38.9 | Wine, alcohol, platelets, and the French paradox for coronary heart disease. | S Renaud, M De Lorgeril | Lancet | 1992 | 1351198 | Yes |
| 3966 | 2289 | 1144.5 | 0.0 | 0.0 | Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. | H H Ussing, K Zerahn | Acta Physiol Scand | 1951 | 14868510 | Yes |
| 3967 | 2289 | 1144.5 | 80.0 | 40.0 | Fundamentals of cancer metabolism. | Ralph J DeBerardinis, Navdeep S Chandel | Sci Adv | 2016 | 27386546 | No |
| 3968 | 2289 | 1144.5 | 92.4 | 46.2 | Mechanism and medical implications of mammalian autophagy. | Ivan Dikic, Zvulun Elazar | Nat Rev Mol Cell Biol | 2018 | 29618831 | No |
| 3969 | 4577 | 1144.2 | 117.6 | 29.4 | Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. | H Nielsen, J Engelbrecht, S Brunak, G Von Heijne | Protein Eng | 1997 | 9051728 | Yes |
| 3970 | 4577 | 1144.2 | 91.3 | 22.8 | DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. | M Okano, D W Bell, D A Haber, E Li | Cell | 1999 | 10555141 | Yes |
| 3971 | 11441 | 1144.1 | 438.1 | 43.8 | The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. | Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gotzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David Moher | PLoS Med | 2009 | 19621070 | No |
| 3972 | 1144 | 1144.0 | 29.4 | 29.4 | Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. | I J Fidler | Cancer Res | 1990 | 1698118 | Yes |
| 3973 | 1144 | 1144.0 | 28.5 | 28.5 | Allelic discrimination using fluorogenic probes and the 5' nuclease assay. | K J Livak | Genet Anal | 1999 | 10084106 | Yes |
| 3974 | 1144 | 1144.0 | 0.0 | 0.0 | Inherited Antithrombin Deficiency Causing Thrombophilia. | O Egeberg | Thromb Diath Haemorrh | 1965 | 14347873 | Yes |
| 3975 | 1143 | 1143.0 | 20.0 | 20.0 | Shrinkage necrosis: a distinct mode of cellular death. | J F Kerr | J Pathol | 1971 | 4108566 | Yes |
| 3976 | 1143 | 1143.0 | 31.1 | 31.1 | An improved fluorometric assay for DNA. | R T Hinegardner | Anal Biochem | 1971 | 5544593 | Yes |
| 3977 | 1143 | 1143.0 | 25.6 | 25.6 | Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. | T Ikemura | J Mol Biol | 1981 | 6175758 | Yes |
| 3978 | 1143 | 1143.0 | 0.0 | 0.0 | A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. | R D Hotchkiss | Arch Biochem | 1948 | 18921848 | Yes |
| 3979 | 1143 | 1143.0 | 50.1 | 50.1 | The theory of planned behaviour: reactions and reflections. | Icek Ajzen | Psychol Health | 2011 | 21929476 | No |
| 3980 | 3428 | 1142.7 | 87.7 | 29.2 | Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. | G M Wahl, M Stern, G R Stark | Proc Natl Acad Sci U S A | 1979 | 291033 | Yes |
| 3981 | 2285 | 1142.5 | 103.9 | 52.0 | Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. | J B Mulliken, J Glowacki | Plast Reconstr Surg | 1982 | 7063565 | Yes |
| 3982 | 2285 | 1142.5 | 78.4 | 39.2 | Microbial interactions: from networks to models. | Karoline Faust, Jeroen Raes | Nat Rev Microbiol | 2012 | 22796884 | No |
| 3983 | 2285 | 1142.5 | 63.2 | 31.6 | DNA methylation: roles in mammalian development. | Zachary D Smith, Alexander Meissner | Nat Rev Genet | 2013 | 23400093 | No |
| 3984 | 2284 | 1142.0 | 60.4 | 30.2 | Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. | L Pellerin, P J Magistretti | Proc Natl Acad Sci U S A | 1994 | 7938003 | Yes |
| 3985 | 1142 | 1142.0 | 29.1 | 29.1 | The emotional brain, fear, and the amygdala. | Joseph LeDoux | Cell Mol Neurobiol | 2003 | 14514027 | No |
| 3986 | 2284 | 1142.0 | 103.4 | 51.7 | Introduction to the human gut microbiota. | Elizabeth Thursby, Nathalie Juge | Biochem J | 2017 | 28512250 | No |
| 3987 | 10274 | 1141.6 | 333.9 | 37.1 | Robust enumeration of cell subsets from tissue expression profiles. | Aaron M Newman, Chih Long Liu, Michael R Green, Andrew J Gentles, Weiguo Feng, Yue Xu, Chuong D Hoang, Maximilian Diehn, Ash A Alizadeh | Nat Methods | 2015 | 25822800 | Yes |
| 3988 | 1141 | 1141.0 | 0.0 | 0.0 | Diffusion-in-gel methods for immunological analysis. II. | O Ouchterlony | Prog Allergy | 1962 | 14482809 | Yes |
| 3989 | 1141 | 1141.0 | 38.7 | 38.7 | Targeting metastasis. | Patricia S Steeg | Nat Rev Cancer | 2016 | 27009393 | No |
| 3990 | 2281 | 1140.5 | 62.2 | 31.1 | Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. | R A Ignotz, J Massague | J Biol Chem | 1986 | 3456347 | Yes |
| 3991 | 4562 | 1140.5 | 108.8 | 27.2 | SCOP: a structural classification of proteins database for the investigation of sequences and structures. | A G Murzin, S E Brenner, T Hubbard, C Chothia | J Mol Biol | 1995 | 7723011 | Yes |
| 3992 | 6842 | 1140.3 | 163.1 | 27.2 | Alpha-synuclein in Lewy bodies. | M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M Goedert | Nature | 1997 | 9278044 | Yes |
| 3993 | 2280 | 1140.0 | 65.1 | 32.5 | Flexible regression models with cubic splines. | S Durrleman, R Simon | Stat Med | 1989 | 2657958 | Yes |
| 3994 | 1140 | 1140.0 | 25.1 | 25.1 | Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. | M Kozak | Nucleic Acids Res | 1981 | 7301588 | Yes |
| 3995 | 1140 | 1140.0 | 0.0 | 0.0 | Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. | R J Pennington | Biochem J | 1961 | 13734134 | Yes |
| 3996 | 1140 | 1140.0 | 23.0 | 23.0 | Inferences, questions and possibilities in Toll-like receptor signalling. | Bruce Beutler | Nature | 2004 | 15241424 | No |
| 3997 | 1140 | 1140.0 | 33.5 | 33.5 | Micellar nanocarriers: pharmaceutical perspectives. | V P Torchilin | Pharm Res | 2007 | 17109211 | No |
| 3998 | 1140 | 1140.0 | 35.1 | 35.1 | Cytochrome p450 and chemical toxicology. | F Peter Guengerich | Chem Res Toxicol | 2008 | 18052394 | No |
| 3999 | 2279 | 1139.5 | 74.0 | 37.0 | A rating scale for extrapyramidal side effects. | G M Simpson, J W Angus | Acta Psychiatr Scand Suppl | 1970 | 4917967 | Yes |
| 4000 | 2278 | 1139.0 | 63.5 | 31.8 | Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. | D Rice, S Barone | Environ Health Perspect | 2000 | 10852851 | No |
| 4001 | 2278 | 1139.0 | 52.0 | 26.0 | InterProScan--an integration platform for the signature-recognition methods in InterPro. | E M Zdobnov, R Apweiler | Bioinformatics | 2001 | 11590104 | Yes |
| 4002 | 1139 | 1139.0 | 22.1 | 22.1 | Focal adhesion kinase: the first ten years. | J Thomas Parsons | J Cell Sci | 2003 | 12640026 | No |
| 4003 | 2277 | 1138.5 | 66.1 | 33.0 | The cerebellar cognitive affective syndrome. | J D Schmahmann, J C Sherman | Brain | 1998 | 9577385 | Yes |
| 4004 | 1138 | 1138.0 | 15.5 | 15.5 | Cell lines derived from late embryonic stages of Drosophila melanogaster. | I Schneider | J Embryol Exp Morphol | 1972 | 4625067 | Yes |
| 4005 | 1138 | 1138.0 | 34.4 | 34.4 | Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. | M J Gasson | J Bacteriol | 1983 | 6403500 | Yes |
| 4006 | 2276 | 1138.0 | 95.0 | 47.5 | The structure of psychological well-being revisited. | C D Ryff, C L Keyes | J Pers Soc Psychol | 1995 | 7473027 | Yes |
| 4007 | 1138 | 1138.0 | 40.6 | 40.6 | Perceptual load as a necessary condition for selective attention. | N Lavie | J Exp Psychol Hum Percept Perform | 1995 | 7790827 | Yes |
| 4008 | 1138 | 1138.0 | 0.0 | 0.0 | The effect of emotion on cue utilization and the organization of behavior. | J A Easterbrook | Psychol Rev | 1959 | 13658305 | Yes |
| 4009 | 1138 | 1138.0 | 0.0 | 0.0 | On the prediction of occurrence of particular verbal intrusions in immediate recall. | J Deese | J Exp Psychol | 1959 | 13664879 | Yes |
| 4010 | 1138 | 1138.0 | 22.6 | 22.6 | The evolutionary significance of cis-regulatory mutations. | Gregory A Wray | Nat Rev Genet | 2007 | 17304246 | No |
| 4011 | 1138 | 1138.0 | 59.7 | 59.7 | Mitochondrial Dynamics and Its Involvement in Disease. | David C Chan | Annu Rev Pathol | 2020 | 31585519 | No |
| 4012 | 2275 | 1137.5 | 58.6 | 29.3 | Inflammatory bowel disease. | Clara Abraham, Judy H Cho | N Engl J Med | 2009 | 19923578 | No |
| 4013 | 1137 | 1137.0 | 36.2 | 36.2 | Protein damage and degradation by oxygen radicals. I. general aspects. | K J Davies | J Biol Chem | 1987 | 3036875 | Yes |
| 4014 | 1137 | 1137.0 | 22.5 | 22.5 | Mechanisms and consequences of activation of protein kinase B/Akt. | J Downward | Curr Opin Cell Biol | 1998 | 9561851 | No |
| 4015 | 1137 | 1137.0 | 29.9 | 29.9 | Anti-inflammatory actions of glucocorticoids: molecular mechanisms. | P J Barnes | Clin Sci (Lond) | 1998 | 9854452 | No |
| 4016 | 1137 | 1137.0 | 24.8 | 24.8 | The muscular dystrophies. | Alan E H Emery | Lancet | 2002 | 11879882 | No |
| 4017 | 1137 | 1137.0 | 39.5 | 39.5 | The Delphi technique: myths and realities. | Catherine Powell | J Adv Nurs | 2003 | 12581103 | No |
| 4018 | 2273 | 1136.5 | 42.5 | 21.2 | T antigen is bound to a host protein in SV40-transformed cells. | D P Lane, L V Crawford | Nature | 1979 | 218111 | Yes |
| 4019 | 2273 | 1136.5 | 96.1 | 48.0 | Global estimates of visual impairment: 2010. | Donatella Pascolini, Silvio Paolo Mariotti | Br J Ophthalmol | 2012 | 22133988 | Yes |
| 4020 | 1136 | 1136.0 | 36.5 | 36.5 | Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. | J E Oesterling | J Urol | 1991 | 1707989 | No |
| 4021 | 2272 | 1136.0 | 46.9 | 23.4 | A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. | N C Andrews, D V Faller | Nucleic Acids Res | 1991 | 2041787 | Yes |
| 4022 | 1136 | 1136.0 | 37.1 | 37.1 | Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. | W A Catterall | Annu Rev Pharmacol Toxicol | 1980 | 6247957 | No |
| 4023 | 1136 | 1136.0 | 37.2 | 37.2 | Food reward: brain substrates of wanting and liking. | K C Berridge | Neurosci Biobehav Rev | 1996 | 8622814 | No |
| 4024 | 1136 | 1136.0 | 39.3 | 39.3 | Spontaneous dissection of the carotid and vertebral arteries. | W I Schievink | N Engl J Med | 2001 | 11259724 | No |
| 4025 | 1136 | 1136.0 | 26.6 | 26.6 | New ideas about atrial fibrillation 50 years on. | Stanley Nattel | Nature | 2002 | 11805846 | No |
| 4026 | 1136 | 1136.0 | 31.6 | 31.6 | Impact of 16S rRNA gene sequence analysis for identification of bacteria on clinical microbiology and infectious diseases. | Jill E Clarridge | Clin Microbiol Rev | 2004 | 15489351 | No |
| 4027 | 2272 | 1136.0 | 56.3 | 28.1 | CpG islands and the regulation of transcription. | Aimee M Deaton, Adrian Bird | Genes Dev | 2011 | 21576262 | No |
| 4028 | 6816 | 1136.0 | 224.2 | 37.4 | Open Babel: An open chemical toolbox. | Noel M O'Boyle, Michael Banck, Craig A James, Chris Morley, Tim Vandermeersch, Geoffrey R Hutchison | J Cheminform | 2011 | 21982300 | Yes |
| 4029 | 2271 | 1135.5 | 62.6 | 31.3 | Adjusting for multiple testing--when and how? | R Bender, S Lange | J Clin Epidemiol | 2001 | 11297884 | No |
| 4030 | 1135 | 1135.0 | 0.0 | 0.0 | pA, a new scale for the measurement of drug antagonism. | H O Schild | Br J Pharmacol Chemother | 1947 | 20258355 | Yes |
| 4031 | 2269 | 1134.5 | 74.2 | 37.1 | Severe psoriasis--oral therapy with a new retinoid. | T Fredriksson, U Pettersson | Dermatologica | 1978 | 357213 | Yes |
| 4032 | 1134 | 1134.0 | 55.0 | 55.0 | Cytoprotection by prostaglandins. | A Robert | Gastroenterology | 1979 | 38173 | Yes |
| 4033 | 3402 | 1134.0 | 129.8 | 43.3 | Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. | P S Walsh, D A Metzger, R Higuchi | Biotechniques | 1991 | 1867860 | Yes |
| 4034 | 1134 | 1134.0 | 0.0 | 0.0 | Why people use health services. | I M Rosenstock | Milbank Mem Fund Q | 1966 | 5967464 | Yes |
| 4035 | 1134 | 1134.0 | 31.3 | 31.3 | Biological effects of resveratrol. | L Fremont | Life Sci | 2000 | 10680575 | No |
| 4036 | 1134 | 1134.0 | 24.8 | 24.8 | Large-scale recording of neuronal ensembles. | Gyorgy Buzsaki | Nat Neurosci | 2004 | 15114356 | No |
| 4037 | 2267 | 1133.5 | 53.5 | 26.8 | How to interpret LC3 immunoblotting. | Noboru Mizushima, Tamotsu Yoshimori | Autophagy | 2007 | 17611390 | No |
| 4038 | 3400 | 1133.3 | 90.9 | 30.3 | Cytochemical identification of monocytes and granulocytes. | L T Yam, C Y Li, W H Crosby | Am J Clin Pathol | 1971 | 5549896 | Yes |
| 4039 | 1133 | 1133.0 | 43.8 | 43.8 | Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. | J N Wasserheit | Sex Transm Dis | 1992 | 1595015 | No |
| 4040 | 1133 | 1133.0 | 23.4 | 23.4 | Automated NMR structure calculation with CYANA. | Peter Guntert | Methods Mol Biol | 2004 | 15318003 | Yes |
| 4041 | 1133 | 1133.0 | 25.3 | 25.3 | The molecular biology of coronaviruses. | Paul S Masters | Adv Virus Res | 2006 | 16877062 | No |
| 4042 | 1132 | 1132.0 | 24.3 | 24.3 | Mutator phenotype may be required for multistage carcinogenesis. | L A Loeb | Cancer Res | 1991 | 2039987 | No |
| 4043 | 1132 | 1132.0 | 21.9 | 21.9 | Contingent genetic regulatory events in T lymphocyte activation. | G R Crabtree | Science | 1989 | 2783497 | Yes |
| 4044 | 1132 | 1132.0 | 36.1 | 36.1 | Tests for emotionality in rats and mice: a review. | J Archer | Anim Behav | 1973 | 4578750 | No |
| 4045 | 1132 | 1132.0 | 36.5 | 36.5 | Image matching as a diffusion process: an analogy with Maxwell's demons. | J P Thirion | Med Image Anal | 1998 | 9873902 | Yes |
| 4046 | 1132 | 1132.0 | 0.0 | 0.0 | Neural basis of the spontaneous optokinetic response produced by visual inversion. | R W Sperry | J Comp Physiol Psychol | 1950 | 14794830 | Yes |
| 4047 | 2264 | 1132.0 | 64.0 | 32.0 | The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. | Alicia A Walf, Cheryl A Frye | Nat Protoc | 2007 | 17406592 | Yes |
| 4048 | 3395 | 1131.7 | 135.9 | 45.3 | Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA approved pharmaceuticals. | Edon Vitaku, David T Smith, Jon T Njardarson | J Med Chem | 2014 | 25255204 | No |
| 4049 | 2263 | 1131.5 | 47.1 | 23.6 | RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. | M B Shapiro, P Senapathy | Nucleic Acids Res | 1987 | 3658675 | Yes |
| 4050 | 2263 | 1131.5 | 68.6 | 34.3 | Systematic optimization of long-range corrected hybrid density functionals. | Jeng-Da Chai, Martin Head-Gordon | J Chem Phys | 2008 | 18315032 | Yes |
| 4051 | 2263 | 1131.5 | 111.4 | 55.7 | Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. | Justin M Long, David M Holtzman | Cell | 2019 | 31564456 | No |
| 4052 | 3394 | 1131.3 | 141.6 | 47.2 | A new method for detecting anaerobic threshold by gas exchange. | W L Beaver, K Wasserman, B J Whipp | J Appl Physiol (1985) | 1986 | 3087938 | Yes |
| 4053 | 1131 | 1131.0 | 62.3 | 62.3 | The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. | J A Koufman | Laryngoscope | 1991 | 1895864 | No |
| 4054 | 1131 | 1131.0 | 40.6 | 40.6 | Sex-hormone-binding globulin. | D C Anderson | Clin Endocrinol (Oxf) | 1974 | 4134992 | No |
| 4055 | 1131 | 1131.0 | 40.1 | 40.1 | On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. | D Collen | Thromb Haemost | 1980 | 6450468 | No |
| 4056 | 1131 | 1131.0 | 21.5 | 21.5 | Chronic myeloid leukemia. | C L Sawyers | N Engl J Med | 1999 | 10219069 | No |
| 4057 | 1131 | 1131.0 | 34.9 | 34.9 | Inhibition of return. | R M Klein | Trends Cogn Sci | 2000 | 10740278 | Yes |
| 4058 | 1131 | 1131.0 | 25.4 | 25.4 | The self-tuning neuron: synaptic scaling of excitatory synapses. | Gina G Turrigiano | Cell | 2008 | 18984155 | No |
| 4059 | 1131 | 1131.0 | 25.2 | 25.2 | Evolution of the neocortex: a perspective from developmental biology. | Pasko Rakic | Nat Rev Neurosci | 2009 | 19763105 | No |
| 4060 | 4522 | 1130.5 | 163.9 | 41.0 | A basic introduction to fixed-effect and random-effects models for meta-analysis. | Michael Borenstein, Larry V Hedges, Julian P T Higgins, Hannah R Rothstein | Res Synth Methods | 2010 | 26061376 | Yes |
| 4061 | 1130 | 1130.0 | 40.3 | 40.3 | Why we need observational studies to evaluate the effectiveness of health care. | N Black | BMJ | 1996 | 8634569 | Yes |
| 4062 | 1130 | 1130.0 | 24.5 | 24.5 | Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. | Z Yang | Mol Biol Evol | 1998 | 9580986 | Yes |
| 4063 | 1130 | 1130.0 | 30.1 | 30.1 | Forests and climate change: forcings, feedbacks, and the climate benefits of forests. | Gordon B Bonan | Science | 2008 | 18556546 | No |
| 4064 | 1130 | 1130.0 | 34.6 | 34.6 | α-Synuclein in Parkinson's disease. | Leonidas Stefanis | Cold Spring Harb Perspect Med | 2012 | 22355802 | No |
| 4065 | 2260 | 1130.0 | 75.4 | 37.7 | The economy of brain network organization. | Ed Bullmore, Olaf Sporns | Nat Rev Neurosci | 2012 | 22498897 | No |
| 4066 | 1130 | 1130.0 | 38.8 | 38.8 | Measures of Diagnostic Accuracy: Basic Definitions. | Ana-Maria Simundic | EJIFCC | 2009 | 27683318 | Yes |
| 4067 | 2259 | 1129.5 | 50.1 | 25.1 | Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. | P J Roberts, C J Der | Oncogene | 2007 | 17496923 | No |
| 4068 | 1129 | 1129.0 | 51.5 | 51.5 | Movement, posture and equilibrium: interaction and coordination. | J Massion | Prog Neurobiol | 1992 | 1736324 | No |
| 4069 | 1129 | 1129.0 | 29.3 | 29.3 | Linkage strategies for genetically complex traits. I. Multilocus models. | N Risch | Am J Hum Genet | 1990 | 2301392 | Yes |
| 4070 | 1129 | 1129.0 | 31.3 | 31.3 | Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. | M M Weiser | J Biol Chem | 1973 | 4698230 | Yes |
| 4071 | 1129 | 1129.0 | 23.4 | 23.4 | Unfolding the role of protein misfolding in neurodegenerative diseases. | Claudio Soto | Nat Rev Neurosci | 2003 | 12511861 | No |
| 4072 | 1129 | 1129.0 | 31.5 | 31.5 | Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. | Paul H Yancey | J Exp Biol | 2005 | 16043587 | No |
| 4073 | 1129 | 1129.0 | 38.4 | 38.4 | Vitamin D status: measurement, interpretation, and clinical application. | Michael F Holick | Ann Epidemiol | 2009 | 18329892 | No |
| 4074 | 2258 | 1129.0 | 59.1 | 29.6 | Recent developments in the MAFFT multiple sequence alignment program. | Kazutaka Katoh, Hiroyuki Toh | Brief Bioinform | 2008 | 18372315 | Yes |
| 4075 | 2258 | 1129.0 | 55.4 | 27.7 | Clonal evolution in cancer. | Mel Greaves, Carlo C Maley | Nature | 2012 | 22258609 | No |
| 4076 | 2257 | 1128.5 | 0.0 | 0.0 | Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. | L M Siegel, K J Monty | Biochim Biophys Acta | 1966 | 5329026 | Yes |
| 4077 | 2257 | 1128.5 | 71.0 | 35.5 | The human microbiome: at the interface of health and disease. | Ilseung Cho, Martin J Blaser | Nat Rev Genet | 2012 | 22411464 | No |
| 4078 | 1128 | 1128.0 | 32.0 | 32.0 | Transport of molecules in the tumor interstitium: a review. | R K Jain | Cancer Res | 1987 | 3555767 | No |
| 4079 | 1128 | 1128.0 | 27.8 | 27.8 | Cells in stress: transcriptional activation of heat shock genes. | R I Morimoto | Science | 1993 | 8451637 | No |
| 4080 | 1128 | 1128.0 | 25.6 | 25.6 | Complement. Second of two parts. | M J Walport | N Engl J Med | 2001 | 11297706 | No |
| 4081 | 1128 | 1128.0 | 0.0 | 0.0 | Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. | A B Stavitsky | J Immunol | 1954 | 13163409 | Yes |
| 4082 | 1128 | 1128.0 | 36.0 | 36.0 | Molecular pathogenesis and mechanisms of thyroid cancer. | Mingzhao Xing | Nat Rev Cancer | 2013 | 23429735 | No |
| 4083 | 5640 | 1128.0 | 321.7 | 64.3 | Posterior Summarization in Bayesian Phylogenetics Using Tracer 1.7. | Andrew Rambaut, Alexei J Drummond, Dong Xie, Guy Baele, Marc A Suchard | Syst Biol | 2018 | 29718447 | Yes |
| 4084 | 6767 | 1127.8 | 619.7 | 103.3 | ColabFold: making protein folding accessible to all. | Milot Mirdita, Konstantin Schutze, Yoshitaka Moriwaki, Lim Heo, Sergey Ovchinnikov, Martin Steinegger | Nat Methods | 2022 | 35637307 | Yes |
| 4085 | 3383 | 1127.7 | 115.5 | 38.5 | A new rating scale for Alzheimer's disease. | W G Rosen, R C Mohs, K L Davis | Am J Psychiatry | 1984 | 6496779 | Yes |
| 4086 | 1127 | 1127.0 | 29.0 | 29.0 | The Trk family of neurotrophin receptors. | M Barbacid | J Neurobiol | 1994 | 7852993 | No |
| 4087 | 1127 | 1127.0 | 23.0 | 23.0 | Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. | A S Baldwin | J Clin Invest | 2001 | 11160144 | No |
| 4088 | 1127 | 1127.0 | 27.1 | 27.1 | Current concepts of the pathogenesis of the acute coronary syndromes. | P Libby | Circulation | 2001 | 11457759 | No |
| 4089 | 1127 | 1127.0 | 28.5 | 28.5 | P-450 metabolites of arachidonic acid in the control of cardiovascular function. | Richard J Roman | Physiol Rev | 2002 | 11773611 | No |
| 4090 | 2254 | 1127.0 | 66.5 | 33.2 | How should meta-regression analyses be undertaken and interpreted? | Simon G Thompson, Julian P T Higgins | Stat Med | 2002 | 12111920 | Yes |
| 4091 | 1127 | 1127.0 | 19.3 | 19.3 | Molecular mechanisms of axon guidance. | Barry J Dickson | Science | 2002 | 12471249 | No |
| 4092 | 1127 | 1127.0 | 40.2 | 40.2 | Chemistry and biochemistry of dietary polyphenols. | Rong Tsao | Nutrients | 2010 | 22254006 | No |
| 4093 | 2253 | 1126.5 | 53.6 | 26.8 | Mechanisms of endocytosis. | Gary J Doherty, Harvey T McMahon | Annu Rev Biochem | 2009 | 19317650 | No |
| 4094 | 1126 | 1126.0 | 51.8 | 51.8 | The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. | J Cassel | Am J Epidemiol | 1976 | 782233 | No |
| 4095 | 1126 | 1126.0 | 36.8 | 36.8 | Microbial heavy-metal resistance. | D H Nies | Appl Microbiol Biotechnol | 1999 | 10422221 | No |
| 4096 | 1126 | 1126.0 | 26.8 | 26.8 | A cortical-hippocampal system for declarative memory. | H Eichenbaum | Nat Rev Neurosci | 2000 | 11252767 | No |
| 4097 | 1126 | 1126.0 | 58.6 | 58.6 | Why is depression more common among women than among men? | Christine Kuehner | Lancet Psychiatry | 2017 | 27856392 | No |
| 4098 | 1125 | 1125.0 | 20.4 | 20.4 | The evolutionary advantage of recombination. | J Felsenstein | Genetics | 1974 | 4448362 | Yes |
| 4099 | 2250 | 1125.0 | 58.7 | 29.4 | Breast cancer and hormone-replacement therapy in the Million Women Study. | Valerie Beral, | Lancet | 2003 | 12927427 | Yes |
| 4100 | 1125 | 1125.0 | 29.9 | 29.9 | Sleep-dependent memory consolidation. | Robert Stickgold | Nature | 2005 | 16251952 | No |
| 4101 | 2249 | 1124.5 | 66.0 | 33.0 | A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. | J J Sedmak, S E Grossberg | Anal Biochem | 1977 | 68686 | Yes |
| 4102 | 2249 | 1124.5 | 114.6 | 57.3 | Optimism, coping, and health: assessment and implications of generalized outcome expectancies. | M F Scheier, C S Carver | Health Psychol | 1985 | 4029106 | Yes |
| 4103 | 2249 | 1124.5 | 97.2 | 48.6 | Development of primer sets designed for use with the PCR to amplify conserved genes from filamentous ascomycetes. | N L Glass, G C Donaldson | Appl Environ Microbiol | 1995 | 7747954 | Yes |
| 4104 | 2249 | 1124.5 | 67.7 | 33.9 | Chronic hepatitis B: update 2009. | Anna S F Lok, Brian J McMahon | Hepatology | 2009 | 19714720 | Yes |
| 4105 | 2249 | 1124.5 | 71.6 | 35.8 | Exploring the brain network: a review on resting-state fMRI functional connectivity. | Martijn P Van Den Heuvel, Hilleke E Hulshoff Pol | Eur Neuropsychopharmacol | 2010 | 20471808 | No |
| 4106 | 1124 | 1124.0 | 56.7 | 56.7 | Psychophysical scaling with applications in physical work and the perception of exertion. | G Borg | Scand J Work Environ Health | 1990 | 2345867 | Yes |
| 4107 | 1124 | 1124.0 | 34.1 | 34.1 | Cell surface interactions with extracellular materials. | K M Yamada | Annu Rev Biochem | 1983 | 6351729 | No |
| 4108 | 2248 | 1124.0 | 50.3 | 25.1 | Prediction of protein secondary structure at better than 70% accuracy. | B Rost, C Sander | J Mol Biol | 1993 | 8345525 | Yes |
| 4109 | 1124 | 1124.0 | 37.4 | 37.4 | Designing cell-compatible hydrogels for biomedical applications. | Dror Seliktar | Science | 2012 | 22654050 | No |
| 4110 | 4495 | 1123.8 | 134.6 | 33.6 | Prevalence and trends in obesity among US adults, 1999-2000. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L Johnson | JAMA | 2002 | 12365955 | Yes |
| 4111 | 2247 | 1123.5 | 0.0 | 0.0 | Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. | P Gold, S O Freedman | J Exp Med | 1965 | 14270243 | Yes |
| 4112 | 1123 | 1123.0 | 0.0 | 0.0 | Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. | A R Midgley | Endocrinology | 1966 | 5950482 | Yes |
| 4113 | 1123 | 1123.0 | 22.2 | 22.2 | Regulation of transcription by MAP kinase cascades. | R Treisman | Curr Opin Cell Biol | 1996 | 8791420 | No |
| 4114 | 1123 | 1123.0 | 0.0 | 0.0 | A cytoarchitectonic atlas of the spinal cord in the cat. | B Rexed | J Comp Neurol | 1954 | 13163236 | Yes |
| 4115 | 2246 | 1123.0 | 66.5 | 33.2 | The spread of obesity in a large social network over 32 years. | Nicholas A Christakis, James H Fowler | N Engl J Med | 2007 | 17652652 | Yes |
| 4116 | 1123 | 1123.0 | 0.0 | 0.0 | Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. | R D Owen | Science | 1945 | 17755278 | Yes |
| 4117 | 3369 | 1123.0 | 164.7 | 54.9 | miRBase: from microRNA sequences to function. | Ana Kozomara, Maria Birgaoanu, Sam Griffiths-Jones | Nucleic Acids Res | 2019 | 30423142 | Yes |
| 4118 | 4491 | 1122.8 | 146.6 | 36.6 | Biomolecular condensates: organizers of cellular biochemistry. | Salman F Banani, Hyun O Lee, Anthony A Hyman, Michael K Rosen | Nat Rev Mol Cell Biol | 2017 | 28225081 | No |
| 4119 | 4490 | 1122.5 | 134.6 | 33.6 | PACKMOL: a package for building initial configurations for molecular dynamics simulations. | L Martinez, R Andrade, E G Birgin, J M Martinez | J Comput Chem | 2009 | 19229944 | Yes |
| 4120 | 2245 | 1122.5 | 51.9 | 25.9 | p21 in cancer: intricate networks and multiple activities. | Tarek Abbas, Anindya Dutta | Nat Rev Cancer | 2009 | 19440234 | No |
| 4121 | 4489 | 1122.2 | 156.3 | 39.1 | Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. | S Pellow, P Chopin, S E File, M Briley | J Neurosci Methods | 1985 | 2864480 | Yes |
| 4122 | 1122 | 1122.0 | 40.8 | 40.8 | Lipid peroxidation and antioxidants as biomarkers of tissue damage. | J M Gutteridge | Clin Chem | 1995 | 7497639 | No |
| 4123 | 2244 | 1122.0 | 92.8 | 46.4 | Implementation matters: a review of research on the influence of implementation on program outcomes and the factors affecting implementation. | Joseph A Durlak, Emily P DuPre | Am J Community Psychol | 2008 | 18322790 | No |
| 4124 | 2243 | 1121.5 | 55.4 | 27.7 | The regulation and function of c-fos and other immediate early genes in the nervous system. | M Sheng, M E Greenberg | Neuron | 1990 | 1969743 | No |
| 4125 | 1121 | 1121.0 | 49.4 | 49.4 | Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. | S Z Langer | Br J Pharmacol | 1977 | 20190 | No |
| 4126 | 1121 | 1121.0 | 38.6 | 38.6 | Chemoprevention of cancer. | L W Wattenberg | Cancer Res | 1985 | 3880665 | No |
| 4127 | 1121 | 1121.0 | 23.9 | 23.9 | ALSCRIPT: a tool to format multiple sequence alignments. | G J Barton | Protein Eng | 1993 | 8433969 | Yes |
| 4128 | 1121 | 1121.0 | 22.1 | 22.1 | mTOR and cancer: insights into a complex relationship. | David M Sabatini | Nat Rev Cancer | 2006 | 16915295 | No |
| 4129 | 4484 | 1121.0 | 152.7 | 38.2 | Prevalence and trends in obesity among US adults, 1999-2008. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R Curtin | JAMA | 2010 | 20071471 | Yes |
| 4130 | 1121 | 1121.0 | 57.3 | 57.3 | The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state. | Ergul Belge Kurutas | Nutr J | 2016 | 27456681 | No |
| 4131 | 1120 | 1120.0 | 29.8 | 29.8 | Neuropathology of Parkinson's disease. | L S Forno | J Neuropathol Exp Neurol | 1996 | 8786384 | No |
| 4132 | 1120 | 1120.0 | 21.6 | 21.6 | Cytokines in cancer pathogenesis and cancer therapy. | Glenn Dranoff | Nat Rev Cancer | 2004 | 14708024 | No |
| 4133 | 1120 | 1120.0 | 33.8 | 33.8 | Lanthanide-based luminescent hybrid materials. | Koen Binnemans | Chem Rev | 2009 | 19650663 | Yes |
| 4134 | 2240 | 1120.0 | 77.9 | 39.0 | Plant polyphenols as dietary antioxidants in human health and disease. | Kanti Bhooshan Pandey, Syed Ibrahim Rizvi | Oxid Med Cell Longev | 2009 | 20716914 | No |
| 4135 | 2239 | 1119.5 | 0.0 | 0.0 | Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. | R J Britten, D E Kohne | Science | 1968 | 4874239 | Yes |
| 4136 | 11191 | 1119.1 | 460.8 | 46.1 | QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. | Penny F Whiting, Anne W S Rutjes, Marie E Westwood, Susan Mallett, Jonathan J Deeks, Johannes B Reitsma, Mariska M G Leeflang, Jonathan A C Sterne, Patrick M M Bossuyt, | Ann Intern Med | 2011 | 22007046 | Yes |
| 4137 | 1119 | 1119.0 | 34.9 | 34.9 | Comparing evolvability and variability of quantitative traits. | D Houle | Genetics | 1992 | 1732160 | Yes |
| 4138 | 1119 | 1119.0 | 40.6 | 40.6 | A theory of visual attention. | C Bundesen | Psychol Rev | 1990 | 2247540 | Yes |
| 4139 | 1119 | 1119.0 | 30.3 | 30.3 | The chromosomal basis of human neoplasia. | J J Yunis | Science | 1983 | 6336310 | Yes |
| 4140 | 1119 | 1119.0 | 29.6 | 29.6 | Trypan blue exclusion test of cell viability. | W Strober | Curr Protoc Immunol | 2001 | 18432654 | Yes |
| 4141 | 4475 | 1118.8 | 122.4 | 30.6 | An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. | Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H Burdette | Neuroimage | 2003 | 12880848 | Yes |
| 4142 | 4474 | 1118.5 | 120.7 | 30.2 | A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. | I Vermes, C Haanen, H Steffens-Nakken, C Reutelingsperger | J Immunol Methods | 1995 | 7622868 | Yes |
| 4143 | 2237 | 1118.5 | 76.6 | 38.3 | The Li-ion rechargeable battery: a perspective. | John B Goodenough, Kyu-Sung Park | J Am Chem Soc | 2013 | 23294028 | Yes |
| 4144 | 2237 | 1118.5 | 72.6 | 36.3 | PARP inhibitors: Synthetic lethality in the clinic. | Christopher J Lord, Alan Ashworth | Science | 2017 | 28302823 | No |
| 4145 | 14538 | 1118.3 | 435.3 | 33.5 | The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. | Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella, , | JAMA | 2003 | 12748199 | No |
| 4146 | 1118 | 1118.0 | 27.4 | 27.4 | The primate basal ganglia: parallel and integrative networks. | Suzanne N Haber | J Chem Neuroanat | 2003 | 14729134 | No |
| 4147 | 3354 | 1118.0 | 118.5 | 39.5 | The triple aim: care, health, and cost. | Donald M Berwick, Thomas W Nolan, John Whittington | Health Aff (Millwood) | 2008 | 18474969 | Yes |
| 4148 | 3353 | 1117.7 | 89.2 | 29.7 | Stress and the brain: from adaptation to disease. | E Ron De Kloet, Marian Joels, Florian Holsboer | Nat Rev Neurosci | 2005 | 15891777 | No |
| 4149 | 2235 | 1117.5 | 0.0 | 0.0 | Microdroplet Assay Of Human Serum Cytotoxins. | P I Terasaki, J D McClelland | Nature | 1964 | 14248725 | Yes |
| 4150 | 2235 | 1117.5 | 54.3 | 27.1 | Antiinflammatory action of glucocorticoids--new mechanisms for old drugs. | Turk Rhen, John A Cidlowski | N Engl J Med | 2005 | 16236742 | No |
| 4151 | 2235 | 1117.5 | 82.2 | 41.1 | Coronaviruses: an overview of their replication and pathogenesis. | Anthony R Fehr, Stanley Perlman | Methods Mol Biol | 2015 | 25720466 | No |
| 4152 | 1117 | 1117.0 | 23.2 | 23.2 | mRNA stability in mammalian cells. | J Ross | Microbiol Rev | 1995 | 7565413 | No |
| 4153 | 4468 | 1117.0 | 178.9 | 44.7 | Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. | K F Schulz, I Chalmers, R J Hayes, D G Altman | JAMA | 1995 | 7823387 | Yes |
| 4154 | 1117 | 1117.0 | 41.9 | 41.9 | Contaminant-stimulated reactive oxygen species production and oxidative damage in aquatic organisms. | D R Livingstone | Mar Pollut Bull | 2001 | 11525283 | No |
| 4155 | 2234 | 1117.0 | 51.2 | 25.6 | Glycosylation in cellular mechanisms of health and disease. | Kazuaki Ohtsubo, Jamey D Marth | Cell | 2006 | 16959566 | No |
| 4156 | 1117 | 1117.0 | 24.9 | 24.9 | Cells of origin in cancer. | Jane E Visvader | Nature | 2011 | 21248838 | No |
| 4157 | 1117 | 1117.0 | 58.3 | 58.3 | COVID-19: immunopathology and its implications for therapy. | Xuetao Cao | Nat Rev Immunol | 2020 | 32273594 | Yes |
| 4158 | 11169 | 1116.9 | 443.9 | 44.4 | Comprehensive Integration of Single-Cell Data. | Tim Stuart, Andrew Butler, Paul Hoffman, Christoph Hafemeister, Efthymia Papalexi, William M Mauck, Yuhan Hao, Marlon Stoeckius, Peter Smibert, Rahul Satija | Cell | 2019 | 31178118 | Yes |
| 4159 | 5583 | 1116.6 | 154.0 | 30.8 | 10-year follow-up of intensive glucose control in type 2 diabetes. | Rury R Holman, Sanjoy K Paul, M Angelyn Bethel, David R Matthews, H Andrew W Neil | N Engl J Med | 2008 | 18784090 | Yes |
| 4160 | 1116 | 1116.0 | 0.0 | 0.0 | Studies on histones. 7. Preparative methods for histone fractions from calf thymus. | E W Johns | Biochem J | 1964 | 5840387 | Yes |
| 4161 | 4464 | 1116.0 | 113.7 | 28.4 | The epidemiology of sepsis in the United States from 1979 through 2000. | Greg S Martin, David M Mannino, Stephanie Eaton, Marc Moss | N Engl J Med | 2003 | 12700374 | Yes |
| 4162 | 1116 | 1116.0 | 37.8 | 37.8 | The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer. | Donald C McMillan | Cancer Treat Rev | 2013 | 22995477 | No |
| 4163 | 2231 | 1115.5 | 94.7 | 47.4 | Emotional processing of fear: exposure to corrective information. | E B Foa, M J Kozak | Psychol Bull | 1986 | 2871574 | Yes |
| 4164 | 3346 | 1115.3 | 102.7 | 34.2 | Immune checkpoint blockade: a common denominator approach to cancer therapy. | Suzanne L Topalian, Charles G Drake, Drew M Pardoll | Cancer Cell | 2015 | 25858804 | No |
| 4165 | 7806 | 1115.1 | 682.1 | 97.4 | The psychological impact of quarantine and how to reduce it: rapid review of the evidence. | Samantha K Brooks, Rebecca K Webster, Louise E Smith, Lisa Woodland, Simon Wessely, Neil Greenberg, Gideon James Rubin | Lancet | 2020 | 32112714 | No |
| 4166 | 1115 | 1115.0 | 19.3 | 19.3 | The concept of synthetic lethality in the context of anticancer therapy. | William G Kaelin | Nat Rev Cancer | 2005 | 16110319 | No |
| 4167 | 1115 | 1115.0 | 31.8 | 31.8 | Distance-based tests for homogeneity of multivariate dispersions. | Marti J Anderson | Biometrics | 2006 | 16542252 | Yes |
| 4168 | 1115 | 1115.0 | 30.6 | 30.6 | Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. | Satoshi Ikemoto | Brain Res Rev | 2007 | 17574681 | No |
| 4169 | 2229 | 1114.5 | 80.8 | 40.4 | Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. | A I Basbaum, H L Fields | Annu Rev Neurosci | 1984 | 6143527 | No |
| 4170 | 2229 | 1114.5 | 46.0 | 23.0 | MAPK signal pathways in the regulation of cell proliferation in mammalian cells. | Wei Zhang, Hui Tu Liu | Cell Res | 2002 | 11942415 | No |
| 4171 | 4457 | 1114.2 | 111.3 | 27.8 | Permutation tests for joinpoint regression with applications to cancer rates. | H J Kim, M P Fay, E J Feuer, D N Midthune | Stat Med | 2000 | 10649300 | Yes |
| 4172 | 1114 | 1114.0 | 28.7 | 28.7 | Two distinct classes of carbohydrate-recognition domains in animal lectins. | K Drickamer | J Biol Chem | 1988 | 3290208 | No |
| 4173 | 2228 | 1114.0 | 70.7 | 35.4 | Excitatory amino acid transmitters. | J C Watkins, R H Evans | Annu Rev Pharmacol Toxicol | 1981 | 6112965 | No |
| 4174 | 1114 | 1114.0 | 42.6 | 42.6 | Molecular aspects of ligand binding to serum albumin. | U Kragh-Hansen | Pharmacol Rev | 1981 | 7027277 | No |
| 4175 | 2228 | 1114.0 | 48.3 | 24.1 | The Hsp70 and Hsp60 chaperone machines. | B Bukau, A L Horwich | Cell | 1998 | 9476895 | No |
| 4176 | 1114 | 1114.0 | 32.6 | 32.6 | Allostasis and allostatic load: implications for neuropsychopharmacology. | B S McEwen | Neuropsychopharmacology | 2000 | 10649824 | No |
| 4177 | 1114 | 1114.0 | 37.1 | 37.1 | Behavior rating inventory of executive function. | Ida Sue Baron | Child Neuropsychol | 2000 | 11419452 | Yes |
| 4178 | 2228 | 1114.0 | 62.4 | 31.2 | Reactive oxygen species in cancer. | Geou-Yarh Liou, Peter Storz | Free Radic Res | 2010 | 20370557 | No |
| 4179 | 2227 | 1113.5 | 78.2 | 39.1 | Population growth makes waves in the distribution of pairwise genetic differences. | A R Rogers, H Harpending | Mol Biol Evol | 1992 | 1316531 | Yes |
| 4180 | 2227 | 1113.5 | 67.3 | 33.6 | Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. | J M Reul, E R De Kloet | Endocrinology | 1985 | 2998738 | Yes |
| 4181 | 6679 | 1113.2 | 184.5 | 30.8 | Ghrelin is a growth-hormone-releasing acylated peptide from stomach. | M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa | Nature | 1999 | 10604470 | Yes |
| 4182 | 1113 | 1113.0 | 34.0 | 34.0 | The phylogenetic regression. | A Grafen | Philos Trans R Soc Lond B Biol Sci | 1989 | 2575770 | Yes |
| 4183 | 1113 | 1113.0 | 24.2 | 24.2 | A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. | J Milbrandt | Science | 1987 | 3672127 | Yes |
| 4184 | 1113 | 1113.0 | 27.6 | 27.6 | Marine viruses and their biogeochemical and ecological effects. | J A Fuhrman | Nature | 1999 | 10376593 | No |
| 4185 | 1113 | 1113.0 | 35.7 | 35.7 | Investigating neighborhood and area effects on health. | A V Diez Roux | Am J Public Health | 2001 | 11684601 | No |
| 4186 | 1113 | 1113.0 | 26.2 | 26.2 | Immunosuppressive drugs for kidney transplantation. | Philip F Halloran | N Engl J Med | 2004 | 15616206 | No |
| 4187 | 1113 | 1113.0 | 33.8 | 33.8 | On the relationship between emotion and cognition. | Luiz Pessoa | Nat Rev Neurosci | 2008 | 18209732 | No |
| 4188 | 3338 | 1112.7 | 228.6 | 76.2 | Estimating psychological networks and their accuracy: A tutorial paper. | Sacha Epskamp, Denny Borsboom, Eiko I Fried | Behav Res Methods | 2018 | 28342071 | Yes |
| 4189 | 2225 | 1112.5 | 57.0 | 28.5 | ARAGORN, a program to detect tRNA genes and tmRNA genes in nucleotide sequences. | Dean Laslett, Bjorn Canback | Nucleic Acids Res | 2004 | 14704338 | Yes |
| 4190 | 5562 | 1112.4 | 171.5 | 34.3 | Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation. | Gregory Y H Lip, Robby Nieuwlaat, Ron Pisters, Deirdre A Lane, Harry J G M Crijns | Chest | 2010 | 19762550 | Yes |
| 4191 | 1112 | 1112.0 | 26.8 | 26.8 | Selectins and their ligands: current concepts and controversies. | G S Kansas | Blood | 1996 | 8896391 | No |
| 4192 | 2224 | 1112.0 | 39.6 | 19.8 | Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. | W Gu, R G Roeder | Cell | 1997 | 9288740 | Yes |
| 4193 | 2224 | 1112.0 | 62.8 | 31.4 | Frailty in relation to the accumulation of deficits. | Kenneth Rockwood, Arnold Mitnitski | J Gerontol A Biol Sci Med Sci | 2007 | 17634318 | No |
| 4194 | 2224 | 1112.0 | 69.3 | 34.6 | Fiber types in mammalian skeletal muscles. | Stefano Schiaffino, Carlo Reggiani | Physiol Rev | 2011 | 22013216 | No |
| 4195 | 2224 | 1112.0 | 97.5 | 48.8 | EMT Transition States during Tumor Progression and Metastasis. | Ievgenia Pastushenko, Cedric Blanpain | Trends Cell Biol | 2019 | 30594349 | No |
| 4196 | 3335 | 1111.7 | 70.0 | 23.3 | X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. | Robert L Camp, Marisa Dolled-Filhart, David L Rimm | Clin Cancer Res | 2004 | 15534099 | Yes |
| 4197 | 2222 | 1111.0 | 44.6 | 22.3 | In search of the 'missing self': MHC molecules and NK cell recognition. | H G Ljunggren, K Karre | Immunol Today | 1990 | 2201309 | No |
| 4198 | 1111 | 1111.0 | 31.9 | 31.9 | Aging, energy, and oxidative stress in neurodegenerative diseases. | M F Beal | Ann Neurol | 1995 | 7668820 | No |
| 4199 | 1111 | 1111.0 | 0.0 | 0.0 | Asymptomatic infections of the urinary tract. | E H Kass | Trans Assoc Am Physicians | 1956 | 13380946 | Yes |
| 4200 | 1111 | 1111.0 | 38.3 | 38.3 | A novel automated method to measure total antioxidant response against potent free radical reactions. | Ozcan Erel | Clin Biochem | 2004 | 14725941 | Yes |
| 4201 | 1111 | 1111.0 | 30.6 | 30.6 | Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate. | Randy L Buckner | Neuron | 2004 | 15450170 | No |
| 4202 | 1111 | 1111.0 | 30.8 | 30.8 | The developmental origins of adult disease. | D J P Barker | J Am Coll Nutr | 2004 | 15640511 | No |
| 4203 | 2222 | 1111.0 | 45.8 | 22.9 | Phosphoinositides in cell regulation and membrane dynamics. | Gilbert Di Paolo, Pietro De Camilli | Nature | 2006 | 17035995 | No |
| 4204 | 1111 | 1111.0 | 28.3 | 28.3 | Papillomaviruses in the causation of human cancers - a brief historical account. | Harald Zur Hausen | Virology | 2009 | 19135222 | No |
| 4205 | 2222 | 1111.0 | 61.4 | 30.7 | Delivering nanomedicine to solid tumors. | Rakesh K Jain, Triantafyllos Stylianopoulos | Nat Rev Clin Oncol | 2010 | 20838415 | No |
| 4206 | 1111 | 1111.0 | 31.5 | 31.5 | Neuronal circuitry for pain processing in the dorsal horn. | Andrew J Todd | Nat Rev Neurosci | 2010 | 21068766 | No |
| 4207 | 1111 | 1111.0 | 37.5 | 37.5 | Isolation By Distance In Equilibrium And Non-Equilibrium Populations. | Montgomery Slatkin | Evolution | 1993 | 28568097 | Yes |
| 4208 | 2222 | 1111.0 | 106.3 | 53.1 | The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications. | Yuanyuan Zhang, Zemin Zhang | Cell Mol Immunol | 2020 | 32612154 | No |
| 4209 | 2221 | 1110.5 | 69.0 | 34.5 | Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. | C N Hales, D J Barker | Diabetologia | 1992 | 1644236 | No |
| 4210 | 3330 | 1110.0 | 108.0 | 36.0 | Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. | M Hamberg, J Svensson, B Samuelsson | Proc Natl Acad Sci U S A | 1975 | 1059088 | Yes |
| 4211 | 1110 | 1110.0 | 0.0 | 0.0 | A kinetic photometric method for serum gamma-glutamyl transpeptidase. | G Szasz | Clin Chem | 1969 | 5773262 | Yes |
| 4212 | 1110 | 1110.0 | 27.3 | 27.3 | Biochemistry and genetics of von Willebrand factor. | J E Sadler | Annu Rev Biochem | 1998 | 9759493 | No |
| 4213 | 1110 | 1110.0 | 25.2 | 25.2 | Ligand-targeted therapeutics in anticancer therapy. | Theresa M Allen | Nat Rev Cancer | 2002 | 12360278 | No |
| 4214 | 1110 | 1110.0 | 0.0 | 0.0 | Some informational aspects of visual perception. | F Attneave | Psychol Rev | 1954 | 13167245 | Yes |
| 4215 | 2220 | 1110.0 | 48.8 | 24.4 | Drug repositioning: identifying and developing new uses for existing drugs. | Ted T Ashburn, Karl B Thor | Nat Rev Drug Discov | 2004 | 15286734 | No |
| 4216 | 1110 | 1110.0 | 27.1 | 27.1 | Cooling, heating, generating power, and recovering waste heat with thermoelectric systems. | Lon E Bell | Science | 2008 | 18787160 | Yes |
| 4217 | 3330 | 1110.0 | 98.1 | 32.7 | Electrical energy storage for the grid: a battery of choices. | Bruce Dunn, Haresh Kamath, Jean-Marie Tarascon | Science | 2011 | 22096188 | Yes |
| 4218 | 2219 | 1109.5 | 108.6 | 54.3 | Development, reliability, and validity of a dissociation scale. | E M Bernstein, F W Putnam | J Nerv Ment Dis | 1986 | 3783140 | Yes |
| 4219 | 1109 | 1109.0 | 22.8 | 22.8 | Primary response genes induced by growth factors and tumor promoters. | H R Herschman | Annu Rev Biochem | 1991 | 1883198 | No |
| 4220 | 1109 | 1109.0 | 34.0 | 34.0 | Antibiotics and antibiotic resistance genes in natural environments. | Jose L Martinez | Science | 2008 | 18635792 | Yes |
| 4221 | 1108 | 1108.0 | 85.7 | 85.7 | Fundamental patterns of knowing in nursing. | B Carper | ANS Adv Nurs Sci | 1978 | 110216 | Yes |
| 4222 | 2216 | 1108.0 | 50.3 | 25.1 | Cell cycle control and cancer. | L H Hartwell, M B Kastan | Science | 1994 | 7997877 | No |
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