Unicorn Papers
, literally meaning "for (every) myriad (ten thousand)"
| No. | Citations | ECcit | RCR | ECRCR | Title | Authors | Journal | Year | PMID | Article(?) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 226677 | 226677.0 | 6239.2 | 6239.2 | Cleavage of structural proteins during the assembly of the head of bacteriophage T4. | U K Laemmli | Nature | 1970 | 5432063 | Yes |
| 2 | 184501 | 184501.0 | 6053.2 | 6053.2 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. | M M Bradford | Anal Biochem | 1976 | 942051 | Yes |
| 3 | 288769 | 72192.2 | 0.0 | 0.0 | Protein measurement with the Folin phenol reagent. | O H Lowry, N J Rosebrough, A L Farr, R J Randall | J Biol Chem | 1951 | 14907713 | Yes |
| 4 | 144085 | 72042.5 | 3973.2 | 1986.6 | Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. | K J Livak, T D Schmittgen | Methods | 2001 | 11846609 | Yes |
| 5 | 47109 | 47109.0 | 1513.5 | 1513.5 | A short history of SHELX. | George M Sheldrick | Acta Crystallogr A | 2008 | 18156677 | Yes |
| 6 | 39505 | 39505.0 | 1315.7 | 1315.7 | Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. | T Mosmann | J Immunol Methods | 1983 | 6606682 | Yes |
| 7 | 64841 | 32420.5 | 2017.2 | 1008.6 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. | P Chomczynski, N Sacchi | Anal Biochem | 1987 | 2440339 | Yes |
| 8 | 30923 | 30923.0 | 786.4 | 786.4 | MUSCLE: multiple sequence alignment with high accuracy and high throughput. | Robert C Edgar | Nucleic Acids Res | 2004 | 15034147 | Yes |
| 9 | 30281 | 30281.0 | 791.1 | 791.1 | Detection of specific sequences among DNA fragments separated by gel electrophoresis. | E M Southern | J Mol Biol | 1975 | 1195397 | Yes |
| 10 | 30091 | 30091.0 | 919.2 | 919.2 | The assessment and analysis of handedness: the Edinburgh inventory. | R C Oldfield | Neuropsychologia | 1971 | 5146491 | Yes |
| 11 | 29489 | 29489.0 | 685.6 | 685.6 | MicroRNAs: genomics, biogenesis, mechanism, and function. | David P Bartel | Cell | 2004 | 14744438 | No |
| 12 | 28383 | 28383.0 | 0.0 | 0.0 | A rating scale for depression. | M Hamilton | J Neurol Neurosurg Psychiatry | 1960 | 14399272 | Yes |
| 13 | 27059 | 27059.0 | 679.3 | 679.3 | A new mathematical model for relative quantification in real-time RT-PCR. | M W Pfaffl | Nucleic Acids Res | 2001 | 11328886 | Yes |
| 14 | 26254 | 26254.0 | 848.4 | 848.4 | Confidence Limits On Phylogenies: An Approach Using The Bootstrap. | Joseph Felsenstein | Evolution | 1985 | 28561359 | Yes |
| 15 | 25067 | 25067.0 | 707.4 | 707.4 | Projector augmented-wave method. | P E Blochl | Phys Rev B Condens Matter | 1994 | 9976227 | Yes |
| 16 | 49882 | 24941.0 | 1538.4 | 769.2 | Hallmarks of cancer: the next generation. | Douglas Hanahan, Robert A Weinberg | Cell | 2011 | 21376230 | No |
| 17 | 71503 | 23834.3 | 2558.2 | 852.7 | "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. | M F Folstein, S E Folstein, P R McHugh | J Psychiatr Res | 1975 | 1202204 | Yes |
| 18 | 70216 | 23405.3 | 2526.3 | 842.1 | Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. | Michael I Love, Wolfgang Huber, Simon Anders | Genome Biol | 2014 | 25516281 | Yes |
| 19 | 22490 | 22490.0 | 782.0 | 782.0 | Density-functional exchange-energy approximation with correct asymptotic behavior. | A D Becke | Phys Rev A Gen Phys | 1988 | 9900728 | Yes |
| 20 | 66566 | 22188.7 | 1625.6 | 541.9 | DNA sequencing with chain-terminating inhibitors. | F Sanger, S Nicklen, A R Coulson | Proc Natl Acad Sci U S A | 1977 | 271968 | Yes |
| 21 | 42575 | 21287.5 | 1370.0 | 685.0 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | N Saitou, M Nei | Mol Biol Evol | 1987 | 3447015 | Yes |
| 22 | 41751 | 20875.5 | 1301.2 | 650.6 | Fast gapped-read alignment with Bowtie 2. | Ben Langmead, Steven L Salzberg | Nat Methods | 2012 | 22388286 | Yes |
| 23 | 20861 | 20861.0 | 0.0 | 0.0 | Tissue sulfhydryl groups. | G L Ellman | Arch Biochem Biophys | 1959 | 13650640 | Yes |
| 24 | 20801 | 20801.0 | 839.8 | 839.8 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. | Alexandros Stamatakis | Bioinformatics | 2014 | 24451623 | Yes |
| 25 | 20545 | 20545.0 | 0.0 | 0.0 | The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. | E S Reynolds | J Cell Biol | 1963 | 13986422 | Yes |
| 26 | 40949 | 20474.5 | 1635.2 | 817.6 | The measurement of observer agreement for categorical data. | J R Landis, G G Koch | Biometrics | 1977 | 843571 | Yes |
| 27 | 60598 | 20199.3 | 1867.9 | 622.6 | Generalized Gradient Approximation Made Simple. | J P Perdew, K Burke, M Ernzerhof | Phys Rev Lett | 1996 | 10062328 | Yes |
| 28 | 38324 | 19162.0 | 1852.8 | 926.4 | Statistical methods for assessing agreement between two methods of clinical measurement. | J M Bland, D G Altman | Lancet | 1986 | 2868172 | Yes |
| 29 | 37947 | 18973.5 | 986.7 | 493.4 | Fast and accurate short read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2009 | 19451168 | Yes |
| 30 | 18914 | 18914.0 | 646.1 | 646.1 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. | M Kimura | J Mol Evol | 1980 | 7463489 | Yes |
| 31 | 18840 | 18840.0 | 853.1 | 853.1 | A power primer. | J Cohen | Psychol Bull | 1992 | 19565683 | Yes |
| 32 | 18223 | 18223.0 | 860.8 | 860.8 | Crystal structure refinement with SHELXL. | George M Sheldrick | Acta Crystallogr C Struct Chem | 2015 | 25567568 | Yes |
| 33 | 53735 | 17911.7 | 1605.0 | 535.0 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. | H Towbin, T Staehelin, J Gordon | Proc Natl Acad Sci U S A | 1979 | 388439 | Yes |
| 34 | 17475 | 17475.0 | 477.8 | 477.8 | Atherosclerosis--an inflammatory disease. | R Ross | N Engl J Med | 1999 | 9887164 | No |
| 35 | 34744 | 17372.0 | 1417.9 | 709.0 | The hospital anxiety and depression scale. | A S Zigmond, R P Snaith | Acta Psychiatr Scand | 1983 | 6880820 | Yes |
| 36 | 34109 | 17054.5 | 961.4 | 480.7 | Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. | G Kresse, J Furthmuller | Phys Rev B Condens Matter | 1996 | 9984901 | Yes |
| 37 | 33798 | 16899.0 | 0.0 | 0.0 | A rapid method of total lipid extraction and purification. | E G Bligh, W J Dyer | Can J Biochem Physiol | 1959 | 13671378 | Yes |
| 38 | 16853 | 16853.0 | 669.6 | 669.6 | Catalase in vitro. | H Aebi | Methods Enzymol | 1984 | 6727660 | Yes |
| 39 | 16783 | 16783.0 | 0.0 | 0.0 | Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. | B J Davis | Ann N Y Acad Sci | 1964 | 14240539 | Yes |
| 40 | 33104 | 16552.0 | 1276.7 | 638.4 | Meta-analysis in clinical trials. | R DerSimonian, N Laird | Control Clin Trials | 1986 | 3802833 | Yes |
| 41 | 16463 | 16463.0 | 422.7 | 422.7 | MicroRNAs: target recognition and regulatory functions. | David P Bartel | Cell | 2009 | 19167326 | No |
| 42 | 16241 | 16241.0 | 433.3 | 433.3 | High resolution two-dimensional electrophoresis of proteins. | P H O'Farrell | J Biol Chem | 1975 | 236308 | Yes |
| 43 | 15946 | 15946.0 | 0.0 | 0.0 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. | K Burton | Biochem J | 1956 | 13293190 | Yes |
| 44 | 15693 | 15693.0 | 613.2 | 613.2 | Investigation of the freely available easy-to-use software 'EZR' for medical statistics. | Y Kanda | Bone Marrow Transplant | 2013 | 23208313 | Yes |
| 45 | 46928 | 15642.7 | 1412.6 | 470.9 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. | J D Thompson, D G Higgins, T J Gibson | Nucleic Acids Res | 1994 | 7984417 | Yes |
| 46 | 46796 | 15598.7 | 1743.9 | 581.3 | Trimmomatic: a flexible trimmer for Illumina sequence data. | Anthony M Bolger, Marc Lohse, Bjoern Usadel | Bioinformatics | 2014 | 24695404 | Yes |
| 47 | 29733 | 14866.5 | 1111.6 | 555.8 | MAFFT multiple sequence alignment software version 7: improvements in performance and usability. | Kazutaka Katoh, Daron M Standley | Mol Biol Evol | 2013 | 23329690 | Yes |
| 48 | 14762 | 14762.0 | 530.5 | 530.5 | Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. | Andreas Stang | Eur J Epidemiol | 2010 | 20652370 | Yes |
| 49 | 14541 | 14541.0 | 372.9 | 372.9 | Xds. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124692 | Yes |
| 50 | 43528 | 14509.3 | 0.0 | 0.0 | A simple method for the isolation and purification of total lipides from animal tissues. | J Folch, M Lees, G H Sloane Stanley | J Biol Chem | 1957 | 13428781 | Yes |
| 51 | 28738 | 14369.0 | 896.7 | 448.4 | Quantifying heterogeneity in a meta-analysis. | Julian P T Higgins, Simon G Thompson | Stat Med | 2002 | 12111919 | Yes |
| 52 | 14207 | 14207.0 | 609.3 | 609.3 | Prokka: rapid prokaryotic genome annotation. | Torsten Seemann | Bioinformatics | 2014 | 24642063 | Yes |
| 53 | 28307 | 14153.5 | 601.9 | 300.9 | Coot: model-building tools for molecular graphics. | Paul Emsley, Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2004 | 15572765 | Yes |
| 54 | 28018 | 14009.0 | 654.2 | 327.1 | KEGG: kyoto encyclopedia of genes and genomes. | M Kanehisa, S Goto | Nucleic Acids Res | 2000 | 10592173 | Yes |
| 55 | 14008 | 14008.0 | 620.7 | 620.7 | Self-efficacy: toward a unifying theory of behavioral change. | A Bandura | Psychol Rev | 1977 | 847061 | Yes |
| 56 | 69978 | 13995.6 | 2080.5 | 416.1 | Basic local alignment search tool. | S F Altschul, W Gish, W Miller, E W Myers, D J Lipman | J Mol Biol | 1990 | 2231712 | Yes |
| 57 | 13797 | 13797.0 | 448.5 | 448.5 | Search and clustering orders of magnitude faster than BLAST. | Robert C Edgar | Bioinformatics | 2010 | 20709691 | Yes |
| 58 | 40657 | 13552.3 | 1447.2 | 482.4 | Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. | C Lee, W Yang, R G Parr | Phys Rev B Condens Matter | 1988 | 9944570 | Yes |
| 59 | 13534 | 13534.0 | 449.6 | 449.6 | The Psychophysics Toolbox. | D H Brainard | Spat Vis | 1997 | 9176952 | Yes |
| 60 | 40579 | 13526.3 | 1105.5 | 368.5 | VMD: visual molecular dynamics. | W Humphrey, A Dalke, K Schulten | J Mol Graph | 1996 | 8744570 | Yes |
| 61 | 26828 | 13414.0 | 1193.5 | 596.8 | The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. | J E Ware, C D Sherbourne | Med Care | 1992 | 1593914 | Yes |
| 62 | 13307 | 13307.0 | 225.0 | 225.0 | The genetics of Caenorhabditis elegans. | S Brenner | Genetics | 1974 | 4366476 | Yes |
| 63 | 39876 | 13292.0 | 1329.0 | 443.0 | NIH Image to ImageJ: 25 years of image analysis. | Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri | Nat Methods | 2012 | 22930834 | No |
| 64 | 12896 | 12896.0 | 436.0 | 436.0 | Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). | J F Kurtzke | Neurology | 1983 | 6685237 | Yes |
| 65 | 12665 | 12665.0 | 0.0 | 0.0 | Phosphorus assay in column chromatography. | G R Bartlett | J Biol Chem | 1959 | 13641241 | Yes |
| 66 | 12645 | 12645.0 | 506.7 | 506.7 | A new method for measuring daytime sleepiness: the Epworth sleepiness scale. | M W Johns | Sleep | 1991 | 1798888 | Yes |
| 67 | 12511 | 12511.0 | 579.9 | 579.9 | SHELXT - integrated space-group and crystal-structure determination. | George M Sheldrick | Acta Crystallogr A Found Adv | 2015 | 25537383 | Yes |
| 68 | 49300 | 12325.0 | 1599.9 | 400.0 | Measuring inconsistency in meta-analyses. | Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman | BMJ | 2003 | 12958120 | No |
| 69 | 24584 | 12292.0 | 558.6 | 279.3 | Processing of X-ray diffraction data collected in oscillation mode. | Z Otwinowski, W Minor | Methods Enzymol | 1997 | 27754618 | Yes |
| 70 | 11540 | 11540.0 | 318.7 | 318.7 | Semiempirical GGA-type density functional constructed with a long-range dispersion correction. | Stefan Grimme | J Comput Chem | 2006 | 16955487 | Yes |
| 71 | 22629 | 11314.5 | 974.9 | 487.4 | The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. | R M Baron, D A Kenny | J Pers Soc Psychol | 1986 | 3806354 | Yes |
| 72 | 22288 | 11144.0 | 701.2 | 350.6 | AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. | Oleg Trott, Arthur J Olson | J Comput Chem | 2010 | 19499576 | Yes |
| 73 | 33355 | 11118.3 | 1118.8 | 372.9 | The PHQ-9: validity of a brief depression severity measure. | K Kroenke, R L Spitzer, J B Williams | J Gen Intern Med | 2001 | 11556941 | Yes |
| 74 | 11075 | 11075.0 | 0.0 | 0.0 | On the origin of cancer cells. | O Warburg | Science | 1956 | 13298683 | Yes |
| 75 | 10956 | 10956.0 | 385.7 | 385.7 | Structure validation in chemical crystallography. | Anthony L Spek | Acta Crystallogr D Biol Crystallogr | 2009 | 19171970 | Yes |
| 76 | 10937 | 10937.0 | 308.2 | 308.2 | The blockade of immune checkpoints in cancer immunotherapy. | Drew M Pardoll | Nat Rev Cancer | 2012 | 22437870 | No |
| 77 | 21558 | 10779.0 | 570.7 | 285.4 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. | A P Feinberg, B Vogelstein | Anal Biochem | 1983 | 6312838 | Yes |
| 78 | 43010 | 10752.5 | 1546.9 | 386.7 | Bias in meta-analysis detected by a simple, graphical test. | M Egger, G Davey Smith, M Schneider, C Minder | BMJ | 1997 | 9310563 | Yes |
| 79 | 10739 | 10739.0 | 462.4 | 462.4 | Psychophysical bases of perceived exertion. | G A Borg | Med Sci Sports Exerc | 1982 | 7154893 | Yes |
| 80 | 42808 | 10702.0 | 1599.9 | 400.0 | A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. | M E Charlson, P Pompei, K L Ales, C R MacKenzie | J Chronic Dis | 1987 | 3558716 | Yes |
| 81 | 31955 | 10651.7 | 860.7 | 286.9 | edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. | Mark D Robinson, Davis J McCarthy, Gordon K Smyth | Bioinformatics | 2010 | 19910308 | Yes |
| 82 | 10589 | 10589.0 | 445.4 | 445.4 | Minimap2: pairwise alignment for nucleotide sequences. | Heng Li | Bioinformatics | 2018 | 29750242 | Yes |
| 83 | 10537 | 10537.0 | 300.9 | 300.9 | Evolutionary trees from DNA sequences: a maximum likelihood approach. | J Felsenstein | J Mol Evol | 1981 | 7288891 | Yes |
| 84 | 10419 | 10419.0 | 261.3 | 261.3 | PAML 4: phylogenetic analysis by maximum likelihood. | Ziheng Yang | Mol Biol Evol | 2007 | 17483113 | Yes |
| 85 | 10317 | 10317.0 | 0.0 | 0.0 | Improvements in epoxy resin embedding methods. | J H Luft | J Biophys Biochem Cytol | 1961 | 13764136 | Yes |
| 86 | 20595 | 10297.5 | 566.5 | 283.2 | Analyzing real-time PCR data by the comparative C(T) method. | Thomas D Schmittgen, Kenneth J Livak | Nat Protoc | 2008 | 18546601 | Yes |
| 87 | 10290 | 10290.0 | 221.9 | 221.9 | Mfold web server for nucleic acid folding and hybridization prediction. | Michael Zuker | Nucleic Acids Res | 2003 | 12824337 | Yes |
| 88 | 20548 | 10274.0 | 496.3 | 248.2 | BEDTools: a flexible suite of utilities for comparing genomic features. | Aaron R Quinlan, Ira M Hall | Bioinformatics | 2010 | 20110278 | Yes |
| 89 | 10269 | 10269.0 | 271.3 | 271.3 | Canonical dynamics: Equilibrium phase-space distributions. | W G Hoover | Phys Rev A Gen Phys | 1985 | 9895674 | Yes |
| 90 | 10239 | 10239.0 | 416.6 | 416.6 | UPARSE: highly accurate OTU sequences from microbial amplicon reads. | Robert C Edgar | Nat Methods | 2013 | 23955772 | Yes |
| 91 | 10051 | 10051.0 | 305.0 | 305.0 | Vitamin D deficiency. | Michael F Holick | N Engl J Med | 2007 | 17634462 | No |
| 92 | 19827 | 9913.5 | 0.0 | 0.0 | The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. | K Weber, M Osborn | J Biol Chem | 1969 | 5806584 | Yes |
| 93 | 19738 | 9869.0 | 508.1 | 254.1 | A simple method for displaying the hydropathic character of a protein. | J Kyte, R F Doolittle | J Mol Biol | 1982 | 7108955 | Yes |
| 94 | 19727 | 9863.5 | 1231.0 | 615.5 | A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. | Terry K Koo, Mae Y Li | J Chiropr Med | 2016 | 27330520 | Yes |
| 95 | 9836 | 9836.0 | 269.5 | 269.5 | Apoptosis: a review of programmed cell death. | Susan Elmore | Toxicol Pathol | 2007 | 17562483 | No |
| 96 | 39203 | 9800.8 | 1409.0 | 352.2 | G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. | Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner | Behav Res Methods | 2007 | 17695343 | Yes |
| 97 | 19576 | 9788.0 | 483.2 | 241.6 | WGCNA: an R package for weighted correlation network analysis. | Peter Langfelder, Steve Horvath | BMC Bioinformatics | 2008 | 19114008 | Yes |
| 98 | 9771 | 9771.0 | 0.0 | 0.0 | Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. | D I Arnon | Plant Physiol | 1949 | 16654194 | Yes |
| 99 | 19511 | 9755.5 | 435.4 | 217.7 | The hallmarks of cancer. | D Hanahan, R A Weinberg | Cell | 2000 | 10647931 | No |
| 100 | 29249 | 9749.7 | 766.2 | 255.4 | Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nat Protoc | 2009 | 19131956 | Yes |
| 101 | 9748 | 9748.0 | 270.9 | 270.9 | RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. | Alexandros Stamatakis | Bioinformatics | 2006 | 16928733 | Yes |
| 102 | 9705 | 9705.0 | 327.9 | 327.9 | Banting lecture 1988. Role of insulin resistance in human disease. | G M Reaven | Diabetes | 1988 | 3056758 | No |
| 103 | 28963 | 9654.3 | 1114.8 | 371.6 | Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. | Allison Tong, Peter Sainsbury, Jonathan Craig | Int J Qual Health Care | 2007 | 17872937 | Yes |
| 104 | 19267 | 9633.5 | 732.0 | 366.0 | Three approaches to qualitative content analysis. | Hsiu-Fang Hsieh, Sarah E Shannon | Qual Health Res | 2005 | 16204405 | Yes |
| 105 | 9576 | 9576.0 | 259.5 | 259.5 | Studies on transformation of Escherichia coli with plasmids. | D Hanahan | J Mol Biol | 1983 | 6345791 | Yes |
| 106 | 18979 | 9489.5 | 434.6 | 217.3 | Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. | Kazutoshi Takahashi, Shinya Yamanaka | Cell | 2006 | 16904174 | Yes |
| 107 | 47428 | 9485.6 | 1911.8 | 382.4 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | PLoS Med | 2009 | 19621072 | No |
| 108 | 9479 | 9479.0 | 263.5 | 263.5 | Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. | M C Hochberg | Arthritis Rheum | 1997 | 9324032 | Yes |
| 109 | 28289 | 9429.7 | 1449.3 | 483.1 | MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. | Sudhir Kumar, Glen Stecher, Koichiro Tamura | Mol Biol Evol | 2016 | 27004904 | Yes |
| 110 | 9297 | 9297.0 | 290.9 | 290.9 | AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. | R W Cox | Comput Biomed Res | 1996 | 8812068 | Yes |
| 111 | 9292 | 9292.0 | 0.0 | 0.0 | The assessment of anxiety states by rating. | M Hamilton | Br J Med Psychol | 1959 | 13638508 | Yes |
| 112 | 9252 | 9252.0 | 241.8 | 241.8 | Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. | P S Thomas | Proc Natl Acad Sci U S A | 1980 | 6159641 | Yes |
| 113 | 9233 | 9233.0 | 272.8 | 272.8 | The pathogenesis of atherosclerosis: a perspective for the 1990s. | R Ross | Nature | 1993 | 8479518 | No |
| 114 | 27373 | 9124.3 | 954.6 | 318.2 | Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. | Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien | Ann Surg | 2004 | 15273542 | Yes |
| 115 | 9120 | 9120.0 | 189.9 | 189.9 | Linear models and empirical bayes methods for assessing differential expression in microarray experiments. | Gordon K Smyth | Stat Appl Genet Mol Biol | 2004 | 16646809 | Yes |
| 116 | 9077 | 9077.0 | 242.9 | 242.9 | Integrins: versatility, modulation, and signaling in cell adhesion. | R O Hynes | Cell | 1992 | 1555235 | No |
| 117 | 8972 | 8972.0 | 198.7 | 198.7 | The functions of animal microRNAs. | Victor Ambros | Nature | 2004 | 15372042 | No |
| 118 | 8929 | 8929.0 | 442.6 | 442.6 | Comparative fit indexes in structural models. | P M Bentler | Psychol Bull | 1990 | 2320703 | Yes |
| 119 | 8804 | 8804.0 | 391.1 | 391.1 | Interrater reliability: the kappa statistic. | Mary L McHugh | Biochem Med (Zagreb) | 2012 | 23092060 | Yes |
| 120 | 17407 | 8703.5 | 413.7 | 206.8 | Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. | S J Clough, A F Bent | Plant J | 1998 | 10069079 | Yes |
| 121 | 8526 | 8526.0 | 288.5 | 288.5 | An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. | Peter C Austin | Multivariate Behav Res | 2011 | 21818162 | Yes |
| 122 | 8493 | 8493.0 | 238.9 | 238.9 | Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. | F Tajima | Genetics | 1989 | 2513255 | Yes |
| 123 | 16962 | 8481.0 | 533.9 | 266.9 | EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. | Arnaud Delorme, Scott Makeig | J Neurosci Methods | 2004 | 15102499 | Yes |
| 124 | 8413 | 8413.0 | 331.2 | 331.2 | The Strengths and Difficulties Questionnaire: a research note. | R Goodman | J Child Psychol Psychiatry | 1997 | 9255702 | Yes |
| 125 | 8407 | 8407.0 | 278.2 | 278.2 | The Clinical Dementia Rating (CDR): current version and scoring rules. | J C Morris | Neurology | 1993 | 8232972 | Yes |
| 126 | 16811 | 8405.5 | 591.2 | 295.6 | Multiwfn: a multifunctional wavefunction analyzer. | Tian Lu, Feiwu Chen | J Comput Chem | 2012 | 22162017 | Yes |
| 127 | 8381 | 8381.0 | 230.0 | 230.0 | Fast robust automated brain extraction. | Stephen M Smith | Hum Brain Mapp | 2002 | 12391568 | No |
| 128 | 16593 | 8296.5 | 458.1 | 229.1 | RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. | Bo Li, Colin N Dewey | BMC Bioinformatics | 2011 | 21816040 | Yes |
| 129 | 16525 | 8262.5 | 442.6 | 221.3 | MrBayes 3: Bayesian phylogenetic inference under mixed models. | Fredrik Ronquist, John P Huelsenbeck | Bioinformatics | 2003 | 12912839 | Yes |
| 130 | 8192 | 8192.0 | 235.4 | 235.4 | A modified poisson regression approach to prospective studies with binary data. | Guangyong Zou | Am J Epidemiol | 2004 | 15033648 | Yes |
| 131 | 16344 | 8172.0 | 459.9 | 229.9 | Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. | Florian Weigend, Reinhart Ahlrichs | Phys Chem Chem Phys | 2005 | 16240044 | Yes |
| 132 | 8164 | 8164.0 | 0.0 | 0.0 | Solvent content of protein crystals. | B W Matthews | J Mol Biol | 1968 | 5700707 | Yes |
| 133 | 8153 | 8153.0 | 177.6 | 177.6 | Chromatin modifications and their function. | Tony Kouzarides | Cell | 2007 | 17320507 | No |
| 134 | 8095 | 8095.0 | 151.9 | 151.9 | Tumor angiogenesis: therapeutic implications. | J Folkman | N Engl J Med | 1971 | 4938153 | No |
| 135 | 8059 | 8059.0 | 272.4 | 272.4 | Density-functional approximation for the correlation energy of the inhomogeneous electron gas. | J P Perdew | Phys Rev B Condens Matter | 1986 | 9938299 | Yes |
| 136 | 7960 | 7960.0 | 221.1 | 221.1 | "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. | W N Burnette | Anal Biochem | 1981 | 6266278 | Yes |
| 137 | 7919 | 7919.0 | 226.2 | 226.2 | A simplification of the protein assay method of Lowry et al. which is more generally applicable. | G L Peterson | Anal Biochem | 1977 | 603028 | Yes |
| 138 | 7890 | 7890.0 | 261.6 | 261.6 | The VideoToolbox software for visual psychophysics: transforming numbers into movies. | D G Pelli | Spat Vis | 1997 | 9176953 | Yes |
| 139 | 23569 | 7856.3 | 690.5 | 230.2 | Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. | W T Friedewald, R I Levy, D S Fredrickson | Clin Chem | 1972 | 4337382 | Yes |
| 140 | 7799 | 7799.0 | 224.3 | 224.3 | The role of protein kinase C in cell surface signal transduction and tumour promotion. | Y Nishizuka | Nature | 1984 | 6232463 | No |
| 141 | 7746 | 7746.0 | 0.0 | 0.0 | Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. | A Boyum | Scand J Clin Lab Invest Suppl | 1968 | 4179068 | Yes |
| 142 | 7732 | 7732.0 | 212.0 | 212.0 | Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. | J R Vane | Nat New Biol | 1971 | 5284360 | Yes |
| 143 | 53850 | 7692.9 | 1484.0 | 212.0 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. | S F Altschul, T L Madden, A A Schaffer, J Zhang, Z Zhang, W Miller, D J Lipman | Nucleic Acids Res | 1997 | 9254694 | No |
| 144 | 7431 | 7431.0 | 0.0 | 0.0 | A low-viscosity epoxy resin embedding medium for electron microscopy. | A R Spurr | J Ultrastruct Res | 1969 | 4887011 | Yes |
| 145 | 7406 | 7406.0 | 0.0 | 0.0 | Index for rating diagnostic tests. | W J Youden | Cancer | 1950 | 15405679 | Yes |
| 146 | 7401 | 7401.0 | 266.9 | 266.9 | FreeSurfer. | Bruce Fischl | Neuroimage | 2012 | 22248573 | No |
| 147 | 7397 | 7397.0 | 260.4 | 260.4 | Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. | Ilan H Meyer | Psychol Bull | 2003 | 12956539 | No |
| 148 | 7358 | 7358.0 | 644.8 | 644.8 | Hallmarks of Cancer: New Dimensions. | Douglas Hanahan | Cancer Discov | 2022 | 35022204 | No |
| 149 | 14547 | 7273.5 | 621.0 | 310.5 | Intraclass correlations: uses in assessing rater reliability. | P E Shrout, J L Fleiss | Psychol Bull | 1979 | 18839484 | No |
| 150 | 7208 | 7208.0 | 0.0 | 0.0 | A Self-Rating Depression Scale. | W W Zung | Arch Gen Psychiatry | 1965 | 14221692 | Yes |
| 151 | 7106 | 7106.0 | 204.9 | 204.9 | TreeView: an application to display phylogenetic trees on personal computers. | R D Page | Comput Appl Biosci | 1996 | 8902363 | Yes |
| 152 | 7106 | 7106.0 | 321.1 | 321.1 | Executive functions. | Adele Diamond | Annu Rev Psychol | 2013 | 23020641 | No |
| 153 | 42456 | 7076.0 | 1545.8 | 257.6 | Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. | Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde | J Biomed Inform | 2009 | 18929686 | Yes |
| 154 | 14085 | 7042.5 | 339.4 | 169.7 | Continuous cultures of fused cells secreting antibody of predefined specificity. | G Kohler, C Milstein | Nature | 1975 | 1172191 | Yes |
| 155 | 6997 | 6997.0 | 177.7 | 177.7 | Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. | J Castresana | Mol Biol Evol | 2000 | 10742046 | Yes |
| 156 | 6962 | 6962.0 | 144.9 | 144.9 | Integrins: bidirectional, allosteric signaling machines. | Richard O Hynes | Cell | 2002 | 12297042 | No |
| 157 | 6927 | 6927.0 | 176.2 | 176.2 | Inflammation and metabolic disorders. | Gokhan S Hotamisligil | Nature | 2006 | 17167474 | No |
| 158 | 27682 | 6920.5 | 825.6 | 206.4 | clusterProfiler: an R package for comparing biological themes among gene clusters. | Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He | OMICS | 2012 | 22455463 | Yes |
| 159 | 13775 | 6887.5 | 465.8 | 232.9 | The meaning and use of the area under a receiver operating characteristic (ROC) curve. | J A Hanley, B J McNeil | Radiology | 1982 | 7063747 | Yes |
| 160 | 6878 | 6878.0 | 187.8 | 187.8 | The steroid and thyroid hormone receptor superfamily. | R M Evans | Science | 1988 | 3283939 | No |
| 161 | 6850 | 6850.0 | 169.9 | 169.9 | Inflammation, atherosclerosis, and coronary artery disease. | Goran K Hansson | N Engl J Med | 2005 | 15843671 | No |
| 162 | 6785 | 6785.0 | 226.9 | 226.9 | Ethical guidelines for investigations of experimental pain in conscious animals. | Manfred Zimmermann | Pain | 1983 | 6877845 | No |
| 163 | 13538 | 6769.0 | 0.0 | 0.0 | Statistical aspects of the analysis of data from retrospective studies of disease. | N Mantel, W Haenszel | J Natl Cancer Inst | 1959 | 13655060 | Yes |
| 164 | 20260 | 6753.3 | 790.5 | 263.5 | Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. | H Ohkawa, N Ohishi, K Yagi | Anal Biochem | 1979 | 36810 | Yes |
| 165 | 13466 | 6733.0 | 342.1 | 171.1 | Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. | Y Cheng, W H Prusoff | Biochem Pharmacol | 1973 | 4202581 | Yes |
| 166 | 6717 | 6717.0 | 0.0 | 0.0 | The thiobarbituric acid assay of sialic acids. | L Warren | J Biol Chem | 1959 | 13672998 | Yes |
| 167 | 20100 | 6700.0 | 640.4 | 213.5 | featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. | Yang Liao, Gordon K Smyth, Wei Shi | Bioinformatics | 2014 | 24227677 | Yes |
| 168 | 13399 | 6699.5 | 535.3 | 267.6 | phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. | Paul J McMurdie, Susan Holmes | PLoS One | 2013 | 23630581 | Yes |
| 169 | 6670 | 6670.0 | 162.0 | 162.0 | Tandem repeats finder: a program to analyze DNA sequences. | G Benson | Nucleic Acids Res | 1999 | 9862982 | Yes |
| 170 | 6638 | 6638.0 | 169.9 | 169.9 | Biochemistry and molecular cell biology of diabetic complications. | M Brownlee | Nature | 2001 | 11742414 | Yes |
| 171 | 6617 | 6617.0 | 179.1 | 179.1 | Angiogenesis in cancer, vascular, rheumatoid and other disease. | J Folkman | Nat Med | 1995 | 7584949 | No |
| 172 | 19834 | 6611.3 | 573.2 | 191.1 | A new generation of Ca2+ indicators with greatly improved fluorescence properties. | G Grynkiewicz, M Poenie, R Y Tsien | J Biol Chem | 1985 | 3838314 | Yes |
| 173 | 13151 | 6575.5 | 430.8 | 215.4 | Prediction of creatinine clearance from serum creatinine. | D W Cockcroft, M H Gault | Nephron | 1976 | 1244564 | Yes |
| 174 | 6557 | 6557.0 | 153.2 | 153.2 | Inflammation in atherosclerosis. | Peter Libby | Nature | 2002 | 12490960 | No |
| 175 | 6551 | 6551.0 | 174.8 | 174.8 | Adhesion receptors of the immune system. | T A Springer | Nature | 1990 | 1974032 | No |
| 176 | 6548 | 6548.0 | 168.1 | 168.1 | Free radicals in the physiological control of cell function. | Wulf Droge | Physiol Rev | 2002 | 11773609 | No |
| 177 | 6545 | 6545.0 | 193.2 | 193.2 | A fast diffeomorphic image registration algorithm. | John Ashburner | Neuroimage | 2007 | 17761438 | Yes |
| 178 | 6528 | 6528.0 | 126.3 | 126.3 | BLAT--the BLAST-like alignment tool. | W James Kent | Genome Res | 2002 | 11932250 | Yes |
| 179 | 13047 | 6523.5 | 366.9 | 183.4 | Neuropathological stageing of Alzheimer-related changes. | H Braak, E Braak | Acta Neuropathol | 1991 | 1759558 | No |
| 180 | 6516 | 6516.0 | 256.8 | 256.8 | Whatever happened to qualitative description? | M Sandelowski | Res Nurs Health | 2000 | 10940958 | No |
| 181 | 6494 | 6494.0 | 143.5 | 143.5 | p53, the cellular gatekeeper for growth and division. | A J Levine | Cell | 1997 | 9039259 | No |
| 182 | 6432 | 6432.0 | 133.0 | 133.0 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel | Proc Natl Acad Sci U S A | 1985 | 3881765 | Yes |
| 183 | 6403 | 6403.0 | 150.0 | 150.0 | MUSCLE: a multiple sequence alignment method with reduced time and space complexity. | Robert C Edgar | BMC Bioinformatics | 2004 | 15318951 | Yes |
| 184 | 25532 | 6383.0 | 808.8 | 202.2 | A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. | Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg | J Chem Phys | 2010 | 20423165 | Yes |
| 185 | 6364 | 6364.0 | 0.0 | 0.0 | The Environment And Disease: Association Or Causation? | A B Hill | Proc R Soc Med | 1965 | 14283879 | Yes |
| 186 | 12693 | 6346.5 | 297.3 | 148.7 | One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. | K A Datsenko, B L Wanner | Proc Natl Acad Sci U S A | 2000 | 10829079 | Yes |
| 187 | 6329 | 6329.0 | 159.7 | 159.7 | Antimicrobial peptides of multicellular organisms. | Michael Zasloff | Nature | 2002 | 11807545 | Yes |
| 188 | 12653 | 6326.5 | 294.2 | 147.1 | Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. | W Kabsch, C Sander | Biopolymers | 1983 | 6667333 | Yes |
| 189 | 12515 | 6257.5 | 338.6 | 169.3 | MRBAYES: Bayesian inference of phylogenetic trees. | J P Huelsenbeck, F Ronquist | Bioinformatics | 2001 | 11524383 | Yes |
| 190 | 6231 | 6231.0 | 143.2 | 143.2 | Modification of seizure activity by electrical stimulation. II. Motor seizure. | R J Racine | Electroencephalogr Clin Neurophysiol | 1972 | 4110397 | Yes |
| 191 | 6215 | 6215.0 | 172.5 | 172.5 | How mitochondria produce reactive oxygen species. | Michael P Murphy | Biochem J | 2009 | 19061483 | No |
| 192 | 24847 | 6211.8 | 637.1 | 159.3 | Features and development of Coot. | P Emsley, B Lohkamp, W G Scott, K Cowtan | Acta Crystallogr D Biol Crystallogr | 2010 | 20383002 | Yes |
| 193 | 6169 | 6169.0 | 229.2 | 229.2 | The need for a new medical model: a challenge for biomedicine. | G L Engel | Science | 1977 | 847460 | Yes |
| 194 | 12293 | 6146.5 | 351.9 | 175.9 | A rapid alkaline extraction procedure for screening recombinant plasmid DNA. | H C Birnboim, J Doly | Nucleic Acids Res | 1979 | 388356 | Yes |
| 195 | 12270 | 6135.0 | 275.3 | 137.7 | MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. | Jurgen Cox, Matthias Mann | Nat Biotechnol | 2008 | 19029910 | Yes |
| 196 | 6123 | 6123.0 | 176.7 | 176.7 | Mild cognitive impairment as a diagnostic entity. | R C Petersen | J Intern Med | 2004 | 15324362 | No |
| 197 | 12178 | 6089.0 | 432.4 | 216.2 | Operating characteristics of a rank correlation test for publication bias. | C B Begg, M Mazumdar | Biometrics | 1994 | 7786990 | Yes |
| 198 | 6086 | 6086.0 | 158.1 | 158.1 | G proteins: transducers of receptor-generated signals. | A G Gilman | Annu Rev Biochem | 1987 | 3113327 | No |
| 199 | 6060 | 6060.0 | 158.1 | 158.1 | Inositol trisphosphate and calcium signalling. | M J Berridge | Nature | 1993 | 8381210 | No |
| 200 | 6035 | 6035.0 | 276.9 | 276.9 | Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. | Daniel Lakens | Front Psychol | 2013 | 24324449 | No |
| 201 | 12013 | 6006.5 | 309.5 | 154.8 | Differential expression analysis for sequence count data. | Simon Anders, Wolfgang Huber | Genome Biol | 2010 | 20979621 | Yes |
| 202 | 23961 | 5990.2 | 623.5 | 155.9 | Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. | J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter | Biochemistry | 1979 | 518835 | Yes |
| 203 | 5976 | 5976.0 | 219.8 | 219.8 | Orienting of attention. | M I Posner | Q J Exp Psychol | 1980 | 7367577 | Yes |
| 204 | 5972 | 5972.0 | 247.2 | 247.2 | Revisiting the behavioral model and access to medical care: does it matter? | R M Andersen | J Health Soc Behav | 1995 | 7738325 | Yes |
| 205 | 5963 | 5963.0 | 0.0 | 0.0 | Development of a rating scale for primary depressive illness. | M Hamilton | Br J Soc Clin Psychol | 1967 | 6080235 | Yes |
| 206 | 5961 | 5961.0 | 149.9 | 149.9 | Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. | T A Springer | Cell | 1994 | 7507411 | No |
| 207 | 11922 | 5961.0 | 328.3 | 164.2 | Ab initio molecular dynamics for liquid metals. | G Kresse, J Hafner | Phys Rev B Condens Matter | 1993 | 10004490 | Yes |
| 208 | 5948 | 5948.0 | 200.3 | 200.3 | jModelTest: phylogenetic model averaging. | David Posada | Mol Biol Evol | 2008 | 18397919 | Yes |
| 209 | 17820 | 5940.0 | 725.8 | 241.9 | Deep learning. | Yann LeCun, Yoshua Bengio, Geoffrey Hinton | Nature | 2015 | 26017442 | No |
| 210 | 11861 | 5930.5 | 267.9 | 133.9 | Inflammation and cancer. | Lisa M Coussens, Zena Werb | Nature | 2002 | 12490959 | No |
| 211 | 17791 | 5930.3 | 678.7 | 226.2 | The positive and negative syndrome scale (PANSS) for schizophrenia. | S R Kay, A Fiszbein, L A Opler | Schizophr Bull | 1987 | 3616518 | Yes |
| 212 | 5886 | 5886.0 | 0.0 | 0.0 | Aging: a theory based on free radical and radiation chemistry. | D Harman | J Gerontol | 1956 | 13332224 | Yes |
| 213 | 11754 | 5877.0 | 433.4 | 216.7 | A new depression scale designed to be sensitive to change. | S A Montgomery, M Asberg | Br J Psychiatry | 1979 | 444788 | Yes |
| 214 | 11563 | 5781.5 | 470.9 | 235.4 | Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. | U H Graneheim, B Lundman | Nurse Educ Today | 2004 | 14769454 | No |
| 215 | 5780 | 5780.0 | 0.0 | 0.0 | Evaluation of survival data and two new rank order statistics arising in its consideration. | N Mantel | Cancer Chemother Rep | 1966 | 5910392 | Yes |
| 216 | 5779 | 5779.0 | 93.8 | 93.8 | Mutation and cancer: statistical study of retinoblastoma. | A G Knudson | Proc Natl Acad Sci U S A | 1971 | 5279523 | Yes |
| 217 | 11520 | 5760.0 | 725.6 | 362.8 | Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. | Zunyou Wu, Jennifer M McGoogan | JAMA | 2020 | 32091533 | Yes |
| 218 | 17240 | 5746.7 | 700.4 | 233.5 | A global measure of perceived stress. | S Cohen, T Kamarck, R Mermelstein | J Health Soc Behav | 1983 | 6668417 | Yes |
| 219 | 5741 | 5741.0 | 149.7 | 149.7 | Apoptosis in the pathogenesis and treatment of disease. | C B Thompson | Science | 1995 | 7878464 | No |
| 220 | 11465 | 5732.5 | 0.0 | 0.0 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. | T Omura, R Sato | J Biol Chem | 1964 | 14209971 | Yes |
| 221 | 11451 | 5725.5 | 0.0 | 0.0 | A series of normal stages in the development of the chick embryo. | V Hamburger, H L Hamilton | J Morphol | 1951 | 24539719 | Yes |
| 222 | 17110 | 5703.3 | 625.7 | 208.6 | HISAT: a fast spliced aligner with low memory requirements. | Daehwan Kim, Ben Langmead, Steven L Salzberg | Nat Methods | 2015 | 25751142 | Yes |
| 223 | 11357 | 5678.5 | 285.0 | 142.5 | A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. | Stephane Guindon, Olivier Gascuel | Syst Biol | 2003 | 14530136 | Yes |
| 224 | 5677 | 5677.0 | 173.6 | 173.6 | Developments of a water-maze procedure for studying spatial learning in the rat. | R Morris | J Neurosci Methods | 1984 | 6471907 | Yes |
| 225 | 5650 | 5650.0 | 0.0 | 0.0 | Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. | F Tietze | Anal Biochem | 1969 | 4388022 | Yes |
| 226 | 16929 | 5643.0 | 467.8 | 155.9 | Inference of population structure using multilocus genotype data. | J K Pritchard, M Stephens, P Donnelly | Genetics | 2000 | 10835412 | Yes |
| 227 | 11279 | 5639.5 | 0.0 | 0.0 | A quantitative description of membrane current and its application to conduction and excitation in nerve. | A L Hodgkin, A F Huxley | J Physiol | 1952 | 12991237 | Yes |
| 228 | 16852 | 5617.3 | 519.7 | 173.2 | A simple salting out procedure for extracting DNA from human nucleated cells. | S A Miller, D D Dykes, H F Polesky | Nucleic Acids Res | 1988 | 3344216 | Yes |
| 229 | 5610 | 5610.0 | 131.6 | 131.6 | The biochemistry of apoptosis. | M O Hengartner | Nature | 2000 | 11048727 | No |
| 230 | 22321 | 5580.2 | 784.1 | 196.0 | A brief measure for assessing generalized anxiety disorder: the GAD-7. | Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Lowe | Arch Intern Med | 2006 | 16717171 | Yes |
| 231 | 11039 | 5519.5 | 253.2 | 126.6 | Dendritic cells and the control of immunity. | J Banchereau, R M Steinman | Nature | 1998 | 9521319 | No |
| 232 | 5514 | 5514.0 | 0.0 | 0.0 | The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. | P Lauren | Acta Pathol Microbiol Scand | 1965 | 14320675 | Yes |
| 233 | 5490 | 5490.0 | 111.4 | 111.4 | Epithelial-mesenchymal transitions in tumour progression. | Jean Paul Thiery | Nat Rev Cancer | 2002 | 12189386 | No |
| 234 | 5483 | 5483.0 | 184.5 | 184.5 | Updating P300: an integrative theory of P3a and P3b. | John Polich | Clin Neurophysiol | 2007 | 17573239 | No |
| 235 | 5470 | 5470.0 | 112.9 | 112.9 | Targeting HIF-1 for cancer therapy. | Gregg L Semenza | Nat Rev Cancer | 2003 | 13130303 | No |
| 236 | 5468 | 5468.0 | 146.8 | 146.8 | Emotion circuits in the brain. | J E LeDoux | Annu Rev Neurosci | 2000 | 10845062 | No |
| 237 | 10931 | 5465.5 | 254.0 | 127.0 | The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. | John Hardy, Dennis J Selkoe | Science | 2002 | 12130773 | No |
| 238 | 10924 | 5462.0 | 263.1 | 131.6 | Sequencing end-labeled DNA with base-specific chemical cleavages. | A M Maxam, W Gilbert | Methods Enzymol | 1980 | 6246368 | Yes |
| 239 | 10860 | 5430.0 | 0.0 | 0.0 | Functional Evaluation: The Barthel Index. | F I Mahoney, D W Barthel | Md State Med J | 1965 | 14258950 | Yes |
| 240 | 16290 | 5430.0 | 559.1 | 186.4 | HTSeq--a Python framework to work with high-throughput sequencing data. | Simon Anders, Paul Theodor Pyl, Wolfgang Huber | Bioinformatics | 2015 | 25260700 | Yes |
| 241 | 10849 | 5424.5 | 335.7 | 167.8 | MODELTEST: testing the model of DNA substitution. | D Posada, K A Crandall | Bioinformatics | 1998 | 9918953 | Yes |
| 242 | 10832 | 5416.0 | 265.6 | 132.8 | Comparative protein modelling by satisfaction of spatial restraints. | A Sali, T L Blundell | J Mol Biol | 1993 | 8254673 | Yes |
| 243 | 5416 | 5416.0 | 157.7 | 157.7 | The Cambridge Structural Database: a quarter of a million crystal structures and rising. | Frank H Allen | Acta Crystallogr B | 2002 | 12037359 | Yes |
| 244 | 10828 | 5414.0 | 422.8 | 211.4 | Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods | 2008 | 18697684 | Yes |
| 245 | 26973 | 5394.6 | 791.8 | 158.4 | The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. | J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins | Nucleic Acids Res | 1997 | 9396791 | Yes |
| 246 | 10758 | 5379.0 | 0.0 | 0.0 | Assessment of older people: self-maintaining and instrumental activities of daily living. | M P Lawton, E M Brody | Gerontologist | 1969 | 5349366 | Yes |
| 247 | 5309 | 5309.0 | 138.4 | 138.4 | New M13 vectors for cloning. | J Messing | Methods Enzymol | 1983 | 6310323 | Yes |
| 248 | 5265 | 5265.0 | 131.9 | 131.9 | The NF-kappa B and I kappa B proteins: new discoveries and insights. | A S Baldwin | Annu Rev Immunol | 1996 | 8717528 | No |
| 249 | 5257 | 5257.0 | 157.7 | 157.7 | Studies and perspectives of protein kinase C. | Y Nishizuka | Science | 1986 | 3014651 | No |
| 250 | 5243 | 5243.0 | 196.4 | 196.4 | Oxygen-derived free radicals in postischemic tissue injury. | J M McCord | N Engl J Med | 1985 | 2981404 | No |
| 251 | 5221 | 5221.0 | 0.0 | 0.0 | [A micro-method of immuno-electrophoresis]. | J J Scheidegger | Int Arch Allergy Appl Immunol | 1955 | 13262900 | Yes |
| 252 | 10431 | 5215.5 | 291.5 | 145.8 | The rise of graphene. | A K Geim, K S Novoselov | Nat Mater | 2007 | 17330084 | Yes |
| 253 | 10427 | 5213.5 | 338.4 | 169.2 | The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. | R F Furchgott, J V Zawadzki | Nature | 1980 | 6253831 | Yes |
| 254 | 5211 | 5211.0 | 0.0 | 0.0 | Selective extraction of polyoma DNA from infected mouse cell cultures. | B Hirt | J Mol Biol | 1967 | 4291934 | Yes |
| 255 | 5210 | 5210.0 | 152.4 | 152.4 | Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. | Peter C Austin | Stat Med | 2009 | 19757444 | Yes |
| 256 | 15626 | 5208.7 | 502.4 | 167.5 | Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. | E R DeLong, D M DeLong, D L Clarke-Pearson | Biometrics | 1988 | 3203132 | Yes |
| 257 | 26031 | 5206.2 | 1097.1 | 219.4 | MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. | Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar | Mol Biol Evol | 2013 | 24132122 | Yes |
| 258 | 10372 | 5186.0 | 277.4 | 138.7 | Long short-term memory. | S Hochreiter, J Schmidhuber | Neural Comput | 1997 | 9377276 | Yes |
| 259 | 5182 | 5182.0 | 106.8 | 106.8 | Rho GTPases and the actin cytoskeleton. | A Hall | Science | 1998 | 9438836 | No |
| 260 | 15510 | 5170.0 | 703.6 | 234.5 | Development and validation of brief measures of positive and negative affect: the PANAS scales. | D Watson, L A Clark, A Tellegen | J Pers Soc Psychol | 1988 | 3397865 | Yes |
| 261 | 5168 | 5168.0 | 0.0 | 0.0 | Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. | W H Harris | J Bone Joint Surg Am | 1969 | 5783851 | Yes |
| 262 | 5160 | 5160.0 | 95.0 | 95.0 | The clonal evolution of tumor cell populations. | P C Nowell | Science | 1976 | 959840 | Yes |
| 263 | 10303 | 5151.5 | 284.2 | 142.1 | Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. | H Schagger, G Von Jagow | Anal Biochem | 1987 | 2449095 | Yes |
| 264 | 5150 | 5150.0 | 129.3 | 129.3 | Why most published research findings are false. | John P A Ioannidis | PLoS Med | 2005 | 16060722 | Yes |
| 265 | 5149 | 5149.0 | 201.5 | 201.5 | Analyzing Tables Of Statistical Tests. | William R Rice | Evolution | 1989 | 28568501 | Yes |
| 266 | 10292 | 5146.0 | 245.8 | 122.9 | A genetic model for colorectal tumorigenesis. | E R Fearon, B Vogelstein | Cell | 1990 | 2188735 | No |
| 267 | 25700 | 5140.0 | 0.0 | 0.0 | An inventory for measuring depression. | A T Beck, C H Ward, M Mendelson, J Mock, J Erbaugh | Arch Gen Psychiatry | 1961 | 13688369 | Yes |
| 268 | 10257 | 5128.5 | 421.2 | 210.6 | The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. | I F Benzie, J J Strain | Anal Biochem | 1996 | 8660627 | Yes |
| 269 | 5128 | 5128.0 | 98.8 | 98.8 | DNA methylation patterns and epigenetic memory. | Adrian Bird | Genes Dev | 2002 | 11782440 | No |
| 270 | 5110 | 5110.0 | 154.8 | 154.8 | DNA methylation age of human tissues and cell types. | Steve Horvath | Genome Biol | 2013 | 24138928 | Yes |
| 271 | 10204 | 5102.0 | 436.6 | 218.3 | The qualitative content analysis process. | Satu Elo, Helvi Kyngas | J Adv Nurs | 2008 | 18352969 | Yes |
| 272 | 35638 | 5091.1 | 833.7 | 119.1 | UCSF Chimera--a visualization system for exploratory research and analysis. | Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin | J Comput Chem | 2004 | 15264254 | Yes |
| 273 | 10161 | 5080.5 | 0.0 | 0.0 | Parkinsonism: onset, progression and mortality. | M M Hoehn, M D Yahr | Neurology | 1967 | 6067254 | Yes |
| 274 | 20254 | 5063.5 | 0.0 | 0.0 | A new and rapid colorimetric determination of acetylcholinesterase activity. | G L Ellman, K D Courtney, V Andres, R M Feather-Stone | Biochem Pharmacol | 1961 | 13726518 | Yes |
| 275 | 10104 | 5052.0 | 442.8 | 221.4 | The timed "Up & Go": a test of basic functional mobility for frail elderly persons. | D Podsiadlo, S Richardson | J Am Geriatr Soc | 1991 | 1991946 | Yes |
| 276 | 25186 | 5037.2 | 1010.2 | 202.0 | The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. | D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer | Psychiatry Res | 1989 | 2748771 | Yes |
| 277 | 15015 | 5005.0 | 554.2 | 184.7 | Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. | S M Hsu, L Raine, H Fanger | J Histochem Cytochem | 1981 | 6166661 | Yes |
| 278 | 4991 | 4991.0 | 142.8 | 142.8 | Accelerated Profile HMM Searches. | Sean R Eddy | PLoS Comput Biol | 2011 | 22039361 | Yes |
| 279 | 9966 | 4983.0 | 253.2 | 126.6 | Collective dynamics of 'small-world' networks. | D J Watts, S H Strogatz | Nature | 1998 | 9623998 | Yes |
| 280 | 19828 | 4957.0 | 918.9 | 229.7 | fastp: an ultra-fast all-in-one FASTQ preprocessor. | Shifu Chen, Yanqing Zhou, Yaru Chen, Jia Gu | Bioinformatics | 2018 | 30423086 | Yes |
| 281 | 4947 | 4947.0 | 162.6 | 162.6 | A protein binding assay for adenosine 3':5'-cyclic monophosphate. | A G Gilman | Proc Natl Acad Sci U S A | 1970 | 4318781 | Yes |
| 282 | 9875 | 4937.5 | 326.5 | 163.2 | FLASH: fast length adjustment of short reads to improve genome assemblies. | Tanja Magoc, Steven L Salzberg | Bioinformatics | 2011 | 21903629 | Yes |
| 283 | 9859 | 4929.5 | 314.7 | 157.3 | Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. | S Duval, R Tweedie | Biometrics | 2000 | 10877304 | Yes |
| 284 | 4912 | 4912.0 | 208.6 | 208.6 | The McGill Pain Questionnaire: major properties and scoring methods. | Ronald Melzack | Pain | 1975 | 1235985 | Yes |
| 285 | 4912 | 4912.0 | 0.0 | 0.0 | Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. | C B Laurell | Anal Biochem | 1966 | 5959431 | Yes |
| 286 | 4907 | 4907.0 | 101.4 | 101.4 | An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. | M Kozak | Nucleic Acids Res | 1987 | 3313277 | No |
| 287 | 9794 | 4897.0 | 0.0 | 0.0 | Radiological assessment of osteo-arthrosis. | J H Kellgren, J S Lawrence | Ann Rheum Dis | 1957 | 13498604 | Yes |
| 288 | 14670 | 4890.0 | 406.3 | 135.4 | Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. | C Yanisch-Perron, J Vieira, J Messing | Gene | 1985 | 2985470 | Yes |
| 289 | 9776 | 4888.0 | 324.8 | 162.4 | Ligand: a versatile computerized approach for characterization of ligand-binding systems. | P J Munson, D Rodbard | Anal Biochem | 1980 | 6254391 | Yes |
| 290 | 4886 | 4886.0 | 115.9 | 115.9 | Alzheimer's disease: genes, proteins, and therapy. | D J Selkoe | Physiol Rev | 2001 | 11274343 | No |
| 291 | 4872 | 4872.0 | 0.0 | 0.0 | The Limited In Vitro Lifetime Of Human Diploid Cell Strains. | L Hayflick | Exp Cell Res | 1965 | 14315085 | Yes |
| 292 | 4858 | 4858.0 | 179.7 | 179.7 | Emerging adulthood. A theory of development from the late teens through the twenties. | J J Arnett | Am Psychol | 2000 | 10842426 | Yes |
| 293 | 14553 | 4851.0 | 0.0 | 0.0 | Determination of serum proteins by means of the biuret reaction. | A G Gornall, C J Bardawill, M M David | J Biol Chem | 1949 | 18110453 | Yes |
| 294 | 4843 | 4843.0 | 112.3 | 112.3 | Prions. | S B Prusiner | Proc Natl Acad Sci U S A | 1998 | 9811807 | No |
| 295 | 4836 | 4836.0 | 110.8 | 110.8 | ras oncogenes in human cancer: a review. | J L Bos | Cancer Res | 1989 | 2547513 | No |
| 296 | 4833 | 4833.0 | 108.6 | 108.6 | Cancer cell cycles. | C J Sherr | Science | 1996 | 8939849 | No |
| 297 | 14479 | 4826.3 | 330.3 | 110.1 | Refinement of macromolecular structures by the maximum-likelihood method. | G N Murshudov, A A Vagin, E J Dodson | Acta Crystallogr D Biol Crystallogr | 1997 | 15299926 | Yes |
| 298 | 14441 | 4813.7 | 371.9 | 124.0 | A comprehensive set of sequence analysis programs for the VAX. | J Devereux, P Haeberli, O Smithies | Nucleic Acids Res | 1984 | 6546423 | Yes |
| 299 | 4811 | 4811.0 | 0.0 | 0.0 | Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. | M Rodbell | J Biol Chem | 1964 | 14169133 | Yes |
| 300 | 4791 | 4791.0 | 105.4 | 105.4 | Protein production by auto-induction in high density shaking cultures. | F William Studier | Protein Expr Purif | 2005 | 15915565 | Yes |
| 301 | 4789 | 4789.0 | 132.4 | 132.4 | Accurate Coulomb-fitting basis sets for H to Rn. | Florian Weigend | Phys Chem Chem Phys | 2006 | 16633586 | Yes |
| 302 | 4787 | 4787.0 | 184.6 | 184.6 | Measuring the accuracy of diagnostic systems. | J A Swets | Science | 1988 | 3287615 | No |
| 303 | 9568 | 4784.0 | 338.4 | 169.2 | Assessment of coma and impaired consciousness. A practical scale. | G Teasdale, B Jennett | Lancet | 1974 | 4136544 | Yes |
| 304 | 4780 | 4780.0 | 159.2 | 159.2 | Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). | Gunther Eysenbach | J Med Internet Res | 2004 | 15471760 | No |
| 305 | 9532 | 4766.0 | 174.4 | 87.2 | A new technique for the assay of infectivity of human adenovirus 5 DNA. | F L Graham, A J Van Der Eb | Virology | 1973 | 4705382 | Yes |
| 306 | 4748 | 4748.0 | 101.3 | 101.3 | Alternative activation of macrophages. | Siamon Gordon | Nat Rev Immunol | 2003 | 12511873 | No |
| 307 | 9492 | 4746.0 | 242.4 | 121.2 | Improved tools for biological sequence comparison. | W R Pearson, D J Lipman | Proc Natl Acad Sci U S A | 1988 | 3162770 | Yes |
| 308 | 4742 | 4742.0 | 125.1 | 125.1 | A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. | Heng Li | Bioinformatics | 2011 | 21903627 | Yes |
| 309 | 4730 | 4730.0 | 0.0 | 0.0 | Aggregation of blood platelets by adenosine diphosphate and its reversal. | G V Born | Nature | 1962 | 13871375 | Yes |
| 310 | 4728 | 4728.0 | 0.0 | 0.0 | The genetical evolution of social behaviour. I. | W D Hamilton | J Theor Biol | 1964 | 5875341 | Yes |
| 311 | 9441 | 4720.5 | 281.3 | 140.7 | Estimating F-Statistics For The Analysis Of Population Structure. | B S Weir, C Clark Cockerham | Evolution | 1984 | 28563791 | Yes |
| 312 | 9438 | 4719.0 | 0.0 | 0.0 | Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). | J M McCord, I Fridovich | J Biol Chem | 1969 | 5389100 | Yes |
| 313 | 14131 | 4710.3 | 576.6 | 192.2 | A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. | J Ware, M Kosinski, S D Keller | Med Care | 1996 | 8628042 | Yes |
| 314 | 4706 | 4706.0 | 162.9 | 162.9 | The pathogenesis of atherosclerosis--an update. | R Ross | N Engl J Med | 1986 | 3511384 | No |
| 315 | 4706 | 4706.0 | 187.9 | 187.9 | EuroQol: the current state of play. | R Brooks | Health Policy | 1996 | 10158943 | No |
| 316 | 4703 | 4703.0 | 120.0 | 120.0 | Origin and physiological roles of inflammation. | Ruslan Medzhitov | Nature | 2008 | 18650913 | No |
| 317 | 18737 | 4684.2 | 575.1 | 143.8 | MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. | Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2007 | 17488738 | Yes |
| 318 | 4682 | 4682.0 | 134.9 | 134.9 | Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. | P Matsudaira | J Biol Chem | 1987 | 3611052 | Yes |
| 319 | 4680 | 4680.0 | 99.6 | 99.6 | Wnt/beta-catenin signaling in development and disease. | Hans Clevers | Cell | 2006 | 17081971 | No |
| 320 | 4678 | 4678.0 | 117.3 | 117.3 | A rapid banding technique for human chromosomes. | M Seabright | Lancet | 1971 | 4107917 | Yes |
| 321 | 4670 | 4670.0 | 152.0 | 152.0 | How do you feel--now? The anterior insula and human awareness. | A D Bud Craig | Nat Rev Neurosci | 2009 | 19096369 | No |
| 322 | 4661 | 4661.0 | 124.4 | 124.4 | Drug combination studies and their synergy quantification using the Chou-Talalay method. | Ting-Chao Chou | Cancer Res | 2010 | 20068163 | Yes |
| 323 | 9306 | 4653.0 | 231.3 | 115.7 | Fast and accurate long-read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2010 | 20080505 | Yes |
| 324 | 9300 | 4650.0 | 226.3 | 113.2 | Primer3 on the WWW for general users and for biologist programmers. | S Rozen, H Skaletsky | Methods Mol Biol | 2000 | 10547847 | Yes |
| 325 | 4642 | 4642.0 | 108.9 | 108.9 | Cancer. p53, guardian of the genome. | D P Lane | Nature | 1992 | 1614522 | No |
| 326 | 4626 | 4626.0 | 176.2 | 176.2 | A concordance correlation coefficient to evaluate reproducibility. | L I Lin | Biometrics | 1989 | 2720055 | Yes |
| 327 | 4608 | 4608.0 | 0.0 | 0.0 | The detection of disease clustering and a generalized regression approach. | N Mantel | Cancer Res | 1967 | 6018555 | Yes |
| 328 | 9207 | 4603.5 | 255.8 | 127.9 | A synaptic model of memory: long-term potentiation in the hippocampus. | T V Bliss, G L Collingridge | Nature | 1993 | 8421494 | No |
| 329 | 9195 | 4597.5 | 225.8 | 112.9 | SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. | N Guex, M C Peitsch | Electrophoresis | 1997 | 9504803 | Yes |
| 330 | 4595 | 4595.0 | 0.0 | 0.0 | New methods for calculating metabolic rate with special reference to protein metabolism. | J B de B Weir | J Physiol | 1949 | 15394301 | Yes |
| 331 | 22971 | 4594.2 | 1343.6 | 268.7 | MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. | Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura | Mol Biol Evol | 2018 | 29722887 | Yes |
| 332 | 13747 | 4582.3 | 504.2 | 168.1 | Nitric oxide: physiology, pathophysiology, and pharmacology. | S Moncada, R M Palmer, E A Higgs | Pharmacol Rev | 1991 | 1852778 | No |
| 333 | 4580 | 4580.0 | 168.8 | 168.8 | KDIGO clinical practice guidelines for acute kidney injury. | Arif Khwaja | Nephron Clin Pract | 2012 | 22890468 | No |
| 334 | 45654 | 4565.4 | 1189.1 | 118.9 | The Sequence Alignment/Map format and SAMtools. | Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin, | Bioinformatics | 2009 | 19505943 | Yes |
| 335 | 4562 | 4562.0 | 100.8 | 100.8 | ras genes. | M Barbacid | Annu Rev Biochem | 1987 | 3304147 | No |
| 336 | 4562 | 4562.0 | 101.1 | 101.1 | Folding DNA to create nanoscale shapes and patterns. | Paul W K Rothemund | Nature | 2006 | 16541064 | Yes |
| 337 | 4559 | 4559.0 | 91.0 | 91.0 | The phosphoinositide 3-kinase pathway. | Lewis C Cantley | Science | 2002 | 12040186 | No |
| 338 | 4554 | 4554.0 | 95.2 | 95.2 | Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. | M Kozak | Cell | 1986 | 3943125 | Yes |
| 339 | 18192 | 4548.0 | 698.4 | 174.6 | Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. | Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang | Behav Res Methods | 2009 | 19897823 | Yes |
| 340 | 27284 | 4547.3 | 908.2 | 151.4 | Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. | D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner | Diabetologia | 1985 | 3899825 | Yes |
| 341 | 4547 | 4547.0 | 0.0 | 0.0 | Evolution in Mendelian Populations. | S Wright | Genetics | 1931 | 17246615 | Yes |
| 342 | 4483 | 4483.0 | 122.9 | 122.9 | Functions of DNA methylation: islands, start sites, gene bodies and beyond. | Peter A Jones | Nat Rev Genet | 2012 | 22641018 | No |
| 343 | 8958 | 4479.0 | 258.2 | 129.1 | Control of goal-directed and stimulus-driven attention in the brain. | Maurizio Corbetta, Gordon L Shulman | Nat Rev Neurosci | 2002 | 11994752 | No |
| 344 | 4475 | 4475.0 | 125.1 | 125.1 | Staphylococcus aureus infections. | F D Lowy | N Engl J Med | 1998 | 9709046 | No |
| 345 | 26717 | 4452.8 | 981.2 | 163.5 | MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. | Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2011 | 21546353 | Yes |
| 346 | 4449 | 4449.0 | 126.8 | 126.8 | Oxidative stress, antioxidants and stress tolerance. | Ron Mittler | Trends Plant Sci | 2002 | 12234732 | No |
| 347 | 4449 | 4449.0 | 109.0 | 109.0 | RELION: implementation of a Bayesian approach to cryo-EM structure determination. | Sjors H W Scheres | J Struct Biol | 2012 | 23000701 | Yes |
| 348 | 4447 | 4447.0 | 103.7 | 103.7 | Atherosclerosis. | A J Lusis | Nature | 2000 | 11001066 | No |
| 349 | 4446 | 4446.0 | 0.0 | 0.0 | The Scree Test For The Number Of Factors. | R B Cattell | Multivariate Behav Res | 1966 | 26828106 | Yes |
| 350 | 8890 | 4445.0 | 244.8 | 122.4 | tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. | T M Lowe, S R Eddy | Nucleic Acids Res | 1997 | 9023104 | Yes |
| 351 | 8883 | 4441.5 | 0.0 | 0.0 | A simplified method of evaluating dose-effect experiments. | J T Litchfield, F Wilcoxon | J Pharmacol Exp Ther | 1949 | 18152921 | Yes |
| 352 | 4440 | 4440.0 | 109.7 | 109.7 | Mechanisms of angiogenesis. | W Risau | Nature | 1997 | 9109485 | No |
| 353 | 4435 | 4435.0 | 112.1 | 112.1 | A new method for predicting signal sequence cleavage sites. | G Von Heijne | Nucleic Acids Res | 1986 | 3714490 | Yes |
| 354 | 8831 | 4415.5 | 293.8 | 146.9 | DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. | P Librado, J Rozas | Bioinformatics | 2009 | 19346325 | Yes |
| 355 | 4392 | 4392.0 | 0.0 | 0.0 | Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. | J Cohen | Psychol Bull | 1968 | 19673146 | Yes |
| 356 | 8772 | 4386.0 | 236.1 | 118.0 | A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. | W M Bonner, R A Laskey | Eur J Biochem | 1974 | 4850204 | Yes |
| 357 | 4380 | 4380.0 | 78.2 | 78.2 | Automated electron microscope tomography using robust prediction of specimen movements. | David N Mastronarde | J Struct Biol | 2005 | 16182563 | Yes |
| 358 | 8753 | 4376.5 | 197.0 | 98.5 | Inference of macromolecular assemblies from crystalline state. | Evgeny Krissinel, Kim Henrick | J Mol Biol | 2007 | 17681537 | Yes |
| 359 | 8744 | 4372.0 | 0.0 | 0.0 | Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. | D E Paglia, W N Valentine | J Lab Clin Med | 1967 | 6066618 | Yes |
| 360 | 4366 | 4366.0 | 113.7 | 113.7 | The origins and the future of microfluidics. | George M Whitesides | Nature | 2006 | 16871203 | No |
| 361 | 4357 | 4357.0 | 170.7 | 170.7 | Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. | M M Mesulam | J Histochem Cytochem | 1978 | 24068 | Yes |
| 362 | 4353 | 4353.0 | 131.9 | 131.9 | Glutamate neurotoxicity and diseases of the nervous system. | D W Choi | Neuron | 1988 | 2908446 | No |
| 363 | 4349 | 4349.0 | 176.4 | 176.4 | A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. | E Pfeiffer | J Am Geriatr Soc | 1975 | 1159263 | Yes |
| 364 | 4349 | 4349.0 | 227.8 | 227.8 | High-performance medicine: the convergence of human and artificial intelligence. | Eric J Topol | Nat Med | 2019 | 30617339 | No |
| 365 | 4346 | 4346.0 | 101.1 | 101.1 | PAML: a program package for phylogenetic analysis by maximum likelihood. | Z Yang | Comput Appl Biosci | 1997 | 9367129 | Yes |
| 366 | 13016 | 4338.7 | 430.0 | 143.3 | Effect of the damping function in dispersion corrected density functional theory. | Stefan Grimme, Stephan Ehrlich, Lars Goerigk | J Comput Chem | 2011 | 21370243 | Yes |
| 367 | 4336 | 4336.0 | 116.5 | 116.5 | Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. | Y Nishizuka | Science | 1992 | 1411571 | No |
| 368 | 39003 | 4333.7 | 1224.5 | 136.1 | STAR: ultrafast universal RNA-seq aligner. | Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras | Bioinformatics | 2013 | 23104886 | Yes |
| 369 | 4331 | 4331.0 | 127.3 | 127.3 | Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. | D Vanderbilt | Phys Rev B Condens Matter | 1990 | 9993096 | Yes |
| 370 | 8660 | 4330.0 | 220.5 | 110.2 | The plant immune system. | Jonathan D G Jones, Jeffery L Dangl | Nature | 2006 | 17108957 | No |
| 371 | 4328 | 4328.0 | 94.5 | 94.5 | Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. | Rakesh K Jain | Science | 2005 | 15637262 | No |
| 372 | 4324 | 4324.0 | 137.2 | 137.2 | EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. | W Klimesch | Brain Res Brain Res Rev | 1999 | 10209231 | No |
| 373 | 4323 | 4323.0 | 165.1 | 165.1 | Observational study of behavior: sampling methods. | J Altmann | Behaviour | 1974 | 4597405 | No |
| 374 | 4319 | 4319.0 | 82.3 | 82.3 | Principles that govern the folding of protein chains. | C B Anfinsen | Science | 1973 | 4124164 | Yes |
| 375 | 30206 | 4315.1 | 1087.4 | 155.3 | limma powers differential expression analyses for RNA-sequencing and microarray studies. | Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth | Nucleic Acids Res | 2015 | 25605792 | Yes |
| 376 | 4299 | 4299.0 | 90.5 | 90.5 | The retinoblastoma protein and cell cycle control. | R A Weinberg | Cell | 1995 | 7736585 | No |
| 377 | 8584 | 4292.0 | 0.0 | 0.0 | Preparation of iodine-131 labelled human growth hormone of high specific activity. | W M Hunter, F C Greenwood | Nature | 1962 | 14450081 | Yes |
| 378 | 4291 | 4291.0 | 0.0 | 0.0 | Estimation of nuclear population from microtome sections. | M Abercrombie | Anat Rec | 1946 | 21015608 | Yes |
| 379 | 4289 | 4289.0 | 87.4 | 87.4 | Hypoxia--a key regulatory factor in tumour growth. | Adrian L Harris | Nat Rev Cancer | 2002 | 11902584 | No |
| 380 | 4288 | 4288.0 | 79.5 | 79.5 | Generalized lacZ expression with the ROSA26 Cre reporter strain. | P Soriano | Nat Genet | 1999 | 9916792 | Yes |
| 381 | 4287 | 4287.0 | 92.1 | 92.1 | The green fluorescent protein. | R Y Tsien | Annu Rev Biochem | 1998 | 9759496 | No |
| 382 | 4271 | 4271.0 | 0.0 | 0.0 | Bone: formation by autoinduction. | M R Urist | Science | 1965 | 5319761 | Yes |
| 383 | 4267 | 4267.0 | 115.2 | 115.2 | The molecular heterogeneity of protein kinase C and its implications for cellular regulation. | Y Nishizuka | Nature | 1988 | 3045562 | No |
| 384 | 4266 | 4266.0 | 0.0 | 0.0 | The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. | T Nash | Biochem J | 1953 | 13105648 | Yes |
| 385 | 4258 | 4258.0 | 0.0 | 0.0 | Amino acid metabolism in mammalian cell cultures. | H Eagle | Science | 1959 | 13675766 | Yes |
| 386 | 4252 | 4252.0 | 116.1 | 116.1 | Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? | Kim A Brogden | Nat Rev Microbiol | 2005 | 15703760 | No |
| 387 | 12737 | 4245.7 | 1165.6 | 388.5 | MEGA11: Molecular Evolutionary Genetics Analysis Version 11. | Koichiro Tamura, Glen Stecher, Sudhir Kumar | Mol Biol Evol | 2021 | 33892491 | Yes |
| 388 | 16945 | 4236.2 | 719.8 | 179.9 | IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. | Lam-Tung Nguyen, Heiko A Schmidt, Arndt Von Haeseler, Bui Quang Minh | Mol Biol Evol | 2015 | 25371430 | Yes |
| 389 | 4236 | 4236.0 | 96.1 | 96.1 | Apoptosis by death factor. | S Nagata | Cell | 1997 | 9039262 | No |
| 390 | 16944 | 4236.0 | 401.0 | 100.2 | Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. | Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg | Genome Biol | 2009 | 19261174 | Yes |
| 391 | 4235 | 4235.0 | 100.1 | 100.1 | Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. | A H Wyllie | Nature | 1980 | 6245367 | Yes |
| 392 | 12690 | 4230.0 | 467.1 | 155.7 | Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. | W H Habig, M J Pabst, W B Jakoby | J Biol Chem | 1974 | 4436300 | Yes |
| 393 | 4227 | 4227.0 | 134.1 | 134.1 | Determination of protein: a modification of the Lowry method that gives a linear photometric response. | E F Hartree | Anal Biochem | 1972 | 4115981 | Yes |
| 394 | 4222 | 4222.0 | 97.9 | 97.9 | Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. | S Henikoff | Gene | 1984 | 6235151 | Yes |
| 395 | 16887 | 4221.8 | 991.6 | 247.9 | Rayyan-a web and mobile app for systematic reviews. | Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed Elmagarmid | Syst Rev | 2016 | 27919275 | Yes |
| 396 | 4218 | 4218.0 | 119.1 | 119.1 | Mesenchymal stem cells. | A I Caplan | J Orthop Res | 1991 | 1870029 | Yes |
| 397 | 4206 | 4206.0 | 89.4 | 89.4 | Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. | C J Marshall | Cell | 1995 | 7834738 | No |
| 398 | 4203 | 4203.0 | 132.4 | 132.4 | adegenet: a R package for the multivariate analysis of genetic markers. | Thibaut Jombart | Bioinformatics | 2008 | 18397895 | Yes |
| 399 | 4201 | 4201.0 | 0.0 | 0.0 | A relation between non-esterified fatty acids in plasma and the metabolism of glucose. | V P Dole | J Clin Invest | 1956 | 13286333 | Yes |
| 400 | 8401 | 4200.5 | 236.8 | 118.4 | Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. | Daniel E Voth, Robert A Heinzen | Cell Microbiol | 2007 | 17381428 | No |
| 401 | 8388 | 4194.0 | 232.4 | 116.2 | An integrative theory of prefrontal cortex function. | E K Miller, J D Cohen | Annu Rev Neurosci | 2001 | 11283309 | No |
| 402 | 4191 | 4191.0 | 173.4 | 173.4 | You want to measure coping but your protocol's too long: consider the brief COPE. | C S Carver | Int J Behav Med | 1997 | 16250744 | Yes |
| 403 | 12573 | 4191.0 | 314.8 | 104.9 | Understanding the Warburg effect: the metabolic requirements of cell proliferation. | Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson | Science | 2009 | 19460998 | No |
| 404 | 8381 | 4190.5 | 471.6 | 235.8 | The biology, function, and biomedical applications of exosomes. | Raghu Kalluri, Valerie S LeBleu | Science | 2020 | 32029601 | No |
| 405 | 37683 | 4187.0 | 864.0 | 96.0 | Cytoscape: a software environment for integrated models of biomolecular interaction networks. | Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker | Genome Res | 2003 | 14597658 | Yes |
| 406 | 4174 | 4174.0 | 155.7 | 155.7 | Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. | Russell A Barkley | Psychol Bull | 1997 | 9000892 | No |
| 407 | 4173 | 4173.0 | 0.0 | 0.0 | The determination of enzyme inhibitor constants. | M Dixon | Biochem J | 1953 | 13093635 | Yes |
| 408 | 8344 | 4172.0 | 214.3 | 107.2 | The basics of epithelial-mesenchymal transition. | Raghu Kalluri, Robert A Weinberg | J Clin Invest | 2009 | 19487818 | No |
| 409 | 4170 | 4170.0 | 102.3 | 102.3 | Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. | Ting-Chao Chou | Pharmacol Rev | 2006 | 16968952 | No |
| 410 | 4166 | 4166.0 | 104.0 | 104.0 | Multiple sequence alignment with hierarchical clustering. | F Corpet | Nucleic Acids Res | 1988 | 2849754 | Yes |
| 411 | 4165 | 4165.0 | 147.1 | 147.1 | Health promotion by social cognitive means. | Albert Bandura | Health Educ Behav | 2004 | 15090118 | Yes |
| 412 | 4164 | 4164.0 | 133.5 | 133.5 | Bacterial evolution. | C R Woese | Microbiol Rev | 1987 | 2439888 | No |
| 413 | 8284 | 4142.0 | 185.1 | 92.5 | Genomic sequencing. | G M Church, W Gilbert | Proc Natl Acad Sci U S A | 1984 | 6326095 | Yes |
| 414 | 8243 | 4121.5 | 292.3 | 146.2 | Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. | Laurent Excoffier, Heidi E L Lischer | Mol Ecol Resour | 2010 | 21565059 | Yes |
| 415 | 4110 | 4110.0 | 117.6 | 117.6 | Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. | R B D'Agostino | Stat Med | 1998 | 9802183 | Yes |
| 416 | 4094 | 4094.0 | 130.4 | 130.4 | What's wrong with Bonferroni adjustments. | T V Perneger | BMJ | 1998 | 9553006 | No |
| 417 | 4087 | 4087.0 | 146.4 | 146.4 | Psychometric properties of the strengths and difficulties questionnaire. | R Goodman | J Am Acad Child Adolesc Psychiatry | 2001 | 11699809 | Yes |
| 418 | 8167 | 4083.5 | 156.8 | 78.4 | Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. | A H Brand, N Perrimon | Development | 1993 | 8223268 | Yes |
| 419 | 12231 | 4077.0 | 248.5 | 82.8 | Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. | J F Kerr, A H Wyllie, A R Currie | Br J Cancer | 1972 | 4561027 | No |
| 420 | 4076 | 4076.0 | 91.9 | 91.9 | Instability and decay of the primary structure of DNA. | T Lindahl | Nature | 1993 | 8469282 | No |
| 421 | 4072 | 4072.0 | 113.3 | 113.3 | How do you feel? Interoception: the sense of the physiological condition of the body. | A D Craig | Nat Rev Neurosci | 2002 | 12154366 | No |
| 422 | 4072 | 4072.0 | 90.1 | 90.1 | Scaling and assessment of data quality. | Philip Evans | Acta Crystallogr D Biol Crystallogr | 2006 | 16369096 | No |
| 423 | 4070 | 4070.0 | 88.9 | 88.9 | Protein secondary structure prediction based on position-specific scoring matrices. | D T Jones | J Mol Biol | 1999 | 10493868 | Yes |
| 424 | 4058 | 4058.0 | 94.7 | 94.7 | Neural networks and physical systems with emergent collective computational abilities. | J J Hopfield | Proc Natl Acad Sci U S A | 1982 | 6953413 | Yes |
| 425 | 8109 | 4054.5 | 155.7 | 77.8 | A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. | R S Sikorski, P Hieter | Genetics | 1989 | 2659436 | Yes |
| 426 | 4040 | 4040.0 | 111.6 | 111.6 | The nuclear factor NF-kappaB pathway in inflammation. | Toby Lawrence | Cold Spring Harb Perspect Biol | 2009 | 20457564 | No |
| 427 | 8062 | 4031.0 | 235.7 | 117.8 | BEAST: Bayesian evolutionary analysis by sampling trees. | Alexei J Drummond, Andrew Rambaut | BMC Evol Biol | 2007 | 17996036 | Yes |
| 428 | 4027 | 4027.0 | 107.3 | 107.3 | Integrins: a family of cell surface receptors. | R O Hynes | Cell | 1987 | 3028640 | No |
| 429 | 4026 | 4026.0 | 110.5 | 110.5 | What is the evidence that tumors are angiogenesis dependent? | J Folkman | J Natl Cancer Inst | 1990 | 1688381 | No |
| 430 | 4026 | 4026.0 | 125.5 | 125.5 | Protective and damaging effects of stress mediators. | B S McEwen | N Engl J Med | 1998 | 9428819 | No |
| 431 | 8050 | 4025.0 | 202.9 | 101.5 | Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. | Weizhong Li, Adam Godzik | Bioinformatics | 2006 | 16731699 | Yes |
| 432 | 4020 | 4020.0 | 101.9 | 101.9 | Sequencing technologies - the next generation. | Michael L Metzker | Nat Rev Genet | 2010 | 19997069 | No |
| 433 | 8019 | 4009.5 | 257.1 | 128.6 | Complex network measures of brain connectivity: uses and interpretations. | Mikail Rubinov, Olaf Sporns | Neuroimage | 2010 | 19819337 | Yes |
| 434 | 8008 | 4004.0 | 326.2 | 163.1 | The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. | P F Lovibond, S H Lovibond | Behav Res Ther | 1995 | 7726811 | Yes |
| 435 | 4000 | 4000.0 | 134.6 | 134.6 | Tissue destruction by neutrophils. | S J Weiss | N Engl J Med | 1989 | 2536474 | No |
| 436 | 3990 | 3990.0 | 133.6 | 133.6 | genepop'007: a complete re-implementation of the genepop software for Windows and Linux. | Francois Rousset | Mol Ecol Resour | 2008 | 21585727 | Yes |
| 437 | 7961 | 3980.5 | 303.0 | 151.5 | Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. | R M Ryan, E L Deci | Am Psychol | 2000 | 11392867 | Yes |
| 438 | 3979 | 3979.0 | 0.0 | 0.0 | Staining of tissue sections for electron microscopy with heavy metals. | M L Watson | J Biophys Biochem Cytol | 1958 | 13563554 | Yes |
| 439 | 3962 | 3962.0 | 111.7 | 111.7 | Graphene: status and prospects. | A K Geim | Science | 2009 | 19541989 | Yes |
| 440 | 3961 | 3961.0 | 135.0 | 135.0 | Basic principles of ROC analysis. | C E Metz | Semin Nucl Med | 1978 | 112681 | Yes |
| 441 | 3957 | 3957.0 | 116.0 | 116.0 | The adolescent brain and age-related behavioral manifestations. | L P Spear | Neurosci Biobehav Rev | 2000 | 10817843 | No |
| 442 | 3947 | 3947.0 | 0.0 | 0.0 | Generalized expectancies for internal versus external control of reinforcement. | J B Rotter | Psychol Monogr | 1966 | 5340840 | No |
| 443 | 3942 | 3942.0 | 77.0 | 77.0 | Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. | G R Martin | Proc Natl Acad Sci U S A | 1981 | 6950406 | Yes |
| 444 | 3936 | 3936.0 | 130.7 | 130.7 | No adjustments are needed for multiple comparisons. | K J Rothman | Epidemiology | 1990 | 2081237 | Yes |
| 445 | 11806 | 3935.3 | 298.1 | 99.4 | Canonical sampling through velocity rescaling. | Giovanni Bussi, Davide Donadio, Michele Parrinello | J Chem Phys | 2007 | 17212484 | Yes |
| 446 | 3933 | 3933.0 | 98.5 | 98.5 | I-TASSER server for protein 3D structure prediction. | Yang Zhang | BMC Bioinformatics | 2008 | 18215316 | Yes |
| 447 | 3928 | 3928.0 | 129.0 | 129.0 | Nitric oxide as a secretory product of mammalian cells. | C Nathan | FASEB J | 1992 | 1381691 | No |
| 448 | 7852 | 3926.0 | 166.4 | 83.2 | Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. | H Aviv, P Leder | Proc Natl Acad Sci U S A | 1972 | 4504350 | Yes |
| 449 | 3923 | 3923.0 | 90.0 | 90.0 | Novel proteinaceous infectious particles cause scrapie. | S B Prusiner | Science | 1982 | 6801762 | Yes |
| 450 | 11761 | 3920.3 | 335.2 | 111.7 | GSVA: gene set variation analysis for microarray and RNA-seq data. | Sonja Hanzelmann, Robert Castelo, Justin Guinney | BMC Bioinformatics | 2013 | 23323831 | Yes |
| 451 | 3917 | 3917.0 | 0.0 | 0.0 | Disc Electrophoresis. I. Background And Theory. | L Ornstein | Ann N Y Acad Sci | 1964 | 14240533 | Yes |
| 452 | 3910 | 3910.0 | 105.9 | 105.9 | Non-coding RNAs in human disease. | Manel Esteller | Nat Rev Genet | 2011 | 22094949 | No |
| 453 | 3904 | 3904.0 | 103.4 | 103.4 | The pathobiology of diabetic complications: a unifying mechanism. | Michael Brownlee | Diabetes | 2005 | 15919781 | No |
| 454 | 3888 | 3888.0 | 97.8 | 97.8 | Caspases: the executioners of apoptosis. | G M Cohen | Biochem J | 1997 | 9337844 | No |
| 455 | 3878 | 3878.0 | 104.4 | 104.4 | Preparation of isolated rat liver cells. | P O Seglen | Methods Cell Biol | 1976 | 177845 | No |
| 456 | 7743 | 3871.5 | 299.3 | 149.7 | Microsomal lipid peroxidation. | J A Buege, S D Aust | Methods Enzymol | 1978 | 672633 | Yes |
| 457 | 7742 | 3871.0 | 640.3 | 320.1 | Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2021 | 33885785 | Yes |
| 458 | 3862 | 3862.0 | 179.7 | 179.7 | The quality of care. How can it be assessed? | A Donabedian | JAMA | 1988 | 3045356 | No |
| 459 | 3856 | 3856.0 | 137.9 | 137.9 | Role of nrf2 in oxidative stress and toxicity. | Qiang Ma | Annu Rev Pharmacol Toxicol | 2013 | 23294312 | No |
| 460 | 11548 | 3849.3 | 284.3 | 94.8 | ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. | Kai Wang, Mingyao Li, Hakon Hakonarson | Nucleic Acids Res | 2010 | 20601685 | Yes |
| 461 | 3847 | 3847.0 | 116.9 | 116.9 | Efficient methods to compute genomic predictions. | P M VanRaden | J Dairy Sci | 2008 | 18946147 | Yes |
| 462 | 3845 | 3845.0 | 111.6 | 111.6 | Revisions in the International System for Staging Lung Cancer. | C F Mountain | Chest | 1997 | 9187198 | Yes |
| 463 | 3841 | 3841.0 | 0.0 | 0.0 | Pharmacological implications of microsomal enzyme induction. | A H Conney | Pharmacol Rev | 1967 | 4383307 | Yes |
| 464 | 3841 | 3841.0 | 150.7 | 150.7 | Microplastics in the marine environment. | Anthony L Andrady | Mar Pollut Bull | 2011 | 21742351 | No |
| 465 | 3832 | 3832.0 | 157.6 | 157.6 | Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. | Joseph P Weir | J Strength Cond Res | 2005 | 15705040 | No |
| 466 | 3824 | 3824.0 | 130.0 | 130.0 | The Danish Civil Registration System. | Carsten Bocker Pedersen | Scand J Public Health | 2011 | 21775345 | Yes |
| 467 | 7643 | 3821.5 | 195.0 | 97.5 | Mitochondria and apoptosis. | D R Green, J C Reed | Science | 1998 | 9721092 | No |
| 468 | 3816 | 3816.0 | 81.6 | 81.6 | TGF-beta signal transduction. | J Massague | Annu Rev Biochem | 1998 | 9759503 | No |
| 469 | 3813 | 3813.0 | 93.7 | 93.7 | Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. | A T Brunger | Nature | 1992 | 18481394 | Yes |
| 470 | 7617 | 3808.5 | 174.8 | 87.4 | Functional rafts in cell membranes. | K Simons, E Ikonen | Nature | 1997 | 9177342 | No |
| 471 | 3804 | 3804.0 | 79.1 | 79.1 | A catalogue of splice junction sequences. | S M Mount | Nucleic Acids Res | 1982 | 7063411 | Yes |
| 472 | 41734 | 3794.0 | 911.5 | 82.9 | Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. | Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov | Proc Natl Acad Sci U S A | 2005 | 16199517 | Yes |
| 473 | 3792 | 3792.0 | 160.0 | 160.0 | Statistics corner: A guide to appropriate use of correlation coefficient in medical research. | M M Mukaka | Malawi Med J | 2012 | 23638278 | Yes |
| 474 | 11360 | 3786.7 | 280.7 | 93.6 | Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nucleic Acids Res | 2009 | 19033363 | Yes |
| 475 | 3763 | 3763.0 | 82.0 | 82.0 | Profile hidden Markov models. | S R Eddy | Bioinformatics | 1998 | 9918945 | No |
| 476 | 3759 | 3759.0 | 0.0 | 0.0 | Estimation of the molecular weights of proteins by Sephadex gel-filtration. | P Andrews | Biochem J | 1964 | 4158310 | Yes |
| 477 | 18793 | 3758.6 | 733.9 | 146.8 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | Ann Intern Med | 2009 | 19622511 | No |
| 478 | 3755 | 3755.0 | 108.7 | 108.7 | Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. | J H Morrissey | Anal Biochem | 1981 | 6172996 | Yes |
| 479 | 3747 | 3747.0 | 66.9 | 66.9 | Somatic generation of antibody diversity. | S Tonegawa | Nature | 1983 | 6300689 | No |
| 480 | 3740 | 3740.0 | 180.8 | 180.8 | Toward understanding the origin and evolution of cellular organisms. | Minoru Kanehisa | Protein Sci | 2019 | 31441146 | No |
| 481 | 11203 | 3734.3 | 217.3 | 72.4 | Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. | J D Dignam, R M Lebovitz, R G Roeder | Nucleic Acids Res | 1983 | 6828386 | Yes |
| 482 | 7446 | 3723.0 | 222.6 | 111.3 | Complex brain networks: graph theoretical analysis of structural and functional systems. | Ed Bullmore, Olaf Sporns | Nat Rev Neurosci | 2009 | 19190637 | No |
| 483 | 3722 | 3722.0 | 108.1 | 108.1 | Biological roles of oligosaccharides: all of the theories are correct. | A Varki | Glycobiology | 1993 | 8490246 | No |
| 484 | 3722 | 3722.0 | 131.7 | 131.7 | Modeling valuations for EuroQol health states. | P Dolan | Med Care | 1997 | 9366889 | Yes |
| 485 | 7426 | 3713.0 | 176.7 | 88.3 | Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. | C Tuerk, L Gold | Science | 1990 | 2200121 | Yes |
| 486 | 3705 | 3705.0 | 0.0 | 0.0 | A membrane-filter technique for the detection of complementary DNA. | D T Denhardt | Biochem Biophys Res Commun | 1966 | 5963888 | Yes |
| 487 | 3705 | 3705.0 | 91.4 | 91.4 | Glutamate uptake. | N C Danbolt | Prog Neurobiol | 2001 | 11369436 | No |
| 488 | 7368 | 3684.0 | 222.6 | 111.3 | Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. | Jeng-Da Chai, Martin Head-Gordon | Phys Chem Chem Phys | 2008 | 18989472 | Yes |
| 489 | 3683 | 3683.0 | 0.0 | 0.0 | The magical number seven plus or minus two: some limits on our capacity for processing information. | G A Miller | Psychol Rev | 1956 | 13310704 | Yes |
| 490 | 7361 | 3680.5 | 0.0 | 0.0 | Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. | D H Hubel, T N Wiesel | J Physiol | 1962 | 14449617 | Yes |
| 491 | 3674 | 3674.0 | 130.1 | 130.1 | Estimation of average heterozygosity and genetic distance from a small number of individuals. | M Nei | Genetics | 1978 | 17248844 | Yes |
| 492 | 7346 | 3673.0 | 138.3 | 69.2 | Translating the histone code. | T Jenuwein, C D Allis | Science | 2001 | 11498575 | No |
| 493 | 3670 | 3670.0 | 137.9 | 137.9 | Essential oils: their antibacterial properties and potential applications in foods--a review. | Sara Burt | Int J Food Microbiol | 2004 | 15246235 | No |
| 494 | 3663 | 3663.0 | 132.2 | 132.2 | Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. | O W Griffith | Anal Biochem | 1980 | 7416462 | Yes |
| 495 | 3663 | 3663.0 | 162.9 | 162.9 | Hepatocellular Carcinoma. | Augusto Villanueva | N Engl J Med | 2019 | 30970190 | No |
| 496 | 3654 | 3654.0 | 99.4 | 99.4 | The basis of anisotropic water diffusion in the nervous system - a technical review. | Christian Beaulieu | NMR Biomed | 2002 | 12489094 | No |
| 497 | 3653 | 3653.0 | 77.6 | 77.6 | Mammalian neural stem cells. | F H Gage | Science | 2000 | 10688783 | No |
| 498 | 3653 | 3653.0 | 89.2 | 89.2 | Nonalcoholic fatty liver disease. | Paul Angulo | N Engl J Med | 2002 | 11961152 | No |
| 499 | 7301 | 3650.5 | 227.3 | 113.7 | The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. | Stephen B Edge, Carolyn C Compton | Ann Surg Oncol | 2010 | 20180029 | No |
| 500 | 7300 | 3650.0 | 148.3 | 74.2 | Statistical significance for genomewide studies. | John D Storey, Robert Tibshirani | Proc Natl Acad Sci U S A | 2003 | 12883005 | Yes |
| 501 | 3643 | 3643.0 | 60.8 | 60.8 | Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. | J D Rowley | Nature | 1973 | 4126434 | Yes |
| 502 | 3641 | 3641.0 | 90.4 | 90.4 | Marrow stromal cells as stem cells for nonhematopoietic tissues. | D J Prockop | Science | 1997 | 9082988 | No |
| 503 | 3639 | 3639.0 | 72.8 | 72.8 | Signal transduction by the JNK group of MAP kinases. | R J Davis | Cell | 2000 | 11057897 | No |
| 504 | 3634 | 3634.0 | 114.3 | 114.3 | Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. | L R Squire | Psychol Rev | 1992 | 1594723 | No |
| 505 | 3634 | 3634.0 | 80.5 | 80.5 | Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. | H F Dvorak | N Engl J Med | 1986 | 3537791 | No |
| 506 | 18161 | 3632.2 | 687.7 | 137.5 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | BMJ | 2009 | 19622551 | No |
| 507 | 7246 | 3623.0 | 0.0 | 0.0 | The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. | R C Graham, M J Karnovsky | J Histochem Cytochem | 1966 | 5962951 | Yes |
| 508 | 3620 | 3620.0 | 133.9 | 133.9 | Social cognitive theory: an agentic perspective. | A Bandura | Annu Rev Psychol | 2001 | 11148297 | Yes |
| 509 | 3605 | 3605.0 | 97.7 | 97.7 | Microglia: a sensor for pathological events in the CNS. | G W Kreutzberg | Trends Neurosci | 1996 | 8843599 | No |
| 510 | 3603 | 3603.0 | 92.3 | 92.3 | Cellular and molecular mechanisms of fibrosis. | T A Wynn | J Pathol | 2008 | 18161745 | No |
| 511 | 3600 | 3600.0 | 112.0 | 112.0 | Inositol trisphosphate and diacylglycerol as second messengers. | M J Berridge | Biochem J | 1984 | 6146314 | No |
| 512 | 3598 | 3598.0 | 86.5 | 86.5 | Mitochondrial formation of reactive oxygen species. | Julio F Turrens | J Physiol | 2003 | 14561818 | No |
| 513 | 3597 | 3597.0 | 114.3 | 114.3 | The free-energy principle: a unified brain theory? | Karl Friston | Nat Rev Neurosci | 2010 | 20068583 | No |
| 514 | 7189 | 3594.5 | 209.0 | 104.5 | Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. | C Beauchamp, I Fridovich | Anal Biochem | 1971 | 4943714 | Yes |
| 515 | 3591 | 3591.0 | 194.2 | 194.2 | Obesity: global epidemiology and pathogenesis. | Matthias Bluher | Nat Rev Endocrinol | 2019 | 30814686 | No |
| 516 | 21487 | 3581.2 | 1066.7 | 177.8 | DADA2: High-resolution sample inference from Illumina amplicon data. | Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P Holmes | Nat Methods | 2016 | 27214047 | Yes |
| 517 | 7152 | 3576.0 | 190.3 | 95.2 | The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. | Taro Kawai, Shizuo Akira | Nat Immunol | 2010 | 20404851 | No |
| 518 | 3575 | 3575.0 | 90.2 | 90.2 | The heat-shock response. | S Lindquist | Annu Rev Biochem | 1986 | 2427013 | No |
| 519 | 10718 | 3572.7 | 319.9 | 106.6 | FastTree 2--approximately maximum-likelihood trees for large alignments. | Morgan N Price, Paramvir S Dehal, Adam P Arkin | PLoS One | 2010 | 20224823 | Yes |
| 520 | 7144 | 3572.0 | 140.2 | 70.1 | The ubiquitin system. | A Hershko, A Ciechanover | Annu Rev Biochem | 1998 | 9759494 | No |
| 521 | 7137 | 3568.5 | 177.2 | 88.6 | Exploring the full spectrum of macrophage activation. | David M Mosser, Justin P Edwards | Nat Rev Immunol | 2008 | 19029990 | No |
| 522 | 3562 | 3562.0 | 77.0 | 77.0 | Alzheimer's disease is a synaptic failure. | Dennis J Selkoe | Science | 2002 | 12399581 | No |
| 523 | 28481 | 3560.1 | 666.8 | 83.3 | The Protein Data Bank. | H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne | Nucleic Acids Res | 2000 | 10592235 | Yes |
| 524 | 7083 | 3541.5 | 144.5 | 72.2 | A new method for sequencing DNA. | A M Maxam, W Gilbert | Proc Natl Acad Sci U S A | 1977 | 265521 | Yes |
| 525 | 7082 | 3541.0 | 238.1 | 119.0 | Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. | K Tamura, M Nei | Mol Biol Evol | 1993 | 8336541 | Yes |
| 526 | 3541 | 3541.0 | 78.9 | 78.9 | Cardiac excitation-contraction coupling. | Donald M Bers | Nature | 2002 | 11805843 | No |
| 527 | 3540 | 3540.0 | 97.3 | 97.3 | Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. | R W Mahley | Science | 1988 | 3283935 | No |
| 528 | 3538 | 3538.0 | 122.0 | 122.0 | What is value in health care? | Michael E Porter | N Engl J Med | 2010 | 21142528 | Yes |
| 529 | 3533 | 3533.0 | 0.0 | 0.0 | Spectroscopic determination of tryptophan and tyrosine in proteins. | H Edelhoch | Biochemistry | 1967 | 6049437 | Yes |
| 530 | 7063 | 3531.5 | 206.4 | 103.2 | Projections of global mortality and burden of disease from 2002 to 2030. | Colin D Mathers, Dejan Loncar | PLoS Med | 2006 | 17132052 | Yes |
| 531 | 3528 | 3528.0 | 0.0 | 0.0 | The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. | J F Woessner | Arch Biochem Biophys | 1961 | 13786180 | Yes |
| 532 | 17611 | 3522.2 | 500.3 | 100.1 | Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. | O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth | Pflugers Arch | 1981 | 6270629 | Yes |
| 533 | 3519 | 3519.0 | 187.4 | 187.4 | Conservation of resources. A new attempt at conceptualizing stress. | S E Hobfoll | Am Psychol | 1989 | 2648906 | No |
| 534 | 3519 | 3519.0 | 92.9 | 92.9 | Biologic basis for interleukin-1 in disease. | C A Dinarello | Blood | 1996 | 8630372 | No |
| 535 | 3517 | 3517.0 | 70.2 | 70.2 | The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. | Isaiah J Fidler | Nat Rev Cancer | 2003 | 12778135 | No |
| 536 | 3508 | 3508.0 | 108.6 | 108.6 | Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. | Thomas Welton | Chem Rev | 1999 | 11849019 | Yes |
| 537 | 7005 | 3502.5 | 158.8 | 79.4 | Angiogenesis in cancer and other diseases. | P Carmeliet, R K Jain | Nature | 2000 | 11001068 | No |
| 538 | 3498 | 3498.0 | 89.5 | 89.5 | Wound healing--aiming for perfect skin regeneration. | P Martin | Science | 1997 | 9082989 | No |
| 539 | 6992 | 3496.0 | 158.9 | 79.5 | Electrochemical photolysis of water at a semiconductor electrode. | A Fujishima, K Honda | Nature | 1972 | 12635268 | Yes |
| 540 | 6987 | 3493.5 | 199.4 | 99.7 | Velvet: algorithms for de novo short read assembly using de Bruijn graphs. | Daniel R Zerbino, Ewan Birney | Genome Res | 2008 | 18349386 | Yes |
| 541 | 6982 | 3491.0 | 200.6 | 100.3 | mTOR signaling in growth control and disease. | Mathieu Laplante, David M Sabatini | Cell | 2012 | 22500797 | No |
| 542 | 3487 | 3487.0 | 0.0 | 0.0 | A Rationale And Test For The Number Of Factors In Factor Analysis. | J L Horn | Psychometrika | 1965 | 14306381 | Yes |
| 543 | 3484 | 3484.0 | 0.0 | 0.0 | Statistical estimations in enzyme kinetics. | G N Wilkinson | Biochem J | 1961 | 13785321 | Yes |
| 544 | 3476 | 3476.0 | 96.4 | 96.4 | Hay fever, hygiene, and household size. | D P Strachan | BMJ | 1989 | 2513902 | Yes |
| 545 | 10423 | 3474.3 | 544.1 | 181.4 | Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. | P J Van Soest, J B Robertson, B A Lewis | J Dairy Sci | 1991 | 1660498 | No |
| 546 | 3473 | 3473.0 | 75.2 | 75.2 | Protein folding and misfolding. | Christopher M Dobson | Nature | 2003 | 14685248 | No |
| 547 | 6939 | 3469.5 | 266.5 | 133.2 | Measuring agreement in method comparison studies. | J M Bland, D G Altman | Stat Methods Med Res | 1999 | 10501650 | No |
| 548 | 10381 | 3460.3 | 322.3 | 107.4 | Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. | G Evanno, S Regnaut, J Goudet | Mol Ecol | 2005 | 15969739 | Yes |
| 549 | 6919 | 3459.5 | 297.8 | 148.9 | GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. | Rod Peakall, Peter E Smouse | Bioinformatics | 2012 | 22820204 | Yes |
| 550 | 3452 | 3452.0 | 85.2 | 85.2 | Modularity and community structure in networks. | M E J Newman | Proc Natl Acad Sci U S A | 2006 | 16723398 | Yes |
| 551 | 6895 | 3447.5 | 168.1 | 84.0 | In vitro selection of RNA molecules that bind specific ligands. | A D Ellington, J W Szostak | Nature | 1990 | 1697402 | Yes |
| 552 | 6879 | 3439.5 | 169.6 | 84.8 | "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. | A P Feinberg, B Vogelstein | Anal Biochem | 1984 | 6329026 | Yes |
| 553 | 3439 | 3439.0 | 0.0 | 0.0 | Some factors in the interpretation of protein denaturation. | W Kauzmann | Adv Protein Chem | 1959 | 14404936 | Yes |
| 554 | 6871 | 3435.5 | 0.0 | 0.0 | The serial cultivation of human diploid cell strains. | L Hayflick, P S Moorhead | Exp Cell Res | 1961 | 13905658 | Yes |
| 555 | 3425 | 3425.0 | 119.4 | 119.4 | The biology and function of fibroblasts in cancer. | Raghu Kalluri | Nat Rev Cancer | 2016 | 27550820 | No |
| 556 | 6845 | 3422.5 | 177.6 | 88.8 | Human malaria parasites in continuous culture. | W Trager, J B Jensen | Science | 1976 | 781840 | Yes |
| 557 | 6826 | 3413.0 | 0.0 | 0.0 | Pain mechanisms: a new theory. | R Melzack, P D Wall | Science | 1965 | 5320816 | No |
| 558 | 3412 | 3412.0 | 111.3 | 111.3 | Transformed up-down methods in psychoacoustics. | H Levitt | J Acoust Soc Am | 1971 | 5541744 | Yes |
| 559 | 6824 | 3412.0 | 178.7 | 89.3 | Pattern recognition receptors and inflammation. | Osamu Takeuchi, Shizuo Akira | Cell | 2010 | 20303872 | No |
| 560 | 10233 | 3411.0 | 445.7 | 148.6 | Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. | J L Cox, J M Holden, R Sagovsky | Br J Psychiatry | 1987 | 3651732 | Yes |
| 561 | 3405 | 3405.0 | 78.8 | 78.8 | Tolerance, danger, and the extended family. | P Matzinger | Annu Rev Immunol | 1994 | 8011301 | No |
| 562 | 3404 | 3404.0 | 85.6 | 85.6 | Photoelectrochemical cells. | M Gratzel | Nature | 2001 | 11713540 | Yes |
| 563 | 6800 | 3400.0 | 176.2 | 88.1 | TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. | T R Mosmann, R L Coffman | Annu Rev Immunol | 1989 | 2523712 | No |
| 564 | 3400 | 3400.0 | 119.0 | 119.0 | Development of a classification system for periodontal diseases and conditions. | G C Armitage | Ann Periodontol | 1999 | 10863370 | No |
| 565 | 3399 | 3399.0 | 78.6 | 78.6 | Calcium signaling. | David E Clapham | Cell | 2007 | 18083096 | No |
| 566 | 3395 | 3395.0 | 78.5 | 78.5 | T cell exhaustion. | E John Wherry | Nat Immunol | 2011 | 21739672 | No |
| 567 | 10181 | 3393.7 | 199.9 | 66.6 | Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. | Ron Edgar, Michael Domrachev, Alex E Lash | Nucleic Acids Res | 2002 | 11752295 | Yes |
| 568 | 3391 | 3391.0 | 87.4 | 87.4 | Recent advances with liposomes as pharmaceutical carriers. | Vladimir P Torchilin | Nat Rev Drug Discov | 2005 | 15688077 | No |
| 569 | 3386 | 3386.0 | 126.9 | 126.9 | The processing-speed theory of adult age differences in cognition. | T A Salthouse | Psychol Rev | 1996 | 8759042 | No |
| 570 | 10154 | 3384.7 | 0.0 | 0.0 | The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. | F C Greenwood, W M Hunter, J S Glover | Biochem J | 1963 | 14097352 | Yes |
| 571 | 3384 | 3384.0 | 80.8 | 80.8 | The dendritic cell system and its role in immunogenicity. | R M Steinman | Annu Rev Immunol | 1991 | 1910679 | No |
| 572 | 3380 | 3380.0 | 158.8 | 158.8 | Measurement of pain. | E C Huskisson | Lancet | 1974 | 4139420 | Yes |
| 573 | 3380 | 3380.0 | 107.7 | 107.7 | Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. | Y X Fu | Genetics | 1997 | 9335623 | Yes |
| 574 | 3379 | 3379.0 | 65.0 | 65.0 | Cell signaling by receptor tyrosine kinases. | J Schlessinger | Cell | 2000 | 11057895 | No |
| 575 | 3379 | 3379.0 | 98.0 | 98.0 | Parkinson's disease: clinical features and diagnosis. | J Jankovic | J Neurol Neurosurg Psychiatry | 2008 | 18344392 | No |
| 576 | 3377 | 3377.0 | 95.3 | 95.3 | The unfolded protein response: controlling cell fate decisions under ER stress and beyond. | Claudio Hetz | Nat Rev Mol Cell Biol | 2012 | 22251901 | No |
| 577 | 3374 | 3374.0 | 82.3 | 82.3 | The resurgence of platinum-based cancer chemotherapy. | Lloyd Kelland | Nat Rev Cancer | 2007 | 17625587 | No |
| 578 | 3370 | 3370.0 | 70.1 | 70.1 | The scanning model for translation: an update. | M Kozak | J Cell Biol | 1989 | 2645293 | No |
| 579 | 3355 | 3355.0 | 98.6 | 98.6 | A rating instrument for anxiety disorders. | W W Zung | Psychosomatics | 1971 | 5172928 | Yes |
| 580 | 3353 | 3353.0 | 139.8 | 139.8 | Half a century of research on the Stroop effect: an integrative review. | C M MacLeod | Psychol Bull | 1991 | 2034749 | No |
| 581 | 6705 | 3352.5 | 322.4 | 161.2 | Stress, social support, and the buffering hypothesis. | S Cohen, T A Wills | Psychol Bull | 1985 | 3901065 | No |
| 582 | 3348 | 3348.0 | 143.3 | 143.3 | Measures of reliability in sports medicine and science. | W G Hopkins | Sports Med | 2000 | 10907753 | Yes |
| 583 | 3347 | 3347.0 | 72.8 | 72.8 | TGFbeta in Cancer. | Joan Massague | Cell | 2008 | 18662538 | No |
| 584 | 3345 | 3345.0 | 93.1 | 93.1 | ABC transporters: from microorganisms to man. | C F Higgins | Annu Rev Cell Biol | 1992 | 1282354 | No |
| 585 | 6688 | 3344.0 | 188.7 | 94.3 | Voxel-based morphometry--the methods. | J Ashburner, K J Friston | Neuroimage | 2000 | 10860804 | No |
| 586 | 3342 | 3342.0 | 71.1 | 71.1 | Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. | M Kozak | Nucleic Acids Res | 1984 | 6694911 | Yes |
| 587 | 3333 | 3333.0 | 86.1 | 86.1 | Lead- and drug-like compounds: the rule-of-five revolution. | Christopher A Lipinski | Drug Discov Today Technol | 2004 | 24981612 | Yes |
| 588 | 13325 | 3331.2 | 513.1 | 128.3 | APACHE II: a severity of disease classification system. | W A Knaus, E A Draper, D P Wagner, J E Zimmerman | Crit Care Med | 1985 | 3928249 | Yes |
| 589 | 3327 | 3327.0 | 128.9 | 128.9 | Central sensitization: implications for the diagnosis and treatment of pain. | Clifford J Woolf | Pain | 2011 | 20961685 | No |
| 590 | 3303 | 3303.0 | 86.5 | 86.5 | Gene regulation by steroid hormones. | M Beato | Cell | 1989 | 2644044 | No |
| 591 | 3301 | 3301.0 | 0.0 | 0.0 | Equilibrium Ultracentrifugation Of Dilute Solutions. | D A Yphantis | Biochemistry | 1964 | 14155091 | Yes |
| 592 | 3299 | 3299.0 | 146.0 | 146.0 | Abiotic Stress Signaling and Responses in Plants. | Jian-Kang Zhu | Cell | 2016 | 27716505 | No |
| 593 | 13195 | 3298.8 | 408.2 | 102.0 | Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. | Qiong Wang, George M Garrity, James M Tiedje, James R Cole | Appl Environ Microbiol | 2007 | 17586664 | Yes |
| 594 | 3295 | 3295.0 | 64.4 | 64.4 | Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. | P Schuck | Biophys J | 2000 | 10692345 | Yes |
| 595 | 3295 | 3295.0 | 71.8 | 71.8 | Angiogenesis in health and disease. | Peter Carmeliet | Nat Med | 2003 | 12778163 | No |
| 596 | 3285 | 3285.0 | 75.2 | 75.2 | Activators and target genes of Rel/NF-kappaB transcription factors. | H L Pahl | Oncogene | 1999 | 10602461 | No |
| 597 | 9846 | 3282.0 | 260.9 | 87.0 | Regularization Paths for Generalized Linear Models via Coordinate Descent. | Jerome Friedman, Trevor Hastie, Rob Tibshirani | J Stat Softw | 2010 | 20808728 | Yes |
| 598 | 6562 | 3281.0 | 186.8 | 93.4 | Unified segmentation. | John Ashburner, Karl J Friston | Neuroimage | 2005 | 15955494 | Yes |
| 599 | 3273 | 3273.0 | 67.0 | 67.0 | STATs and gene regulation. | J E Darnell | Science | 1997 | 9287210 | No |
| 600 | 3273 | 3273.0 | 118.5 | 118.5 | The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. | B L Fredrickson | Am Psychol | 2001 | 11315248 | Yes |
| 601 | 3270 | 3270.0 | 69.2 | 69.2 | CpG-rich islands and the function of DNA methylation. | A P Bird | Nature | 1986 | 2423876 | No |
| 602 | 3268 | 3268.0 | 150.5 | 150.5 | The short-form McGill Pain Questionnaire. | Ronald Melzack | Pain | 1987 | 3670870 | Yes |
| 603 | 3258 | 3258.0 | 0.0 | 0.0 | Gene action in the X-chromosome of the mouse (Mus musculus L.). | M F Lyon | Nature | 1961 | 13764598 | Yes |
| 604 | 6505 | 3252.5 | 158.9 | 79.5 | Oxidants, oxidative stress and the biology of ageing. | T Finkel, N J Holbrook | Nature | 2000 | 11089981 | No |
| 605 | 6504 | 3252.0 | 118.4 | 59.2 | The language of covalent histone modifications. | B D Strahl, C D Allis | Nature | 2000 | 10638745 | Yes |
| 606 | 6493 | 3246.5 | 143.5 | 71.8 | Toll-like receptor signalling. | Shizuo Akira, Kiyoshi Takeda | Nat Rev Immunol | 2004 | 15229469 | No |
| 607 | 3246 | 3246.0 | 84.7 | 84.7 | MapChart: software for the graphical presentation of linkage maps and QTLs. | R E Voorrips | J Hered | 2002 | 12011185 | Yes |
| 608 | 3245 | 3245.0 | 96.6 | 96.6 | Inositol trisphosphate and diacylglycerol: two interacting second messengers. | M J Berridge | Annu Rev Biochem | 1987 | 3304132 | No |
| 609 | 12979 | 3244.8 | 309.8 | 77.5 | Improved methods for building protein models in electron density maps and the location of errors in these models. | T A Jones, J Y Zou, S W Cowan, M Kjeldgaard | Acta Crystallogr A | 1991 | 2025413 | Yes |
| 610 | 6476 | 3238.0 | 144.8 | 72.4 | Emergence of scaling in random networks | A L Barabasi, R Albert | Science | 1999 | 10521342 | Yes |
| 611 | 3238 | 3238.0 | 73.4 | 73.4 | Mechanisms of angiogenesis and arteriogenesis. | P Carmeliet | Nat Med | 2000 | 10742145 | No |
| 612 | 3237 | 3237.0 | 83.5 | 83.5 | Obesity as a medical problem. | P G Kopelman | Nature | 2000 | 10766250 | No |
| 613 | 3228 | 3228.0 | 91.2 | 91.2 | Hepatocellular carcinoma. | Hashem B El-Serag | N Engl J Med | 2011 | 21992124 | No |
| 614 | 3225 | 3225.0 | 74.6 | 74.6 | Autophagy: process and function. | Noboru Mizushima | Genes Dev | 2007 | 18006683 | No |
| 615 | 9650 | 3216.7 | 208.7 | 69.6 | Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. | Benjamin P Lewis, Christopher B Burge, David P Bartel | Cell | 2005 | 15652477 | Yes |
| 616 | 3216 | 3216.0 | 142.6 | 142.6 | Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. | T E Moffitt | Psychol Rev | 1993 | 8255953 | No |
| 617 | 9636 | 3212.0 | 491.2 | 163.7 | SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. | Antoine Daina, Olivier Michielin, Vincent Zoete | Sci Rep | 2017 | 28256516 | Yes |
| 618 | 6413 | 3206.5 | 0.0 | 0.0 | A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. | S Reitman, S Frankel | Am J Clin Pathol | 1957 | 13458125 | Yes |
| 619 | 6404 | 3202.0 | 157.5 | 78.8 | Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. | T C Chou, P Talalay | Adv Enzyme Regul | 1984 | 6382953 | Yes |
| 620 | 3202 | 3202.0 | 103.1 | 103.1 | Doxil®--the first FDA-approved nano-drug: lessons learned. | Yechezkel Barenholz | J Control Release | 2012 | 22484195 | No |
| 621 | 6402 | 3201.0 | 209.6 | 104.8 | Extracellular vesicles: exosomes, microvesicles, and friends. | Graca Raposo, Willem Stoorvogel | J Cell Biol | 2013 | 23420871 | No |
| 622 | 6396 | 3198.0 | 147.4 | 73.7 | MicroRNA signatures in human cancers. | George A Calin, Carlo M Croce | Nat Rev Cancer | 2006 | 17060945 | No |
| 623 | 3188 | 3188.0 | 101.8 | 101.8 | Estimation of metabolite concentrations from localized in vivo proton NMR spectra. | S W Provencher | Magn Reson Med | 1993 | 8139448 | Yes |
| 624 | 3187 | 3187.0 | 76.2 | 76.2 | Optimal two-stage designs for phase II clinical trials. | R Simon | Control Clin Trials | 1989 | 2702835 | Yes |
| 625 | 3181 | 3181.0 | 76.4 | 76.4 | WHAT IF: a molecular modeling and drug design program. | G Vriend | J Mol Graph | 1990 | 2268628 | Yes |
| 626 | 3171 | 3171.0 | 109.2 | 109.2 | Large-scale brain networks and psychopathology: a unifying triple network model. | Vinod Menon | Trends Cogn Sci | 2011 | 21908230 | No |
| 627 | 3169 | 3169.0 | 147.0 | 147.0 | The antibiotic resistance crisis: part 1: causes and threats. | C Lee Ventola | P T | 2015 | 25859123 | Yes |
| 628 | 3168 | 3168.0 | 80.0 | 80.0 | The transforming growth factor-beta family. | J Massague | Annu Rev Cell Biol | 1990 | 2177343 | No |
| 629 | 9466 | 3155.3 | 225.8 | 75.3 | The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. | R C Lee, R L Feinbaum, V Ambros | Cell | 1993 | 8252621 | Yes |
| 630 | 6308 | 3154.0 | 216.9 | 108.5 | Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. | S Marklund, G Marklund | Eur J Biochem | 1974 | 4215654 | Yes |
| 631 | 6296 | 3148.0 | 195.3 | 97.7 | Nonparametric statistical testing of EEG- and MEG-data. | Eric Maris, Robert Oostenveld | J Neurosci Methods | 2007 | 17517438 | Yes |
| 632 | 3147 | 3147.0 | 96.9 | 96.9 | Stress, adaptation, and disease. Allostasis and allostatic load. | B S McEwen | Ann N Y Acad Sci | 1998 | 9629234 | No |
| 633 | 3143 | 3143.0 | 0.0 | 0.0 | Diffusion-in-gel methods for immunological analysis. | O Ouchterlony | Prog Allergy | 1958 | 13578996 | Yes |
| 634 | 9427 | 3142.3 | 323.1 | 107.7 | Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. | R A Deyo, D C Cherkin, M A Ciol | J Clin Epidemiol | 1992 | 1607900 | Yes |
| 635 | 6278 | 3139.0 | 138.9 | 69.5 | Inflammation and cancer: back to Virchow? | F Balkwill, A Mantovani | Lancet | 2001 | 11229684 | No |
| 636 | 3139 | 3139.0 | 135.3 | 135.3 | What's in a name? Qualitative description revisited. | Margarete Sandelowski | Res Nurs Health | 2010 | 20014004 | Yes |
| 637 | 3130 | 3130.0 | 100.8 | 100.8 | Colorimetric assay of catalase. | A K Sinha | Anal Biochem | 1972 | 4556490 | Yes |
| 638 | 3130 | 3130.0 | 86.6 | 86.6 | Dietary pattern analysis: a new direction in nutritional epidemiology. | Frank B Hu | Curr Opin Lipidol | 2002 | 11790957 | No |
| 639 | 9380 | 3126.7 | 323.5 | 107.8 | Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. | R M Palmer, A G Ferrige, S Moncada | Nature | 1987 | 3495737 | Yes |
| 640 | 12506 | 3126.5 | 312.7 | 78.2 | Haploview: analysis and visualization of LD and haplotype maps. | J C Barrett, B Fry, J Maller, M J Daly | Bioinformatics | 2005 | 15297300 | Yes |
| 641 | 3126 | 3126.0 | 108.9 | 108.9 | SF-36 health survey update. | J E Ware | Spine (Phila Pa 1976) | 2000 | 11124729 | No |
| 642 | 6243 | 3121.5 | 188.8 | 94.4 | Microenvironmental regulation of tumor progression and metastasis. | Daniela F Quail, Johanna A Joyce | Nat Med | 2013 | 24202395 | No |
| 643 | 3117 | 3117.0 | 0.0 | 0.0 | Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. | P Mitchell | Nature | 1961 | 13771349 | Yes |
| 644 | 9345 | 3115.0 | 219.2 | 73.1 | TopHat: discovering splice junctions with RNA-Seq. | Cole Trapnell, Lior Pachter, Steven L Salzberg | Bioinformatics | 2009 | 19289445 | Yes |
| 645 | 9333 | 3111.0 | 389.9 | 130.0 | Fast and sensitive protein alignment using DIAMOND. | Benjamin Buchfink, Chao Xie, Daniel H Huson | Nat Methods | 2015 | 25402007 | Yes |
| 646 | 3110 | 3110.0 | 64.1 | 64.1 | Elastic properties of lipid bilayers: theory and possible experiments. | W Helfrich | Z Naturforsch C | 1973 | 4273690 | Yes |
| 647 | 3099 | 3099.0 | 75.0 | 75.0 | Salt and drought stress signal transduction in plants. | Jian-Kang Zhu | Annu Rev Plant Biol | 2002 | 12221975 | No |
| 648 | 3094 | 3094.0 | 98.7 | 98.7 | Receiver operating characteristic curve in diagnostic test assessment. | Jayawant N Mandrekar | J Thorac Oncol | 2010 | 20736804 | No |
| 649 | 3087 | 3087.0 | 0.0 | 0.0 | The genetical structure of populations. | S Wright | Ann Eugen | 1951 | 24540312 | Yes |
| 650 | 6160 | 3080.0 | 202.4 | 101.2 | Tissue engineering. | R Langer, J P Vacanti | Science | 1993 | 8493529 | No |
| 651 | 3071 | 3071.0 | 73.0 | 73.0 | Cadherin cell adhesion receptors as a morphogenetic regulator. | M Takeichi | Science | 1991 | 2006419 | No |
| 652 | 3071 | 3071.0 | 0.0 | 0.0 | A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. | S Hakomori | J Biochem | 1964 | 14135466 | Yes |
| 653 | 3069 | 3069.0 | 80.1 | 80.1 | Molecular basis of bacterial outer membrane permeability revisited. | Hiroshi Nikaido | Microbiol Mol Biol Rev | 2003 | 14665678 | No |
| 654 | 3068 | 3068.0 | 82.6 | 82.6 | Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. | S W Kessler | J Immunol | 1975 | 1102604 | Yes |
| 655 | 3068 | 3068.0 | 103.8 | 103.8 | An empirical correction for absorption anisotropy. | R H Blessing | Acta Crystallogr A | 1995 | 7702794 | Yes |
| 656 | 6132 | 3066.0 | 240.7 | 120.3 | Assessment of outcome after severe brain damage. | B Jennett, M Bond | Lancet | 1975 | 46957 | Yes |
| 657 | 3066 | 3066.0 | 89.4 | 89.4 | Physiology and neurobiology of stress and adaptation: central role of the brain. | Bruce S McEwen | Physiol Rev | 2007 | 17615391 | No |
| 658 | 6126 | 3063.0 | 240.7 | 120.3 | The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. | S H Downs, N Black | J Epidemiol Community Health | 1998 | 9764259 | Yes |
| 659 | 3060 | 3060.0 | 58.6 | 58.6 | RNA interference. | Gregory J Hannon | Nature | 2002 | 12110901 | No |
| 660 | 3053 | 3053.0 | 0.0 | 0.0 | Catheter replacement of the needle in percutaneous arteriography; a new technique. | S I Seldinger | Acta Radiol (Stockh) | 1953 | 13057644 | Yes |
| 661 | 3051 | 3051.0 | 64.0 | 64.0 | Toll-like receptors and innate immunity. | R Medzhitov | Nat Rev Immunol | 2001 | 11905821 | No |
| 662 | 3044 | 3044.0 | 62.6 | 62.6 | Papillomaviruses and cancer: from basic studies to clinical application. | Harald Zur Hausen | Nat Rev Cancer | 2002 | 12044010 | No |
| 663 | 6084 | 3042.0 | 200.8 | 100.4 | Computed tomography--an increasing source of radiation exposure. | David J Brenner, Eric J Hall | N Engl J Med | 2007 | 18046031 | No |
| 664 | 3040 | 3040.0 | 79.7 | 79.7 | Network pharmacology: the next paradigm in drug discovery. | Andrew L Hopkins | Nat Chem Biol | 2008 | 18936753 | No |
| 665 | 9114 | 3038.0 | 189.2 | 63.1 | Significance analysis of microarrays applied to the ionizing radiation response. | V G Tusher, R Tibshirani, G Chu | Proc Natl Acad Sci U S A | 2001 | 11309499 | Yes |
| 666 | 3035 | 3035.0 | 85.4 | 85.4 | The genetic legacy of the Quaternary ice ages. | G Hewitt | Nature | 2000 | 10879524 | No |
| 667 | 3034 | 3034.0 | 89.8 | 89.8 | The magical number 4 in short-term memory: a reconsideration of mental storage capacity. | N Cowan | Behav Brain Sci | 2001 | 11515286 | Yes |
| 668 | 3032 | 3032.0 | 73.9 | 73.9 | Structure and function of telomeres. | E H Blackburn | Nature | 1991 | 1708110 | No |
| 669 | 3029 | 3029.0 | 83.0 | 83.0 | Analysis of gene diversity in subdivided populations. | M Nei | Proc Natl Acad Sci U S A | 1973 | 4519626 | Yes |
| 670 | 6051 | 3025.5 | 0.0 | 0.0 | Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. | J Sedlak, R H Lindsay | Anal Biochem | 1968 | 4973948 | Yes |
| 671 | 6049 | 3024.5 | 162.7 | 81.3 | Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. | G Kresse, J Hafner | Phys Rev B Condens Matter | 1994 | 10010505 | Yes |
| 672 | 3023 | 3023.0 | 120.2 | 120.2 | Metazoan MicroRNAs. | David P Bartel | Cell | 2018 | 29570994 | No |
| 673 | 18094 | 3015.7 | 413.1 | 68.9 | Phaser crystallographic software. | Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read | J Appl Crystallogr | 2007 | 19461840 | Yes |
| 674 | 3015 | 3015.0 | 0.0 | 0.0 | A study of fixation for electron microscopy. | G E Palade | J Exp Med | 1952 | 14927794 | Yes |
| 675 | 9036 | 3012.0 | 214.6 | 71.5 | Pathogen recognition and innate immunity. | Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi | Cell | 2006 | 16497588 | No |
| 676 | 3010 | 3010.0 | 67.3 | 67.3 | Nuclear factor-kappaB in cancer development and progression. | Michael Karin | Nature | 2006 | 16724054 | No |
| 677 | 2999 | 2999.0 | 58.2 | 58.2 | Models for the specific adhesion of cells to cells. | G I Bell | Science | 1978 | 347575 | No |
| 678 | 5998 | 2999.0 | 137.8 | 68.9 | The fluid mosaic model of the structure of cell membranes. | S J Singer, G L Nicolson | Science | 1972 | 4333397 | Yes |
| 679 | 8972 | 2990.7 | 394.8 | 131.6 | Scoping studies: advancing the methodology. | Danielle Levac, Heather Colquhoun, Kelly K O'Brien | Implement Sci | 2010 | 20854677 | Yes |
| 680 | 2986 | 2986.0 | 114.5 | 114.5 | Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. | Konrad M Andrassy | Kidney Int | 2013 | 23989362 | Yes |
| 681 | 5971 | 2985.5 | 127.0 | 63.5 | Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. | D B Smith, K S Johnson | Gene | 1988 | 3047011 | Yes |
| 682 | 2984 | 2984.0 | 96.8 | 96.8 | Matrix metalloproteinases and their inhibitors in connective tissue remodeling. | J F Woessner | FASEB J | 1991 | 1850705 | No |
| 683 | 5968 | 2984.0 | 205.2 | 102.6 | The biofilm matrix. | Hans-Curt Flemming, Jost Wingender | Nat Rev Microbiol | 2010 | 20676145 | No |
| 684 | 2983 | 2983.0 | 90.7 | 90.7 | Gctf: Real-time CTF determination and correction. | Kai Zhang | J Struct Biol | 2016 | 26592709 | Yes |
| 685 | 2978 | 2978.0 | 45.2 | 45.2 | A gene complex controlling segmentation in Drosophila. | E B Lewis | Nature | 1978 | 103000 | Yes |
| 686 | 2975 | 2975.0 | 64.8 | 64.8 | Towards a network theory of the immune system. | N K Jerne | Ann Immunol (Paris) | 1974 | 4142565 | No |
| 687 | 2975 | 2975.0 | 0.0 | 0.0 | The gel-filtration behaviour of proteins related to their molecular weights over a wide range. | P Andrews | Biochem J | 1965 | 5862401 | Yes |
| 688 | 5950 | 2975.0 | 142.4 | 71.2 | Autophagy in the pathogenesis of disease. | Beth Levine, Guido Kroemer | Cell | 2008 | 18191218 | No |
| 689 | 2966 | 2966.0 | 59.4 | 59.4 | Interleukin-12 and the regulation of innate resistance and adaptive immunity. | Giorgio Trinchieri | Nat Rev Immunol | 2003 | 12563297 | No |
| 690 | 2965 | 2965.0 | 74.3 | 74.3 | P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation. | Berk Hess | J Chem Theory Comput | 2008 | 26619985 | Yes |
| 691 | 2962 | 2962.0 | 91.6 | 91.6 | Primate models of movement disorders of basal ganglia origin. | M R DeLong | Trends Neurosci | 1990 | 1695404 | No |
| 692 | 8880 | 2960.0 | 255.8 | 85.3 | Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. | Y Gavrieli, Y Sherman, S A Ben-Sasson | J Cell Biol | 1992 | 1400587 | Yes |
| 693 | 5918 | 2959.0 | 136.4 | 68.2 | Oncomirs - microRNAs with a role in cancer. | Aurora Esquela-Kerscher, Frank J Slack | Nat Rev Cancer | 2006 | 16557279 | No |
| 694 | 47298 | 2956.1 | 1507.1 | 94.2 | Fiji: an open-source platform for biological-image analysis. | Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona | Nat Methods | 2012 | 22743772 | Yes |
| 695 | 2956 | 2956.0 | 56.4 | 56.4 | Genome maintenance mechanisms for preventing cancer. | J H Hoeijmakers | Nature | 2001 | 11357144 | No |
| 696 | 2956 | 2956.0 | 192.2 | 192.2 | User's guide to correlation coefficients. | Haldun Akoglu | Turk J Emerg Med | 2018 | 30191186 | No |
| 697 | 5909 | 2954.5 | 174.8 | 87.4 | Adherence to medication. | Lars Osterberg, Terrence Blaschke | N Engl J Med | 2005 | 16079372 | No |
| 698 | 2952 | 2952.0 | 52.0 | 52.0 | Mechanisms underlying ubiquitination. | C M Pickart | Annu Rev Biochem | 2001 | 11395416 | No |
| 699 | 2950 | 2950.0 | 90.8 | 90.8 | Implications of normal brain development for the pathogenesis of schizophrenia. | D R Weinberger | Arch Gen Psychiatry | 1987 | 3606332 | Yes |
| 700 | 2950 | 2950.0 | 67.9 | 67.9 | Inflammatory bowel disease. | Daniel K Podolsky | N Engl J Med | 2002 | 12167685 | No |
| 701 | 2950 | 2950.0 | 74.0 | 74.0 | An index to quantify an individual's scientific research output. | J E Hirsch | Proc Natl Acad Sci U S A | 2005 | 16275915 | Yes |
| 702 | 2947 | 2947.0 | 62.3 | 62.3 | Principles of CDK regulation. | D O Morgan | Nature | 1995 | 7877684 | No |
| 703 | 8841 | 2947.0 | 274.4 | 91.5 | Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. | Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar | J Phys Chem B | 2009 | 19366259 | Yes |
| 704 | 8832 | 2944.0 | 257.2 | 85.7 | Quantum mechanical continuum solvation models. | Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi | Chem Rev | 2005 | 16092826 | Yes |
| 705 | 2942 | 2942.0 | 116.9 | 116.9 | UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. | D W Russell | J Pers Assess | 1996 | 8576833 | Yes |
| 706 | 2937 | 2937.0 | 79.8 | 79.8 | Intestinal mucosal barrier function in health and disease. | Jerrold R Turner | Nat Rev Immunol | 2009 | 19855405 | No |
| 707 | 2934 | 2934.0 | 68.2 | 68.2 | Bone resorption by osteoclasts. | S L Teitelbaum | Science | 2000 | 10968780 | No |
| 708 | 2933 | 2933.0 | 71.9 | 71.9 | Chemokines--chemotactic cytokines that mediate inflammation. | A D Luster | N Engl J Med | 1998 | 9459648 | No |
| 709 | 5863 | 2931.5 | 187.1 | 93.5 | Accurate and simple analytic representation of the electron-gas correlation energy. | J P Perdew, Y Wang | Phys Rev B Condens Matter | 1992 | 10001404 | Yes |
| 710 | 8777 | 2925.7 | 246.5 | 82.2 | trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. | Salvador Capella-Gutierrez, Jose M Silla-Martinez, Toni Gabaldon | Bioinformatics | 2009 | 19505945 | Yes |
| 711 | 2923 | 2923.0 | 93.7 | 93.7 | Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. | Peter C Austin | Pharm Stat | 2011 | 20925139 | Yes |
| 712 | 5845 | 2922.5 | 117.0 | 58.5 | Establishment in culture of pluripotential cells from mouse embryos. | M J Evans, M H Kaufman | Nature | 1981 | 7242681 | Yes |
| 713 | 2920 | 2920.0 | 131.0 | 131.0 | Qualitative research. Introducing focus groups. | J Kitzinger | BMJ | 1995 | 7633241 | Yes |
| 714 | 5837 | 2918.5 | 263.2 | 131.6 | Revised methods for the Salmonella mutagenicity test. | D M Maron, B N Ames | Mutat Res | 1983 | 6341825 | Yes |
| 715 | 2918 | 2918.0 | 156.9 | 156.9 | Determination and quantification of content validity. | M R Lynn | Nurs Res | 1986 | 3640358 | Yes |
| 716 | 8752 | 2917.3 | 0.0 | 0.0 | The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. | R J Havel, H A Eder, J H Bragdon | J Clin Invest | 1955 | 13252080 | Yes |
| 717 | 2917 | 2917.0 | 97.0 | 97.0 | A computational approach to edge detection. | J Canny | IEEE Trans Pattern Anal Mach Intell | 1986 | 21869365 | Yes |
| 718 | 5833 | 2916.5 | 155.4 | 77.7 | Reactive oxygen species: metabolism, oxidative stress, and signal transduction. | Klaus Apel, Heribert Hirt | Annu Rev Plant Biol | 2004 | 15377225 | No |
| 719 | 2913 | 2913.0 | 79.9 | 79.9 | Predictive reward signal of dopamine neurons. | W Schultz | J Neurophysiol | 1998 | 9658025 | No |
| 720 | 8737 | 2912.3 | 248.8 | 82.9 | Cortical surface-based analysis. I. Segmentation and surface reconstruction. | A M Dale, B Fischl, M I Sereno | Neuroimage | 1999 | 9931268 | Yes |
| 721 | 2912 | 2912.0 | 71.4 | 71.4 | Phase separation of integral membrane proteins in Triton X-114 solution. | C Bordier | J Biol Chem | 1981 | 6257680 | Yes |
| 722 | 5824 | 2912.0 | 0.0 | 0.0 | Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. | J D Watson, F H Crick | Nature | 1953 | 13054692 | Yes |
| 723 | 5823 | 2911.5 | 168.3 | 84.2 | Inositol trisphosphate, a novel second messenger in cellular signal transduction. | M J Berridge, R F Irvine | Nature | 1984 | 6095092 | No |
| 724 | 2911 | 2911.0 | 102.2 | 102.2 | Role of oxidative stress in development of complications in diabetes. | J W Baynes | Diabetes | 1991 | 2010041 | No |
| 725 | 5822 | 2911.0 | 203.5 | 101.8 | A method of comparing the areas under receiver operating characteristic curves derived from the same cases. | J A Hanley, B J McNeil | Radiology | 1983 | 6878708 | Yes |
| 726 | 2908 | 2908.0 | 134.4 | 134.4 | Detecting alcoholism. The CAGE questionnaire. | J A Ewing | JAMA | 1984 | 6471323 | Yes |
| 727 | 2902 | 2902.0 | 75.5 | 75.5 | A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. | Pascal Fries | Trends Cogn Sci | 2005 | 16150631 | No |
| 728 | 2901 | 2901.0 | 62.9 | 62.9 | Telomere measurement by quantitative PCR. | Richard M Cawthon | Nucleic Acids Res | 2002 | 12000852 | Yes |
| 729 | 2901 | 2901.0 | 112.1 | 112.1 | Missing data analysis: making it work in the real world. | John W Graham | Annu Rev Psychol | 2009 | 18652544 | No |
| 730 | 2899 | 2899.0 | 0.0 | 0.0 | Notes on sugar determination. | M Smogyi | J Biol Chem | 1952 | 14938350 | Yes |
| 731 | 5797 | 2898.5 | 139.0 | 69.5 | A scaling normalization method for differential expression analysis of RNA-seq data. | Mark D Robinson, Alicia Oshlack | Genome Biol | 2010 | 20196867 | Yes |
| 732 | 2898 | 2898.0 | 67.3 | 67.3 | Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. | G P Smith | Science | 1985 | 4001944 | Yes |
| 733 | 5791 | 2895.5 | 164.6 | 82.3 | Rapid isolation of high molecular weight plant DNA. | M G Murray, W F Thompson | Nucleic Acids Res | 1980 | 7433111 | Yes |
| 734 | 2892 | 2892.0 | 0.0 | 0.0 | A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. | E A Gehan | Biometrika | 1965 | 14341275 | Yes |
| 735 | 5778 | 2889.0 | 190.1 | 95.0 | PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. | Daniel R Roe, Thomas E Cheatham | J Chem Theory Comput | 2013 | 26583988 | Yes |
| 736 | 2886 | 2886.0 | 0.0 | 0.0 | Separation of leukocytes from blood and bone marrow. Introduction. | A Boyum | Scand J Clin Lab Invest Suppl | 1968 | 5707208 | Yes |
| 737 | 11530 | 2882.5 | 299.9 | 75.0 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. | C A Lipinski, F Lombardo, B W Dominy, P J Feeney | Adv Drug Deliv Rev | 2001 | 11259830 | No |
| 738 | 2879 | 2879.0 | 51.4 | 51.4 | One-step gene disruption in yeast. | R J Rothstein | Methods Enzymol | 1983 | 6310324 | Yes |
| 739 | 2867 | 2867.0 | 78.5 | 78.5 | Inferring the historical patterns of biological evolution. | M Pagel | Nature | 1999 | 10553904 | Yes |
| 740 | 8596 | 2865.3 | 228.2 | 76.1 | Immunity, inflammation, and cancer. | Sergei I Grivennikov, Florian R Greten, Michael Karin | Cell | 2010 | 20303878 | No |
| 741 | 5722 | 2861.0 | 197.8 | 98.9 | Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). | Kathryn M Connor, Jonathan R T Davidson | Depress Anxiety | 2003 | 12964174 | Yes |
| 742 | 2861 | 2861.0 | 0.0 | 0.0 | Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. | W C Schneider | J Biol Chem | 1945 | 21005736 | Yes |
| 743 | 5716 | 2858.0 | 151.3 | 75.7 | ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. | B Ravel, M Newville | J Synchrotron Radiat | 2005 | 15968136 | Yes |
| 744 | 2857 | 2857.0 | 72.5 | 72.5 | Memory--a century of consolidation. | J L McGaugh | Science | 2000 | 10634773 | No |
| 745 | 8557 | 2852.3 | 240.8 | 80.3 | Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. | G Fairbanks, T L Steck, D F Wallach | Biochemistry | 1971 | 4326772 | Yes |
| 746 | 2852 | 2852.0 | 77.7 | 77.7 | A theory of cortical responses. | Karl Friston | Philos Trans R Soc Lond B Biol Sci | 2005 | 15937014 | No |
| 747 | 5703 | 2851.5 | 213.0 | 106.5 | Longitudinal data analysis for discrete and continuous outcomes. | S L Zeger, K Y Liang | Biometrics | 1986 | 3719049 | Yes |
| 748 | 5702 | 2851.0 | 119.0 | 59.5 | Innate immune recognition. | Charles A Janeway, Ruslan Medzhitov | Annu Rev Immunol | 2002 | 11861602 | No |
| 749 | 2851 | 2851.0 | 67.5 | 67.5 | Vascular endothelial growth factor: basic science and clinical progress. | Napoleone Ferrara | Endocr Rev | 2004 | 15294883 | No |
| 750 | 5698 | 2849.0 | 0.0 | 0.0 | Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. | J Silness, H Loe | Acta Odontol Scand | 1964 | 14158464 | Yes |
| 751 | 2844 | 2844.0 | 84.7 | 84.7 | A simple technique for demonstrating centromeric heterochromatin. | A T Sumner | Exp Cell Res | 1972 | 4117921 | Yes |
| 752 | 2844 | 2844.0 | 71.0 | 71.0 | MYC on the path to cancer. | Chi V Dang | Cell | 2012 | 22464321 | No |
| 753 | 2844 | 2844.0 | 117.8 | 117.8 | Deep learning in neural networks: an overview. | Jurgen Schmidhuber | Neural Netw | 2015 | 25462637 | No |
| 754 | 2836 | 2836.0 | 0.0 | 0.0 | Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. | B E Murphy | J Clin Endocrinol Metab | 1967 | 4291524 | Yes |
| 755 | 2836 | 2836.0 | 69.0 | 69.0 | Prostaglandins and leukotrienes: advances in eicosanoid biology. | C D Funk | Science | 2001 | 11729303 | No |
| 756 | 2834 | 2834.0 | 0.0 | 0.0 | Satellite cell of skeletal muscle fibers. | A Mauro | J Biophys Biochem Cytol | 1961 | 13768451 | Yes |
| 757 | 2834 | 2834.0 | 0.0 | 0.0 | A study of the adrenotropic receptors. | R P Ahlquist | Am J Physiol | 1948 | 18882199 | Yes |
| 758 | 5663 | 2831.5 | 139.5 | 69.8 | Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. | F W Studier, B A Moffatt | J Mol Biol | 1986 | 3537305 | Yes |
| 759 | 5661 | 2830.5 | 0.0 | 0.0 | Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. | J Glowinski, L L Iversen | J Neurochem | 1966 | 5950056 | Yes |
| 760 | 5659 | 2829.5 | 156.9 | 78.5 | UniFrac: a new phylogenetic method for comparing microbial communities. | Catherine Lozupone, Rob Knight | Appl Environ Microbiol | 2005 | 16332807 | Yes |
| 761 | 2829 | 2829.0 | 79.1 | 79.1 | Hypoxia-inducible factors in physiology and medicine. | Gregg L Semenza | Cell | 2012 | 22304911 | No |
| 762 | 2828 | 2828.0 | 68.4 | 68.4 | Molecular chaperones in cellular protein folding. | F U Hartl | Nature | 1996 | 8637592 | No |
| 763 | 5654 | 2827.0 | 140.6 | 70.3 | Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. | D Hanahan, J Folkman | Cell | 1996 | 8756718 | No |
| 764 | 5650 | 2825.0 | 154.7 | 77.3 | Alzheimer's disease: the amyloid cascade hypothesis. | J A Hardy, G A Higgins | Science | 1992 | 1566067 | No |
| 765 | 5638 | 2819.0 | 188.5 | 94.2 | Deciphering key features in protein structures with the new ENDscript server. | Xavier Robert, Patrice Gouet | Nucleic Acids Res | 2014 | 24753421 | Yes |
| 766 | 2818 | 2818.0 | 59.0 | 59.0 | On the number of segregating sites in genetical models without recombination. | G A Watterson | Theor Popul Biol | 1975 | 1145509 | Yes |
| 767 | 5634 | 2817.0 | 0.0 | 0.0 | A modified uronic acid carbazole reaction. | T Bitter, H M Muir | Anal Biochem | 1962 | 13971270 | Yes |
| 768 | 2816 | 2816.0 | 121.4 | 121.4 | The brain's default mode network. | Marcus E Raichle | Annu Rev Neurosci | 2015 | 25938726 | No |
| 769 | 2815 | 2815.0 | 54.7 | 54.7 | Mechanisms of type-I- and type-II-interferon-mediated signalling. | Leonidas C Platanias | Nat Rev Immunol | 2005 | 15864272 | No |
| 770 | 2814 | 2814.0 | 84.3 | 84.3 | Two-sided confidence intervals for the single proportion: comparison of seven methods. | R G Newcombe | Stat Med | 1998 | 9595616 | Yes |
| 771 | 8438 | 2812.7 | 215.1 | 71.7 | RNA-Seq: a revolutionary tool for transcriptomics. | Zhong Wang, Mark Gerstein, Michael Snyder | Nat Rev Genet | 2009 | 19015660 | No |
| 772 | 2812 | 2812.0 | 83.0 | 83.0 | Infrared spectroscopy of proteins. | Andreas Barth | Biochim Biophys Acta | 2007 | 17692815 | No |
| 773 | 5622 | 2811.0 | 0.0 | 0.0 | The Social Readjustment Rating Scale. | T H Holmes, R H Rahe | J Psychosom Res | 1967 | 6059863 | Yes |
| 774 | 11242 | 2810.5 | 385.8 | 96.5 | Establishing a standard definition for child overweight and obesity worldwide: international survey. | T J Cole, M C Bellizzi, K M Flegal, W H Dietz | BMJ | 2000 | 10797032 | Yes |
| 775 | 5616 | 2808.0 | 206.6 | 103.3 | A feature-integration theory of attention. | A M Treisman, G Gelade | Cogn Psychol | 1980 | 7351125 | Yes |
| 776 | 5612 | 2806.0 | 153.4 | 76.7 | The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. | J Vieira, J Messing | Gene | 1982 | 6295879 | Yes |
| 777 | 5605 | 2802.5 | 134.1 | 67.0 | Caspases: enemies within. | N A Thornberry, Y Lazebnik | Science | 1998 | 9721091 | No |
| 778 | 2802 | 2802.0 | 56.8 | 56.8 | The danger model: a renewed sense of self. | Polly Matzinger | Science | 2002 | 11951032 | Yes |
| 779 | 11207 | 2801.8 | 345.8 | 86.5 | Cancer statistics, 2010. | Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth Ward | CA Cancer J Clin | 2010 | 20610543 | Yes |
| 780 | 2799 | 2799.0 | 69.3 | 69.3 | Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. | S A Bustin | J Mol Endocrinol | 2000 | 11013345 | No |
| 781 | 2798 | 2798.0 | 144.9 | 144.9 | The Global Epidemic of the Metabolic Syndrome. | Mohammad G Saklayen | Curr Hypertens Rep | 2018 | 29480368 | No |
| 782 | 5591 | 2795.5 | 173.2 | 86.6 | Glutathione. | A Meister, M E Anderson | Annu Rev Biochem | 1983 | 6137189 | No |
| 783 | 2795 | 2795.0 | 64.6 | 64.6 | Cell adhesion: the molecular basis of tissue architecture and morphogenesis. | B M Gumbiner | Cell | 1996 | 8608588 | No |
| 784 | 8383 | 2794.3 | 354.8 | 118.3 | The behaviour change wheel: a new method for characterising and designing behaviour change interventions. | Susan Michie, Maartje M Van Stralen, Robert West | Implement Sci | 2011 | 21513547 | No |
| 785 | 5580 | 2790.0 | 0.0 | 0.0 | A method for determining the sedimentation behavior of enzymes: application to protein mixtures. | R G Martin, B N Ames | J Biol Chem | 1961 | 13767412 | Yes |
| 786 | 11142 | 2785.5 | 291.7 | 72.9 | Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. | P W Rigby, M Dieckmann, C Rhodes, P Berg | J Mol Biol | 1977 | 881736 | Yes |
| 787 | 2784 | 2784.0 | 61.1 | 61.1 | The distribution of secondary growths in cancer of the breast. 1889. | S Paget | Cancer Metastasis Rev | 1989 | 2673568 | No |
| 788 | 5560 | 2780.0 | 130.0 | 65.0 | Myeloid-derived suppressor cells as regulators of the immune system. | Dmitry I Gabrilovich, Srinivas Nagaraj | Nat Rev Immunol | 2009 | 19197294 | No |
| 789 | 5555 | 2777.5 | 151.2 | 75.6 | A global optimisation method for robust affine registration of brain images. | M Jenkinson, S Smith | Med Image Anal | 2001 | 11516708 | Yes |
| 790 | 2777 | 2777.0 | 85.4 | 85.4 | Stereotaxic mapping of the monoamine pathways in the rat brain. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4109331 | Yes |
| 791 | 2777 | 2777.0 | 0.0 | 0.0 | Efficient trace-labelling of proteins with iodine. | A S McFARLANE | Nature | 1958 | 13566175 | Yes |
| 792 | 5547 | 2773.5 | 118.5 | 59.2 | MicroRNAs: small RNAs with a big role in gene regulation. | Lin He, Gregory J Hannon | Nat Rev Genet | 2004 | 15211354 | No |
| 793 | 2770 | 2770.0 | 79.4 | 79.4 | Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. | P Correa | Cancer Res | 1992 | 1458460 | No |
| 794 | 2766 | 2766.0 | 61.5 | 61.5 | Epigenetics in cancer. | Manel Esteller | N Engl J Med | 2008 | 18337604 | No |
| 795 | 2765 | 2765.0 | 68.7 | 68.7 | Cell death during development of the nervous system. | R W Oppenheim | Annu Rev Neurosci | 1991 | 2031577 | No |
| 796 | 5529 | 2764.5 | 188.9 | 94.5 | SPSS and SAS procedures for estimating indirect effects in simple mediation models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods Instrum Comput | 2004 | 15641418 | Yes |
| 797 | 5527 | 2763.5 | 112.3 | 56.1 | Untangling the ErbB signalling network. | Y Yarden, M X Sliwkowski | Nat Rev Mol Cell Biol | 2001 | 11252954 | No |
| 798 | 2763 | 2763.0 | 86.0 | 86.0 | Social determinants of health inequalities. | Michael Marmot | Lancet | 2005 | 15781105 | Yes |
| 799 | 2763 | 2763.0 | 61.5 | 61.5 | Rab GTPases as coordinators of vesicle traffic. | Harald Stenmark | Nat Rev Mol Cell Biol | 2009 | 19603039 | No |
| 800 | 5524 | 2762.0 | 259.9 | 129.9 | Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. | N S Jacobson, P Truax | J Consult Clin Psychol | 1991 | 2002127 | Yes |
| 801 | 5520 | 2760.0 | 167.1 | 83.5 | Judgment under Uncertainty: Heuristics and Biases. | A Tversky, D Kahneman | Science | 1974 | 17835457 | Yes |
| 802 | 2757 | 2757.0 | 0.0 | 0.0 | Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. | L Svennerholm | Biochim Biophys Acta | 1957 | 13436486 | Yes |
| 803 | 2755 | 2755.0 | 60.1 | 60.1 | Evolving concepts of rheumatoid arthritis. | Gary S Firestein | Nature | 2003 | 12748655 | No |
| 804 | 2747 | 2747.0 | 109.2 | 109.2 | Neutrophil extracellular traps in immunity and disease. | Venizelos Papayannopoulos | Nat Rev Immunol | 2018 | 28990587 | No |
| 805 | 2746 | 2746.0 | 65.1 | 65.1 | The inflammatory reflex. | Kevin J Tracey | Nature | 2002 | 12490958 | No |
| 806 | 5489 | 2744.5 | 112.3 | 56.1 | High-efficiency transformation of mammalian cells by plasmid DNA. | C Chen, H Okayama | Mol Cell Biol | 1987 | 3670292 | Yes |
| 807 | 10960 | 2740.0 | 253.7 | 63.4 | MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. | Kazutaka Katoh, Kazuharu Misawa, Kei-Ichi Kuma, Takashi Miyata | Nucleic Acids Res | 2002 | 12136088 | Yes |
| 808 | 2732 | 2732.0 | 54.3 | 54.3 | Tumour-educated macrophages promote tumour progression and metastasis. | Jeffrey W Pollard | Nat Rev Cancer | 2004 | 14708027 | No |
| 809 | 2731 | 2731.0 | 87.7 | 87.7 | PsychoPy--Psychophysics software in Python. | Jonathan W Peirce | J Neurosci Methods | 2007 | 17254636 | Yes |
| 810 | 5458 | 2729.0 | 189.4 | 94.7 | The neural basis of drug craving: an incentive-sensitization theory of addiction. | T E Robinson, K C Berridge | Brain Res Brain Res Rev | 1993 | 8401595 | No |
| 811 | 2728 | 2728.0 | 69.1 | 69.1 | Immunological and inflammatory functions of the interleukin-1 family. | Charles A Dinarello | Annu Rev Immunol | 2009 | 19302047 | No |
| 812 | 5452 | 2726.0 | 294.4 | 147.2 | OrthoFinder: phylogenetic orthology inference for comparative genomics. | David M Emms, Steven Kelly | Genome Biol | 2019 | 31727128 | Yes |
| 813 | 2722 | 2722.0 | 96.5 | 96.5 | Working memory. | A Baddeley | Science | 1992 | 1736359 | No |
| 814 | 2721 | 2721.0 | 90.6 | 90.6 | What are the functional consequences of neurocognitive deficits in schizophrenia? | M F Green | Am J Psychiatry | 1996 | 8610818 | No |
| 815 | 8154 | 2718.0 | 174.2 | 58.1 | Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. | C M Gorman, L F Moffat, B H Howard | Mol Cell Biol | 1982 | 6960240 | Yes |
| 816 | 2717 | 2717.0 | 147.6 | 147.6 | Making sense of implementation theories, models and frameworks. | Per Nilsen | Implement Sci | 2015 | 25895742 | Yes |
| 817 | 2715 | 2715.0 | 80.2 | 80.2 | Formation and Structure of Self-Assembled Monolayers. | Abraham Ulman | Chem Rev | 1996 | 11848802 | Yes |
| 818 | 10854 | 2713.5 | 291.2 | 72.8 | GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. | Berk Hess, Carsten Kutzner, David Van Der Spoel, Erik Lindahl | J Chem Theory Comput | 2008 | 26620784 | Yes |
| 819 | 10848 | 2712.0 | 239.9 | 60.0 | Cluster analysis and display of genome-wide expression patterns. | M B Eisen, P T Spellman, P O Brown, D Botstein | Proc Natl Acad Sci U S A | 1998 | 9843981 | Yes |
| 820 | 5421 | 2710.5 | 96.7 | 48.4 | A general method applicable to the search for similarities in the amino acid sequence of two proteins. | S B Needleman, C D Wunsch | J Mol Biol | 1970 | 5420325 | Yes |
| 821 | 5417 | 2708.5 | 139.8 | 69.9 | The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. | Karen Bedard, Karl-Heinz Krause | Physiol Rev | 2007 | 17237347 | No |
| 822 | 2706 | 2706.0 | 73.3 | 73.3 | Dominant forces in protein folding. | K A Dill | Biochemistry | 1990 | 2207096 | No |
| 823 | 2701 | 2701.0 | 0.0 | 0.0 | Evaluating the quality of medical care. | A Donabedian | Milbank Mem Fund Q | 1966 | 5338568 | No |
| 824 | 5401 | 2700.5 | 146.7 | 73.3 | Autophagy: renovation of cells and tissues. | Noboru Mizushima, Masaaki Komatsu | Cell | 2011 | 22078875 | No |
| 825 | 2699 | 2699.0 | 67.5 | 67.5 | Cancer nanotechnology: opportunities and challenges. | Mauro Ferrari | Nat Rev Cancer | 2005 | 15738981 | No |
| 826 | 2698 | 2698.0 | 70.2 | 70.2 | Using circular dichroism spectra to estimate protein secondary structure. | Norma J Greenfield | Nat Protoc | 2006 | 17406547 | Yes |
| 827 | 2698 | 2698.0 | 147.4 | 147.4 | Understanding Bland Altman analysis. | Davide Giavarina | Biochem Med (Zagreb) | 2015 | 26110027 | No |
| 828 | 2690 | 2690.0 | 60.4 | 60.4 | Angiogenesis in life, disease and medicine. | Peter Carmeliet | Nature | 2005 | 16355210 | No |
| 829 | 2689 | 2689.0 | 129.6 | 129.6 | Structural Model Evaluation and Modification: An Interval Estimation Approach. | J H Steiger | Multivariate Behav Res | 1990 | 26794479 | Yes |
| 830 | 13435 | 2687.0 | 329.9 | 66.0 | Development and testing of a general amber force field. | Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case | J Comput Chem | 2004 | 15116359 | Yes |
| 831 | 2683 | 2683.0 | 96.0 | 96.0 | Perceived exertion as an indicator of somatic stress. | G Borg | Scand J Rehabil Med | 1970 | 5523831 | Yes |
| 832 | 8047 | 2682.3 | 218.4 | 72.8 | MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. | Sudhir Kumar, Koichiro Tamura, Masatoshi Nei | Brief Bioinform | 2004 | 15260895 | Yes |
| 833 | 10683 | 2670.8 | 415.3 | 103.8 | Common method biases in behavioral research: a critical review of the literature and recommended remedies. | Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P Podsakoff | J Appl Psychol | 2003 | 14516251 | No |
| 834 | 2670 | 2670.0 | 68.7 | 68.7 | The nerve growth factor 35 years later. | R Levi-Montalcini | Science | 1987 | 3306916 | No |
| 835 | 2662 | 2662.0 | 98.7 | 98.7 | Plant products as antimicrobial agents. | M M Cowan | Clin Microbiol Rev | 1999 | 10515903 | No |
| 836 | 2661 | 2661.0 | 73.3 | 73.3 | TGFβ signalling in context. | Joan Massague | Nat Rev Mol Cell Biol | 2012 | 22992590 | No |
| 837 | 2660 | 2660.0 | 78.2 | 78.2 | Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. | P Cuatrecasas | J Biol Chem | 1970 | 5432796 | Yes |
| 838 | 7977 | 2659.0 | 251.6 | 83.9 | Bacterial biofilms: a common cause of persistent infections. | J W Costerton, P S Stewart, E P Greenberg | Science | 1999 | 10334980 | No |
| 839 | 5313 | 2656.5 | 191.6 | 95.8 | Cancer immunotherapy using checkpoint blockade. | Antoni Ribas, Jedd D Wolchok | Science | 2018 | 29567705 | No |
| 840 | 5308 | 2654.0 | 115.1 | 57.5 | Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. | L A Greene, A S Tischler | Proc Natl Acad Sci U S A | 1976 | 1065897 | Yes |
| 841 | 5308 | 2654.0 | 121.3 | 60.6 | Signal integration in the endoplasmic reticulum unfolded protein response. | David Ron, Peter Walter | Nat Rev Mol Cell Biol | 2007 | 17565364 | No |
| 842 | 2652 | 2652.0 | 81.9 | 81.9 | The biology of oxygen radicals. | I Fridovich | Science | 1978 | 210504 | Yes |
| 843 | 5288 | 2644.0 | 185.7 | 92.8 | Shifting the genomic gold standard for the prokaryotic species definition. | Michael Richter, Ramon Rossello-Mora | Proc Natl Acad Sci U S A | 2009 | 19855009 | Yes |
| 844 | 5271 | 2635.5 | 108.3 | 54.1 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. | D Bonnet, J E Dick | Nat Med | 1997 | 9212098 | Yes |
| 845 | 2634 | 2634.0 | 111.3 | 111.3 | The validity and practicality of sun-reactive skin types I through VI. | T B Fitzpatrick | Arch Dermatol | 1988 | 3377516 | Yes |
| 846 | 5268 | 2634.0 | 158.7 | 79.3 | The number of people with glaucoma worldwide in 2010 and 2020. | H A Quigley, A T Broman | Br J Ophthalmol | 2006 | 16488940 | Yes |
| 847 | 5266 | 2633.0 | 147.6 | 73.8 | Oncology meets immunology: the cancer-immunity cycle. | Daniel S Chen, Ira Mellman | Immunity | 2013 | 23890059 | No |
| 848 | 2631 | 2631.0 | 0.0 | 0.0 | The catecholamine hypothesis of affective disorders: a review of supporting evidence. | J J Schildkraut | Am J Psychiatry | 1965 | 5319766 | No |
| 849 | 5262 | 2631.0 | 172.3 | 86.2 | The L-arginine-nitric oxide pathway. | S Moncada, A Higgs | N Engl J Med | 1993 | 7504210 | No |
| 850 | 2630 | 2630.0 | 0.0 | 0.0 | The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. | M L Anson | J Gen Physiol | 1938 | 19873094 | Yes |
| 851 | 2629 | 2629.0 | 100.5 | 100.5 | Qualitative research: standards, challenges, and guidelines. | K Malterud | Lancet | 2001 | 11513933 | Yes |
| 852 | 2625 | 2625.0 | 79.7 | 79.7 | A two process model of sleep regulation. | A A Borbely | Hum Neurobiol | 1982 | 7185792 | Yes |
| 853 | 20985 | 2623.1 | 843.8 | 105.5 | The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. | Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jorg Peplies, Frank Oliver Glockner | Nucleic Acids Res | 2013 | 23193283 | Yes |
| 854 | 2622 | 2622.0 | 88.2 | 88.2 | Simplified calculation of body-surface area. | R D Mosteller | N Engl J Med | 1987 | 3657876 | Yes |
| 855 | 5243 | 2621.5 | 118.7 | 59.4 | Signal transduction by receptors with tyrosine kinase activity. | A Ullrich, J Schlessinger | Cell | 1990 | 2158859 | No |
| 856 | 5242 | 2621.0 | 0.0 | 0.0 | Some quantitative uses of drug antagonists. | O Arunlakshana, H O Schild | Br J Pharmacol Chemother | 1959 | 13651579 | Yes |
| 857 | 2621 | 2621.0 | 79.8 | 79.8 | Epidemiology of viral hepatitis and hepatocellular carcinoma. | Hashem B El-Serag | Gastroenterology | 2012 | 22537432 | No |
| 858 | 5230 | 2615.0 | 0.0 | 0.0 | Periodontal Disease In Pregnancy. I. Prevalence And Severity. | H Loe, J Silness | Acta Odontol Scand | 1963 | 14121956 | Yes |
| 859 | 2615 | 2615.0 | 51.7 | 51.7 | Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. | Shimon Sakaguchi | Annu Rev Immunol | 2004 | 15032588 | No |
| 860 | 5224 | 2612.0 | 167.6 | 83.8 | A simple, rapid, and sensitive DNA assay procedure. | C Labarca, K Paigen | Anal Biochem | 1980 | 6158890 | Yes |
| 861 | 2609 | 2609.0 | 75.3 | 75.3 | Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. | R D Pascual-Marqui | Methods Find Exp Clin Pharmacol | 2002 | 12575463 | No |
| 862 | 2606 | 2606.0 | 79.3 | 79.3 | Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. | Leonardo Pantoni | Lancet Neurol | 2010 | 20610345 | No |
| 863 | 2605 | 2605.0 | 96.2 | 96.2 | Spinal and supraspinal factors in human muscle fatigue. | S C Gandevia | Physiol Rev | 2001 | 11581501 | No |
| 864 | 5205 | 2602.5 | 168.6 | 84.3 | The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. | H P Misra, I Fridovich | J Biol Chem | 1972 | 4623845 | Yes |
| 865 | 5201 | 2600.5 | 182.4 | 91.2 | Missing data: our view of the state of the art. | Joseph L Schafer, John W Graham | Psychol Methods | 2002 | 12090408 | Yes |
| 866 | 5195 | 2597.5 | 245.9 | 123.0 | Making sense of Cronbach's alpha. | Mohsen Tavakol, Reg Dennick | Int J Med Educ | 2011 | 28029643 | No |
| 867 | 2597 | 2597.0 | 56.6 | 56.6 | G1 phase progression: cycling on cue. | C J Sherr | Cell | 1994 | 7954821 | No |
| 868 | 5193 | 2596.5 | 148.4 | 74.2 | Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. | Michael D Fox, Marcus E Raichle | Nat Rev Neurosci | 2007 | 17704812 | No |
| 869 | 2596 | 2596.0 | 82.8 | 82.8 | Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. | B Samuelsson | Science | 1983 | 6301011 | Yes |
| 870 | 2594 | 2594.0 | 0.0 | 0.0 | Isolation by Distance. | S Wright | Genetics | 1943 | 17247074 | Yes |
| 871 | 2593 | 2593.0 | 84.3 | 84.3 | Hazards of heavy metal contamination. | Lars Jarup | Br Med Bull | 2003 | 14757716 | No |
| 872 | 5179 | 2589.5 | 165.6 | 82.8 | Neural mechanisms of selective visual attention. | R Desimone, J Duncan | Annu Rev Neurosci | 1995 | 7605061 | No |
| 873 | 2588 | 2588.0 | 74.0 | 74.0 | Delayed neuronal death in the gerbil hippocampus following ischemia. | T Kirino | Brain Res | 1982 | 7093691 | Yes |
| 874 | 2587 | 2587.0 | 67.7 | 67.7 | The physiology of glucagon-like peptide 1. | Jens Juul Holst | Physiol Rev | 2007 | 17928588 | No |
| 875 | 5168 | 2584.0 | 148.8 | 74.4 | Application of phylogenetic networks in evolutionary studies. | Daniel H Huson, David Bryant | Mol Biol Evol | 2006 | 16221896 | Yes |
| 876 | 2581 | 2581.0 | 67.9 | 67.9 | The blood-brain barrier in health and chronic neurodegenerative disorders. | Berislav V Zlokovic | Neuron | 2008 | 18215617 | No |
| 877 | 10292 | 2573.0 | 216.0 | 54.0 | WebLogo: a sequence logo generator. | Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner | Genome Res | 2004 | 15173120 | Yes |
| 878 | 5146 | 2573.0 | 153.3 | 76.7 | Software survey: VOSviewer, a computer program for bibliometric mapping. | Nees Jan Van Eck, Ludo Waltman | Scientometrics | 2010 | 20585380 | Yes |
| 879 | 2571 | 2571.0 | 0.0 | 0.0 | The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. | R R Porter | Biochem J | 1959 | 14434282 | Yes |
| 880 | 2570 | 2570.0 | 91.9 | 91.9 | The membrane actions of anesthetics and tranquilizers. | P Seeman | Pharmacol Rev | 1972 | 4565956 | No |
| 881 | 5131 | 2565.5 | 213.5 | 106.8 | A diagnostic interview: the schedule for affective disorders and schizophrenia. | J Endicott, R L Spitzer | Arch Gen Psychiatry | 1978 | 678037 | Yes |
| 882 | 5126 | 2563.0 | 209.2 | 104.6 | Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. | J V Durnin, J Womersley | Br J Nutr | 1974 | 4843734 | Yes |
| 883 | 2562 | 2562.0 | 0.0 | 0.0 | The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. | S Boyden | J Exp Med | 1962 | 13872176 | Yes |
| 884 | 2561 | 2561.0 | 94.9 | 94.9 | Eye movements in reading and information processing: 20 years of research. | K Rayner | Psychol Bull | 1998 | 9849112 | No |
| 885 | 2560 | 2560.0 | 51.8 | 51.8 | Universal control mechanism regulating onset of M-phase. | P Nurse | Nature | 1990 | 2138713 | No |
| 886 | 2560 | 2560.0 | 0.0 | 0.0 | The information capacity of the human motor system in controlling the amplitude of movement. | P M Fitts | J Exp Psychol | 1954 | 13174710 | Yes |
| 887 | 2560 | 2560.0 | 55.5 | 55.5 | Cisplatin: mode of cytotoxic action and molecular basis of resistance. | Zahid H Siddik | Oncogene | 2003 | 14576837 | No |
| 888 | 7675 | 2558.3 | 286.8 | 95.6 | Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. | Jack Bowden, George Davey Smith, Stephen Burgess | Int J Epidemiol | 2015 | 26050253 | Yes |
| 889 | 2558 | 2558.0 | 68.6 | 68.6 | Animal mitochondrial genomes. | J L Boore | Nucleic Acids Res | 1999 | 10101183 | No |
| 890 | 5114 | 2557.0 | 176.2 | 88.1 | Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. | James J Gross, Oliver P John | J Pers Soc Psychol | 2003 | 12916575 | Yes |
| 891 | 2557 | 2557.0 | 116.2 | 116.2 | International classification of sleep disorders-third edition: highlights and modifications. | Michael J Sateia | Chest | 2014 | 25367475 | No |
| 892 | 2554 | 2554.0 | 0.0 | 0.0 | Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. | O Smithies | Biochem J | 1955 | 13276348 | Yes |
| 893 | 2554 | 2554.0 | 73.7 | 73.7 | Working memory: looking back and looking forward. | Alan Baddeley | Nat Rev Neurosci | 2003 | 14523382 | No |
| 894 | 5105 | 2552.5 | 126.5 | 63.2 | Calculation of protein extinction coefficients from amino acid sequence data. | S C Gill, P H Von Hippel | Anal Biochem | 1989 | 2610349 | Yes |
| 895 | 5100 | 2550.0 | 189.5 | 94.8 | mTOR Signaling in Growth, Metabolism, and Disease. | Robert A Saxton, David M Sabatini | Cell | 2017 | 28283069 | No |
| 896 | 10196 | 2549.0 | 493.5 | 123.4 | The Satisfaction With Life Scale. | E Diener, R A Emmons, R J Larsen, S Griffin | J Pers Assess | 1985 | 16367493 | Yes |
| 897 | 2548 | 2548.0 | 47.2 | 47.2 | Targeting RAS signalling pathways in cancer therapy. | Julian Downward | Nat Rev Cancer | 2003 | 12509763 | No |
| 898 | 2545 | 2545.0 | 69.2 | 69.2 | Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. | Claudiu T Supuran | Nat Rev Drug Discov | 2008 | 18167490 | No |
| 899 | 5088 | 2544.0 | 139.0 | 69.5 | Nonparametric permutation tests for functional neuroimaging: a primer with examples. | Thomas E Nichols, Andrew P Holmes | Hum Brain Mapp | 2002 | 11747097 | Yes |
| 900 | 2544 | 2544.0 | 64.3 | 64.3 | The extracellular matrix: not just pretty fibrils. | Richard O Hynes | Science | 2009 | 19965464 | No |
| 901 | 5085 | 2542.5 | 148.6 | 74.3 | Macrophage plasticity and polarization: in vivo veritas. | Antonio Sica, Alberto Mantovani | J Clin Invest | 2012 | 22378047 | No |
| 902 | 5078 | 2539.0 | 165.7 | 82.8 | Random-effects models for longitudinal data. | N M Laird, J H Ware | Biometrics | 1982 | 7168798 | Yes |
| 903 | 2538 | 2538.0 | 61.4 | 61.4 | Causes and consequences of microRNA dysregulation in cancer. | Carlo M Croce | Nat Rev Genet | 2009 | 19763153 | No |
| 904 | 10135 | 2533.8 | 238.6 | 59.6 | Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. | A Krogh, B Larsson, G Von Heijne, E L Sonnhammer | J Mol Biol | 2001 | 11152613 | Yes |
| 905 | 5067 | 2533.5 | 102.5 | 51.2 | CDK inhibitors: positive and negative regulators of G1-phase progression. | C J Sherr, J M Roberts | Genes Dev | 1999 | 10385618 | No |
| 906 | 2533 | 2533.0 | 109.0 | 109.0 | Effective physician-patient communication and health outcomes: a review. | M A Stewart | CMAJ | 1995 | 7728691 | Yes |
| 907 | 5063 | 2531.5 | 118.1 | 59.0 | Brown adipose tissue: function and physiological significance. | Barbara Cannon, Jan Nedergaard | Physiol Rev | 2004 | 14715917 | No |
| 908 | 7579 | 2526.3 | 269.0 | 89.7 | Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. | R L Spitzer, K Kroenke, J B Williams | JAMA | 1999 | 10568646 | Yes |
| 909 | 2526 | 2526.0 | 58.8 | 58.8 | Nitric oxide and the immune response. | C Bogdan | Nat Immunol | 2001 | 11577346 | No |
| 910 | 2525 | 2525.0 | 0.0 | 0.0 | Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. | T Higuchi | J Pharm Sci | 1963 | 14088963 | Yes |
| 911 | 2524 | 2524.0 | 66.3 | 66.3 | Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. | Jane Glazebrook | Annu Rev Phytopathol | 2005 | 16078883 | No |
| 912 | 2523 | 2523.0 | 77.6 | 77.6 | Biofilms: microbial life on surfaces. | Rodney M Donlan | Emerg Infect Dis | 2002 | 12194761 | No |
| 913 | 2523 | 2523.0 | 0.0 | 0.0 | Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. | G Bertani | J Bacteriol | 1951 | 14888646 | Yes |
| 914 | 5045 | 2522.5 | 137.7 | 68.8 | Acute-phase proteins and other systemic responses to inflammation. | C Gabay, I Kushner | N Engl J Med | 1999 | 9971870 | No |
| 915 | 2522 | 2522.0 | 93.6 | 93.6 | Human error: models and management. | J Reason | BMJ | 2000 | 10720363 | Yes |
| 916 | 2522 | 2522.0 | 47.0 | 47.0 | Wnt signaling and cancer. | P Polakis | Genes Dev | 2000 | 10921899 | No |
| 917 | 2521 | 2521.0 | 149.3 | 149.3 | The assessment of clinical skills/competence/performance. | G E Miller | Acad Med | 1990 | 2400509 | Yes |
| 918 | 2520 | 2520.0 | 62.7 | 62.7 | Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. | E C Butcher | Cell | 1991 | 1760836 | No |
| 919 | 2520 | 2520.0 | 56.6 | 56.6 | A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. | Douglas C Wallace | Annu Rev Genet | 2005 | 16285865 | No |
| 920 | 2518 | 2518.0 | 46.0 | 46.0 | Java Treeview--extensible visualization of microarray data. | Alok J Saldanha | Bioinformatics | 2004 | 15180930 | Yes |
| 921 | 2517 | 2517.0 | 77.0 | 77.0 | Matching methods for causal inference: A review and a look forward. | Elizabeth A Stuart | Stat Sci | 2010 | 20871802 | Yes |
| 922 | 2508 | 2508.0 | 79.8 | 79.8 | Secretory products of macrophages. | C F Nathan | J Clin Invest | 1987 | 3543052 | No |
| 923 | 5014 | 2507.0 | 113.7 | 56.9 | AKT/PKB signaling: navigating downstream. | Brendan D Manning, Lewis C Cantley | Cell | 2007 | 17604717 | No |
| 924 | 2504 | 2504.0 | 75.0 | 75.0 | Epidemiology of insomnia: what we know and what we still need to learn. | Maurice M Ohayon | Sleep Med Rev | 2002 | 12531146 | Yes |
| 925 | 7499 | 2499.7 | 171.1 | 57.0 | The biology of VEGF and its receptors. | Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter | Nat Med | 2003 | 12778165 | No |
| 926 | 2499 | 2499.0 | 58.1 | 58.1 | Gene finding in novel genomes. | Ian Korf | BMC Bioinformatics | 2004 | 15144565 | Yes |
| 927 | 4998 | 2499.0 | 126.0 | 63.0 | Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. | Michael T Lin, M Flint Beal | Nature | 2006 | 17051205 | No |
| 928 | 4991 | 2495.5 | 100.7 | 50.4 | The phosphatidylinositol 3-Kinase AKT pathway in human cancer. | Igor Vivanco, Charles L Sawyers | Nat Rev Cancer | 2002 | 12094235 | No |
| 929 | 4976 | 2488.0 | 139.8 | 69.9 | Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. | P J Fraker, J C Speck | Biochem Biophys Res Commun | 1978 | 637870 | Yes |
| 930 | 7461 | 2487.0 | 249.2 | 83.1 | Estimating the mean and variance from the median, range, and the size of a sample. | Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo | BMC Med Res Methodol | 2005 | 15840177 | Yes |
| 931 | 2486 | 2486.0 | 89.0 | 89.0 | Cognitive reserve in ageing and Alzheimer's disease. | Yaakov Stern | Lancet Neurol | 2012 | 23079557 | No |
| 932 | 4967 | 2483.5 | 103.5 | 51.8 | Lipid rafts and signal transduction. | K Simons, D Toomre | Nat Rev Mol Cell Biol | 2000 | 11413487 | No |
| 933 | 2482 | 2482.0 | 210.5 | 210.5 | Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. | Brent R Stockwell | Cell | 2022 | 35803244 | No |
| 934 | 2481 | 2481.0 | 49.0 | 49.0 | Getting started with yeast. | F Sherman | Methods Enzymol | 1991 | 2005794 | Yes |
| 935 | 2479 | 2479.0 | 72.6 | 72.6 | The importance of selenium to human health. | M P Rayman | Lancet | 2000 | 10963212 | No |
| 936 | 2479 | 2479.0 | 0.0 | 0.0 | Transduction of linked genetic characters of the host by bacteriophage P1. | E S Lennox | Virology | 1955 | 13267987 | Yes |
| 937 | 4956 | 2478.0 | 134.4 | 67.2 | A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. | Y Matsumura, H Maeda | Cancer Res | 1986 | 2946403 | Yes |
| 938 | 2473 | 2473.0 | 55.4 | 55.4 | Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. | T Hunter | Cell | 1995 | 7834742 | No |
| 939 | 2471 | 2471.0 | 86.7 | 86.7 | Oxygen-dependent microbial killing by phagocytes (first of two parts). | B M Babior | N Engl J Med | 1978 | 24176 | Yes |
| 940 | 2467 | 2467.0 | 52.0 | 52.0 | The lasso method for variable selection in the Cox model. | R Tibshirani | Stat Med | 1997 | 9044528 | Yes |
| 941 | 4932 | 2466.0 | 175.2 | 87.6 | Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. | Sarvajeet Singh Gill, Narendra Tuteja | Plant Physiol Biochem | 2010 | 20870416 | No |
| 942 | 4931 | 2465.5 | 120.7 | 60.4 | Protein misfolding, functional amyloid, and human disease. | Fabrizio Chiti, Christopher M Dobson | Annu Rev Biochem | 2006 | 16756495 | No |
| 943 | 2464 | 2464.0 | 80.8 | 80.8 | Scaffolds in tissue engineering bone and cartilage. | D W Hutmacher | Biomaterials | 2000 | 11071603 | Yes |
| 944 | 4926 | 2463.0 | 144.6 | 72.3 | Distributed hierarchical processing in the primate cerebral cortex. | D J Felleman, D C Van Essen | Cereb Cortex | 1991 | 1822724 | No |
| 945 | 7386 | 2462.0 | 229.8 | 76.6 | The brain's default network: anatomy, function, and relevance to disease. | Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter | Ann N Y Acad Sci | 2008 | 18400922 | No |
| 946 | 4923 | 2461.5 | 129.1 | 64.5 | The unfolded protein response: from stress pathway to homeostatic regulation. | Peter Walter, David Ron | Science | 2011 | 22116877 | No |
| 947 | 2460 | 2460.0 | 87.4 | 87.4 | Keratoconus. | Y S Rabinowitz | Surv Ophthalmol | 1998 | 9493273 | No |
| 948 | 2457 | 2457.0 | 119.4 | 119.4 | Presidential Address-1976. Social support as a moderator of life stress. | S Cobb | Psychosom Med | 1976 | 981490 | Yes |
| 949 | 2454 | 2454.0 | 57.6 | 57.6 | Specification of cerebral cortical areas. | P Rakic | Science | 1988 | 3291116 | No |
| 950 | 2453 | 2453.0 | 65.4 | 65.4 | Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. | H G Gratzner | Science | 1982 | 7123245 | Yes |
| 951 | 4894 | 2447.0 | 203.9 | 102.0 | Self-rated health and mortality: a review of twenty-seven community studies. | E L Idler, Y Benyamini | J Health Soc Behav | 1997 | 9097506 | No |
| 952 | 2446 | 2446.0 | 80.6 | 80.6 | Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. | F F Jobsis | Science | 1977 | 929199 | Yes |
| 953 | 2446 | 2446.0 | 53.9 | 53.9 | NOX enzymes and the biology of reactive oxygen. | J David Lambeth | Nat Rev Immunol | 2004 | 15039755 | No |
| 954 | 4891 | 2445.5 | 135.3 | 67.7 | Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. | M Matsuda, R A DeFronzo | Diabetes Care | 1999 | 10480510 | Yes |
| 955 | 2445 | 2445.0 | 55.7 | 55.7 | Social controls on cell survival and cell death. | M C Raff | Nature | 1992 | 1557121 | No |
| 956 | 4889 | 2444.5 | 266.6 | 133.3 | ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. | Emmanuel Paradis, Klaus Schliep | Bioinformatics | 2019 | 30016406 | Yes |
| 957 | 4888 | 2444.0 | 189.5 | 94.8 | The attention system of the human brain. | M I Posner, S E Petersen | Annu Rev Neurosci | 1990 | 2183676 | No |
| 958 | 4883 | 2441.5 | 179.8 | 89.9 | ROS function in redox signaling and oxidative stress. | Michael Schieber, Navdeep S Chandel | Curr Biol | 2014 | 24845678 | No |
| 959 | 2440 | 2440.0 | 56.5 | 56.5 | Mitochondrial diseases in man and mouse. | D C Wallace | Science | 1999 | 10066162 | No |
| 960 | 2436 | 2436.0 | 66.7 | 66.7 | A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. | P Chomczynski | Biotechniques | 1993 | 7692896 | Yes |
| 961 | 4868 | 2434.0 | 106.2 | 53.1 | New functions for the matrix metalloproteinases in cancer progression. | Mikala Egeblad, Zena Werb | Nat Rev Cancer | 2002 | 11990853 | No |
| 962 | 2433 | 2433.0 | 53.6 | 53.6 | Molecular physiology of P2X receptors. | R Alan North | Physiol Rev | 2002 | 12270951 | No |
| 963 | 4866 | 2433.0 | 208.3 | 104.2 | Methods for the thematic synthesis of qualitative research in systematic reviews. | James Thomas, Angela Harden | BMC Med Res Methodol | 2008 | 18616818 | Yes |
| 964 | 4864 | 2432.0 | 97.1 | 48.5 | Mechanisms of TGF-beta signaling from cell membrane to the nucleus. | Yigong Shi, Joan Massague | Cell | 2003 | 12809600 | No |
| 965 | 9724 | 2431.0 | 244.0 | 61.0 | Matrix elasticity directs stem cell lineage specification. | Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher | Cell | 2006 | 16923388 | Yes |
| 966 | 4855 | 2427.5 | 132.2 | 66.1 | Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. | C W Elston, I O Ellis | Histopathology | 1991 | 1757079 | Yes |
| 967 | 4853 | 2426.5 | 150.2 | 75.1 | Mechanisms of salinity tolerance. | Rana Munns, Mark Tester | Annu Rev Plant Biol | 2008 | 18444910 | No |
| 968 | 2425 | 2425.0 | 0.0 | 0.0 | Muscle structure and theories of contraction. | A F Huxley | Prog Biophys Biophys Chem | 1957 | 13485191 | Yes |
| 969 | 7260 | 2420.0 | 0.0 | 0.0 | On The Nature Of Allosteric Transitions: A Plausible Model. | J Monod, J Wyman, J P Changeux | J Mol Biol | 1965 | 14343300 | Yes |
| 970 | 2418 | 2418.0 | 101.2 | 101.2 | Approximate entropy as a measure of system complexity. | S M Pincus | Proc Natl Acad Sci U S A | 1991 | 11607165 | Yes |
| 971 | 2417 | 2417.0 | 57.1 | 57.1 | A decade of molecular biology of retinoic acid receptors. | P Chambon | FASEB J | 1996 | 8801176 | No |
| 972 | 4832 | 2416.0 | 0.0 | 0.0 | Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. | R L Heath, L Packer | Arch Biochem Biophys | 1968 | 5655425 | Yes |
| 973 | 2416 | 2416.0 | 83.6 | 83.6 | Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? | George A Bonanno | Am Psychol | 2004 | 14736317 | No |
| 974 | 2416 | 2416.0 | 70.0 | 70.0 | phangorn: phylogenetic analysis in R. | Klaus Peter Schliep | Bioinformatics | 2011 | 21169378 | Yes |
| 975 | 2414 | 2414.0 | 62.4 | 62.4 | Ischemic cell death in brain neurons. | P Lipton | Physiol Rev | 1999 | 10508238 | No |
| 976 | 2414 | 2414.0 | 82.9 | 82.9 | A new automated colorimetric method for measuring total oxidant status. | Ozcan Erel | Clin Biochem | 2005 | 16214125 | Yes |
| 977 | 7235 | 2411.7 | 246.6 | 82.2 | Complex heatmaps reveal patterns and correlations in multidimensional genomic data. | Zuguang Gu, Roland Eils, Matthias Schlesner | Bioinformatics | 2016 | 27207943 | Yes |
| 978 | 4823 | 2411.5 | 133.0 | 66.5 | Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. | Marie-Christine Daniel, Didier Astruc | Chem Rev | 2004 | 14719978 | No |
| 979 | 7234 | 2411.3 | 207.5 | 69.2 | Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. | F E Harrell, K L Lee, D B Mark | Stat Med | 1996 | 8668867 | No |
| 980 | 4819 | 2409.5 | 138.9 | 69.5 | Extended-connectivity fingerprints. | David Rogers, Mathew Hahn | J Chem Inf Model | 2010 | 20426451 | Yes |
| 981 | 4818 | 2409.0 | 105.2 | 52.6 | Mass spectrometry-based proteomics. | Ruedi Aebersold, Matthias Mann | Nature | 2003 | 12634793 | No |
| 982 | 2409 | 2409.0 | 73.1 | 73.1 | Trail Making Test A and B: normative data stratified by age and education. | Tom N Tombaugh | Arch Clin Neuropsychol | 2004 | 15010086 | Yes |
| 983 | 2409 | 2409.0 | 52.2 | 52.2 | Maintenance of C. elegans. | Theresa Stiernagle | WormBook | 2006 | 18050451 | No |
| 984 | 2406 | 2406.0 | 74.5 | 74.5 | The episodic buffer: a new component of working memory? | A Baddeley | Trends Cogn Sci | 2000 | 11058819 | Yes |
| 985 | 4809 | 2404.5 | 128.9 | 64.5 | Measuring the thickness of the human cerebral cortex from magnetic resonance images. | B Fischl, A M Dale | Proc Natl Acad Sci U S A | 2000 | 10984517 | Yes |
| 986 | 4807 | 2403.5 | 204.7 | 102.3 | The Health Belief Model: a decade later. | N K Janz, M H Becker | Health Educ Q | 1984 | 6392204 | No |
| 987 | 4805 | 2402.5 | 218.2 | 109.1 | Sensitivity Analysis in Observational Research: Introducing the E-Value. | Tyler J VanderWeele, Peng Ding | Ann Intern Med | 2017 | 28693043 | Yes |
| 988 | 2402 | 2402.0 | 72.7 | 72.7 | Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. | Berislav V Zlokovic | Nat Rev Neurosci | 2011 | 22048062 | No |
| 989 | 4803 | 2401.5 | 91.9 | 46.0 | A novel genetic system to detect protein-protein interactions. | S Fields, O Song | Nature | 1989 | 2547163 | Yes |
| 990 | 4803 | 2401.5 | 126.6 | 63.3 | The inflammasomes. | Kate Schroder, Jurg Tschopp | Cell | 2010 | 20303873 | No |
| 991 | 2401 | 2401.0 | 49.8 | 49.8 | The molecular biology of memory storage: a dialogue between genes and synapses. | E R Kandel | Science | 2001 | 11691980 | No |
| 992 | 2397 | 2397.0 | 51.7 | 51.7 | Comparison of the predicted and observed secondary structure of T4 phage lysozyme. | B W Matthews | Biochim Biophys Acta | 1975 | 1180967 | Yes |
| 993 | 2397 | 2397.0 | 80.8 | 80.8 | Pro-resolving lipid mediators are leads for resolution physiology. | Charles N Serhan | Nature | 2014 | 24899309 | No |
| 994 | 2395 | 2395.0 | 95.3 | 95.3 | The Michigan alcoholism screening test: the quest for a new diagnostic instrument. | M L Selzer | Am J Psychiatry | 1971 | 5565851 | Yes |
| 995 | 2394 | 2394.0 | 54.6 | 54.6 | Theta oscillations in the hippocampus. | Gyorgy Buzsaki | Neuron | 2002 | 11832222 | No |
| 996 | 4783 | 2391.5 | 184.4 | 92.2 | Sex differences in immune responses. | Sabra L Klein, Katie L Flanagan | Nat Rev Immunol | 2016 | 27546235 | No |
| 997 | 2391 | 2391.0 | 45.6 | 45.6 | Shelterin: the protein complex that shapes and safeguards human telomeres. | Titia De Lange | Genes Dev | 2005 | 16166375 | No |
| 998 | 7161 | 2387.0 | 156.4 | 52.1 | EMBOSS: the European Molecular Biology Open Software Suite. | P Rice, I Longden, A Bleasby | Trends Genet | 2000 | 10827456 | Yes |
| 999 | 4771 | 2385.5 | 0.0 | 0.0 | Variations in pattern of pubertal changes in girls. | W A Marshall, J M Tanner | Arch Dis Child | 1969 | 5785179 | Yes |
| 1000 | 2382 | 2382.0 | 88.1 | 88.1 | Macrophage Polarization. | Peter J Murray | Annu Rev Physiol | 2017 | 27813830 | No |
| 1001 | 7138 | 2379.3 | 178.7 | 59.6 | APE: Analyses of Phylogenetics and Evolution in R language. | Emmanuel Paradis, Julien Claude, Korbinian Strimmer | Bioinformatics | 2004 | 14734327 | Yes |
| 1002 | 2379 | 2379.0 | 83.3 | 83.3 | Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. | W A Craig | Clin Infect Dis | 1998 | 9455502 | No |
| 1003 | 4754 | 2377.0 | 210.9 | 105.5 | A simple practice guide for dose conversion between animals and human. | Anroop B Nair, Shery Jacob | J Basic Clin Pharm | 2016 | 27057123 | No |
| 1004 | 26139 | 2376.3 | 676.2 | 61.5 | PLINK: a tool set for whole-genome association and population-based linkage analyses. | Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W De Bakker, Mark J Daly, Pak C Sham | Am J Hum Genet | 2007 | 17701901 | Yes |
| 1005 | 4752 | 2376.0 | 92.6 | 46.3 | SIFT: Predicting amino acid changes that affect protein function. | Pauline C Ng, Steven Henikoff | Nucleic Acids Res | 2003 | 12824425 | Yes |
| 1006 | 4745 | 2372.5 | 212.6 | 106.3 | The MOS social support survey. | C D Sherbourne, A L Stewart | Soc Sci Med | 1991 | 2035047 | Yes |
| 1007 | 4744 | 2372.0 | 109.4 | 54.7 | Death receptors: signaling and modulation. | A Ashkenazi, V M Dixit | Science | 1998 | 9721089 | No |
| 1008 | 2371 | 2371.0 | 77.2 | 77.2 | Biodiesel from microalgae. | Yusuf Chisti | Biotechnol Adv | 2007 | 17350212 | No |
| 1009 | 2365 | 2365.0 | 78.6 | 78.6 | A rapid radiochemical method for the determination of choline acetyltransferase. | F Fonnum | J Neurochem | 1975 | 1113118 | Yes |
| 1010 | 2365 | 2365.0 | 79.7 | 79.7 | Modeling Development and Disease with Organoids. | Hans Clevers | Cell | 2016 | 27315476 | No |
| 1011 | 2363 | 2363.0 | 52.7 | 52.7 | Stereochemistry of cooperative effects in haemoglobin. | M F Perutz | Nature | 1970 | 5528785 | Yes |
| 1012 | 4721 | 2360.5 | 0.0 | 0.0 | On the size of the active site in proteases. I. Papain. | I Schechter, A Berger | Biochem Biophys Res Commun | 1967 | 6035483 | Yes |
| 1013 | 2360 | 2360.0 | 60.7 | 60.7 | A model for receptor-regulated calcium entry. | J W Putney | Cell Calcium | 1986 | 2420465 | No |
| 1014 | 4719 | 2359.5 | 86.4 | 43.2 | The interpretation of protein structures: estimation of static accessibility. | B Lee, F M Richards | J Mol Biol | 1971 | 5551392 | Yes |
| 1015 | 2359 | 2359.0 | 60.8 | 60.8 | RGD and other recognition sequences for integrins. | E Ruoslahti | Annu Rev Cell Dev Biol | 1996 | 8970741 | No |
| 1016 | 2358 | 2358.0 | 89.4 | 89.4 | Specific impairments of planning. | T Shallice | Philos Trans R Soc Lond B Biol Sci | 1982 | 6125971 | Yes |
| 1017 | 18841 | 2355.1 | 593.8 | 74.2 | The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. | Ziad S Nasreddine, Natalie A Phillips, Valerie Bedirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow | J Am Geriatr Soc | 2005 | 15817019 | Yes |
| 1018 | 2355 | 2355.0 | 53.2 | 53.2 | The structure and regulation of protein phosphatases. | P Cohen | Annu Rev Biochem | 1989 | 2549856 | No |
| 1019 | 2354 | 2354.0 | 56.6 | 56.6 | The anatomy and taxonomy of protein structure. | J S Richardson | Adv Protein Chem | 1981 | 7020376 | No |
| 1020 | 2351 | 2351.0 | 62.9 | 62.9 | Accurate description of van der Waals complexes by density functional theory including empirical corrections. | Stefan Grimme | J Comput Chem | 2004 | 15224390 | Yes |
| 1021 | 7052 | 2350.7 | 198.8 | 66.3 | Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. | Helga Thorvaldsdottir, James T Robinson, Jill P Mesirov | Brief Bioinform | 2013 | 22517427 | Yes |
| 1022 | 2350 | 2350.0 | 44.9 | 44.9 | Histone acetylation in chromatin structure and transcription. | M Grunstein | Nature | 1997 | 9311776 | No |
| 1023 | 2349 | 2349.0 | 62.8 | 62.8 | Drug-like properties and the causes of poor solubility and poor permeability. | C A Lipinski | J Pharmacol Toxicol Methods | 2000 | 11274893 | No |
| 1024 | 2347 | 2347.0 | 60.1 | 60.1 | Pancreatic cancer. | Manuel Hidalgo | N Engl J Med | 2010 | 20427809 | No |
| 1025 | 2345 | 2345.0 | 69.6 | 69.6 | Interleukin-1 and interleukin-1 antagonism. | C A Dinarello | Blood | 1991 | 1826616 | No |
| 1026 | 2345 | 2345.0 | 70.8 | 70.8 | Global epidemiology of oral and oropharyngeal cancer. | Saman Warnakulasuriya | Oral Oncol | 2009 | 18804401 | No |
| 1027 | 4688 | 2344.0 | 120.1 | 60.0 | A receptor-mediated pathway for cholesterol homeostasis. | M S Brown, J L Goldstein | Science | 1986 | 3513311 | No |
| 1028 | 2344 | 2344.0 | 104.8 | 104.8 | Hydrogel: Preparation, characterization, and applications: A review. | Enas M Ahmed | J Adv Res | 2015 | 25750745 | No |
| 1029 | 4687 | 2343.5 | 130.5 | 65.2 | Wnt/β-catenin signaling and disease. | Hans Clevers, Roel Nusse | Cell | 2012 | 22682243 | No |
| 1030 | 7029 | 2343.0 | 211.5 | 70.5 | Glucose clamp technique: a method for quantifying insulin secretion and resistance. | R A DeFronzo, J D Tobin, R Andres | Am J Physiol | 1979 | 382871 | Yes |
| 1031 | 4681 | 2340.5 | 121.3 | 60.6 | Building better batteries. | M Armand, J M Tarascon | Nature | 2008 | 18256660 | No |
| 1032 | 4670 | 2335.0 | 101.9 | 51.0 | Screening lambdagt recombinant clones by hybridization to single plaques in situ. | W D Benton, R W Davis | Science | 1977 | 322279 | Yes |
| 1033 | 4668 | 2334.0 | 183.1 | 91.5 | Parkinson's disease. | Lorraine V Kalia, Anthony E Lang | Lancet | 2015 | 25904081 | No |
| 1034 | 2333 | 2333.0 | 75.4 | 75.4 | Fetal origins of coronary heart disease. | D J Barker | BMJ | 1995 | 7613432 | No |
| 1035 | 2332 | 2332.0 | 54.9 | 54.9 | A clearer vision for in vivo imaging. | R Weissleder | Nat Biotechnol | 2001 | 11283581 | No |
| 1036 | 2331 | 2331.0 | 97.4 | 97.4 | Role of Streptococcus mutans in human dental decay. | W J Loesche | Microbiol Rev | 1986 | 3540569 | No |
| 1037 | 2331 | 2331.0 | 77.9 | 77.9 | Calmodulin plays a pivotal role in cellular regulation. | W Y Cheung | Science | 1980 | 6243188 | No |
| 1038 | 4661 | 2330.5 | 100.4 | 50.2 | Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. | T V Bliss, T Lomo | J Physiol | 1973 | 4727084 | Yes |
| 1039 | 2330 | 2330.0 | 77.1 | 77.1 | Reactive oxygen species and the central nervous system. | B Halliwell | J Neurochem | 1992 | 1402908 | No |
| 1040 | 2327 | 2327.0 | 119.4 | 119.4 | Subjective well-being. | E Diener | Psychol Bull | 1984 | 6399758 | No |
| 1041 | 2327 | 2327.0 | 0.0 | 0.0 | Analysis of tissue and arterial blood temperatures in the resting human forearm. | H H Pennes | J Appl Physiol | 1948 | 18887578 | Yes |
| 1042 | 2326 | 2326.0 | 66.0 | 66.0 | What is cognitive reserve? Theory and research application of the reserve concept. | Yaakov Stern | J Int Neuropsychol Soc | 2002 | 11939702 | No |
| 1043 | 2322 | 2322.0 | 62.9 | 62.9 | Inositol phospholipids and cell surface receptor function. | R H Michell | Biochim Biophys Acta | 1975 | 164246 | No |
| 1044 | 2322 | 2322.0 | 66.3 | 66.3 | Descending control of pain. | Mark J Millan | Prog Neurobiol | 2002 | 12034378 | No |
| 1045 | 2321 | 2321.0 | 60.0 | 60.0 | Dopamine, learning and motivation. | Roy A Wise | Nat Rev Neurosci | 2004 | 15152198 | No |
| 1046 | 4641 | 2320.5 | 0.0 | 0.0 | Loss of recent memory after bilateral hippocampal lesions. | W B Scoville, B Milner | J Neurol Neurosurg Psychiatry | 1957 | 13406589 | Yes |
| 1047 | 4639 | 2319.5 | 125.5 | 62.8 | Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. | R A Laskey, A D Mills | Eur J Biochem | 1975 | 1175627 | Yes |
| 1048 | 4639 | 2319.5 | 93.5 | 46.8 | Smad-dependent and Smad-independent pathways in TGF-beta family signalling. | Rik Derynck, Ying E Zhang | Nature | 2003 | 14534577 | No |
| 1049 | 4639 | 2319.5 | 104.2 | 52.1 | The DNA-damage response in human biology and disease. | Stephen P Jackson, Jiri Bartek | Nature | 2009 | 19847258 | No |
| 1050 | 2317 | 2317.0 | 66.7 | 66.7 | Hybrid porous solids: past, present, future. | Gerard Ferey | Chem Soc Rev | 2008 | 18197340 | Yes |
| 1051 | 4632 | 2316.0 | 112.8 | 56.4 | Regulation of the mevalonate pathway. | J L Goldstein, M S Brown | Nature | 1990 | 1967820 | No |
| 1052 | 9257 | 2314.2 | 380.0 | 95.0 | jModelTest 2: more models, new heuristics and parallel computing. | Diego Darriba, Guillermo L Taboada, Ramon Doallo, David Posada | Nat Methods | 2012 | 22847109 | Yes |
| 1053 | 2313 | 2313.0 | 51.7 | 51.7 | Follicular helper CD4 T cells (TFH). | Shane Crotty | Annu Rev Immunol | 2011 | 21314428 | No |
| 1054 | 4620 | 2310.0 | 190.0 | 95.0 | The amyloid hypothesis of Alzheimer's disease at 25Â years. | Dennis J Selkoe, John Hardy | EMBO Mol Med | 2016 | 27025652 | No |
| 1055 | 2308 | 2308.0 | 71.5 | 71.5 | Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. | R A DeFronzo | Diabetes | 1988 | 3289989 | No |
| 1056 | 4616 | 2308.0 | 0.0 | 0.0 | High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. | M N Berry, D S Friend | J Cell Biol | 1969 | 4900611 | Yes |
| 1057 | 2307 | 2307.0 | 115.4 | 115.4 | Stop Explaining Black Box Machine Learning Models for High Stakes Decisions and Use Interpretable Models Instead. | Cynthia Rudin | Nat Mach Intell | 2019 | 35603010 | Yes |
| 1058 | 2304 | 2304.0 | 59.1 | 59.1 | Bcl-2 and the regulation of programmed cell death. | J C Reed | J Cell Biol | 1994 | 8294493 | No |
| 1059 | 2304 | 2304.0 | 58.5 | 58.5 | Metabolomics--the link between genotypes and phenotypes. | Oliver Fiehn | Plant Mol Biol | 2002 | 11860207 | No |
| 1060 | 2302 | 2302.0 | 59.1 | 59.1 | Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. | Gokhan S Hotamisligil | Cell | 2010 | 20303879 | No |
| 1061 | 2296 | 2296.0 | 55.3 | 55.3 | Pathways towards and away from Alzheimer's disease. | Mark P Mattson | Nature | 2004 | 15295589 | No |
| 1062 | 4590 | 2295.0 | 140.6 | 70.3 | EQ-5D: a measure of health status from the EuroQol Group. | R Rabin, F De Charro | Ann Med | 2001 | 11491192 | No |
| 1063 | 2294 | 2294.0 | 52.1 | 52.1 | Complement. First of two parts. | M J Walport | N Engl J Med | 2001 | 11287977 | No |
| 1064 | 4585 | 2292.5 | 174.5 | 87.2 | ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. | M Gardes, T D Bruns | Mol Ecol | 1993 | 8180733 | Yes |
| 1065 | 2288 | 2288.0 | 77.4 | 77.4 | Grounded cognition. | Lawrence W Barsalou | Annu Rev Psychol | 2008 | 17705682 | No |
| 1066 | 11439 | 2287.8 | 372.8 | 74.6 | The hallmarks of aging. | Carlos Lopez-Otin, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer | Cell | 2013 | 23746838 | No |
| 1067 | 2286 | 2286.0 | 100.9 | 100.9 | The Children's Depression, Inventory (CDI). | M Kovacs | Psychopharmacol Bull | 1985 | 4089116 | Yes |
| 1068 | 2284 | 2284.0 | 66.4 | 66.4 | Superoxide radical and superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1995 | 7574505 | No |
| 1069 | 2283 | 2283.0 | 80.9 | 80.9 | Glutamate, nitric oxide and cell-cell signalling in the nervous system. | J Garthwaite | Trends Neurosci | 1991 | 1708538 | No |
| 1070 | 2283 | 2283.0 | 45.3 | 45.3 | SV40-transformed simian cells support the replication of early SV40 mutants. | Y Gluzman | Cell | 1981 | 6260373 | Yes |
| 1071 | 2283 | 2283.0 | 0.0 | 0.0 | [Rapid physiological coagulation method in determination of fibrinogen]. | A Clauss | Acta Haematol | 1957 | 13434757 | Yes |
| 1072 | 13688 | 2281.3 | 313.0 | 52.2 | NMRPipe: a multidimensional spectral processing system based on UNIX pipes. | F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax | J Biomol NMR | 1995 | 8520220 | Yes |
| 1073 | 6842 | 2280.7 | 224.4 | 74.8 | Management of hepatocellular carcinoma: an update. | Jordi Bruix, Morris Sherman, | Hepatology | 2011 | 21374666 | No |
| 1074 | 2278 | 2278.0 | 65.6 | 65.6 | Aging, cellular senescence, and cancer. | Judith Campisi | Annu Rev Physiol | 2013 | 23140366 | No |
| 1075 | 4553 | 2276.5 | 90.4 | 45.2 | Network biology: understanding the cell's functional organization. | Albert-Laszlo Barabasi, Zoltan N Oltvai | Nat Rev Genet | 2004 | 14735121 | No |
| 1076 | 2276 | 2276.0 | 54.2 | 54.2 | Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. | Scott L Friedman | Physiol Rev | 2008 | 18195085 | No |
| 1077 | 4550 | 2275.0 | 113.9 | 57.0 | Neuronal oscillations in cortical networks. | Gyorgy Buzsaki, Andreas Draguhn | Science | 2004 | 15218136 | No |
| 1078 | 2274 | 2274.0 | 70.7 | 70.7 | Determination of minimum inhibitory concentrations. | J M Andrews | J Antimicrob Chemother | 2001 | 11420333 | Yes |
| 1079 | 6821 | 2273.7 | 241.0 | 80.3 | Multiple imputation using chained equations: Issues and guidance for practice. | Ian R White, Patrick Royston, Angela M Wood | Stat Med | 2011 | 21225900 | Yes |
| 1080 | 2273 | 2273.0 | 90.5 | 90.5 | Optical properties of biological tissues: a review. | Steven L Jacques | Phys Med Biol | 2013 | 23666068 | No |
| 1081 | 4545 | 2272.5 | 87.3 | 43.6 | The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. | J A Spudich, S Watt | J Biol Chem | 1971 | 4254541 | Yes |
| 1082 | 2271 | 2271.0 | 0.0 | 0.0 | The Gingival Index, the Plaque Index and the Retention Index Systems. | H Loe | J Periodontol | 1967 | 5237684 | Yes |
| 1083 | 4541 | 2270.5 | 146.1 | 73.0 | A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. | Gary J Bennett, Y K Xie | Pain | 1988 | 2837713 | Yes |
| 1084 | 15890 | 2270.0 | 484.8 | 69.3 | AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. | Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson | J Comput Chem | 2009 | 19399780 | Yes |
| 1085 | 2270 | 2270.0 | 89.3 | 89.3 | Whatever next? Predictive brains, situated agents, and the future of cognitive science. | Andy Clark | Behav Brain Sci | 2013 | 23663408 | No |
| 1086 | 4537 | 2268.5 | 106.2 | 53.1 | Issues and challenges facing rechargeable lithium batteries. | J M Tarascon, M Armand | Nature | 2001 | 11713543 | Yes |
| 1087 | 2268 | 2268.0 | 60.6 | 60.6 | The molecular pathology of Alzheimer's disease. | D J Selkoe | Neuron | 1991 | 1673054 | No |
| 1088 | 4536 | 2268.0 | 110.8 | 55.4 | Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. | Hashem B El-Serag, K Lenhard Rudolph | Gastroenterology | 2007 | 17570226 | No |
| 1089 | 15865 | 2266.4 | 498.8 | 71.3 | The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. | Erik Von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gotzsche, Jan P Vandenbroucke, | Lancet | 2007 | 18064739 | Yes |
| 1090 | 4532 | 2266.0 | 142.9 | 71.5 | Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9167458 | Yes |
| 1091 | 2265 | 2265.0 | 58.3 | 58.3 | Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. | Edward V Loftus | Gastroenterology | 2004 | 15168363 | Yes |
| 1092 | 2264 | 2264.0 | 60.5 | 60.5 | Systemic lupus erythematosus. | George C Tsokos | N Engl J Med | 2011 | 22129255 | No |
| 1093 | 2262 | 2262.0 | 82.7 | 82.7 | Selenium and human health. | Margaret P Rayman | Lancet | 2012 | 22381456 | No |
| 1094 | 2260 | 2260.0 | 46.7 | 46.7 | Intracellular aspects of the process of protein synthesis. | G Palade | Science | 1975 | 1096303 | No |
| 1095 | 4518 | 2259.0 | 0.0 | 0.0 | A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. | J E Till, E A McCULLOCH | Radiat Res | 1961 | 13776896 | Yes |
| 1096 | 2259 | 2259.0 | 0.0 | 0.0 | Application of a microtechnique to viral serological investigations. | J L Sever | J Immunol | 1962 | 13910995 | Yes |
| 1097 | 2257 | 2257.0 | 56.5 | 56.5 | Pathogen recognition and inflammatory signaling in innate immune defenses. | Trine H Mogensen | Clin Microbiol Rev | 2009 | 19366914 | No |
| 1098 | 2253 | 2253.0 | 91.7 | 91.7 | Perception of risk. | P Slovic | Science | 1987 | 3563507 | Yes |
| 1099 | 2253 | 2253.0 | 55.5 | 55.5 | Protein kinase C and lipid signaling for sustained cellular responses. | Y Nishizuka | FASEB J | 1995 | 7737456 | No |
| 1100 | 4506 | 2253.0 | 101.1 | 50.5 | ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. | Matthew D Wilkerson, D Neil Hayes | Bioinformatics | 2010 | 20427518 | Yes |
| 1101 | 4501 | 2250.5 | 159.0 | 79.5 | The Emerging Hallmarks of Cancer Metabolism. | Natalya N Pavlova, Craig B Thompson | Cell Metab | 2016 | 26771115 | No |
| 1102 | 2250 | 2250.0 | 88.6 | 88.6 | Electroimmuno assay. | C B Laurell | Scand J Clin Lab Invest Suppl | 1972 | 4114358 | Yes |
| 1103 | 2250 | 2250.0 | 89.3 | 89.3 | International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. | C Herrmann | J Psychosom Res | 1997 | 9055211 | No |
| 1104 | 4497 | 2248.5 | 104.6 | 52.3 | A simple and very efficient method for generating cDNA libraries. | U Gubler, B J Hoffman | Gene | 1983 | 6198242 | Yes |
| 1105 | 2246 | 2246.0 | 57.4 | 57.4 | Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. | J Kyhse-Andersen | J Biochem Biophys Methods | 1984 | 6530509 | Yes |
| 1106 | 4491 | 2245.5 | 95.4 | 47.7 | 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? | George Davey Smith, Shah Ebrahim | Int J Epidemiol | 2003 | 12689998 | No |
| 1107 | 8977 | 2244.2 | 420.4 | 105.1 | Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. | Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun Tong | BMC Med Res Methodol | 2014 | 25524443 | Yes |
| 1108 | 2243 | 2243.0 | 64.0 | 64.0 | Molecular diversity of glutamate receptors and implications for brain function. | S Nakanishi | Science | 1992 | 1329206 | No |
| 1109 | 2243 | 2243.0 | 79.5 | 79.5 | Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. | B N Ames | Science | 1983 | 6351251 | No |
| 1110 | 2242 | 2242.0 | 58.7 | 58.7 | Python: a programming language for software integration and development. | M F Sanner | J Mol Graph Model | 1999 | 10660911 | Yes |
| 1111 | 2241 | 2241.0 | 77.6 | 77.6 | A classification of glycosyl hydrolases based on amino acid sequence similarities. | B Henrissat | Biochem J | 1991 | 1747104 | Yes |
| 1112 | 2239 | 2239.0 | 50.6 | 50.6 | The regulation of AP-1 activity by mitogen-activated protein kinases. | M Karin | J Biol Chem | 1995 | 7622446 | No |
| 1113 | 2236 | 2236.0 | 67.9 | 67.9 | Diagnosis of Alzheimer's disease. | Z S Khachaturian | Arch Neurol | 1985 | 2864910 | Yes |
| 1114 | 2234 | 2234.0 | 74.4 | 74.4 | Cognitive reserve. | Yaakov Stern | Neuropsychologia | 2009 | 19467352 | No |
| 1115 | 8932 | 2233.0 | 222.9 | 55.7 | Cancer-related inflammation. | Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill | Nature | 2008 | 18650914 | No |
| 1116 | 4465 | 2232.5 | 135.2 | 67.6 | LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. | Roman A Laskowski, Mark B Swindells | J Chem Inf Model | 2011 | 21919503 | Yes |
| 1117 | 2232 | 2232.0 | 95.9 | 95.9 | A systematic method for clinical description and classification of personality variants. A proposal. | C R Cloninger | Arch Gen Psychiatry | 1987 | 3579504 | Yes |
| 1118 | 4464 | 2232.0 | 105.6 | 52.8 | The Bcl-2 protein family: arbiters of cell survival. | J M Adams, S Cory | Science | 1998 | 9735050 | No |
| 1119 | 4455 | 2227.5 | 131.0 | 65.5 | Genome editing. The new frontier of genome engineering with CRISPR-Cas9. | Jennifer A Doudna, Emmanuelle Charpentier | Science | 2014 | 25430774 | No |
| 1120 | 4454 | 2227.0 | 138.5 | 69.2 | Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. | Stephen M Smith, Thomas E Nichols | Neuroimage | 2009 | 18501637 | Yes |
| 1121 | 6681 | 2227.0 | 414.8 | 138.3 | Sample Size in Qualitative Interview Studies: Guided by Information Power. | Kirsti Malterud, Volkert Dirk Siersma, Ann Dorrit Guassora | Qual Health Res | 2016 | 26613970 | Yes |
| 1122 | 4452 | 2226.0 | 98.6 | 49.3 | Organization and expression of eucaryotic split genes coding for proteins. | R Breathnach, P Chambon | Annu Rev Biochem | 1981 | 6791577 | No |
| 1123 | 2226 | 2226.0 | 82.2 | 82.2 | AliView: a fast and lightweight alignment viewer and editor for large datasets. | Anders Larsson | Bioinformatics | 2014 | 25095880 | Yes |
| 1124 | 8898 | 2224.5 | 238.4 | 59.6 | Improved optimization for the robust and accurate linear registration and motion correction of brain images. | Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith | Neuroimage | 2002 | 12377157 | Yes |
| 1125 | 11122 | 2224.4 | 537.5 | 107.5 | ModelFinder: fast model selection for accurate phylogenetic estimates. | Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt Von Haeseler, Lars S Jermiin | Nat Methods | 2017 | 28481363 | Yes |
| 1126 | 2222 | 2222.0 | 54.6 | 54.6 | Mechanisms and genes of cellular suicide. | H Steller | Science | 1995 | 7878463 | No |
| 1127 | 6666 | 2222.0 | 280.8 | 93.6 | Shedding light on the cell biology of extracellular vesicles. | Guillaume Van Niel, Gisela D'Angelo, Graca Raposo | Nat Rev Mol Cell Biol | 2018 | 29339798 | No |
| 1128 | 2221 | 2221.0 | 87.3 | 87.3 | Mechanisms of action of transmitters and other substances on smooth muscle. | T B Bolton | Physiol Rev | 1979 | 37533 | No |
| 1129 | 2221 | 2221.0 | 71.1 | 71.1 | Flavonoids as antioxidants. | P G Pietta | J Nat Prod | 2000 | 10924197 | No |
| 1130 | 2221 | 2221.0 | 89.4 | 89.4 | Machine Learning in Medicine. | Rahul C Deo | Circulation | 2015 | 26572668 | No |
| 1131 | 4439 | 2219.5 | 133.2 | 66.6 | Polymyositis and dermatomyositis (first of two parts). | A Bohan, J B Peter | N Engl J Med | 1975 | 1090839 | No |
| 1132 | 4439 | 2219.5 | 315.0 | 157.5 | Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. | David J Newman, Gordon M Cragg | J Nat Prod | 2020 | 32162523 | No |
| 1133 | 2219 | 2219.0 | 51.0 | 51.0 | Defensins: antimicrobial peptides of innate immunity. | Tomas Ganz | Nat Rev Immunol | 2003 | 12949495 | No |
| 1134 | 6655 | 2218.3 | 219.4 | 73.1 | Molecular mechanisms of epithelial-mesenchymal transition. | Samy Lamouille, Jian Xu, Rik Derynck | Nat Rev Mol Cell Biol | 2014 | 24556840 | No |
| 1135 | 4435 | 2217.5 | 104.5 | 52.2 | Liver fibrosis. | Ramon Bataller, David A Brenner | J Clin Invest | 2005 | 15690074 | No |
| 1136 | 2215 | 2215.0 | 80.4 | 80.4 | Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. | H W Steinbusch | Neuroscience | 1981 | 7017455 | Yes |
| 1137 | 2215 | 2215.0 | 74.1 | 74.1 | Functional and effective connectivity: a review. | Karl J Friston | Brain Connect | 2011 | 22432952 | No |
| 1138 | 6642 | 2214.0 | 174.6 | 58.2 | GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. | R A Jefferson, T A Kavanagh, M W Bevan | EMBO J | 1987 | 3327686 | Yes |
| 1139 | 8852 | 2213.0 | 307.5 | 76.9 | Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. | A J Hughes, S E Daniel, L Kilford, A J Lees | J Neurol Neurosurg Psychiatry | 1992 | 1564476 | Yes |
| 1140 | 2211 | 2211.0 | 72.0 | 72.0 | The emerging role of lncRNAs in cancer. | Maite Huarte | Nat Med | 2015 | 26540387 | No |
| 1141 | 4417 | 2208.5 | 170.4 | 85.2 | Pain assessment: global use of the Brief Pain Inventory. | C S Cleeland, K M Ryan | Ann Acad Med Singap | 1994 | 8080219 | No |
| 1142 | 4417 | 2208.5 | 86.1 | 43.0 | The fundamental role of epigenetic events in cancer. | Peter A Jones, Stephen B Baylin | Nat Rev Genet | 2002 | 12042769 | No |
| 1143 | 2208 | 2208.0 | 59.0 | 59.0 | Episodic memory: from mind to brain. | Endel Tulving | Annu Rev Psychol | 2002 | 11752477 | Yes |
| 1144 | 2207 | 2207.0 | 0.0 | 0.0 | Removal of fatty acids from serum albumin by charcoal treatment. | R F Chen | J Biol Chem | 1967 | 6016603 | Yes |
| 1145 | 6620 | 2206.7 | 198.1 | 66.0 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. | C E Murry, R B Jennings, K A Reimer | Circulation | 1986 | 3769170 | Yes |
| 1146 | 15447 | 2206.7 | 442.6 | 63.2 | BLAST+: architecture and applications. | Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L Madden | BMC Bioinformatics | 2009 | 20003500 | Yes |
| 1147 | 2206 | 2206.0 | 55.6 | 55.6 | Mechanisms of hepatic fibrogenesis. | Scott L Friedman | Gastroenterology | 2008 | 18471545 | No |
| 1148 | 2205 | 2205.0 | 55.4 | 55.4 | Interfaces and the driving force of hydrophobic assembly. | David Chandler | Nature | 2005 | 16193038 | No |
| 1149 | 4410 | 2205.0 | 184.0 | 92.0 | The integrative review: updated methodology. | Robin Whittemore, Kathleen Knafl | J Adv Nurs | 2005 | 16268861 | Yes |
| 1150 | 2204 | 2204.0 | 69.7 | 69.7 | Prooxidant states and tumor promotion. | P A Cerutti | Science | 1985 | 2981433 | No |
| 1151 | 2204 | 2204.0 | 51.5 | 51.5 | Chemokines. | B J Rollins | Blood | 1997 | 9242519 | No |
| 1152 | 6612 | 2204.0 | 179.4 | 59.8 | Fast model-based estimation of ancestry in unrelated individuals. | David H Alexander, John Novembre, Kenneth Lange | Genome Res | 2009 | 19648217 | Yes |
| 1153 | 4407 | 2203.5 | 88.6 | 44.3 | Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. | Rudolf Jaenisch, Adrian Bird | Nat Genet | 2003 | 12610534 | No |
| 1154 | 4405 | 2202.5 | 146.8 | 73.4 | Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. | R B Devereux, N Reichek | Circulation | 1977 | 138494 | Yes |
| 1155 | 2202 | 2202.0 | 86.0 | 86.0 | Role of endothelium in responses of vascular smooth muscle. | R F Furchgott | Circ Res | 1983 | 6313250 | No |
| 1156 | 2202 | 2202.0 | 86.8 | 86.8 | α-band oscillations, attention, and controlled access to stored information. | Wolfgang Klimesch | Trends Cogn Sci | 2012 | 23141428 | No |
| 1157 | 4394 | 2197.0 | 108.8 | 54.4 | Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. | G G Glenner, C W Wong | Biochem Biophys Res Commun | 1984 | 6375662 | Yes |
| 1158 | 4392 | 2196.0 | 200.0 | 100.0 | Stages and processes of self-change of smoking: toward an integrative model of change. | J O Prochaska, C C DiClemente | J Consult Clin Psychol | 1983 | 6863699 | Yes |
| 1159 | 2193 | 2193.0 | 84.9 | 84.9 | Health consequences of intimate partner violence. | Jacquelyn C Campbell | Lancet | 2002 | 11965295 | No |
| 1160 | 6575 | 2191.7 | 225.3 | 75.1 | Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. | C Lord, M Rutter, A Le Couteur | J Autism Dev Disord | 1994 | 7814313 | Yes |
| 1161 | 2191 | 2191.0 | 71.4 | 71.4 | Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. | Sergio Pecorelli | Int J Gynaecol Obstet | 2009 | 19367689 | No |
| 1162 | 4379 | 2189.5 | 118.2 | 59.1 | Cutaneous wound healing. | A J Singer, R A Clark | N Engl J Med | 1999 | 10471461 | No |
| 1163 | 2189 | 2189.0 | 48.4 | 48.4 | Developmental regulation of the growth plate. | Henry M Kronenberg | Nature | 2003 | 12748651 | No |
| 1164 | 2189 | 2189.0 | 41.2 | 41.2 | NK cell recognition. | Lewis L Lanier | Annu Rev Immunol | 2005 | 15771571 | No |
| 1165 | 6559 | 2186.3 | 332.9 | 111.0 | Production, use, and fate of all plastics ever made. | Roland Geyer, Jenna R Jambeck, Kara Lavender Law | Sci Adv | 2017 | 28776036 | Yes |
| 1166 | 4370 | 2185.0 | 139.6 | 69.8 | Event-related EEG/MEG synchronization and desynchronization: basic principles. | G Pfurtscheller, F H Lopes Da Silva | Clin Neurophysiol | 1999 | 10576479 | No |
| 1167 | 4370 | 2185.0 | 240.9 | 120.5 | Interactive Tree Of Life (iTOL) v4: recent updates and new developments. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2019 | 30931475 | Yes |
| 1168 | 4367 | 2183.5 | 184.1 | 92.0 | The Oswestry Disability Index. | J C Fairbank, P B Pynsent | Spine (Phila Pa 1976) | 2000 | 11074683 | Yes |
| 1169 | 2182 | 2182.0 | 43.6 | 43.6 | Signalling pathways of the TNF superfamily: a double-edged sword. | Bharat B Aggarwal | Nat Rev Immunol | 2003 | 12949498 | No |
| 1170 | 2179 | 2179.0 | 0.0 | 0.0 | The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. | D E Atkinson | Biochemistry | 1968 | 4972613 | Yes |
| 1171 | 4358 | 2179.0 | 145.0 | 72.5 | Saliency, switching, attention and control: a network model of insula function. | Vinod Menon, Lucina Q Uddin | Brain Struct Funct | 2010 | 20512370 | No |
| 1172 | 8714 | 2178.5 | 347.2 | 86.8 | The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. | T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerstrom | Br J Addict | 1991 | 1932883 | Yes |
| 1173 | 6535 | 2178.3 | 124.2 | 41.4 | Control of regulatory T cell development by the transcription factor Foxp3. | Shohei Hori, Takashi Nomura, Shimon Sakaguchi | Science | 2003 | 12522256 | Yes |
| 1174 | 2178 | 2178.0 | 44.3 | 44.3 | DNA methylation and human disease. | Keith D Robertson | Nat Rev Genet | 2005 | 16136652 | No |
| 1175 | 2177 | 2177.0 | 46.4 | 46.4 | Role of angiogenesis in tumor growth and metastasis. | Judah Folkman | Semin Oncol | 2002 | 12516034 | No |
| 1176 | 4354 | 2177.0 | 110.9 | 55.5 | Regulation of chromatin by histone modifications. | Andrew J Bannister, Tony Kouzarides | Cell Res | 2011 | 21321607 | No |
| 1177 | 2175 | 2175.0 | 52.9 | 52.9 | The retinal pigment epithelium in visual function. | Olaf Strauss | Physiol Rev | 2005 | 15987797 | No |
| 1178 | 2173 | 2173.0 | 49.3 | 49.3 | Chemokines and leukocyte traffic. | M Baggiolini | Nature | 1998 | 9560152 | No |
| 1179 | 2173 | 2173.0 | 0.0 | 0.0 | On respiratory impairment in cancer cells. | O Warburg | Science | 1956 | 13351639 | Yes |
| 1180 | 4344 | 2172.0 | 0.0 | 0.0 | Genetic regulatory mechanisms in the synthesis of proteins. | F Jacob, J Monod | J Mol Biol | 1961 | 13718526 | Yes |
| 1181 | 2170 | 2170.0 | 45.7 | 45.7 | Metastasis to bone: causes, consequences and therapeutic opportunities. | Gregory R Mundy | Nat Rev Cancer | 2002 | 12154351 | No |
| 1182 | 2168 | 2168.0 | 0.0 | 0.0 | Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. | P Mitchell | Biol Rev Camb Philos Soc | 1966 | 5329743 | No |
| 1183 | 15175 | 2167.9 | 363.0 | 51.9 | Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. | Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman | Genome Biol | 2002 | 12184808 | Yes |
| 1184 | 4335 | 2167.5 | 287.3 | 143.7 | WHO Declares COVID-19 a Pandemic. | Domenico Cucinotta, Maurizio Vanelli | Acta Biomed | 2020 | 32191675 | Yes |
| 1185 | 2167 | 2167.0 | 42.5 | 42.5 | Protein modules and signalling networks. | T Pawson | Nature | 1995 | 7531822 | No |
| 1186 | 4334 | 2167.0 | 141.8 | 70.9 | Regulation of microRNA biogenesis. | Minju Ha, V Narry Kim | Nat Rev Mol Cell Biol | 2014 | 25027649 | No |
| 1187 | 2165 | 2165.0 | 58.6 | 58.6 | From sensation to cognition. | M M Mesulam | Brain | 1998 | 9648540 | No |
| 1188 | 2165 | 2165.0 | 46.5 | 46.5 | Molecular bases for circadian clocks. | J C Dunlap | Cell | 1999 | 9988221 | No |
| 1189 | 2164 | 2164.0 | 0.0 | 0.0 | Cognitive maps in rats and men. | E C Tolman | Psychol Rev | 1948 | 18870876 | Yes |
| 1190 | 4327 | 2163.5 | 173.7 | 86.8 | The need to belong: desire for interpersonal attachments as a fundamental human motivation. | R F Baumeister, M R Leary | Psychol Bull | 1995 | 7777651 | No |
| 1191 | 4323 | 2161.5 | 104.6 | 52.3 | Assembly of asparagine-linked oligosaccharides. | R Kornfeld, S Kornfeld | Annu Rev Biochem | 1985 | 3896128 | No |
| 1192 | 6482 | 2160.7 | 295.3 | 98.4 | Radiomics: Images Are More than Pictures, They Are Data. | Robert J Gillies, Paul E Kinahan, Hedvig Hricak | Radiology | 2016 | 26579733 | Yes |
| 1193 | 4316 | 2158.0 | 191.9 | 96.0 | The Brief Symptom Inventory: an introductory report. | L R Derogatis, N Melisaratos | Psychol Med | 1983 | 6622612 | Yes |
| 1194 | 4312 | 2156.0 | 131.8 | 65.9 | Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. | J S Beckman, W H Koppenol | Am J Physiol | 1996 | 8944624 | No |
| 1195 | 2156 | 2156.0 | 51.6 | 51.6 | Integration, scaling, space-group assignment and post-refinement. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124693 | Yes |
| 1196 | 2155 | 2155.0 | 103.9 | 103.9 | Performance-oriented assessment of mobility problems in elderly patients. | M E Tinetti | J Am Geriatr Soc | 1986 | 3944402 | Yes |
| 1197 | 2155 | 2155.0 | 49.1 | 49.1 | Neutrophils and immunity: challenges and opportunities. | Carl Nathan | Nat Rev Immunol | 2006 | 16498448 | No |
| 1198 | 2155 | 2155.0 | 85.6 | 85.6 | Periodontitis: from microbial immune subversion to systemic inflammation. | George Hajishengallis | Nat Rev Immunol | 2015 | 25534621 | No |
| 1199 | 8618 | 2154.5 | 356.7 | 89.2 | Guidelines for the process of cross-cultural adaptation of self-report measures. | D E Beaton, C Bombardier, F Guillemin, M B Ferraz | Spine (Phila Pa 1976) | 2000 | 11124735 | No |
| 1200 | 2153 | 2153.0 | 0.0 | 0.0 | Sedimentation Studies Of The Size And Shape Of Dna. | F W Studier | J Mol Biol | 1965 | 14290352 | Yes |
| 1201 | 6453 | 2151.0 | 216.7 | 72.2 | Parallel organization of functionally segregated circuits linking basal ganglia and cortex. | G E Alexander, M R DeLong, P L Strick | Annu Rev Neurosci | 1986 | 3085570 | No |
| 1202 | 4302 | 2151.0 | 0.0 | 0.0 | A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. | R F Beers, I W Sizer | J Biol Chem | 1952 | 14938361 | Yes |
| 1203 | 2149 | 2149.0 | 46.8 | 46.8 | TRP channels as cellular sensors. | David E Clapham | Nature | 2003 | 14654832 | No |
| 1204 | 6442 | 2147.3 | 152.3 | 50.8 | MOLMOL: a program for display and analysis of macromolecular structures. | R Koradi, M Billeter, K Wuthrich | J Mol Graph | 1996 | 8744573 | Yes |
| 1205 | 2147 | 2147.0 | 0.0 | 0.0 | A new specific color reaction of hexuronic acids. | Z Dische | J Biol Chem | 1947 | 20281638 | Yes |
| 1206 | 6440 | 2146.7 | 0.0 | 0.0 | Immunochemical quantitation of antigens by single radial immunodiffusion. | G Mancini, A O Carbonara, J F Heremans | Immunochemistry | 1965 | 4956917 | Yes |
| 1207 | 2146 | 2146.0 | 67.4 | 67.4 | The unbiased estimation of number and sizes of arbitrary particles using the disector. | D C Sterio | J Microsc | 1984 | 6737468 | Yes |
| 1208 | 4291 | 2145.5 | 113.8 | 56.9 | The heat-shock proteins. | S Lindquist, E A Craig | Annu Rev Genet | 1988 | 2853609 | No |
| 1209 | 4290 | 2145.0 | 0.0 | 0.0 | A Simplified Lead Citrate Stain For Use In Electron Microscopy. | J H Venable, R Coggeshall | J Cell Biol | 1965 | 14287192 | Yes |
| 1210 | 2144 | 2144.0 | 46.8 | 46.8 | The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. | Michael R Lieber | Annu Rev Biochem | 2010 | 20192759 | No |
| 1211 | 6430 | 2143.3 | 273.5 | 91.2 | Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. | B N Ames, J McCann, E Yamasaki | Mutat Res | 1975 | 768755 | Yes |
| 1212 | 17134 | 2141.8 | 444.9 | 55.6 | Electric field effect in atomically thin carbon films. | K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov | Science | 2004 | 15499015 | Yes |
| 1213 | 4280 | 2140.0 | 88.1 | 44.0 | A guided tour into subcellular colocalization analysis in light microscopy. | S Bolte, F P Cordelieres | J Microsc | 2006 | 17210054 | Yes |
| 1214 | 2136 | 2136.0 | 44.4 | 44.4 | DNA topoisomerases: structure, function, and mechanism. | J J Champoux | Annu Rev Biochem | 2001 | 11395412 | No |
| 1215 | 6403 | 2134.3 | 204.4 | 68.1 | SCANPY: large-scale single-cell gene expression data analysis. | F Alexander Wolf, Philipp Angerer, Fabian J Theis | Genome Biol | 2018 | 29409532 | Yes |
| 1216 | 2134 | 2134.0 | 64.5 | 64.5 | Cell biology and molecular basis of denitrification. | W G Zumft | Microbiol Mol Biol Rev | 1997 | 9409151 | No |
| 1217 | 4265 | 2132.5 | 110.8 | 55.4 | Function and activation of NF-kappa B in the immune system. | P A Baeuerle, T Henkel | Annu Rev Immunol | 1994 | 8011280 | No |
| 1218 | 4265 | 2132.5 | 86.1 | 43.0 | The Wnt signaling pathway in development and disease. | Catriona Y Logan, Roel Nusse | Annu Rev Cell Dev Biol | 2004 | 15473860 | No |
| 1219 | 2130 | 2130.0 | 93.3 | 93.3 | A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. | E L Bradley | Arch Surg | 1993 | 8489394 | No |
| 1220 | 4258 | 2129.0 | 89.5 | 44.8 | Mammalian MAP kinase signalling cascades. | L Chang, M Karin | Nature | 2001 | 11242034 | No |
| 1221 | 14901 | 2128.7 | 348.7 | 49.8 | Induction of pluripotent stem cells from adult human fibroblasts by defined factors. | Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka | Cell | 2007 | 18035408 | Yes |
| 1222 | 2127 | 2127.0 | 69.6 | 69.6 | Cytokines in inflammatory bowel disease. | Markus F Neurath | Nat Rev Immunol | 2014 | 24751956 | No |
| 1223 | 4253 | 2126.5 | 126.7 | 63.4 | Angiogenic factors. | J Folkman, M Klagsbrun | Science | 1987 | 2432664 | No |
| 1224 | 2126 | 2126.0 | 68.1 | 68.1 | Calculation of substrate oxidation rates in vivo from gaseous exchange. | K N Frayn | J Appl Physiol Respir Environ Exerc Physiol | 1983 | 6618956 | Yes |
| 1225 | 4249 | 2124.5 | 118.9 | 59.5 | Molecular mechanisms and clinical applications of angiogenesis. | Peter Carmeliet, Rakesh K Jain | Nature | 2011 | 21593862 | No |
| 1226 | 8497 | 2124.2 | 256.3 | 64.1 | Comorbidity measures for use with administrative data. | A Elixhauser, C Steiner, D R Harris, R M Coffey | Med Care | 1998 | 9431328 | Yes |
| 1227 | 2124 | 2124.0 | 45.4 | 45.4 | Mammalian G1 cyclins. | C J Sherr | Cell | 1993 | 8513492 | No |
| 1228 | 4246 | 2123.0 | 84.8 | 42.4 | Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. | M Gossen, H Bujard | Proc Natl Acad Sci U S A | 1992 | 1319065 | Yes |
| 1229 | 2123 | 2123.0 | 78.8 | 78.8 | The global burden of IBD: from 2015 to 2025. | Gilaad G Kaplan | Nat Rev Gastroenterol Hepatol | 2015 | 26323879 | No |
| 1230 | 16982 | 2122.8 | 599.0 | 74.9 | GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. | Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schunemann, | BMJ | 2008 | 18436948 | Yes |
| 1231 | 2121 | 2121.0 | 0.0 | 0.0 | Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. | D Aminoff | Biochem J | 1961 | 13860975 | Yes |
| 1232 | 12725 | 2120.8 | 313.7 | 52.3 | GROMACS: fast, flexible, and free. | David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen | J Comput Chem | 2005 | 16211538 | Yes |
| 1233 | 8478 | 2119.5 | 0.0 | 0.0 | Antibiotic susceptibility testing by a standardized single disk method. | A W Bauer, W M Kirby, J C Sherris, M Turck | Am J Clin Pathol | 1966 | 5325707 | Yes |
| 1234 | 2119 | 2119.0 | 67.8 | 67.8 | Multiple imputation: a primer. | J L Schafer | Stat Methods Med Res | 1999 | 10347857 | No |
| 1235 | 2119 | 2119.0 | 50.9 | 50.9 | DAMPs, PAMPs and alarmins: all we need to know about danger. | Marco E Bianchi | J Leukoc Biol | 2007 | 17032697 | No |
| 1236 | 2119 | 2119.0 | 122.3 | 122.3 | A network theory of mental disorders. | Denny Borsboom | World Psychiatry | 2017 | 28127906 | Yes |
| 1237 | 2118 | 2118.0 | 50.5 | 50.5 | Patterns of amino acids near signal-sequence cleavage sites. | G Von Heijne | Eur J Biochem | 1983 | 6852022 | Yes |
| 1238 | 4235 | 2117.5 | 94.0 | 47.0 | Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. | F Sallusto, A Lanzavecchia | J Exp Med | 1994 | 8145033 | Yes |
| 1239 | 2117 | 2117.0 | 58.1 | 58.1 | Hydrogels for biomedical applications. | Allan S Hoffman | Adv Drug Deliv Rev | 2002 | 11755703 | No |
| 1240 | 4231 | 2115.5 | 105.6 | 52.8 | Decision curve analysis: a novel method for evaluating prediction models. | Andrew J Vickers, Elena B Elkin | Med Decis Making | 2006 | 17099194 | Yes |
| 1241 | 2115 | 2115.0 | 78.2 | 78.2 | Determination of glutathione and glutathione disulfide in biological samples. | M E Anderson | Methods Enzymol | 1985 | 4088074 | Yes |
| 1242 | 4230 | 2115.0 | 183.9 | 92.0 | Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. | A Y Finlay, G K Khan | Clin Exp Dermatol | 1994 | 8033378 | Yes |
| 1243 | 2115 | 2115.0 | 58.7 | 58.7 | Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. | Ralph A Defronzo | Diabetes | 2009 | 19336687 | No |
| 1244 | 2115 | 2115.0 | 50.5 | 50.5 | The genetics of ageing. | Cynthia J Kenyon | Nature | 2010 | 20336132 | No |
| 1245 | 2113 | 2113.0 | 0.0 | 0.0 | The plasma lecithins:cholesterol acyltransferase reaction. | J A Glomset | J Lipid Res | 1968 | 4868699 | No |
| 1246 | 10564 | 2112.8 | 482.2 | 96.4 | Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. | Daehwan Kim, Joseph M Paggi, Chanhee Park, Christopher Bennett, Steven L Salzberg | Nat Biotechnol | 2019 | 31375807 | Yes |
| 1247 | 4224 | 2112.0 | 105.4 | 52.7 | Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. | M Nei, T Gojobori | Mol Biol Evol | 1986 | 3444411 | Yes |
| 1248 | 6334 | 2111.3 | 202.2 | 67.4 | Arlequin (version 3.0): an integrated software package for population genetics data analysis. | Laurent Excoffier, Guillaume Laval, Stefan Schneider | Evol Bioinform Online | 2007 | 19325852 | Yes |
| 1249 | 4222 | 2111.0 | 98.9 | 49.5 | Parkinson's disease: mechanisms and models. | William Dauer, Serge Przedborski | Neuron | 2003 | 12971891 | No |
| 1250 | 2111 | 2111.0 | 41.7 | 41.7 | Notch signalling: a simple pathway becomes complex. | Sarah J Bray | Nat Rev Mol Cell Biol | 2006 | 16921404 | No |
| 1251 | 2111 | 2111.0 | 58.5 | 58.5 | What we can do and what we cannot do with fMRI. | Nikos K Logothetis | Nature | 2008 | 18548064 | No |
| 1252 | 4221 | 2110.5 | 111.9 | 56.0 | ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. | Markus Wiederstein, Manfred J Sippl | Nucleic Acids Res | 2007 | 17517781 | Yes |
| 1253 | 4220 | 2110.0 | 111.9 | 56.0 | Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. | E Lander, L Kruglyak | Nat Genet | 1995 | 7581446 | Yes |
| 1254 | 4220 | 2110.0 | 134.6 | 67.3 | Neutrophil recruitment and function in health and inflammation. | Elzbieta Kolaczkowska, Paul Kubes | Nat Rev Immunol | 2013 | 23435331 | No |
| 1255 | 4218 | 2109.0 | 146.4 | 73.2 | The benefits of being present: mindfulness and its role in psychological well-being. | Kirk Warren Brown, Richard M Ryan | J Pers Soc Psychol | 2003 | 12703651 | Yes |
| 1256 | 8425 | 2106.2 | 249.3 | 62.3 | Image quality assessment: from error visibility to structural similarity. | Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P Simoncelli | IEEE Trans Image Process | 2004 | 15376593 | Yes |
| 1257 | 6317 | 2105.7 | 216.2 | 72.1 | AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. | P G Reeves, F H Nielsen, G C Fahey | J Nutr | 1993 | 8229312 | No |
| 1258 | 2105 | 2105.0 | 55.6 | 55.6 | Negative refraction makes a perfect lens | J B Pendry | Phys Rev Lett | 2000 | 11041972 | Yes |
| 1259 | 2104 | 2104.0 | 74.8 | 74.8 | Epidemiological features of chronic low-back pain. | G B Andersson | Lancet | 1999 | 10470716 | No |
| 1260 | 2103 | 2103.0 | 62.2 | 62.2 | Estimating causal effects from large data sets using propensity scores. | D B Rubin | Ann Intern Med | 1997 | 9382394 | No |
| 1261 | 2102 | 2102.0 | 89.2 | 89.2 | The drug abuse screening test. | H A Skinner | Addict Behav | 1982 | 7183189 | Yes |
| 1262 | 2101 | 2101.0 | 59.8 | 59.8 | The inverse care law. | J T Hart | Lancet | 1971 | 4100731 | Yes |
| 1263 | 2101 | 2101.0 | 43.2 | 43.2 | Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. | Shimon Sakaguchi | Nat Immunol | 2005 | 15785760 | No |
| 1264 | 2101 | 2101.0 | 59.9 | 59.9 | The origins of the developmental origins theory. | D J P Barker | J Intern Med | 2007 | 17444880 | No |
| 1265 | 4201 | 2100.5 | 86.4 | 43.2 | An automated method for finding molecular complexes in large protein interaction networks. | Gary D Bader, Christopher W V Hogue | BMC Bioinformatics | 2003 | 12525261 | Yes |
| 1266 | 2097 | 2097.0 | 73.6 | 73.6 | Social relationships and health. | Sheldon Cohen | Am Psychol | 2004 | 15554821 | No |
| 1267 | 2096 | 2096.0 | 41.3 | 41.3 | Approaching the asymptote? Evolution and revolution in immunology. | C A Janeway | Cold Spring Harb Symp Quant Biol | 1989 | 2700931 | No |
| 1268 | 4191 | 2095.5 | 147.6 | 73.8 | Understanding interobserver agreement: the kappa statistic. | Anthony J Viera, Joanne M Garrett | Fam Med | 2005 | 15883903 | Yes |
| 1269 | 4191 | 2095.5 | 158.3 | 79.2 | Alginate: properties and biomedical applications. | Kuen Yong Lee, David J Mooney | Prog Polym Sci | 2012 | 22125349 | Yes |
| 1270 | 2095 | 2095.0 | 55.1 | 55.1 | Flow-mediated endothelial mechanotransduction. | P F Davies | Physiol Rev | 1995 | 7624393 | No |
| 1271 | 4189 | 2094.5 | 122.2 | 61.1 | The pathogenesis of rheumatoid arthritis. | Iain B McInnes, Georg Schett | N Engl J Med | 2011 | 22150039 | No |
| 1272 | 2094 | 2094.0 | 42.8 | 42.8 | Antiviral actions of interferons. | C E Samuel | Clin Microbiol Rev | 2001 | 11585785 | No |
| 1273 | 2094 | 2094.0 | 55.9 | 55.9 | Molecular dissection of reactive astrogliosis and glial scar formation. | Michael V Sofroniew | Trends Neurosci | 2009 | 19782411 | No |
| 1274 | 4187 | 2093.5 | 164.6 | 82.3 | The transtheoretical model of health behavior change. | J O Prochaska, W F Velicer | Am J Health Promot | 1997 | 10170434 | No |
| 1275 | 2093 | 2093.0 | 56.9 | 56.9 | The heme oxygenase system: a regulator of second messenger gases. | M D Maines | Annu Rev Pharmacol Toxicol | 1997 | 9131263 | No |
| 1276 | 2093 | 2093.0 | 0.0 | 0.0 | Method For Assay Of Intestinal Disaccharidases. | A Dahlqvist | Anal Biochem | 1964 | 14106916 | Yes |
| 1277 | 2091 | 2091.0 | 52.2 | 52.2 | Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. | B L Wajchenberg | Endocr Rev | 2000 | 11133069 | No |
| 1278 | 4180 | 2090.0 | 122.1 | 61.0 | Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. | M A Nitsche, W Paulus | J Physiol | 2000 | 10990547 | Yes |
| 1279 | 2088 | 2088.0 | 103.8 | 103.8 | DLS and zeta potential - What they are and what they are not? | Sourav Bhattacharjee | J Control Release | 2016 | 27297779 | No |
| 1280 | 2087 | 2087.0 | 50.1 | 50.1 | Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. | G Trinchieri | Annu Rev Immunol | 1995 | 7612223 | No |
| 1281 | 2086 | 2086.0 | 61.1 | 61.1 | ATP-regulated K+ channels in cardiac muscle. | A Noma | Nature | 1983 | 6310409 | Yes |
| 1282 | 4169 | 2084.5 | 115.4 | 57.7 | New perspectives in cell adhesion: RGD and integrins. | E Ruoslahti, M D Pierschbacher | Science | 1987 | 2821619 | No |
| 1283 | 2084 | 2084.0 | 62.5 | 62.5 | Introduction and General Overview of Cyclodextrin Chemistry. | Jozsef Szejtli | Chem Rev | 1998 | 11848947 | Yes |
| 1284 | 4165 | 2082.5 | 139.4 | 69.7 | Elements of cancer immunity and the cancer-immune set point. | Daniel S Chen, Ira Mellman | Nature | 2017 | 28102259 | No |
| 1285 | 6246 | 2082.0 | 253.2 | 84.4 | Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. | G Muyzer, E C De Waal, A G Uitterlinden | Appl Environ Microbiol | 1993 | 7683183 | Yes |
| 1286 | 2081 | 2081.0 | 86.9 | 86.9 | Oxidative stress: a concept in redox biology and medicine. | Helmut Sies | Redox Biol | 2015 | 25588755 | No |
| 1287 | 2081 | 2081.0 | 143.1 | 143.1 | The changing landscape of atherosclerosis. | Peter Libby | Nature | 2021 | 33883728 | No |
| 1288 | 2080 | 2080.0 | 66.1 | 66.1 | Sick individuals and sick populations. | G Rose | Int J Epidemiol | 1985 | 3872850 | Yes |
| 1289 | 4154 | 2077.0 | 100.3 | 50.1 | Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. | B A Reynolds, S Weiss | Science | 1992 | 1553558 | Yes |
| 1290 | 2077 | 2077.0 | 91.0 | 91.0 | A rating scale for drug-induced akathisia. | T R Barnes | Br J Psychiatry | 1989 | 2574607 | Yes |
| 1291 | 2077 | 2077.0 | 0.0 | 0.0 | Dendritic organization in the neurons of the visual and motor cortices of the cat. | D A Sholl | J Anat | 1953 | 13117757 | Yes |
| 1292 | 4154 | 2077.0 | 112.5 | 56.2 | Protective and pathogenic functions of macrophage subsets. | Peter J Murray, Thomas A Wynn | Nat Rev Immunol | 2011 | 21997792 | No |
| 1293 | 4152 | 2076.0 | 112.0 | 56.0 | Mathematical model for studying genetic variation in terms of restriction endonucleases. | M Nei, W H Li | Proc Natl Acad Sci U S A | 1979 | 291943 | Yes |
| 1294 | 2075 | 2075.0 | 36.5 | 36.5 | Mechanisms of alternative pre-messenger RNA splicing. | Douglas L Black | Annu Rev Biochem | 2003 | 12626338 | No |
| 1295 | 6225 | 2075.0 | 196.2 | 65.4 | Simultaneous inference in general parametric models. | Torsten Hothorn, Frank Bretz, Peter Westfall | Biom J | 2008 | 18481363 | No |
| 1296 | 2074 | 2074.0 | 71.0 | 71.0 | The use of a plus-maze to measure anxiety in the mouse. | R G Lister | Psychopharmacology (Berl) | 1987 | 3110839 | Yes |
| 1297 | 4147 | 2073.5 | 99.7 | 49.9 | Macrophage diversity enhances tumor progression and metastasis. | Bin-Zhi Qian, Jeffrey W Pollard | Cell | 2010 | 20371344 | No |
| 1298 | 2073 | 2073.0 | 36.3 | 36.3 | ATM and related protein kinases: safeguarding genome integrity. | Yosef Shiloh | Nat Rev Cancer | 2003 | 12612651 | No |
| 1299 | 2073 | 2073.0 | 0.0 | 0.0 | Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. | J C Skou | Physiol Rev | 1965 | 14337569 | No |
| 1300 | 2073 | 2073.0 | 59.0 | 59.0 | Understanding organofluorine chemistry. An introduction to the C-F bond. | David O'Hagan | Chem Soc Rev | 2008 | 18197347 | No |
| 1301 | 2072 | 2072.0 | 61.1 | 61.1 | Inhibited spontaneous emission in solid-state physics and electronics. | E Yablonovitch | Phys Rev Lett | 1987 | 10034639 | Yes |
| 1302 | 2071 | 2071.0 | 41.5 | 41.5 | Systems biology: a brief overview. | Hiroaki Kitano | Science | 2002 | 11872829 | No |
| 1303 | 6212 | 2070.7 | 435.3 | 145.1 | Ferroptosis: mechanisms, biology and role in disease. | Xuejun Jiang, Brent R Stockwell, Marcus Conrad | Nat Rev Mol Cell Biol | 2021 | 33495651 | No |
| 1304 | 2070 | 2070.0 | 57.6 | 57.6 | Dengue and dengue hemorrhagic fever. | D J Gubler | Clin Microbiol Rev | 1998 | 9665979 | No |
| 1305 | 2069 | 2069.0 | 43.3 | 43.3 | G1 events and regulation of cell proliferation. | A B Pardee | Science | 1989 | 2683075 | No |
| 1306 | 4135 | 2067.5 | 111.1 | 55.5 | Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering | S Nie, S R Emory | Science | 1997 | 9027306 | Yes |
| 1307 | 6202 | 2067.3 | 133.4 | 44.5 | Adjusting batch effects in microarray expression data using empirical Bayes methods. | W Evan Johnson, Cheng Li, Ariel Rabinovic | Biostatistics | 2007 | 16632515 | Yes |
| 1308 | 4134 | 2067.0 | 115.7 | 57.9 | Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. | B J Marshall, J R Warren | Lancet | 1984 | 6145023 | Yes |
| 1309 | 2066 | 2066.0 | 0.0 | 0.0 | Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? | J V Neel | Am J Hum Genet | 1962 | 13937884 | Yes |
| 1310 | 2065 | 2065.0 | 81.0 | 81.0 | Predicting basal metabolic rate, new standards and review of previous work. | W N Schofield | Hum Nutr Clin Nutr | 1985 | 4044297 | Yes |
| 1311 | 12390 | 2065.0 | 379.6 | 63.3 | New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. | Stephane Guindon, Jean-Francois Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel | Syst Biol | 2010 | 20525638 | Yes |
| 1312 | 4129 | 2064.5 | 0.0 | 0.0 | Plaque formation and isolation of pure lines with poliomyelitis viruses. | R Dulbecco, M Vogt | J Exp Med | 1954 | 13130792 | Yes |
| 1313 | 2064 | 2064.0 | 0.0 | 0.0 | The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. | W W Cleland | Biochim Biophys Acta | 1963 | 14021667 | Yes |
| 1314 | 18574 | 2063.8 | 615.4 | 68.4 | The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. | , D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert | N Engl J Med | 1993 | 8366922 | Yes |
| 1315 | 2063 | 2063.0 | 60.4 | 60.4 | Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. | Robert E Marx | J Oral Maxillofac Surg | 2003 | 12966493 | Yes |
| 1316 | 2063 | 2063.0 | 61.2 | 61.2 | Apoptosis in cancer: from pathogenesis to treatment. | Rebecca S Y Wong | J Exp Clin Cancer Res | 2011 | 21943236 | No |
| 1317 | 2060 | 2060.0 | 60.7 | 60.7 | Synergy, antagonism, and what the chequerboard puts between them. | F C Odds | J Antimicrob Chemother | 2003 | 12805255 | No |
| 1318 | 4119 | 2059.5 | 101.1 | 50.5 | The acute respiratory distress syndrome. | L B Ware, M A Matthay | N Engl J Med | 2000 | 10793167 | No |
| 1319 | 4115 | 2057.5 | 153.1 | 76.5 | Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. | Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon | Brain Connect | 2012 | 22642651 | Yes |
| 1320 | 26740 | 2056.9 | 1049.3 | 80.7 | Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. | Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L Rehm, | Genet Med | 2015 | 25741868 | Yes |
| 1321 | 4113 | 2056.5 | 89.2 | 44.6 | A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. | G Shaw, R Kamen | Cell | 1986 | 3488815 | Yes |
| 1322 | 2056 | 2056.0 | 63.5 | 63.5 | Stress signalling pathways that impair prefrontal cortex structure and function. | Amy F T Arnsten | Nat Rev Neurosci | 2009 | 19455173 | No |
| 1323 | 8219 | 2054.8 | 203.5 | 50.9 | Epithelial-mesenchymal transitions in development and disease. | Jean Paul Thiery, Herve Acloque, Ruby Y J Huang, M Angela Nieto | Cell | 2009 | 19945376 | No |
| 1324 | 2054 | 2054.0 | 46.0 | 46.0 | A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. | J SantaLucia | Proc Natl Acad Sci U S A | 1998 | 9465037 | Yes |
| 1325 | 2053 | 2053.0 | 72.9 | 72.9 | The polyvagal perspective. | Stephen W Porges | Biol Psychol | 2007 | 17049418 | No |
| 1326 | 2052 | 2052.0 | 62.4 | 62.4 | Protein oxidation and aging. | E R Stadtman | Science | 1992 | 1355616 | No |
| 1327 | 2051 | 2051.0 | 56.6 | 56.6 | Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. | B Winkel-Shirley | Plant Physiol | 2001 | 11402179 | No |
| 1328 | 4102 | 2051.0 | 122.8 | 61.4 | The precuneus: a review of its functional anatomy and behavioural correlates. | Andrea E Cavanna, Michael R Trimble | Brain | 2006 | 16399806 | No |
| 1329 | 2051 | 2051.0 | 64.1 | 64.1 | Stress and disorders of the stress system. | George P Chrousos | Nat Rev Endocrinol | 2009 | 19488073 | No |
| 1330 | 2050 | 2050.0 | 0.0 | 0.0 | Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. | J W Littlefield | Science | 1964 | 14168277 | Yes |
| 1331 | 4095 | 2047.5 | 123.6 | 61.8 | A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. | J A Horne, O Ostberg | Int J Chronobiol | 1976 | 1027738 | Yes |
| 1332 | 2047 | 2047.0 | 41.4 | 41.4 | The complex language of chromatin regulation during transcription. | Shelley L Berger | Nature | 2007 | 17522673 | No |
| 1333 | 12274 | 2045.7 | 395.6 | 65.9 | Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939837 | Yes |
| 1334 | 4090 | 2045.0 | 99.2 | 49.6 | Base-calling of automated sequencer traces using phred. II. Error probabilities. | B Ewing, P Green | Genome Res | 1998 | 9521922 | Yes |
| 1335 | 2045 | 2045.0 | 59.4 | 59.4 | The comet assay for DNA damage and repair: principles, applications, and limitations. | Andrew R Collins | Mol Biotechnol | 2004 | 15004294 | No |
| 1336 | 2042 | 2042.0 | 220.7 | 220.7 | Epidemiology of chronic kidney disease: an update 2022. | Csaba P Kovesdy | Kidney Int Suppl (2011) | 2022 | 35529086 | No |
| 1337 | 2039 | 2039.0 | 89.1 | 89.1 | Sample size in qualitative research. | M Sandelowski | Res Nurs Health | 1995 | 7899572 | Yes |
| 1338 | 4076 | 2038.0 | 118.3 | 59.1 | CTFFIND4: Fast and accurate defocus estimation from electron micrographs. | Alexis Rohou, Nikolaus Grigorieff | J Struct Biol | 2015 | 26278980 | Yes |
| 1339 | 2037 | 2037.0 | 48.1 | 48.1 | Interleukin-2: inception, impact, and implications. | K A Smith | Science | 1988 | 3131876 | No |
| 1340 | 2037 | 2037.0 | 62.6 | 62.6 | The role of senescent cells in ageing. | Jan M Van Deursen | Nature | 2014 | 24848057 | No |
| 1341 | 2036 | 2036.0 | 43.4 | 43.4 | Mechanisms of cancer drug resistance. | Michael M Gottesman | Annu Rev Med | 2002 | 11818492 | No |
| 1342 | 2036 | 2036.0 | 46.9 | 46.9 | Targeting PI3K signalling in cancer: opportunities, challenges and limitations. | Jeffrey A Engelman | Nat Rev Cancer | 2009 | 19629070 | No |
| 1343 | 2035 | 2035.0 | 49.5 | 49.5 | Calcium signaling. | D E Clapham | Cell | 1995 | 7834745 | No |
| 1344 | 4068 | 2034.0 | 126.7 | 63.4 | New method for quantitative determination of uronic acids. | N Blumenkrantz, G Asboe-Hansen | Anal Biochem | 1973 | 4269305 | Yes |
| 1345 | 2034 | 2034.0 | 70.4 | 70.4 | Validation of a decisional conflict scale. | A M O'Connor | Med Decis Making | 1995 | 7898294 | Yes |
| 1346 | 2033 | 2033.0 | 63.5 | 63.5 | The atom economy--a search for synthetic efficiency. | B M Trost | Science | 1991 | 1962206 | Yes |
| 1347 | 2032 | 2032.0 | 73.9 | 73.9 | A modified card sorting test sensitive to frontal lobe defects. | H E Nelson | Cortex | 1976 | 1009768 | Yes |
| 1348 | 2032 | 2032.0 | 37.9 | 37.9 | In situ hybridization: an improved whole-mount method for Xenopus embryos. | R M Harland | Methods Cell Biol | 1991 | 1811161 | Yes |
| 1349 | 4063 | 2031.5 | 106.5 | 53.2 | Leptin and the regulation of body weight in mammals. | J M Friedman, J L Halaas | Nature | 1998 | 9796811 | No |
| 1350 | 2031 | 2031.0 | 49.6 | 49.6 | The global health burden of infection-associated cancers in the year 2002. | Donald Maxwell Parkin | Int J Cancer | 2006 | 16404738 | Yes |
| 1351 | 2031 | 2031.0 | 112.2 | 112.2 | Information bias in health research: definition, pitfalls, and adjustment methods. | Alaa Althubaiti | J Multidiscip Healthc | 2016 | 27217764 | No |
| 1352 | 4061 | 2030.5 | 101.9 | 51.0 | Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. | P Liang, A B Pardee | Science | 1992 | 1354393 | Yes |
| 1353 | 2030 | 2030.0 | 53.0 | 53.0 | Determination and analysis of urea and guanidine hydrochloride denaturation curves. | C N Pace | Methods Enzymol | 1986 | 3773761 | Yes |
| 1354 | 4060 | 2030.0 | 130.1 | 65.0 | Efficient pseudopotentials for plane-wave calculations. | N Troullier, J L Martins | Phys Rev B Condens Matter | 1991 | 9997467 | Yes |
| 1355 | 4057 | 2028.5 | 84.7 | 42.4 | A general framework for weighted gene co-expression network analysis. | Bin Zhang, Steve Horvath | Stat Appl Genet Mol Biol | 2005 | 16646834 | Yes |
| 1356 | 2028 | 2028.0 | 53.4 | 53.4 | Purinergic nerves. | G Burnstock | Pharmacol Rev | 1972 | 4404211 | No |
| 1357 | 10137 | 2027.4 | 246.4 | 49.3 | Mapping and quantifying mammalian transcriptomes by RNA-Seq. | Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold | Nat Methods | 2008 | 18516045 | Yes |
| 1358 | 2026 | 2026.0 | 57.8 | 57.8 | Analysis of bacteriophage T7 early RNAs and proteins on slab gels. | F W Studier | J Mol Biol | 1973 | 4760132 | Yes |
| 1359 | 2026 | 2026.0 | 0.0 | 0.0 | A theory of cerebellar cortex. | D Marr | J Physiol | 1969 | 5784296 | Yes |
| 1360 | 2024 | 2024.0 | 64.3 | 64.3 | Ethical authorship and publishing. | Andrew J S Coats | Int J Cardiol | 2009 | 19046787 | No |
| 1361 | 4045 | 2022.5 | 238.1 | 119.0 | An Overview of Heart Rate Variability Metrics and Norms. | Fred Shaffer, J P Ginsberg | Front Public Health | 2017 | 29034226 | No |
| 1362 | 2022 | 2022.0 | 45.5 | 45.5 | The immunopathogenesis of sepsis. | Jonathan Cohen | Nature | 2002 | 12490963 | No |
| 1363 | 8084 | 2021.0 | 325.6 | 81.4 | A simple technique for quantitation of low levels of DNA damage in individual cells. | N P Singh, M T McCoy, R R Tice, E L Schneider | Exp Cell Res | 1988 | 3345800 | Yes |
| 1364 | 4042 | 2021.0 | 88.5 | 44.2 | Lessons from hereditary colorectal cancer. | K W Kinzler, B Vogelstein | Cell | 1996 | 8861899 | No |
| 1365 | 2020 | 2020.0 | 64.2 | 64.2 | Chlorophyll fluorescence: a probe of photosynthesis in vivo. | Neil R Baker | Annu Rev Plant Biol | 2008 | 18444897 | No |
| 1366 | 2019 | 2019.0 | 40.9 | 40.9 | CpG motifs in bacterial DNA and their immune effects. | Arthur M Krieg | Annu Rev Immunol | 2002 | 11861616 | No |
| 1367 | 2019 | 2019.0 | 51.4 | 51.4 | Growth of the plant cell wall. | Daniel J Cosgrove | Nat Rev Mol Cell Biol | 2005 | 16261190 | No |
| 1368 | 4037 | 2018.5 | 119.4 | 59.7 | How good are my data and what is the resolution? | Philip R Evans, Garib N Murshudov | Acta Crystallogr D Biol Crystallogr | 2013 | 23793146 | Yes |
| 1369 | 8070 | 2017.5 | 317.1 | 79.3 | QUAST: quality assessment tool for genome assemblies. | Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn Tesler | Bioinformatics | 2013 | 23422339 | Yes |
| 1370 | 4033 | 2016.5 | 99.2 | 49.6 | PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. | Alexander W Schuttelkopf, Daan M F Van Aalten | Acta Crystallogr D Biol Crystallogr | 2004 | 15272157 | Yes |
| 1371 | 2016 | 2016.0 | 46.2 | 46.2 | Exploring complex networks. | S H Strogatz | Nature | 2001 | 11258382 | No |
| 1372 | 4030 | 2015.0 | 91.7 | 45.9 | Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. | J G Rheinwald, H Green | Cell | 1975 | 1052771 | Yes |
| 1373 | 2015 | 2015.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. | O Ouchterlony | Acta Pathol Microbiol Scand | 1949 | 18143039 | Yes |
| 1374 | 4028 | 2014.0 | 91.2 | 45.6 | Amino acid substitution matrices from protein blocks. | S Henikoff, J G Henikoff | Proc Natl Acad Sci U S A | 1992 | 1438297 | Yes |
| 1375 | 2014 | 2014.0 | 0.0 | 0.0 | Positional information and the spatial pattern of cellular differentiation. | L Wolpert | J Theor Biol | 1969 | 4390734 | Yes |
| 1376 | 2014 | 2014.0 | 37.0 | 37.0 | Signaling--2000 and beyond. | T Hunter | Cell | 2000 | 10647936 | No |
| 1377 | 4020 | 2010.0 | 89.7 | 44.9 | The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. | A J Ridley, A Hall | Cell | 1992 | 1643657 | Yes |
| 1378 | 4017 | 2008.5 | 407.9 | 203.9 | Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. | Luke A McGuinness, Julian P T Higgins | Res Synth Methods | 2021 | 32336025 | Yes |
| 1379 | 2008 | 2008.0 | 44.0 | 44.0 | XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. | D E McRee | J Struct Biol | 1999 | 10222271 | Yes |
| 1380 | 2007 | 2007.0 | 44.6 | 44.6 | Structural design and molecular evolution of a cytokine receptor superfamily. | J F Bazan | Proc Natl Acad Sci U S A | 1990 | 2169613 | Yes |
| 1381 | 4014 | 2007.0 | 115.1 | 57.5 | Insulin-like growth factors and their binding proteins: biological actions. | J I Jones, D R Clemmons | Endocr Rev | 1995 | 7758431 | No |
| 1382 | 2006 | 2006.0 | 48.8 | 48.8 | The blood-brain barrier: bottleneck in brain drug development. | William M Pardridge | NeuroRx | 2005 | 15717053 | No |
| 1383 | 8021 | 2005.2 | 346.7 | 86.7 | An inventory for measuring clinical anxiety: psychometric properties. | A T Beck, N Epstein, G Brown, R A Steer | J Consult Clin Psychol | 1988 | 3204199 | Yes |
| 1384 | 2005 | 2005.0 | 57.3 | 57.3 | The biology of interleukin-6. | T Kishimoto | Blood | 1989 | 2473791 | No |
| 1385 | 4009 | 2004.5 | 93.2 | 46.6 | Shared principles in NF-kappaB signaling. | Matthew S Hayden, Sankar Ghosh | Cell | 2008 | 18267068 | No |
| 1386 | 2003 | 2003.0 | 0.0 | 0.0 | The etiology of chondromalacia patellae. | R E Outerbridge | J Bone Joint Surg Br | 1961 | 14038135 | Yes |
| 1387 | 2003 | 2003.0 | 76.0 | 76.0 | Falls in older people: epidemiology, risk factors and strategies for prevention. | Laurence Z Rubenstein | Age Ageing | 2006 | 16926202 | No |
| 1388 | 2002 | 2002.0 | 75.5 | 75.5 | Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. | D R Janero | Free Radic Biol Med | 1990 | 2079232 | No |
| 1389 | 2001 | 2001.0 | 59.8 | 59.8 | The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. | G P Chrousos | N Engl J Med | 1995 | 7715646 | No |
| 1390 | 8004 | 2001.0 | 263.7 | 65.9 | cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination. | Ali Punjani, John L Rubinstein, David J Fleet, Marcus A Brubaker | Nat Methods | 2017 | 28165473 | Yes |
| 1391 | 2000 | 2000.0 | 0.0 | 0.0 | High-speed scanning in human memory. | S Sternberg | Science | 1966 | 5939936 | Yes |
| 1392 | 2000 | 2000.0 | 0.0 | 0.0 | Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. | M Kunitz | J Gen Physiol | 1947 | 19873496 | Yes |
| 1393 | 1999 | 1999.0 | 41.4 | 41.4 | Mechanisms of intracellular protein transport. | J E Rothman | Nature | 1994 | 7969419 | No |
| 1394 | 1999 | 1999.0 | 78.1 | 78.1 | The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. | E J Khantzian | Harv Rev Psychiatry | 1997 | 9385000 | No |
| 1395 | 1999 | 1999.0 | 43.8 | 43.8 | Thrombin signalling and protease-activated receptors. | S R Coughlin | Nature | 2000 | 11001069 | No |
| 1396 | 3998 | 1999.0 | 100.4 | 50.2 | The incidence of congenital heart disease. | Julien I E Hoffman, Samuel Kaplan | J Am Coll Cardiol | 2002 | 12084585 | No |
| 1397 | 5992 | 1997.3 | 157.2 | 52.4 | Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. | G S Hotamisligil, N S Shargill, B M Spiegelman | Science | 1993 | 7678183 | Yes |
| 1398 | 3994 | 1997.0 | 145.1 | 72.5 | Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. | M H Zweig, G Campbell | Clin Chem | 1993 | 8472349 | No |
| 1399 | 5988 | 1996.0 | 195.0 | 65.0 | Validation of the Insomnia Severity Index as an outcome measure for insomnia research. | C H Bastien, A Vallieres, C M Morin | Sleep Med | 2001 | 11438246 | Yes |
| 1400 | 1995 | 1995.0 | 56.0 | 56.0 | Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. | J Folkman | N Engl J Med | 1995 | 7491141 | No |
| 1401 | 5985 | 1995.0 | 112.0 | 37.3 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. | Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky | Nat Immunol | 2003 | 12612578 | Yes |
| 1402 | 1994 | 1994.0 | 0.0 | 0.0 | The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. | U E Loening | Biochem J | 1967 | 5339944 | Yes |
| 1403 | 3988 | 1994.0 | 0.0 | 0.0 | Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. | W R Morrison, L M Smith | J Lipid Res | 1964 | 14221106 | Yes |
| 1404 | 3988 | 1994.0 | 113.2 | 56.6 | Astrocytes: biology and pathology. | Michael V Sofroniew, Harry V Vinters | Acta Neuropathol | 2010 | 20012068 | No |
| 1405 | 5982 | 1994.0 | 343.0 | 114.3 | An interactive web-based dashboard to track COVID-19 in real time. | Ensheng Dong, Hongru Du, Lauren Gardner | Lancet Infect Dis | 2020 | 32087114 | Yes |
| 1406 | 3987 | 1993.5 | 118.4 | 59.2 | Variations in the pattern of pubertal changes in boys. | W A Marshall, J M Tanner | Arch Dis Child | 1970 | 5440182 | Yes |
| 1407 | 1993 | 1993.0 | 42.7 | 42.7 | The expanding role of mitochondria in apoptosis. | X Wang | Genes Dev | 2001 | 11711427 | No |
| 1408 | 1993 | 1993.0 | 73.5 | 73.5 | Guided Search 2.0 A revised model of visual search. | J M Wolfe | Psychon Bull Rev | 1994 | 24203471 | Yes |
| 1409 | 1992 | 1992.0 | 64.7 | 64.7 | Perceptual symbol systems. | L W Barsalou | Behav Brain Sci | 1999 | 11301525 | No |
| 1410 | 3983 | 1991.5 | 106.3 | 53.1 | The endophenotype concept in psychiatry: etymology and strategic intentions. | Irving I Gottesman, Todd D Gould | Am J Psychiatry | 2003 | 12668349 | No |
| 1411 | 5973 | 1991.0 | 212.0 | 70.7 | Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. | L Excoffier, P E Smouse, J M Quattro | Genetics | 1992 | 1644282 | Yes |
| 1412 | 1989 | 1989.0 | 73.7 | 73.7 | Transcriptional architecture of the mammalian circadian clock. | Joseph S Takahashi | Nat Rev Genet | 2017 | 27990019 | No |
| 1413 | 1988 | 1988.0 | 46.3 | 46.3 | Fabrication of novel biomaterials through molecular self-assembly. | Shuguang Zhang | Nat Biotechnol | 2003 | 14520402 | No |
| 1414 | 3976 | 1988.0 | 95.6 | 47.8 | Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. | Felix Krueger, Simon R Andrews | Bioinformatics | 2011 | 21493656 | Yes |
| 1415 | 1986 | 1986.0 | 68.6 | 68.6 | Physiological actions of taurine. | R J Huxtable | Physiol Rev | 1992 | 1731369 | No |
| 1416 | 1985 | 1985.0 | 51.3 | 51.3 | Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. | A Breslow | Ann Surg | 1970 | 5477666 | Yes |
| 1417 | 3970 | 1985.0 | 123.5 | 61.8 | Biofilms: survival mechanisms of clinically relevant microorganisms. | Rodney M Donlan, J William Costerton | Clin Microbiol Rev | 2002 | 11932229 | No |
| 1418 | 1984 | 1984.0 | 0.0 | 0.0 | On estimating the relation between blood group and disease. | B Woolf | Ann Hum Genet | 1955 | 14388528 | Yes |
| 1419 | 3968 | 1984.0 | 86.1 | 43.0 | Monocyte and macrophage heterogeneity. | Siamon Gordon, Philip R Taylor | Nat Rev Immunol | 2005 | 16322748 | No |
| 1420 | 1982 | 1982.0 | 60.9 | 60.9 | Leptospirosis. | P N Levett | Clin Microbiol Rev | 2001 | 11292640 | No |
| 1421 | 1982 | 1982.0 | 0.0 | 0.0 | Influences of glucose loading and of injected insulin on hepatic glucose output. | R Steele | Ann N Y Acad Sci | 1959 | 13833973 | Yes |
| 1422 | 1982 | 1982.0 | 45.8 | 45.8 | Integrating cell-signalling pathways with NF-kappaB and IKK function. | Neil D Perkins | Nat Rev Mol Cell Biol | 2007 | 17183360 | No |
| 1423 | 1981 | 1981.0 | 56.5 | 56.5 | Multiple imputation of discrete and continuous data by fully conditional specification. | Stef Van Buuren | Stat Methods Med Res | 2007 | 17621469 | Yes |
| 1424 | 1981 | 1981.0 | 76.0 | 76.0 | Antibiotics in the aquatic environment--a review--part I. | Klaus Kummerer | Chemosphere | 2009 | 19185900 | No |
| 1425 | 1979 | 1979.0 | 74.3 | 74.3 | Recognition-by-components: a theory of human image understanding. | Irving Biederman | Psychol Rev | 1987 | 3575582 | Yes |
| 1426 | 1979 | 1979.0 | 60.3 | 60.3 | Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. | A Dunaif | Endocr Rev | 1997 | 9408743 | No |
| 1427 | 3952 | 1976.0 | 103.7 | 51.9 | Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. | P J Barnes, M Karin | N Engl J Med | 1997 | 9091804 | No |
| 1428 | 1975 | 1975.0 | 49.6 | 49.6 | The dawning era of polymer therapeutics. | Ruth Duncan | Nat Rev Drug Discov | 2003 | 12750738 | No |
| 1429 | 3949 | 1974.5 | 128.0 | 64.0 | Oxygen toxicity, oxygen radicals, transition metals and disease. | B Halliwell, J M Gutteridge | Biochem J | 1984 | 6326753 | No |
| 1430 | 3944 | 1972.0 | 81.4 | 40.7 | Identification of common molecular subsequences. | T F Smith, M S Waterman | J Mol Biol | 1981 | 7265238 | Yes |
| 1431 | 1972 | 1972.0 | 44.1 | 44.1 | Recognition of microorganisms and activation of the immune response. | Ruslan Medzhitov | Nature | 2007 | 17943118 | No |
| 1432 | 1971 | 1971.0 | 49.6 | 49.6 | The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. | G S Manning | Q Rev Biophys | 1978 | 353876 | No |
| 1433 | 3939 | 1969.5 | 97.6 | 48.8 | Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. | A C Chang, S N Cohen | J Bacteriol | 1978 | 149110 | Yes |
| 1434 | 1969 | 1969.0 | 60.1 | 60.1 | Calbindin D-28k and parvalbumin in the rat nervous system. | M R Celio | Neuroscience | 1990 | 2199841 | Yes |
| 1435 | 1968 | 1968.0 | 51.4 | 51.4 | Cancer chemoprevention with dietary phytochemicals. | Young-Joon Surh | Nat Rev Cancer | 2003 | 14570043 | No |
| 1436 | 1967 | 1967.0 | 60.1 | 60.1 | Intracellular calcium homeostasis. | E Carafoli | Annu Rev Biochem | 1987 | 3304139 | No |
| 1437 | 5901 | 1967.0 | 175.2 | 58.4 | Median-joining networks for inferring intraspecific phylogenies. | H J Bandelt, P Forster, A Rohl | Mol Biol Evol | 1999 | 10331250 | Yes |
| 1438 | 1967 | 1967.0 | 59.3 | 59.3 | Semiempirical hybrid density functional with perturbative second-order correlation. | Stefan Grimme | J Chem Phys | 2006 | 16438568 | Yes |
| 1439 | 1966 | 1966.0 | 59.2 | 59.2 | Excitotoxic cell death. | D W Choi | J Neurobiol | 1992 | 1361523 | No |
| 1440 | 3932 | 1966.0 | 127.7 | 63.9 | Neurocircuitry of addiction. | George F Koob, Nora D Volkow | Neuropsychopharmacology | 2010 | 19710631 | No |
| 1441 | 1965 | 1965.0 | 89.7 | 89.7 | Adverse health effects of high-effort/low-reward conditions. | J Siegrist | J Occup Health Psychol | 1996 | 9547031 | No |
| 1442 | 1965 | 1965.0 | 52.1 | 52.1 | The hydrogen bond in the solid state. | Thomas Steiner | Angew Chem Int Ed Engl | 2002 | 12491444 | Yes |
| 1443 | 1965 | 1965.0 | 65.9 | 65.9 | A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. | Ozcan Erel | Clin Biochem | 2004 | 15003729 | Yes |
| 1444 | 13754 | 1964.9 | 534.4 | 76.3 | Assessing the quality of reports of randomized clinical trials: is blinding necessary? | A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay | Control Clin Trials | 1996 | 8721797 | Yes |
| 1445 | 1963 | 1963.0 | 58.2 | 58.2 | Porous scaffold design for tissue engineering. | Scott J Hollister | Nat Mater | 2005 | 16003400 | No |
| 1446 | 3925 | 1962.5 | 118.7 | 59.4 | Bronchopulmonary dysplasia. | A H Jobe, E Bancalari | Am J Respir Crit Care Med | 2001 | 11401896 | No |
| 1447 | 1962 | 1962.0 | 59.4 | 59.4 | Oxidative stress: oxidants and antioxidants. | H Sies | Exp Physiol | 1997 | 9129943 | No |
| 1448 | 3922 | 1961.0 | 73.8 | 36.9 | Rho GTPases in cell biology. | Sandrine Etienne-Manneville, Alan Hall | Nature | 2002 | 12478284 | No |
| 1449 | 1961 | 1961.0 | 42.6 | 42.6 | The hippo signaling pathway in development and cancer. | Duojia Pan | Dev Cell | 2010 | 20951342 | No |
| 1450 | 3921 | 1960.5 | 149.5 | 74.8 | Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. | M Mihara, M Uchiyama | Anal Biochem | 1978 | 655387 | Yes |
| 1451 | 3919 | 1959.5 | 79.2 | 39.6 | Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. | M Karin, Y Ben-Neriah | Annu Rev Immunol | 2000 | 10837071 | No |
| 1452 | 3916 | 1958.0 | 152.9 | 76.5 | Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. | M M Bradley, P J Lang | J Behav Ther Exp Psychiatry | 1994 | 7962581 | Yes |
| 1453 | 7831 | 1957.8 | 260.4 | 65.1 | The validity of the Hospital Anxiety and Depression Scale. An updated literature review. | Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann | J Psychosom Res | 2002 | 11832252 | No |
| 1454 | 1953 | 1953.0 | 87.2 | 87.2 | Mechanisms linking social ties and support to physical and mental health. | Peggy A Thoits | J Health Soc Behav | 2011 | 21673143 | No |
| 1455 | 1951 | 1951.0 | 44.0 | 44.0 | Signal sequences. The limits of variation. | G Von Heijne | J Mol Biol | 1985 | 4032478 | Yes |
| 1456 | 1951 | 1951.0 | 37.3 | 37.3 | Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. | M G Gustafsson | J Microsc | 2000 | 10810003 | Yes |
| 1457 | 1951 | 1951.0 | 46.1 | 46.1 | Cellular mechanisms of insulin resistance. | G I Shulman | J Clin Invest | 2000 | 10903330 | No |
| 1458 | 1951 | 1951.0 | 55.0 | 55.0 | The importance of the ratio of omega-6/omega-3 essential fatty acids. | A P Simopoulos | Biomed Pharmacother | 2002 | 12442909 | No |
| 1459 | 1950 | 1950.0 | 77.4 | 77.4 | Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. | A Fleckenstein | Annu Rev Pharmacol Toxicol | 1977 | 326161 | No |
| 1460 | 3899 | 1949.5 | 95.4 | 47.7 | Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. | I W McLean, P K Nakane | J Histochem Cytochem | 1974 | 4374474 | Yes |
| 1461 | 1949 | 1949.0 | 43.5 | 43.5 | Biology of natural killer cells. | G Trinchieri | Adv Immunol | 1989 | 2683611 | No |
| 1462 | 3897 | 1948.5 | 129.8 | 64.9 | miRBase: annotating high confidence microRNAs using deep sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2014 | 24275495 | Yes |
| 1463 | 1948 | 1948.0 | 48.4 | 48.4 | Evolutionary relationship of DNA sequences in finite populations. | F Tajima | Genetics | 1983 | 6628982 | Yes |
| 1464 | 5844 | 1948.0 | 127.7 | 42.6 | A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. | J H Zhang, T D Chung, K R Oldenburg | J Biomol Screen | 1999 | 10838414 | Yes |
| 1465 | 1948 | 1948.0 | 56.0 | 56.0 | The many roles for fluorine in medicinal chemistry. | William K Hagmann | J Med Chem | 2008 | 18570365 | Yes |
| 1466 | 11685 | 1947.5 | 322.8 | 53.8 | A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. | Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier | Science | 2012 | 22745249 | Yes |
| 1467 | 9732 | 1946.4 | 363.0 | 72.6 | UCHIME improves sensitivity and speed of chimera detection. | Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight | Bioinformatics | 2011 | 21700674 | Yes |
| 1468 | 1946 | 1946.0 | 0.0 | 0.0 | Evolutionary rate at the molecular level. | M Kimura | Nature | 1968 | 5637732 | Yes |
| 1469 | 1946 | 1946.0 | 34.9 | 34.9 | The regulation of E2F by pRB-family proteins. | N Dyson | Genes Dev | 1998 | 9694791 | No |
| 1470 | 5838 | 1946.0 | 140.7 | 46.9 | Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. | Michael W Pfaffl, Graham W Horgan, Leo Dempfle | Nucleic Acids Res | 2002 | 11972351 | Yes |
| 1471 | 1945 | 1945.0 | 48.7 | 48.7 | Tricine-SDS-PAGE. | Hermann Schagger | Nat Protoc | 2006 | 17406207 | Yes |
| 1472 | 5834 | 1944.7 | 180.2 | 60.1 | Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. | P A Wolf, R D Abbott, W B Kannel | Stroke | 1991 | 1866765 | Yes |
| 1473 | 13610 | 1944.3 | 471.2 | 67.3 | The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. | Erik Von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gotzsche, Jan P Vandenbroucke, | J Clin Epidemiol | 2008 | 18313558 | Yes |
| 1474 | 1944 | 1944.0 | 0.0 | 0.0 | The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. | S V Boyden | J Exp Med | 1951 | 14803635 | Yes |
| 1475 | 5830 | 1943.3 | 124.1 | 41.4 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel, J D Roberts, R A Zakour | Methods Enzymol | 1987 | 3323813 | Yes |
| 1476 | 1942 | 1942.0 | 48.4 | 48.4 | Thioredoxin. | A Holmgren | Annu Rev Biochem | 1985 | 3896121 | No |
| 1477 | 1941 | 1941.0 | 85.0 | 85.0 | Responses to depression and their effects on the duration of depressive episodes. | S Nolen-Hoeksema | J Abnorm Psychol | 1991 | 1757671 | No |
| 1478 | 1941 | 1941.0 | 59.2 | 59.2 | Intermediate filaments as mechanical integrators of cellular space. | E Lazarides | Nature | 1980 | 7188712 | Yes |
| 1479 | 3881 | 1940.5 | 96.7 | 48.4 | Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. | Christian Haass, Dennis J Selkoe | Nat Rev Mol Cell Biol | 2007 | 17245412 | No |
| 1480 | 1940 | 1940.0 | 90.6 | 90.6 | Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. | Kevin A Hallgren | Tutor Quant Methods Psychol | 2012 | 22833776 | Yes |
| 1481 | 1939 | 1939.0 | 67.2 | 67.2 | Constructions of masculinity and their influence on men's well-being: a theory of gender and health. | W H Courtenay | Soc Sci Med | 2000 | 10741575 | No |
| 1482 | 1939 | 1939.0 | 0.0 | 0.0 | Note on the sampling error of the difference between correlated proportions or percentages. | Q McNEMAR | Psychometrika | 1947 | 20254758 | Yes |
| 1483 | 1937 | 1937.0 | 41.3 | 41.3 | Oxidative stress shortens telomeres. | Thomas Von Zglinicki | Trends Biochem Sci | 2002 | 12114022 | Yes |
| 1484 | 3871 | 1935.5 | 132.5 | 66.2 | Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. | G Di Chiara, A Imperato | Proc Natl Acad Sci U S A | 1988 | 2899326 | Yes |
| 1485 | 9663 | 1932.6 | 227.9 | 45.6 | Stages of embryonic development of the zebrafish. | C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling | Dev Dyn | 1995 | 8589427 | Yes |
| 1486 | 3865 | 1932.5 | 106.6 | 53.3 | Inositol phosphates and cell signalling. | M J Berridge, R F Irvine | Nature | 1989 | 2550825 | No |
| 1487 | 1932 | 1932.0 | 48.7 | 48.7 | Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. | J P Chamberlain | Anal Biochem | 1979 | 543547 | Yes |
| 1488 | 1932 | 1932.0 | 51.7 | 51.7 | DNA topoisomerase poisons as antitumor drugs. | L F Liu | Annu Rev Biochem | 1989 | 2549853 | No |
| 1489 | 1932 | 1932.0 | 53.7 | 53.7 | Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. | H LeVine | Protein Sci | 1993 | 8453378 | Yes |
| 1490 | 1930 | 1930.0 | 63.5 | 63.5 | The global impact of pre-eclampsia and eclampsia. | Lelia Duley | Semin Perinatol | 2009 | 19464502 | No |
| 1491 | 3859 | 1929.5 | 140.0 | 70.0 | Cisplatin in cancer therapy: molecular mechanisms of action. | Shaloam Dasari, Paul Bernard Tchounwou | Eur J Pharmacol | 2014 | 25058905 | No |
| 1492 | 7716 | 1929.0 | 195.5 | 48.9 | p53 mutations in human cancers. | M Hollstein, D Sidransky, B Vogelstein, C C Harris | Science | 1991 | 1905840 | No |
| 1493 | 1929 | 1929.0 | 48.9 | 48.9 | Marine viruses--major players in the global ecosystem. | Curtis A Suttle | Nat Rev Microbiol | 2007 | 17853907 | No |
| 1494 | 1928 | 1928.0 | 68.0 | 68.0 | Ordinary magic. Resilience processes in development. | A S Masten | Am Psychol | 2001 | 11315249 | Yes |
| 1495 | 1925 | 1925.0 | 67.5 | 67.5 | The stress response in fish. | S E Wendelaar Bonga | Physiol Rev | 1997 | 9234959 | No |
| 1496 | 1924 | 1924.0 | 46.3 | 46.3 | The failing heart--an engine out of fuel. | Stefan Neubauer | N Engl J Med | 2007 | 17360992 | No |
| 1497 | 3847 | 1923.5 | 0.0 | 0.0 | Acetylornithinase of Escherichia coli: partial purification and some properties. | H J Vogel, D M Bonner | J Biol Chem | 1956 | 13278318 | Yes |
| 1498 | 3847 | 1923.5 | 156.4 | 78.2 | Interpreting findings from Mendelian randomization using the MR-Egger method. | Stephen Burgess, Simon G Thompson | Eur J Epidemiol | 2017 | 28527048 | Yes |
| 1499 | 1923 | 1923.0 | 36.3 | 36.3 | Network motifs: theory and experimental approaches. | Uri Alon | Nat Rev Genet | 2007 | 17510665 | No |
| 1500 | 1922 | 1922.0 | 47.6 | 47.6 | Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. | Z Yang | J Mol Evol | 1994 | 7932792 | Yes |
| 1501 | 1922 | 1922.0 | 72.3 | 72.3 | Inflammation, metaflammation and immunometabolic disorders. | Gokhan S Hotamisligil | Nature | 2017 | 28179656 | No |
| 1502 | 1920 | 1920.0 | 29.2 | 29.2 | Chromatin structure: a repeating unit of histones and DNA. | R D Kornberg | Science | 1974 | 4825889 | Yes |
| 1503 | 1920 | 1920.0 | 62.8 | 62.8 | Emotion regulation: affective, cognitive, and social consequences. | James J Gross | Psychophysiology | 2002 | 12212647 | No |
| 1504 | 1919 | 1919.0 | 44.7 | 44.7 | The Unified Medical Language System (UMLS): integrating biomedical terminology. | Olivier Bodenreider | Nucleic Acids Res | 2004 | 14681409 | Yes |
| 1505 | 3837 | 1918.5 | 202.2 | 101.1 | Interrater reliability of a modified Ashworth scale of muscle spasticity. | R W Bohannon, M B Smith | Phys Ther | 1987 | 3809245 | Yes |
| 1506 | 5754 | 1918.0 | 160.1 | 53.4 | A neural substrate of prediction and reward. | W Schultz, P Dayan, P R Montague | Science | 1997 | 9054347 | No |
| 1507 | 1914 | 1914.0 | 53.2 | 53.2 | A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. | P J Goodford | J Med Chem | 1985 | 3892003 | Yes |
| 1508 | 1914 | 1914.0 | 66.7 | 66.7 | The Resonating Valence Bond State in La2CuO4 and Superconductivity. | P W Anderson | Science | 1987 | 17818979 | Yes |
| 1509 | 1914 | 1914.0 | 68.1 | 68.1 | A Protection Motivation Theory of Fear Appeals and Attitude Change1. | Ronald W Rogers | J Psychol | 1975 | 28136248 | Yes |
| 1510 | 1913 | 1913.0 | 48.0 | 48.0 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1985 | 2992360 | No |
| 1511 | 3826 | 1913.0 | 109.8 | 54.9 | Alzheimer's disease. | Henry W Querfurth, Frank M LaFerla | N Engl J Med | 2010 | 20107219 | No |
| 1512 | 7650 | 1912.5 | 282.3 | 70.6 | FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. | Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs Schoffelen | Comput Intell Neurosci | 2011 | 21253357 | Yes |
| 1513 | 1912 | 1912.0 | 53.4 | 53.4 | In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. | T R Chen | Exp Cell Res | 1977 | 65285 | Yes |
| 1514 | 5736 | 1912.0 | 260.3 | 86.8 | Research diagnostic criteria: rationale and reliability. | R L Spitzer, J Endicott, E Robins | Arch Gen Psychiatry | 1978 | 655775 | Yes |
| 1515 | 3824 | 1912.0 | 88.3 | 44.1 | Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. | T Miyashita, J C Reed | Cell | 1995 | 7834749 | Yes |
| 1516 | 3823 | 1911.5 | 116.9 | 58.5 | The future of immune checkpoint therapy. | Padmanee Sharma, James P Allison | Science | 2015 | 25838373 | No |
| 1517 | 3822 | 1911.0 | 117.4 | 58.7 | Oxidative stress and diabetic complications. | Ferdinando Giacco, Michael Brownlee | Circ Res | 2010 | 21030723 | No |
| 1518 | 1909 | 1909.0 | 42.9 | 42.9 | The NCI60 human tumour cell line anticancer drug screen. | Robert H Shoemaker | Nat Rev Cancer | 2006 | 16990858 | No |
| 1519 | 1909 | 1909.0 | 47.3 | 47.3 | Five rules for the evolution of cooperation. | Martin A Nowak | Science | 2006 | 17158317 | No |
| 1520 | 1908 | 1908.0 | 49.3 | 49.3 | Cellular basis of working memory. | P S Goldman-Rakic | Neuron | 1995 | 7695894 | No |
| 1521 | 1908 | 1908.0 | 53.4 | 53.4 | Oxidative stress and neurodegeneration: where are we now? | Barry Halliwell | J Neurochem | 2006 | 16805774 | No |
| 1522 | 1907 | 1907.0 | 42.4 | 42.4 | The mitogen-activated protein kinase signal transduction pathway. | R J Davis | J Biol Chem | 1993 | 8325833 | No |
| 1523 | 3814 | 1907.0 | 93.9 | 47.0 | The future of genetic studies of complex human diseases. | N Risch, K Merikangas | Science | 1996 | 8801636 | Yes |
| 1524 | 1906 | 1906.0 | 61.7 | 61.7 | Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. | Joseph J Volpe | Lancet Neurol | 2009 | 19081519 | No |
| 1525 | 1905 | 1905.0 | 73.0 | 73.0 | A simple fluorometric assay for lipoperoxide in blood plasma. | K Yagi | Biochem Med | 1976 | 962904 | Yes |
| 1526 | 1905 | 1905.0 | 40.2 | 40.2 | Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. | R J Kaufman | Genes Dev | 1999 | 10346810 | No |
| 1527 | 9523 | 1904.6 | 405.3 | 81.1 | BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs. | Felipe A Simao, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M Zdobnov | Bioinformatics | 2015 | 26059717 | Yes |
| 1528 | 3809 | 1904.5 | 86.4 | 43.2 | Insulin signalling and the regulation of glucose and lipid metabolism. | A R Saltiel, C R Kahn | Nature | 2001 | 11742412 | Yes |
| 1529 | 1904 | 1904.0 | 73.9 | 73.9 | Multimodal approach to control postoperative pathophysiology and rehabilitation. | H Kehlet | Br J Anaesth | 1997 | 9175983 | No |
| 1530 | 1904 | 1904.0 | 49.5 | 49.5 | Adipose tissue, adipokines, and inflammation. | Giamila Fantuzzi | J Allergy Clin Immunol | 2005 | 15867843 | No |
| 1531 | 3807 | 1903.5 | 149.1 | 74.5 | MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. | Rajesha Rupaimoole, Frank J Slack | Nat Rev Drug Discov | 2017 | 28209991 | No |
| 1532 | 3804 | 1902.0 | 149.3 | 74.7 | The mini-mental state examination: a comprehensive review. | T N Tombaugh, N J McIntyre | J Am Geriatr Soc | 1992 | 1512391 | No |
| 1533 | 1902 | 1902.0 | 80.7 | 80.7 | The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. | Costantino Iadecola | Neuron | 2017 | 28957666 | No |
| 1534 | 3801 | 1900.5 | 82.7 | 41.4 | Cell death: critical control points. | Nika N Danial, Stanley J Korsmeyer | Cell | 2004 | 14744432 | No |
| 1535 | 5701 | 1900.3 | 139.0 | 46.3 | A new statistical method for haplotype reconstruction from population data. | M Stephens, N J Smith, P Donnelly | Am J Hum Genet | 2001 | 11254454 | Yes |
| 1536 | 1900 | 1900.0 | 90.2 | 90.2 | Determinants of low birth weight: methodological assessment and meta-analysis. | M S Kramer | Bull World Health Organ | 1987 | 3322602 | No |
| 1537 | 1900 | 1900.0 | 39.1 | 39.1 | Molecular regulation of vessel maturation. | Rakesh K Jain | Nat Med | 2003 | 12778167 | No |
| 1538 | 1900 | 1900.0 | 0.0 | 0.0 | The oxidation of ribonuclease with performic acid. | C H Hirs | J Biol Chem | 1956 | 13319283 | Yes |
| 1539 | 3799 | 1899.5 | 81.2 | 40.6 | Why do cancers have high aerobic glycolysis? | Robert A Gatenby, Robert J Gillies | Nat Rev Cancer | 2004 | 15516961 | No |
| 1540 | 1899 | 1899.0 | 43.9 | 43.9 | Two pathogenetic types of endometrial carcinoma. | J V Bokhman | Gynecol Oncol | 1983 | 6822361 | Yes |
| 1541 | 1899 | 1899.0 | 95.2 | 95.2 | Derivation and validation of a short-form oral health impact profile. | G D Slade | Community Dent Oral Epidemiol | 1997 | 9332805 | Yes |
| 1542 | 9492 | 1898.4 | 375.9 | 75.2 | Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption--II. | J B Saunders, O G Aasland, T F Babor, J R De La Fuente, M Grant | Addiction | 1993 | 8329970 | Yes |
| 1543 | 7593 | 1898.2 | 256.9 | 64.2 | Reporting results of cancer treatment. | A B Miller, B Hoogstraten, M Staquet, A Winkler | Cancer | 1981 | 7459811 | Yes |
| 1544 | 1898 | 1898.0 | 52.5 | 52.5 | Understanding biofilm resistance to antibacterial agents. | David Davies | Nat Rev Drug Discov | 2003 | 12563302 | No |
| 1545 | 1898 | 1898.0 | 37.1 | 37.1 | Cancer and the chemokine network. | Fran Balkwill | Nat Rev Cancer | 2004 | 15229479 | No |
| 1546 | 1898 | 1898.0 | 0.0 | 0.0 | A new readability yardstick. | R Flesch | J Appl Psychol | 1948 | 18867058 | Yes |
| 1547 | 1897 | 1897.0 | 36.0 | 36.0 | Cellular roles of DNA topoisomerases: a molecular perspective. | James C Wang | Nat Rev Mol Cell Biol | 2002 | 12042765 | No |
| 1548 | 1896 | 1896.0 | 40.8 | 40.8 | Points of control in inflammation. | Carl Nathan | Nature | 2002 | 12490957 | No |
| 1549 | 1896 | 1896.0 | 50.7 | 50.7 | Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. | Shitij Kapur | Am J Psychiatry | 2003 | 12505794 | No |
| 1550 | 1896 | 1896.0 | 56.4 | 56.4 | Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. | James J P Stewart | J Mol Model | 2007 | 17828561 | Yes |
| 1551 | 3791 | 1895.5 | 101.7 | 50.9 | A perspective on cancer cell metastasis. | Christine L Chaffer, Robert A Weinberg | Science | 2011 | 21436443 | No |
| 1552 | 1895 | 1895.0 | 65.9 | 65.9 | An overview of brominated flame retardants in the environment. | Cynthia A De Wit | Chemosphere | 2002 | 11999784 | No |
| 1553 | 3788 | 1894.0 | 80.4 | 40.2 | Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. | C D Nobes, A Hall | Cell | 1995 | 7536630 | Yes |
| 1554 | 1893 | 1893.0 | 41.7 | 41.7 | Excitatory actions of gaba during development: the nature of the nurture. | Yehezkel Ben-Ari | Nat Rev Neurosci | 2002 | 12209121 | No |
| 1555 | 3785 | 1892.5 | 93.3 | 46.6 | An efficient mRNA-dependent translation system from reticulocyte lysates. | H R Pelham, R J Jackson | Eur J Biochem | 1976 | 823012 | Yes |
| 1556 | 3785 | 1892.5 | 91.2 | 45.6 | Origins and Mechanisms of miRNAs and siRNAs. | Richard W Carthew, Erik J Sontheimer | Cell | 2009 | 19239886 | No |
| 1557 | 1892 | 1892.0 | 48.1 | 48.1 | The mitochondrial permeability transition pore and its role in cell death. | M Crompton | Biochem J | 1999 | 10393078 | No |
| 1558 | 7567 | 1891.8 | 231.0 | 57.8 | Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. | B Biswal, F Z Yetkin, V M Haughton, J S Hyde | Magn Reson Med | 1995 | 8524021 | Yes |
| 1559 | 1891 | 1891.0 | 78.2 | 78.2 | Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. | H U Wittchen | J Psychiatr Res | 1994 | 8064641 | No |
| 1560 | 20791 | 1890.1 | 549.5 | 50.0 | The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. | Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo | Genome Res | 2010 | 20644199 | Yes |
| 1561 | 1890 | 1890.0 | 77.5 | 77.5 | Brain dopamine receptors. | P Seeman | Pharmacol Rev | 1980 | 6117090 | No |
| 1562 | 1888 | 1888.0 | 48.5 | 48.5 | Complete nucleotide sequence of the Escherichia coli plasmid pBR322. | J G Sutcliffe | Cold Spring Harb Symp Quant Biol | 1979 | 383387 | Yes |
| 1563 | 3776 | 1888.0 | 0.0 | 0.0 | Receptive fields and functional architecture of monkey striate cortex. | D H Hubel, T N Wiesel | J Physiol | 1968 | 4966457 | Yes |
| 1564 | 3776 | 1888.0 | 111.5 | 55.8 | The mirror-neuron system. | Giacomo Rizzolatti, Laila Craighero | Annu Rev Neurosci | 2004 | 15217330 | No |
| 1565 | 1888 | 1888.0 | 48.7 | 48.7 | External validity of randomised controlled trials: "to whom do the results of this trial apply?". | Peter M Rothwell | Lancet | 2005 | 15639683 | Yes |
| 1566 | 1886 | 1886.0 | 38.7 | 38.7 | MicroRNA biogenesis: coordinated cropping and dicing. | V Narry Kim | Nat Rev Mol Cell Biol | 2005 | 15852042 | No |
| 1567 | 1886 | 1886.0 | 76.0 | 76.0 | Working memory: theories, models, and controversies. | Alan Baddeley | Annu Rev Psychol | 2012 | 21961947 | No |
| 1568 | 3771 | 1885.5 | 111.3 | 55.6 | Neoantigens in cancer immunotherapy. | Ton N Schumacher, Robert D Schreiber | Science | 2015 | 25838375 | No |
| 1569 | 3768 | 1884.0 | 129.1 | 64.5 | Separate visual pathways for perception and action. | M A Goodale, A D Milner | Trends Neurosci | 1992 | 1374953 | No |
| 1570 | 5650 | 1883.3 | 146.2 | 48.7 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. | Z N Oltvai, C L Milliman, S J Korsmeyer | Cell | 1993 | 8358790 | Yes |
| 1571 | 3765 | 1882.5 | 151.3 | 75.7 | Assays of glutathione peroxidase. | L Flohe, W A Gunzler | Methods Enzymol | 1984 | 6727659 | Yes |
| 1572 | 3764 | 1882.0 | 128.7 | 64.3 | Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. | R A DeFronzo, E Ferrannini | Diabetes Care | 1991 | 2044434 | No |
| 1573 | 1882 | 1882.0 | 71.2 | 71.2 | Simple proton spectroscopic imaging. | W T Dixon | Radiology | 1984 | 6089263 | Yes |
| 1574 | 3764 | 1882.0 | 127.7 | 63.9 | Role of the microbiota in immunity and inflammation. | Yasmine Belkaid, Timothy W Hand | Cell | 2014 | 24679531 | No |
| 1575 | 7527 | 1881.8 | 188.6 | 47.1 | Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. | A Shevchenko, M Wilm, O Vorm, M Mann | Anal Chem | 1996 | 8779443 | Yes |
| 1576 | 9409 | 1881.8 | 0.0 | 0.0 | Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. | S Katz, A B Ford, R W Moskowitz, B A Jackson, M W Jaffe | JAMA | 1963 | 14044222 | Yes |
| 1577 | 1880 | 1880.0 | 46.1 | 46.1 | PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. | Michael F Thomashow | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012220 | Yes |
| 1578 | 1879 | 1879.0 | 38.8 | 38.8 | The effect of infections on susceptibility to autoimmune and allergic diseases. | Jean-Francois Bach | N Engl J Med | 2002 | 12239261 | No |
| 1579 | 1879 | 1879.0 | 39.4 | 39.4 | Protein homology detection by HMM-HMM comparison. | Johannes Soding | Bioinformatics | 2005 | 15531603 | Yes |
| 1580 | 1878 | 1878.0 | 79.1 | 79.1 | Why patients use alternative medicine: results of a national study. | J A Astin | JAMA | 1998 | 9605899 | Yes |
| 1581 | 1876 | 1876.0 | 60.6 | 60.6 | Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. | M Zasloff | Proc Natl Acad Sci U S A | 1987 | 3299384 | Yes |
| 1582 | 1876 | 1876.0 | 48.4 | 48.4 | Clinical application of C-reactive protein for cardiovascular disease detection and prevention. | Paul M Ridker | Circulation | 2003 | 12551853 | No |
| 1583 | 1874 | 1874.0 | 61.9 | 61.9 | Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. | F Rousset | Genetics | 1997 | 9093870 | Yes |
| 1584 | 5621 | 1873.7 | 151.1 | 50.4 | The rapid generation of mutation data matrices from protein sequences. | D T Jones, W R Taylor, J M Thornton | Comput Appl Biosci | 1992 | 1633570 | Yes |
| 1585 | 1873 | 1873.0 | 56.9 | 56.9 | A classification of hand preference by association analysis. | M Annett | Br J Psychol | 1970 | 5457503 | Yes |
| 1586 | 9365 | 1873.0 | 330.0 | 66.0 | Integrating single-cell transcriptomic data across different conditions, technologies, and species. | Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul Satija | Nat Biotechnol | 2018 | 29608179 | Yes |
| 1587 | 1872 | 1872.0 | 36.7 | 36.7 | Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. | Judith Campisi | Cell | 2005 | 15734683 | No |
| 1588 | 1871 | 1871.0 | 39.3 | 39.3 | A cell culture model for T lymphocyte clonal anergy. | R H Schwartz | Science | 1990 | 2113314 | Yes |
| 1589 | 9350 | 1870.0 | 248.0 | 49.6 | Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. | Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-Yuan Hsu | N Engl J Med | 2004 | 15385656 | Yes |
| 1590 | 5607 | 1869.0 | 111.4 | 37.1 | Surfing the p53 network. | B Vogelstein, D Lane, A J Levine | Nature | 2000 | 11099028 | No |
| 1591 | 1869 | 1869.0 | 0.0 | 0.0 | The recurrence of intracranial meningiomas after surgical treatment. | D Simpson | J Neurol Neurosurg Psychiatry | 1957 | 13406590 | Yes |
| 1592 | 1868 | 1868.0 | 52.9 | 52.9 | Hepatitis B virus infection. | W M Lee | N Engl J Med | 1997 | 9392700 | No |
| 1593 | 1868 | 1868.0 | 0.0 | 0.0 | A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. | D A Robinson | IEEE Trans Biomed Eng | 1963 | 14121113 | Yes |
| 1594 | 1868 | 1868.0 | 87.6 | 87.6 | ROS Are Good. | Ron Mittler | Trends Plant Sci | 2017 | 27666517 | No |
| 1595 | 1866 | 1866.0 | 45.3 | 45.3 | A revolution in optical manipulation. | David G Grier | Nature | 2003 | 12917694 | No |
| 1596 | 14918 | 1864.8 | 426.6 | 53.3 | Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. | R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich | Science | 1988 | 2448875 | Yes |
| 1597 | 5593 | 1864.3 | 135.5 | 45.2 | Inflammation and atherosclerosis. | Peter Libby, Paul M Ridker, Attilio Maseri | Circulation | 2002 | 11877368 | No |
| 1598 | 9321 | 1864.2 | 268.9 | 53.8 | Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. | Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King | Diabetes Care | 2004 | 15111519 | Yes |
| 1599 | 3728 | 1864.0 | 120.5 | 60.2 | Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. | F Denizot, R Lang | J Immunol Methods | 1986 | 3486233 | Yes |
| 1600 | 3726 | 1863.0 | 88.1 | 44.0 | The Fas death factor. | S Nagata, P Golstein | Science | 1995 | 7533326 | No |
| 1601 | 3726 | 1863.0 | 116.9 | 58.5 | An information-maximization approach to blind separation and blind deconvolution. | A J Bell, T J Sejnowski | Neural Comput | 1995 | 7584893 | Yes |
| 1602 | 1862 | 1862.0 | 72.5 | 72.5 | Dual-task interference in simple tasks: data and theory. | H Pashler | Psychol Bull | 1994 | 7972591 | No |
| 1603 | 1862 | 1862.0 | 54.2 | 54.2 | Task switching. | Stephen Monsell | Trends Cogn Sci | 2003 | 12639695 | Yes |
| 1604 | 3724 | 1862.0 | 99.9 | 50.0 | Multiple sclerosis. | Alastair Compston, Alasdair Coles | Lancet | 2008 | 18970977 | Yes |
| 1605 | 1862 | 1862.0 | 81.9 | 81.9 | When to use the Bonferroni correction. | Richard A Armstrong | Ophthalmic Physiol Opt | 2014 | 24697967 | No |
| 1606 | 9306 | 1861.2 | 416.7 | 83.3 | CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes. | Donovan H Parks, Michael Imelfort, Connor T Skennerton, Philip Hugenholtz, Gene W Tyson | Genome Res | 2015 | 25977477 | Yes |
| 1607 | 1860 | 1860.0 | 46.4 | 46.4 | Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. | D Lavanchy | J Viral Hepat | 2004 | 14996343 | No |
| 1608 | 1859 | 1859.0 | 53.9 | 53.9 | Chlorpromazine equivalent doses for the newer atypical antipsychotics. | Scott W Woods | J Clin Psychiatry | 2003 | 12823080 | No |
| 1609 | 1859 | 1859.0 | 41.3 | 41.3 | Perceptions of epigenetics. | Adrian Bird | Nature | 2007 | 17522671 | Yes |
| 1610 | 1858 | 1858.0 | 50.8 | 50.8 | Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. | D M Neville | J Biol Chem | 1971 | 5127429 | Yes |
| 1611 | 1858 | 1858.0 | 41.8 | 41.8 | Hematopoietic stem-cell transplantation. | Edward A Copelan | N Engl J Med | 2006 | 16641398 | No |
| 1612 | 7430 | 1857.5 | 308.6 | 77.2 | 16S ribosomal DNA amplification for phylogenetic study. | W G Weisburg, S M Barns, D A Pelletier, D J Lane | J Bacteriol | 1991 | 1987160 | Yes |
| 1613 | 9287 | 1857.4 | 346.0 | 69.2 | Fsl. | Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M Smith | Neuroimage | 2012 | 21979382 | No |
| 1614 | 1857 | 1857.0 | 63.6 | 63.6 | Large-scale neurocognitive networks and distributed processing for attention, language, and memory. | M M Mesulam | Ann Neurol | 1990 | 2260847 | No |
| 1615 | 3712 | 1856.0 | 146.8 | 73.4 | The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities. | Samuel Genheden, Ulf Ryde | Expert Opin Drug Discov | 2015 | 25835573 | No |
| 1616 | 3711 | 1855.5 | 81.9 | 41.0 | Raster3D: photorealistic molecular graphics. | E A Merritt, D J Bacon | Methods Enzymol | 1997 | 18488322 | Yes |
| 1617 | 1855 | 1855.0 | 42.8 | 42.8 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1996 | 8811192 | No |
| 1618 | 7417 | 1854.2 | 261.6 | 65.4 | Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. | D J Sahn, A DeMaria, J Kisslo, A Weyman | Circulation | 1978 | 709763 | Yes |
| 1619 | 3708 | 1854.0 | 111.2 | 55.6 | Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. | Riccardo Lencioni, Josep M Llovet | Semin Liver Dis | 2010 | 20175033 | No |
| 1620 | 7412 | 1853.0 | 244.3 | 61.1 | A rating scale for mania: reliability, validity and sensitivity. | R C Young, J T Biggs, V E Ziegler, D A Meyer | Br J Psychiatry | 1978 | 728692 | Yes |
| 1621 | 1853 | 1853.0 | 50.6 | 50.6 | Efficient analysis of experimental observations. | W J Dixon | Annu Rev Pharmacol Toxicol | 1980 | 7387124 | Yes |
| 1622 | 3706 | 1853.0 | 0.0 | 0.0 | Convergent and discriminant validation by the multitrait-multimethod matrix. | D T Campbell, D W Fiske | Psychol Bull | 1959 | 13634291 | Yes |
| 1623 | 3705 | 1852.5 | 142.0 | 71.0 | The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. | A J Stunkard, S Messick | J Psychosom Res | 1985 | 3981480 | Yes |
| 1624 | 3704 | 1852.0 | 81.9 | 41.0 | Fibroblasts in cancer. | Raghu Kalluri, Michael Zeisberg | Nat Rev Cancer | 2006 | 16572188 | No |
| 1625 | 1852 | 1852.0 | 99.1 | 99.1 | Epidemiology of Prostate Cancer. | Prashanth Rawla | World J Oncol | 2019 | 31068988 | No |
| 1626 | 1851 | 1851.0 | 58.3 | 58.3 | Asthma phenotypes: the evolution from clinical to molecular approaches. | Sally E Wenzel | Nat Med | 2012 | 22561835 | No |
| 1627 | 1851 | 1851.0 | 81.0 | 81.0 | The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health. | Lisa Bowleg | Am J Public Health | 2012 | 22594719 | Yes |
| 1628 | 3702 | 1851.0 | 119.2 | 59.6 | Van der Waals heterostructures. | A K Geim, I V Grigorieva | Nature | 2013 | 23887427 | Yes |
| 1629 | 1850 | 1850.0 | 50.8 | 50.8 | Mitochondria and cancer. | Douglas C Wallace | Nat Rev Cancer | 2012 | 23001348 | No |
| 1630 | 1850 | 1850.0 | 69.3 | 69.3 | Nonalcoholic fatty liver disease: a systematic review. | Mary E Rinella | JAMA | 2015 | 26057287 | Yes |
| 1631 | 3700 | 1850.0 | 161.1 | 80.5 | Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2016 | 27095192 | Yes |
| 1632 | 1848 | 1848.0 | 77.3 | 77.3 | Biological roles of glycans. | Ajit Varki | Glycobiology | 2017 | 27558841 | No |
| 1633 | 7391 | 1847.8 | 150.6 | 37.6 | Stem cells, cancer, and cancer stem cells. | T Reya, S J Morrison, M F Clarke, I L Weissman | Nature | 2001 | 11689955 | No |
| 1634 | 1847 | 1847.0 | 0.0 | 0.0 | Protein denaturation. | C Tanford | Adv Protein Chem | 1968 | 4882248 | No |
| 1635 | 3694 | 1847.0 | 78.3 | 39.1 | Fitting a mixture model by expectation maximization to discover motifs in biopolymers. | T L Bailey, C Elkan | Proc Int Conf Intell Syst Mol Biol | 1994 | 7584402 | Yes |
| 1636 | 1847 | 1847.0 | 47.7 | 47.7 | Wound healing and its impairment in the diabetic foot. | Vincent Falanga | Lancet | 2005 | 16291068 | No |
| 1637 | 1847 | 1847.0 | 40.1 | 40.1 | Trastuzumab--mechanism of action and use in clinical practice. | Clifford A Hudis | N Engl J Med | 2007 | 17611206 | No |
| 1638 | 3693 | 1846.5 | 107.1 | 53.5 | Early identification of refractory epilepsy. | P Kwan, M J Brodie | N Engl J Med | 2000 | 10660394 | Yes |
| 1639 | 7386 | 1846.5 | 324.0 | 81.0 | NF-κB signaling in inflammation. | Ting Liu, Lingyun Zhang, Donghyun Joo, Shao-Cong Sun | Signal Transduct Target Ther | 2017 | 29158945 | Yes |
| 1640 | 1846 | 1846.0 | 0.0 | 0.0 | The influence of some cations on an adenosine triphosphatase from peripheral nerves. | J C Skou | Biochim Biophys Acta | 1957 | 13412736 | Yes |
| 1641 | 1846 | 1846.0 | 43.3 | 43.3 | Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. | Kang Xu | Chem Rev | 2004 | 15669157 | Yes |
| 1642 | 3692 | 1846.0 | 87.8 | 43.9 | The BCL-2 protein family: opposing activities that mediate cell death. | Richard J Youle, Andreas Strasser | Nat Rev Mol Cell Biol | 2008 | 18097445 | No |
| 1643 | 3692 | 1846.0 | 108.8 | 54.4 | Molecular and cellular insights into T cell exhaustion. | E John Wherry, Makoto Kurachi | Nat Rev Immunol | 2015 | 26205583 | No |
| 1644 | 3689 | 1844.5 | 86.2 | 43.1 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. | K D McCarthy, J De Vellis | J Cell Biol | 1980 | 6248568 | Yes |
| 1645 | 1844 | 1844.0 | 64.2 | 64.2 | The crisis in antibiotic resistance. | H C Neu | Science | 1992 | 1509257 | No |
| 1646 | 3688 | 1844.0 | 100.8 | 50.4 | Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. | Gerard Talavera, Jose Castresana | Syst Biol | 2007 | 17654362 | Yes |
| 1647 | 3687 | 1843.5 | 0.0 | 0.0 | Immunoassay of insulin with insulin-antibody precipitate. | C N Hales, P J Randle | Biochem J | 1963 | 13952078 | Yes |
| 1648 | 1842 | 1842.0 | 68.4 | 68.4 | Physiological aspects of primary hypertension. | B Folkow | Physiol Rev | 1982 | 6461865 | No |
| 1649 | 3683 | 1841.5 | 179.6 | 89.8 | Natural Products as Sources of New Drugs from 1981 to 2014. | David J Newman, Gordon M Cragg | J Nat Prod | 2016 | 26852623 | No |
| 1650 | 1840 | 1840.0 | 33.7 | 33.7 | The relationship between the spleen colony-forming cell and the haemopoietic stem cell. | R Schofield | Blood Cells | 1978 | 747780 | Yes |
| 1651 | 1840 | 1840.0 | 46.3 | 46.3 | Type III protein secretion systems in bacterial pathogens of animals and plants. | C J Hueck | Microbiol Mol Biol Rev | 1998 | 9618447 | No |
| 1652 | 5518 | 1839.3 | 190.1 | 63.4 | A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. | J R Le Gall, S Lemeshow, F Saulnier | JAMA | 1993 | 8254858 | Yes |
| 1653 | 1839 | 1839.0 | 91.1 | 91.1 | The structure and properties of the sense of coherence scale. | A Antonovsky | Soc Sci Med | 1993 | 8480217 | Yes |
| 1654 | 3677 | 1838.5 | 215.6 | 107.8 | Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. | Helmut Sies, Dean P Jones | Nat Rev Mol Cell Biol | 2020 | 32231263 | No |
| 1655 | 1838 | 1838.0 | 0.0 | 0.0 | Impulses and Physiological States in Theoretical Models of Nerve Membrane. | R Fitzhugh | Biophys J | 1961 | 19431309 | Yes |
| 1656 | 3674 | 1837.0 | 69.0 | 34.5 | The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. | J O'Keefe, J Dostrovsky | Brain Res | 1971 | 5124915 | Yes |
| 1657 | 1835 | 1835.0 | 32.0 | 32.0 | Amino acid difference formula to help explain protein evolution. | R Grantham | Science | 1974 | 4843792 | Yes |
| 1658 | 1835 | 1835.0 | 44.9 | 44.9 | New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. | R Y Tsien | Biochemistry | 1980 | 6770893 | Yes |
| 1659 | 1832 | 1832.0 | 47.1 | 47.1 | Synaptic density in human frontal cortex - developmental changes and effects of aging. | P R Huttenlocher | Brain Res | 1979 | 427544 | Yes |
| 1660 | 1832 | 1832.0 | 39.8 | 39.8 | Structure and regulation of voltage-gated Ca2+ channels. | W A Catterall | Annu Rev Cell Dev Biol | 2000 | 11031246 | No |
| 1661 | 1832 | 1832.0 | 41.9 | 41.9 | An approximately unbiased test of phylogenetic tree selection. | Hidetoshi Shimodaira | Syst Biol | 2002 | 12079646 | Yes |
| 1662 | 21969 | 1830.8 | 705.0 | 58.8 | A new equation to estimate glomerular filtration rate. | Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh, | Ann Intern Med | 2009 | 19414839 | Yes |
| 1663 | 1830 | 1830.0 | 64.4 | 64.4 | A cortical network for directed attention and unilateral neglect. | M M Mesulam | Ann Neurol | 1981 | 7032417 | No |
| 1664 | 5490 | 1830.0 | 139.9 | 46.6 | Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. | Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Orntoft | Cancer Res | 2004 | 15289330 | Yes |
| 1665 | 1830 | 1830.0 | 53.2 | 53.2 | Stress and depression. | Constance Hammen | Annu Rev Clin Psychol | 2005 | 17716090 | No |
| 1666 | 1830 | 1830.0 | 69.4 | 69.4 | Structure, Function, and Evolution of Coronavirus Spike Proteins. | Fang Li | Annu Rev Virol | 2016 | 27578435 | No |
| 1667 | 1829 | 1829.0 | 38.8 | 38.8 | Neurotrophins and their receptors: a convergence point for many signalling pathways. | Moses V Chao | Nat Rev Neurosci | 2003 | 12671646 | No |
| 1668 | 1828 | 1828.0 | 63.1 | 63.1 | Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. | S Katz | J Am Geriatr Soc | 1983 | 6418786 | No |
| 1669 | 5483 | 1827.7 | 136.7 | 45.6 | Membrane lipids: where they are and how they behave. | Gerrit Van Meer, Dennis R Voelker, Gerald W Feigenson | Nat Rev Mol Cell Biol | 2008 | 18216768 | No |
| 1670 | 1826 | 1826.0 | 0.0 | 0.0 | The genetical evolution of social behaviour. II. | W D Hamilton | J Theor Biol | 1964 | 5875340 | Yes |
| 1671 | 5476 | 1825.3 | 133.7 | 44.6 | A rapid method for the isolation of functional thymus-derived murine lymphocytes. | M H Julius, E Simpson, L A Herzenberg | Eur J Immunol | 1973 | 4587740 | Yes |
| 1672 | 1825 | 1825.0 | 0.0 | 0.0 | Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. | S Cohen | J Biol Chem | 1962 | 13880319 | Yes |
| 1673 | 3650 | 1825.0 | 94.9 | 47.5 | Molecular mechanisms of long noncoding RNAs. | Kevin C Wang, Howard Y Chang | Mol Cell | 2011 | 21925379 | No |
| 1674 | 3650 | 1825.0 | 137.4 | 68.7 | The Warburg Effect: How Does it Benefit Cancer Cells? | Maria V Liberti, Jason W Locasale | Trends Biochem Sci | 2016 | 26778478 | No |
| 1675 | 18244 | 1824.4 | 589.2 | 58.9 | Measurement of protein using bicinchoninic acid. | P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk | Anal Biochem | 1985 | 3843705 | Yes |
| 1676 | 3647 | 1823.5 | 90.8 | 45.4 | Adipose tissue as an endocrine organ. | Erin E Kershaw, Jeffrey S Flier | J Clin Endocrinol Metab | 2004 | 15181022 | No |
| 1677 | 3645 | 1822.5 | 87.7 | 43.9 | Cell signaling by receptor tyrosine kinases. | Mark A Lemmon, Joseph Schlessinger | Cell | 2010 | 20602996 | No |
| 1678 | 1820 | 1820.0 | 59.4 | 59.4 | Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. | Lutz Ackermann | Chem Rev | 2011 | 21391562 | Yes |
| 1679 | 3640 | 1820.0 | 120.1 | 60.0 | The M1 and M2 paradigm of macrophage activation: time for reassessment. | Fernando O Martinez, Siamon Gordon | F1000Prime Rep | 2014 | 24669294 | No |
| 1680 | 1819 | 1819.0 | 33.7 | 33.7 | Why genes in pieces? | W Gilbert | Nature | 1978 | 622185 | Yes |
| 1681 | 1819 | 1819.0 | 45.3 | 45.3 | Clinical features of metastatic bone disease and risk of skeletal morbidity. | Robert E Coleman | Clin Cancer Res | 2006 | 17062708 | No |
| 1682 | 3635 | 1817.5 | 138.8 | 69.4 | 3D bioprinting of tissues and organs. | Sean V Murphy, Anthony Atala | Nat Biotechnol | 2014 | 25093879 | Yes |
| 1683 | 1816 | 1816.0 | 40.4 | 40.4 | AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. | D Grahame Hardie | Nat Rev Mol Cell Biol | 2007 | 17712357 | No |
| 1684 | 3630 | 1815.0 | 95.8 | 47.9 | Morris water maze: procedures for assessing spatial and related forms of learning and memory. | Charles V Vorhees, Michael T Williams | Nat Protoc | 2006 | 17406317 | Yes |
| 1685 | 1815 | 1815.0 | 77.4 | 77.4 | PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. | Anthony L Spek | Acta Crystallogr C Struct Chem | 2015 | 25567569 | Yes |
| 1686 | 1814 | 1814.0 | 60.3 | 60.3 | Heavy metal intensification of DAB-based HRP reaction product. | J C Adams | J Histochem Cytochem | 1981 | 7252134 | Yes |
| 1687 | 1814 | 1814.0 | 53.4 | 53.4 | THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. | Kozi Asada | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012221 | Yes |
| 1688 | 3627 | 1813.5 | 106.0 | 53.0 | Quality control and preprocessing of metagenomic datasets. | Robert Schmieder, Robert Edwards | Bioinformatics | 2011 | 21278185 | Yes |
| 1689 | 1812 | 1812.0 | 41.6 | 41.6 | Tumor angiogenesis. | Robert S Kerbel | N Engl J Med | 2008 | 18463380 | No |
| 1690 | 1812 | 1812.0 | 60.8 | 60.8 | PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints. | Chun Wei Yap | J Comput Chem | 2011 | 21425294 | Yes |
| 1691 | 16301 | 1811.2 | 560.2 | 62.2 | The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. | D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar | J Clin Psychiatry | 1998 | 9881538 | No |
| 1692 | 1811 | 1811.0 | 71.7 | 71.7 | Rhythms for Cognition: Communication through Coherence. | Pascal Fries | Neuron | 2015 | 26447583 | No |
| 1693 | 9054 | 1810.8 | 324.8 | 65.0 | Salmon provides fast and bias-aware quantification of transcript expression. | Rob Patro, Geet Duggal, Michael I Love, Rafael A Irizarry, Carl Kingsford | Nat Methods | 2017 | 28263959 | Yes |
| 1694 | 1810 | 1810.0 | 62.9 | 62.9 | The linear-quadratic formula and progress in fractionated radiotherapy. | J F Fowler | Br J Radiol | 1989 | 2670032 | No |
| 1695 | 1807 | 1807.0 | 70.4 | 70.4 | Modeling and variable selection in epidemiologic analysis. | S Greenland | Am J Public Health | 1989 | 2916724 | Yes |
| 1696 | 3613 | 1806.5 | 144.1 | 72.0 | A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. | J G Snodgrass, M Vanderwart | J Exp Psychol Hum Learn | 1980 | 7373248 | Yes |
| 1697 | 3611 | 1805.5 | 90.0 | 45.0 | Protein folding in the cell. | M J Gething, J Sambrook | Nature | 1992 | 1731198 | No |
| 1698 | 3611 | 1805.5 | 96.5 | 48.2 | The biology of vascular endothelial growth factor. | N Ferrara, T Davis-Smyth | Endocr Rev | 1997 | 9034784 | No |
| 1699 | 1805 | 1805.0 | 61.2 | 61.2 | Pineal melatonin: cell biology of its synthesis and of its physiological interactions. | R J Reiter | Endocr Rev | 1991 | 1649044 | No |
| 1700 | 3610 | 1805.0 | 99.0 | 49.5 | Accessories to the crime: functions of cells recruited to the tumor microenvironment. | Douglas Hanahan, Lisa M Coussens | Cancer Cell | 2012 | 22439926 | No |
| 1701 | 1804 | 1804.0 | 64.8 | 64.8 | Paced auditory serial-addition task: a measure of recovery from concussion. | D M Gronwall | Percept Mot Skills | 1977 | 866038 | Yes |
| 1702 | 1803 | 1803.0 | 80.7 | 80.7 | Estimability and estimation in case-referent studies. | O Miettinen | Am J Epidemiol | 1976 | 1251836 | Yes |
| 1703 | 3606 | 1803.0 | 89.9 | 45.0 | Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. | Robert Visse, Hideaki Nagase | Circ Res | 2003 | 12730128 | No |
| 1704 | 1803 | 1803.0 | 57.0 | 57.0 | Amino acids: metabolism, functions, and nutrition. | Guoyao Wu | Amino Acids | 2009 | 19301095 | No |
| 1705 | 1802 | 1802.0 | 56.8 | 56.8 | The Hospital Anxiety And Depression Scale. | R Philip Snaith | Health Qual Life Outcomes | 2003 | 12914662 | Yes |
| 1706 | 1802 | 1802.0 | 0.0 | 0.0 | Notes on continuous stochastic phenomena. | P A P Moran | Biometrika | 1950 | 15420245 | Yes |
| 1707 | 1801 | 1801.0 | 40.8 | 40.8 | Areas, volumes, packing and protein structure. | F M Richards | Annu Rev Biophys Bioeng | 1977 | 326146 | No |
| 1708 | 1801 | 1801.0 | 0.0 | 0.0 | The measurement of volume changes in human limbs. | R J Whitney | J Physiol | 1953 | 13085295 | Yes |
| 1709 | 1801 | 1801.0 | 71.1 | 71.1 | Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation. | Karimollah Hajian-Tilaki | Caspian J Intern Med | 2013 | 24009950 | No |
| 1710 | 1801 | 1801.0 | 48.2 | 48.2 | BEDTools: The Swiss-Army Tool for Genome Feature Analysis. | Aaron R Quinlan | Curr Protoc Bioinformatics | 2014 | 25199790 | Yes |
| 1711 | 3601 | 1800.5 | 138.1 | 69.0 | Universal chemical assay for the detection and determination of siderophores. | B Schwyn, J B Neilands | Anal Biochem | 1987 | 2952030 | Yes |
| 1712 | 9001 | 1800.2 | 341.5 | 68.3 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | J Clin Epidemiol | 2009 | 19631508 | No |
| 1713 | 1799 | 1799.0 | 83.3 | 83.3 | Human agency in social cognitive theory. | A Bandura | Am Psychol | 1989 | 2782727 | Yes |
| 1714 | 1799 | 1799.0 | 39.7 | 39.7 | The tumor microenvironment and its role in promoting tumor growth. | T L Whiteside | Oncogene | 2008 | 18836471 | No |
| 1715 | 1797 | 1797.0 | 61.3 | 61.3 | Serum albumin. | T Peters | Adv Protein Chem | 1985 | 3904348 | No |
| 1716 | 1797 | 1797.0 | 35.9 | 35.9 | The synaptic vesicle cycle. | Thomas C Sudhof | Annu Rev Neurosci | 2004 | 15217342 | No |
| 1717 | 5391 | 1797.0 | 128.8 | 42.9 | Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. | Prateek Kumar, Steven Henikoff, Pauline C Ng | Nat Protoc | 2009 | 19561590 | Yes |
| 1718 | 1796 | 1796.0 | 33.2 | 33.2 | Simple memory: a theory for archicortex. | D Marr | Philos Trans R Soc Lond B Biol Sci | 1971 | 4399412 | Yes |
| 1719 | 1796 | 1796.0 | 51.7 | 51.7 | Oxidative stress hypothesis in Alzheimer's disease. | W R Markesbery | Free Radic Biol Med | 1997 | 9165306 | No |
| 1720 | 1796 | 1796.0 | 57.1 | 57.1 | Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. | E M Wassermann | Electroencephalogr Clin Neurophysiol | 1998 | 9474057 | No |
| 1721 | 1796 | 1796.0 | 63.3 | 63.3 | A Social Neuroscience Perspective on Adolescent Risk-Taking. | Laurence Steinberg | Dev Rev | 2008 | 18509515 | Yes |
| 1722 | 1795 | 1795.0 | 42.0 | 42.0 | Introduction to NF-kappaB: players, pathways, perspectives. | T D Gilmore | Oncogene | 2006 | 17072321 | No |
| 1723 | 5384 | 1794.7 | 119.2 | 39.7 | An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. | J K Eng, A L McCormack, J R Yates | J Am Soc Mass Spectrom | 1994 | 24226387 | Yes |
| 1724 | 1794 | 1794.0 | 0.0 | 0.0 | The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. | S Hestrin | J Biol Chem | 1949 | 18133390 | Yes |
| 1725 | 3587 | 1793.5 | 96.9 | 48.5 | EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. | Stefan Stoll, Arthur Schweiger | J Magn Reson | 2006 | 16188474 | Yes |
| 1726 | 1793 | 1793.0 | 65.0 | 65.0 | Computerized transverse axial scanning (tomography). 1. Description of system. | G N Hounsfield | Br J Radiol | 1973 | 4757352 | Yes |
| 1727 | 3585 | 1792.5 | 128.0 | 64.0 | Multiple receptors for dopamine. | J W Kebabian, D B Calne | Nature | 1979 | 215920 | No |
| 1728 | 3585 | 1792.5 | 129.7 | 64.8 | Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. | Roel Nusse, Hans Clevers | Cell | 2017 | 28575679 | No |
| 1729 | 1792 | 1792.0 | 65.2 | 65.2 | The case-crossover design: a method for studying transient effects on the risk of acute events. | M MacLure | Am J Epidemiol | 1991 | 1985444 | Yes |
| 1730 | 1792 | 1792.0 | 71.3 | 71.3 | Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. | K Anders Ericsson | Acad Med | 2004 | 15383395 | No |
| 1731 | 10745 | 1790.8 | 226.5 | 37.8 | Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. | A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello | Nature | 1998 | 9486653 | Yes |
| 1732 | 3581 | 1790.5 | 113.5 | 56.8 | Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. | Sally S Dickerson, Margaret E Kemeny | Psychol Bull | 2004 | 15122924 | Yes |
| 1733 | 1790 | 1790.0 | 35.9 | 35.9 | Generating samples under a Wright-Fisher neutral model of genetic variation. | Richard R Hudson | Bioinformatics | 2002 | 11847089 | Yes |
| 1734 | 1790 | 1790.0 | 0.0 | 0.0 | Cerebral vascular accidents in patients over the age of 60. II. Prognosis. | J Rankin | Scott Med J | 1957 | 13432835 | Yes |
| 1735 | 3579 | 1789.5 | 147.8 | 73.9 | A typology of reviews: an analysis of 14 review types and associated methodologies. | Maria J Grant, Andrew Booth | Health Info Libr J | 2009 | 19490148 | No |
| 1736 | 1788 | 1788.0 | 42.5 | 42.5 | Solvent-accessible surfaces of proteins and nucleic acids. | M L Connolly | Science | 1983 | 6879170 | Yes |
| 1737 | 5364 | 1788.0 | 299.3 | 99.8 | MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization. | Kazutaka Katoh, John Rozewicki, Kazunori D Yamada | Brief Bioinform | 2019 | 28968734 | Yes |
| 1738 | 3574 | 1787.0 | 150.1 | 75.0 | Assessment of eating disorders: interview or self-report questionnaire? | C G Fairburn, S J Beglin | Int J Eat Disord | 1994 | 7866415 | Yes |
| 1739 | 3574 | 1787.0 | 95.2 | 47.6 | The gut microbiota shapes intestinal immune responses during health and disease. | June L Round, Sarkis K Mazmanian | Nat Rev Immunol | 2009 | 19343057 | No |
| 1740 | 1786 | 1786.0 | 52.6 | 52.6 | Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4332693 | Yes |
| 1741 | 1786 | 1786.0 | 58.0 | 58.0 | ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps. | Tristan Ian Croll | Acta Crystallogr D Struct Biol | 2018 | 29872003 | Yes |
| 1742 | 3571 | 1785.5 | 81.2 | 40.6 | Escaping free-energy minima. | Alessandro Laio, Michele Parrinello | Proc Natl Acad Sci U S A | 2002 | 12271136 | Yes |
| 1743 | 1785 | 1785.0 | 41.2 | 41.2 | Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. | M J Casadaban | J Mol Biol | 1976 | 781293 | Yes |
| 1744 | 5355 | 1785.0 | 174.2 | 58.1 | Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. | H Esterbauer, R J Schaur, H Zollner | Free Radic Biol Med | 1991 | 1937131 | No |
| 1745 | 1785 | 1785.0 | 72.7 | 72.7 | A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. | D J Schuirmann | J Pharmacokinet Biopharm | 1987 | 3450848 | Yes |
| 1746 | 1784 | 1784.0 | 47.7 | 47.7 | A more meaningful scoring system for determining the severity of coronary heart disease. | G G Gensini | Am J Cardiol | 1983 | 6823874 | Yes |
| 1747 | 1783 | 1783.0 | 37.9 | 37.9 | An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. | R M Esnouf | J Mol Graph Model | 1997 | 9385560 | Yes |
| 1748 | 3565 | 1782.5 | 95.8 | 47.9 | Matrix metalloproteinases. | H Nagase, J F Woessner | J Biol Chem | 1999 | 10419448 | No |
| 1749 | 3565 | 1782.5 | 107.9 | 54.0 | Density functionals with broad applicability in chemistry. | Yan Zhao, Donald G Truhlar | Acc Chem Res | 2008 | 18186612 | Yes |
| 1750 | 1782 | 1782.0 | 58.0 | 58.0 | The in vitro micronucleus technique. | M Fenech | Mutat Res | 2000 | 11113469 | No |
| 1751 | 1782 | 1782.0 | 42.3 | 42.3 | In vivo near-infrared fluorescence imaging. | John V Frangioni | Curr Opin Chem Biol | 2003 | 14580568 | No |
| 1752 | 7125 | 1781.2 | 310.7 | 77.7 | The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. | S P Baker, B O'Neill, W Haddon, W B Long | J Trauma | 1974 | 4814394 | Yes |
| 1753 | 3561 | 1780.5 | 96.9 | 48.5 | Maturation of the head of bacteriophage T4. I. DNA packaging events. | U K Laemmli, M Favre | J Mol Biol | 1973 | 4204102 | Yes |
| 1754 | 3560 | 1780.0 | 85.4 | 42.7 | Lipopolysaccharide endotoxins. | Christian R H Raetz, Chris Whitfield | Annu Rev Biochem | 2002 | 12045108 | No |
| 1755 | 3559 | 1779.5 | 125.4 | 62.7 | A fluorometric method for determination of oxidized and reduced glutathione in tissues. | P J Hissin, R Hilf | Anal Biochem | 1976 | 962076 | Yes |
| 1756 | 1778 | 1778.0 | 29.9 | 29.9 | Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. | J N Dumont | J Morphol | 1972 | 4109871 | Yes |
| 1757 | 1775 | 1775.0 | 63.3 | 63.3 | Drugs of abuse: anatomy, pharmacology and function of reward pathways. | G F Koob | Trends Pharmacol Sci | 1992 | 1604710 | No |
| 1758 | 1775 | 1775.0 | 61.1 | 61.1 | The law of attrition. | Gunther Eysenbach | J Med Internet Res | 2005 | 15829473 | Yes |
| 1759 | 3549 | 1774.5 | 78.4 | 39.2 | Integrin signaling. | F G Giancotti, E Ruoslahti | Science | 1999 | 10446041 | No |
| 1760 | 3549 | 1774.5 | 92.5 | 46.2 | Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. | Steven E Nissen, Kathy Wolski | N Engl J Med | 2007 | 17517853 | Yes |
| 1761 | 3549 | 1774.5 | 117.3 | 58.6 | Mendelian randomization: genetic anchors for causal inference in epidemiological studies. | George Davey Smith, Gibran Hemani | Hum Mol Genet | 2014 | 25064373 | No |
| 1762 | 3548 | 1774.0 | 173.4 | 86.7 | The structure of coping. | L I Pearlin, C Schooler | J Health Soc Behav | 1978 | 649936 | Yes |
| 1763 | 1773 | 1773.0 | 69.9 | 69.9 | MorphoJ: an integrated software package for geometric morphometrics. | Christian Peter Klingenberg | Mol Ecol Resour | 2011 | 21429143 | Yes |
| 1764 | 1769 | 1769.0 | 30.4 | 30.4 | Mode of cell migration to the superficial layers of fetal monkey neocortex. | P Rakic | J Comp Neurol | 1972 | 4624784 | Yes |
| 1765 | 3538 | 1769.0 | 201.0 | 100.5 | Osteoarthritis. | David J Hunter, Sita Bierma-Zeinstra | Lancet | 2019 | 31034380 | No |
| 1766 | 3537 | 1768.5 | 0.0 | 0.0 | A complementation analysis of the restriction and modification of DNA in Escherichia coli. | H W Boyer, D Roulland-Dussoix | J Mol Biol | 1969 | 4896022 | Yes |
| 1767 | 3537 | 1768.5 | 76.2 | 38.1 | The epigenomics of cancer. | Peter A Jones, Stephen B Baylin | Cell | 2007 | 17320506 | No |
| 1768 | 1768 | 1768.0 | 48.1 | 48.1 | Interleukin-6: an overview. | J Van Snick | Annu Rev Immunol | 1990 | 2188664 | No |
| 1769 | 3535 | 1767.5 | 233.2 | 116.6 | A clinical method of functional assessment of the shoulder. | C R Constant, A H Murley | Clin Orthop Relat Res | 1987 | 3791738 | Yes |
| 1770 | 1767 | 1767.0 | 0.0 | 0.0 | Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. | J Spizizen | Proc Natl Acad Sci U S A | 1958 | 16590310 | Yes |
| 1771 | 1767 | 1767.0 | 76.7 | 76.7 | Sleep health: can we define it? Does it matter? | Daniel J Buysse | Sleep | 2014 | 24470692 | Yes |
| 1772 | 1766 | 1766.0 | 41.7 | 41.7 | Angiogenesis: an organizing principle for drug discovery? | Judah Folkman | Nat Rev Drug Discov | 2007 | 17396134 | No |
| 1773 | 3531 | 1765.5 | 94.3 | 47.1 | Prediction of protein antigenic determinants from amino acid sequences. | T P Hopp, K R Woods | Proc Natl Acad Sci U S A | 1981 | 6167991 | Yes |
| 1774 | 3531 | 1765.5 | 75.4 | 37.7 | Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. | Gary L Johnson, Razvan Lapadat | Science | 2002 | 12471242 | No |
| 1775 | 1765 | 1765.0 | 50.0 | 50.0 | Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. | Charles A Dinarello | Blood | 2011 | 21304099 | No |
| 1776 | 7057 | 1764.2 | 177.0 | 44.2 | CHARMM-GUI: a web-based graphical user interface for CHARMM. | Sunhwan Jo, Taehoon Kim, Vidyashankara G Iyer, Wonpil Im | J Comput Chem | 2008 | 18351591 | No |
| 1777 | 1764 | 1764.0 | 0.0 | 0.0 | ATPase activity of myosin correlated with speed of muscle shortening. | M Barany | J Gen Physiol | 1967 | 4227924 | Yes |
| 1778 | 1764 | 1764.0 | 65.2 | 65.2 | Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? | B Halliwell | Lancet | 1994 | 7915779 | No |
| 1779 | 7052 | 1763.0 | 232.6 | 58.1 | SignalP 4.0: discriminating signal peptides from transmembrane regions. | Thomas Nordahl Petersen, Soren Brunak, Gunnar Von Heijne, Henrik Nielsen | Nat Methods | 2011 | 21959131 | Yes |
| 1780 | 1762 | 1762.0 | 51.0 | 51.0 | Surface plasmon resonance sensors for detection of chemical and biological species. | Jiri Homola | Chem Rev | 2008 | 18229953 | No |
| 1781 | 1761 | 1761.0 | 43.3 | 43.3 | Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. | S A Bustin | J Mol Endocrinol | 2002 | 12200227 | No |
| 1782 | 1760 | 1760.0 | 0.0 | 0.0 | A personality scale of manifest anxiety. | J A Taylor | J Abnorm Psychol | 1953 | 13052352 | Yes |
| 1783 | 1759 | 1759.0 | 56.2 | 56.2 | Glutamate: a neurotransmitter in mammalian brain. | F Fonnum | J Neurochem | 1984 | 6139418 | No |
| 1784 | 3518 | 1759.0 | 73.0 | 36.5 | The evolutionary fate and consequences of duplicate genes. | M Lynch, J S Conery | Science | 2000 | 11073452 | No |
| 1785 | 5276 | 1758.7 | 217.8 | 72.6 | Impact of Event Scale: a measure of subjective stress. | M Horowitz, N Wilner, W Alvarez | Psychosom Med | 1979 | 472086 | Yes |
| 1786 | 1758 | 1758.0 | 41.3 | 41.3 | Steroid receptor regulated transcription of specific genes and gene networks. | K R Yamamoto | Annu Rev Genet | 1985 | 3909942 | No |
| 1787 | 1758 | 1758.0 | 31.1 | 31.1 | Transplacental carcinogenesis by stilbestrol. | J Folkman | N Engl J Med | 1971 | 5556579 | Yes |
| 1788 | 7032 | 1758.0 | 284.8 | 71.2 | Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. | Jack Bowden, George Davey Smith, Philip C Haycock, Stephen Burgess | Genet Epidemiol | 2016 | 27061298 | Yes |
| 1789 | 3515 | 1757.5 | 76.0 | 38.0 | A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. | D Wessel, U I Flugge | Anal Biochem | 1984 | 6731838 | Yes |
| 1790 | 1757 | 1757.0 | 49.1 | 49.1 | G proteins and dual control of adenylate cyclase. | A G Gilman | Cell | 1984 | 6321035 | Yes |
| 1791 | 1757 | 1757.0 | 39.7 | 39.7 | The synaptic vesicle cycle: a cascade of protein-protein interactions. | T C Sudhof | Nature | 1995 | 7791897 | No |
| 1792 | 3512 | 1756.0 | 97.0 | 48.5 | Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. | K B Mullis, F A Faloona | Methods Enzymol | 1987 | 3431465 | Yes |
| 1793 | 1756 | 1756.0 | 71.6 | 71.6 | Negative symptoms in schizophrenia. Definition and reliability. | N C Andreasen | Arch Gen Psychiatry | 1982 | 7165477 | Yes |
| 1794 | 1756 | 1756.0 | 39.3 | 39.3 | Critical period plasticity in local cortical circuits. | Takao K Hensch | Nat Rev Neurosci | 2005 | 16261181 | No |
| 1795 | 1756 | 1756.0 | 150.3 | 150.3 | COVID-19 and mental health: A review of the existing literature. | Ravi Philip Rajkumar | Asian J Psychiatr | 2020 | 32302935 | Yes |
| 1796 | 5266 | 1755.3 | 115.4 | 38.5 | Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. | J E Darnell, I M Kerr, G R Stark | Science | 1994 | 8197455 | No |
| 1797 | 1755 | 1755.0 | 39.6 | 39.6 | Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. | A Krishan | J Cell Biol | 1975 | 49354 | Yes |
| 1798 | 1755 | 1755.0 | 56.6 | 56.6 | Dynamic properties of mammalian skeletal muscles. | R I Close | Physiol Rev | 1972 | 4256989 | No |
| 1799 | 5265 | 1755.0 | 227.0 | 75.7 | The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. | C A McHorney, J E Ware, A E Raczek | Med Care | 1993 | 8450681 | Yes |
| 1800 | 3509 | 1754.5 | 77.6 | 38.8 | Cellular senescence: when bad things happen to good cells. | Judith Campisi, Fabrizio D'Adda Di Fagagna | Nat Rev Mol Cell Biol | 2007 | 17667954 | No |
| 1801 | 1754 | 1754.0 | 0.0 | 0.0 | Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. | A F Habeeb | Anal Biochem | 1966 | 4161471 | Yes |
| 1802 | 7014 | 1753.5 | 316.9 | 79.2 | Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. | Marie Verbanck, Chia-Yen Chen, Benjamin Neale, Ron Do | Nat Genet | 2018 | 29686387 | Yes |
| 1803 | 7012 | 1753.0 | 139.0 | 34.8 | Transformation of intact yeast cells treated with alkali cations. | H Ito, Y Fukuda, K Murata, A Kimura | J Bacteriol | 1983 | 6336730 | Yes |
| 1804 | 10518 | 1753.0 | 304.0 | 50.7 | Positional cloning of the mouse obese gene and its human homologue. | Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman | Nature | 1994 | 7984236 | Yes |
| 1805 | 1753 | 1753.0 | 42.4 | 42.4 | Neurovascular regulation in the normal brain and in Alzheimer's disease. | Costantino Iadecola | Nat Rev Neurosci | 2004 | 15100718 | No |
| 1806 | 1751 | 1751.0 | 52.5 | 52.5 | The basal ganglia: focused selection and inhibition of competing motor programs. | J W Mink | Prog Neurobiol | 1996 | 9004351 | No |
| 1807 | 3502 | 1751.0 | 108.9 | 54.5 | The cortical organization of speech processing. | Gregory Hickok, David Poeppel | Nat Rev Neurosci | 2007 | 17431404 | No |
| 1808 | 10505 | 1750.8 | 399.0 | 66.5 | Antioxidant activity applying an improved ABTS radical cation decolorization assay. | R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans | Free Radic Biol Med | 1999 | 10381194 | Yes |
| 1809 | 7001 | 1750.2 | 237.5 | 59.4 | Near-optimal probabilistic RNA-seq quantification. | Nicolas L Bray, Harold Pimentel, Pall Melsted, Lior Pachter | Nat Biotechnol | 2016 | 27043002 | Yes |
| 1810 | 5249 | 1749.7 | 153.6 | 51.2 | Dose translation from animal to human studies revisited. | Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad | FASEB J | 2008 | 17942826 | Yes |
| 1811 | 3499 | 1749.5 | 93.8 | 46.9 | Quantum dot bioconjugates for ultrasensitive nonisotopic detection. | W C Chan, S Nie | Science | 1998 | 9748158 | Yes |
| 1812 | 1749 | 1749.0 | 59.0 | 59.0 | Phenylpropanoid biosynthesis. | Thomas Vogt | Mol Plant | 2010 | 20035037 | No |
| 1813 | 1749 | 1749.0 | 387.7 | 387.7 | A comprehensive electron wavefunction analysis toolbox for chemists, Multiwfn. | Tian Lu | J Chem Phys | 2024 | 39189657 | Yes |
| 1814 | 1748 | 1748.0 | 40.9 | 40.9 | Effects of cytochalasin and phalloidin on actin. | J A Cooper | J Cell Biol | 1987 | 3312229 | No |
| 1815 | 3496 | 1748.0 | 209.9 | 105.0 | Rating systems in the evaluation of knee ligament injuries. | Y Tegner, J Lysholm | Clin Orthop Relat Res | 1985 | 4028566 | Yes |
| 1816 | 1748 | 1748.0 | 56.0 | 56.0 | The role of hormone receptors and GTP-regulatory proteins in membrane transduction. | M Rodbell | Nature | 1980 | 6101906 | Yes |
| 1817 | 1748 | 1748.0 | 35.8 | 35.8 | DNA in a material world. | Nadrian C Seeman | Nature | 2003 | 12540916 | No |
| 1818 | 3495 | 1747.5 | 77.6 | 38.8 | The DNA damage response: making it safe to play with knives. | Alberto Ciccia, Stephen J Elledge | Mol Cell | 2010 | 20965415 | No |
| 1819 | 1747 | 1747.0 | 49.6 | 49.6 | Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. | M Wong-Riley | Brain Res | 1979 | 223730 | Yes |
| 1820 | 3494 | 1747.0 | 91.1 | 45.5 | CAP3: A DNA sequence assembly program. | X Huang, A Madan | Genome Res | 1999 | 10508846 | Yes |
| 1821 | 3493 | 1746.5 | 117.7 | 58.9 | Thermodynamics of protein association reactions: forces contributing to stability. | P D Ross, S Subramanian | Biochemistry | 1981 | 7248271 | Yes |
| 1822 | 3493 | 1746.5 | 263.9 | 131.9 | Gut microbiota in human metabolic health and disease. | Yong Fan, Oluf Pedersen | Nat Rev Microbiol | 2021 | 32887946 | No |
| 1823 | 3492 | 1746.0 | 77.5 | 38.8 | The Ki-67 protein: from the known and the unknown. | T Scholzen, J Gerdes | J Cell Physiol | 2000 | 10653597 | No |
| 1824 | 1746 | 1746.0 | 0.0 | 0.0 | The general adaptation syndrome and the diseases of adaptation. | H Selye | J Clin Endocrinol Metab | 1946 | 21025115 | Yes |
| 1825 | 3491 | 1745.5 | 81.7 | 40.9 | Neurotrophins: roles in neuronal development and function. | E J Huang, L F Reichardt | Annu Rev Neurosci | 2001 | 11520916 | No |
| 1826 | 3491 | 1745.5 | 85.0 | 42.5 | Unravelling the pathogenesis of inflammatory bowel disease. | R J Xavier, D K Podolsky | Nature | 2007 | 17653185 | No |
| 1827 | 1745 | 1745.0 | 32.5 | 32.5 | Neuroblastoma: biological insights into a clinical enigma. | Garrett M Brodeur | Nat Rev Cancer | 2003 | 12612655 | No |
| 1828 | 1745 | 1745.0 | 51.0 | 51.0 | Signal transduction by reactive oxygen species. | Toren Finkel | J Cell Biol | 2011 | 21746850 | No |
| 1829 | 17422 | 1742.2 | 569.6 | 57.0 | The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. | F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra | Arthritis Rheum | 1988 | 3358796 | Yes |
| 1830 | 5226 | 1742.0 | 124.3 | 41.4 | Click Chemistry: Diverse Chemical Function from a Few Good Reactions. | Hartmuth C Kolb, M G Finn, K Barry Sharpless | Angew Chem Int Ed Engl | 2001 | 11433435 | Yes |
| 1831 | 5224 | 1741.3 | 135.7 | 45.2 | Optimization by simulated annealing. | S Kirkpatrick, C D Gelatt, M P Vecchi | Science | 1983 | 17813860 | Yes |
| 1832 | 1741 | 1741.0 | 75.6 | 75.6 | The micronucleus test. | W Schmid | Mutat Res | 1975 | 48190 | Yes |
| 1833 | 1741 | 1741.0 | 57.0 | 57.0 | A measure of population subdivision based on microsatellite allele frequencies. | M Slatkin | Genetics | 1995 | 7705646 | Yes |
| 1834 | 3482 | 1741.0 | 77.8 | 38.9 | Self-assembly at all scales. | George M Whitesides, Bartosz Grzybowski | Science | 2002 | 11923529 | Yes |
| 1835 | 1740 | 1740.0 | 58.3 | 58.3 | Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. | C E Mogensen | N Engl J Med | 1984 | 6690964 | Yes |
| 1836 | 1740 | 1740.0 | 53.3 | 53.3 | Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. | P A Bradford | Clin Microbiol Rev | 2001 | 11585791 | No |
| 1837 | 1739 | 1739.0 | 51.9 | 51.9 | The fetal and infant origins of adult disease. | D J Barker | BMJ | 1990 | 2252919 | No |
| 1838 | 3474 | 1737.0 | 113.7 | 56.9 | Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. | G R Gibson, M B Roberfroid | J Nutr | 1995 | 7782892 | No |
| 1839 | 5209 | 1736.3 | 192.9 | 64.3 | Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. | C J Caspersen, K E Powell, G M Christenson | Public Health Rep | 1985 | 3920711 | Yes |
| 1840 | 1736 | 1736.0 | 32.7 | 32.7 | Cyclin-dependent kinases: engines, clocks, and microprocessors. | D O Morgan | Annu Rev Cell Dev Biol | 1997 | 9442875 | No |
| 1841 | 1736 | 1736.0 | 41.7 | 41.7 | Neurotrophin-regulated signalling pathways. | Louis F Reichardt | Philos Trans R Soc Lond B Biol Sci | 2006 | 16939974 | No |
| 1842 | 3471 | 1735.5 | 94.3 | 47.1 | Cloned glutamate receptors. | M Hollmann, S Heinemann | Annu Rev Neurosci | 1994 | 8210177 | No |
| 1843 | 1735 | 1735.0 | 60.9 | 60.9 | Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. | George S Bloom | JAMA Neurol | 2014 | 24493463 | No |
| 1844 | 10408 | 1734.7 | 324.7 | 54.1 | The Molecular Signatures Database (MSigDB) hallmark gene set collection. | Arthur Liberzon, Chet Birger, Helga Thorvaldsdottir, Mahmoud Ghandi, Jill P Mesirov, Pablo Tamayo | Cell Syst | 2015 | 26771021 | Yes |
| 1845 | 1733 | 1733.0 | 70.8 | 70.8 | Probiotics in man and animals. | R Fuller | J Appl Bacteriol | 1989 | 2666378 | No |
| 1846 | 1733 | 1733.0 | 31.8 | 31.8 | How eukaryotic transcriptional activators work. | M Ptashne | Nature | 1988 | 3050531 | No |
| 1847 | 1732 | 1732.0 | 0.0 | 0.0 | Cerebral blood flow and oxygen consumption in man. | N A Lassen | Physiol Rev | 1959 | 13645234 | Yes |
| 1848 | 1732 | 1732.0 | 43.0 | 43.0 | The biology of incretin hormones. | Daniel J Drucker | Cell Metab | 2006 | 16517403 | No |
| 1849 | 1732 | 1732.0 | 91.1 | 91.1 | Cell death: a review of the major forms of apoptosis, necrosis and autophagy. | Mark S D'Arcy | Cell Biol Int | 2019 | 30958602 | No |
| 1850 | 1731 | 1731.0 | 66.2 | 66.2 | Cyclosporine. | B D Kahan | N Engl J Med | 1989 | 2687689 | No |
| 1851 | 1731 | 1731.0 | 39.5 | 39.5 | Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. | S L Friedman | J Biol Chem | 2000 | 10644669 | No |
| 1852 | 1730 | 1730.0 | 46.1 | 46.1 | The pathophysiology of tumor necrosis factors. | P Vassalli | Annu Rev Immunol | 1992 | 1590993 | No |
| 1853 | 12110 | 1730.0 | 297.8 | 42.5 | Integrative genomics viewer. | James T Robinson, Helga Thorvaldsdottir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P Mesirov | Nat Biotechnol | 2011 | 21221095 | Yes |
| 1854 | 1730 | 1730.0 | 67.5 | 67.5 | 1,500 scientists lift the lid on reproducibility. | Monya Baker | Nature | 2016 | 27225100 | No |
| 1855 | 5187 | 1729.0 | 115.6 | 38.5 | Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. | A Nicholls, K A Sharp, B Honig | Proteins | 1991 | 1758883 | Yes |
| 1856 | 1729 | 1729.0 | 37.5 | 37.5 | Topoisomerase I inhibitors: camptothecins and beyond. | Yves Pommier | Nat Rev Cancer | 2006 | 16990856 | No |
| 1857 | 1728 | 1728.0 | 46.4 | 46.4 | Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. | E M Witkin | Bacteriol Rev | 1976 | 795416 | No |
| 1858 | 1728 | 1728.0 | 81.1 | 81.1 | Chronic illness as biographical disruption. | M Bury | Sociol Health Illn | 1982 | 10260456 | Yes |
| 1859 | 1728 | 1728.0 | 48.0 | 48.0 | Interoception: the sense of the physiological condition of the body. | A D Craig | Curr Opin Neurobiol | 2003 | 12965300 | No |
| 1860 | 5184 | 1728.0 | 327.5 | 109.2 | Correlation Coefficients: Appropriate Use and Interpretation. | Patrick Schober, Christa Boer, Lothar A Schwarte | Anesth Analg | 2018 | 29481436 | No |
| 1861 | 1727 | 1727.0 | 46.4 | 46.4 | Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. | G C Walker | Microbiol Rev | 1984 | 6371470 | No |
| 1862 | 1726 | 1726.0 | 37.7 | 37.7 | Neuronal calcium signaling. | M J Berridge | Neuron | 1998 | 9697848 | No |
| 1863 | 6904 | 1726.0 | 355.0 | 88.8 | Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads. | Ryan R Wick, Louise M Judd, Claire L Gorrie, Kathryn E Holt | PLoS Comput Biol | 2017 | 28594827 | Yes |
| 1864 | 1725 | 1725.0 | 68.5 | 68.5 | An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. | J Kabat-Zinn | Gen Hosp Psychiatry | 1982 | 7042457 | Yes |
| 1865 | 1725 | 1725.0 | 43.8 | 43.8 | Recognition of errors in three-dimensional structures of proteins. | M J Sippl | Proteins | 1993 | 8108378 | Yes |
| 1866 | 1725 | 1725.0 | 34.5 | 34.5 | Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. | R K Jain | Nat Med | 2001 | 11533692 | No |
| 1867 | 1724 | 1724.0 | 51.0 | 51.0 | Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. | E N Bergman | Physiol Rev | 1990 | 2181501 | No |
| 1868 | 1724 | 1724.0 | 39.6 | 39.6 | Pedigrees of some mutant strains of Escherichia coli K-12. | B J Bachmann | Bacteriol Rev | 1972 | 4568763 | No |
| 1869 | 1723 | 1723.0 | 92.4 | 92.4 | Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. | F E Zajac | Crit Rev Biomed Eng | 1989 | 2676342 | No |
| 1870 | 5166 | 1722.0 | 216.2 | 72.1 | Some statistical methods useful in circulation research. | S Wallenstein, C L Zucker, J L Fleiss | Circ Res | 1980 | 7379260 | Yes |
| 1871 | 10329 | 1721.5 | 249.3 | 41.6 | Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. | Hadi Valadi, Karin Ekstrom, Apostolos Bossios, Margareta Sjostrand, James J Lee, Jan O Lotvall | Nat Cell Biol | 2007 | 17486113 | Yes |
| 1872 | 1721 | 1721.0 | 64.6 | 64.6 | Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. | K O Fagerstrom | Addict Behav | 1978 | 735910 | Yes |
| 1873 | 1721 | 1721.0 | 42.4 | 42.4 | Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. | S C Manolagas | Endocr Rev | 2000 | 10782361 | No |
| 1874 | 5160 | 1720.0 | 106.0 | 35.3 | T-Coffee: A novel method for fast and accurate multiple sequence alignment. | C Notredame, D G Higgins, J Heringa | J Mol Biol | 2000 | 10964570 | Yes |
| 1875 | 3440 | 1720.0 | 76.7 | 38.4 | Microtubules as a target for anticancer drugs. | Mary Ann Jordan, Leslie Wilson | Nat Rev Cancer | 2004 | 15057285 | No |
| 1876 | 1719 | 1719.0 | 0.0 | 0.0 | Carbonic anhydrase: chemistry, physiology, and inhibition. | T H Maren | Physiol Rev | 1967 | 4964060 | No |
| 1877 | 3435 | 1717.5 | 71.1 | 35.5 | Upstream and downstream of mTOR. | Nissim Hay, Nahum Sonenberg | Genes Dev | 2004 | 15314020 | No |
| 1878 | 1717 | 1717.0 | 40.9 | 40.9 | The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. | R Ross | J Cell Biol | 1971 | 4327464 | Yes |
| 1879 | 1717 | 1717.0 | 34.0 | 34.0 | Hox genes in vertebrate development. | R Krumlauf | Cell | 1994 | 7913880 | No |
| 1880 | 1716 | 1716.0 | 0.0 | 0.0 | Application of a Theory of Enzyme Specificity to Protein Synthesis. | D E Koshland | Proc Natl Acad Sci U S A | 1958 | 16590179 | Yes |
| 1881 | 1716 | 1716.0 | 43.6 | 43.6 | Reconciling the chemistry and biology of reactive oxygen species. | Christine C Winterbourn | Nat Chem Biol | 2008 | 18421291 | No |
| 1882 | 1716 | 1716.0 | 64.2 | 64.2 | Microtiter dish biofilm formation assay. | George A O'Toole | J Vis Exp | 2011 | 21307833 | Yes |
| 1883 | 1716 | 1716.0 | 53.5 | 53.5 | Inflammation in atherosclerosis. | Peter Libby | Arterioscler Thromb Vasc Biol | 2012 | 22895665 | No |
| 1884 | 1715 | 1715.0 | 36.8 | 36.8 | Tumor metastasis: mechanistic insights and clinical challenges. | Patricia S Steeg | Nat Med | 2006 | 16892035 | No |
| 1885 | 6855 | 1713.8 | 157.4 | 39.4 | Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. | E A Jaffe, R L Nachman, C G Becker, C R Minick | J Clin Invest | 1973 | 4355998 | Yes |
| 1886 | 3427 | 1713.5 | 109.3 | 54.6 | Porosity of 3D biomaterial scaffolds and osteogenesis. | Vassilis Karageorgiou, David Kaplan | Biomaterials | 2005 | 15860204 | No |
| 1887 | 1713 | 1713.0 | 49.9 | 49.9 | Gold-catalyzed organic reactions. | A Stephen K Hashmi | Chem Rev | 2007 | 17580975 | Yes |
| 1888 | 1713 | 1713.0 | 48.7 | 48.7 | Subcutaneous and visceral adipose tissue: structural and functional differences. | M Mohsen Ibrahim | Obes Rev | 2010 | 19656312 | No |
| 1889 | 3423 | 1711.5 | 81.5 | 40.8 | The human plasma proteome: history, character, and diagnostic prospects. | N Leigh Anderson, Norman G Anderson | Mol Cell Proteomics | 2002 | 12488461 | No |
| 1890 | 3422 | 1711.0 | 0.0 | 0.0 | A "Direct-Coloring" Thiocholine Method For Cholinesterases. | M J Karnovsky, L Roots | J Histochem Cytochem | 1964 | 14187330 | Yes |
| 1891 | 3421 | 1710.5 | 102.8 | 51.4 | Diarrheagenic Escherichia coli. | J P Nataro, J B Kaper | Clin Microbiol Rev | 1998 | 9457432 | No |
| 1892 | 1710 | 1710.0 | 61.3 | 61.3 | Number of people with glaucoma worldwide. | H A Quigley | Br J Ophthalmol | 1996 | 8695555 | No |
| 1893 | 3418 | 1709.0 | 81.9 | 41.0 | Human mesenchymal stem cells modulate allogeneic immune cell responses. | Sudeepta Aggarwal, Mark F Pittenger | Blood | 2005 | 15494428 | Yes |
| 1894 | 6836 | 1709.0 | 234.0 | 58.5 | The chemistry and applications of metal-organic frameworks. | Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M Yaghi | Science | 2013 | 23990564 | Yes |
| 1895 | 3417 | 1708.5 | 103.3 | 51.6 | Unified approach for molecular dynamics and density-functional theory. | R Car, M Parrinello | Phys Rev Lett | 1985 | 10032153 | Yes |
| 1896 | 1708 | 1708.0 | 50.1 | 50.1 | Nanobodies: natural single-domain antibodies. | Serge Muyldermans | Annu Rev Biochem | 2013 | 23495938 | No |
| 1897 | 3416 | 1708.0 | 128.4 | 64.2 | Macrophages in Tissue Repair, Regeneration, and Fibrosis. | Thomas A Wynn, Kevin M Vannella | Immunity | 2016 | 26982353 | No |
| 1898 | 3415 | 1707.5 | 113.8 | 56.9 | Physiological time-series analysis using approximate entropy and sample entropy. | J S Richman, J R Moorman | Am J Physiol Heart Circ Physiol | 2000 | 10843903 | Yes |
| 1899 | 10243 | 1707.2 | 242.5 | 40.4 | Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. | D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire | Science | 1987 | 3798106 | Yes |
| 1900 | 3414 | 1707.0 | 90.2 | 45.1 | The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. | A E Bolton, W M Hunter | Biochem J | 1973 | 4733239 | Yes |
| 1901 | 3414 | 1707.0 | 86.3 | 43.1 | Protein structure prediction on the Web: a case study using the Phyre server. | Lawrence A Kelley, Michael J E Sternberg | Nat Protoc | 2009 | 19247286 | Yes |
| 1902 | 3413 | 1706.5 | 99.3 | 49.6 | A fast, lock-free approach for efficient parallel counting of occurrences of k-mers. | Guillaume Marcais, Carl Kingsford | Bioinformatics | 2011 | 21217122 | Yes |
| 1903 | 1706 | 1706.0 | 45.7 | 45.7 | Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. | D A Dougherty | Science | 1996 | 8539615 | No |
| 1904 | 3412 | 1706.0 | 105.6 | 52.8 | What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. | J Zhang, K F Yu | JAMA | 1998 | 9832001 | Yes |
| 1905 | 1706 | 1706.0 | 33.3 | 33.3 | Protein kinases--the major drug targets of the twenty-first century? | Philip Cohen | Nat Rev Drug Discov | 2002 | 12120282 | No |
| 1906 | 1705 | 1705.0 | 33.5 | 33.5 | Switching and signaling at the telomere. | E H Blackburn | Cell | 2001 | 11572773 | No |
| 1907 | 3410 | 1705.0 | 88.3 | 44.1 | Lipid rafts as a membrane-organizing principle. | Daniel Lingwood, Kai Simons | Science | 2010 | 20044567 | No |
| 1908 | 3409 | 1704.5 | 112.6 | 56.3 | MissForest--non-parametric missing value imputation for mixed-type data. | Daniel J Stekhoven, Peter Buhlmann | Bioinformatics | 2012 | 22039212 | Yes |
| 1909 | 1704 | 1704.0 | 51.5 | 51.5 | Classification of inflammatory bowel disease. | J E Lennard-Jones | Scand J Gastroenterol Suppl | 1989 | 2617184 | Yes |
| 1910 | 1704 | 1704.0 | 0.0 | 0.0 | The statistical analysis of enzyme kinetic data. | W W Cleland | Adv Enzymol Relat Areas Mol Biol | 1967 | 4881884 | No |
| 1911 | 1704 | 1704.0 | 40.0 | 40.0 | Insulin and insulin-like growth factor signalling in neoplasia. | Michael Pollak | Nat Rev Cancer | 2008 | 19029956 | No |
| 1912 | 3407 | 1703.5 | 117.0 | 58.5 | Factors affecting wound healing. | S Guo, L A Dipietro | J Dent Res | 2010 | 20139336 | No |
| 1913 | 5110 | 1703.3 | 186.6 | 62.2 | CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. | Teresa C Horan, Mary Andrus, Margaret A Dudeck | Am J Infect Control | 2008 | 18538699 | No |
| 1914 | 1703 | 1703.0 | 41.9 | 41.9 | Upconversion and anti-Stokes processes with f and d ions in solids. | Francois Auzel | Chem Rev | 2004 | 14719973 | Yes |
| 1915 | 3405 | 1702.5 | 82.5 | 41.2 | The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. | P Angel, M Karin | Biochim Biophys Acta | 1991 | 1751545 | No |
| 1916 | 1702 | 1702.0 | 55.1 | 55.1 | Aging, natural death, and the compression of morbidity. | J F Fries | N Engl J Med | 1980 | 7383070 | Yes |
| 1917 | 1702 | 1702.0 | 0.0 | 0.0 | Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. | E G Gray | J Anat | 1959 | 13829103 | Yes |
| 1918 | 3404 | 1702.0 | 123.0 | 61.5 | How useful is SBF in predicting in vivo bone bioactivity? | Tadashi Kokubo, Hiroaki Takadama | Biomaterials | 2006 | 16448693 | No |
| 1919 | 1702 | 1702.0 | 43.0 | 43.0 | Use and misuse of the receiver operating characteristic curve in risk prediction. | Nancy R Cook | Circulation | 2007 | 17309939 | Yes |
| 1920 | 1701 | 1701.0 | 57.4 | 57.4 | The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. | J L Cummings | Neurology | 1997 | 9153155 | No |
| 1921 | 1701 | 1701.0 | 34.9 | 34.9 | Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. | D I Svergun | Biophys J | 1999 | 10354416 | Yes |
| 1922 | 3402 | 1701.0 | 164.9 | 82.5 | Breast Cancer Treatment: A Review. | Adrienne G Waks, Eric P Winer | JAMA | 2019 | 30667505 | No |
| 1923 | 10205 | 1700.8 | 360.0 | 60.0 | Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. | L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum | Anal Biochem | 1982 | 7181105 | Yes |
| 1924 | 3399 | 1699.5 | 116.8 | 58.4 | Role of free radicals and catalytic metal ions in human disease: an overview. | B Halliwell, J M Gutteridge | Methods Enzymol | 1990 | 2172697 | No |
| 1925 | 1698 | 1698.0 | 42.1 | 42.1 | NADPH oxidase: an update. | B M Babior | Blood | 1999 | 10029572 | No |
| 1926 | 1698 | 1698.0 | 53.1 | 53.1 | Synopsis of some recent tactical application of bioisosteres in drug design. | Nicholas A Meanwell | J Med Chem | 2011 | 21413808 | Yes |
| 1927 | 5093 | 1697.7 | 142.6 | 47.5 | Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. | B Fischl, M I Sereno, A M Dale | Neuroimage | 1999 | 9931269 | Yes |
| 1928 | 1697 | 1697.0 | 0.0 | 0.0 | A graphic method for the determination and presentation of binding parameters in a complex system. | H E Rosenthal | Anal Biochem | 1967 | 6048188 | Yes |
| 1929 | 1697 | 1697.0 | 56.2 | 56.2 | Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. | L Bravo | Nutr Rev | 1998 | 9838798 | No |
| 1930 | 5089 | 1696.3 | 115.4 | 38.5 | Osteoclast differentiation and activation. | William J Boyle, W Scott Simonet, David L Lacey | Nature | 2003 | 12748652 | No |
| 1931 | 1696 | 1696.0 | 46.1 | 46.1 | Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. | M J Meaney | Annu Rev Neurosci | 2001 | 11520931 | No |
| 1932 | 1695 | 1695.0 | 29.8 | 29.8 | RNA-dependent DNA polymerase in virions of RNA tumour viruses. | D Baltimore | Nature | 1970 | 4316300 | Yes |
| 1933 | 1693 | 1693.0 | 0.0 | 0.0 | Plastic Embedding Mixtures For Use In Electron Microscopy. | H H Mollenhauer | Stain Technol | 1964 | 14127791 | Yes |
| 1934 | 1692 | 1692.0 | 47.1 | 47.1 | Integrins. | E Ruoslahti | J Clin Invest | 1991 | 1985087 | No |
| 1935 | 3384 | 1692.0 | 98.1 | 49.0 | Biochemistry of multidrug resistance mediated by the multidrug transporter. | M M Gottesman, I Pastan | Annu Rev Biochem | 1993 | 8102521 | No |
| 1936 | 1692 | 1692.0 | 36.7 | 36.7 | Sustainable hydrogen production. | John A Turner | Science | 2004 | 15310892 | Yes |
| 1937 | 1692 | 1692.0 | 44.7 | 44.7 | Fast and robust fixed-point algorithms for independent component analysis. | A Hyvarinen | IEEE Trans Neural Netw | 1999 | 18252563 | Yes |
| 1938 | 5075 | 1691.7 | 144.3 | 48.1 | Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. | M Hasegawa, H Kishino, T Yano | J Mol Evol | 1985 | 3934395 | Yes |
| 1939 | 1691 | 1691.0 | 45.7 | 45.7 | Alpha-crystallin can function as a molecular chaperone. | J Horwitz | Proc Natl Acad Sci U S A | 1992 | 1438232 | Yes |
| 1940 | 1691 | 1691.0 | 76.1 | 76.1 | Mood and memory. | G H Bower | Am Psychol | 1981 | 7224324 | Yes |
| 1941 | 1691 | 1691.0 | 34.5 | 34.5 | Macromolecular crowding: obvious but underappreciated. | R J Ellis | Trends Biochem Sci | 2001 | 11590012 | No |
| 1942 | 1691 | 1691.0 | 38.0 | 38.0 | Mechanisms of bone metastasis. | G David Roodman | N Engl J Med | 2004 | 15084698 | No |
| 1943 | 1690 | 1690.0 | 55.5 | 55.5 | Metallothionein. | D H Hamer | Annu Rev Biochem | 1986 | 3527054 | No |
| 1944 | 1690 | 1690.0 | 60.1 | 60.1 | Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. | A H Conney | Cancer Res | 1982 | 6814745 | No |
| 1945 | 3379 | 1689.5 | 109.6 | 54.8 | An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. | O Johnell, J A Kanis | Osteoporos Int | 2006 | 16983459 | Yes |
| 1946 | 1689 | 1689.0 | 41.7 | 41.7 | The molecular genetics of cancer. | J M Bishop | Science | 1987 | 3541204 | No |
| 1947 | 1688 | 1688.0 | 66.7 | 66.7 | A structured interview guide for the Hamilton Depression Rating Scale. | J B Williams | Arch Gen Psychiatry | 1988 | 3395203 | Yes |
| 1948 | 6750 | 1687.5 | 169.1 | 42.3 | Most mammalian mRNAs are conserved targets of microRNAs. | Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel | Genome Res | 2009 | 18955434 | Yes |
| 1949 | 5058 | 1686.0 | 147.0 | 49.0 | How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. | R M Sapolsky, L M Romero, A U Munck | Endocr Rev | 2000 | 10696570 | No |
| 1950 | 8429 | 1685.8 | 439.2 | 87.8 | Standards for reporting qualitative research: a synthesis of recommendations. | Bridget C O'Brien, Ilene B Harris, Thomas J Beckman, Darcy A Reed, David A Cook | Acad Med | 2014 | 24979285 | Yes |
| 1951 | 3370 | 1685.0 | 125.7 | 62.9 | Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. | D B Dill, D L Costill | J Appl Physiol | 1974 | 4850854 | Yes |
| 1952 | 1685 | 1685.0 | 41.2 | 41.2 | A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. | D A Gewirtz | Biochem Pharmacol | 1999 | 10075079 | No |
| 1953 | 3369 | 1684.5 | 106.5 | 53.2 | Palladium-catalyzed ligand-directed C-H functionalization reactions. | Thomas W Lyons, Melanie S Sanford | Chem Rev | 2010 | 20078038 | No |
| 1954 | 1684 | 1684.0 | 39.7 | 39.7 | The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. | D M Kingsley | Genes Dev | 1994 | 8299934 | No |
| 1955 | 8413 | 1682.6 | 331.8 | 66.4 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | Int J Surg | 2010 | 20171303 | No |
| 1956 | 1682 | 1682.0 | 32.7 | 32.7 | Cell cycle checkpoints: preventing an identity crisis. | S J Elledge | Science | 1996 | 8939848 | No |
| 1957 | 1682 | 1682.0 | 0.0 | 0.0 | Chromatographic Separation Of Human Brain Gangliosides. | L Svennerholm | J Neurochem | 1963 | 14066623 | Yes |
| 1958 | 1681 | 1681.0 | 68.6 | 68.6 | Social phobia. | M R Liebowitz | Mod Probl Pharmacopsychiatry | 1987 | 2885745 | Yes |
| 1959 | 1681 | 1681.0 | 56.9 | 56.9 | Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. | J A Miller | Cancer Res | 1970 | 4915745 | No |
| 1960 | 1679 | 1679.0 | 64.1 | 64.1 | The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. | Poul Erik Petersen | Community Dent Oral Epidemiol | 2003 | 15015736 | Yes |
| 1961 | 3355 | 1677.5 | 69.0 | 34.5 | NF-kappaB regulation in the immune system. | Qiutang Li, Inder M Verma | Nat Rev Immunol | 2002 | 12360211 | No |
| 1962 | 3353 | 1676.5 | 80.3 | 40.1 | NF-kappaB: a key role in inflammatory diseases. | P P Tak, G S Firestein | J Clin Invest | 2001 | 11134171 | No |
| 1963 | 1676 | 1676.0 | 54.2 | 54.2 | Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). | G G Glenner | N Engl J Med | 1980 | 6154243 | No |
| 1964 | 1676 | 1676.0 | 83.0 | 83.0 | Non-alcoholic fatty liver disease - A global public health perspective. | Zobair M Younossi | J Hepatol | 2019 | 30414863 | No |
| 1965 | 5027 | 1675.7 | 123.4 | 41.1 | Two-photon laser scanning fluorescence microscopy. | W Denk, J H Strickler, W W Webb | Science | 1990 | 2321027 | Yes |
| 1966 | 11727 | 1675.3 | 401.5 | 57.4 | Metagenomic biomarker discovery and explanation. | Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis Huttenhower | Genome Biol | 2011 | 21702898 | Yes |
| 1967 | 1675 | 1675.0 | 0.0 | 0.0 | The generalisation of student's problems when several different population variances are involved. | B L Welch | Biometrika | 1947 | 20287819 | Yes |
| 1968 | 1673 | 1673.0 | 54.0 | 54.0 | The role of the amygdala in fear and anxiety. | M Davis | Annu Rev Neurosci | 1992 | 1575447 | No |
| 1969 | 1673 | 1673.0 | 44.1 | 44.1 | Neurotrophins and neuronal plasticity. | H Thoenen | Science | 1995 | 7570017 | No |
| 1970 | 1673 | 1673.0 | 47.2 | 47.2 | Sarcopenia: origins and clinical relevance. | I H Rosenberg | J Nutr | 1997 | 9164280 | No |
| 1971 | 3345 | 1672.5 | 73.5 | 36.8 | Cancer metastasis: building a framework. | Gaorav P Gupta, Joan Massague | Cell | 2006 | 17110329 | No |
| 1972 | 1672 | 1672.0 | 56.0 | 56.0 | Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). | M N Marsh | Gastroenterology | 1992 | 1727768 | No |
| 1973 | 1672 | 1672.0 | 33.2 | 33.2 | The microRNA Registry. | Sam Griffiths-Jones | Nucleic Acids Res | 2004 | 14681370 | Yes |
| 1974 | 3343 | 1671.5 | 120.1 | 60.0 | The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. | Julie D Henry, John R Crawford | Br J Clin Psychol | 2005 | 16004657 | Yes |
| 1975 | 3343 | 1671.5 | 85.1 | 42.5 | Alternative activation of macrophages: mechanism and functions. | Siamon Gordon, Fernando O Martinez | Immunity | 2010 | 20510870 | No |
| 1976 | 1671 | 1671.0 | 42.1 | 42.1 | Myeloperoxidase: friend and foe. | Seymour J Klebanoff | J Leukoc Biol | 2005 | 15689384 | No |
| 1977 | 1671 | 1671.0 | 56.9 | 56.9 | The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. | Eleonore Frohlich | Int J Nanomedicine | 2012 | 23144561 | No |
| 1978 | 5009 | 1669.7 | 165.1 | 55.0 | Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. | Marina Colombo, Graca Raposo, Clotilde Thery | Annu Rev Cell Dev Biol | 2014 | 25288114 | No |
| 1979 | 1669 | 1669.0 | 47.0 | 47.0 | Aspergillus fumigatus and aspergillosis. | J P Latge | Clin Microbiol Rev | 1999 | 10194462 | No |
| 1980 | 1669 | 1669.0 | 40.4 | 40.4 | Hypertrophic cardiomyopathy: a systematic review. | Barry J Maron | JAMA | 2002 | 11886323 | Yes |
| 1981 | 5007 | 1669.0 | 102.6 | 34.2 | The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. | Fabio Martinon, Kimberly Burns, Jurg Tschopp | Mol Cell | 2002 | 12191486 | Yes |
| 1982 | 1669 | 1669.0 | 0.0 | 0.0 | Method for the determination of hexosamines in tissues. | N F Boas | J Biol Chem | 1953 | 13117829 | Yes |
| 1983 | 3338 | 1669.0 | 71.0 | 35.5 | Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. | E Krissinel, K Henrick | Acta Crystallogr D Biol Crystallogr | 2004 | 15572779 | Yes |
| 1984 | 3338 | 1669.0 | 131.1 | 65.5 | Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. | Peter C Austin, Elizabeth A Stuart | Stat Med | 2015 | 26238958 | Yes |
| 1985 | 3337 | 1668.5 | 0.0 | 0.0 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. | T Omura, R Sato | J Biol Chem | 1964 | 14209972 | Yes |
| 1986 | 13347 | 1668.4 | 353.9 | 44.2 | Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. | William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan, | N Engl J Med | 2002 | 11832527 | Yes |
| 1987 | 1668 | 1668.0 | 50.7 | 50.7 | The role of autophagy in neurodegenerative disease. | Ralph A Nixon | Nat Med | 2013 | 23921753 | No |
| 1988 | 1667 | 1667.0 | 41.4 | 41.4 | Getting formal with dopamine and reward. | Wolfram Schultz | Neuron | 2002 | 12383780 | No |
| 1989 | 1667 | 1667.0 | 49.9 | 49.9 | Bioactive microbial metabolites. | Janos Berdy | J Antibiot (Tokyo) | 2005 | 15813176 | No |
| 1990 | 3334 | 1667.0 | 80.7 | 40.4 | Malignant gliomas in adults. | Patrick Y Wen, Santosh Kesari | N Engl J Med | 2008 | 18669428 | No |
| 1991 | 1666 | 1666.0 | 62.2 | 62.2 | Frontal-subcortical circuits and human behavior. | J L Cummings | Arch Neurol | 1993 | 8352676 | No |
| 1992 | 3332 | 1666.0 | 114.7 | 57.4 | A new initiative on precision medicine. | Francis S Collins, Harold Varmus | N Engl J Med | 2015 | 25635347 | Yes |
| 1993 | 3331 | 1665.5 | 139.7 | 69.8 | AMPK: guardian of metabolism and mitochondrial homeostasis. | Sebastien Herzig, Reuben J Shaw | Nat Rev Mol Cell Biol | 2018 | 28974774 | No |
| 1994 | 4996 | 1665.3 | 0.0 | 0.0 | Improved method for the determination of blood glutathione. | E Beutler, O Duron, B M Kelly | J Lab Clin Med | 1963 | 13967893 | Yes |
| 1995 | 3330 | 1665.0 | 72.9 | 36.5 | Coordination of circadian timing in mammals. | Steven M Reppert, David R Weaver | Nature | 2002 | 12198538 | No |
| 1996 | 3330 | 1665.0 | 139.1 | 69.5 | The content validity index: are you sure you know what's being reported? Critique and recommendations. | Denise F Polit, Cheryl Tatano Beck | Res Nurs Health | 2006 | 16977646 | Yes |
| 1997 | 3329 | 1664.5 | 73.7 | 36.9 | Protein structure comparison by alignment of distance matrices. | L Holm, C Sander | J Mol Biol | 1993 | 8377180 | Yes |
| 1998 | 1664 | 1664.0 | 57.6 | 57.6 | Archaea in coastal marine environments. | E F DeLong | Proc Natl Acad Sci U S A | 1992 | 1608980 | Yes |
| 1999 | 3328 | 1664.0 | 0.0 | 0.0 | Method for the isolation of intact islets of Langerhans from the rat pancreas. | P E Lacy, M Kostianovsky | Diabetes | 1967 | 5333500 | Yes |
| 2000 | 1664 | 1664.0 | 56.5 | 56.5 | Evaluating the quality of medical care. 1966. | Avedis Donabedian | Milbank Q | 2005 | 16279964 | No |
| 2001 | 3328 | 1664.0 | 90.0 | 45.0 | Materials for electrochemical capacitors. | Patrice Simon, Yury Gogotsi | Nat Mater | 2008 | 18956000 | Yes |
| 2002 | 3326 | 1663.0 | 63.1 | 31.6 | The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. | Michael H Glickman, Aaron Ciechanover | Physiol Rev | 2002 | 11917093 | No |
| 2003 | 1663 | 1663.0 | 48.5 | 48.5 | n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. | Philip C Calder | Am J Clin Nutr | 2006 | 16841861 | No |
| 2004 | 1663 | 1663.0 | 34.3 | 34.3 | The Buccaneer software for automated model building. 1. Tracing protein chains. | Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2006 | 16929101 | Yes |
| 2005 | 3324 | 1662.0 | 92.6 | 46.3 | A globally coherent fingerprint of climate change impacts across natural systems. | Camille Parmesan, Gary Yohe | Nature | 2003 | 12511946 | Yes |
| 2006 | 3323 | 1661.5 | 78.7 | 39.4 | A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. | L Buck, R Axel | Cell | 1991 | 1840504 | Yes |
| 2007 | 3323 | 1661.5 | 112.5 | 56.2 | Mediation in experimental and nonexperimental studies: new procedures and recommendations. | Patrick E Shrout, Niall Bolger | Psychol Methods | 2002 | 12530702 | Yes |
| 2008 | 1661 | 1661.0 | 71.5 | 71.5 | Drugs which inhibit prostaglandin biosynthesis. | R J Flower | Pharmacol Rev | 1974 | 4208101 | Yes |
| 2009 | 3322 | 1661.0 | 84.3 | 42.1 | Steatohepatitis: a tale of two "hits"? | C P Day, O F James | Gastroenterology | 1998 | 9547102 | No |
| 2010 | 1661 | 1661.0 | 38.3 | 38.3 | From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. | W A Catterall | Neuron | 2000 | 10798388 | No |
| 2011 | 1661 | 1661.0 | 32.2 | 32.2 | Protein degradation and protection against misfolded or damaged proteins. | Alfred L Goldberg | Nature | 2003 | 14685250 | No |
| 2012 | 6642 | 1660.5 | 299.9 | 75.0 | Progressive statistics for studies in sports medicine and exercise science. | William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri Hanin | Med Sci Sports Exerc | 2009 | 19092709 | No |
| 2013 | 1660 | 1660.0 | 0.0 | 0.0 | An improved procedure for serum creatine phosphokinase determination. | S B Rosalki | J Lab Clin Med | 1967 | 4381359 | Yes |
| 2014 | 1660 | 1660.0 | 45.0 | 45.0 | The corticosteroid receptor hypothesis of depression. | F Holsboer | Neuropsychopharmacology | 2000 | 11027914 | No |
| 2015 | 1660 | 1660.0 | 0.0 | 0.0 | The theory and applications of the exchange of inert gas at the lungs and tissues. | S S Kety | Pharmacol Rev | 1951 | 14833874 | Yes |
| 2016 | 6637 | 1659.2 | 155.3 | 38.8 | Use of T7 RNA polymerase to direct expression of cloned genes. | F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff | Methods Enzymol | 1990 | 2199796 | Yes |
| 2017 | 3316 | 1658.0 | 154.4 | 77.2 | A scaled version of the General Health Questionnaire. | D P Goldberg, V F Hillier | Psychol Med | 1979 | 424481 | Yes |
| 2018 | 1658 | 1658.0 | 28.1 | 28.1 | Selforganization of matter and the evolution of biological macromolecules. | M Eigen | Naturwissenschaften | 1971 | 4942363 | No |
| 2019 | 1658 | 1658.0 | 58.4 | 58.4 | Phase retrieval algorithms: a comparison. | J R Fienup | Appl Opt | 1982 | 20396114 | Yes |
| 2020 | 3315 | 1657.5 | 80.5 | 40.2 | Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. | M Grunstein, D S Hogness | Proc Natl Acad Sci U S A | 1975 | 1105573 | Yes |
| 2021 | 1657 | 1657.0 | 63.9 | 63.9 | SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. | B P O'Connor | Behav Res Methods Instrum Comput | 2000 | 11029811 | Yes |
| 2022 | 1657 | 1657.0 | 40.4 | 40.4 | Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. | Christopher Paul Wild | Cancer Epidemiol Biomarkers Prev | 2005 | 16103423 | No |
| 2023 | 3314 | 1657.0 | 68.2 | 34.1 | Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. | Joshua E Elias, Steven P Gygi | Nat Methods | 2007 | 17327847 | Yes |
| 2024 | 1656 | 1656.0 | 66.0 | 66.0 | What is self-rated health and why does it predict mortality? Towards a unified conceptual model. | Marja Jylha | Soc Sci Med | 2009 | 19520474 | Yes |
| 2025 | 1655 | 1655.0 | 0.0 | 0.0 | Structural considerations in the interaction of DNA and acridines. | L S Lerman | J Mol Biol | 1961 | 13761054 | Yes |
| 2026 | 4965 | 1655.0 | 156.3 | 52.1 | The Patient Health Questionnaire-2: validity of a two-item depression screener. | Kurt Kroenke, Robert L Spitzer, Janet B W Williams | Med Care | 2003 | 14583691 | Yes |
| 2027 | 1655 | 1655.0 | 36.3 | 36.3 | DNA damage, aging, and cancer. | Jan H J Hoeijmakers | N Engl J Med | 2009 | 19812404 | No |
| 2028 | 6619 | 1654.8 | 242.2 | 60.5 | MultiQC: summarize analysis results for multiple tools and samples in a single report. | Philip Ewels, Mans Magnusson, Sverker Lundin, Max Kaller | Bioinformatics | 2016 | 27312411 | Yes |
| 2029 | 1654 | 1654.0 | 42.2 | 42.2 | The 'effective number of codons' used in a gene. | F Wright | Gene | 1990 | 2110097 | Yes |
| 2030 | 1654 | 1654.0 | 58.7 | 58.7 | Glutathione synthesis. | Shelly C Lu | Biochim Biophys Acta | 2013 | 22995213 | No |
| 2031 | 1653 | 1653.0 | 75.6 | 75.6 | The contribution of low birth weight to infant mortality and childhood morbidity. | M C McCormick | N Engl J Med | 1985 | 3880598 | No |
| 2032 | 1653 | 1653.0 | 31.1 | 31.1 | Vienna RNA secondary structure server. | Ivo L Hofacker | Nucleic Acids Res | 2003 | 12824340 | Yes |
| 2033 | 1653 | 1653.0 | 80.4 | 80.4 | Statistical notes for clinical researchers: assessing normal distribution (2) using skewness and kurtosis. | Hae-Young Kim | Restor Dent Endod | 2013 | 23495371 | Yes |
| 2034 | 3305 | 1652.5 | 100.1 | 50.0 | Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. | M Karas, F Hillenkamp | Anal Chem | 1988 | 3239801 | Yes |
| 2035 | 1652 | 1652.0 | 55.4 | 55.4 | Interhemispheric differences in the localization of psychological processes in man. | B Milner | Br Med Bull | 1971 | 4937273 | No |
| 2036 | 1652 | 1652.0 | 36.1 | 36.1 | Bone morphogenetic proteins: multifunctional regulators of vertebrate development. | B L Hogan | Genes Dev | 1996 | 8682290 | No |
| 2037 | 1652 | 1652.0 | 31.5 | 31.5 | Immunosuppressive networks in the tumour environment and their therapeutic relevance. | Weiping Zou | Nat Rev Cancer | 2005 | 15776005 | No |
| 2038 | 3303 | 1651.5 | 87.8 | 43.9 | Genome regulation by long noncoding RNAs. | John L Rinn, Howard Y Chang | Annu Rev Biochem | 2012 | 22663078 | No |
| 2039 | 1651 | 1651.0 | 36.4 | 36.4 | Fluorescence energy transfer as a spectroscopic ruler. | L Stryer | Annu Rev Biochem | 1978 | 354506 | No |
| 2040 | 6604 | 1651.0 | 166.7 | 41.7 | Universal sample preparation method for proteome analysis. | Jacek R Wisniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias Mann | Nat Methods | 2009 | 19377485 | Yes |
| 2041 | 1650 | 1650.0 | 29.2 | 29.2 | Cell cycle checkpoint signaling through the ATM and ATR kinases. | R T Abraham | Genes Dev | 2001 | 11544175 | No |
| 2042 | 1650 | 1650.0 | 91.9 | 91.9 | Head and Neck Cancer. | Laura Q M Chow | N Engl J Med | 2020 | 31893516 | No |
| 2043 | 3299 | 1649.5 | 108.1 | 54.0 | Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. | Sarah E Barlow, | Pediatrics | 2007 | 18055651 | Yes |
| 2044 | 1649 | 1649.0 | 34.3 | 34.3 | Structural features in eukaryotic mRNAs that modulate the initiation of translation. | M Kozak | J Biol Chem | 1991 | 1939050 | No |
| 2045 | 3298 | 1649.0 | 83.8 | 41.9 | Molecular replacement with MOLREP. | Alexei Vagin, Alexei Teplyakov | Acta Crystallogr D Biol Crystallogr | 2010 | 20057045 | Yes |
| 2046 | 1648 | 1648.0 | 42.1 | 42.1 | Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. | C A Barnes | J Comp Physiol Psychol | 1979 | 221551 | Yes |
| 2047 | 1648 | 1648.0 | 45.0 | 45.0 | Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. | B Hille | J Gen Physiol | 1977 | 300786 | Yes |
| 2048 | 1648 | 1648.0 | 38.1 | 38.1 | Measuring information transfer | T Schreiber | Phys Rev Lett | 2000 | 10991308 | Yes |
| 2049 | 1647 | 1647.0 | 34.1 | 34.1 | RNA silencing in plants. | David Baulcombe | Nature | 2004 | 15372043 | No |
| 2050 | 9878 | 1646.3 | 355.6 | 59.3 | StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. | Mihaela Pertea, Geo M Pertea, Corina M Antonescu, Tsung-Cheng Chang, Joshua T Mendell, Steven L Salzberg | Nat Biotechnol | 2015 | 25690850 | Yes |
| 2051 | 1646 | 1646.0 | 42.1 | 42.1 | Inflammatory bowel disease: etiology and pathogenesis. | C Fiocchi | Gastroenterology | 1998 | 9649475 | No |
| 2052 | 1646 | 1646.0 | 41.3 | 41.3 | The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. | H Maeda | Adv Enzyme Regul | 2001 | 11384745 | No |
| 2053 | 1645 | 1645.0 | 50.4 | 50.4 | Extracellular ATP: effects, sources and fate. | J L Gordon | Biochem J | 1986 | 3006665 | No |
| 2054 | 1644 | 1644.0 | 32.1 | 32.1 | Intrinsically unstructured proteins. | Peter Tompa | Trends Biochem Sci | 2002 | 12368089 | No |
| 2055 | 3288 | 1644.0 | 70.6 | 35.3 | Signaling to NF-kappaB. | Matthew S Hayden, Sankar Ghosh | Genes Dev | 2004 | 15371334 | No |
| 2056 | 1644 | 1644.0 | 32.3 | 32.3 | Regulatory T cells, tumour immunity and immunotherapy. | Weiping Zou | Nat Rev Immunol | 2006 | 16557261 | No |
| 2057 | 3288 | 1644.0 | 87.2 | 43.6 | Abdominal obesity and metabolic syndrome. | Jean-Pierre Despres, Isabelle Lemieux | Nature | 2006 | 17167477 | No |
| 2058 | 1644 | 1644.0 | 41.0 | 41.0 | Mitochondrial fusion and fission in cell life and death. | Benedikt Westermann | Nat Rev Mol Cell Biol | 2010 | 21102612 | No |
| 2059 | 9863 | 1643.8 | 294.8 | 49.1 | TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. | Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg | Genome Biol | 2013 | 23618408 | Yes |
| 2060 | 1643 | 1643.0 | 45.0 | 45.0 | Precision mapping of quantitative trait loci. | Z B Zeng | Genetics | 1994 | 8013918 | Yes |
| 2061 | 4928 | 1642.7 | 151.2 | 50.4 | The fusiform face area: a module in human extrastriate cortex specialized for face perception. | N Kanwisher, J McDermott, M M Chun | J Neurosci | 1997 | 9151747 | Yes |
| 2062 | 3285 | 1642.5 | 96.4 | 48.2 | Tumor-associated macrophages: from mechanisms to therapy. | Roy Noy, Jeffrey W Pollard | Immunity | 2014 | 25035953 | No |
| 2063 | 1642 | 1642.0 | 46.9 | 46.9 | Turnover of inositol phospholipids and signal transduction. | Y Nishizuka | Science | 1984 | 6147898 | No |
| 2064 | 1642 | 1642.0 | 48.5 | 48.5 | Electrocatalyst approaches and challenges for automotive fuel cells. | Mark K Debe | Nature | 2012 | 22678278 | Yes |
| 2065 | 1641 | 1641.0 | 37.7 | 37.7 | Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. | G L Semenza | Annu Rev Cell Dev Biol | 1999 | 10611972 | No |
| 2066 | 1641 | 1641.0 | 30.5 | 30.5 | Maximum-likelihood density modification. | T C Terwilliger | Acta Crystallogr D Biol Crystallogr | 2000 | 10944333 | Yes |
| 2067 | 1641 | 1641.0 | 0.0 | 0.0 | Discharge patterns and functional organization of mammalian retina. | S W Kuffler | J Neurophysiol | 1953 | 13035466 | Yes |
| 2068 | 1640 | 1640.0 | 85.3 | 85.3 | Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. | C S Neer | J Bone Joint Surg Am | 1972 | 5054450 | Yes |
| 2069 | 13115 | 1639.4 | 364.3 | 45.5 | Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. | N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot | Neuroimage | 2002 | 11771995 | Yes |
| 2070 | 1639 | 1639.0 | 51.5 | 51.5 | Which elements are excited in electrical stimulation of mammalian central nervous system: a review. | J B Ranck | Brain Res | 1975 | 1102064 | No |
| 2071 | 3278 | 1639.0 | 107.4 | 53.7 | Origins and evolution of antibiotic resistance. | Julian Davies, Dorothy Davies | Microbiol Mol Biol Rev | 2010 | 20805405 | No |
| 2072 | 1638 | 1638.0 | 74.1 | 74.1 | Neurogenetic adaptive mechanisms in alcoholism. | C R Cloninger | Science | 1987 | 2882604 | Yes |
| 2073 | 1638 | 1638.0 | 55.2 | 55.2 | Cellular defenses against damage from reactive oxygen species. | B P Yu | Physiol Rev | 1994 | 8295932 | No |
| 2074 | 1638 | 1638.0 | 27.8 | 27.8 | Neuronal specification in the spinal cord: inductive signals and transcriptional codes. | T M Jessell | Nat Rev Genet | 2000 | 11262869 | No |
| 2075 | 1638 | 1638.0 | 39.0 | 39.0 | Thiazolidinediones. | Hannele Yki-Jarvinen | N Engl J Med | 2004 | 15356308 | No |
| 2076 | 3276 | 1638.0 | 73.0 | 36.5 | Complex networks orchestrate epithelial-mesenchymal transitions. | Jean Paul Thiery, Jonathan P Sleeman | Nat Rev Mol Cell Biol | 2006 | 16493418 | No |
| 2077 | 1637 | 1637.0 | 46.3 | 46.3 | Diversity in tropical rain forests and coral reefs. | J H Connell | Science | 1978 | 17840770 | Yes |
| 2078 | 1637 | 1637.0 | 51.1 | 51.1 | The amazing osteocyte. | Lynda F Bonewald | J Bone Miner Res | 2011 | 21254230 | No |
| 2079 | 1636 | 1636.0 | 74.6 | 74.6 | Measurement of health state utilities for economic appraisal. | G W Torrance | J Health Econ | 1986 | 10311607 | No |
| 2080 | 1636 | 1636.0 | 0.0 | 0.0 | A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. | D Mattingly | J Clin Pathol | 1962 | 14471419 | Yes |
| 2081 | 3271 | 1635.5 | 86.3 | 43.1 | Obesity. | David W Haslam, W Philip T James | Lancet | 2005 | 16198769 | No |
| 2082 | 3270 | 1635.0 | 79.1 | 39.5 | Rapid and sensitive protein similarity searches. | D J Lipman, W R Pearson | Science | 1985 | 2983426 | Yes |
| 2083 | 3270 | 1635.0 | 116.3 | 58.1 | Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. | Christoph Hafemeister, Rahul Satija | Genome Biol | 2019 | 31870423 | Yes |
| 2084 | 1634 | 1634.0 | 52.4 | 52.4 | Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. | D W Choi | Trends Neurosci | 1988 | 2469166 | No |
| 2085 | 3267 | 1633.5 | 0.0 | 0.0 | Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. | J Marmur, P Doty | J Mol Biol | 1962 | 14470099 | Yes |
| 2086 | 4898 | 1632.7 | 176.4 | 58.8 | Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. | Christopher K Prier, Danica A Rankic, David W C MacMillan | Chem Rev | 2013 | 23509883 | No |
| 2087 | 1632 | 1632.0 | 50.9 | 50.9 | The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. | Artemis P Simopoulos | Exp Biol Med (Maywood) | 2008 | 18408140 | No |
| 2088 | 3263 | 1631.5 | 82.9 | 41.5 | Dali server: conservation mapping in 3D. | Liisa Holm, Paivi Rosenstrom | Nucleic Acids Res | 2010 | 20457744 | Yes |
| 2089 | 4894 | 1631.3 | 263.8 | 87.9 | Improved metagenomic analysis with Kraken 2. | Derrick E Wood, Jennifer Lu, Ben Langmead | Genome Biol | 2019 | 31779668 | Yes |
| 2090 | 1631 | 1631.0 | 47.6 | 47.6 | The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. | R R Llinas | Science | 1988 | 3059497 | No |
| 2091 | 1631 | 1631.0 | 37.9 | 37.9 | Ordered porous materials for emerging applications. | Mark E Davis | Nature | 2002 | 12075343 | No |
| 2092 | 1631 | 1631.0 | 37.3 | 37.3 | Hyaluronan: from extracellular glue to pericellular cue. | Bryan P Toole | Nat Rev Cancer | 2004 | 15229478 | No |
| 2093 | 4892 | 1630.7 | 128.6 | 42.9 | The metabolic syndrome. | Robert H Eckel, Scott M Grundy, Paul Z Zimmet | Lancet | 2005 | 15836891 | No |
| 2094 | 1629 | 1629.0 | 47.7 | 47.7 | Ionic dependence of glutamate neurotoxicity. | D W Choi | J Neurosci | 1987 | 2880938 | Yes |
| 2095 | 3258 | 1629.0 | 55.9 | 27.9 | Mutations affecting segment number and polarity in Drosophila. | C Nusslein-Volhard, E Wieschaus | Nature | 1980 | 6776413 | Yes |
| 2096 | 3258 | 1629.0 | 69.2 | 34.6 | The Bcl2 family: regulators of the cellular life-or-death switch. | Suzanne Cory, Jerry M Adams | Nat Rev Cancer | 2002 | 12209154 | No |
| 2097 | 4883 | 1627.7 | 101.2 | 33.7 | Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). | Michael J Rust, Mark Bates, Xiaowei Zhuang | Nat Methods | 2006 | 16896339 | Yes |
| 2098 | 3255 | 1627.5 | 60.7 | 30.4 | Cellular motility driven by assembly and disassembly of actin filaments. | Thomas D Pollard, Gary G Borisy | Cell | 2003 | 12600310 | No |
| 2099 | 3255 | 1627.5 | 111.0 | 55.5 | Nitric oxide synthases: regulation and function. | Ulrich Forstermann, William C Sessa | Eur Heart J | 2012 | 21890489 | No |
| 2100 | 1626 | 1626.0 | 43.8 | 43.8 | Bacteroides: the good, the bad, and the nitty-gritty. | Hannah M Wexler | Clin Microbiol Rev | 2007 | 17934076 | No |
| 2101 | 1625 | 1625.0 | 49.4 | 49.4 | Metalloproteinases and their inhibitors in matrix remodeling. | L M Matrisian | Trends Genet | 1990 | 2132731 | No |
| 2102 | 1625 | 1625.0 | 59.1 | 59.1 | Cell damage in the brain: a speculative synthesis. | B K Siesjo | J Cereb Blood Flow Metab | 1981 | 6276420 | No |
| 2103 | 1625 | 1625.0 | 54.0 | 54.0 | The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. | G R Buettner | Arch Biochem Biophys | 1993 | 8434935 | No |
| 2104 | 1625 | 1625.0 | 0.0 | 0.0 | Dithiothreitol, A New Protective Reagent For Sh Groups. | W W Cleland | Biochemistry | 1964 | 14192894 | Yes |
| 2105 | 6496 | 1624.0 | 174.3 | 43.6 | Microbial ecology: human gut microbes associated with obesity. | Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon | Nature | 2006 | 17183309 | Yes |
| 2106 | 3247 | 1623.5 | 122.7 | 61.4 | Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. | Johan W S Vlaeyen, Steven J Linton | Pain | 2000 | 10781906 | No |
| 2107 | 3247 | 1623.5 | 133.9 | 67.0 | Using Effect Size-or Why the P Value Is Not Enough. | Gail M Sullivan, Richard Feinn | J Grad Med Educ | 2012 | 23997866 | Yes |
| 2108 | 1623 | 1623.0 | 42.3 | 42.3 | Molecular biology of prion diseases. | S B Prusiner | Science | 1991 | 1675487 | No |
| 2109 | 3246 | 1623.0 | 64.9 | 32.5 | Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. | M E Greenberg, E B Ziff | Nature | 1984 | 6090941 | Yes |
| 2110 | 4867 | 1622.3 | 131.4 | 43.8 | Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. | Earl S Ford, Wayne H Giles, William H Dietz | JAMA | 2002 | 11790215 | Yes |
| 2111 | 4867 | 1622.3 | 119.9 | 40.0 | Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. | Robert D Schreiber, Lloyd J Old, Mark J Smyth | Science | 2011 | 21436444 | No |
| 2112 | 1622 | 1622.0 | 36.0 | 36.0 | Drug discovery: a historical perspective. | J Drews | Science | 2000 | 10720314 | No |
| 2113 | 1621 | 1621.0 | 51.5 | 51.5 | Evidence for a central component of post-injury pain hypersensitivity. | C J Woolf | Nature | 1983 | 6656869 | Yes |
| 2114 | 1621 | 1621.0 | 31.5 | 31.5 | How cells read TGF-beta signals. | J Massague | Nat Rev Mol Cell Biol | 2000 | 11252892 | No |
| 2115 | 4862 | 1620.7 | 130.0 | 43.3 | Management of hepatocellular carcinoma. | Jordi Bruix, Morris Sherman, | Hepatology | 2005 | 16250051 | No |
| 2116 | 16202 | 1620.2 | 415.3 | 41.5 | Multilineage potential of adult human mesenchymal stem cells. | M F Pittenger, A M MacKay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak | Science | 1999 | 10102814 | Yes |
| 2117 | 1620 | 1620.0 | 35.1 | 35.1 | On finding all suboptimal foldings of an RNA molecule. | M Zuker | Science | 1989 | 2468181 | No |
| 2118 | 1620 | 1620.0 | 60.1 | 60.1 | The prevalence of 'alexithymic' characteristics in psychosomatic patients. | P E Sifneos | Psychother Psychosom | 1973 | 4770536 | Yes |
| 2119 | 1620 | 1620.0 | 48.8 | 48.8 | Levels of racism: a theoretic framework and a gardener's tale. | C P Jones | Am J Public Health | 2000 | 10936998 | Yes |
| 2120 | 1620 | 1620.0 | 82.1 | 82.1 | Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. | Douglas A Drossman | Gastroenterology | 2016 | 27144617 | Yes |
| 2121 | 3239 | 1619.5 | 88.2 | 44.1 | Diabetes and cardiovascular disease. The Framingham study. | W B Kannel, D L McGee | JAMA | 1979 | 430798 | Yes |
| 2122 | 3239 | 1619.5 | 85.8 | 42.9 | Receptors for purines and pyrimidines. | V Ralevic, G Burnstock | Pharmacol Rev | 1998 | 9755289 | No |
| 2123 | 1618 | 1618.0 | 29.6 | 29.6 | Altering the genome by homologous recombination. | M R Capecchi | Science | 1989 | 2660260 | No |
| 2124 | 1617 | 1617.0 | 35.5 | 35.5 | The caveolae membrane system. | R G Anderson | Annu Rev Biochem | 1998 | 9759488 | No |
| 2125 | 1617 | 1617.0 | 43.6 | 43.6 | Breakthrough of the year 2013. Cancer immunotherapy. | Jennifer Couzin-Frankel | Science | 2013 | 24357284 | No |
| 2126 | 3233 | 1616.5 | 105.0 | 52.5 | CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data. | Jing Huang, Alexander D MacKerell | J Comput Chem | 2013 | 23832629 | Yes |
| 2127 | 6465 | 1616.2 | 192.0 | 48.0 | Reversible middle cerebral artery occlusion without craniectomy in rats. | E Z Longa, P R Weinstein, S Carlson, R Cummins | Stroke | 1989 | 2643202 | Yes |
| 2128 | 1616 | 1616.0 | 65.3 | 65.3 | The Laboratory Rat: Relating Its Age With Human's. | Pallav Sengupta | Int J Prev Med | 2013 | 23930179 | Yes |
| 2129 | 9694 | 1615.7 | 375.4 | 62.6 | Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. | Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C Lowery | Implement Sci | 2009 | 19664226 | Yes |
| 2130 | 3231 | 1615.5 | 109.8 | 54.9 | A cognitive model of posttraumatic stress disorder. | A Ehlers, D M Clark | Behav Res Ther | 2000 | 10761279 | No |
| 2131 | 3231 | 1615.5 | 81.6 | 40.8 | Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. | F Q Schafer, G R Buettner | Free Radic Biol Med | 2001 | 11368918 | No |
| 2132 | 1615 | 1615.0 | 85.4 | 85.4 | The determinants of parenting: a process model. | J Belsky | Child Dev | 1984 | 6705636 | Yes |
| 2133 | 1615 | 1615.0 | 46.3 | 46.3 | Hemispheric asymmetry reduction in older adults: the HAROLD model. | Roberto Cabeza | Psychol Aging | 2002 | 11931290 | No |
| 2134 | 1614 | 1614.0 | 68.9 | 68.9 | Salience processing and insular cortical function and dysfunction. | Lucina Q Uddin | Nat Rev Neurosci | 2015 | 25406711 | No |
| 2135 | 1613 | 1613.0 | 56.1 | 56.1 | Density matrix formulation for quantum renormalization groups. | S R White | Phys Rev Lett | 1992 | 10046608 | Yes |
| 2136 | 4838 | 1612.7 | 93.6 | 31.2 | Notch signaling: cell fate control and signal integration in development. | S Artavanis-Tsakonas, M D Rand, R J Lake | Science | 1999 | 10221902 | No |
| 2137 | 8062 | 1612.4 | 163.8 | 32.8 | Prospective identification of tumorigenic breast cancer cells. | Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke | Proc Natl Acad Sci U S A | 2003 | 12629218 | Yes |
| 2138 | 3224 | 1612.0 | 92.3 | 46.1 | Polyamines. | C W Tabor, H Tabor | Annu Rev Biochem | 1984 | 6206782 | No |
| 2139 | 3224 | 1612.0 | 68.0 | 34.0 | Development by self-digestion: molecular mechanisms and biological functions of autophagy. | Beth Levine, Daniel J Klionsky | Dev Cell | 2004 | 15068787 | No |
| 2140 | 1611 | 1611.0 | 0.0 | 0.0 | Nutrition needs of mammalian cells in tissue culture. | H Eagle | Science | 1955 | 13255879 | Yes |
| 2141 | 4832 | 1610.7 | 129.9 | 43.3 | I-TASSER: a unified platform for automated protein structure and function prediction. | Ambrish Roy, Alper Kucukural, Yang Zhang | Nat Protoc | 2010 | 20360767 | Yes |
| 2142 | 3221 | 1610.5 | 111.9 | 56.0 | Social conditions as fundamental causes of disease. | B G Link, J Phelan | J Health Soc Behav | 1995 | 7560851 | No |
| 2143 | 3221 | 1610.5 | 97.3 | 48.6 | Oxidative stress, glutamate, and neurodegenerative disorders. | J T Coyle, P Puttfarcken | Science | 1993 | 7901908 | No |
| 2144 | 3221 | 1610.5 | 92.5 | 46.2 | Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. | Christine Vogel, Edward M Marcotte | Nat Rev Genet | 2012 | 22411467 | No |
| 2145 | 1610 | 1610.0 | 48.0 | 48.0 | Glycobiology: Toward Understanding the Function of Sugars. | Raymond A Dwek | Chem Rev | 1996 | 11848770 | Yes |
| 2146 | 4828 | 1609.3 | 128.5 | 42.8 | Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. | Y Zhang, M Brady, S Smith | IEEE Trans Med Imaging | 2001 | 11293691 | Yes |
| 2147 | 20900 | 1607.7 | 567.6 | 43.7 | Clustal W and Clustal X version 2.0. | M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins | Bioinformatics | 2007 | 17846036 | Yes |
| 2148 | 4822 | 1607.3 | 97.4 | 32.5 | Efficient selection for high-expression transfectants with a novel eukaryotic vector. | H Niwa, K Yamamura, J Miyazaki | Gene | 1991 | 1660837 | Yes |
| 2149 | 4822 | 1607.3 | 166.0 | 55.3 | Evaluating the public health impact of health promotion interventions: the RE-AIM framework. | R E Glasgow, T M Vogt, S M Boles | Am J Public Health | 1999 | 10474547 | No |
| 2150 | 3214 | 1607.0 | 119.8 | 59.9 | Avoiding false positives with PCR. | S Kwok, R Higuchi | Nature | 1989 | 2716852 | Yes |
| 2151 | 1607 | 1607.0 | 0.0 | 0.0 | The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. | A G Pearse | J Histochem Cytochem | 1969 | 4143745 | No |
| 2152 | 1607 | 1607.0 | 35.5 | 35.5 | Far-field optical nanoscopy. | Stefan W Hell | Science | 2007 | 17525330 | No |
| 2153 | 3212 | 1606.0 | 64.7 | 32.4 | Automated MAD and MIR structure solution. | T C Terwilliger, J Berendzen | Acta Crystallogr D Biol Crystallogr | 1999 | 10089316 | Yes |
| 2154 | 3211 | 1605.5 | 87.6 | 43.8 | Verification of protein structures: patterns of nonbonded atomic interactions. | C Colovos, T O Yeates | Protein Sci | 1993 | 8401235 | Yes |
| 2155 | 1605 | 1605.0 | 37.2 | 37.2 | Cellular oncogenes and retroviruses. | J M Bishop | Annu Rev Biochem | 1983 | 6351725 | No |
| 2156 | 1605 | 1605.0 | 39.6 | 39.6 | Pathogenesis of group A streptococcal infections. | M W Cunningham | Clin Microbiol Rev | 2000 | 10885988 | No |
| 2157 | 3208 | 1604.0 | 66.8 | 33.4 | Short-term synaptic plasticity. | Robert S Zucker, Wade G Regehr | Annu Rev Physiol | 2002 | 11826273 | No |
| 2158 | 19238 | 1603.2 | 1342.5 | 111.9 | The REDCap consortium: Building an international community of software platform partners. | Paul A Harris, Robert Taylor, Brenda L Minor, Veida Elliott, Michelle Fernandez, Lindsay O'Neal, Laura McLeod, Giovanni Delacqua, Francesco Delacqua, Jacqueline Kirby, Stephany N Duda, | J Biomed Inform | 2019 | 31078660 | Yes |
| 2159 | 1603 | 1603.0 | 72.9 | 72.9 | The measurement of psychological androgyny. | S L Bem | J Consult Clin Psychol | 1974 | 4823550 | Yes |
| 2160 | 3206 | 1603.0 | 69.2 | 34.6 | Inhibitors of mammalian G1 cyclin-dependent kinases. | C J Sherr, J M Roberts | Genes Dev | 1995 | 7758941 | No |
| 2161 | 1602 | 1602.0 | 83.7 | 83.7 | Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. | P De Leva | J Biomech | 1996 | 8872282 | Yes |
| 2162 | 1602 | 1602.0 | 0.0 | 0.0 | A New Weighting System For Mean Surface Temperature Of The Human Body. | N L Ramanathan | J Appl Physiol | 1964 | 14173555 | Yes |
| 2163 | 3202 | 1601.0 | 80.0 | 40.0 | A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1985 | 3156376 | Yes |
| 2164 | 1601 | 1601.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. | O Ouchterlony | Acta Pathol Microbiol Scand | 1953 | 13079779 | Yes |
| 2165 | 4801 | 1600.3 | 150.3 | 50.1 | Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. | S Van Der Linden, H A Valkenburg, A Cats | Arthritis Rheum | 1984 | 6231933 | Yes |
| 2166 | 1600 | 1600.0 | 32.2 | 32.2 | An analysis of vertebrate mRNA sequences: intimations of translational control. | M Kozak | J Cell Biol | 1991 | 1955461 | No |
| 2167 | 1600 | 1600.0 | 32.5 | 32.5 | The ubiquitin-proteasome proteolytic pathway. | A Ciechanover | Cell | 1994 | 7923371 | No |
| 2168 | 4799 | 1599.7 | 173.9 | 58.0 | Phylogenetic identification and in situ detection of individual microbial cells without cultivation. | R I Amann, W Ludwig, K H Schleifer | Microbiol Rev | 1995 | 7535888 | No |
| 2169 | 3198 | 1599.0 | 64.0 | 32.0 | Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. | O Tetsu, F McCormick | Nature | 1999 | 10201372 | Yes |
| 2170 | 1599 | 1599.0 | 49.8 | 49.8 | The pollution of the marine environment by plastic debris: a review. | Jose G B Derraik | Mar Pollut Bull | 2002 | 12405208 | No |
| 2171 | 4797 | 1599.0 | 154.3 | 51.4 | Mendelian randomization analysis with multiple genetic variants using summarized data. | Stephen Burgess, Adam Butterworth, Simon G Thompson | Genet Epidemiol | 2013 | 24114802 | Yes |
| 2172 | 1599 | 1599.0 | 67.9 | 67.9 | Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. | Daniel J Drucker | Cell Metab | 2018 | 29617641 | No |
| 2173 | 1598 | 1598.0 | 40.9 | 40.9 | Tumor necrosis factor (TNF). | L J Old | Science | 1985 | 2413547 | Yes |
| 2174 | 1598 | 1598.0 | 55.3 | 55.3 | AmpC beta-lactamases. | George A Jacoby | Clin Microbiol Rev | 2009 | 19136439 | No |
| 2175 | 4790 | 1596.7 | 192.2 | 64.1 | Job burnout. | C Maslach, W B Schaufeli, M P Leiter | Annu Rev Psychol | 2001 | 11148311 | Yes |
| 2176 | 1596 | 1596.0 | 0.0 | 0.0 | The intraclass correlation coefficient as a measure of reliability. | J J Bartko | Psychol Rep | 1966 | 5942109 | Yes |
| 2177 | 1595 | 1595.0 | 62.8 | 62.8 | Bias in analytic research. | D L Sackett | J Chronic Dis | 1979 | 447779 | Yes |
| 2178 | 1595 | 1595.0 | 39.5 | 39.5 | HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. | J M Coffin | Science | 1995 | 7824947 | Yes |
| 2179 | 1595 | 1595.0 | 51.0 | 51.0 | Domino Reactions in Organic Synthesis. | Lutz F Tietze | Chem Rev | 1996 | 11848746 | Yes |
| 2180 | 3188 | 1594.0 | 109.5 | 54.8 | Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. | John F Cryan, Timothy G Dinan | Nat Rev Neurosci | 2012 | 22968153 | No |
| 2181 | 1593 | 1593.0 | 46.5 | 46.5 | Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. | W H Oldendorf | Am J Physiol | 1971 | 5124307 | Yes |
| 2182 | 1593 | 1593.0 | 45.2 | 45.2 | The complete general secretory pathway in gram-negative bacteria. | A P Pugsley | Microbiol Rev | 1993 | 8096622 | No |
| 2183 | 1592 | 1592.0 | 66.3 | 66.3 | Reliability and factor analysis of the Epworth Sleepiness Scale. | M W Johns | Sleep | 1992 | 1519015 | Yes |
| 2184 | 1592 | 1592.0 | 48.1 | 48.1 | Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. | Louis B Rice | J Infect Dis | 2008 | 18419525 | No |
| 2185 | 1591 | 1591.0 | 37.1 | 37.1 | Recent advances in neuroblastoma. | John M Maris | N Engl J Med | 2010 | 20558371 | No |
| 2186 | 1590 | 1590.0 | 37.2 | 37.2 | VLA proteins in the integrin family: structures, functions, and their role on leukocytes. | M E Hemler | Annu Rev Immunol | 1990 | 2188667 | No |
| 2187 | 1590 | 1590.0 | 57.3 | 57.3 | Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. | J J Gross | J Pers Soc Psychol | 1998 | 9457784 | Yes |
| 2188 | 1589 | 1589.0 | 49.8 | 49.8 | Treatment of infections associated with surgical implants. | Rabih O Darouiche | N Engl J Med | 2004 | 15070792 | No |
| 2189 | 1589 | 1589.0 | 51.1 | 51.1 | Formation of glasses from liquids and biopolymers. | C A Angell | Science | 1995 | 17770101 | Yes |
| 2190 | 3176 | 1588.0 | 106.7 | 53.4 | From best evidence to best practice: effective implementation of change in patients' care. | Richard Grol, Jeremy Grimshaw | Lancet | 2003 | 14568747 | No |
| 2191 | 3174 | 1587.0 | 102.2 | 51.1 | The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. | R Doll, R Peto | J Natl Cancer Inst | 1981 | 7017215 | No |
| 2192 | 3174 | 1587.0 | 165.3 | 82.7 | Depression. | Gin S Malhi, J John Mann | Lancet | 2018 | 30396512 | No |
| 2193 | 3172 | 1586.0 | 100.6 | 50.3 | Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. | D S Bredt, S H Snyder | Proc Natl Acad Sci U S A | 1990 | 1689048 | Yes |
| 2194 | 1586 | 1586.0 | 36.4 | 36.4 | The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. | S E Kahn | Diabetologia | 2003 | 12637977 | No |
| 2195 | 1585 | 1585.0 | 29.9 | 29.9 | Germinal centers. | I C MacLennan | Annu Rev Immunol | 1994 | 8011279 | No |
| 2196 | 1585 | 1585.0 | 40.4 | 40.4 | Neuronal synchrony: a versatile code for the definition of relations? | W Singer | Neuron | 1999 | 10677026 | No |
| 2197 | 1584 | 1584.0 | 40.6 | 40.6 | Type I diabetes mellitus. A chronic autoimmune disease. | G S Eisenbarth | N Engl J Med | 1986 | 3517648 | No |
| 2198 | 1584 | 1584.0 | 37.4 | 37.4 | The proto-oncogene Bcl-2 and its role in regulating apoptosis. | G Kroemer | Nat Med | 1997 | 9176486 | No |
| 2199 | 1584 | 1584.0 | 0.0 | 0.0 | The Relation Of Recombination To Mutational Advance. | H J Muller | Mutat Res | 1964 | 14195748 | Yes |
| 2200 | 1584 | 1584.0 | 37.0 | 37.0 | Huntington's disease. | Francis O Walker | Lancet | 2007 | 17240289 | No |
| 2201 | 6334 | 1583.5 | 126.8 | 31.7 | A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. | B M Bolstad, R A Irizarry, M Astrand, T P Speed | Bioinformatics | 2003 | 12538238 | Yes |
| 2202 | 3166 | 1583.0 | 63.4 | 31.7 | Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. | C B Lozzio, B B Lozzio | Blood | 1975 | 163658 | Yes |
| 2203 | 1583 | 1583.0 | 0.0 | 0.0 | A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. | B C Hummel | Can J Biochem Physiol | 1959 | 14405350 | Yes |
| 2204 | 1583 | 1583.0 | 35.9 | 35.9 | Mitochondria: dynamic organelles in disease, aging, and development. | David C Chan | Cell | 2006 | 16814712 | No |
| 2205 | 1582 | 1582.0 | 43.5 | 43.5 | Molecular bases of the acute coronary syndromes. | P Libby | Circulation | 1995 | 7758192 | No |
| 2206 | 1582 | 1582.0 | 48.4 | 48.4 | The Danish Register of Causes of Death. | Karin Helweg-Larsen | Scand J Public Health | 2011 | 21775346 | Yes |
| 2207 | 1582 | 1582.0 | 63.2 | 63.2 | The variable nature of cognitive control: a dual mechanisms framework. | Todd S Braver | Trends Cogn Sci | 2012 | 22245618 | Yes |
| 2208 | 1581 | 1581.0 | 37.3 | 37.3 | Cell signaling. H2O2, a necessary evil for cell signaling. | Sue Goo Rhee | Science | 2006 | 16809515 | Yes |
| 2209 | 3162 | 1581.0 | 118.7 | 59.4 | MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets. | Martin Steinegger, Johannes Soding | Nat Biotechnol | 2017 | 29035372 | Yes |
| 2210 | 1580 | 1580.0 | 59.5 | 59.5 | Cardiac valve surgery--the "French correction". | A Carpentier | J Thorac Cardiovasc Surg | 1983 | 6887954 | Yes |
| 2211 | 1580 | 1580.0 | 34.1 | 34.1 | Physiological concentrations of purines and pyrimidines. | T W Traut | Mol Cell Biochem | 1994 | 7877593 | No |
| 2212 | 1579 | 1579.0 | 54.4 | 54.4 | Biology of interleukin 1. | C A Dinarello | FASEB J | 1988 | 3277884 | No |
| 2213 | 3158 | 1579.0 | 109.1 | 54.5 | The framing of decisions and the psychology of choice. | A Tversky, D Kahneman | Science | 1981 | 7455683 | Yes |
| 2214 | 3158 | 1579.0 | 84.3 | 42.1 | Empirical threshold values for quantitative trait mapping. | G A Churchill, R W Doerge | Genetics | 1994 | 7851788 | Yes |
| 2215 | 1579 | 1579.0 | 66.4 | 66.4 | Environmentally induced oxidative stress in aquatic animals. | Volodymyr I Lushchak | Aquat Toxicol | 2011 | 21074869 | No |
| 2216 | 1578 | 1578.0 | 45.6 | 45.6 | Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. | S Hakomori | Annu Rev Biochem | 1981 | 7023369 | No |
| 2217 | 1578 | 1578.0 | 57.6 | 57.6 | The non-canonical NF-κB pathway in immunity and inflammation. | Shao-Cong Sun | Nat Rev Immunol | 2017 | 28580957 | No |
| 2218 | 1577 | 1577.0 | 64.1 | 64.1 | Regulation of noradrenaline release by presynaptic receptor systems. | K Starke | Rev Physiol Biochem Pharmacol | 1977 | 14389 | No |
| 2219 | 1576 | 1576.0 | 43.8 | 43.8 | Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. | A Fabiato | Am J Physiol | 1983 | 6346892 | No |
| 2220 | 1576 | 1576.0 | 107.9 | 107.9 | The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. | F Denis | Spine (Phila Pa 1976) | 1983 | 6670016 | Yes |
| 2221 | 3152 | 1576.0 | 0.0 | 0.0 | Junctional complexes in various epithelia. | M G Farquhar, G E Palade | J Cell Biol | 1963 | 13944428 | Yes |
| 2222 | 1576 | 1576.0 | 68.7 | 68.7 | Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. | Dariush Mozaffarian | Circulation | 2016 | 26746178 | No |
| 2223 | 3151 | 1575.5 | 346.0 | 173.0 | The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth. | Karin E De Visser, Johanna A Joyce | Cancer Cell | 2023 | 36917948 | No |
| 2224 | 1575 | 1575.0 | 65.9 | 65.9 | How does sexual minority stigma "get under the skin"? A psychological mediation framework. | Mark L Hatzenbuehler | Psychol Bull | 2009 | 19702379 | No |
| 2225 | 4723 | 1574.3 | 202.1 | 67.4 | Hepatocellular carcinoma. | Alejandro Forner, Maria Reig, Jordi Bruix | Lancet | 2018 | 29307467 | No |
| 2226 | 1574 | 1574.0 | 34.2 | 34.2 | Autophagy: from phenomenology to molecular understanding in less than a decade. | Daniel J Klionsky | Nat Rev Mol Cell Biol | 2007 | 17712358 | No |
| 2227 | 1573 | 1573.0 | 61.3 | 61.3 | Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. | P Holzer | Neuroscience | 1988 | 3288903 | No |
| 2228 | 4718 | 1572.7 | 174.5 | 58.2 | Factor structure of the Barratt impulsiveness scale. | J H Patton, M S Stanford, E S Barratt | J Clin Psychol | 1995 | 8778124 | Yes |
| 2229 | 1572 | 1572.0 | 66.5 | 66.5 | Minority stress and mental health in gay men. | I H Meyer | J Health Soc Behav | 1995 | 7738327 | Yes |
| 2230 | 1571 | 1571.0 | 44.7 | 44.7 | Genetic consequences of climatic oscillations in the Quaternary. | G M Hewitt | Philos Trans R Soc Lond B Biol Sci | 2004 | 15101575 | No |
| 2231 | 1570 | 1570.0 | 33.2 | 33.2 | Cancer epigenomics: DNA methylomes and histone-modification maps. | Manel Esteller | Nat Rev Genet | 2007 | 17339880 | No |
| 2232 | 1570 | 1570.0 | 43.0 | 43.0 | Regulation of glutathione synthesis. | Shelly C Lu | Mol Aspects Med | 2009 | 18601945 | No |
| 2233 | 7847 | 1569.4 | 193.9 | 38.8 | Jalview Version 2--a multiple sequence alignment editor and analysis workbench. | Andrew M Waterhouse, James B Procter, David M A Martin, Michele Clamp, Geoffrey J Barton | Bioinformatics | 2009 | 19151095 | Yes |
| 2234 | 4706 | 1568.7 | 114.6 | 38.2 | Wnt/beta-catenin signaling: components, mechanisms, and diseases. | Bryan T MacDonald, Keiko Tamai, Xi He | Dev Cell | 2009 | 19619488 | No |
| 2235 | 10980 | 1568.6 | 242.4 | 34.6 | Embryonic stem cell lines derived from human blastocysts. | J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones | Science | 1998 | 9804556 | Yes |
| 2236 | 3137 | 1568.5 | 0.0 | 0.0 | Computed circular dichroism spectra for the evaluation of protein conformation. | N Greenfield, G D Fasman | Biochemistry | 1969 | 5346390 | Yes |
| 2237 | 1568 | 1568.0 | 40.6 | 40.6 | Proinflammatory cytokines. | C A Dinarello | Chest | 2000 | 10936147 | No |
| 2238 | 1568 | 1568.0 | 30.2 | 30.2 | Aggresomes, inclusion bodies and protein aggregation. | R R Kopito | Trends Cell Biol | 2000 | 11121744 | No |
| 2239 | 1568 | 1568.0 | 51.2 | 51.2 | Depression in late life: review and commentary. | Dan G Blazer | J Gerontol A Biol Sci Med Sci | 2003 | 12634292 | No |
| 2240 | 3136 | 1568.0 | 89.1 | 44.5 | Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. | Robert E W Hancock, Hans-Georg Sahl | Nat Biotechnol | 2006 | 17160061 | No |
| 2241 | 3136 | 1568.0 | 82.2 | 41.1 | Tumor metastasis: molecular insights and evolving paradigms. | Scott Valastyan, Robert A Weinberg | Cell | 2011 | 22000009 | No |
| 2242 | 4701 | 1567.0 | 135.0 | 45.0 | AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. | G Paxinos, C R Watson, P C Emson | J Neurosci Methods | 1980 | 6110810 | Yes |
| 2243 | 3134 | 1567.0 | 70.7 | 35.4 | Cell migration: a physically integrated molecular process. | D A Lauffenburger, A F Horwitz | Cell | 1996 | 8608589 | No |
| 2244 | 1567 | 1567.0 | 62.1 | 62.1 | Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? | Fay B Horak | Age Ageing | 2006 | 16926210 | No |
| 2245 | 1566 | 1566.0 | 70.9 | 70.9 | Stimulated acoustic emissions from within the human auditory system. | D T Kemp | J Acoust Soc Am | 1978 | 744838 | Yes |
| 2246 | 1566 | 1566.0 | 44.0 | 44.0 | Diagnosis of osteoporosis and assessment of fracture risk. | John A Kanis | Lancet | 2002 | 12057569 | No |
| 2247 | 1566 | 1566.0 | 45.6 | 45.6 | A comprehensive definition for metabolic syndrome. | Paul L Huang | Dis Model Mech | 2009 | 19407331 | No |
| 2248 | 3132 | 1566.0 | 99.2 | 49.6 | Liquid phase condensation in cell physiology and disease. | Yongdae Shin, Clifford P Brangwynne | Science | 2017 | 28935776 | No |
| 2249 | 3131 | 1565.5 | 64.7 | 32.4 | Toll-like receptor control of the adaptive immune responses. | Akiko Iwasaki, Ruslan Medzhitov | Nat Immunol | 2004 | 15454922 | No |
| 2250 | 1565 | 1565.0 | 45.1 | 45.1 | Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. | Michael F Holick | Am J Clin Nutr | 2004 | 15585788 | No |
| 2251 | 4693 | 1564.3 | 118.8 | 39.6 | Cell death: the significance of apoptosis. | A H Wyllie, J F Kerr, A R Currie | Int Rev Cytol | 1980 | 7014501 | No |
| 2252 | 1564 | 1564.0 | 47.8 | 47.8 | Equipoise and the ethics of clinical research. | B Freedman | N Engl J Med | 1987 | 3600702 | Yes |
| 2253 | 1564 | 1564.0 | 46.7 | 46.7 | Strong localization of photons in certain disordered dielectric superlattices. | S John | Phys Rev Lett | 1987 | 10034761 | Yes |
| 2254 | 3128 | 1564.0 | 113.8 | 56.9 | Kraken: ultrafast metagenomic sequence classification using exact alignments. | Derrick E Wood, Steven L Salzberg | Genome Biol | 2014 | 24580807 | Yes |
| 2255 | 3126 | 1563.0 | 63.6 | 31.8 | Intrinsically unstructured proteins and their functions. | H Jane Dyson, Peter E Wright | Nat Rev Mol Cell Biol | 2005 | 15738986 | No |
| 2256 | 3126 | 1563.0 | 103.0 | 51.5 | Functional interactions between the gut microbiota and host metabolism. | Valentina Tremaroli, Fredrik Backhed | Nature | 2012 | 22972297 | No |
| 2257 | 1562 | 1562.0 | 36.7 | 36.7 | The molecular logic of endocannabinoid signalling. | Daniele Piomelli | Nat Rev Neurosci | 2003 | 14595399 | No |
| 2258 | 1562 | 1562.0 | 52.8 | 52.8 | Photoplethysmography and its application in clinical physiological measurement. | John Allen | Physiol Meas | 2007 | 17322588 | No |
| 2259 | 4684 | 1561.3 | 177.1 | 59.0 | Principles of nanoparticle design for overcoming biological barriers to drug delivery. | Elvin Blanco, Haifa Shen, Mauro Ferrari | Nat Biotechnol | 2015 | 26348965 | Yes |
| 2260 | 1561 | 1561.0 | 48.2 | 48.2 | The collagen family. | Sylvie Ricard-Blum | Cold Spring Harb Perspect Biol | 2011 | 21421911 | No |
| 2261 | 3120 | 1560.0 | 76.7 | 38.4 | Emerging roles of caspase-3 in apoptosis. | A G Porter, R U Janicke | Cell Death Differ | 1999 | 10200555 | No |
| 2262 | 1560 | 1560.0 | 0.0 | 0.0 | The estimation of phosphorus. | R J Allen | Biochem J | 1940 | 16747230 | Yes |
| 2263 | 3120 | 1560.0 | 0.0 | 0.0 | Mutations of Bacteria from Virus Sensitivity to Virus Resistance. | S E Luria, M Delbruck | Genetics | 1943 | 17247100 | Yes |
| 2264 | 1559 | 1559.0 | 43.5 | 43.5 | An economic method for the fluorescent labeling of PCR fragments. | M Schuelke | Nat Biotechnol | 2000 | 10657137 | Yes |
| 2265 | 1559 | 1559.0 | 48.9 | 48.9 | Species concepts and species delimitation. | Kevin De Queiroz | Syst Biol | 2007 | 18027281 | Yes |
| 2266 | 1558 | 1558.0 | 44.0 | 44.0 | Biological applications of ionophores. | B C Pressman | Annu Rev Biochem | 1976 | 786156 | No |
| 2267 | 1558 | 1558.0 | 43.0 | 43.0 | Graphene transistors. | Frank Schwierz | Nat Nanotechnol | 2010 | 20512128 | Yes |
| 2268 | 1557 | 1557.0 | 44.8 | 44.8 | Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. | A E Pegg | Cancer Res | 1988 | 3123052 | No |
| 2269 | 1557 | 1557.0 | 41.2 | 41.2 | The amygdala modulates the consolidation of memories of emotionally arousing experiences. | James L McGaugh | Annu Rev Neurosci | 2004 | 15217324 | No |
| 2270 | 3110 | 1555.0 | 95.6 | 47.8 | CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. | Mattias Jakobsson, Noah A Rosenberg | Bioinformatics | 2007 | 17485429 | Yes |
| 2271 | 3108 | 1554.0 | 109.2 | 54.6 | Liposomal drug delivery systems: from concept to clinical applications. | Theresa M Allen, Pieter R Cullis | Adv Drug Deliv Rev | 2013 | 23036225 | No |
| 2272 | 1553 | 1553.0 | 0.0 | 0.0 | A soluble protein characteristic of the nervous system. | B W Moore | Biochem Biophys Res Commun | 1965 | 4953930 | Yes |
| 2273 | 4659 | 1553.0 | 102.2 | 34.1 | TOR signaling in growth and metabolism. | Stephan Wullschleger, Robbie Loewith, Michael N Hall | Cell | 2006 | 16469695 | No |
| 2274 | 3105 | 1552.5 | 78.0 | 39.0 | Myocardial reperfusion injury. | Derek M Yellon, Derek J Hausenloy | N Engl J Med | 2007 | 17855673 | No |
| 2275 | 3105 | 1552.5 | 100.0 | 50.0 | DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. | Yan Chao-Gan, Zang Yu-Feng | Front Syst Neurosci | 2010 | 20577591 | Yes |
| 2276 | 4656 | 1552.0 | 104.4 | 34.8 | Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. | M A Frohman, M K Dush, G R Martin | Proc Natl Acad Sci U S A | 1988 | 2461560 | Yes |
| 2277 | 1552 | 1552.0 | 33.8 | 33.8 | The enzymes, regulation, and genetics of bile acid synthesis. | David W Russell | Annu Rev Biochem | 2003 | 12543708 | No |
| 2278 | 1552 | 1552.0 | 51.5 | 51.5 | Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. | M Robin DiMatteo | Med Care | 2004 | 15076819 | Yes |
| 2279 | 3103 | 1551.5 | 84.1 | 42.0 | An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. | Gary Aston-Jones, Jonathan D Cohen | Annu Rev Neurosci | 2005 | 16022602 | No |
| 2280 | 1551 | 1551.0 | 53.5 | 53.5 | Gene flow and the geographic structure of natural populations. | M Slatkin | Science | 1987 | 3576198 | Yes |
| 2281 | 1551 | 1551.0 | 38.2 | 38.2 | Origin, biogenesis, and activity of plant microRNAs. | Olivier Voinnet | Cell | 2009 | 19239888 | No |
| 2282 | 3101 | 1550.5 | 173.4 | 86.7 | Sarcopenia. | Alfonso J Cruz-Jentoft, Avan A Sayer | Lancet | 2019 | 31171417 | No |
| 2283 | 1549 | 1549.0 | 59.2 | 59.2 | Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. | P Holzer | Pharmacol Rev | 1991 | 1852779 | No |
| 2284 | 1549 | 1549.0 | 44.6 | 44.6 | Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. | Y Ben-Ari | Neuroscience | 1985 | 2859548 | No |
| 2285 | 3097 | 1548.5 | 74.0 | 37.0 | How matrix metalloproteinases regulate cell behavior. | M D Sternlicht, Z Werb | Annu Rev Cell Dev Biol | 2001 | 11687497 | No |
| 2286 | 4645 | 1548.3 | 110.1 | 36.7 | Long non-coding RNAs: insights into functions. | Tim R Mercer, Marcel E Dinger, John S Mattick | Nat Rev Genet | 2009 | 19188922 | No |
| 2287 | 1548 | 1548.0 | 46.8 | 46.8 | Biological basis of the behavior of sick animals. | B L Hart | Neurosci Biobehav Rev | 1988 | 3050629 | No |
| 2288 | 7739 | 1547.8 | 320.8 | 64.2 | DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. | O Folmer, M Black, W Hoeh, R Lutz, R Vrijenhoek | Mol Mar Biol Biotechnol | 1994 | 7881515 | Yes |
| 2289 | 4643 | 1547.7 | 98.6 | 32.9 | The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. | S K Hanks, A M Quinn, T Hunter | Science | 1988 | 3291115 | No |
| 2290 | 1546 | 1546.0 | 64.5 | 64.5 | The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. | Natalie A De Morton | Aust J Physiother | 2009 | 19463084 | Yes |
| 2291 | 1545 | 1545.0 | 44.9 | 44.9 | Atherogenesis: a postprandial phenomenon. | D B Zilversmit | Circulation | 1979 | 222498 | Yes |
| 2292 | 1545 | 1545.0 | 0.0 | 0.0 | The glomerular permeability determined by dextran clearance using Sephadex gel filtration. | C E Mogensen | Scand J Clin Lab Invest | 1968 | 5637478 | Yes |
| 2293 | 1545 | 1545.0 | 30.8 | 30.8 | The significance of responses of the genome to challenge. | B McClintock | Science | 1984 | 15739260 | No |
| 2294 | 3089 | 1544.5 | 102.9 | 51.5 | New Giemsa method for the differential staining of sister chromatids. | P Perry, S Wolff | Nature | 1974 | 4138930 | Yes |
| 2295 | 1544 | 1544.0 | 39.8 | 39.8 | R factor transfer in Rhizobium leguminosarum. | J E Beringer | J Gen Microbiol | 1974 | 4612098 | Yes |
| 2296 | 1544 | 1544.0 | 63.1 | 63.1 | Diagnostic and Statistical Manual of Mental Disorders (DSM). | Dolores Elaine Battle | Codas | 2013 | 24413388 | Yes |
| 2297 | 4631 | 1543.7 | 130.0 | 43.3 | A highly sensitive adenylate cyclase assay. | Y Salomon, C Londos, M Rodbell | Anal Biochem | 1974 | 4827395 | Yes |
| 2298 | 3086 | 1543.0 | 98.4 | 49.2 | Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. | P J Basser, C Pierpaoli | J Magn Reson B | 1996 | 8661285 | Yes |
| 2299 | 1542 | 1542.0 | 0.0 | 0.0 | The perceptron: a probabilistic model for information storage and organization in the brain. | F Rosenblatt | Psychol Rev | 1958 | 13602029 | Yes |
| 2300 | 3082 | 1541.0 | 66.0 | 33.0 | The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. | M S Brown, J L Goldstein | Cell | 1997 | 9150132 | No |
| 2301 | 1541 | 1541.0 | 29.2 | 29.2 | CD4+ CD25+ suppressor T cells: more questions than answers. | Ethan M Shevach | Nat Rev Immunol | 2002 | 12093005 | No |
| 2302 | 1540 | 1540.0 | 47.7 | 47.7 | Leishmaniasis: current situation and new perspectives. | P Desjeux | Comp Immunol Microbiol Infect Dis | 2004 | 15225981 | No |
| 2303 | 3079 | 1539.5 | 130.0 | 65.0 | Organic Photoredox Catalysis. | Nathan A Romero, David A Nicewicz | Chem Rev | 2016 | 27285582 | Yes |
| 2304 | 1539 | 1539.0 | 30.7 | 30.7 | E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. | J R Nevins | Science | 1992 | 1411535 | Yes |
| 2305 | 1539 | 1539.0 | 44.0 | 44.0 | The world health report 2002 - reducing risks, promoting healthy life. | J J Guilbert | Educ Health (Abingdon) | 2003 | 14741909 | Yes |
| 2306 | 1539 | 1539.0 | 59.2 | 59.2 | Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. | T Florian Jaeger | J Mem Lang | 2008 | 19884961 | Yes |
| 2307 | 3077 | 1538.5 | 0.0 | 0.0 | A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. | G Schmidt, S J Thannhauser | J Biol Chem | 1945 | 21005717 | Yes |
| 2308 | 1538 | 1538.0 | 0.0 | 0.0 | Codon--anticodon pairing: the wobble hypothesis. | F H Crick | J Mol Biol | 1966 | 5969078 | Yes |
| 2309 | 24598 | 1537.4 | 702.6 | 43.9 | New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). | E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J Verweij | Eur J Cancer | 2009 | 19097774 | No |
| 2310 | 1537 | 1537.0 | 27.6 | 27.6 | Histone acetylation and transcriptional regulatory mechanisms. | K Struhl | Genes Dev | 1998 | 9499396 | No |
| 2311 | 1536 | 1536.0 | 75.4 | 75.4 | Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design. | Nicholas A Meanwell | J Med Chem | 2018 | 29400967 | No |
| 2312 | 4605 | 1535.0 | 99.9 | 33.3 | Telomeres shorten during ageing of human fibroblasts. | C B Harley, A B Futcher, C W Greider | Nature | 1990 | 2342578 | Yes |
| 2313 | 1535 | 1535.0 | 44.7 | 44.7 | The debate over dopamine's role in reward: the case for incentive salience. | Kent C Berridge | Psychopharmacology (Berl) | 2007 | 17072591 | No |
| 2314 | 1534 | 1534.0 | 45.6 | 45.6 | Statistical analysis of enzyme kinetic data. | W W Cleland | Methods Enzymol | 1979 | 502857 | Yes |
| 2315 | 1534 | 1534.0 | 34.7 | 34.7 | Molecular themes in oncogenesis. | J M Bishop | Cell | 1991 | 1988146 | No |
| 2316 | 1534 | 1534.0 | 42.7 | 42.7 | Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. | L A Liotta | Cancer Res | 1986 | 2998604 | No |
| 2317 | 1534 | 1534.0 | 47.7 | 47.7 | Recent advances in the biochemistry of polyamines in eukaryotes. | A E Pegg | Biochem J | 1986 | 3087344 | No |
| 2318 | 1534 | 1534.0 | 52.6 | 52.6 | Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. | H J Gundersen | J Microsc | 1986 | 3761363 | Yes |
| 2319 | 1534 | 1534.0 | 66.9 | 66.9 | The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. | E J Khantzian | Am J Psychiatry | 1985 | 3904487 | No |
| 2320 | 1534 | 1534.0 | 43.8 | 43.8 | The epidemiology of venous thromboembolism. | Richard H White | Circulation | 2003 | 12814979 | No |
| 2321 | 1534 | 1534.0 | 60.3 | 60.3 | The evolving concept of health literacy. | Don Nutbeam | Soc Sci Med | 2008 | 18952344 | Yes |
| 2322 | 3068 | 1534.0 | 73.4 | 36.7 | Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. | Subhra K Biswas, Alberto Mantovani | Nat Immunol | 2010 | 20856220 | No |
| 2323 | 6135 | 1533.8 | 141.7 | 35.4 | Probability-based protein identification by searching sequence databases using mass spectrometry data. | D N Perkins, D J Pappin, D M Creasy, J S Cottrell | Electrophoresis | 1999 | 10612281 | Yes |
| 2324 | 1533 | 1533.0 | 58.9 | 58.9 | The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. | A Raine | Schizophr Bull | 1991 | 1805349 | Yes |
| 2325 | 1533 | 1533.0 | 27.2 | 27.2 | The economics of ribosome biosynthesis in yeast. | J R Warner | Trends Biochem Sci | 1999 | 10542411 | No |
| 2326 | 4597 | 1532.3 | 130.9 | 43.6 | Hydroperoxide metabolism in mammalian organs. | B Chance, H Sies, A Boveris | Physiol Rev | 1979 | 37532 | Yes |
| 2327 | 4597 | 1532.3 | 0.0 | 0.0 | Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. | C A Winter, E A Risley, G W Nuss | Proc Soc Exp Biol Med | 1962 | 14001233 | Yes |
| 2328 | 1532 | 1532.0 | 59.1 | 59.1 | Enhancing the quality and credibility of qualitative analysis. | M Q Patton | Health Serv Res | 1999 | 10591279 | No |
| 2329 | 1532 | 1532.0 | 57.1 | 57.1 | Sensorimotor integration in human postural control. | R J Peterka | J Neurophysiol | 2002 | 12205132 | Yes |
| 2330 | 3064 | 1532.0 | 70.1 | 35.0 | Cell cycle, CDKs and cancer: a changing paradigm. | Marcos Malumbres, Mariano Barbacid | Nat Rev Cancer | 2009 | 19238148 | No |
| 2331 | 1532 | 1532.0 | 35.1 | 35.1 | Tumour necrosis factor and cancer. | Frances Balkwill | Nat Rev Cancer | 2009 | 19343034 | No |
| 2332 | 3063 | 1531.5 | 98.1 | 49.0 | Functional architecture of basal ganglia circuits: neural substrates of parallel processing. | G E Alexander, M D Crutcher | Trends Neurosci | 1990 | 1695401 | No |
| 2333 | 3060 | 1530.0 | 77.6 | 38.8 | Peptidoglycan types of bacterial cell walls and their taxonomic implications. | K H Schleifer, O Kandler | Bacteriol Rev | 1972 | 4568761 | No |
| 2334 | 1530 | 1530.0 | 38.2 | 38.2 | What is a support vector machine? | William S Noble | Nat Biotechnol | 2006 | 17160063 | No |
| 2335 | 1530 | 1530.0 | 51.5 | 51.5 | Myeloid-Derived Suppressor Cells. | Dmitry I Gabrilovich | Cancer Immunol Res | 2017 | 28052991 | No |
| 2336 | 1529 | 1529.0 | 41.6 | 41.6 | Stress and hippocampal plasticity. | B S McEwen | Annu Rev Neurosci | 1999 | 10202533 | No |
| 2337 | 1529 | 1529.0 | 42.2 | 42.2 | Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. | Russell Lande | Evolution | 1979 | 28568194 | Yes |
| 2338 | 1528 | 1528.0 | 0.0 | 0.0 | Some observations upon a new inhibitor of monoamine oxidase in brain tissue. | J P Johnston | Biochem Pharmacol | 1968 | 5659776 | Yes |
| 2339 | 1528 | 1528.0 | 55.1 | 55.1 | Health consequences of obesity in youth: childhood predictors of adult disease. | W H Dietz | Pediatrics | 1998 | 12224658 | No |
| 2340 | 1528 | 1528.0 | 0.0 | 0.0 | Modality and topographic properties of single neurons of cat's somatic sensory cortex. | V B Mountcastle | J Neurophysiol | 1957 | 13439410 | Yes |
| 2341 | 1528 | 1528.0 | 0.0 | 0.0 | Antigen-Antibody Crossed Electrophoresis. | C B Laurell | Anal Biochem | 1965 | 14302464 | Yes |
| 2342 | 3056 | 1528.0 | 77.3 | 38.6 | Powering the planet: chemical challenges in solar energy utilization. | Nathan S Lewis, Daniel G Nocera | Proc Natl Acad Sci U S A | 2006 | 17043226 | Yes |
| 2343 | 1528 | 1528.0 | 39.1 | 39.1 | TNF-mediated inflammatory disease. | J R Bradley | J Pathol | 2008 | 18161752 | No |
| 2344 | 7638 | 1527.6 | 307.8 | 61.6 | Evidence based medicine: what it is and what it isn't. | D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson | BMJ | 1996 | 8555924 | No |
| 2345 | 3055 | 1527.5 | 62.0 | 31.0 | Autophagy as a regulated pathway of cellular degradation. | D J Klionsky, S D Emr | Science | 2000 | 11099404 | No |
| 2346 | 3054 | 1527.0 | 78.8 | 39.4 | Synchronization of Plasmodium falciparum erythrocytic stages in culture. | C Lambros, J P Vanderberg | J Parasitol | 1979 | 383936 | Yes |
| 2347 | 1527 | 1527.0 | 40.8 | 40.8 | Optimal foraging, the marginal value theorem. | E L Charnov | Theor Popul Biol | 1976 | 1273796 | Yes |
| 2348 | 1527 | 1527.0 | 0.0 | 0.0 | An enzymic method for the trace iodination of immunoglobulins and other proteins. | J J Marchalonis | Biochem J | 1969 | 4185494 | Yes |
| 2349 | 1527 | 1527.0 | 0.0 | 0.0 | Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. | J W Olney | Science | 1969 | 5778021 | Yes |
| 2350 | 1527 | 1527.0 | 63.1 | 63.1 | Translating social ecological theory into guidelines for community health promotion. | D Stokols | Am J Health Promot | 1996 | 10159709 | No |
| 2351 | 1526 | 1526.0 | 44.6 | 44.6 | Calcium release from the sarcoplasmic reticulum. | M Endo | Physiol Rev | 1977 | 13441 | Yes |
| 2352 | 3051 | 1525.5 | 98.3 | 49.1 | Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. | Aluisio J D Barros, Vania N Hirakata | BMC Med Res Methodol | 2003 | 14567763 | Yes |
| 2353 | 1525 | 1525.0 | 0.0 | 0.0 | The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. | O V Batson | Ann Surg | 1940 | 17857618 | Yes |
| 2354 | 15246 | 1524.6 | 595.8 | 59.6 | MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. | Fredrik Ronquist, Maxim Teslenko, Paul Van Der Mark, Daniel L Ayres, Aaron Darling, Sebastian Hohna, Bret Larget, Liang Liu, Marc A Suchard, John P Huelsenbeck | Syst Biol | 2012 | 22357727 | Yes |
| 2355 | 9145 | 1524.2 | 336.2 | 56.0 | Second-generation PLINK: rising to the challenge of larger and richer datasets. | Christopher C Chang, Carson C Chow, Laurent Cam Tellier, Shashaank Vattikuti, Shaun M Purcell, James J Lee | Gigascience | 2015 | 25722852 | Yes |
| 2356 | 1523 | 1523.0 | 40.3 | 40.3 | Early signals in the mitogenic response. | E Rozengurt | Science | 1986 | 3018928 | No |
| 2357 | 1523 | 1523.0 | 57.8 | 57.8 | How stigma interferes with mental health care. | Patrick Corrigan | Am Psychol | 2004 | 15491256 | Yes |
| 2358 | 3046 | 1523.0 | 91.7 | 45.9 | Relaxing the rule of ten events per variable in logistic and Cox regression. | Eric Vittinghoff, Charles E McCulloch | Am J Epidemiol | 2007 | 17182981 | Yes |
| 2359 | 7614 | 1522.8 | 246.0 | 49.2 | CD-HIT: accelerated for clustering the next-generation sequencing data. | Limin Fu, Beifang Niu, Zhengwei Zhu, Sitao Wu, Weizhong Li | Bioinformatics | 2012 | 23060610 | Yes |
| 2360 | 1522 | 1522.0 | 0.0 | 0.0 | Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. | K Fuxe | Acta Physiol Scand Suppl | 1965 | 14319769 | Yes |
| 2361 | 1522 | 1522.0 | 45.8 | 45.8 | Function and information content of DNA methylation. | Dirk Schubeler | Nature | 2015 | 25592537 | No |
| 2362 | 1521 | 1521.0 | 51.1 | 51.1 | Polycystic ovary syndrome. | S Franks | N Engl J Med | 1995 | 7651477 | No |
| 2363 | 1521 | 1521.0 | 59.1 | 59.1 | How neuroinflammation contributes to neurodegeneration. | Richard M Ransohoff | Science | 2016 | 27540165 | No |
| 2364 | 3040 | 1520.0 | 92.8 | 46.4 | Chlorophyll fluorescence--a practical guide. | K Maxwell, G N Johnson | J Exp Bot | 2000 | 10938857 | No |
| 2365 | 1520 | 1520.0 | 38.3 | 38.3 | Oxidative stress in Parkinson's disease. | Peter Jenner | Ann Neurol | 2003 | 12666096 | No |
| 2366 | 1520 | 1520.0 | 49.8 | 49.8 | The functional gastrointestinal disorders and the Rome III process. | Douglas A Drossman | Gastroenterology | 2006 | 16678553 | No |
| 2367 | 3037 | 1518.5 | 133.3 | 66.7 | New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. | Anushka Dongre, Robert A Weinberg | Nat Rev Mol Cell Biol | 2019 | 30459476 | No |
| 2368 | 1518 | 1518.0 | 39.2 | 39.2 | Trophic factors and neuronal survival. | Y A Barde | Neuron | 1989 | 2697237 | No |
| 2369 | 1518 | 1518.0 | 0.0 | 0.0 | An approximate distribution of estimates of variance components. | F E Satterthwaite | Biometrics | 1946 | 20287815 | Yes |
| 2370 | 10624 | 1517.7 | 427.8 | 61.1 | Development and validation of a geriatric depression screening scale: a preliminary report. | J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer | J Psychiatr Res | 1982 | 7183759 | Yes |
| 2371 | 1517 | 1517.0 | 50.6 | 50.6 | The structure of beta-lactamases. | R P Ambler | Philos Trans R Soc Lond B Biol Sci | 1980 | 6109327 | Yes |
| 2372 | 6068 | 1517.0 | 166.6 | 41.6 | AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. | Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan | Nat Cell Biol | 2011 | 21258367 | Yes |
| 2373 | 4549 | 1516.3 | 103.4 | 34.5 | Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. | Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen | Science | 2005 | 15831717 | Yes |
| 2374 | 1516 | 1516.0 | 39.6 | 39.6 | Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. | H S Penefsky | J Biol Chem | 1977 | 16006 | Yes |
| 2375 | 1516 | 1516.0 | 46.6 | 46.6 | Isolated removal of hypothalamic or other brain nuclei of the rat. | M Palkovits | Brain Res | 1973 | 4747772 | Yes |
| 2376 | 1516 | 1516.0 | 43.0 | 43.0 | Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. | Felix Kratz | J Control Release | 2008 | 18582981 | No |
| 2377 | 1515 | 1515.0 | 39.1 | 39.1 | Stability of proteins: small globular proteins. | P L Privalov | Adv Protein Chem | 1979 | 44431 | No |
| 2378 | 1514 | 1514.0 | 36.2 | 36.2 | Microbial ecology of the gastrointestinal tract. | D C Savage | Annu Rev Microbiol | 1977 | 334036 | No |
| 2379 | 1514 | 1514.0 | 34.8 | 34.8 | Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. | M B Luskin | Neuron | 1993 | 8338665 | Yes |
| 2380 | 9084 | 1514.0 | 285.5 | 47.6 | Prodigal: prokaryotic gene recognition and translation initiation site identification. | Doug Hyatt, Gwo-Liang Chen, Philip F Locascio, Miriam L Land, Frank W Larimer, Loren J Hauser | BMC Bioinformatics | 2010 | 20211023 | Yes |
| 2381 | 3027 | 1513.5 | 59.6 | 29.8 | Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. | P J Mitchell, R Tjian | Science | 1989 | 2667136 | No |
| 2382 | 1513 | 1513.0 | 44.3 | 44.3 | Superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1975 | 1094908 | No |
| 2383 | 1513 | 1513.0 | 0.0 | 0.0 | Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. | R W Sperry | Proc Natl Acad Sci U S A | 1963 | 14077501 | Yes |
| 2384 | 3026 | 1513.0 | 75.8 | 37.9 | The ubiquitin code. | David Komander, Michael Rape | Annu Rev Biochem | 2012 | 22524316 | No |
| 2385 | 1513 | 1513.0 | 78.3 | 78.3 | Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges. | Dimitrios Tsikas | Anal Biochem | 2017 | 27789233 | No |
| 2386 | 10588 | 1512.6 | 684.0 | 97.7 | IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era. | Bui Quang Minh, Heiko A Schmidt, Olga Chernomor, Dominik Schrempf, Michael D Woodhams, Arndt Von Haeseler, Robert Lanfear | Mol Biol Evol | 2020 | 32011700 | Yes |
| 2387 | 3025 | 1512.5 | 121.4 | 60.7 | Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. | L F Berkman, S L Syme | Am J Epidemiol | 1979 | 425958 | Yes |
| 2388 | 1512 | 1512.0 | 41.4 | 41.4 | The human orbitofrontal cortex: linking reward to hedonic experience. | Morten L Kringelbach | Nat Rev Neurosci | 2005 | 16136173 | No |
| 2389 | 3024 | 1512.0 | 112.5 | 56.2 | AKT/PKB Signaling: Navigating the Network. | Brendan D Manning, Alex Toker | Cell | 2017 | 28431241 | No |
| 2390 | 1511 | 1511.0 | 46.0 | 46.0 | Recent developments in isocyanide based multicomponent reactions in applied chemistry. | Alexander Domling | Chem Rev | 2006 | 16402771 | No |
| 2391 | 3021 | 1510.5 | 96.3 | 48.1 | The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. | W R Gibb, A J Lees | J Neurol Neurosurg Psychiatry | 1988 | 2841426 | No |
| 2392 | 1510 | 1510.0 | 0.0 | 0.0 | The mechanism of muscular contraction. | H E Huxley | Science | 1969 | 4181952 | No |
| 2393 | 3019 | 1509.5 | 130.6 | 65.3 | Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. | R Vilgalys, M Hester | J Bacteriol | 1990 | 2376561 | Yes |
| 2394 | 1509 | 1509.0 | 40.2 | 40.2 | The complex role of estrogens in inflammation. | Rainer H Straub | Endocr Rev | 2007 | 17640948 | No |
| 2395 | 4524 | 1508.0 | 106.1 | 35.4 | OrthoMCL: identification of ortholog groups for eukaryotic genomes. | Li Li, Christian J Stoeckert, David S Roos | Genome Res | 2003 | 12952885 | Yes |
| 2396 | 1508 | 1508.0 | 36.0 | 36.0 | The cancer stem cell: premises, promises and challenges. | Hans Clevers | Nat Med | 2011 | 21386835 | No |
| 2397 | 3015 | 1507.5 | 0.0 | 0.0 | Lactic dehydrogenase activity in blood. | F Wroblewski, J S Ladue | Proc Soc Exp Biol Med | 1955 | 13273400 | Yes |
| 2398 | 1507 | 1507.0 | 47.1 | 47.1 | Colorimetric determination of phospholipids with ammonium ferrothiocyanate. | J C Stewart | Anal Biochem | 1980 | 6892980 | Yes |
| 2399 | 1507 | 1507.0 | 47.4 | 47.4 | Targeting recovery: priorities of the spinal cord-injured population. | Kim D Anderson | J Neurotrauma | 2004 | 15672628 | Yes |
| 2400 | 1507 | 1507.0 | 0.0 | 0.0 | The colorimetric determination of phosphorus. | E J King | Biochem J | 1932 | 16744823 | Yes |
| 2401 | 3014 | 1507.0 | 66.8 | 33.4 | Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. | S W Hell, J Wichmann | Opt Lett | 1994 | 19844443 | Yes |
| 2402 | 3013 | 1506.5 | 79.2 | 39.6 | Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects. | R P Rao, D H Ballard | Nat Neurosci | 1999 | 10195184 | Yes |
| 2403 | 1506 | 1506.0 | 33.9 | 33.9 | Tumor suppressor genes. | R A Weinberg | Science | 1991 | 1659741 | No |
| 2404 | 1506 | 1506.0 | 61.9 | 61.9 | Likert scales, levels of measurement and the "laws" of statistics. | Geoff Norman | Adv Health Sci Educ Theory Pract | 2010 | 20146096 | Yes |
| 2405 | 1504 | 1504.0 | 44.6 | 44.6 | Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. | M D Maines | FASEB J | 1988 | 3290025 | No |
| 2406 | 3007 | 1503.5 | 64.2 | 32.1 | Chemokines: a new classification system and their role in immunity. | A Zlotnik, O Yoshie | Immunity | 2000 | 10714678 | No |
| 2407 | 3007 | 1503.5 | 61.3 | 30.6 | Of mice and not men: differences between mouse and human immunology. | Javier Mestas, Christopher C W Hughes | J Immunol | 2004 | 14978070 | No |
| 2408 | 3007 | 1503.5 | 99.1 | 49.5 | bold: The Barcode of Life Data System (http://www.barcodinglife.org). | Sujeevan Ratnasingham, Paul D N Hebert | Mol Ecol Notes | 2007 | 18784790 | Yes |
| 2409 | 1503 | 1503.0 | 39.6 | 39.6 | T follicular helper cell differentiation, function, and roles in disease. | Shane Crotty | Immunity | 2014 | 25367570 | No |
| 2410 | 3005 | 1502.5 | 85.8 | 42.9 | The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. | W L Jorgensen, J Tirado-Rives | J Am Chem Soc | 1988 | 27557051 | Yes |
| 2411 | 1502 | 1502.0 | 44.9 | 44.9 | Cytokinesis-block micronucleus cytome assay. | Michael Fenech | Nat Protoc | 2007 | 17546000 | Yes |
| 2412 | 1501 | 1501.0 | 55.4 | 55.4 | Lyme disease. | A C Steere | N Engl J Med | 1989 | 2668764 | No |
| 2413 | 1501 | 1501.0 | 62.6 | 62.6 | Human cardiovascular adjustments to exercise and thermal stress. | L B Rowell | Physiol Rev | 1974 | 4587247 | No |
| 2414 | 1501 | 1501.0 | 84.6 | 84.6 | A comparison of canal preparations in straight and curved root canals. | S W Schneider | Oral Surg Oral Med Oral Pathol | 1971 | 5284110 | Yes |
| 2415 | 4503 | 1501.0 | 127.0 | 42.3 | Bacterial biofilms: from the natural environment to infectious diseases. | Luanne Hall-Stoodley, J William Costerton, Paul Stoodley | Nat Rev Microbiol | 2004 | 15040259 | No |
| 2416 | 1501 | 1501.0 | 36.0 | 36.0 | Non-Smad pathways in TGF-beta signaling. | Ying E Zhang | Cell Res | 2009 | 19114990 | No |
| 2417 | 4502 | 1500.7 | 118.2 | 39.4 | LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. | A C Wallace, R A Laskowski, J M Thornton | Protein Eng | 1995 | 7630882 | Yes |
| 2418 | 1500 | 1500.0 | 41.8 | 41.8 | Rheumatoid arthritis. Pathophysiology and implications for therapy. | E D Harris | N Engl J Med | 1990 | 2271017 | No |
| 2419 | 1500 | 1500.0 | 73.6 | 73.6 | The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. | Martins Ekor | Front Pharmacol | 2014 | 24454289 | No |
| 2420 | 4497 | 1499.0 | 106.3 | 35.4 | Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. | Christian W Tornoe, Caspar Christensen, Morten Meldal | J Org Chem | 2002 | 11975567 | Yes |
| 2421 | 1499 | 1499.0 | 31.6 | 31.6 | Human natural killer cells. | Michael A Caligiuri | Blood | 2008 | 18650461 | No |
| 2422 | 1499 | 1499.0 | 45.6 | 45.6 | Thermal properties of graphene and nanostructured carbon materials. | Alexander A Balandin | Nat Mater | 2011 | 21778997 | Yes |
| 2423 | 2996 | 1498.0 | 77.8 | 38.9 | Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. | I Issemann, S Green | Nature | 1990 | 2129546 | Yes |
| 2424 | 1498 | 1498.0 | 0.0 | 0.0 | Dopamine (3-hydroxytyramine) and brain function. | O Hornykiewicz | Pharmacol Rev | 1966 | 5328389 | No |
| 2425 | 1498 | 1498.0 | 41.4 | 41.4 | Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. | Y Shai | Biochim Biophys Acta | 1999 | 10590302 | No |
| 2426 | 1498 | 1498.0 | 33.6 | 33.6 | Neurotrophins as synaptic modulators. | M M Poo | Nat Rev Neurosci | 2001 | 11253356 | No |
| 2427 | 1497 | 1497.0 | 0.0 | 0.0 | Potential, Impedance, And Rectification In Membranes. | D E Goldman | J Gen Physiol | 1943 | 19873371 | Yes |
| 2428 | 17962 | 1496.8 | 505.7 | 42.1 | Frailty in older adults: evidence for a phenotype. | L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnie, | J Gerontol A Biol Sci Med Sci | 2001 | 11253156 | Yes |
| 2429 | 2993 | 1496.5 | 89.2 | 44.6 | Antibiotic resistance of bacteria in biofilms. | P S Stewart, J W Costerton | Lancet | 2001 | 11463434 | No |
| 2430 | 2993 | 1496.5 | 72.9 | 36.5 | Regulation mechanisms and signaling pathways of autophagy. | Congcong He, Daniel J Klionsky | Annu Rev Genet | 2009 | 19653858 | No |
| 2431 | 1496 | 1496.0 | 34.5 | 34.5 | The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. | M Takeichi | Development | 1988 | 3048970 | No |
| 2432 | 1496 | 1496.0 | 54.0 | 54.0 | The biology and function of exosomes in cancer. | Raghu Kalluri | J Clin Invest | 2016 | 27035812 | No |
| 2433 | 2991 | 1495.5 | 101.1 | 50.5 | The efficiency of systematic sampling in stereology and its prediction. | H J Gundersen, E B Jensen | J Microsc | 1987 | 3430576 | Yes |
| 2434 | 2991 | 1495.5 | 76.8 | 38.4 | Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. | H Cai, D G Harrison | Circ Res | 2000 | 11073878 | No |
| 2435 | 2989 | 1494.5 | 132.6 | 66.3 | Principal component analysis: a review and recent developments. | Ian T Jolliffe, Jorge Cadima | Philos Trans A Math Phys Eng Sci | 2016 | 26953178 | No |
| 2436 | 1494 | 1494.0 | 34.6 | 34.6 | The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. | R G Khalifah | J Biol Chem | 1971 | 4994926 | Yes |
| 2437 | 1493 | 1493.0 | 108.8 | 108.8 | The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. | F C Ewald | Clin Orthop Relat Res | 1989 | 2805502 | Yes |
| 2438 | 1493 | 1493.0 | 0.0 | 0.0 | Defective repair replication of DNA in xeroderma pigmentosum. | J E Cleaver | Nature | 1968 | 5655953 | Yes |
| 2439 | 1493 | 1493.0 | 41.4 | 41.4 | Redox signaling: nitrosylation and related target interactions of nitric oxide. | J S Stamler | Cell | 1994 | 7923362 | No |
| 2440 | 4479 | 1493.0 | 0.0 | 0.0 | The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. | J T Dodge, C Mitchell, D J Hanahan | Arch Biochem Biophys | 1963 | 14028302 | Yes |
| 2441 | 1492 | 1492.0 | 34.1 | 34.1 | Target-oriented and diversity-oriented organic synthesis in drug discovery. | S L Schreiber | Science | 2000 | 10720315 | No |
| 2442 | 2984 | 1492.0 | 83.7 | 41.9 | The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. | Clay B Holroyd, Michael G H Coles | Psychol Rev | 2002 | 12374324 | Yes |
| 2443 | 1491 | 1491.0 | 43.5 | 43.5 | Mate selection-a selection for a handicap. | A Zahavi | J Theor Biol | 1975 | 1195756 | Yes |
| 2444 | 1491 | 1491.0 | 98.4 | 98.4 | A Review of Coronavirus Disease-2019 (COVID-19). | Tanu Singhal | Indian J Pediatr | 2020 | 32166607 | No |
| 2445 | 5960 | 1490.0 | 192.2 | 48.0 | A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. | M A Markwell, S M Haas, L L Bieber, N E Tolbert | Anal Biochem | 1978 | 98070 | Yes |
| 2446 | 2980 | 1490.0 | 61.6 | 30.8 | Prediction of complete gene structures in human genomic DNA. | C Burge, S Karlin | J Mol Biol | 1997 | 9149143 | Yes |
| 2447 | 1490 | 1490.0 | 34.3 | 34.3 | Protein misfolding, evolution and disease. | C M Dobson | Trends Biochem Sci | 1999 | 10470028 | No |
| 2448 | 5958 | 1489.5 | 293.7 | 73.4 | The Cambridge Structural Database. | Colin R Groom, Ian J Bruno, Matthew P Lightfoot, Suzanna C Ward | Acta Crystallogr B Struct Sci Cryst Eng Mater | 2016 | 27048719 | Yes |
| 2449 | 1489 | 1489.0 | 39.9 | 39.9 | The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. | A S Fauci | Science | 1988 | 3277274 | No |
| 2450 | 4466 | 1488.7 | 170.4 | 56.8 | Structure-antioxidant activity relationships of flavonoids and phenolic acids. | C A Rice-Evans, N J Miller, G Paganga | Free Radic Biol Med | 1996 | 8743980 | Yes |
| 2451 | 2977 | 1488.5 | 81.2 | 40.6 | Selective loss of central cholinergic neurons in Alzheimer's disease. | P Davies, A J Maloney | Lancet | 1976 | 63862 | Yes |
| 2452 | 1488 | 1488.0 | 33.6 | 33.6 | Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. | C Taswell | J Immunol | 1981 | 7009746 | Yes |
| 2453 | 1488 | 1488.0 | 44.7 | 44.7 | A note on robust variance estimation for cluster-correlated data. | R L Williams | Biometrics | 2000 | 10877330 | Yes |
| 2454 | 2976 | 1488.0 | 59.5 | 29.8 | Missing pieces in the NF-kappaB puzzle. | Sankar Ghosh, Michael Karin | Cell | 2002 | 11983155 | No |
| 2455 | 4464 | 1488.0 | 125.1 | 41.7 | Nitric oxide and peroxynitrite in health and disease. | Pal Pacher, Joseph S Beckman, Lucas Liaudet | Physiol Rev | 2007 | 17237348 | No |
| 2456 | 13391 | 1487.9 | 418.3 | 46.5 | The 1982 revised criteria for the classification of systemic lupus erythematosus. | E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester | Arthritis Rheum | 1982 | 7138600 | Yes |
| 2457 | 7433 | 1486.6 | 235.7 | 47.1 | Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939839 | Yes |
| 2458 | 1486 | 1486.0 | 0.0 | 0.0 | Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. | H E Huxley | J Mol Biol | 1963 | 14064165 | Yes |
| 2459 | 2972 | 1486.0 | 58.4 | 29.2 | Cancer genes and the pathways they control. | Bert Vogelstein, Kenneth W Kinzler | Nat Med | 2004 | 15286780 | No |
| 2460 | 4457 | 1485.7 | 98.7 | 32.9 | Multidrug resistance in cancer: role of ATP-dependent transporters. | Michael M Gottesman, Tito Fojo, Susan E Bates | Nat Rev Cancer | 2002 | 11902585 | No |
| 2461 | 2971 | 1485.5 | 76.0 | 38.0 | The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. | Daniel J Drucker, Michael A Nauck | Lancet | 2006 | 17098089 | No |
| 2462 | 1485 | 1485.0 | 38.9 | 38.9 | Cell and environment interactions in tumor microregions: the multicell spheroid model. | R M Sutherland | Science | 1988 | 2451290 | Yes |
| 2463 | 1485 | 1485.0 | 0.0 | 0.0 | Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. | S Avrameas | Immunochemistry | 1969 | 4975324 | Yes |
| 2464 | 1485 | 1485.0 | 65.5 | 65.5 | Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. | Helmut Sies | Redox Biol | 2017 | 28110218 | No |
| 2465 | 1485 | 1485.0 | 69.8 | 69.8 | Embracing the unknown: disentangling the complexities of the soil microbiome. | Noah Fierer | Nat Rev Microbiol | 2017 | 28824177 | No |
| 2466 | 1484 | 1484.0 | 57.4 | 57.4 | Starting at the beginning: an introduction to coefficient alpha and internal consistency. | David L Streiner | J Pers Assess | 2003 | 12584072 | Yes |
| 2467 | 1484 | 1484.0 | 0.0 | 0.0 | A modified ninhydrin colorimetric analysis for amino acids. | H Rosen | Arch Biochem Biophys | 1957 | 13412116 | Yes |
| 2468 | 4451 | 1483.7 | 95.5 | 31.8 | The versatility and universality of calcium signalling. | M J Berridge, P Lipp, M D Bootman | Nat Rev Mol Cell Biol | 2000 | 11413485 | No |
| 2469 | 1483 | 1483.0 | 29.7 | 29.7 | Nucleic acid junctions and lattices. | N C Seeman | J Theor Biol | 1982 | 6188926 | Yes |
| 2470 | 1483 | 1483.0 | 36.1 | 36.1 | PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. | B M Spiegelman | Diabetes | 1998 | 9568680 | No |
| 2471 | 1483 | 1483.0 | 0.0 | 0.0 | Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. | P C Nowell | Cancer Res | 1960 | 14427849 | Yes |
| 2472 | 1483 | 1483.0 | 71.4 | 71.4 | SARS-CoV-2 vaccines in development. | Florian Krammer | Nature | 2020 | 32967006 | No |
| 2473 | 1482 | 1482.0 | 42.7 | 42.7 | Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. | J A Beavo | Physiol Rev | 1995 | 7480160 | No |
| 2474 | 1482 | 1482.0 | 49.4 | 49.4 | Chronic disease management: what will it take to improve care for chronic illness? | E H Wagner | Eff Clin Pract | 1998 | 10345255 | No |
| 2475 | 2964 | 1482.0 | 58.5 | 29.2 | Wnt signalling in stem cells and cancer. | Tannishtha Reya, Hans Clevers | Nature | 2005 | 15829953 | No |
| 2476 | 2964 | 1482.0 | 113.7 | 56.9 | Natural products as sources of new drugs over the 30 years from 1981 to 2010. | David J Newman, Gordon M Cragg | J Nat Prod | 2012 | 22316239 | No |
| 2477 | 5928 | 1482.0 | 221.1 | 55.3 | Bayesian phylogenetics with BEAUti and the BEAST 1.7. | Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut | Mol Biol Evol | 2012 | 22367748 | Yes |
| 2478 | 1482 | 1482.0 | 61.5 | 61.5 | Overview of the IL-1 family in innate inflammation and acquired immunity. | Charles A Dinarello | Immunol Rev | 2018 | 29247995 | No |
| 2479 | 8891 | 1481.8 | 235.4 | 39.2 | An obesity-associated gut microbiome with increased capacity for energy harvest. | Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon | Nature | 2006 | 17183312 | Yes |
| 2480 | 2963 | 1481.5 | 55.3 | 27.6 | T-cell antigen receptor genes and T-cell recognition. | M M Davis, P J Bjorkman | Nature | 1988 | 3043226 | No |
| 2481 | 2963 | 1481.5 | 102.1 | 51.0 | Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. | D Filmer, L H Pritchett | Demography | 2001 | 11227840 | Yes |
| 2482 | 2963 | 1481.5 | 65.2 | 32.6 | LTP and LTD: an embarrassment of riches. | Robert C Malenka, Mark F Bear | Neuron | 2004 | 15450156 | No |
| 2483 | 1481 | 1481.0 | 45.8 | 45.8 | Neural simulation of action: a unifying mechanism for motor cognition. | M Jeannerod | Neuroimage | 2001 | 11373140 | No |
| 2484 | 5923 | 1480.8 | 210.1 | 52.5 | Predicting effective microRNA target sites in mammalian mRNAs. | Vikram Agarwal, George W Bell, Jin-Wu Nam, David P Bartel | Elife | 2015 | 26267216 | Yes |
| 2485 | 2961 | 1480.5 | 87.8 | 43.9 | Unidentified curved bacilli on gastric epithelium in active chronic gastritis. | J R Warren, B Marshall | Lancet | 1983 | 6134060 | Yes |
| 2486 | 2961 | 1480.5 | 71.1 | 35.5 | The MAPK signaling cascade. | R Seger, E G Krebs | FASEB J | 1995 | 7601337 | No |
| 2487 | 1480 | 1480.0 | 34.8 | 34.8 | Diarylethenes for Memories and Switches. | Masahiro Irie | Chem Rev | 2000 | 11777416 | Yes |
| 2488 | 8879 | 1479.8 | 241.4 | 40.2 | Genome engineering using the CRISPR-Cas9 system. | F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng Zhang | Nat Protoc | 2013 | 24157548 | Yes |
| 2489 | 2959 | 1479.5 | 0.0 | 0.0 | Brain stem reticular formation and activation of the EEG. | G Moruzzi, H W Magoun | Electroencephalogr Clin Neurophysiol | 1949 | 18421835 | Yes |
| 2490 | 2959 | 1479.5 | 82.2 | 41.1 | New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. | Jonathan B Baell, Georgina A Holloway | J Med Chem | 2010 | 20131845 | Yes |
| 2491 | 2959 | 1479.5 | 101.5 | 50.8 | Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. | Claudio Franceschi, Judith Campisi | J Gerontol A Biol Sci Med Sci | 2014 | 24833586 | No |
| 2492 | 8873 | 1478.8 | 246.7 | 41.1 | A default mode of brain function. | M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman | Proc Natl Acad Sci U S A | 2001 | 11209064 | Yes |
| 2493 | 1478 | 1478.0 | 64.6 | 64.6 | The clinical application of the biopsychosocial model. | G L Engel | Am J Psychiatry | 1980 | 7369396 | Yes |
| 2494 | 1478 | 1478.0 | 37.4 | 37.4 | A likelihood approach to estimating phylogeny from discrete morphological character data. | P O Lewis | Syst Biol | 2001 | 12116640 | Yes |
| 2495 | 4434 | 1478.0 | 281.2 | 93.7 | How to perform a meta-analysis with R: a practical tutorial. | Sara Balduzzi, Gerta Rucker, Guido Schwarzer | Evid Based Ment Health | 2019 | 31563865 | Yes |
| 2496 | 2955 | 1477.5 | 57.9 | 28.9 | STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. | Hiroki Ishikawa, Glen N Barber | Nature | 2008 | 18724357 | Yes |
| 2497 | 1477 | 1477.0 | 33.6 | 33.6 | The ATP synthase--a splendid molecular machine. | P D Boyer | Annu Rev Biochem | 1997 | 9242922 | No |
| 2498 | 1477 | 1477.0 | 70.4 | 70.4 | Patient reported outcome measures could help transform healthcare. | Nick Black | BMJ | 2013 | 23358487 | Yes |
| 2499 | 2952 | 1476.0 | 75.2 | 37.6 | C-reactive protein: a critical update. | Mark B Pepys, Gideon M Hirschfield | J Clin Invest | 2003 | 12813013 | No |
| 2500 | 1476 | 1476.0 | 33.8 | 33.8 | Transcriptional control of adipocyte formation. | Stephen R Farmer | Cell Metab | 2006 | 17011499 | No |
| 2501 | 2952 | 1476.0 | 112.2 | 56.1 | Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. | Ulrich M Zanger, Matthias Schwab | Pharmacol Ther | 2013 | 23333322 | No |
| 2502 | 2951 | 1475.5 | 0.0 | 0.0 | The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. | E G Gray, V P Whittaker | J Anat | 1962 | 13901297 | Yes |
| 2503 | 1475 | 1475.0 | 37.2 | 37.2 | Drug-induced prolongation of the QT interval. | Dan M Roden | N Engl J Med | 2004 | 14999113 | No |
| 2504 | 2949 | 1474.5 | 73.2 | 36.6 | Inflammation, stress, and diabetes. | Kathryn E Wellen, Gokhan S Hotamisligil | J Clin Invest | 2005 | 15864338 | No |
| 2505 | 1474 | 1474.0 | 33.3 | 33.3 | Ionic blockage of sodium channels in nerve. | A M Woodhull | J Gen Physiol | 1973 | 4541078 | Yes |
| 2506 | 1474 | 1474.0 | 0.0 | 0.0 | Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. | K S McCully | Am J Pathol | 1969 | 5792556 | Yes |
| 2507 | 1474 | 1474.0 | 50.1 | 50.1 | The epidemiology of adult obstructive sleep apnea. | Naresh M Punjabi | Proc Am Thorac Soc | 2008 | 18250205 | No |
| 2508 | 2946 | 1473.0 | 64.9 | 32.5 | A general method for isolation of high molecular weight DNA from eukaryotes. | N Blin, D W Stafford | Nucleic Acids Res | 1976 | 987581 | Yes |
| 2509 | 1473 | 1473.0 | 0.0 | 0.0 | A clinical method for assessing the ventilatory response to carbon dioxide. | D J Read | Australas Ann Med | 1967 | 6032026 | Yes |
| 2510 | 1473 | 1473.0 | 27.5 | 27.5 | The DNA methyltransferases of mammals. | T H Bestor | Hum Mol Genet | 2000 | 11005794 | No |
| 2511 | 1473 | 1473.0 | 29.9 | 29.9 | Natively unfolded proteins: a point where biology waits for physics. | Vladimir N Uversky | Protein Sci | 2002 | 11910019 | No |
| 2512 | 1473 | 1473.0 | 51.1 | 51.1 | Electrolytes and interphases in Li-ion batteries and beyond. | Kang Xu | Chem Rev | 2014 | 25351820 | Yes |
| 2513 | 4418 | 1472.7 | 146.3 | 48.8 | Global estimates of the prevalence of diabetes for 2010 and 2030. | J E Shaw, R A Sicree, P Z Zimmet | Diabetes Res Clin Pract | 2010 | 19896746 | Yes |
| 2514 | 1472 | 1472.0 | 0.0 | 0.0 | The origin of the genetic code. | F H Crick | J Mol Biol | 1968 | 4887876 | Yes |
| 2515 | 1472 | 1472.0 | 42.0 | 42.0 | The aging process. | D Harman | Proc Natl Acad Sci U S A | 1981 | 6947277 | Yes |
| 2516 | 1472 | 1472.0 | 0.0 | 0.0 | The free amino groups of insulin. | F Sanger | Biochem J | 1945 | 16747948 | Yes |
| 2517 | 4415 | 1471.7 | 103.2 | 34.4 | Photodynamic therapy for cancer. | Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain | Nat Rev Cancer | 2003 | 12724736 | No |
| 2518 | 5885 | 1471.2 | 157.4 | 39.4 | Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. | Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu Miyasaka | J Am Chem Soc | 2009 | 19366264 | Yes |
| 2519 | 1470 | 1470.0 | 0.0 | 0.0 | The critical incident technique. | J C Flanagan | Psychol Bull | 1954 | 13177800 | Yes |
| 2520 | 4408 | 1469.3 | 136.1 | 45.4 | TCS: a computer program to estimate gene genealogies. | M Clement, D Posada, K A Crandall | Mol Ecol | 2000 | 11050560 | Yes |
| 2521 | 2937 | 1468.5 | 86.3 | 43.1 | Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. | F D Lublin, S C Reingold | Neurology | 1996 | 8780061 | Yes |
| 2522 | 10277 | 1468.1 | 316.5 | 45.2 | Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. | H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh | Stroke | 1993 | 7678184 | Yes |
| 2523 | 4404 | 1468.0 | 216.8 | 72.3 | Risk factors for falls among elderly persons living in the community. | M E Tinetti, M Speechley, S F Ginter | N Engl J Med | 1988 | 3205267 | Yes |
| 2524 | 2936 | 1468.0 | 86.5 | 43.2 | Epidemiology of invasive candidiasis: a persistent public health problem. | M A Pfaller, D J Diekema | Clin Microbiol Rev | 2007 | 17223626 | No |
| 2525 | 1468 | 1468.0 | 43.8 | 43.8 | Endometriosis. | Serdar E Bulun | N Engl J Med | 2009 | 19144942 | No |
| 2526 | 1468 | 1468.0 | 44.5 | 44.5 | Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. | Chao-Jun Li | Acc Chem Res | 2009 | 19220064 | Yes |
| 2527 | 1468 | 1468.0 | 50.1 | 50.1 | The frailty syndrome: definition and natural history. | Qian-Li Xue | Clin Geriatr Med | 2011 | 21093718 | No |
| 2528 | 5872 | 1468.0 | 166.3 | 41.6 | GCTA: a tool for genome-wide complex trait analysis. | Jian Yang, S Hong Lee, Michael E Goddard, Peter M Visscher | Am J Hum Genet | 2011 | 21167468 | Yes |
| 2529 | 2935 | 1467.5 | 63.7 | 31.9 | The canonical Notch signaling pathway: unfolding the activation mechanism. | Raphael Kopan, Maria Xenia G Ilagan | Cell | 2009 | 19379690 | No |
| 2530 | 2934 | 1467.0 | 93.0 | 46.5 | The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. | J D Hayes, D J Pulford | Crit Rev Biochem Mol Biol | 1995 | 8770536 | No |
| 2531 | 2934 | 1467.0 | 68.4 | 34.2 | The pathophysiology and treatment of sepsis. | Richard S Hotchkiss, Irene E Karl | N Engl J Med | 2003 | 12519925 | No |
| 2532 | 1467 | 1467.0 | 56.1 | 56.1 | A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. | Cathy J Price | Neuroimage | 2012 | 22584224 | No |
| 2533 | 1467 | 1467.0 | 85.5 | 85.5 | Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. | Jonas F Ludvigsson | Acta Paediatr | 2020 | 32202343 | Yes |
| 2534 | 2933 | 1466.5 | 85.7 | 42.9 | Mitochondrial fission, fusion, and stress. | Richard J Youle, Alexander M Van Der Bliek | Science | 2012 | 22936770 | No |
| 2535 | 2931 | 1465.5 | 0.0 | 0.0 | Virus interference. I. The interferon. | A Isaacs, J Lindenmann | Proc R Soc Lond B Biol Sci | 1957 | 13465720 | Yes |
| 2536 | 2930 | 1465.0 | 89.4 | 44.7 | Mechanisms of fibrosis: therapeutic translation for fibrotic disease. | Thomas A Wynn, Thirumalai R Ramalingam | Nat Med | 2012 | 22772564 | No |
| 2537 | 5860 | 1465.0 | 251.2 | 62.8 | Prevalence of childhood and adult obesity in the United States, 2011-2012. | Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M Flegal | JAMA | 2014 | 24570244 | Yes |
| 2538 | 1465 | 1465.0 | 87.4 | 87.4 | Critical Analysis of Strategies for Determining Rigor in Qualitative Inquiry. | Janice M Morse | Qual Health Res | 2015 | 26184336 | Yes |
| 2539 | 2929 | 1464.5 | 88.1 | 44.0 | Opportunities and challenges for a sustainable energy future. | Steven Chu, Arun Majumdar | Nature | 2012 | 22895334 | No |
| 2540 | 2928 | 1464.0 | 69.6 | 34.8 | Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. | E Engvall, P Perlmann | Immunochemistry | 1971 | 5135623 | Yes |
| 2541 | 1464 | 1464.0 | 35.9 | 35.9 | Binary Agrobacterium vectors for plant transformation. | M Bevan | Nucleic Acids Res | 1984 | 6095209 | Yes |
| 2542 | 1464 | 1464.0 | 0.0 | 0.0 | Simple methods for "staining with lead" at high pH in electron microscopy. | M J Karnovsky | J Biophys Biochem Cytol | 1961 | 14454024 | Yes |
| 2543 | 2928 | 1464.0 | 75.7 | 37.9 | Integrins in cancer: biological implications and therapeutic opportunities. | Jay S Desgrosellier, David A Cheresh | Nat Rev Cancer | 2010 | 20029421 | No |
| 2544 | 2927 | 1463.5 | 80.3 | 40.1 | The expanding universe of T-cell subsets: Th1, Th2 and more. | T R Mosmann, S Sad | Immunol Today | 1996 | 8820272 | No |
| 2545 | 2926 | 1463.0 | 127.6 | 63.8 | Cronbach's alpha. | J M Bland, D G Altman | BMJ | 1997 | 9055718 | Yes |
| 2546 | 2926 | 1463.0 | 56.7 | 28.4 | Oncogenic kinase signalling. | P Blume-Jensen, T Hunter | Nature | 2001 | 11357143 | No |
| 2547 | 1463 | 1463.0 | 41.2 | 41.2 | Comparative physiology of salt and water stress. | R Munns | Plant Cell Environ | 2002 | 11841667 | Yes |
| 2548 | 1462 | 1462.0 | 21.0 | 21.0 | Central dogma of molecular biology. | F Crick | Nature | 1970 | 4913914 | No |
| 2549 | 1462 | 1462.0 | 56.4 | 56.4 | Presidential address, 1980. Surprise!...Surprise? | E Donchin | Psychophysiology | 1981 | 7280146 | Yes |
| 2550 | 1462 | 1462.0 | 44.5 | 44.5 | Persister cells. | Kim Lewis | Annu Rev Microbiol | 2010 | 20528688 | No |
| 2551 | 2924 | 1462.0 | 105.6 | 52.8 | Unique features of long non-coding RNA biogenesis and function. | Jeffrey J Quinn, Howard Y Chang | Nat Rev Genet | 2016 | 26666209 | No |
| 2552 | 2922 | 1461.0 | 83.0 | 41.5 | Assay of proteins in the presence of interfering materials. | A Bensadoun, D Weinstein | Anal Biochem | 1976 | 1259145 | Yes |
| 2553 | 2922 | 1461.0 | 0.0 | 0.0 | Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. | A Dahlstroem, K Fuxe | Acta Physiol Scand Suppl | 1964 | 14229500 | Yes |
| 2554 | 1461 | 1461.0 | 0.0 | 0.0 | Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. | I E Bush | Biochem J | 1952 | 14915960 | Yes |
| 2555 | 2922 | 1461.0 | 72.7 | 36.4 | Microglia: active sensor and versatile effector cells in the normal and pathologic brain. | Uwe-Karsten Hanisch, Helmut Kettenmann | Nat Neurosci | 2007 | 17965659 | No |
| 2556 | 2921 | 1460.5 | 61.0 | 30.5 | Learning the parts of objects by non-negative matrix factorization. | D D Lee, H S Seung | Nature | 1999 | 10548103 | Yes |
| 2557 | 1460 | 1460.0 | 34.2 | 34.2 | Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. | S S Lehrer | Biochemistry | 1971 | 5119250 | Yes |
| 2558 | 1460 | 1460.0 | 42.3 | 42.3 | Isolation and cultivation of Lyme disease spirochetes. | A G Barbour | Yale J Biol Med | 1984 | 6393604 | Yes |
| 2559 | 1460 | 1460.0 | 38.4 | 38.4 | Tobacco smoke carcinogens and lung cancer. | S S Hecht | J Natl Cancer Inst | 1999 | 10413421 | No |
| 2560 | 1459 | 1459.0 | 0.0 | 0.0 | Hippocampal electrical activity and voluntary movement in the rat. | C H Vanderwolf | Electroencephalogr Clin Neurophysiol | 1969 | 4183562 | Yes |
| 2561 | 1458 | 1458.0 | 34.3 | 34.3 | Developmental cell death: morphological diversity and multiple mechanisms. | P G Clarke | Anat Embryol (Berl) | 1990 | 2186664 | No |
| 2562 | 1458 | 1458.0 | 43.3 | 43.3 | The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. | R G Pertwee | Br J Pharmacol | 2008 | 17828291 | No |
| 2563 | 2913 | 1456.5 | 59.9 | 29.9 | 3' non-coding region sequences in eukaryotic messenger RNA. | N J Proudfoot, G G Brownlee | Nature | 1976 | 822353 | Yes |
| 2564 | 2913 | 1456.5 | 72.7 | 36.4 | Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. | E S Lander, D Botstein | Genetics | 1989 | 2563713 | Yes |
| 2565 | 1456 | 1456.0 | 78.0 | 78.0 | Displaced proximal humeral fractures. I. Classification and evaluation. | C S Neer | J Bone Joint Surg Am | 1970 | 5455339 | Yes |
| 2566 | 2911 | 1455.5 | 0.0 | 0.0 | Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. | D H Clarke, J Casals | Am J Trop Med Hyg | 1958 | 13571577 | Yes |
| 2567 | 1455 | 1455.0 | 52.8 | 52.8 | Quantitative methods in the review of epidemiologic literature. | S Greenland | Epidemiol Rev | 1987 | 3678409 | Yes |
| 2568 | 1455 | 1455.0 | 27.6 | 27.6 | ChIP-seq: advantages and challenges of a maturing technology. | Peter J Park | Nat Rev Genet | 2009 | 19736561 | No |
| 2569 | 1454 | 1454.0 | 42.4 | 42.4 | The organization of proteins in the human red blood cell membrane. A review. | T L Steck | J Cell Biol | 1974 | 4600883 | No |
| 2570 | 1454 | 1454.0 | 44.9 | 44.9 | Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. | P Willner | Psychopharmacology (Berl) | 1997 | 9452163 | No |
| 2571 | 2908 | 1454.0 | 88.9 | 44.5 | Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. | J A Sterne, M Egger | J Clin Epidemiol | 2001 | 11576817 | Yes |
| 2572 | 1454 | 1454.0 | 36.0 | 36.0 | Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? | Rui Wang | FASEB J | 2002 | 12409322 | Yes |
| 2573 | 1454 | 1454.0 | 68.3 | 68.3 | Body Mass Index: Obesity, BMI, and Health: A Critical Review. | Frank Q Nuttall | Nutr Today | 2015 | 27340299 | Yes |
| 2574 | 2907 | 1453.5 | 117.2 | 58.6 | Malondialdehyde determination as index of lipid peroxidation. | H H Draper, M Hadley | Methods Enzymol | 1990 | 2233309 | Yes |
| 2575 | 2907 | 1453.5 | 73.8 | 36.9 | Molecular beacons: probes that fluoresce upon hybridization. | S Tyagi, F R Kramer | Nat Biotechnol | 1996 | 9630890 | Yes |
| 2576 | 1453 | 1453.0 | 29.9 | 29.9 | Solving structures of protein complexes by molecular replacement with Phaser. | Airlie J McCoy | Acta Crystallogr D Biol Crystallogr | 2007 | 17164524 | Yes |
| 2577 | 2904 | 1452.0 | 185.0 | 92.5 | Facial nerve grading system. | J W House, D E Brackmann | Otolaryngol Head Neck Surg | 1985 | 3921901 | Yes |
| 2578 | 2904 | 1452.0 | 80.4 | 40.2 | A rapid boiling method for the preparation of bacterial plasmids. | D S Holmes, M Quigley | Anal Biochem | 1981 | 6269464 | Yes |
| 2579 | 1452 | 1452.0 | 53.8 | 53.8 | Plasma perspective on strong field multiphoton ionization. | P B Corkum | Phys Rev Lett | 1993 | 10054556 | Yes |
| 2580 | 1451 | 1451.0 | 27.2 | 27.2 | Ubiquitin-dependent protein degradation. | M Hochstrasser | Annu Rev Genet | 1996 | 8982460 | No |
| 2581 | 2902 | 1451.0 | 0.0 | 0.0 | Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. | H J Bloom, W W Richardson | Br J Cancer | 1957 | 13499785 | Yes |
| 2582 | 1451 | 1451.0 | 32.1 | 32.1 | A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. | Dale R Nyholt | Am J Hum Genet | 2004 | 14997420 | Yes |
| 2583 | 2902 | 1451.0 | 131.4 | 65.7 | Inflammation and Cancer: Triggers, Mechanisms, and Consequences. | Florian R Greten, Sergei I Grivennikov | Immunity | 2019 | 31315034 | No |
| 2584 | 7254 | 1450.8 | 268.9 | 53.8 | The Phyre2 web portal for protein modeling, prediction and analysis. | Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E Sternberg | Nat Protoc | 2015 | 25950237 | Yes |
| 2585 | 4351 | 1450.3 | 111.1 | 37.0 | Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. | Daniel Falush, Matthew Stephens, Jonathan K Pritchard | Genetics | 2003 | 12930761 | Yes |
| 2586 | 2900 | 1450.0 | 82.7 | 41.4 | Angiogenesis. | J Folkman, Y Shing | J Biol Chem | 1992 | 1375931 | No |
| 2587 | 1449 | 1449.0 | 36.8 | 36.8 | General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. | R A Houghten | Proc Natl Acad Sci U S A | 1985 | 2410914 | Yes |
| 2588 | 2898 | 1449.0 | 73.0 | 36.5 | Quorum sensing in bacteria. | M B Miller, B L Bassler | Annu Rev Microbiol | 2001 | 11544353 | No |
| 2589 | 2898 | 1449.0 | 77.6 | 38.8 | Therapeutic potential of resveratrol: the in vivo evidence. | Joseph A Baur, David A Sinclair | Nat Rev Drug Discov | 2006 | 16732220 | No |
| 2590 | 1449 | 1449.0 | 46.8 | 46.8 | Understanding diagnostic tests 3: Receiver operating characteristic curves. | Anthony K Akobeng | Acta Paediatr | 2007 | 17376185 | No |
| 2591 | 2896 | 1448.0 | 60.5 | 30.2 | Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. | C Auffray, F Rougeon | Eur J Biochem | 1980 | 6772444 | Yes |
| 2592 | 1448 | 1448.0 | 29.2 | 29.2 | Mechanisms of caspase activation and inhibition during apoptosis. | Yigong Shi | Mol Cell | 2002 | 11931755 | No |
| 2593 | 4344 | 1448.0 | 115.6 | 38.5 | Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. | S Schulman, C Kearon, | J Thromb Haemost | 2005 | 15842354 | Yes |
| 2594 | 1448 | 1448.0 | 45.5 | 45.5 | Clinical practice. Endometriosis. | Linda C Giudice | N Engl J Med | 2010 | 20573927 | No |
| 2595 | 2895 | 1447.5 | 86.9 | 43.5 | The Measurement Of Selection On Correlated Characters. | Russell Lande, Stevan J Arnold | Evolution | 1983 | 28556011 | Yes |
| 2596 | 2894 | 1447.0 | 73.6 | 36.8 | Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. | M D Pierschbacher, E Ruoslahti | Nature | 1984 | 6325925 | Yes |
| 2597 | 2893 | 1446.5 | 66.4 | 33.2 | The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. | P M Sharp, W H Li | Nucleic Acids Res | 1987 | 3547335 | Yes |
| 2598 | 2893 | 1446.5 | 0.0 | 0.0 | Mutants of Escherichia coli requiring methionine or vitamin B12. | B D Davis, E S Mingioli | J Bacteriol | 1950 | 15436457 | Yes |
| 2599 | 4339 | 1446.3 | 104.4 | 34.8 | Tissue cells feel and respond to the stiffness of their substrate. | Dennis E Discher, Paul Janmey, Yu-Li Wang | Science | 2005 | 16293750 | No |
| 2600 | 5785 | 1446.2 | 202.8 | 50.7 | The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. | L A Sternberger, P H Hardy, J J Cuculis, H G Meyer | J Histochem Cytochem | 1970 | 4192899 | Yes |
| 2601 | 1446 | 1446.0 | 50.2 | 50.2 | Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. | G A McPherson | J Pharmacol Methods | 1985 | 3840547 | Yes |
| 2602 | 1446 | 1446.0 | 22.6 | 22.6 | Origin of concatemeric T7 DNA. | J D Watson | Nat New Biol | 1972 | 4507727 | Yes |
| 2603 | 2892 | 1446.0 | 73.7 | 36.9 | Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. | M P Lutolf, J A Hubbell | Nat Biotechnol | 2005 | 15637621 | No |
| 2604 | 1446 | 1446.0 | 40.0 | 40.0 | Atopic dermatitis. | Thomas Bieber | N Engl J Med | 2008 | 18385500 | Yes |
| 2605 | 1446 | 1446.0 | 49.5 | 49.5 | Energy metabolism in the liver. | Liangyou Rui | Compr Physiol | 2014 | 24692138 | No |
| 2606 | 2890 | 1445.0 | 102.3 | 51.1 | Modeling and comparison of dissolution profiles. | P Costa, J M Sousa Lobo | Eur J Pharm Sci | 2001 | 11297896 | No |
| 2607 | 1445 | 1445.0 | 34.6 | 34.6 | Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. | Hiroshi Takayanagi | Nat Rev Immunol | 2007 | 17380158 | No |
| 2608 | 1445 | 1445.0 | 30.7 | 30.7 | Neuroligins and neurexins link synaptic function to cognitive disease. | Thomas C Sudhof | Nature | 2008 | 18923512 | No |
| 2609 | 2889 | 1444.5 | 90.6 | 45.3 | Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9164317 | Yes |
| 2610 | 1444 | 1444.0 | 42.9 | 42.9 | Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. | P Lips | Endocr Rev | 2001 | 11493580 | No |
| 2611 | 1444 | 1444.0 | 0.0 | 0.0 | Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. | J Wyman | Adv Protein Chem | 1964 | 14268785 | No |
| 2612 | 1444 | 1444.0 | 36.3 | 36.3 | The use of nanocrystals in biological detection. | Paul Alivisatos | Nat Biotechnol | 2004 | 14704706 | Yes |
| 2613 | 1444 | 1444.0 | 32.5 | 32.5 | Simple model of spiking neurons. | E M Izhikevich | IEEE Trans Neural Netw | 2003 | 18244602 | Yes |
| 2614 | 7217 | 1443.4 | 159.0 | 31.8 | Site-directed mutagenesis by overlap extension using the polymerase chain reaction. | S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease | Gene | 1989 | 2744487 | Yes |
| 2615 | 1443 | 1443.0 | 38.1 | 38.1 | Capacitative calcium entry revisited. | J W Putney | Cell Calcium | 1990 | 1965707 | No |
| 2616 | 1443 | 1443.0 | 43.5 | 43.5 | Core affect and the psychological construction of emotion. | James A Russell | Psychol Rev | 2003 | 12529060 | No |
| 2617 | 1443 | 1443.0 | 39.5 | 39.5 | The sympathetic control of blood pressure. | Patrice G Guyenet | Nat Rev Neurosci | 2006 | 16760914 | No |
| 2618 | 1442 | 1442.0 | 32.3 | 32.3 | HIF-1: mediator of physiological and pathophysiological responses to hypoxia. | G L Semenza | J Appl Physiol (1985) | 2000 | 10749844 | No |
| 2619 | 2884 | 1442.0 | 0.0 | 0.0 | A new scale of social desirability independent of psychopathology. | D P Crowne, D Marlowe | J Consult Psychol | 1960 | 13813058 | Yes |
| 2620 | 1442 | 1442.0 | 29.9 | 29.9 | Stability and flexibility of epigenetic gene regulation in mammalian development. | Wolf Reik | Nature | 2007 | 17522676 | No |
| 2621 | 5766 | 1441.5 | 160.7 | 40.2 | The metabolic syndrome--a new worldwide definition. | K George M M Alberti, Paul Zimmet, Jonathan Shaw, | Lancet | 2005 | 16182882 | Yes |
| 2622 | 4324 | 1441.3 | 87.5 | 29.2 | Exosomes: composition, biogenesis and function. | Clotilde Thery, Laurence Zitvogel, Sebastian Amigorena | Nat Rev Immunol | 2002 | 12154376 | No |
| 2623 | 1441 | 1441.0 | 49.7 | 49.7 | Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. | N Krieger | Am J Public Health | 1992 | 1566949 | Yes |
| 2624 | 1441 | 1441.0 | 34.7 | 34.7 | Metastatic bone disease: clinical features, pathophysiology and treatment strategies. | R E Coleman | Cancer Treat Rev | 2001 | 11417967 | No |
| 2625 | 2882 | 1441.0 | 0.0 | 0.0 | A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. | A H Anton, D F Sayre | J Pharmacol Exp Ther | 1962 | 14013351 | Yes |
| 2626 | 1441 | 1441.0 | 46.5 | 46.5 | Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. | Rui Wang | Physiol Rev | 2012 | 22535897 | No |
| 2627 | 2882 | 1441.0 | 122.7 | 61.4 | Designing hydrogels for controlled drug delivery. | Jianyu Li, David J Mooney | Nat Rev Mater | 2016 | 29657852 | Yes |
| 2628 | 2880 | 1440.0 | 76.6 | 38.3 | Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. | Taro Kawai, Shizuo Akira | Immunity | 2011 | 21616434 | No |
| 2629 | 4318 | 1439.3 | 91.9 | 30.6 | Calcium signalling: dynamics, homeostasis and remodelling. | Michael J Berridge, Martin D Bootman, H Llewelyn Roderick | Nat Rev Mol Cell Biol | 2003 | 12838335 | No |
| 2630 | 1439 | 1439.0 | 0.0 | 0.0 | The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. | R C Lewontin | Genetics | 1964 | 17248194 | Yes |
| 2631 | 2877 | 1438.5 | 0.0 | 0.0 | Construct validity in psychological tests. | L J Cronbach, P E Meehl | Psychol Bull | 1955 | 13245896 | Yes |
| 2632 | 2877 | 1438.5 | 135.4 | 67.7 | An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. | Jesper L R Andersson, Stamatios N Sotiropoulos | Neuroimage | 2016 | 26481672 | Yes |
| 2633 | 1438 | 1438.0 | 25.9 | 25.9 | The snail superfamily of zinc-finger transcription factors. | M Angela Nieto | Nat Rev Mol Cell Biol | 2002 | 11994736 | No |
| 2634 | 1438 | 1438.0 | 41.6 | 41.6 | Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. | P Vestergaard | Osteoporos Int | 2007 | 17068657 | No |
| 2635 | 1437 | 1437.0 | 34.8 | 34.8 | Physiological and molecular basis of thyroid hormone action. | P M Yen | Physiol Rev | 2001 | 11427693 | No |
| 2636 | 1437 | 1437.0 | 0.0 | 0.0 | Starch gel electrophoresis in a discontinous system of buffers. | M D Poulik | Nature | 1957 | 13493570 | Yes |
| 2637 | 4309 | 1436.3 | 129.6 | 43.2 | A rapid bootstrap algorithm for the RAxML Web servers. | Alexandros Stamatakis, Paul Hoover, Jacques Rougemont | Syst Biol | 2008 | 18853362 | Yes |
| 2638 | 7180 | 1436.0 | 138.7 | 27.7 | Crystal structure of the nucleosome core particle at 2.8 A resolution. | K Luger, A W Mader, R K Richmond, D F Sargent, T J Richmond | Nature | 1997 | 9305837 | Yes |
| 2639 | 1436 | 1436.0 | 38.8 | 38.8 | Pain and emotion interactions in subregions of the cingulate gyrus. | Brent A Vogt | Nat Rev Neurosci | 2005 | 15995724 | No |
| 2640 | 1436 | 1436.0 | 60.2 | 60.2 | Mediation Analysis: A Practitioner's Guide. | Tyler J VanderWeele | Annu Rev Public Health | 2016 | 26653405 | No |
| 2641 | 2871 | 1435.5 | 84.4 | 42.2 | Intracellular pH. | A Roos, W F Boron | Physiol Rev | 1981 | 7012859 | No |
| 2642 | 1435 | 1435.0 | 39.1 | 39.1 | Deconvoluting the context-dependent role for autophagy in cancer. | Eileen White | Nat Rev Cancer | 2012 | 22534666 | No |
| 2643 | 2870 | 1435.0 | 94.9 | 47.5 | A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. | Walter J Paulus, Carsten Tschope | J Am Coll Cardiol | 2013 | 23684677 | No |
| 2644 | 1434 | 1434.0 | 27.7 | 27.7 | The biologic clock: the mitochondria? | D Harman | J Am Geriatr Soc | 1972 | 5016631 | Yes |
| 2645 | 1434 | 1434.0 | 34.6 | 34.6 | Functions of ceramide in coordinating cellular responses to stress. | Y A Hannun | Science | 1996 | 8943189 | No |
| 2646 | 4302 | 1434.0 | 96.3 | 32.1 | NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. | S Ghosh, M J May, E B Kopp | Annu Rev Immunol | 1998 | 9597130 | No |
| 2647 | 1434 | 1434.0 | 39.1 | 39.1 | Persister cells, dormancy and infectious disease. | Kim Lewis | Nat Rev Microbiol | 2007 | 17143318 | No |
| 2648 | 1434 | 1434.0 | 177.8 | 177.8 | Ultrafast one-pass FASTQ data preprocessing, quality control, and deduplication using fastp. | Shifu Chen | Imeta | 2023 | 38868435 | Yes |
| 2649 | 4300 | 1433.3 | 144.1 | 48.0 | Vascular endothelial cells synthesize nitric oxide from L-arginine. | R M Palmer, D S Ashton, S Moncada | Nature | 1988 | 3131684 | Yes |
| 2650 | 4300 | 1433.3 | 137.1 | 45.7 | Health benefits of physical activity: the evidence. | Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin | CMAJ | 2006 | 16534088 | No |
| 2651 | 2866 | 1433.0 | 0.0 | 0.0 | The effect of sodium ions on the electrical activity of giant axon of the squid. | A L Hodgkin, B Katz | J Physiol | 1949 | 18128147 | Yes |
| 2652 | 2865 | 1432.5 | 82.2 | 41.1 | Transforming growth factor beta in tissue fibrosis. | W A Border, N A Noble | N Engl J Med | 1994 | 7935686 | No |
| 2653 | 1432 | 1432.0 | 26.8 | 26.8 | Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. | J C Unkeless | J Exp Med | 1979 | 90108 | Yes |
| 2654 | 1432 | 1432.0 | 34.9 | 34.9 | Molecular basis of long-term plasticity underlying addiction. | E J Nestler | Nat Rev Neurosci | 2001 | 11252991 | No |
| 2655 | 4294 | 1431.3 | 106.7 | 35.6 | Functional porous coordination polymers. | Susumu Kitagawa, Ryo Kitaura, Shin-Ichiro Noro | Angew Chem Int Ed Engl | 2004 | 15114565 | Yes |
| 2656 | 1431 | 1431.0 | 34.4 | 34.4 | Regulation of differentiation of vascular smooth muscle cells. | G K Owens | Physiol Rev | 1995 | 7624392 | No |
| 2657 | 1431 | 1431.0 | 26.8 | 26.8 | c-Myc target genes involved in cell growth, apoptosis, and metabolism. | C V Dang | Mol Cell Biol | 1999 | 9858526 | No |
| 2658 | 1431 | 1431.0 | 37.5 | 37.5 | Microbial influences in inflammatory bowel diseases. | R Balfour Sartor | Gastroenterology | 2008 | 18242222 | No |
| 2659 | 4293 | 1431.0 | 107.5 | 35.8 | Improved vectors and genome-wide libraries for CRISPR screening. | Neville E Sanjana, Ophir Shalem, Feng Zhang | Nat Methods | 2014 | 25075903 | Yes |
| 2660 | 4290 | 1430.0 | 123.9 | 41.3 | Cognitive and emotional influences in anterior cingulate cortex. | G Bush, P Luu, M I Posner | Trends Cogn Sci | 2000 | 10827444 | Yes |
| 2661 | 1430 | 1430.0 | 35.8 | 35.8 | The prefrontal cortex and cognitive control. | E K Miller | Nat Rev Neurosci | 2000 | 11252769 | No |
| 2662 | 2859 | 1429.5 | 106.3 | 53.1 | Tumour heterogeneity and resistance to cancer therapies. | Ibiayi Dagogo-Jack, Alice T Shaw | Nat Rev Clin Oncol | 2018 | 29115304 | No |
| 2663 | 2857 | 1428.5 | 100.3 | 50.1 | Total energy intake: implications for epidemiologic analyses. | W Willett, M J Stampfer | Am J Epidemiol | 1986 | 3521261 | No |
| 2664 | 1428 | 1428.0 | 43.6 | 43.6 | Classification of chronic viral hepatitis: a need for reassessment. | P J Scheuer | J Hepatol | 1991 | 1808228 | No |
| 2665 | 1428 | 1428.0 | 77.5 | 77.5 | Psychosocial resilience and protective mechanisms. | Michael Rutter | Am J Orthopsychiatry | 1987 | 3303954 | No |
| 2666 | 4284 | 1428.0 | 90.4 | 30.1 | Computer visualization of three-dimensional image data using IMOD. | J R Kremer, D N Mastronarde, J R McIntosh | J Struct Biol | 1996 | 8742726 | Yes |
| 2667 | 1428 | 1428.0 | 29.9 | 29.9 | Searching for intellectual turning points: progressive knowledge domain visualization. | Chaomei Chen | Proc Natl Acad Sci U S A | 2004 | 14724295 | Yes |
| 2668 | 2856 | 1428.0 | 126.9 | 63.5 | The role of inflammation in depression: from evolutionary imperative to modern treatment target. | Andrew H Miller, Charles L Raison | Nat Rev Immunol | 2016 | 26711676 | No |
| 2669 | 2855 | 1427.5 | 95.4 | 47.7 | Performing the exact test of Hardy-Weinberg proportion for multiple alleles. | S W Guo, E A Thompson | Biometrics | 1992 | 1637966 | Yes |
| 2670 | 5709 | 1427.2 | 257.2 | 64.3 | Genome sequence-based species delimitation with confidence intervals and improved distance functions. | Jan P Meier-Kolthoff, Alexander F Auch, Hans-Peter Klenk, Markus Goker | BMC Bioinformatics | 2013 | 23432962 | Yes |
| 2671 | 2853 | 1426.5 | 78.5 | 39.2 | Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. | D H Figurski, D R Helinski | Proc Natl Acad Sci U S A | 1979 | 377280 | Yes |
| 2672 | 2853 | 1426.5 | 85.1 | 42.5 | Accurate and robust brain image alignment using boundary-based registration. | Douglas N Greve, Bruce Fischl | Neuroimage | 2009 | 19573611 | Yes |
| 2673 | 1426 | 1426.0 | 40.8 | 40.8 | A Wilcoxon-type test for trend. | J Cuzick | Stat Med | 1985 | 3992076 | Yes |
| 2674 | 1426 | 1426.0 | 30.7 | 30.7 | Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. | R I Morimoto | Genes Dev | 1998 | 9869631 | No |
| 2675 | 1426 | 1426.0 | 43.8 | 43.8 | The stress response to trauma and surgery. | J P Desborough | Br J Anaesth | 2000 | 10927999 | No |
| 2676 | 1426 | 1426.0 | 40.7 | 40.7 | The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. | T Szkudelski | Physiol Res | 2001 | 11829314 | No |
| 2677 | 1426 | 1426.0 | 31.4 | 31.4 | Cancer of the ovary. | Stephen A Cannistra | N Engl J Med | 2004 | 15590954 | No |
| 2678 | 1426 | 1426.0 | 71.7 | 71.7 | Systematic text condensation: a strategy for qualitative analysis. | Kirsti Malterud | Scand J Public Health | 2012 | 23221918 | Yes |
| 2679 | 2851 | 1425.5 | 66.8 | 33.4 | Microenvironmental regulation of metastasis. | Johanna A Joyce, Jeffrey W Pollard | Nat Rev Cancer | 2009 | 19279573 | No |
| 2680 | 9977 | 1425.3 | 296.7 | 42.4 | pROC: an open-source package for R and S+ to analyze and compare ROC curves. | Xavier Robin, Natacha Turck, Alexandre Hainard, Natalia Tiberti, Frederique Lisacek, Jean-Charles Sanchez, Markus Muller | BMC Bioinformatics | 2011 | 21414208 | Yes |
| 2681 | 1425 | 1425.0 | 58.9 | 58.9 | Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. | R W Bohannon | Age Ageing | 1997 | 9143432 | Yes |
| 2682 | 1425 | 1425.0 | 0.0 | 0.0 | The relation of the trail making test to organic brain damage. | R M Reitan | J Consult Psychol | 1955 | 13263471 | Yes |
| 2683 | 1425 | 1425.0 | 49.3 | 49.3 | Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. | Tamas Roszer | Mediators Inflamm | 2015 | 26089604 | No |
| 2684 | 2849 | 1424.5 | 65.5 | 32.8 | Disruption of epithelial cell-matrix interactions induces apoptosis. | S M Frisch, H Francis | J Cell Biol | 1994 | 8106557 | Yes |
| 2685 | 2848 | 1424.0 | 107.8 | 53.9 | Glutathione peroxidase activity in selenium-deficient rat liver. | R A Lawrence, R F Burk | Biochem Biophys Res Commun | 1976 | 971321 | Yes |
| 2686 | 1424 | 1424.0 | 44.2 | 44.2 | The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. | L W Swanson | Brain Res Bull | 1982 | 6816390 | Yes |
| 2687 | 1423 | 1423.0 | 34.4 | 34.4 | Optical microcavities. | Kerry J Vahala | Nature | 2003 | 12917698 | Yes |
| 2688 | 2846 | 1423.0 | 110.8 | 55.4 | Functional Classification and Experimental Dissection of Long Noncoding RNAs. | Florian Kopp, Joshua T Mendell | Cell | 2018 | 29373828 | No |
| 2689 | 4268 | 1422.7 | 110.4 | 36.8 | Prediction of total genetic value using genome-wide dense marker maps. | T H Meuwissen, B J Hayes, M E Goddard | Genetics | 2001 | 11290733 | Yes |
| 2690 | 1422 | 1422.0 | 23.5 | 23.5 | A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. | A M Olovnikov | J Theor Biol | 1973 | 4754905 | Yes |
| 2691 | 1422 | 1422.0 | 32.4 | 32.4 | Long-term potentiation and memory. | M A Lynch | Physiol Rev | 2004 | 14715912 | No |
| 2692 | 1422 | 1422.0 | 0.0 | 0.0 | Comparing individual means in the analysis of variance. | J W Tukey | Biometrics | 1949 | 18151955 | Yes |
| 2693 | 1421 | 1421.0 | 33.9 | 33.9 | Surrogate endpoints in clinical trials: definition and operational criteria. | R L Prentice | Stat Med | 1989 | 2727467 | Yes |
| 2694 | 1421 | 1421.0 | 27.5 | 27.5 | Selection of successive tumour lines for metastasis. | I J Fidler | Nat New Biol | 1973 | 4512654 | Yes |
| 2695 | 1421 | 1421.0 | 34.6 | 34.6 | The basic science of gene therapy. | R C Mulligan | Science | 1993 | 8493530 | No |
| 2696 | 1421 | 1421.0 | 48.7 | 48.7 | The pathobiology of vascular dementia. | Costantino Iadecola | Neuron | 2013 | 24267647 | No |
| 2697 | 1419 | 1419.0 | 0.0 | 0.0 | Metabolic stability and epigenesis in randomly constructed genetic nets. | S A Kauffman | J Theor Biol | 1969 | 5803332 | Yes |
| 2698 | 1419 | 1419.0 | 39.3 | 39.3 | Time is brain--quantified. | Jeffrey L Saver | Stroke | 2006 | 16339467 | Yes |
| 2699 | 1419 | 1419.0 | 39.6 | 39.6 | Atomic layer deposition: an overview. | Steven M George | Chem Rev | 2010 | 19947596 | Yes |
| 2700 | 1418 | 1418.0 | 53.7 | 53.7 | Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases. | K Tamura | Mol Biol Evol | 1992 | 1630306 | Yes |
| 2701 | 2836 | 1418.0 | 85.8 | 42.9 | Glycine potentiates the NMDA response in cultured mouse brain neurons. | J W Johnson, P Ascher | Nature | 1987 | 2433595 | Yes |
| 2702 | 1418 | 1418.0 | 23.1 | 23.1 | Cancer. Addiction to oncogenes--the Achilles heal of cancer. | I Bernard Weinstein | Science | 2002 | 12098689 | No |
| 2703 | 1418 | 1418.0 | 36.3 | 36.3 | Electrochemiluminescence (ECL). | Mark M Richter | Chem Rev | 2004 | 15186186 | No |
| 2704 | 1418 | 1418.0 | 35.5 | 35.5 | Hydrogen sulphide and its therapeutic potential. | Csaba Szabo | Nat Rev Drug Discov | 2007 | 17948022 | No |
| 2705 | 1418 | 1418.0 | 39.6 | 39.6 | Infection in solid-organ transplant recipients. | Jay A Fishman | N Engl J Med | 2007 | 18094380 | No |
| 2706 | 2834 | 1417.0 | 61.7 | 30.9 | Prediction of protein conformation. | P Y Chou, G D Fasman | Biochemistry | 1974 | 4358940 | Yes |
| 2707 | 7081 | 1416.2 | 204.6 | 40.9 | Transection of the oesophagus for bleeding oesophageal varices. | R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams | Br J Surg | 1973 | 4541913 | Yes |
| 2708 | 2832 | 1416.0 | 92.2 | 46.1 | Central sensitization: a generator of pain hypersensitivity by central neural plasticity. | Alban Latremoliere, Clifford J Woolf | J Pain | 2009 | 19712899 | No |
| 2709 | 2830 | 1415.0 | 74.2 | 37.1 | Biology of incretins: GLP-1 and GIP. | Laurie L Baggio, Daniel J Drucker | Gastroenterology | 2007 | 17498508 | No |
| 2710 | 2830 | 1415.0 | 85.5 | 42.8 | Crosstalk of reactive oxygen species and NF-κB signaling. | Michael J Morgan, Zheng-Gang Liu | Cell Res | 2011 | 21187859 | No |
| 2711 | 4244 | 1414.7 | 91.4 | 30.5 | Toll-like receptors. | Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira | Annu Rev Immunol | 2003 | 12524386 | No |
| 2712 | 1414 | 1414.0 | 50.3 | 50.3 | Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. | M P Blaustein | Am J Physiol | 1977 | 324293 | No |
| 2713 | 1414 | 1414.0 | 33.3 | 33.3 | Protein kinase C: structure, function, and regulation. | A C Newton | J Biol Chem | 1995 | 7499357 | No |
| 2714 | 5656 | 1414.0 | 190.3 | 47.6 | Validation of a combined comorbidity index. | M Charlson, T P Szatrowski, J Peterson, J Gold | J Clin Epidemiol | 1994 | 7722560 | Yes |
| 2715 | 2828 | 1414.0 | 99.9 | 50.0 | Inflammasomes: mechanism of assembly, regulation and signalling. | Petr Broz, Vishva M Dixit | Nat Rev Immunol | 2016 | 27291964 | No |
| 2716 | 2827 | 1413.5 | 72.7 | 36.4 | CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. | D G Higgins, P M Sharp | Gene | 1988 | 3243435 | Yes |
| 2717 | 1413 | 1413.0 | 41.7 | 41.7 | How brains beware: neural mechanisms of emotional attention. | Patrik Vuilleumier | Trends Cogn Sci | 2005 | 16289871 | Yes |
| 2718 | 1413 | 1413.0 | 34.8 | 34.8 | Immortal time bias in pharmaco-epidemiology. | Samy Suissa | Am J Epidemiol | 2008 | 18056625 | No |
| 2719 | 1413 | 1413.0 | 65.3 | 65.3 | The new statistics: why and how. | Geoff Cumming | Psychol Sci | 2014 | 24220629 | Yes |
| 2720 | 8478 | 1413.0 | 313.1 | 52.2 | ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB. | James A Maier, Carmenza Martinez, Koushik Kasavajhala, Lauren Wickstrom, Kevin E Hauser, Carlos Simmerling | J Chem Theory Comput | 2015 | 26574453 | Yes |
| 2721 | 2823 | 1411.5 | 62.9 | 31.4 | Empirical predictions of protein conformation. | P Y Chou, G D Fasman | Annu Rev Biochem | 1978 | 354496 | No |
| 2722 | 1411 | 1411.0 | 44.7 | 44.7 | Glutathione metabolism and its selective modification. | A Meister | J Biol Chem | 1988 | 3053703 | No |
| 2723 | 1411 | 1411.0 | 50.4 | 50.4 | Mediators and mechanisms of change in psychotherapy research. | Alan E Kazdin | Annu Rev Clin Psychol | 2007 | 17716046 | No |
| 2724 | 2822 | 1411.0 | 81.6 | 40.8 | Type 2 diabetes as an inflammatory disease. | Marc Y Donath, Steven E Shoelson | Nat Rev Immunol | 2011 | 21233852 | No |
| 2725 | 2820 | 1410.0 | 179.6 | 89.8 | A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. | E S Grood, W J Suntay | J Biomech Eng | 1983 | 6865355 | Yes |
| 2726 | 1410 | 1410.0 | 40.4 | 40.4 | Psychological and neural mechanisms of the affective dimension of pain. | D D Price | Science | 2000 | 10846154 | No |
| 2727 | 1410 | 1410.0 | 51.1 | 51.1 | Visual attention: the past 25 years. | Marisa Carrasco | Vision Res | 2011 | 21549742 | No |
| 2728 | 2820 | 1410.0 | 95.9 | 48.0 | Severe sepsis and septic shock. | Derek C Angus, Tom Van Der Poll | N Engl J Med | 2013 | 23984731 | No |
| 2729 | 2820 | 1410.0 | 125.5 | 62.8 | Activation of apoptosis signalling pathways by reactive oxygen species. | Maureen Redza-Dutordoir, Diana A Averill-Bates | Biochim Biophys Acta | 2016 | 27646922 | No |
| 2730 | 1409 | 1409.0 | 34.5 | 34.5 | Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. | G L Semenza | Oncogene | 2010 | 19946328 | No |
| 2731 | 5635 | 1408.8 | 130.1 | 32.5 | Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. | Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun | N Engl J Med | 2003 | 12711737 | Yes |
| 2732 | 11268 | 1408.5 | 503.8 | 63.0 | Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. | Yingyao Zhou, Bin Zhou, Lars Pache, Max Chang, Alireza Hadj Khodabakhshi, Olga Tanaseichuk, Christopher Benner, Sumit K Chanda | Nat Commun | 2019 | 30944313 | Yes |
| 2733 | 1408 | 1408.0 | 34.0 | 34.0 | Speculations on the functions of the major heat shock and glucose-regulated proteins. | H R Pelham | Cell | 1986 | 2944601 | Yes |
| 2734 | 1408 | 1408.0 | 44.4 | 44.4 | Circuitry and functional aspects of the insular lobe in primates including humans. | J R Augustine | Brain Res Brain Res Rev | 1996 | 8957561 | No |
| 2735 | 1408 | 1408.0 | 28.4 | 28.4 | microRNAs: tiny regulators with great potential. | V Ambros | Cell | 2001 | 11779458 | No |
| 2736 | 1408 | 1408.0 | 34.9 | 34.9 | Pathways of oxidative damage. | James A Imlay | Annu Rev Microbiol | 2003 | 14527285 | No |
| 2737 | 1408 | 1408.0 | 33.2 | 33.2 | Evaluating medication effects outside of clinical trials: new-user designs. | Wayne A Ray | Am J Epidemiol | 2003 | 14585769 | Yes |
| 2738 | 1408 | 1408.0 | 33.8 | 33.8 | Correlates of protection induced by vaccination. | Stanley A Plotkin | Clin Vaccine Immunol | 2010 | 20463105 | No |
| 2739 | 2816 | 1408.0 | 75.4 | 37.7 | miRBase: integrating microRNA annotation and deep-sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2011 | 21037258 | Yes |
| 2740 | 1407 | 1407.0 | 30.8 | 30.8 | Codon usage and tRNA content in unicellular and multicellular organisms. | T Ikemura | Mol Biol Evol | 1985 | 3916708 | No |
| 2741 | 14064 | 1406.4 | 525.5 | 52.5 | The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. | Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gotzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David Moher | BMJ | 2009 | 19622552 | No |
| 2742 | 1406 | 1406.0 | 29.6 | 29.6 | Recognition and processing of ubiquitin-protein conjugates by the proteasome. | Daniel Finley | Annu Rev Biochem | 2009 | 19489727 | No |
| 2743 | 2812 | 1406.0 | 62.1 | 31.1 | NMR View: A computer program for the visualization and analysis of NMR data. | B A Johnson, R A Blevins | J Biomol NMR | 1994 | 22911360 | Yes |
| 2744 | 2811 | 1405.5 | 72.0 | 36.0 | A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. | R L Juliano, V Ling | Biochim Biophys Acta | 1976 | 990323 | Yes |
| 2745 | 1405 | 1405.0 | 37.9 | 37.9 | Overview of general physiologic features and functions of vitamin D. | Hector F DeLuca | Am J Clin Nutr | 2004 | 15585789 | No |
| 2746 | 1405 | 1405.0 | 48.0 | 48.0 | The biogenesis and emerging roles of circular RNAs. | Ling-Ling Chen | Nat Rev Mol Cell Biol | 2016 | 26908011 | Yes |
| 2747 | 2809 | 1404.5 | 84.1 | 42.0 | The cognitive control of emotion. | Kevin N Ochsner, James J Gross | Trends Cogn Sci | 2005 | 15866151 | No |
| 2748 | 8424 | 1404.0 | 228.5 | 38.1 | Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. | Ana Conesa, Stefan Gotz, Juan Miguel Garcia-Gomez, Javier Terol, Manuel Talon, Montserrat Robles | Bioinformatics | 2005 | 16081474 | Yes |
| 2749 | 1404 | 1404.0 | 44.4 | 44.4 | Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? | Thomas Grobner | Nephrol Dial Transplant | 2006 | 16431890 | Yes |
| 2750 | 4212 | 1404.0 | 98.1 | 32.7 | Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? | Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg | Nat Rev Genet | 2008 | 18197166 | No |
| 2751 | 5613 | 1403.2 | 182.4 | 45.6 | Epidemiology and causes of preterm birth. | Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto Romero | Lancet | 2008 | 18177778 | No |
| 2752 | 1403 | 1403.0 | 42.7 | 42.7 | Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. | E B Hunziker | Osteoarthritis Cartilage | 2002 | 12056848 | No |
| 2753 | 7015 | 1403.0 | 337.9 | 67.6 | Using the framework method for the analysis of qualitative data in multi-disciplinary health research. | Nicola K Gale, Gemma Heath, Elaine Cameron, Sabina Rashid, Sabi Redwood | BMC Med Res Methodol | 2013 | 24047204 | Yes |
| 2754 | 2805 | 1402.5 | 82.6 | 41.3 | Epidemiology and outcomes of osteoporotic fractures. | Steven R Cummings, L Joseph Melton | Lancet | 2002 | 12049882 | No |
| 2755 | 2805 | 1402.5 | 68.2 | 34.1 | Reducing the dimensionality of data with neural networks. | G E Hinton, R R Salakhutdinov | Science | 2006 | 16873662 | Yes |
| 2756 | 1402 | 1402.0 | 27.0 | 27.0 | Epithelial-mesenchymal transitions in development and pathologies. | Jean Paul Thiery | Curr Opin Cell Biol | 2003 | 14644200 | No |
| 2757 | 5604 | 1401.0 | 238.6 | 59.6 | Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. | L A Papile, J Burstein, R Burstein, H Koffler | J Pediatr | 1978 | 305471 | Yes |
| 2758 | 1401 | 1401.0 | 52.5 | 52.5 | The case for motivated reasoning. | Z Kunda | Psychol Bull | 1990 | 2270237 | No |
| 2759 | 1401 | 1401.0 | 31.4 | 31.4 | Prediction of protein cellular attributes using pseudo-amino acid composition. | K C Chou | Proteins | 2001 | 11288174 | Yes |
| 2760 | 15411 | 1401.0 | 486.3 | 44.2 | International physical activity questionnaire: 12-country reliability and validity. | Cora L Craig, Alison L Marshall, Michael Sjostrom, Adrian E Bauman, Michael L Booth, Barbara E Ainsworth, Michael Pratt, Ulf Ekelund, Agneta Yngve, James F Sallis, Pekka Oja | Med Sci Sports Exerc | 2003 | 12900694 | Yes |
| 2761 | 1401 | 1401.0 | 58.6 | 58.6 | The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. | Erik G Willcutt | Neurotherapeutics | 2012 | 22976615 | Yes |
| 2762 | 2802 | 1401.0 | 103.0 | 51.5 | Communication by Extracellular Vesicles: Where We Are and Where We Need to Go. | Mercedes Tkach, Clotilde Thery | Cell | 2016 | 26967288 | No |
| 2763 | 2801 | 1400.5 | 58.9 | 29.4 | Regulated portals of entry into the cell. | Sean D Conner, Sandra L Schmid | Nature | 2003 | 12621426 | No |
| 2764 | 4200 | 1400.0 | 137.6 | 45.9 | MR diffusion tensor spectroscopy and imaging. | P J Basser, J Mattiello, D LeBihan | Biophys J | 1994 | 8130344 | Yes |
| 2765 | 1400 | 1400.0 | 45.6 | 45.6 | Cognitive and affective development in adolescence. | Laurence Steinberg | Trends Cogn Sci | 2005 | 15668099 | No |
| 2766 | 4200 | 1400.0 | 124.0 | 41.3 | HMMER web server: interactive sequence similarity searching. | Robert D Finn, Jody Clements, Sean R Eddy | Nucleic Acids Res | 2011 | 21593126 | Yes |
| 2767 | 2799 | 1399.5 | 0.0 | 0.0 | Immunoassay of endogenous plasma insulin in man. | R S Yalow, S A Berson | J Clin Invest | 1960 | 13846364 | Yes |
| 2768 | 2799 | 1399.5 | 74.7 | 37.4 | Epidemiology of Parkinson's disease. | Lonneke M L De Lau, Monique M B Breteler | Lancet Neurol | 2006 | 16713924 | No |
| 2769 | 8397 | 1399.5 | 254.6 | 42.4 | Free radicals and antioxidants in normal physiological functions and human disease. | Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser | Int J Biochem Cell Biol | 2007 | 16978905 | No |
| 2770 | 1399 | 1399.0 | 25.5 | 25.5 | Chromatin modification and epigenetic reprogramming in mammalian development. | En Li | Nat Rev Genet | 2002 | 12209141 | No |
| 2771 | 2798 | 1399.0 | 63.9 | 31.9 | Raster3D Version 2.0. A program for photorealistic molecular graphics. | E A Merritt, M E Murphy | Acta Crystallogr D Biol Crystallogr | 1994 | 15299354 | Yes |
| 2772 | 4195 | 1398.3 | 155.2 | 51.7 | A new method for off-line removal of ocular artifact. | G Gratton, M G Coles, E Donchin | Electroencephalogr Clin Neurophysiol | 1983 | 6187540 | Yes |
| 2773 | 1398 | 1398.0 | 31.5 | 31.5 | Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. | M Kozak | Microbiol Rev | 1983 | 6343825 | No |
| 2774 | 1398 | 1398.0 | 25.0 | 25.0 | SUMO: a history of modification. | Ronald T Hay | Mol Cell | 2005 | 15808504 | No |
| 2775 | 2795 | 1397.5 | 94.5 | 47.2 | Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. | Hirenkumar K Makadia, Steven J Siegel | Polymers (Basel) | 2011 | 22577513 | Yes |
| 2776 | 2794 | 1397.0 | 103.2 | 51.6 | Biology of disease: free radicals and tissue injury. | B A Freeman, J D Crapo | Lab Invest | 1982 | 6290784 | No |
| 2777 | 2793 | 1396.5 | 0.0 | 0.0 | Microdetermination of long-chain fatty acids in plasma and tissues. | V P Dole, H Meinertz | J Biol Chem | 1960 | 13817286 | Yes |
| 2778 | 1395 | 1395.0 | 46.5 | 46.5 | Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. | T Spector | Anal Biochem | 1978 | 655375 | Yes |
| 2779 | 1395 | 1395.0 | 46.8 | 46.8 | Osteoblast adhesion on biomaterials. | K Anselme | Biomaterials | 2000 | 10711964 | No |
| 2780 | 1395 | 1395.0 | 0.0 | 0.0 | On the psychophysical law. | S S Stevens | Psychol Rev | 1957 | 13441853 | Yes |
| 2781 | 1395 | 1395.0 | 146.4 | 146.4 | Sample size determination and power analysis using the G*Power software. | Hyun Kang | J Educ Eval Health Prof | 2021 | 34325496 | No |
| 2782 | 2788 | 1394.0 | 123.1 | 61.5 | Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. | Luigi Ferrucci, Elisa Fabbri | Nat Rev Cardiol | 2018 | 30065258 | No |
| 2783 | 4180 | 1393.3 | 102.5 | 34.2 | METAL: fast and efficient meta-analysis of genomewide association scans. | Cristen J Willer, Yun Li, Goncalo R Abecasis | Bioinformatics | 2010 | 20616382 | Yes |
| 2784 | 1393 | 1393.0 | 30.3 | 30.3 | Mechanisms of foxp3+ T regulatory cell-mediated suppression. | Ethan M Shevach | Immunity | 2009 | 19464986 | No |
| 2785 | 6963 | 1392.6 | 274.2 | 54.8 | Frailty in elderly people. | Andrew Clegg, John Young, Steve Iliffe, Marcel Olde Rikkert, Kenneth Rockwood | Lancet | 2013 | 23395245 | No |
| 2786 | 1392 | 1392.0 | 46.0 | 46.0 | Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. | A A Grace | Neuroscience | 1991 | 1676137 | No |
| 2787 | 1392 | 1392.0 | 23.8 | 23.8 | Protein modification by SUMO. | Erica S Johnson | Annu Rev Biochem | 2004 | 15189146 | No |
| 2788 | 2784 | 1392.0 | 81.9 | 41.0 | Inflammatory mechanisms in obesity. | Margaret F Gregor, Gokhan S Hotamisligil | Annu Rev Immunol | 2011 | 21219177 | No |
| 2789 | 1392 | 1392.0 | 83.7 | 83.7 | COVID-19 and African Americans. | Clyde W Yancy | JAMA | 2020 | 32293639 | Yes |
| 2790 | 1391 | 1391.0 | 31.4 | 31.4 | Liver fibrosis -- from bench to bedside. | Scott L Friedman | J Hepatol | 2003 | 12591185 | No |
| 2791 | 1391 | 1391.0 | 0.0 | 0.0 | The anterior approach for removal of ruptured cervical disks. | R B Cloward | J Neurosurg | 1958 | 13599052 | Yes |
| 2792 | 5563 | 1390.8 | 113.7 | 28.4 | Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. | D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini | Science | 2005 | 15718470 | Yes |
| 2793 | 12510 | 1390.0 | 320.1 | 35.6 | MolProbity: all-atom structure validation for macromolecular crystallography. | Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C Richardson | Acta Crystallogr D Biol Crystallogr | 2010 | 20057044 | Yes |
| 2794 | 5557 | 1389.2 | 301.1 | 75.3 | Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks. | Shaoqing Ren, Kaiming He, Ross Girshick, Jian Sun | IEEE Trans Pattern Anal Mach Intell | 2017 | 27295650 | Yes |
| 2795 | 1389 | 1389.0 | 41.0 | 41.0 | Akaike's information criterion in generalized estimating equations. | W Pan | Biometrics | 2001 | 11252586 | Yes |
| 2796 | 5556 | 1389.0 | 176.3 | 44.1 | Biological identifications through DNA barcodes. | Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R DeWaard | Proc Biol Sci | 2003 | 12614582 | Yes |
| 2797 | 1389 | 1389.0 | 0.0 | 0.0 | Immunological function of the thymus. | J F Miller | Lancet | 1961 | 14474038 | Yes |
| 2798 | 1389 | 1389.0 | 39.9 | 39.9 | Polycystic ovary syndrome. | David A Ehrmann | N Engl J Med | 2005 | 15788499 | No |
| 2799 | 2777 | 1388.5 | 57.5 | 28.8 | Community structure in social and biological networks. | M Girvan, M E J Newman | Proc Natl Acad Sci U S A | 2002 | 12060727 | No |
| 2800 | 1388 | 1388.0 | 0.0 | 0.0 | Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. | J R David | Proc Natl Acad Sci U S A | 1966 | 5229858 | Yes |
| 2801 | 2775 | 1387.5 | 84.9 | 42.5 | Mortality by cause for eight regions of the world: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9142060 | Yes |
| 2802 | 2775 | 1387.5 | 79.3 | 39.6 | Mitochondria: in sickness and in health. | Jodi Nunnari, Anu Suomalainen | Cell | 2012 | 22424226 | No |
| 2803 | 1387 | 1387.0 | 42.2 | 42.2 | Internal models for motor control and trajectory planning. | M Kawato | Curr Opin Neurobiol | 1999 | 10607637 | No |
| 2804 | 2774 | 1387.0 | 148.5 | 74.2 | Making Neighborhood-Disadvantage Metrics Accessible - The Neighborhood Atlas. | Amy J H Kind, William R Buckingham | N Engl J Med | 2018 | 29949490 | Yes |
| 2805 | 2773 | 1386.5 | 40.3 | 20.1 | Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. | J E Sulston, H R Horvitz | Dev Biol | 1977 | 838129 | Yes |
| 2806 | 2772 | 1386.0 | 60.2 | 30.1 | Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. | J M Kyriakis, J Avruch | Physiol Rev | 2001 | 11274345 | No |
| 2807 | 1386 | 1386.0 | 45.9 | 45.9 | Stochastic thermodynamics, fluctuation theorems and molecular machines. | Udo Seifert | Rep Prog Phys | 2012 | 23168354 | No |
| 2808 | 2771 | 1385.5 | 71.7 | 35.9 | A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. | J Messing, J Vieira | Gene | 1982 | 6295880 | Yes |
| 2809 | 2771 | 1385.5 | 67.0 | 33.5 | Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. | P Van Den Driessche, James Watmough | Math Biosci | 2002 | 12387915 | Yes |
| 2810 | 8310 | 1385.0 | 280.2 | 46.7 | The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis. | A Miyake, N P Friedman, M J Emerson, A H Witzki, A Howerter, T D Wager | Cogn Psychol | 2000 | 10945922 | Yes |
| 2811 | 1385 | 1385.0 | 32.7 | 32.7 | The path to ubiquitous and low-cost organic electronic appliances on plastic. | Stephen R Forrest | Nature | 2004 | 15118718 | Yes |
| 2812 | 2769 | 1384.5 | 98.6 | 49.3 | A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. | C M Tsai, C E Frasch | Anal Biochem | 1982 | 6176137 | Yes |
| 2813 | 2769 | 1384.5 | 398.3 | 199.2 | Sample sizes for saturation in qualitative research: A systematic review of empirical tests. | Monique Hennink, Bonnie N Kaiser | Soc Sci Med | 2022 | 34785096 | Yes |
| 2814 | 1384 | 1384.0 | 25.8 | 25.8 | Mobile elements: drivers of genome evolution. | Haig H Kazazian | Science | 2004 | 15016989 | No |
| 2815 | 1383 | 1383.0 | 53.0 | 53.0 | Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. | M A Lemp | CLAO J | 1995 | 8565190 | No |
| 2816 | 2765 | 1382.5 | 87.3 | 43.6 | The reward circuit: linking primate anatomy and human imaging. | Suzanne N Haber, Brian Knutson | Neuropsychopharmacology | 2010 | 19812543 | No |
| 2817 | 1382 | 1382.0 | 52.4 | 52.4 | Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. | Thomas Heberer | Toxicol Lett | 2002 | 11988354 | Yes |
| 2818 | 1382 | 1382.0 | 0.0 | 0.0 | Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. | W C Schneider | J Biol Chem | 1948 | 18886166 | Yes |
| 2819 | 2762 | 1381.0 | 62.2 | 31.1 | An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. | A A Beg, D Baltimore | Science | 1996 | 8864118 | Yes |
| 2820 | 1381 | 1381.0 | 24.3 | 24.3 | The molecular motor toolbox for intracellular transport. | Ronald D Vale | Cell | 2003 | 12600311 | No |
| 2821 | 1381 | 1381.0 | 38.7 | 38.7 | Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. | Arnold I Caplan | J Cell Physiol | 2007 | 17620285 | No |
| 2822 | 1381 | 1381.0 | 33.1 | 33.1 | Targeting DNA topoisomerase II in cancer chemotherapy. | John L Nitiss | Nat Rev Cancer | 2009 | 19377506 | No |
| 2823 | 2760 | 1380.0 | 0.0 | 0.0 | A method of trace iodination of proteins for immunologic studies. | P J McConahey, F J Dixon | Int Arch Allergy Appl Immunol | 1966 | 4160044 | Yes |
| 2824 | 2760 | 1380.0 | 72.3 | 36.1 | Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. | D Marion, K Wuthrich | Biochem Biophys Res Commun | 1983 | 6307308 | Yes |
| 2825 | 1380 | 1380.0 | 71.2 | 71.2 | Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. | Anna Maria Carlsson | Pain | 1983 | 6602967 | Yes |
| 2826 | 1380 | 1380.0 | 36.4 | 36.4 | Functionalized acenes and heteroacenes for organic electronics. | John E Anthony | Chem Rev | 2006 | 17165682 | Yes |
| 2827 | 1380 | 1380.0 | 39.2 | 39.2 | The locus coeruleus and noradrenergic modulation of cognition. | Susan J Sara | Nat Rev Neurosci | 2009 | 19190638 | No |
| 2828 | 1380 | 1380.0 | 43.6 | 43.6 | The inflammatory response in myocardial injury, repair, and remodelling. | Nikolaos G Frangogiannis | Nat Rev Cardiol | 2014 | 24663091 | No |
| 2829 | 4139 | 1379.7 | 181.6 | 60.5 | Measurement of health status. Ascertaining the minimal clinically important difference. | R Jaeschke, J Singer, G H Guyatt | Control Clin Trials | 1989 | 2691207 | Yes |
| 2830 | 2759 | 1379.5 | 73.1 | 36.5 | Hydrogels for tissue engineering. | K Y Lee, D J Mooney | Chem Rev | 2001 | 11710233 | No |
| 2831 | 1379 | 1379.0 | 40.2 | 40.2 | Letter: Grading of angina pectoris. | L Campeau | Circulation | 1976 | 947585 | Yes |
| 2832 | 1379 | 1379.0 | 34.2 | 34.2 | Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. | G Von Heijne | J Mol Biol | 1992 | 1593632 | Yes |
| 2833 | 1379 | 1379.0 | 49.1 | 49.1 | Functional organization of central pathways regulating the cardiovascular system. | R A Dampney | Physiol Rev | 1994 | 8171117 | No |
| 2834 | 5516 | 1379.0 | 137.5 | 34.4 | The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. | Konstantin Arnold, Lorenza Bordoli, Jurgen Kopp, Torsten Schwede | Bioinformatics | 2006 | 16301204 | Yes |
| 2835 | 1379 | 1379.0 | 63.3 | 63.3 | Review of the psychometric evidence of the perceived stress scale. | Eun-Hyun Lee | Asian Nurs Res (Korean Soc Nurs Sci) | 2012 | 25031113 | Yes |
| 2836 | 1378 | 1378.0 | 0.0 | 0.0 | Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. | W D Hamilton | Science | 1967 | 6021675 | Yes |
| 2837 | 1378 | 1378.0 | 47.7 | 47.7 | History of the Rochester Epidemiology Project. | L J Melton | Mayo Clin Proc | 1996 | 8594285 | No |
| 2838 | 1378 | 1378.0 | 42.0 | 42.0 | The emotional dog and its rational tail: a social intuitionist approach to moral judgment. | J Haidt | Psychol Rev | 2001 | 11699120 | Yes |
| 2839 | 4133 | 1377.7 | 140.0 | 46.7 | Rehospitalizations among patients in the Medicare fee-for-service program. | Stephen F Jencks, Mark V Williams, Eric A Coleman | N Engl J Med | 2009 | 19339721 | Yes |
| 2840 | 1377 | 1377.0 | 39.5 | 39.5 | Qinghaosu (artemisinin): an antimalarial drug from China. | D L Klayman | Science | 1985 | 3887571 | No |
| 2841 | 5507 | 1376.8 | 130.3 | 32.6 | Autophagy fights disease through cellular self-digestion. | Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky | Nature | 2008 | 18305538 | No |
| 2842 | 11014 | 1376.8 | 282.6 | 35.3 | A method and server for predicting damaging missense mutations. | Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev | Nat Methods | 2010 | 20354512 | Yes |
| 2843 | 2752 | 1376.0 | 100.6 | 50.3 | Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. | J M Tanner, R H Whitehouse | Arch Dis Child | 1976 | 952550 | Yes |
| 2844 | 4128 | 1376.0 | 104.0 | 34.7 | Astrocyte-endothelial interactions at the blood-brain barrier. | N Joan Abbott, Lars Ronnback, Elisabeth Hansson | Nat Rev Neurosci | 2006 | 16371949 | No |
| 2845 | 1376 | 1376.0 | 45.4 | 45.4 | Drug transport across the blood-brain barrier. | William M Pardridge | J Cereb Blood Flow Metab | 2012 | 22929442 | No |
| 2846 | 2751 | 1375.5 | 144.9 | 72.5 | A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. | M Roland, R Morris | Spine (Phila Pa 1976) | 1983 | 6222486 | Yes |
| 2847 | 2751 | 1375.5 | 78.2 | 39.1 | A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. | Yan Zhao, Donald G Truhlar | J Chem Phys | 2006 | 17129083 | Yes |
| 2848 | 8252 | 1375.3 | 344.6 | 57.4 | Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. | Zobair M Younossi, Aaron B Koenig, Dinan Abdelatif, Yousef Fazel, Linda Henry, Mark Wymer | Hepatology | 2016 | 26707365 | No |
| 2849 | 1375 | 1375.0 | 42.5 | 42.5 | Tumor delivery of macromolecular drugs based on the EPR effect. | Vladimir Torchilin | Adv Drug Deliv Rev | 2011 | 20304019 | No |
| 2850 | 5499 | 1374.8 | 129.0 | 32.2 | A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. | Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless | Angew Chem Int Ed Engl | 2002 | 12203546 | Yes |
| 2851 | 1374 | 1374.0 | 29.8 | 29.8 | Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. | S S Ferguson | Pharmacol Rev | 2001 | 11171937 | No |
| 2852 | 1374 | 1374.0 | 29.2 | 29.2 | The many faces of macrophage activation. | David M Mosser | J Leukoc Biol | 2003 | 12554797 | No |
| 2853 | 2747 | 1373.5 | 66.4 | 33.2 | Principles of bioactive lipid signalling: lessons from sphingolipids. | Yusuf A Hannun, Lina M Obeid | Nat Rev Mol Cell Biol | 2008 | 18216770 | No |
| 2854 | 2747 | 1373.5 | 60.8 | 30.4 | Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. | Jane E Visvader, Geoffrey J Lindeman | Nat Rev Cancer | 2008 | 18784658 | No |
| 2855 | 2747 | 1373.5 | 81.5 | 40.8 | Ischemia and reperfusion--from mechanism to translation. | Holger K Eltzschig, Tobias Eckle | Nat Med | 2011 | 22064429 | No |
| 2856 | 2746 | 1373.0 | 53.9 | 26.9 | Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. | A J Berk, P A Sharp | Cell | 1977 | 922889 | Yes |
| 2857 | 2746 | 1373.0 | 0.0 | 0.0 | A protein sequenator. | P Edman, G Begg | Eur J Biochem | 1967 | 6059350 | Yes |
| 2858 | 1373 | 1373.0 | 36.5 | 36.5 | A molecular view of microbial diversity and the biosphere. | N R Pace | Science | 1997 | 9115194 | No |
| 2859 | 2746 | 1373.0 | 0.0 | 0.0 | The respiratory chain and oxidative phosphorylation. | B Chance, G R Williams | Adv Enzymol Relat Subj Biochem | 1956 | 13313307 | Yes |
| 2860 | 2746 | 1373.0 | 57.9 | 28.9 | TM-align: a protein structure alignment algorithm based on the TM-score. | Yang Zhang, Jeffrey Skolnick | Nucleic Acids Res | 2005 | 15849316 | Yes |
| 2861 | 5492 | 1373.0 | 147.4 | 36.9 | Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. | Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan | Stat Med | 2008 | 17569110 | Yes |
| 2862 | 4119 | 1373.0 | 97.9 | 32.6 | Evolution and functions of long noncoding RNAs. | Chris P Ponting, Peter L Oliver, Wolf Reik | Cell | 2009 | 19239885 | No |
| 2863 | 1373 | 1373.0 | 42.9 | 42.9 | Determining association constants from titration experiments in supramolecular chemistry. | Pall Thordarson | Chem Soc Rev | 2011 | 21125111 | Yes |
| 2864 | 4118 | 1372.7 | 92.8 | 30.9 | Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. | J Garnier, D J Osguthorpe, B Robson | J Mol Biol | 1978 | 642007 | Yes |
| 2865 | 2745 | 1372.5 | 184.1 | 92.0 | Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. | R B Gustilo, J T Anderson | J Bone Joint Surg Am | 1976 | 773941 | Yes |
| 2866 | 1372 | 1372.0 | 36.8 | 36.8 | Automatic quantitation of localized in vivo 1H spectra with LCModel. | S W Provencher | NMR Biomed | 2001 | 11410943 | Yes |
| 2867 | 1371 | 1371.0 | 54.6 | 54.6 | Geriatric Depression Scale. | J A Yesavage | Psychopharmacol Bull | 1988 | 3249773 | Yes |
| 2868 | 1371 | 1371.0 | 38.7 | 38.7 | Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. | R M Sapolsky | Arch Gen Psychiatry | 2000 | 11015810 | No |
| 2869 | 1371 | 1371.0 | 38.9 | 38.9 | Water as an active constituent in cell biology. | Philip Ball | Chem Rev | 2008 | 18095715 | No |
| 2870 | 2741 | 1370.5 | 77.3 | 38.6 | Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis). | S M Rogers, L Bernatchez | Mol Ecol | 2005 | 15660930 | Yes |
| 2871 | 1370 | 1370.0 | 47.8 | 47.8 | An application of prefrontal cortex function theory to cognitive aging. | R L West | Psychol Bull | 1996 | 8831298 | No |
| 2872 | 2740 | 1370.0 | 50.3 | 25.1 | Rab proteins as membrane organizers. | M Zerial, H McBride | Nat Rev Mol Cell Biol | 2001 | 11252952 | No |
| 2873 | 1370 | 1370.0 | 31.0 | 31.0 | Assortative mixing in networks. | M E J Newman | Phys Rev Lett | 2002 | 12443515 | Yes |
| 2874 | 2739 | 1369.5 | 56.1 | 28.1 | Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. | P J Southern, P Berg | J Mol Appl Genet | 1982 | 6286831 | Yes |
| 2875 | 2739 | 1369.5 | 0.0 | 0.0 | A Generalization Of The Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography. | H Vandendool, P D Kratz | J Chromatogr | 1963 | 14062605 | Yes |
| 2876 | 4107 | 1369.0 | 105.3 | 35.1 | Atomic force microscope. | G Binnig, C F Quate, C Gerber | Phys Rev Lett | 1986 | 10033323 | Yes |
| 2877 | 4107 | 1369.0 | 147.1 | 49.0 | Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. | B K Matuszewski, M L Constanzer, C M Chavez-Eng | Anal Chem | 2003 | 12964746 | Yes |
| 2878 | 1368 | 1368.0 | 40.5 | 40.5 | Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. | S G Johnsen | Hormones | 1970 | 5527187 | Yes |
| 2879 | 2736 | 1368.0 | 78.8 | 39.4 | Humans integrate visual and haptic information in a statistically optimal fashion. | Marc O Ernst, Martin S Banks | Nature | 2002 | 11807554 | Yes |
| 2880 | 1367 | 1367.0 | 29.6 | 29.6 | Hypoxia, HIF1 and glucose metabolism in the solid tumour. | Nicholas C Denko | Nat Rev Cancer | 2008 | 19143055 | No |
| 2881 | 4098 | 1366.0 | 216.7 | 72.2 | Assessing coping strategies: a theoretically based approach. | C S Carver, M F Scheier, J K Weintraub | J Pers Soc Psychol | 1989 | 2926629 | Yes |
| 2882 | 1366 | 1366.0 | 48.2 | 48.2 | Interleukin-1. | C A Dinarello | Rev Infect Dis | 1984 | 6369481 | No |
| 2883 | 1366 | 1366.0 | 0.0 | 0.0 | An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. | O Smithies | Biochem J | 1959 | 13638269 | Yes |
| 2884 | 2732 | 1366.0 | 109.3 | 54.6 | Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. | Michael A Gimbrone, Guillermo Garcia-Cardena | Circ Res | 2016 | 26892962 | No |
| 2885 | 6828 | 1365.6 | 198.4 | 39.7 | Quantitative assessment of tactile allodynia in the rat paw. | S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L Yaksh | J Neurosci Methods | 1994 | 7990513 | Yes |
| 2886 | 2731 | 1365.5 | 74.5 | 37.2 | Hydrogels for tissue engineering: scaffold design variables and applications. | Jeanie L Drury, David J Mooney | Biomaterials | 2003 | 12922147 | No |
| 2887 | 1365 | 1365.0 | 48.7 | 48.7 | Multiple calcium channels and neuronal function. | R J Miller | Science | 1987 | 2432656 | No |
| 2888 | 5458 | 1364.5 | 129.9 | 32.5 | Quantitative monitoring of gene expression patterns with a complementary DNA microarray. | M Schena, D Shalon, R W Davis, P O Brown | Science | 1995 | 7569999 | Yes |
| 2889 | 2729 | 1364.5 | 81.9 | 41.0 | What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? | K C Berridge, T E Robinson | Brain Res Brain Res Rev | 1998 | 9858756 | No |
| 2890 | 1364 | 1364.0 | 61.6 | 61.6 | A cochlear frequency-position function for several species--29 years later. | D D Greenwood | J Acoust Soc Am | 1990 | 2373794 | Yes |
| 2891 | 1364 | 1364.0 | 51.6 | 51.6 | The life and times of the Enterococcus. | B E Murray | Clin Microbiol Rev | 1990 | 2404568 | No |
| 2892 | 1363 | 1363.0 | 43.1 | 43.1 | Neurotransmitters and neuromodulators in the basal ganglia. | A M Graybiel | Trends Neurosci | 1990 | 1695398 | No |
| 2893 | 1363 | 1363.0 | 0.0 | 0.0 | Blood gas calculator. | J W Severinghaus | J Appl Physiol | 1966 | 5912737 | Yes |
| 2894 | 1363 | 1363.0 | 43.1 | 43.1 | The phenomenon of the acute phase response. | I Kushner | Ann N Y Acad Sci | 1982 | 7046585 | No |
| 2895 | 1362 | 1362.0 | 41.2 | 41.2 | Renin-angiotensin system: biochemistry and mechanisms of action. | M J Peach | Physiol Rev | 1977 | 191856 | No |
| 2896 | 2724 | 1362.0 | 70.6 | 35.3 | A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. | B G Durie, S E Salmon | Cancer | 1975 | 1182674 | Yes |
| 2897 | 2723 | 1361.5 | 58.1 | 29.1 | Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. | M Zuker, P Stiegler | Nucleic Acids Res | 1981 | 6163133 | Yes |
| 2898 | 1361 | 1361.0 | 29.1 | 29.1 | The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. | G B Morin | Cell | 1989 | 2805070 | Yes |
| 2899 | 1361 | 1361.0 | 26.3 | 26.3 | Chromosomal translocations in human cancer. | T H Rabbitts | Nature | 1994 | 7969446 | No |
| 2900 | 1361 | 1361.0 | 27.7 | 27.7 | Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. | Sean B Carroll | Cell | 2008 | 18614008 | Yes |
| 2901 | 4082 | 1360.7 | 150.1 | 50.0 | The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting. | C Kirschbaum, K M Pirke, D H Hellhammer | Neuropsychobiology | 1993 | 8255414 | Yes |
| 2902 | 1360 | 1360.0 | 47.3 | 47.3 | The theoretical bases of indirect calorimetry: a review. | E Ferrannini | Metabolism | 1988 | 3278194 | No |
| 2903 | 1360 | 1360.0 | 0.0 | 0.0 | Disconnexion syndromes in animals and man. I. | N Geschwind | Brain | 1965 | 5318481 | No |
| 2904 | 1360 | 1360.0 | 27.7 | 27.7 | Dimerization of cell surface receptors in signal transduction. | C H Heldin | Cell | 1995 | 7834741 | No |
| 2905 | 1360 | 1360.0 | 29.6 | 29.6 | The advantages and disadvantages of being polyploid. | Luca Comai | Nat Rev Genet | 2005 | 16304599 | No |
| 2906 | 1359 | 1359.0 | 35.5 | 35.5 | Thioredoxin and glutaredoxin systems. | A Holmgren | J Biol Chem | 1989 | 2668278 | No |
| 2907 | 2717 | 1358.5 | 62.5 | 31.2 | Cellular processing of platinum anticancer drugs. | Dong Wang, Stephen J Lippard | Nat Rev Drug Discov | 2005 | 15789122 | No |
| 2908 | 4075 | 1358.3 | 130.5 | 43.5 | Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. | Geoffrey R Norman, Jeff A Sloan, Kathleen W Wyrwich | Med Care | 2003 | 12719681 | Yes |
| 2909 | 1358 | 1358.0 | 0.0 | 0.0 | Effects of varying the vehicle for OsO4 in tissue fixation. | J B Caulfield | J Biophys Biochem Cytol | 1957 | 13475399 | Yes |
| 2910 | 4073 | 1357.7 | 108.8 | 36.3 | Use and abuse of HOMA modeling. | Tara M Wallace, Jonathan C Levy, David R Matthews | Diabetes Care | 2004 | 15161807 | No |
| 2911 | 2715 | 1357.5 | 72.4 | 36.2 | Apoptosis, oncosis, and necrosis. An overview of cell death. | G Majno, I Joris | Am J Pathol | 1995 | 7856735 | No |
| 2912 | 2714 | 1357.0 | 59.1 | 29.6 | Liver regeneration. | G K Michalopoulos, M C DeFrances | Science | 1997 | 9082986 | No |
| 2913 | 4069 | 1356.3 | 145.7 | 48.6 | Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. | Dmitry B Zorov, Magdalena Juhaszova, Steven J Sollott | Physiol Rev | 2014 | 24987008 | No |
| 2914 | 1356 | 1356.0 | 45.8 | 45.8 | Carnitine--metabolism and functions. | J Bremer | Physiol Rev | 1983 | 6361812 | No |
| 2915 | 2712 | 1356.0 | 64.4 | 32.2 | A comparison of bayesian methods for haplotype reconstruction from population genotype data. | Matthew Stephens, Peter Donnelly | Am J Hum Genet | 2003 | 14574645 | Yes |
| 2916 | 2711 | 1355.5 | 63.7 | 31.9 | The RXR heterodimers and orphan receptors. | D J Mangelsdorf, R M Evans | Cell | 1995 | 8521508 | No |
| 2917 | 2711 | 1355.5 | 69.2 | 34.6 | Drug delivery systems: entering the mainstream. | Theresa M Allen, Pieter R Cullis | Science | 2004 | 15031496 | Yes |
| 2918 | 4066 | 1355.3 | 0.0 | 0.0 | Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. | D D Sabatini, K Bensch, R J Barrnett | J Cell Biol | 1963 | 13975866 | Yes |
| 2919 | 1355 | 1355.0 | 0.0 | 0.0 | The nature and significance of platelet products in human plasma. | P Wolf | Br J Haematol | 1967 | 6025241 | Yes |
| 2920 | 1355 | 1355.0 | 59.5 | 59.5 | Molecular pathology of schizophrenia: more than one disease process? | T J Crow | Br Med J | 1980 | 6101544 | No |
| 2921 | 1355 | 1355.0 | 40.5 | 40.5 | The effects of stressful life events on depression. | R C Kessler | Annu Rev Psychol | 1997 | 9046559 | No |
| 2922 | 1355 | 1355.0 | 37.4 | 37.4 | N-heterocyclic carbenes: a new concept in organometallic catalysis. | Wolfgang A Herrmann | Angew Chem Int Ed Engl | 2002 | 19750753 | Yes |
| 2923 | 1354 | 1354.0 | 37.2 | 37.2 | Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. | S L Friedman | N Engl J Med | 1993 | 8502273 | No |
| 2924 | 1354 | 1354.0 | 33.3 | 33.3 | Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. | R Balfour Sartor | Nat Clin Pract Gastroenterol Hepatol | 2006 | 16819502 | No |
| 2925 | 1354 | 1354.0 | 39.6 | 39.6 | Electrochemical glucose biosensors. | Joseph Wang | Chem Rev | 2008 | 18154363 | No |
| 2926 | 2708 | 1354.0 | 113.6 | 56.8 | Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. | Ian Janssen, Allana G Leblanc | Int J Behav Nutr Phys Act | 2010 | 20459784 | Yes |
| 2927 | 2707 | 1353.5 | 56.2 | 28.1 | Tumorigenesis and the angiogenic switch. | Gabriele Bergers, Laura E Benjamin | Nat Rev Cancer | 2003 | 12778130 | No |
| 2928 | 4060 | 1353.3 | 100.1 | 33.4 | Dystrophin: the protein product of the Duchenne muscular dystrophy locus. | E P Hoffman, R H Brown, L M Kunkel | Cell | 1987 | 3319190 | Yes |
| 2929 | 1353 | 1353.0 | 55.8 | 55.8 | Bone "mass" and the "mechanostat": a proposal. | H M Frost | Anat Rec | 1987 | 3688455 | Yes |
| 2930 | 1353 | 1353.0 | 32.4 | 32.4 | Neurobiology of Pavlovian fear conditioning. | S Maren | Annu Rev Neurosci | 2001 | 11520922 | No |
| 2931 | 2705 | 1352.5 | 112.3 | 56.1 | The Posttraumatic Growth Inventory: measuring the positive legacy of trauma. | R G Tedeschi, L G Calhoun | J Trauma Stress | 1996 | 8827649 | Yes |
| 2932 | 4057 | 1352.3 | 163.3 | 54.4 | Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. | Antonio Ayala, Mario F Munoz, Sandro Arguelles | Oxid Med Cell Longev | 2014 | 24999379 | No |
| 2933 | 1352 | 1352.0 | 44.2 | 44.2 | A practical solution to the pervasive problems of p values. | Eric-Jan Wagenmakers | Psychon Bull Rev | 2007 | 18087943 | Yes |
| 2934 | 4055 | 1351.7 | 107.2 | 35.7 | Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? | Dunyaporn Trachootham, Jerome Alexandre, Peng Huang | Nat Rev Drug Discov | 2009 | 19478820 | No |
| 2935 | 2702 | 1351.0 | 74.1 | 37.0 | Neuronal plasticity: increasing the gain in pain. | C J Woolf, M W Salter | Science | 2000 | 10846153 | No |
| 2936 | 2702 | 1351.0 | 60.3 | 30.1 | The pathophysiology of mitochondrial cell death. | Douglas R Green, Guido Kroemer | Science | 2004 | 15286356 | No |
| 2937 | 1351 | 1351.0 | 28.5 | 28.5 | Fibrotic disease and the T(H)1/T(H)2 paradigm. | Thomas A Wynn | Nat Rev Immunol | 2004 | 15286725 | No |
| 2938 | 5404 | 1351.0 | 150.3 | 37.6 | Measurement of the elastic properties and intrinsic strength of monolayer graphene. | Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James Hone | Science | 2008 | 18635798 | Yes |
| 2939 | 1351 | 1351.0 | 0.0 | 0.0 | A simple objective technique for measuring flexibility in thinking. | E A Berg | J Gen Psychol | 1948 | 18889466 | Yes |
| 2940 | 2701 | 1350.5 | 58.2 | 29.1 | Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. | G Blobel, B Dobberstein | J Cell Biol | 1975 | 811671 | Yes |
| 2941 | 1350 | 1350.0 | 0.0 | 0.0 | Intra-sexual selection in Drosophila. | A J Bateman | Heredity (Edinb) | 1948 | 18103134 | Yes |
| 2942 | 2699 | 1349.5 | 55.0 | 27.5 | Proliferation, cell cycle and apoptosis in cancer. | G I Evan, K H Vousden | Nature | 2001 | 11357141 | No |
| 2943 | 2699 | 1349.5 | 77.2 | 38.6 | Meeting of minds: the medial frontal cortex and social cognition. | David M Amodio, Chris D Frith | Nat Rev Neurosci | 2006 | 16552413 | No |
| 2944 | 2698 | 1349.0 | 76.8 | 38.4 | Ageing and Parkinson's disease: substantia nigra regional selectivity. | J M Fearnley, A J Lees | Brain | 1991 | 1933245 | Yes |
| 2945 | 1349 | 1349.0 | 0.0 | 0.0 | A simple ultraviolet spectrophotometric method for the determination of protein. | W J Waddell | J Lab Clin Med | 1956 | 13346201 | Yes |
| 2946 | 2698 | 1349.0 | 75.7 | 37.9 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. | Ajay Kumar Gupta, Mona Gupta | Biomaterials | 2005 | 15626447 | No |
| 2947 | 1349 | 1349.0 | 31.8 | 31.8 | Transcriptional paradigms in mammalian mitochondrial biogenesis and function. | Richard C Scarpulla | Physiol Rev | 2008 | 18391175 | No |
| 2948 | 2697 | 1348.5 | 0.0 | 0.0 | Functions of lysosomes. | C De Duve, R Wattiaux | Annu Rev Physiol | 1966 | 5322983 | No |
| 2949 | 1348 | 1348.0 | 35.3 | 35.3 | Plasmonics: merging photonics and electronics at nanoscale dimensions. | Ekmel Ozbay | Science | 2006 | 16410515 | Yes |
| 2950 | 1348 | 1348.0 | 56.7 | 56.7 | Cystic fibrosis. | J Stuart Elborn | Lancet | 2016 | 27140670 | No |
| 2951 | 2695 | 1347.5 | 62.3 | 31.1 | Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. | Kornelia Polyak, Robert A Weinberg | Nat Rev Cancer | 2009 | 19262571 | No |
| 2952 | 1347 | 1347.0 | 52.7 | 52.7 | Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. | K Satoh | Clin Chim Acta | 1978 | 719890 | Yes |
| 2953 | 1347 | 1347.0 | 30.4 | 30.4 | Human papillomavirus and cervical cancer. | Eileen M Burd | Clin Microbiol Rev | 2003 | 12525422 | No |
| 2954 | 2694 | 1347.0 | 94.6 | 47.3 | Self-management education: history, definition, outcomes, and mechanisms. | Kate R Lorig, Halsted Holman | Ann Behav Med | 2003 | 12867348 | No |
| 2955 | 1347 | 1347.0 | 44.0 | 44.0 | Delirium in older persons. | Sharon K Inouye | N Engl J Med | 2006 | 16540616 | No |
| 2956 | 1347 | 1347.0 | 88.4 | 88.4 | Multicollinearity and misleading statistical results. | Jong Hae Kim | Korean J Anesthesiol | 2019 | 31304696 | Yes |
| 2957 | 2692 | 1346.0 | 85.8 | 42.9 | Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. | G J Miller, N E Miller | Lancet | 1975 | 46338 | Yes |
| 2958 | 1346 | 1346.0 | 58.8 | 58.8 | Biomaterial-centered infection: microbial adhesion versus tissue integration. | A G Gristina | Science | 1987 | 3629258 | Yes |
| 2959 | 2692 | 1346.0 | 87.2 | 43.6 | Prostaglandins and inflammation. | Emanuela Ricciotti, Garret A FitzGerald | Arterioscler Thromb Vasc Biol | 2011 | 21508345 | No |
| 2960 | 1346 | 1346.0 | 50.6 | 50.6 | Epidemiology and risk factors for IBD. | Ashwin N Ananthakrishnan | Nat Rev Gastroenterol Hepatol | 2015 | 25732745 | No |
| 2961 | 1346 | 1346.0 | 106.6 | 106.6 | Complex heatmap visualization. | Zuguang Gu | Imeta | 2022 | 38868715 | Yes |
| 2962 | 2691 | 1345.5 | 84.5 | 42.2 | Multiple significance tests: the Bonferroni method. | J M Bland, D G Altman | BMJ | 1995 | 7833759 | Yes |
| 2963 | 1345 | 1345.0 | 47.5 | 47.5 | Neuropeptide Y: complete amino acid sequence of the brain peptide. | K Tatemoto | Proc Natl Acad Sci U S A | 1982 | 6957876 | Yes |
| 2964 | 1345 | 1345.0 | 62.3 | 62.3 | Error in medicine. | L L Leape | JAMA | 1994 | 7503827 | Yes |
| 2965 | 2690 | 1345.0 | 64.1 | 32.0 | NF-kappa B: ten years after. | P A Baeuerle, D Baltimore | Cell | 1996 | 8858144 | No |
| 2966 | 1345 | 1345.0 | 41.0 | 41.0 | The biochemistry and medical significance of the flavonoids. | Bent H Havsteen | Pharmacol Ther | 2002 | 12453566 | No |
| 2967 | 1345 | 1345.0 | 31.3 | 31.3 | Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. | William C Aird | Circ Res | 2007 | 17272818 | No |
| 2968 | 1345 | 1345.0 | 38.5 | 38.5 | Plant productivity and environment. | J S Boyer | Science | 1982 | 17808529 | Yes |
| 2969 | 2689 | 1344.5 | 74.7 | 37.4 | Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. | Barry J Everitt, Trevor W Robbins | Nat Neurosci | 2005 | 16251991 | No |
| 2970 | 2689 | 1344.5 | 71.4 | 35.7 | Mechanisms of mitophagy. | Richard J Youle, Derek P Narendra | Nat Rev Mol Cell Biol | 2011 | 21179058 | No |
| 2971 | 1344 | 1344.0 | 36.4 | 36.4 | Optimal experimental design for event-related fMRI. | A M Dale | Hum Brain Mapp | 1999 | 10524601 | Yes |
| 2972 | 1344 | 1344.0 | 33.5 | 33.5 | Oxyradicals and DNA damage. | L J Marnett | Carcinogenesis | 2000 | 10688856 | No |
| 2973 | 1344 | 1344.0 | 48.1 | 48.1 | Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. | L Sjostrom | J Intern Med | 2013 | 23163728 | No |
| 2974 | 2687 | 1343.5 | 0.0 | 0.0 | Surgical risk as related to time of intervention in the repair of intracranial aneurysms. | W E Hunt, R M Hess | J Neurosurg | 1968 | 5635959 | Yes |
| 2975 | 2686 | 1343.0 | 73.1 | 36.5 | BODIPY dyes and their derivatives: syntheses and spectroscopic properties. | Aurore Loudet, Kevin Burgess | Chem Rev | 2007 | 17924696 | Yes |
| 2976 | 4029 | 1343.0 | 148.4 | 49.5 | Ecological momentary assessment. | Saul Shiffman, Arthur A Stone, Michael R Hufford | Annu Rev Clin Psychol | 2008 | 18509902 | No |
| 2977 | 1343 | 1343.0 | 32.4 | 32.4 | Molecular genetics of colorectal cancer. | Eric R Fearon | Annu Rev Pathol | 2011 | 21090969 | No |
| 2978 | 2686 | 1343.0 | 86.8 | 43.4 | The complexity of NF-κB signaling in inflammation and cancer. | Bastian Hoesel, Johannes A Schmid | Mol Cancer | 2013 | 23915189 | No |
| 2979 | 1342 | 1342.0 | 36.3 | 36.3 | Fibronectin and its receptors. | E Ruoslahti | Annu Rev Biochem | 1988 | 2972252 | No |
| 2980 | 1342 | 1342.0 | 35.7 | 35.7 | Supported membranes: scientific and practical applications. | E Sackmann | Science | 1996 | 8539599 | No |
| 2981 | 1342 | 1342.0 | 23.0 | 23.0 | Cancer susceptibility and the functions of BRCA1 and BRCA2. | Ashok R Venkitaraman | Cell | 2002 | 11832208 | No |
| 2982 | 1342 | 1342.0 | 29.2 | 29.2 | The stem-cell niche as an entity of action. | David T Scadden | Nature | 2006 | 16810242 | No |
| 2983 | 2683 | 1341.5 | 50.3 | 25.1 | New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. | R D Gietz, A Sugino | Gene | 1988 | 3073106 | Yes |
| 2984 | 2682 | 1341.0 | 60.7 | 30.4 | Prediction of the secondary structure of proteins from their amino acid sequence. | P Y Chou, G D Fasman | Adv Enzymol Relat Areas Mol Biol | 1978 | 364941 | No |
| 2985 | 1341 | 1341.0 | 36.3 | 36.3 | The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. | K Kuwajima | Proteins | 1989 | 2695928 | No |
| 2986 | 2682 | 1341.0 | 102.0 | 51.0 | Reading senseless sentences: brain potentials reflect semantic incongruity. | M Kutas, S A Hillyard | Science | 1980 | 7350657 | Yes |
| 2987 | 2682 | 1341.0 | 0.0 | 0.0 | Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. | R R Guillard, J H Ryther | Can J Microbiol | 1962 | 13902807 | Yes |
| 2988 | 2681 | 1340.5 | 62.4 | 31.2 | Establishing, maintaining and modifying DNA methylation patterns in plants and animals. | Julie A Law, Steven E Jacobsen | Nat Rev Genet | 2010 | 20142834 | No |
| 2989 | 1340 | 1340.0 | 40.7 | 40.7 | Depression in the elderly. | George S Alexopoulos | Lancet | 2005 | 15936426 | No |
| 2990 | 1340 | 1340.0 | 38.5 | 38.5 | Rethinking schizophrenia. | Thomas R Insel | Nature | 2010 | 21068826 | No |
| 2991 | 4019 | 1339.7 | 117.4 | 39.1 | Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. | Gunter Oberdorster, Eva Oberdorster, Jan Oberdorster | Environ Health Perspect | 2005 | 16002369 | No |
| 2992 | 2679 | 1339.5 | 59.4 | 29.7 | The Polycomb complex PRC2 and its mark in life. | Raphael Margueron, Danny Reinberg | Nature | 2011 | 21248841 | No |
| 2993 | 4017 | 1339.0 | 121.6 | 40.5 | The functional anatomy of basal ganglia disorders. | R L Albin, A B Young, J B Penney | Trends Neurosci | 1989 | 2479133 | No |
| 2994 | 2678 | 1339.0 | 59.0 | 29.5 | Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. | Eugenia E Calle, Rudolf Kaaks | Nat Rev Cancer | 2004 | 15286738 | No |
| 2995 | 2676 | 1338.0 | 83.2 | 41.6 | A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. | A Ennaceur, J Delacour | Behav Brain Res | 1988 | 3228475 | Yes |
| 2996 | 1338 | 1338.0 | 0.0 | 0.0 | Stereological principles for morphometry in electron microscopic cytology. | E R Weibel | Int Rev Cytol | 1969 | 4899604 | No |
| 2997 | 2676 | 1338.0 | 48.3 | 24.1 | DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. | Christopher J Bakkenist, Michael B Kastan | Nature | 2003 | 12556884 | Yes |
| 2998 | 1338 | 1338.0 | 0.0 | 0.0 | A modified procedure for lead staining of thin sections. | G Millonig | J Biophys Biochem Cytol | 1961 | 14474176 | Yes |
| 2999 | 1338 | 1338.0 | 40.9 | 40.9 | pegas: an R package for population genetics with an integrated-modular approach. | Emmanuel Paradis | Bioinformatics | 2010 | 20080509 | Yes |
| 3000 | 2676 | 1338.0 | 100.8 | 50.4 | Comparative Protein Structure Modeling Using MODELLER. | Benjamin Webb, Andrej Sali | Curr Protoc Bioinformatics | 2016 | 27322406 | Yes |
| 3001 | 2675 | 1337.5 | 62.6 | 31.3 | Can the pharmaceutical industry reduce attrition rates? | Ismail Kola, John Landis | Nat Rev Drug Discov | 2004 | 15286737 | No |
| 3002 | 8023 | 1337.2 | 193.0 | 32.2 | Staging of brain pathology related to sporadic Parkinson's disease. | Heiko Braak, Kelly Del Tredici, Udo Rub, Rob A I De Vos, Ernst N H Jansen Steur, Eva Braak | Neurobiol Aging | 2003 | 12498954 | Yes |
| 3003 | 1337 | 1337.0 | 35.5 | 35.5 | Plant salt tolerance. | J K Zhu | Trends Plant Sci | 2001 | 11173290 | Yes |
| 3004 | 1337 | 1337.0 | 40.0 | 40.0 | Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. | Antoine Bechara | Nat Neurosci | 2005 | 16251988 | No |
| 3005 | 1337 | 1337.0 | 0.0 | 0.0 | Limitations of the application of fourfold table analysis to hospital data. | J Berkson | Biometrics | 1946 | 21001024 | Yes |
| 3006 | 2674 | 1337.0 | 635.4 | 317.7 | Interactive Tree of Life (iTOL) v6: recent updates to the phylogenetic tree display and annotation tool. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2024 | 38613393 | Yes |
| 3007 | 1336 | 1336.0 | 30.9 | 30.9 | Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. | W D Snider | Cell | 1994 | 8205613 | No |
| 3008 | 1336 | 1336.0 | 52.6 | 52.6 | Intention-to-treat concept: A review. | Sandeep K Gupta | Perspect Clin Res | 2011 | 21897887 | Yes |
| 3009 | 2671 | 1335.5 | 76.3 | 38.1 | Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. | E Engvall, P Perlmann | J Immunol | 1972 | 4113792 | Yes |
| 3010 | 2671 | 1335.5 | 0.0 | 0.0 | Further improvements in the plaque technique for detecting single antibody-forming cells. | A J Cunningham, A Szenberg | Immunology | 1968 | 5653817 | Yes |
| 3011 | 2671 | 1335.5 | 86.8 | 43.4 | Infernal 1.1: 100-fold faster RNA homology searches. | Eric P Nawrocki, Sean R Eddy | Bioinformatics | 2013 | 24008419 | Yes |
| 3012 | 5341 | 1335.2 | 135.2 | 33.8 | Improved prediction of signal peptides: SignalP 3.0. | Jannick Dyrlov Bendtsen, Henrik Nielsen, Gunnar Von Heijne, Soren Brunak | J Mol Biol | 2004 | 15223320 | Yes |
| 3013 | 2669 | 1334.5 | 65.2 | 32.6 | ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. | Benoit D'Autreaux, Michel B Toledano | Nat Rev Mol Cell Biol | 2007 | 17848967 | No |
| 3014 | 2668 | 1334.0 | 67.8 | 33.9 | Toxoplasmosis. | J G Montoya, O Liesenfeld | Lancet | 2004 | 15194258 | No |
| 3015 | 4002 | 1334.0 | 96.2 | 32.1 | Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. | Sang-Dong Yoo, Young-Hee Cho, Jen Sheen | Nat Protoc | 2007 | 17585298 | Yes |
| 3016 | 1334 | 1334.0 | 50.4 | 50.4 | Considerations in determining sample size for pilot studies. | Melody A Hertzog | Res Nurs Health | 2008 | 18183564 | No |
| 3017 | 6668 | 1333.6 | 337.1 | 67.4 | Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. | N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W Stitt | J Rheumatol | 1988 | 3068365 | Yes |
| 3018 | 2667 | 1333.5 | 91.3 | 45.6 | Oxidative mechanisms in the toxicity of metal ions. | S J Stohs, D Bagchi | Free Radic Biol Med | 1995 | 7744317 | No |
| 3019 | 4000 | 1333.3 | 149.5 | 49.8 | Qualitative research in health care. Analysing qualitative data. | C Pope, S Ziebland, N Mays | BMJ | 2000 | 10625273 | No |
| 3020 | 1333 | 1333.0 | 40.0 | 40.0 | What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. | Michael A Babyak | Psychosom Med | 2004 | 15184705 | Yes |
| 3021 | 1333 | 1333.0 | 0.0 | 0.0 | On the local reactions of the arterial wall to changes of internal pressure. | W M Bayliss | J Physiol | 1902 | 16992618 | Yes |
| 3022 | 3998 | 1332.7 | 115.8 | 38.6 | Development and applications of CRISPR-Cas9 for genome engineering. | Patrick D Hsu, Eric S Lander, Feng Zhang | Cell | 2014 | 24906146 | No |
| 3023 | 2665 | 1332.5 | 75.2 | 37.6 | Heterogeneous photocatalyst materials for water splitting. | Akihiko Kudo, Yugo Miseki | Chem Soc Rev | 2009 | 19088977 | Yes |
| 3024 | 2665 | 1332.5 | 114.2 | 57.1 | Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. | Douglas J Morrison, Tom Preston | Gut Microbes | 2016 | 26963409 | No |
| 3025 | 1332 | 1332.0 | 33.3 | 33.3 | The mitochondrial electron transport and oxidative phosphorylation system. | Y Hatefi | Annu Rev Biochem | 1985 | 2862839 | No |
| 3026 | 1332 | 1332.0 | 29.5 | 29.5 | VEGF as a key mediator of angiogenesis in cancer. | Peter Carmeliet | Oncology | 2005 | 16301830 | No |
| 3027 | 1332 | 1332.0 | 38.5 | 38.5 | Production and scavenging of reactive oxygen species in chloroplasts and their functions. | Kozi Asada | Plant Physiol | 2006 | 16760493 | Yes |
| 3028 | 1332 | 1332.0 | 38.9 | 38.9 | Transcranial magnetic stimulation: a primer. | Mark Hallett | Neuron | 2007 | 17640522 | No |
| 3029 | 3995 | 1331.7 | 104.8 | 34.9 | Matrix metalloproteinases: regulators of the tumor microenvironment. | Kai Kessenbrock, Vicki Plaks, Zena Werb | Cell | 2010 | 20371345 | No |
| 3030 | 1331 | 1331.0 | 63.9 | 63.9 | New norms of upper limb fat and muscle areas for assessment of nutritional status. | A R Frisancho | Am J Clin Nutr | 1981 | 6975564 | Yes |
| 3031 | 1331 | 1331.0 | 0.0 | 0.0 | A production of amino acids under possible primitive earth conditions. | S L Miller | Science | 1953 | 13056598 | Yes |
| 3032 | 1331 | 1331.0 | 0.0 | 0.0 | Cellular resistance to infection. | G B MacKaness | J Exp Med | 1962 | 14467923 | Yes |
| 3033 | 5322 | 1330.5 | 129.2 | 32.3 | Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. | D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli | J Biol Chem | 1977 | 320200 | Yes |
| 3034 | 1330 | 1330.0 | 52.6 | 52.6 | Free-radical mechanisms in tissue injury. | T F Slater | Biochem J | 1984 | 6383353 | No |
| 3035 | 1330 | 1330.0 | 0.0 | 0.0 | Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. | G D Winter | Nature | 1962 | 14007593 | Yes |
| 3036 | 1330 | 1330.0 | 46.0 | 46.0 | Social support and health: a review of physiological processes potentially underlying links to disease outcomes. | Bert N Uchino | J Behav Med | 2006 | 16758315 | No |
| 3037 | 1330 | 1330.0 | 66.7 | 66.7 | Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. | Hector F Escobar-Morreale | Nat Rev Endocrinol | 2018 | 29569621 | No |
| 3038 | 3989 | 1329.7 | 142.4 | 47.5 | PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. | J W Varni, M Seid, P S Kurtin | Med Care | 2001 | 11468499 | Yes |
| 3039 | 2659 | 1329.5 | 105.0 | 52.5 | A simple method to assess exercise behavior in the community. | G Godin, R J Shephard | Can J Appl Sport Sci | 1985 | 4053261 | Yes |
| 3040 | 2659 | 1329.5 | 0.0 | 0.0 | Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. | J Altman, G D Das | J Comp Neurol | 1965 | 5861717 | Yes |
| 3041 | 2659 | 1329.5 | 68.6 | 34.3 | Interneurons of the hippocampus. | T F Freund, G Buzsaki | Hippocampus | 1996 | 8915675 | No |
| 3042 | 6647 | 1329.4 | 236.3 | 47.3 | Enzymatic determination of total serum cholesterol. | C C Allain, L S Poon, C S Chan, W Richmond, P C Fu | Clin Chem | 1974 | 4818200 | Yes |
| 3043 | 3988 | 1329.3 | 111.0 | 37.0 | FastTree: computing large minimum evolution trees with profiles instead of a distance matrix. | Morgan N Price, Paramvir S Dehal, Adam P Arkin | Mol Biol Evol | 2009 | 19377059 | Yes |
| 3044 | 2658 | 1329.0 | 102.5 | 51.2 | Efficacy of the Theory of Planned Behaviour: a meta-analytic review. | C J Armitage, M Conner | Br J Soc Psychol | 2001 | 11795063 | Yes |
| 3045 | 3986 | 1328.7 | 206.3 | 68.8 | Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. | F Guillemin, C Bombardier, D Beaton | J Clin Epidemiol | 1993 | 8263569 | No |
| 3046 | 2657 | 1328.5 | 78.0 | 39.0 | Are the dorsal and ventral hippocampus functionally distinct structures? | Michael S Fanselow, Hong-Wei Dong | Neuron | 2010 | 20152109 | No |
| 3047 | 1328 | 1328.0 | 27.7 | 27.7 | Understanding the odd science of aging. | Thomas B L Kirkwood | Cell | 2005 | 15734677 | No |
| 3048 | 1328 | 1328.0 | 58.7 | 58.7 | The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. | L S Radloff | J Youth Adolesc | 1991 | 24265004 | Yes |
| 3049 | 2654 | 1327.0 | 58.4 | 29.2 | The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. | J Shine, L Dalgarno | Proc Natl Acad Sci U S A | 1974 | 4598299 | Yes |
| 3050 | 3980 | 1326.7 | 100.4 | 33.5 | The p53 tumour suppressor gene. | A J Levine, J Momand, C A Finlay | Nature | 1991 | 2046748 | No |
| 3051 | 13263 | 1326.3 | 352.4 | 35.2 | Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. | M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, F C Marini, D S Krause, R J Deans, A Keating, D J Prockop, Em Horwitz | Cytotherapy | 2006 | 16923606 | Yes |
| 3052 | 1326 | 1326.0 | 36.0 | 36.0 | The aryl hydrocarbon receptor complex. | O Hankinson | Annu Rev Pharmacol Toxicol | 1995 | 7598497 | No |
| 3053 | 2652 | 1326.0 | 62.3 | 31.1 | Integrins and signal transduction pathways: the road taken. | E A Clark, J S Brugge | Science | 1995 | 7716514 | No |
| 3054 | 1326 | 1326.0 | 49.5 | 49.5 | Risk and maintenance factors for eating pathology: a meta-analytic review. | Eric Stice | Psychol Bull | 2002 | 12206196 | No |
| 3055 | 1326 | 1326.0 | 30.0 | 30.0 | r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. | Michael J Sanderson | Bioinformatics | 2003 | 12538260 | Yes |
| 3056 | 2651 | 1325.5 | 70.6 | 35.3 | Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. | M E Feder, G E Hofmann | Annu Rev Physiol | 1999 | 10099689 | No |
| 3057 | 1325 | 1325.0 | 49.1 | 49.1 | The LMS method for constructing normalized growth standards. | T J Cole | Eur J Clin Nutr | 1990 | 2354692 | Yes |
| 3058 | 2649 | 1324.5 | 54.8 | 27.4 | ERBB receptors and cancer: the complexity of targeted inhibitors. | Nancy E Hynes, Heidi A Lane | Nat Rev Cancer | 2005 | 15864276 | No |
| 3059 | 1324 | 1324.0 | 88.9 | 88.9 | The problem of rigor in qualitative research. | M Sandelowski | ANS Adv Nurs Sci | 1986 | 3083765 | Yes |
| 3060 | 1324 | 1324.0 | 35.2 | 35.2 | Primate anterior cingulate cortex: where motor control, drive and cognition interface. | T Paus | Nat Rev Neurosci | 2001 | 11389475 | No |
| 3061 | 2648 | 1324.0 | 59.5 | 29.8 | Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. | William G Kaelin, Peter J Ratcliffe | Mol Cell | 2008 | 18498744 | No |
| 3062 | 2647 | 1323.5 | 76.9 | 38.5 | Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. | I Chopra, M Roberts | Microbiol Mol Biol Rev | 2001 | 11381101 | Yes |
| 3063 | 1323 | 1323.0 | 50.2 | 50.2 | Inhibition and facilitation of nucleic acid amplification. | I G Wilson | Appl Environ Microbiol | 1997 | 9327537 | No |
| 3064 | 1323 | 1323.0 | 59.6 | 59.6 | A decade of immune-checkpoint inhibitors in cancer therapy. | Caroline Robert | Nat Commun | 2020 | 32732879 | Yes |
| 3065 | 10580 | 1322.5 | 365.6 | 45.7 | Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. | V J Felitti, R F Anda, D Nordenberg, D F Williamson, A M Spitz, V Edwards, M P Koss, J S Marks | Am J Prev Med | 1998 | 9635069 | Yes |
| 3066 | 1322 | 1322.0 | 25.4 | 25.4 | Antigen-specific interaction between T and B cells. | A Lanzavecchia | Nature | 1985 | 3157869 | Yes |
| 3067 | 1322 | 1322.0 | 0.0 | 0.0 | Measurement of feelings using visual analogue scales. | R C Aitken | Proc R Soc Med | 1969 | 4899510 | No |
| 3068 | 2644 | 1322.0 | 49.3 | 24.6 | Live or let die: the cell's response to p53. | Karen H Vousden, Xin Lu | Nat Rev Cancer | 2002 | 12154352 | No |
| 3069 | 3965 | 1321.7 | 196.3 | 65.4 | In search of how people change. Applications to addictive behaviors. | J O Prochaska, C C DiClemente, J C Norcross | Am Psychol | 1992 | 1329589 | Yes |
| 3070 | 1321 | 1321.0 | 41.5 | 41.5 | Peritonectomy procedures. | P H Sugarbaker | Ann Surg | 1995 | 7826158 | Yes |
| 3071 | 1321 | 1321.0 | 35.0 | 35.0 | AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. | D Grahame Hardie | Genes Dev | 2011 | 21937710 | No |
| 3072 | 1321 | 1321.0 | 46.6 | 46.6 | Human milk oligosaccharides: every baby needs a sugar mama. | Lars Bode | Glycobiology | 2012 | 22513036 | No |
| 3073 | 2641 | 1320.5 | 56.3 | 28.1 | Protein aggregation and neurodegenerative disease. | Christopher A Ross, Michelle A Poirier | Nat Med | 2004 | 15272267 | No |
| 3074 | 1320 | 1320.0 | 36.2 | 36.2 | Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. | U Mitzdorf | Physiol Rev | 1985 | 3880898 | No |
| 3075 | 1320 | 1320.0 | 0.0 | 0.0 | Autistic disturbances of affective contact. | L Kanner | Acta Paedopsychiatr | 1968 | 4880460 | Yes |
| 3076 | 1320 | 1320.0 | 29.3 | 29.3 | Molecular physiology of low-voltage-activated t-type calcium channels. | Edward Perez-Reyes | Physiol Rev | 2003 | 12506128 | No |
| 3077 | 1320 | 1320.0 | 27.7 | 27.7 | Microsatellites: simple sequences with complex evolution. | Hans Ellegren | Nat Rev Genet | 2004 | 15153996 | No |
| 3078 | 1320 | 1320.0 | 33.5 | 33.5 | Identifying and characterizing binding sites and assessing druggability. | Thomas A Halgren | J Chem Inf Model | 2009 | 19434839 | Yes |
| 3079 | 1320 | 1320.0 | 37.1 | 37.1 | Serine, glycine and one-carbon units: cancer metabolism in full circle. | Jason W Locasale | Nat Rev Cancer | 2013 | 23822983 | No |
| 3080 | 2640 | 1320.0 | 102.1 | 51.0 | Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. | Jerome Galon, Daniela Bruni | Nat Rev Drug Discov | 2019 | 30610226 | No |
| 3081 | 3958 | 1319.3 | 111.9 | 37.3 | Molecular characterization of a peripheral receptor for cannabinoids. | S Munro, K L Thomas, M Abu-Shaar | Nature | 1993 | 7689702 | Yes |
| 3082 | 1319 | 1319.0 | 35.9 | 35.9 | Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. | Earl S Ford | Diabetes Care | 2005 | 15983333 | No |
| 3083 | 1319 | 1319.0 | 46.3 | 46.3 | Volumetric modulated arc therapy: IMRT in a single gantry arc. | Karl Otto | Med Phys | 2008 | 18293586 | Yes |
| 3084 | 2637 | 1318.5 | 0.0 | 0.0 | Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. | H A Edmondson, P E Steiner | Cancer | 1954 | 13160935 | Yes |
| 3085 | 1318 | 1318.0 | 54.5 | 54.5 | A simple method for determination of serum catalase activity and revision of reference range. | L Goth | Clin Chim Acta | 1991 | 2029780 | Yes |
| 3086 | 1318 | 1318.0 | 31.2 | 31.2 | Refined structure of the nicotinic acetylcholine receptor at 4A resolution. | Nigel Unwin | J Mol Biol | 2005 | 15701510 | Yes |
| 3087 | 2634 | 1317.0 | 43.4 | 21.7 | Genetic transformation of Drosophila with transposable element vectors. | G M Rubin, A C Spradling | Science | 1982 | 6289436 | Yes |
| 3088 | 1317 | 1317.0 | 34.2 | 34.2 | Rapid evolution of a protein in vitro by DNA shuffling. | W P Stemmer | Nature | 1994 | 8047147 | Yes |
| 3089 | 1317 | 1317.0 | 32.9 | 32.9 | Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. | P Kuzmic | Anal Biochem | 1996 | 8660575 | Yes |
| 3090 | 1317 | 1317.0 | 36.2 | 36.2 | The lipocalin protein family: structure and function. | D R Flower | Biochem J | 1996 | 8761444 | No |
| 3091 | 1317 | 1317.0 | 60.8 | 60.8 | The anatomy of stages of change. | A Bandura | Am J Health Promot | 1997 | 10170438 | No |
| 3092 | 1317 | 1317.0 | 27.1 | 27.1 | Protein tyrosine phosphatases: from genes, to function, to disease. | Nicholas K Tonks | Nat Rev Mol Cell Biol | 2006 | 17057753 | No |
| 3093 | 1317 | 1317.0 | 37.5 | 37.5 | Phosphoinositides: tiny lipids with giant impact on cell regulation. | Tamas Balla | Physiol Rev | 2013 | 23899561 | No |
| 3094 | 2633 | 1316.5 | 82.9 | 41.5 | An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. | Sun Ho Kim, Jin Mo Chung | Pain | 1992 | 1333581 | Yes |
| 3095 | 1316 | 1316.0 | 33.1 | 33.1 | Bee and wasp venoms. | E Habermann | Science | 1972 | 4113805 | No |
| 3096 | 1316 | 1316.0 | 35.9 | 35.9 | The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. | R G Gerrity | Am J Pathol | 1981 | 7234961 | Yes |
| 3097 | 1316 | 1316.0 | 32.3 | 32.3 | Apoptosis in cancer therapy: crossing the threshold. | D E Fisher | Cell | 1994 | 8069905 | No |
| 3098 | 1316 | 1316.0 | 32.3 | 32.3 | Papillomavirus infections--a major cause of human cancers. | H Zur Hausen | Biochim Biophys Acta | 1996 | 8876633 | No |
| 3099 | 2632 | 1316.0 | 68.5 | 34.2 | The free radical theory of aging matures. | K B Beckman, B N Ames | Physiol Rev | 1998 | 9562038 | No |
| 3100 | 1316 | 1316.0 | 39.3 | 39.3 | Philosophical conceptions of the self: implications for cognitive science. | Shaun Gallagher | Trends Cogn Sci | 2000 | 10637618 | Yes |
| 3101 | 2632 | 1316.0 | 47.5 | 23.8 | Stats: transcriptional control and biological impact. | David E Levy, J E Darnell | Nat Rev Mol Cell Biol | 2002 | 12209125 | No |
| 3102 | 1316 | 1316.0 | 33.4 | 33.4 | Ovarian cancer development and metastasis. | Ernst Lengyel | Am J Pathol | 2010 | 20651229 | Yes |
| 3103 | 2632 | 1316.0 | 75.4 | 37.7 | Regulation of type I interferon responses. | Lionel B Ivashkiv, Laura T Donlin | Nat Rev Immunol | 2014 | 24362405 | No |
| 3104 | 2631 | 1315.5 | 70.6 | 35.3 | Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. | Patrick S Ward, Craig B Thompson | Cancer Cell | 2012 | 22439925 | No |
| 3105 | 2630 | 1315.0 | 52.5 | 26.2 | CpG islands in vertebrate genomes. | M Gardiner-Garden, M Frommer | J Mol Biol | 1987 | 3656447 | Yes |
| 3106 | 11827 | 1314.1 | 304.6 | 33.8 | Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. | Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J Van Baren, Steven L Salzberg, Barbara J Wold, Lior Pachter | Nat Biotechnol | 2010 | 20436464 | Yes |
| 3107 | 1314 | 1314.0 | 47.1 | 47.1 | Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. | A J Alpert | J Chromatogr | 1990 | 2324207 | Yes |
| 3108 | 1314 | 1314.0 | 35.3 | 35.3 | Phylogenies from molecular sequences: inference and reliability. | J Felsenstein | Annu Rev Genet | 1988 | 3071258 | No |
| 3109 | 2628 | 1314.0 | 66.1 | 33.0 | Multipoint quantitative-trait linkage analysis in general pedigrees. | L Almasy, J Blangero | Am J Hum Genet | 1998 | 9545414 | Yes |
| 3110 | 2628 | 1314.0 | 94.7 | 47.4 | Antiseptics and disinfectants: activity, action, and resistance. | G McDonnell, A D Russell | Clin Microbiol Rev | 1999 | 9880479 | No |
| 3111 | 1314 | 1314.0 | 26.8 | 26.8 | Basement membranes: structure, assembly and role in tumour angiogenesis. | Raghu Kalluri | Nat Rev Cancer | 2003 | 12778132 | No |
| 3112 | 2628 | 1314.0 | 74.7 | 37.4 | Increasing incidence of thyroid cancer in the United States, 1973-2002. | Louise Davies, H Gilbert Welch | JAMA | 2006 | 16684987 | Yes |
| 3113 | 1314 | 1314.0 | 36.6 | 36.6 | Thermo- and pH-responsive polymers in drug delivery. | Dirk Schmaljohann | Adv Drug Deliv Rev | 2006 | 17125884 | No |
| 3114 | 2627 | 1313.5 | 123.1 | 61.5 | Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. | G Atkinson, A M Nevill | Sports Med | 1998 | 9820922 | No |
| 3115 | 2627 | 1313.5 | 61.0 | 30.5 | Mitochondrial control of cell death. | G Kroemer, J C Reed | Nat Med | 2000 | 10802706 | No |
| 3116 | 2627 | 1313.5 | 73.9 | 37.0 | Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. | Marie Cargnello, Philippe P Roux | Microbiol Mol Biol Rev | 2011 | 21372320 | No |
| 3117 | 14445 | 1313.2 | 282.8 | 25.7 | Model-based analysis of ChIP-Seq (MACS). | Yong Zhang, Tao Liu, Clifford A Meyer, Jerome Eeckhoute, David S Johnson, Bradley E Bernstein, Chad Nusbaum, Richard M Myers, Myles Brown, Wei Li, X Shirley Liu | Genome Biol | 2008 | 18798982 | Yes |
| 3118 | 1313 | 1313.0 | 38.6 | 38.6 | Experience from a multicentre stroke register: a preliminary report. | S Hatano | Bull World Health Organ | 1976 | 1088404 | Yes |
| 3119 | 2625 | 1312.5 | 66.0 | 33.0 | Endometriosis. | Linda C Giudice, Lee C Kao | Lancet | 2004 | 15541453 | No |
| 3120 | 1312 | 1312.0 | 39.4 | 39.4 | The matrix-degrading metalloproteinases. | L M Matrisian | Bioessays | 1992 | 1445287 | No |
| 3121 | 1312 | 1312.0 | 29.0 | 29.0 | Double identity for proteins of the Bcl-2 family. | J C Reed | Nature | 1997 | 9194558 | No |
| 3122 | 1312 | 1312.0 | 33.4 | 33.4 | Somatostatin and its receptor family. | Y C Patel | Front Neuroendocrinol | 1999 | 10433861 | No |
| 3123 | 1312 | 1312.0 | 27.9 | 27.9 | The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequences. | P Stothard | Biotechniques | 2000 | 10868275 | Yes |
| 3124 | 1312 | 1312.0 | 30.0 | 30.0 | Serine protease mechanism and specificity. | Lizbeth Hedstrom | Chem Rev | 2002 | 12475199 | No |
| 3125 | 1312 | 1312.0 | 28.3 | 28.3 | The roles of intracellular protein-degradation pathways in neurodegeneration. | David C Rubinsztein | Nature | 2006 | 17051204 | No |
| 3126 | 1312 | 1312.0 | 49.6 | 49.6 | Indirect and mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool. | Georgia Salanti | Res Synth Methods | 2012 | 26062083 | Yes |
| 3127 | 2623 | 1311.5 | 73.9 | 37.0 | A neurotrophic model for stress-related mood disorders. | Ronald S Duman, Lisa M Monteggia | Biol Psychiatry | 2006 | 16631126 | No |
| 3128 | 3934 | 1311.3 | 86.8 | 28.9 | A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. | R Medzhitov, P Preston-Hurlburt, C A Janeway | Nature | 1997 | 9237759 | Yes |
| 3129 | 1311 | 1311.0 | 22.9 | 22.9 | Clonal selection and learning in the antibody system. | K Rajewsky | Nature | 1996 | 8657279 | No |
| 3130 | 3933 | 1311.0 | 103.2 | 34.4 | Thresholding of statistical maps in functional neuroimaging using the false discovery rate. | Christopher R Genovese, Nicole A Lazar, Thomas Nichols | Neuroimage | 2002 | 11906227 | Yes |
| 3131 | 7863 | 1310.5 | 299.7 | 49.9 | GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. | Zefang Tang, Chenwei Li, Boxi Kang, Ge Gao, Cheng Li, Zemin Zhang | Nucleic Acids Res | 2017 | 28407145 | Yes |
| 3132 | 1310 | 1310.0 | 0.0 | 0.0 | Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. | P F Scholander | J Biol Chem | 1947 | 20281644 | Yes |
| 3133 | 2619 | 1309.5 | 0.0 | 0.0 | Immunization of dissociated spleen cell cultures from normal mice. | R I Mishell, R W Dutton | J Exp Med | 1967 | 6034749 | Yes |
| 3134 | 2618 | 1309.0 | 61.1 | 30.6 | Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. | E Y Chen, P H Seeburg | DNA | 1985 | 3996185 | Yes |
| 3135 | 2618 | 1309.0 | 54.6 | 27.3 | The molecular biology of axon guidance. | M Tessier-Lavigne, C S Goodman | Science | 1996 | 8895455 | No |
| 3136 | 1309 | 1309.0 | 35.6 | 35.6 | Disorders of iron metabolism. | N C Andrews | N Engl J Med | 1999 | 10607817 | No |
| 3137 | 2618 | 1309.0 | 64.2 | 32.1 | Regulation of wound healing by growth factors and cytokines. | Sabine Werner, Richard Grose | Physiol Rev | 2003 | 12843410 | No |
| 3138 | 1309 | 1309.0 | 31.6 | 31.6 | Oxidative stress in neurodegeneration: cause or consequence? | Julie K Andersen | Nat Med | 2004 | 15298006 | No |
| 3139 | 2618 | 1309.0 | 55.1 | 27.6 | Regulation of translation initiation in eukaryotes: mechanisms and biological targets. | Nahum Sonenberg, Alan G Hinnebusch | Cell | 2009 | 19239892 | No |
| 3140 | 9161 | 1308.7 | 261.0 | 37.3 | Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. | , Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur Wheeler | N Engl J Med | 2000 | 10793162 | Yes |
| 3141 | 1308 | 1308.0 | 35.4 | 35.4 | Drug delivery and targeting. | R Langer | Nature | 1998 | 9579855 | No |
| 3142 | 1308 | 1308.0 | 25.0 | 25.0 | NK cell receptors. | L L Lanier | Annu Rev Immunol | 1998 | 9597134 | No |
| 3143 | 1308 | 1308.0 | 37.8 | 37.8 | A theory of magnitude: common cortical metrics of time, space and quantity. | Vincent Walsh | Trends Cogn Sci | 2003 | 14585444 | Yes |
| 3144 | 1308 | 1308.0 | 40.6 | 40.6 | Pectin structure and biosynthesis. | Debra Mohnen | Curr Opin Plant Biol | 2008 | 18486536 | No |
| 3145 | 1307 | 1307.0 | 62.4 | 62.4 | A cognitive approach to panic. | D M Clark | Behav Res Ther | 1986 | 3741311 | Yes |
| 3146 | 1307 | 1307.0 | 43.3 | 43.3 | The somatic marker hypothesis and the possible functions of the prefrontal cortex. | A R Damasio | Philos Trans R Soc Lond B Biol Sci | 1996 | 8941953 | No |
| 3147 | 1307 | 1307.0 | 28.9 | 28.9 | Epstein-Barr virus infection. | J I Cohen | N Engl J Med | 2000 | 10944566 | No |
| 3148 | 1307 | 1307.0 | 47.9 | 47.9 | Type 2 inflammation in asthma--present in most, absent in many. | John V Fahy | Nat Rev Immunol | 2015 | 25534623 | No |
| 3149 | 1306 | 1306.0 | 29.8 | 29.8 | Chemistry and biology of the immunophilins and their immunosuppressive ligands. | S L Schreiber | Science | 1991 | 1702904 | No |
| 3150 | 1306 | 1306.0 | 42.1 | 42.1 | Varieties of impulsivity. | J L Evenden | Psychopharmacology (Berl) | 1999 | 10550486 | No |
| 3151 | 1306 | 1306.0 | 0.0 | 0.0 | Agammaglobulinemia. | O C Bruton | Pediatrics | 1952 | 14929630 | Yes |
| 3152 | 2611 | 1305.5 | 51.4 | 25.7 | Gene silencing in cancer in association with promoter hypermethylation. | James G Herman, Stephen B Baylin | N Engl J Med | 2003 | 14627790 | No |
| 3153 | 1305 | 1305.0 | 0.0 | 0.0 | Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. | W W Douglas | Br J Pharmacol | 1968 | 4882190 | No |
| 3154 | 1305 | 1305.0 | 0.0 | 0.0 | A quantitative immunochemical measure of the primary interaction between I BSA and antibody. | R S Farr | J Infect Dis | 1958 | 13611294 | Yes |
| 3155 | 1304 | 1304.0 | 26.0 | 26.0 | Up on the tightrope: natural killer cell activation and inhibition. | Lewis L Lanier | Nat Immunol | 2008 | 18425106 | No |
| 3156 | 2608 | 1304.0 | 56.9 | 28.4 | Blinded by the Light: The Growing Complexity of p53. | Karen H Vousden, Carol Prives | Cell | 2009 | 19410540 | No |
| 3157 | 2607 | 1303.5 | 66.0 | 33.0 | Epidermal growth factor. | G Carpenter, S Cohen | Annu Rev Biochem | 1979 | 382984 | No |
| 3158 | 2607 | 1303.5 | 51.3 | 25.6 | Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. | C W Greider, E H Blackburn | Cell | 1985 | 3907856 | Yes |
| 3159 | 1303 | 1303.0 | 32.9 | 32.9 | A tension-based theory of morphogenesis and compact wiring in the central nervous system. | D C Van Essen | Nature | 1997 | 9002514 | Yes |
| 3160 | 1303 | 1303.0 | 30.4 | 30.4 | S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. | R Donato | Int J Biochem Cell Biol | 2001 | 11390274 | No |
| 3161 | 1303 | 1303.0 | 52.2 | 52.2 | Bisphenol A and human health: a review of the literature. | Johanna R Rochester | Reprod Toxicol | 2013 | 23994667 | No |
| 3162 | 3907 | 1302.3 | 195.9 | 65.3 | Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. | Yan Zheng, Sylvia H Ley, Frank B Hu | Nat Rev Endocrinol | 2018 | 29219149 | No |
| 3163 | 2604 | 1302.0 | 80.0 | 40.0 | A simple index of Crohn's-disease activity. | R F Harvey, J M Bradshaw | Lancet | 1980 | 6102236 | Yes |
| 3164 | 3906 | 1302.0 | 99.5 | 33.2 | Methods in mammalian autophagy research. | Noboru Mizushima, Tamotsu Yoshimori, Beth Levine | Cell | 2010 | 20144757 | Yes |
| 3165 | 3905 | 1301.7 | 99.8 | 33.3 | Global and societal implications of the diabetes epidemic. | P Zimmet, K G Alberti, J Shaw | Nature | 2001 | 11742409 | No |
| 3166 | 2603 | 1301.5 | 188.3 | 94.2 | TYGS is an automated high-throughput platform for state-of-the-art genome-based taxonomy. | Jan P Meier-Kolthoff, Markus Goker | Nat Commun | 2019 | 31097708 | Yes |
| 3167 | 2602 | 1301.0 | 66.0 | 33.0 | Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. | A Warshel, M Levitt | J Mol Biol | 1976 | 985660 | Yes |
| 3168 | 2602 | 1301.0 | 50.1 | 25.1 | The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. | T Maehama, J E Dixon | J Biol Chem | 1998 | 9593664 | Yes |
| 3169 | 1301 | 1301.0 | 24.3 | 24.3 | Biological robustness. | Hiroaki Kitano | Nat Rev Genet | 2004 | 15520792 | No |
| 3170 | 2601 | 1300.5 | 76.2 | 38.1 | Accurate molecular van der Waals interactions from ground-state electron density and free-atom reference data. | Alexandre Tkatchenko, Matthias Scheffler | Phys Rev Lett | 2009 | 19257665 | Yes |
| 3171 | 1300 | 1300.0 | 32.6 | 32.6 | Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. | J Deisenhofer | Biochemistry | 1981 | 7236608 | Yes |
| 3172 | 2600 | 1300.0 | 47.2 | 23.6 | The DNA damage response: putting checkpoints in perspective. | B B Zhou, S J Elledge | Nature | 2000 | 11100718 | No |
| 3173 | 1300 | 1300.0 | 30.8 | 30.8 | Production of recombinant protein therapeutics in cultivated mammalian cells. | Florian M Wurm | Nat Biotechnol | 2004 | 15529164 | No |
| 3174 | 1300 | 1300.0 | 45.1 | 45.1 | DREADDs for Neuroscientists. | Bryan L Roth | Neuron | 2016 | 26889809 | No |
| 3175 | 5197 | 1299.2 | 116.5 | 29.1 | Interleukin-10 and the interleukin-10 receptor. | K W Moore, R De Waal Malefyt, R L Coffman, A O'Garra | Annu Rev Immunol | 2001 | 11244051 | No |
| 3176 | 1299 | 1299.0 | 33.5 | 33.5 | Context and behavioral processes in extinction. | Mark E Bouton | Learn Mem | 2004 | 15466298 | No |
| 3177 | 2598 | 1299.0 | 64.7 | 32.4 | Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations. | In Suk Joung, Thomas E Cheatham | J Phys Chem B | 2008 | 18593145 | Yes |
| 3178 | 1299 | 1299.0 | 33.4 | 33.4 | An introduction to data reduction: space-group determination, scaling and intensity statistics. | Philip R Evans | Acta Crystallogr D Biol Crystallogr | 2011 | 21460446 | Yes |
| 3179 | 3895 | 1298.3 | 99.0 | 33.0 | Mechanisms linking obesity to insulin resistance and type 2 diabetes. | Steven E Kahn, Rebecca L Hull, Kristina M Utzschneider | Nature | 2006 | 17167471 | No |
| 3180 | 2596 | 1298.0 | 54.9 | 27.4 | NF-kappaB: linking inflammation and immunity to cancer development and progression. | Michael Karin, Florian R Greten | Nat Rev Immunol | 2005 | 16175180 | No |
| 3181 | 1298 | 1298.0 | 36.6 | 36.6 | Neurophysiological and computational principles of cortical rhythms in cognition. | Xiao-Jing Wang | Physiol Rev | 2010 | 20664082 | No |
| 3182 | 2595 | 1297.5 | 167.9 | 84.0 | The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. | Hussin A Rothan, Siddappa N Byrareddy | J Autoimmun | 2020 | 32113704 | No |
| 3183 | 7783 | 1297.2 | 183.3 | 30.6 | Enzymatic assembly of DNA molecules up to several hundred kilobases. | Daniel G Gibson, Lei Young, Ray-Yuan Chuang, J Craig Venter, Clyde A Hutchison, Hamilton O Smith | Nat Methods | 2009 | 19363495 | Yes |
| 3184 | 1297 | 1297.0 | 32.2 | 32.2 | Receptors for epidermal growth factor and other polypeptide mitogens. | G Carpenter | Annu Rev Biochem | 1987 | 3039909 | No |
| 3185 | 2594 | 1297.0 | 107.7 | 53.9 | The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. | R Naatanen, T Picton | Psychophysiology | 1987 | 3615753 | Yes |
| 3186 | 1297 | 1297.0 | 41.1 | 41.1 | Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. | J H Luft | Anat Rec | 1971 | 4108333 | Yes |
| 3187 | 3891 | 1297.0 | 151.4 | 50.5 | The biology and management of non-small cell lung cancer. | Roy S Herbst, Daniel Morgensztern, Chris Boshoff | Nature | 2018 | 29364287 | No |
| 3188 | 1296 | 1296.0 | 37.3 | 37.3 | Epidemiology of women and depression. | Ronald C Kessler | J Affect Disord | 2003 | 12646294 | Yes |
| 3189 | 1295 | 1295.0 | 37.0 | 37.0 | Neural systems for recognizing emotion. | Ralph Adolphs | Curr Opin Neurobiol | 2002 | 12015233 | No |
| 3190 | 1295 | 1295.0 | 31.8 | 31.8 | ImageJ for microscopy. | Tony J Collins | Biotechniques | 2007 | 17936939 | No |
| 3191 | 2589 | 1294.5 | 54.2 | 27.1 | Sequence logos: a new way to display consensus sequences. | T D Schneider, R M Stephens | Nucleic Acids Res | 1990 | 2172928 | Yes |
| 3192 | 1294 | 1294.0 | 51.1 | 51.1 | The P300 wave of the human event-related potential. | T W Picton | J Clin Neurophysiol | 1992 | 1464675 | No |
| 3193 | 1294 | 1294.0 | 20.9 | 20.9 | A restriction point for control of normal animal cell proliferation. | A B Pardee | Proc Natl Acad Sci U S A | 1974 | 4524638 | Yes |
| 3194 | 1293 | 1293.0 | 25.6 | 25.6 | Evolution of ageing. | T B Kirkwood | Nature | 1977 | 593350 | Yes |
| 3195 | 1293 | 1293.0 | 0.0 | 0.0 | Electrophoretic separation of plasma lipoproteins in agarose gel. | R P Noble | J Lipid Res | 1968 | 4176473 | Yes |
| 3196 | 1293 | 1293.0 | 36.3 | 36.3 | Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. | Paul Willner | Neuropsychobiology | 2005 | 16037678 | No |
| 3197 | 2585 | 1292.5 | 51.4 | 25.7 | Dynamic instability of microtubule growth. | T Mitchison, M Kirschner | Nature | 1984 | 6504138 | Yes |
| 3198 | 1292 | 1292.0 | 24.3 | 24.3 | CD95's deadly mission in the immune system. | P H Krammer | Nature | 2000 | 11048730 | No |
| 3199 | 1292 | 1292.0 | 33.2 | 33.2 | Reactive oxygen radicals in signaling and damage in the ischemic brain. | P H Chan | J Cereb Blood Flow Metab | 2001 | 11149664 | No |
| 3200 | 1292 | 1292.0 | 42.5 | 42.5 | Socioeconomic status and obesity. | Lindsay McLaren | Epidemiol Rev | 2007 | 17478442 | No |
| 3201 | 2583 | 1291.5 | 76.7 | 38.4 | Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. | Xiaobo Chen, Samuel S Mao | Chem Rev | 2007 | 17590053 | Yes |
| 3202 | 1291 | 1291.0 | 30.4 | 30.4 | Viruses in the sea. | Curtis A Suttle | Nature | 2005 | 16163346 | No |
| 3203 | 9036 | 1290.9 | 603.5 | 86.2 | TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data. | Chengjie Chen, Hao Chen, Yi Zhang, Hannah R Thomas, Margaret H Frank, Yehua He, Rui Xia | Mol Plant | 2020 | 32585190 | Yes |
| 3204 | 6453 | 1290.6 | 201.3 | 40.3 | Biodiversity hotspots for conservation priorities. | N Myers, R A Mittermeier, C G Mittermeier, G A Da Fonseca, J Kent | Nature | 2000 | 10706275 | Yes |
| 3205 | 1290 | 1290.0 | 37.7 | 37.7 | Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies. | Masabumi Shibuya | Genes Cancer | 2011 | 22866201 | Yes |
| 3206 | 7735 | 1289.2 | 180.4 | 30.1 | Principal components analysis corrects for stratification in genome-wide association studies. | Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich | Nat Genet | 2006 | 16862161 | Yes |
| 3207 | 1289 | 1289.0 | 43.9 | 43.9 | Agents that increase the permeability of the outer membrane. | M Vaara | Microbiol Rev | 1992 | 1406489 | No |
| 3208 | 1289 | 1289.0 | 39.8 | 39.8 | Analyzing the mosaic structure of genes. | J M Smith | J Mol Evol | 1992 | 1556748 | No |
| 3209 | 1289 | 1289.0 | 40.8 | 40.8 | Somatostatin. | S Reichlin | N Engl J Med | 1983 | 6139753 | No |
| 3210 | 1289 | 1289.0 | 62.9 | 62.9 | Coping theory and research: past, present, and future. | R S Lazarus | Psychosom Med | 1993 | 8346332 | No |
| 3211 | 1289 | 1289.0 | 30.7 | 30.7 | Brain tumors. | L M DeAngelis | N Engl J Med | 2001 | 11150363 | No |
| 3212 | 1289 | 1289.0 | 29.4 | 29.4 | Microglia as a source and target of cytokines. | Uwe-Karsten Hanisch | Glia | 2002 | 12379902 | No |
| 3213 | 1289 | 1289.0 | 33.9 | 33.9 | Bile acids: regulation of synthesis. | John Y L Chiang | J Lipid Res | 2009 | 19346330 | No |
| 3214 | 1289 | 1289.0 | 36.6 | 36.6 | ERK1/2 MAP kinases: structure, function, and regulation. | Robert Roskoski | Pharmacol Res | 2012 | 22569528 | No |
| 3215 | 1289 | 1289.0 | 60.1 | 60.1 | The expanding regulatory mechanisms and cellular functions of circular RNAs. | Ling-Ling Chen | Nat Rev Mol Cell Biol | 2020 | 32366901 | No |
| 3216 | 2576 | 1288.0 | 71.0 | 35.5 | Regulatory sequences involved in the promotion and termination of RNA transcription. | M Rosenberg, D Court | Annu Rev Genet | 1979 | 94251 | No |
| 3217 | 1287 | 1287.0 | 0.0 | 0.0 | Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. | A Boyum | Scand J Clin Lab Invest Suppl | 1968 | 4179066 | Yes |
| 3218 | 2574 | 1287.0 | 101.8 | 50.9 | The Human Intestinal Microbiome in Health and Disease. | Susan V Lynch, Oluf Pedersen | N Engl J Med | 2016 | 27974040 | No |
| 3219 | 2573 | 1286.5 | 87.6 | 43.8 | Atomic structure and chemistry of human serum albumin. | X M He, D C Carter | Nature | 1992 | 1630489 | Yes |
| 3220 | 2573 | 1286.5 | 63.1 | 31.6 | Production of single-stranded plasmid DNA. | J Vieira, J Messing | Methods Enzymol | 1987 | 3323803 | Yes |
| 3221 | 2573 | 1286.5 | 0.0 | 0.0 | Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. | G J Todaro, H Green | J Cell Biol | 1963 | 13985244 | Yes |
| 3222 | 5145 | 1286.2 | 123.0 | 30.8 | Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. | G L Wang, B H Jiang, E A Rue, G L Semenza | Proc Natl Acad Sci U S A | 1995 | 7539918 | Yes |
| 3223 | 1286 | 1286.0 | 39.9 | 39.9 | Diversity and ubiquity of K channels. | B Rudy | Neuroscience | 1988 | 2457185 | No |
| 3224 | 1285 | 1285.0 | 49.2 | 49.2 | Freezing of living cells: mechanisms and implications. | P Mazur | Am J Physiol | 1984 | 6383068 | No |
| 3225 | 2570 | 1285.0 | 63.0 | 31.5 | ZINC--a free database of commercially available compounds for virtual screening. | John J Irwin, Brian K Shoichet | J Chem Inf Model | 2005 | 15667143 | Yes |
| 3226 | 2568 | 1284.0 | 48.8 | 24.4 | Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. | M Fried, D M Crothers | Nucleic Acids Res | 1981 | 6275366 | Yes |
| 3227 | 2568 | 1284.0 | 97.8 | 48.9 | Gut microbiota, metabolites and host immunity. | Michelle G Rooks, Wendy S Garrett | Nat Rev Immunol | 2016 | 27231050 | No |
| 3228 | 3851 | 1283.7 | 83.6 | 27.9 | 5-fluorouracil: mechanisms of action and clinical strategies. | Daniel B Longley, D Paul Harkin, Patrick G Johnston | Nat Rev Cancer | 2003 | 12724731 | No |
| 3229 | 12830 | 1283.0 | 438.7 | 43.9 | The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. | N K Aaronson, S Ahmedzai, B Bergman, M Bullinger, A Cull, N J Duez, A Filiberti, H Flechtner, S B Fleishman, J C De Haes | J Natl Cancer Inst | 1993 | 8433390 | Yes |
| 3230 | 6415 | 1283.0 | 221.7 | 44.3 | A simulation study of the number of events per variable in logistic regression analysis. | P Peduzzi, J Concato, E Kemper, T R Holford, A R Feinstein | J Clin Epidemiol | 1996 | 8970487 | Yes |
| 3231 | 1283 | 1283.0 | 33.7 | 33.7 | Metabolism and functions of glutathione in brain. | R Dringen | Prog Neurobiol | 2000 | 10880854 | No |
| 3232 | 1283 | 1283.0 | 0.0 | 0.0 | The effective period of preventive antibiotic action in experimental incisions and dermal lesions. | J F Burke | Surgery | 1961 | 16722001 | Yes |
| 3233 | 1283 | 1283.0 | 27.5 | 27.5 | Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. | Michael Forgac | Nat Rev Mol Cell Biol | 2007 | 17912264 | No |
| 3234 | 5131 | 1282.8 | 151.6 | 37.9 | Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. | N Weidner, J P Semple, W R Welch, J Folkman | N Engl J Med | 1991 | 1701519 | Yes |
| 3235 | 2564 | 1282.0 | 55.2 | 27.6 | Establishment and characterization of a human histiocytic lymphoma cell line (U-937). | C Sundstrom, K Nilsson | Int J Cancer | 1976 | 178611 | Yes |
| 3236 | 1282 | 1282.0 | 36.4 | 36.4 | Normalization of cell responses in cat striate cortex. | D J Heeger | Vis Neurosci | 1992 | 1504027 | Yes |
| 3237 | 1282 | 1282.0 | 0.0 | 0.0 | The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. | G A Rose | Bull World Health Organ | 1962 | 13974778 | Yes |
| 3238 | 1282 | 1282.0 | 45.5 | 45.5 | Platelet-rich plasma: evidence to support its use. | Robert E Marx | J Oral Maxillofac Surg | 2004 | 15085519 | No |
| 3239 | 2564 | 1282.0 | 114.5 | 57.2 | Network analysis: an integrative approach to the structure of psychopathology. | Denny Borsboom, Angelique O J Cramer | Annu Rev Clin Psychol | 2013 | 23537483 | No |
| 3240 | 3844 | 1281.3 | 181.7 | 60.6 | The NLRP3 inflammasome: molecular activation and regulation to therapeutics. | Karen V Swanson, Meng Deng, Jenny P Y Ting | Nat Rev Immunol | 2019 | 31036962 | No |
| 3241 | 1281 | 1281.0 | 36.8 | 36.8 | A human model of gastric carcinogenesis. | P Correa | Cancer Res | 1988 | 3288329 | No |
| 3242 | 1281 | 1281.0 | 0.0 | 0.0 | Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. | J O Holloszy | J Biol Chem | 1967 | 4290225 | Yes |
| 3243 | 1281 | 1281.0 | 32.4 | 32.4 | Formation and function of the myofibroblast during tissue repair. | Boris Hinz | J Invest Dermatol | 2007 | 17299435 | No |
| 3244 | 3843 | 1281.0 | 99.9 | 33.3 | Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. | Davis J McCarthy, Yunshun Chen, Gordon K Smyth | Nucleic Acids Res | 2012 | 22287627 | Yes |
| 3245 | 1281 | 1281.0 | 49.6 | 49.6 | The angular gyrus: multiple functions and multiple subdivisions. | Mohamed L Seghier | Neuroscientist | 2013 | 22547530 | No |
| 3246 | 3841 | 1280.3 | 120.9 | 40.3 | Oxidants, antioxidants, and the degenerative diseases of aging. | B N Ames, M K Shigenaga, T M Hagen | Proc Natl Acad Sci U S A | 1993 | 8367443 | No |
| 3247 | 1280 | 1280.0 | 0.0 | 0.0 | The antidiuretic hormone and the factors which determine its release. | E B Verney | Proc R Soc Lond B Biol Sci | 1947 | 18918876 | Yes |
| 3248 | 1280 | 1280.0 | 39.4 | 39.4 | The multiple-demand (MD) system of the primate brain: mental programs for intelligent behaviour. | John Duncan | Trends Cogn Sci | 2010 | 20171926 | No |
| 3249 | 1280 | 1280.0 | 0.0 | 0.0 | Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. | H M Kalckar | J Biol Chem | 1947 | 20285041 | Yes |
| 3250 | 3840 | 1280.0 | 142.1 | 47.4 | Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. | Michael A Postow, Robert Sidlow, Matthew D Hellmann | N Engl J Med | 2018 | 29320654 | No |
| 3251 | 5119 | 1279.8 | 147.2 | 36.8 | Toxic potential of materials at the nanolevel. | Andre Nel, Tian Xia, Lutz Madler, Ning Li | Science | 2006 | 16456071 | No |
| 3252 | 3839 | 1279.7 | 115.5 | 38.5 | SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. | Manolo Gouy, Stephane Guindon, Olivier Gascuel | Mol Biol Evol | 2010 | 19854763 | Yes |
| 3253 | 2558 | 1279.0 | 92.8 | 46.4 | Consensus methods for medical and health services research. | J Jones, D Hunter | BMJ | 1995 | 7640549 | No |
| 3254 | 1279 | 1279.0 | 23.3 | 23.3 | Regulatory T cells: key controllers of immunologic self-tolerance. | S Sakaguchi | Cell | 2000 | 10850488 | No |
| 3255 | 1279 | 1279.0 | 25.6 | 25.6 | A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. | Xuemei Chen | Science | 2004 | 12893888 | Yes |
| 3256 | 2558 | 1279.0 | 57.2 | 28.6 | Deep tissue two-photon microscopy. | Fritjof Helmchen, Winfried Denk | Nat Methods | 2005 | 16299478 | No |
| 3257 | 3835 | 1278.3 | 98.4 | 32.8 | The widespread regulation of microRNA biogenesis, function and decay. | Jacek Krol, Inga Loedige, Witold Filipowicz | Nat Rev Genet | 2010 | 20661255 | No |
| 3258 | 1278 | 1278.0 | 27.8 | 27.8 | Platelets in atherothrombosis. | Zaverio M Ruggeri | Nat Med | 2002 | 12411949 | No |
| 3259 | 2555 | 1277.5 | 78.2 | 39.1 | The memory function of sleep. | Susanne Diekelmann, Jan Born | Nat Rev Neurosci | 2010 | 20046194 | No |
| 3260 | 1277 | 1277.0 | 21.7 | 21.7 | Mitotic kinases as regulators of cell division and its checkpoints. | E A Nigg | Nat Rev Mol Cell Biol | 2001 | 11413462 | No |
| 3261 | 1277 | 1277.0 | 42.5 | 42.5 | Globalization of diabetes: the role of diet, lifestyle, and genes. | Frank B Hu | Diabetes Care | 2011 | 21617109 | No |
| 3262 | 1277 | 1277.0 | 36.6 | 36.6 | Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. | Rakesh K Jain | Cancer Cell | 2014 | 25517747 | No |
| 3263 | 2553 | 1276.5 | 67.9 | 34.0 | Nanostructures in biodiagnostics. | Nathaniel L Rosi, Chad A Mirkin | Chem Rev | 2005 | 15826019 | No |
| 3264 | 2553 | 1276.5 | 106.5 | 53.2 | Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. | T J Cole, T Lobstein | Pediatr Obes | 2012 | 22715120 | Yes |
| 3265 | 2552 | 1276.0 | 90.7 | 45.4 | A formula to estimate the approximate surface area if height and weight be known. 1916. | D Du Bois, E F Du Bois | Nutrition | 1989 | 2520314 | No |
| 3266 | 2552 | 1276.0 | 55.7 | 27.9 | A rapid, sensitive, and specific method for the determination of protein in dilute solution. | W Schaffner, C Weissmann | Anal Biochem | 1973 | 4128882 | Yes |
| 3267 | 1276 | 1276.0 | 30.2 | 30.2 | Matrix eQTL: ultra fast eQTL analysis via large matrix operations. | Andrey A Shabalin | Bioinformatics | 2012 | 22492648 | Yes |
| 3268 | 8930 | 1275.7 | 272.3 | 38.9 | Toxicity and response criteria of the Eastern Cooperative Oncology Group. | M M Oken, R H Creech, D C Tormey, J Horton, T E Davis, E T McFadden, P P Carbone | Am J Clin Oncol | 1982 | 7165009 | Yes |
| 3269 | 14031 | 1275.5 | 365.1 | 33.2 | New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. | P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T Van Oosterom, M C Christian, S G Gwyther | J Natl Cancer Inst | 2000 | 10655437 | No |
| 3270 | 3826 | 1275.3 | 102.8 | 34.3 | Regulation of cancer cell metabolism. | Rob A Cairns, Isaac S Harris, Tak W Mak | Nat Rev Cancer | 2011 | 21258394 | No |
| 3271 | 1275 | 1275.0 | 46.6 | 46.6 | Cardiovascular and renal actions of dopamine: potential clinical applications. | L I Goldberg | Pharmacol Rev | 1972 | 4554480 | No |
| 3272 | 1275 | 1275.0 | 38.8 | 38.8 | Peptide antibiotics and their role in innate immunity. | H G Boman | Annu Rev Immunol | 1995 | 7612236 | No |
| 3273 | 2550 | 1275.0 | 82.3 | 41.1 | The capacity of visual working memory for features and conjunctions. | S J Luck, E K Vogel | Nature | 1997 | 9384378 | Yes |
| 3274 | 1274 | 1274.0 | 45.4 | 45.4 | Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. | Y Kono | Arch Biochem Biophys | 1978 | 24422 | Yes |
| 3275 | 2547 | 1273.5 | 52.9 | 26.4 | Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. | J A Ledbetter, L A Herzenberg | Immunol Rev | 1979 | 398327 | No |
| 3276 | 2547 | 1273.5 | 63.7 | 31.9 | Peroxisome proliferator-activated receptors: nuclear control of metabolism. | B Desvergne, W Wahli | Endocr Rev | 1999 | 10529898 | No |
| 3277 | 2547 | 1273.5 | 83.3 | 41.6 | Toll-like receptor signaling pathways. | Takumi Kawasaki, Taro Kawai | Front Immunol | 2014 | 25309543 | No |
| 3278 | 1273 | 1273.0 | 29.9 | 29.9 | Neurons with graded response have collective computational properties like those of two-state neurons. | J J Hopfield | Proc Natl Acad Sci U S A | 1984 | 6587342 | Yes |
| 3279 | 1273 | 1273.0 | 23.5 | 23.5 | Kinesin and dynein superfamily proteins and the mechanism of organelle transport. | N Hirokawa | Science | 1998 | 9438838 | No |
| 3280 | 1273 | 1273.0 | 49.5 | 49.5 | Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? | R S Barbour | BMJ | 2001 | 11337448 | No |
| 3281 | 3819 | 1273.0 | 155.5 | 51.8 | Rheumatoid arthritis. | Josef S Smolen, Daniel Aletaha, Iain B McInnes | Lancet | 2016 | 27156434 | No |
| 3282 | 2545 | 1272.5 | 64.1 | 32.0 | The regulation of IL-10 production by immune cells. | Margarida Saraiva, Anne O'Garra | Nat Rev Immunol | 2010 | 20154735 | No |
| 3283 | 1272 | 1272.0 | 21.1 | 21.1 | Mutation selection and the natural history of cancer. | J Cairns | Nature | 1975 | 1143315 | Yes |
| 3284 | 2544 | 1272.0 | 73.4 | 36.7 | A review of central 5-HT receptors and their function. | N M Barnes, T Sharp | Neuropharmacology | 1999 | 10462127 | No |
| 3285 | 1272 | 1272.0 | 0.0 | 0.0 | Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. | P B Medawar | Br J Exp Pathol | 1948 | 18865105 | Yes |
| 3286 | 3814 | 1271.3 | 177.2 | 59.1 | Relatives of the impaired elderly: correlates of feelings of burden. | S H Zarit, K E Reever, J Bach-Peterson | Gerontologist | 1980 | 7203086 | Yes |
| 3287 | 1271 | 1271.0 | 31.1 | 31.1 | Short-term synaptic plasticity. | R S Zucker | Annu Rev Neurosci | 1989 | 2648947 | No |
| 3288 | 1271 | 1271.0 | 81.1 | 81.1 | Root canal anatomy of the human permanent teeth. | F J Vertucci | Oral Surg Oral Med Oral Pathol | 1984 | 6595621 | Yes |
| 3289 | 1271 | 1271.0 | 28.1 | 28.1 | An overview of epithelio-mesenchymal transformation. | E D Hay | Acta Anat (Basel) | 1995 | 8714286 | No |
| 3290 | 1271 | 1271.0 | 42.9 | 42.9 | Antioxidants in human health and disease. | B Halliwell | Annu Rev Nutr | 1996 | 8839918 | No |
| 3291 | 1271 | 1271.0 | 26.4 | 26.4 | Endocytosis and molecular sorting. | I Mellman | Annu Rev Cell Dev Biol | 1996 | 8970738 | No |
| 3292 | 1271 | 1271.0 | 28.8 | 28.8 | How neutrophils kill microbes. | Anthony W Segal | Annu Rev Immunol | 2005 | 15771570 | No |
| 3293 | 2541 | 1270.5 | 119.7 | 59.9 | Neurobiology of addiction: a neurocircuitry analysis. | George F Koob, Nora D Volkow | Lancet Psychiatry | 2016 | 27475769 | No |
| 3294 | 2539 | 1269.5 | 59.1 | 29.6 | Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. | D A Brown, J K Rose | Cell | 1992 | 1531449 | Yes |
| 3295 | 1269 | 1269.0 | 34.9 | 34.9 | Signaling through phosphatidylcholine breakdown. | J H Exton | J Biol Chem | 1990 | 2104616 | No |
| 3296 | 1269 | 1269.0 | 50.5 | 50.5 | A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. | S T Tiffany | Psychol Rev | 1990 | 2186423 | No |
| 3297 | 1269 | 1269.0 | 30.5 | 30.5 | Model for a quantum Hall effect without Landau levels: Condensed-matter realization of the "parity anomaly" | F D Haldane | Phys Rev Lett | 1988 | 10038961 | Yes |
| 3298 | 3807 | 1269.0 | 93.8 | 31.3 | Marginal structural models and causal inference in epidemiology. | J M Robins, M A Hernan, B Brumback | Epidemiology | 2000 | 10955408 | Yes |
| 3299 | 1269 | 1269.0 | 39.1 | 39.1 | High prevalence of vitamin D inadequacy and implications for health. | Michael F Holick | Mayo Clin Proc | 2006 | 16529140 | No |
| 3300 | 1269 | 1269.0 | 35.1 | 35.1 | MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. | Amy E Pasquinelli | Nat Rev Genet | 2012 | 22411466 | No |
| 3301 | 2537 | 1268.5 | 138.0 | 69.0 | Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. | S F Dworkin, L LeResche | J Craniomandib Disord | 1992 | 1298767 | No |
| 3302 | 2537 | 1268.5 | 75.5 | 37.8 | Plasmonics for improved photovoltaic devices. | Harry A Atwater, Albert Polman | Nat Mater | 2010 | 20168344 | Yes |
| 3303 | 6341 | 1268.2 | 234.5 | 46.9 | Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. | Jonathan D Power, Kelly A Barnes, Abraham Z Snyder, Bradley L Schlaggar, Steven E Petersen | Neuroimage | 2012 | 22019881 | Yes |
| 3304 | 2536 | 1268.0 | 76.8 | 38.4 | Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. | J I Morgan, T Curran | Annu Rev Neurosci | 1991 | 1903243 | No |
| 3305 | 1268 | 1268.0 | 35.7 | 35.7 | Tumor angiogenesis. | J Folkman | Adv Cancer Res | 1985 | 2581424 | No |
| 3306 | 1268 | 1268.0 | 42.2 | 42.2 | The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. | S Nolen-Hoeksema | J Abnorm Psychol | 2000 | 11016119 | Yes |
| 3307 | 1268 | 1268.0 | 43.6 | 43.6 | Dual-processing accounts of reasoning, judgment, and social cognition. | Jonathan S T B T Evans | Annu Rev Psychol | 2008 | 18154502 | No |
| 3308 | 6339 | 1267.8 | 122.2 | 24.4 | The protein kinase complement of the human genome. | G Manning, D B Whyte, R Martinez, T Hunter, S Sudarsanam | Science | 2002 | 12471243 | No |
| 3309 | 5070 | 1267.5 | 233.1 | 58.3 | An ecological perspective on health promotion programs. | K R McLeroy, D Bibeau, A Steckler, K Glanz | Health Educ Q | 1988 | 3068205 | No |
| 3310 | 2534 | 1267.0 | 99.3 | 49.6 | Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. | H Esterbauer, K H Cheeseman | Methods Enzymol | 1990 | 2233308 | Yes |
| 3311 | 2534 | 1267.0 | 69.4 | 34.7 | Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. | J L Weber, P E May | Am J Hum Genet | 1989 | 2916582 | Yes |
| 3312 | 1267 | 1267.0 | 48.3 | 48.3 | Substance P. | B Pernow | Pharmacol Rev | 1983 | 6196797 | No |
| 3313 | 1267 | 1267.0 | 28.8 | 28.8 | Lithium batteries and cathode materials. | M Stanley Whittingham | Chem Rev | 2004 | 15669156 | Yes |
| 3314 | 1267 | 1267.0 | 82.4 | 82.4 | Confirmatory factor analysis with ordinal data: Comparing robust maximum likelihood and diagonally weighted least squares. | Cheng-Hsien Li | Behav Res Methods | 2016 | 26174714 | Yes |
| 3315 | 1266 | 1266.0 | 63.6 | 63.6 | Self-discrepancy: a theory relating self and affect. | E T Higgins | Psychol Rev | 1987 | 3615707 | Yes |
| 3316 | 1266 | 1266.0 | 29.5 | 29.5 | Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. | H J Dargie | Lancet | 2001 | 11356434 | Yes |
| 3317 | 1266 | 1266.0 | 36.0 | 36.0 | Q-ball imaging. | David S Tuch | Magn Reson Med | 2004 | 15562495 | Yes |
| 3318 | 1266 | 1266.0 | 25.3 | 25.3 | Telomeres and human disease: ageing, cancer and beyond. | Maria A Blasco | Nat Rev Genet | 2005 | 16136653 | No |
| 3319 | 3798 | 1266.0 | 137.0 | 45.7 | Social relationships and mortality risk: a meta-analytic review. | Julianne Holt-Lunstad, Timothy B Smith, J Bradley Layton | PLoS Med | 2010 | 20668659 | No |
| 3320 | 1266 | 1266.0 | 50.7 | 50.7 | Vitamin D metabolism, mechanism of action, and clinical applications. | Daniel D Bikle | Chem Biol | 2014 | 24529992 | No |
| 3321 | 6330 | 1266.0 | 260.2 | 52.0 | MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph. | Dinghua Li, Chi-Man Liu, Ruibang Luo, Kunihiko Sadakane, Tak-Wah Lam | Bioinformatics | 2015 | 25609793 | Yes |
| 3322 | 1266 | 1266.0 | 45.2 | 45.2 | T Follicular Helper Cell Biology: A Decade of Discovery and Diseases. | Shane Crotty | Immunity | 2019 | 31117010 | No |
| 3323 | 2531 | 1265.5 | 80.4 | 40.2 | Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. | J E Hixson, D T Vernier | J Lipid Res | 1990 | 2341813 | Yes |
| 3324 | 1265 | 1265.0 | 48.7 | 48.7 | Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. | R M Post | Am J Psychiatry | 1992 | 1353322 | No |
| 3325 | 1265 | 1265.0 | 45.3 | 45.3 | The mental health continuum: from languishing to flourishing in life. | Corey L M Keyes | J Health Soc Behav | 2002 | 12096700 | Yes |
| 3326 | 1265 | 1265.0 | 32.3 | 32.3 | Optogenetics. | Karl Deisseroth | Nat Methods | 2011 | 21191368 | Yes |
| 3327 | 6325 | 1265.0 | 297.5 | 59.5 | VSEARCH: a versatile open source tool for metagenomics. | Torbjorn Rognes, Tomas Flouri, Ben Nichols, Christopher Quince, Frederic Mahe | PeerJ | 2016 | 27781170 | Yes |
| 3328 | 2529 | 1264.5 | 65.9 | 33.0 | Pharmacology and functions of metabotropic glutamate receptors. | P J Conn, J P Pin | Annu Rev Pharmacol Toxicol | 1997 | 9131252 | No |
| 3329 | 6321 | 1264.2 | 257.6 | 51.5 | KEGG: new perspectives on genomes, pathways, diseases and drugs. | Minoru Kanehisa, Miho Furumichi, Mao Tanabe, Yoko Sato, Kanae Morishima | Nucleic Acids Res | 2017 | 27899662 | Yes |
| 3330 | 1264 | 1264.0 | 30.6 | 30.6 | Lymphokine production by human T cells in disease states. | S Romagnani | Annu Rev Immunol | 1994 | 8011282 | No |
| 3331 | 1264 | 1264.0 | 28.2 | 28.2 | The myofibroblast in wound healing and fibrocontractive diseases. | G Gabbiani | J Pathol | 2003 | 12845617 | No |
| 3332 | 2528 | 1264.0 | 105.9 | 53.0 | The Tumor Microenvironment Innately Modulates Cancer Progression. | Dominique C Hinshaw, Lalita A Shevde | Cancer Res | 2019 | 31350295 | No |
| 3333 | 2527 | 1263.5 | 65.1 | 32.5 | Sulforhodamine B colorimetric assay for cytotoxicity screening. | Vanicha Vichai, Kanyawim Kirtikara | Nat Protoc | 2006 | 17406391 | Yes |
| 3334 | 2527 | 1263.5 | 127.4 | 63.7 | Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis. | Laura M Doyle, Michael Zhuo Wang | Cells | 2019 | 31311206 | No |
| 3335 | 1263 | 1263.0 | 39.3 | 39.3 | MOPAC: a semiempirical molecular orbital program. | J J Stewart | J Comput Aided Mol Des | 1990 | 2197373 | No |
| 3336 | 1263 | 1263.0 | 26.6 | 26.6 | Searching for genetic determinants in the new millennium. | N J Risch | Nature | 2000 | 10866211 | No |
| 3337 | 6312 | 1262.4 | 319.7 | 63.9 | UFBoot2: Improving the Ultrafast Bootstrap Approximation. | Diep Thi Hoang, Olga Chernomor, Arndt Von Haeseler, Bui Quang Minh, Le Sy Vinh | Mol Biol Evol | 2018 | 29077904 | Yes |
| 3338 | 1262 | 1262.0 | 28.6 | 28.6 | Nuclear factor-kappaB: the enemy within. | Bharat B Aggarwal | Cancer Cell | 2004 | 15380510 | No |
| 3339 | 1262 | 1262.0 | 22.6 | 22.6 | NFAT proteins: key regulators of T-cell development and function. | Fernando MacIan | Nat Rev Immunol | 2005 | 15928679 | No |
| 3340 | 1262 | 1262.0 | 32.4 | 32.4 | Overview of the immune response. | David D Chaplin | J Allergy Clin Immunol | 2010 | 20176265 | No |
| 3341 | 2523 | 1261.5 | 68.2 | 34.1 | Statistical tests of neutrality of mutations. | Y X Fu, W H Li | Genetics | 1993 | 8454210 | Yes |
| 3342 | 2523 | 1261.5 | 60.2 | 30.1 | The host defense of Drosophila melanogaster. | Bruno Lemaitre, Jules Hoffmann | Annu Rev Immunol | 2007 | 17201680 | No |
| 3343 | 1261 | 1261.0 | 25.6 | 25.6 | Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. | R H Schwartz | Cell | 1992 | 1335362 | No |
| 3344 | 1261 | 1261.0 | 49.9 | 49.9 | Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. | S H Safe | Crit Rev Toxicol | 1994 | 8037844 | No |
| 3345 | 1261 | 1261.0 | 37.9 | 37.9 | Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. | J C Morris | Int Psychogeriatr | 1997 | 9447441 | Yes |
| 3346 | 1261 | 1261.0 | 40.4 | 40.4 | Invasive aspergillosis. | D W Denning | Clin Infect Dis | 1998 | 9564455 | No |
| 3347 | 1261 | 1261.0 | 48.4 | 48.4 | What Good Are Positive Emotions? | Barbara L Fredrickson | Rev Gen Psychol | 1998 | 21850154 | Yes |
| 3348 | 2521 | 1260.5 | 65.3 | 32.6 | Interaction revisited: the difference between two estimates. | Douglas G Altman, J Martin Bland | BMJ | 2003 | 12543843 | No |
| 3349 | 1260 | 1260.0 | 64.4 | 64.4 | The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. | G A Ilizarov | Clin Orthop Relat Res | 1989 | 2910611 | Yes |
| 3350 | 1260 | 1260.0 | 34.9 | 34.9 | Low density lipoprotein oxidation and its pathobiological significance. | D Steinberg | J Biol Chem | 1997 | 9261091 | No |
| 3351 | 1260 | 1260.0 | 24.0 | 24.0 | Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. | Ricky W Johnstone | Nat Rev Drug Discov | 2002 | 12120280 | No |
| 3352 | 1260 | 1260.0 | 33.4 | 33.4 | Polymer conjugates as anticancer nanomedicines. | Ruth Duncan | Nat Rev Cancer | 2006 | 16900224 | No |
| 3353 | 1260 | 1260.0 | 35.1 | 35.1 | Stronger Brønsted acids. | Takahiko Akiyama | Chem Rev | 2007 | 17983247 | Yes |
| 3354 | 1260 | 1260.0 | 34.7 | 34.7 | The quantum internet. | H J Kimble | Nature | 2008 | 18563153 | Yes |
| 3355 | 1260 | 1260.0 | 31.1 | 31.1 | Ab-initio simulations of materials using VASP: Density-functional theory and beyond. | Jurgen Hafner | J Comput Chem | 2008 | 18623101 | Yes |
| 3356 | 2519 | 1259.5 | 90.7 | 45.4 | ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap. | Tauno Metsalu, Jaak Vilo | Nucleic Acids Res | 2015 | 25969447 | Yes |
| 3357 | 2518 | 1259.0 | 93.7 | 46.9 | The stunned myocardium: prolonged, postischemic ventricular dysfunction. | E Braunwald, R A Kloner | Circulation | 1982 | 6754130 | No |
| 3358 | 1259 | 1259.0 | 65.0 | 65.0 | Rating scales to assess depression in school-aged children. | M Kovacs | Acta Paedopsychiatr | 1981 | 7025571 | Yes |
| 3359 | 2518 | 1259.0 | 72.5 | 36.2 | Nitric oxide synthases: roles, tolls, and controls. | C Nathan, Q W Xie | Cell | 1994 | 7522969 | No |
| 3360 | 1259 | 1259.0 | 35.5 | 35.5 | Abiotic stress, the field environment and stress combination. | Ron Mittler | Trends Plant Sci | 2006 | 16359910 | No |
| 3361 | 1259 | 1259.0 | 32.8 | 32.8 | Physiology and pathophysiology of purinergic neurotransmission. | Geoffrey Burnstock | Physiol Rev | 2007 | 17429044 | No |
| 3362 | 1259 | 1259.0 | 57.8 | 57.8 | Using Bayes to get the most out of non-significant results. | Zoltan Dienes | Front Psychol | 2014 | 25120503 | Yes |
| 3363 | 2518 | 1259.0 | 97.4 | 48.7 | OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy. | David M Emms, Steven Kelly | Genome Biol | 2015 | 26243257 | Yes |
| 3364 | 2517 | 1258.5 | 68.7 | 34.4 | Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. | M A Pfeffer, E Braunwald | Circulation | 1990 | 2138525 | No |
| 3365 | 2516 | 1258.0 | 143.3 | 71.7 | The Neck Disability Index: a study of reliability and validity. | H Vernon, S Mior | J Manipulative Physiol Ther | 1991 | 1834753 | Yes |
| 3366 | 1258 | 1258.0 | 20.7 | 20.7 | The concept of immunological surveillance. | F M Burnet | Prog Exp Tumor Res | 1970 | 4921480 | No |
| 3367 | 1258 | 1258.0 | 26.4 | 26.4 | Signal transduction via the MAP kinases: proceed at your own RSK. | J Blenis | Proc Natl Acad Sci U S A | 1993 | 8392180 | No |
| 3368 | 1258 | 1258.0 | 33.5 | 33.5 | Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. | R Zahorec | Bratisl Lek Listy | 2001 | 11723675 | Yes |
| 3369 | 1258 | 1258.0 | 0.0 | 0.0 | A modification of receptor theory. | R P Stephenson | Br J Pharmacol Chemother | 1956 | 13383117 | Yes |
| 3370 | 1258 | 1258.0 | 37.7 | 37.7 | Periodontitis: a polymicrobial disruption of host homeostasis. | Richard P Darveau | Nat Rev Microbiol | 2010 | 20514045 | No |
| 3371 | 1258 | 1258.0 | 67.1 | 67.1 | Resin composite--state of the art. | Jack L Ferracane | Dent Mater | 2011 | 21093034 | No |
| 3372 | 1258 | 1258.0 | 48.6 | 48.6 | Odorant reception in insects: roles of receptors, binding proteins, and degrading enzymes. | Walter S Leal | Annu Rev Entomol | 2013 | 23020622 | No |
| 3373 | 2516 | 1258.0 | 85.7 | 42.9 | The gut microbiota--masters of host development and physiology. | Felix Sommer, Fredrik Backhed | Nat Rev Microbiol | 2013 | 23435359 | No |
| 3374 | 2515 | 1257.5 | 52.1 | 26.1 | Molecular chaperones in the cytosol: from nascent chain to folded protein. | F Ulrich Hartl, Manajit Hayer-Hartl | Science | 2002 | 11884745 | No |
| 3375 | 3772 | 1257.3 | 77.5 | 25.8 | SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. | Jay D Horton, Joseph L Goldstein, Michael S Brown | J Clin Invest | 2002 | 11994399 | No |
| 3376 | 2514 | 1257.0 | 100.9 | 50.5 | Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. | I B Wilson, P D Cleary | JAMA | 1995 | 7996652 | Yes |
| 3377 | 1257 | 1257.0 | 26.2 | 26.2 | SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. | S V Evans | J Mol Graph | 1993 | 8347566 | Yes |
| 3378 | 1257 | 1257.0 | 42.3 | 42.3 | The structure of common mental disorders. | R F Krueger | Arch Gen Psychiatry | 1999 | 10530634 | Yes |
| 3379 | 2513 | 1256.5 | 85.1 | 42.5 | Superoxide dismutases: I. Occurrence in higher plants. | C N Giannopolitis, S K Ries | Plant Physiol | 1977 | 16659839 | Yes |
| 3380 | 3769 | 1256.3 | 191.2 | 63.7 | Content analysis and thematic analysis: Implications for conducting a qualitative descriptive study. | Mojtaba Vaismoradi, Hannele Turunen, Terese Bondas | Nurs Health Sci | 2013 | 23480423 | No |
| 3381 | 2512 | 1256.0 | 49.5 | 24.8 | Checkpoints: controls that ensure the order of cell cycle events. | L H Hartwell, T A Weinert | Science | 1989 | 2683079 | No |
| 3382 | 1256 | 1256.0 | 40.8 | 40.8 | Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. | M E Bouton | Psychol Bull | 1993 | 8346330 | No |
| 3383 | 1256 | 1256.0 | 32.9 | 32.9 | Apoptosis. | J J Cohen | Immunol Today | 1993 | 8466628 | No |
| 3384 | 2510 | 1255.0 | 112.3 | 56.1 | Problems and proposals for recording gingivitis and plaque. | J Ainamo, I Bay | Int Dent J | 1975 | 1058834 | Yes |
| 3385 | 1255 | 1255.0 | 22.3 | 22.3 | Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. | P Rakic | J Comp Neurol | 1971 | 4101340 | Yes |
| 3386 | 1255 | 1255.0 | 40.7 | 40.7 | Strategy and tactics in protein chemistry. | B S Hartley | Biochem J | 1970 | 4923920 | No |
| 3387 | 1255 | 1255.0 | 39.1 | 39.1 | Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. | R Lotan | Biochim Biophys Acta | 1980 | 6989400 | No |
| 3388 | 1255 | 1255.0 | 39.8 | 39.8 | The Danish Cancer Registry. | Marianne Lundkjaer Gjerstorff | Scand J Public Health | 2011 | 21775350 | Yes |
| 3389 | 1255 | 1255.0 | 51.9 | 51.9 | Measures of anxiety: State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). | Laura J Julian | Arthritis Care Res (Hoboken) | 2011 | 22588767 | No |
| 3390 | 2508 | 1254.0 | 60.0 | 30.0 | DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1987 | 3474623 | Yes |
| 3391 | 2507 | 1253.5 | 75.4 | 37.7 | Mechanisms of biofilm resistance to antimicrobial agents. | T F Mah, G A O'Toole | Trends Microbiol | 2001 | 11166241 | No |
| 3392 | 2505 | 1252.5 | 86.3 | 43.1 | Long Noncoding RNAs in Cancer Pathways. | Adam M Schmitt, Howard Y Chang | Cancer Cell | 2016 | 27070700 | No |
| 3393 | 3757 | 1252.3 | 112.2 | 37.4 | A sensitive and reliable locomotor rating scale for open field testing in rats. | D M Basso, M S Beattie, J C Bresnahan | J Neurotrauma | 1995 | 7783230 | Yes |
| 3394 | 1252 | 1252.0 | 32.0 | 32.0 | Two-stage model of memory trace formation: a role for "noisy" brain states. | G Buzsaki | Neuroscience | 1989 | 2687720 | No |
| 3395 | 3755 | 1251.7 | 149.3 | 49.8 | Neighborhoods and violent crime: a multilevel study of collective efficacy. | R J Sampson, S W Raudenbush, F Earls | Science | 1997 | 9252316 | Yes |
| 3396 | 3755 | 1251.7 | 123.7 | 41.2 | Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. | Irith Wiegand, Kai Hilpert, Robert E W Hancock | Nat Protoc | 2008 | 18274517 | Yes |
| 3397 | 3755 | 1251.7 | 129.2 | 43.1 | Stimuli-responsive nanocarriers for drug delivery. | Simona Mura, Julien Nicolas, Patrick Couvreur | Nat Mater | 2013 | 24150417 | No |
| 3398 | 2503 | 1251.5 | 56.0 | 28.0 | Finding and evaluating community structure in networks. | M E J Newman, M Girvan | Phys Rev E Stat Nonlin Soft Matter Phys | 2004 | 14995526 | Yes |
| 3399 | 2502 | 1251.0 | 98.3 | 49.1 | Societal and individual determinants of medical care utilization in the United States. | R Andersen, J F Newman | Milbank Mem Fund Q Health Soc | 1973 | 4198894 | Yes |
| 3400 | 6255 | 1251.0 | 227.7 | 45.5 | Posttraumatic stress disorder in the National Comorbidity Survey. | R C Kessler, A Sonnega, E Bromet, M Hughes, C B Nelson | Arch Gen Psychiatry | 1995 | 7492257 | Yes |
| 3401 | 1251 | 1251.0 | 36.1 | 36.1 | Cellular and molecular mechanisms of renal fibrosis. | Youhua Liu | Nat Rev Nephrol | 2011 | 22009250 | No |
| 3402 | 1251 | 1251.0 | 66.4 | 66.4 | Cisplatin: The first metal based anticancer drug. | Sumit Ghosh | Bioorg Chem | 2019 | 31003078 | No |
| 3403 | 2501 | 1250.5 | 65.7 | 32.9 | Genetic dissection of complex traits. | E S Lander, N J Schork | Science | 1994 | 8091226 | No |
| 3404 | 3751 | 1250.3 | 85.4 | 28.5 | Population structure and eigenanalysis. | Nick Patterson, Alkes L Price, David Reich | PLoS Genet | 2006 | 17194218 | Yes |
| 3405 | 2500 | 1250.0 | 71.9 | 36.0 | Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. | R G Phillips, J E LeDoux | Behav Neurosci | 1992 | 1590953 | Yes |
| 3406 | 1250 | 1250.0 | 50.4 | 50.4 | Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. | Peter J Barnes | J Allergy Clin Immunol | 2016 | 27373322 | No |
| 3407 | 2499 | 1249.5 | 77.2 | 38.6 | Natural products as sources of new drugs over the last 25 years. | David J Newman, Gordon M Cragg | J Nat Prod | 2007 | 17309302 | No |
| 3408 | 1249 | 1249.0 | 76.1 | 76.1 | The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement. | M M Panjabi | J Spinal Disord | 1992 | 1490034 | Yes |
| 3409 | 1249 | 1249.0 | 22.4 | 22.4 | Stem cells: units of development, units of regeneration, and units in evolution. | I L Weissman | Cell | 2000 | 10647940 | No |
| 3410 | 1249 | 1249.0 | 48.5 | 48.5 | Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). | F Berenbaum | Osteoarthritis Cartilage | 2013 | 23194896 | No |
| 3411 | 13734 | 1248.5 | 473.4 | 43.0 | A global reference for human genetic variation. | , Adam Auton, Lisa D Brooks, Richard M Durbin, Erik P Garrison, Hyun Min Kang, Jan O Korbel, Jonathan L Marchini, Shane McCarthy, Gil A McVean, Goncalo R Abecasis | Nature | 2015 | 26432245 | Yes |
| 3412 | 1248 | 1248.0 | 35.8 | 35.8 | Structure and function of intercellular junctions. | L A Staehelin | Int Rev Cytol | 1974 | 4611943 | No |
| 3413 | 1248 | 1248.0 | 33.2 | 33.2 | Mode of action of membrane active antimicrobial peptides. | Yechiel Shai | Biopolymers | 2002 | 12491537 | No |
| 3414 | 2495 | 1247.5 | 78.3 | 39.1 | Health effects of fine particulate air pollution: lines that connect. | C Arden Pope, Douglas W Dockery | J Air Waste Manag Assoc | 2006 | 16805397 | No |
| 3415 | 1247 | 1247.0 | 20.9 | 20.9 | Antigen receptor tail clue. | M Reth | Nature | 1989 | 2927501 | Yes |
| 3416 | 1247 | 1247.0 | 36.5 | 36.5 | The neurobiology of stress: from serendipity to clinical relevance. | B S McEwen | Brain Res | 2000 | 11119695 | No |
| 3417 | 1247 | 1247.0 | 0.0 | 0.0 | Sequential tests for the detection of linkage. | N E Morton | Am J Hum Genet | 1955 | 13258560 | Yes |
| 3418 | 1247 | 1247.0 | 34.3 | 34.3 | Neural stimulation and recording electrodes. | Stuart F Cogan | Annu Rev Biomed Eng | 2008 | 18429704 | No |
| 3419 | 1247 | 1247.0 | 47.3 | 47.3 | Autonomic nervous system activity in emotion: a review. | Sylvia D Kreibig | Biol Psychol | 2010 | 20371374 | No |
| 3420 | 1247 | 1247.0 | 35.4 | 35.4 | Cyclin-dependent kinases. | Marcos Malumbres | Genome Biol | 2014 | 25180339 | No |
| 3421 | 2494 | 1247.0 | 190.6 | 95.3 | Mental Health and the Covid-19 Pandemic. | Betty Pfefferbaum, Carol S North | N Engl J Med | 2020 | 32283003 | Yes |
| 3422 | 3739 | 1246.3 | 110.1 | 36.7 | AMPK: a nutrient and energy sensor that maintains energy homeostasis. | D Grahame Hardie, Fiona A Ross, Simon A Hawley | Nat Rev Mol Cell Biol | 2012 | 22436748 | No |
| 3423 | 14956 | 1246.3 | 463.6 | 38.6 | Ferroptosis: an iron-dependent form of nonapoptotic cell death. | Scott J Dixon, Kathryn M Lemberg, Michael R Lamprecht, Rachid Skouta, Eleina M Zaitsev, Caroline E Gleason, Darpan N Patel, Andras J Bauer, Alexandra M Cantley, Wan Seok Yang, Barclay Morrison, Brent R Stockwell | Cell | 2012 | 22632970 | Yes |
| 3424 | 2492 | 1246.0 | 63.6 | 31.8 | Molecular mechanisms of action of steroid/thyroid receptor superfamily members. | M J Tsai, B W O'Malley | Annu Rev Biochem | 1994 | 7979245 | No |
| 3425 | 7476 | 1246.0 | 145.1 | 24.2 | Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. | S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T Tuschl | Nature | 2001 | 11373684 | Yes |
| 3426 | 1246 | 1246.0 | 47.8 | 47.8 | The pain self-efficacy questionnaire: Taking pain into account. | Michael K Nicholas | Eur J Pain | 2007 | 16446108 | Yes |
| 3427 | 1246 | 1246.0 | 48.3 | 48.3 | A polarizing question: do M1 and M2 microglia exist? | Richard M Ransohoff | Nat Neurosci | 2016 | 27459405 | No |
| 3428 | 1246 | 1246.0 | 244.8 | 244.8 | ChatGPT Utility in Healthcare Education, Research, and Practice: Systematic Review on the Promising Perspectives and Valid Concerns. | Malik Sallam | Healthcare (Basel) | 2023 | 36981544 | No |
| 3429 | 1245 | 1245.0 | 28.2 | 28.2 | Life, death, and the pursuit of apoptosis. | E White | Genes Dev | 1996 | 8557188 | No |
| 3430 | 1245 | 1245.0 | 25.4 | 25.4 | Liver regeneration: from myth to mechanism. | Rebecca Taub | Nat Rev Mol Cell Biol | 2004 | 15459664 | No |
| 3431 | 1245 | 1245.0 | 34.0 | 34.0 | Inflammation 2010: new adventures of an old flame. | Ruslan Medzhitov | Cell | 2010 | 20303867 | No |
| 3432 | 19915 | 1244.7 | 774.1 | 48.4 | SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. | Anton Bankevich, Sergey Nurk, Dmitry Antipov, Alexey A Gurevich, Mikhail Dvorkin, Alexander S Kulikov, Valery M Lesin, Sergey I Nikolenko, Son Pham, Andrey D Prjibelski, Alexey V Pyshkin, Alexander V Sirotkin, Nikolay Vyahhi, Glenn Tesler, Max A Alekseyev, Pavel A Pevzner | J Comput Biol | 2012 | 22506599 | Yes |
| 3433 | 2489 | 1244.5 | 56.5 | 28.2 | Toll-like receptors in innate immunity. | Kiyoshi Takeda, Shizuo Akira | Int Immunol | 2005 | 15585605 | No |
| 3434 | 2489 | 1244.5 | 56.0 | 28.0 | Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. | Jing Yang, Robert A Weinberg | Dev Cell | 2008 | 18539112 | No |
| 3435 | 1244 | 1244.0 | 38.3 | 38.3 | Riddle of biofilm resistance. | K Lewis | Antimicrob Agents Chemother | 2001 | 11257008 | No |
| 3436 | 4975 | 1243.8 | 136.4 | 34.1 | Gene ontology analysis for RNA-seq: accounting for selection bias. | Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia Oshlack | Genome Biol | 2010 | 20132535 | Yes |
| 3437 | 2487 | 1243.5 | 54.8 | 27.4 | Atherosclerosis. the road ahead. | C K Glass, J L Witztum | Cell | 2001 | 11239408 | No |
| 3438 | 2487 | 1243.5 | 52.7 | 26.4 | The mammalian unfolded protein response. | Martin Schroder, Randal J Kaufman | Annu Rev Biochem | 2005 | 15952902 | No |
| 3439 | 2487 | 1243.5 | 67.5 | 33.8 | Localized surface plasmon resonance spectroscopy and sensing. | Katherine A Willets, Richard P Van Duyne | Annu Rev Phys Chem | 2007 | 17067281 | No |
| 3440 | 2487 | 1243.5 | 101.0 | 50.5 | Shared decision making--pinnacle of patient-centered care. | Michael J Barry, Susan Edgman-Levitan | N Engl J Med | 2012 | 22375967 | Yes |
| 3441 | 3728 | 1242.7 | 138.9 | 46.3 | The weirdest people in the world? | Joseph Henrich, Steven J Heine, Ara Norenzayan | Behav Brain Sci | 2010 | 20550733 | Yes |
| 3442 | 2485 | 1242.5 | 62.7 | 31.4 | Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. | Sophia Y Lunt, Matthew G Vander Heiden | Annu Rev Cell Dev Biol | 2011 | 21985671 | No |
| 3443 | 1242 | 1242.0 | 60.0 | 60.0 | Continuous improvement as an ideal in health care. | D M Berwick | N Engl J Med | 1989 | 2909878 | Yes |
| 3444 | 1242 | 1242.0 | 24.4 | 24.4 | Lipid rafts: elusive or illusive? | Sean Munro | Cell | 2003 | 14622593 | No |
| 3445 | 1242 | 1242.0 | 41.8 | 41.8 | The broaden-and-build theory of positive emotions. | Barbara L Fredrickson | Philos Trans R Soc Lond B Biol Sci | 2004 | 15347528 | No |
| 3446 | 1242 | 1242.0 | 35.8 | 35.8 | Cholinesterase inhibitors for Alzheimer's disease. | J Birks | Cochrane Database Syst Rev | 2006 | 16437532 | Yes |
| 3447 | 1242 | 1242.0 | 24.6 | 24.6 | Models, mechanisms and clinical evidence for cancer dormancy. | Julio A Aguirre-Ghiso | Nat Rev Cancer | 2007 | 17957189 | No |
| 3448 | 1241 | 1241.0 | 63.3 | 63.3 | Osseointegration and its experimental background. | P I Branemark | J Prosthet Dent | 1983 | 6352924 | No |
| 3449 | 1241 | 1241.0 | 45.0 | 45.0 | Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators. | B A Hess | Phys Rev A Gen Phys | 1986 | 9897114 | Yes |
| 3450 | 2482 | 1241.0 | 71.9 | 36.0 | Fitness effects on the cognitive function of older adults: a meta-analytic study. | Stanley Colcombe, Arthur F Kramer | Psychol Sci | 2003 | 12661673 | Yes |
| 3451 | 1241 | 1241.0 | 0.0 | 0.0 | A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. | M G Buonocore | J Dent Res | 1955 | 13271655 | Yes |
| 3452 | 1241 | 1241.0 | 0.0 | 0.0 | Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. | J M Van Rossum | Arch Int Pharmacodyn Ther | 1963 | 13996119 | Yes |
| 3453 | 1240 | 1240.0 | 29.0 | 29.0 | The columnar organization of the neocortex. | V B Mountcastle | Brain | 1997 | 9153131 | No |
| 3454 | 1240 | 1240.0 | 29.9 | 29.9 | Mitochondrial transport of cations: channels, exchangers, and permeability transition. | P Bernardi | Physiol Rev | 1999 | 10508231 | No |
| 3455 | 2480 | 1240.0 | 0.0 | 0.0 | The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. | B N Ames, D T Dubin | J Biol Chem | 1960 | 13793161 | Yes |
| 3456 | 3720 | 1240.0 | 87.6 | 29.2 | Obesity induces a phenotypic switch in adipose tissue macrophage polarization. | Carey N Lumeng, Jennifer L Bodzin, Alan R Saltiel | J Clin Invest | 2007 | 17200717 | Yes |
| 3457 | 2480 | 1240.0 | 74.5 | 37.2 | Genome-wide efficient mixed-model analysis for association studies. | Xiang Zhou, Matthew Stephens | Nat Genet | 2012 | 22706312 | Yes |
| 3458 | 6198 | 1239.6 | 200.2 | 40.0 | Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. | J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman | Proc Natl Acad Sci U S A | 1990 | 2154753 | Yes |
| 3459 | 2478 | 1239.0 | 56.6 | 28.3 | Adaptive protein evolution at the Adh locus in Drosophila. | J H McDonald, M Kreitman | Nature | 1991 | 1904993 | Yes |
| 3460 | 1239 | 1239.0 | 37.4 | 37.4 | Papillary and follicular thyroid carcinoma. | M J Schlumberger | N Engl J Med | 1998 | 9445411 | No |
| 3461 | 2478 | 1239.0 | 73.4 | 36.7 | Imaging cognition II: An empirical review of 275 PET and fMRI studies. | R Cabeza, L Nyberg | J Cogn Neurosci | 2000 | 10769304 | No |
| 3462 | 1239 | 1239.0 | 40.4 | 40.4 | Chronic stress, drug use, and vulnerability to addiction. | Rajita Sinha | Ann N Y Acad Sci | 2008 | 18991954 | No |
| 3463 | 2478 | 1239.0 | 76.3 | 38.1 | Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. | S Geman, D Geman | IEEE Trans Pattern Anal Mach Intell | 1984 | 22499653 | Yes |
| 3464 | 2478 | 1239.0 | 93.4 | 46.7 | Ferroptosis: Death by Lipid Peroxidation. | Wan Seok Yang, Brent R Stockwell | Trends Cell Biol | 2016 | 26653790 | No |
| 3465 | 3717 | 1239.0 | 129.9 | 43.3 | The MaxQuant computational platform for mass spectrometry-based shotgun proteomics. | Stefka Tyanova, Tikira Temu, Juergen Cox | Nat Protoc | 2016 | 27809316 | Yes |
| 3466 | 1238 | 1238.0 | 42.5 | 42.5 | How is the level of free arachidonic acid controlled in mammalian cells? | R F Irvine | Biochem J | 1982 | 6810878 | No |
| 3467 | 1238 | 1238.0 | 54.8 | 54.8 | Beyond curriculum reform: confronting medicine's hidden curriculum. | F W Hafferty | Acad Med | 1998 | 9580717 | Yes |
| 3468 | 2476 | 1238.0 | 79.4 | 39.7 | Photoacoustic tomography: in vivo imaging from organelles to organs. | Lihong V Wang, Song Hu | Science | 2012 | 22442475 | No |
| 3469 | 2475 | 1237.5 | 39.9 | 19.9 | A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. | D Tautz, C Pfeifle | Chromosoma | 1989 | 2476281 | Yes |
| 3470 | 2475 | 1237.5 | 67.0 | 33.5 | The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. | Maria M Mihaylova, Reuben J Shaw | Nat Cell Biol | 2011 | 21892142 | No |
| 3471 | 4949 | 1237.2 | 136.2 | 34.0 | Mussel-inspired surface chemistry for multifunctional coatings. | Haeshin Lee, Shara M Dellatore, William M Miller, Phillip B Messersmith | Science | 2007 | 17947576 | Yes |
| 3472 | 1237 | 1237.0 | 37.7 | 37.7 | Calcium channel modulation by neurotransmitters, enzymes and drugs. | H Reuter | Nature | 1983 | 6131381 | No |
| 3473 | 3710 | 1236.7 | 117.4 | 39.1 | Hepatocellular carcinoma. | Alejandro Forner, Josep M Llovet, Jordi Bruix | Lancet | 2012 | 22353262 | No |
| 3474 | 2473 | 1236.5 | 75.1 | 37.5 | Reactive oxygen species, cellular redox systems, and apoptosis. | Magdalena L Circu, Tak Yee Aw | Free Radic Biol Med | 2010 | 20045723 | No |
| 3475 | 3709 | 1236.3 | 102.1 | 34.0 | Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. | Robert G Hart, Lesly A Pearce, Maria I Aguilar | Ann Intern Med | 2007 | 17577005 | Yes |
| 3476 | 2472 | 1236.0 | 100.9 | 50.5 | A real-time QRS detection algorithm. | J Pan, W J Tompkins | IEEE Trans Biomed Eng | 1985 | 3997178 | Yes |
| 3477 | 1236 | 1236.0 | 26.9 | 26.9 | Apoptosis in neurodegenerative disorders. | M P Mattson | Nat Rev Mol Cell Biol | 2000 | 11253364 | No |
| 3478 | 1236 | 1236.0 | 32.7 | 32.7 | Seed Germination and Dormancy. | J D Bewley | Plant Cell | 1997 | 12237375 | Yes |
| 3479 | 1236 | 1236.0 | 34.4 | 34.4 | Principles of c-di-GMP signalling in bacteria. | Regine Hengge | Nat Rev Microbiol | 2009 | 19287449 | No |
| 3480 | 3706 | 1235.3 | 134.1 | 44.7 | IL-6 in inflammation, immunity, and disease. | Toshio Tanaka, Masashi Narazaki, Tadamitsu Kishimoto | Cold Spring Harb Perspect Biol | 2014 | 25190079 | No |
| 3481 | 1235 | 1235.0 | 29.0 | 29.0 | Translating cell biology into therapeutic advances in Alzheimer's disease. | D J Selkoe | Nature | 1999 | 10392577 | No |
| 3482 | 1235 | 1235.0 | 0.0 | 0.0 | Voluntary strength and fatigue. | P A Merton | J Physiol | 1954 | 13152698 | Yes |
| 3483 | 1235 | 1235.0 | 39.1 | 39.1 | On the mechanisms of biocompatibility. | David F Williams | Biomaterials | 2008 | 18440630 | No |
| 3484 | 3705 | 1235.0 | 110.1 | 36.7 | Macrophage biology in development, homeostasis and disease. | Thomas A Wynn, Ajay Chawla, Jeffrey W Pollard | Nature | 2013 | 23619691 | No |
| 3485 | 1234 | 1234.0 | 67.5 | 67.5 | A "rationalized" arcsine transform. | G A Studebaker | J Speech Hear Res | 1985 | 4046587 | Yes |
| 3486 | 1234 | 1234.0 | 123.3 | 123.3 | The analysis of errors in orthodontic measurements. | W J Houston | Am J Orthod | 1983 | 6573846 | Yes |
| 3487 | 2468 | 1234.0 | 58.7 | 29.4 | Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. | N Sreerama, R W Woody | Anal Biochem | 2000 | 11112271 | Yes |
| 3488 | 1234 | 1234.0 | 25.4 | 25.4 | Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. | Harold F Dvorak | J Clin Oncol | 2002 | 12409337 | No |
| 3489 | 2468 | 1234.0 | 49.6 | 24.8 | Tumour-cell invasion and migration: diversity and escape mechanisms. | Peter Friedl, Katarina Wolf | Nat Rev Cancer | 2003 | 12724734 | No |
| 3490 | 1234 | 1234.0 | 36.4 | 36.4 | The mechanisms of alloxan- and streptozotocin-induced diabetes. | S Lenzen | Diabetologia | 2008 | 18087688 | No |
| 3491 | 4929 | 1232.2 | 141.8 | 35.5 | Place navigation impaired in rats with hippocampal lesions. | R G Morris, P Garrud, J N Rawlins, J O'Keefe | Nature | 1982 | 7088155 | Yes |
| 3492 | 1232 | 1232.0 | 26.0 | 26.0 | Morphogenetic roles of classic cadherins. | M Takeichi | Curr Opin Cell Biol | 1995 | 8573335 | No |
| 3493 | 1232 | 1232.0 | 27.3 | 27.3 | Twilight zone of protein sequence alignments. | B Rost | Protein Eng | 1999 | 10195279 | Yes |
| 3494 | 1232 | 1232.0 | 27.1 | 27.1 | Caspase structure, proteolytic substrates, and function during apoptotic cell death. | D W Nicholson | Cell Death Differ | 1999 | 10578171 | No |
| 3495 | 4928 | 1232.0 | 207.1 | 51.8 | From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. | Ara Koh, Filipe De Vadder, Petia Kovatcheva-Datchary, Fredrik Backhed | Cell | 2016 | 27259147 | No |
| 3496 | 2463 | 1231.5 | 63.1 | 31.6 | Quorum sensing: cell-to-cell communication in bacteria. | Christopher M Waters, Bonnie L Bassler | Annu Rev Cell Dev Biol | 2005 | 16212498 | No |
| 3497 | 2463 | 1231.5 | 182.6 | 91.3 | Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? | Fangda Leng, Paul Edison | Nat Rev Neurol | 2021 | 33318676 | No |
| 3498 | 2462 | 1231.0 | 107.8 | 53.9 | Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. | L A Clark, D Watson | J Abnorm Psychol | 1991 | 1918611 | No |
| 3499 | 1231 | 1231.0 | 60.9 | 60.9 | ROC methodology in radiologic imaging. | C E Metz | Invest Radiol | 1986 | 3095258 | No |
| 3500 | 1231 | 1231.0 | 39.6 | 39.6 | Relations between the statistics of natural images and the response properties of cortical cells. | D J Field | J Opt Soc Am A | 1987 | 3430225 | Yes |
| 3501 | 2462 | 1231.0 | 53.7 | 26.9 | The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. | A Bairoch, R Apweiler | Nucleic Acids Res | 2000 | 10592178 | Yes |
| 3502 | 1231 | 1231.0 | 34.1 | 34.1 | Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. | Gregg L Semenza | Trends Pharmacol Sci | 2012 | 22398146 | No |
| 3503 | 1231 | 1231.0 | 41.9 | 41.9 | The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments. | Peter C Austin | Stat Med | 2014 | 24122911 | Yes |
| 3504 | 2460 | 1230.0 | 76.0 | 38.0 | Recent advances in the phencyclidine model of schizophrenia. | D C Javitt, S R Zukin | Am J Psychiatry | 1991 | 1654746 | No |
| 3505 | 1230 | 1230.0 | 24.7 | 24.7 | STATs: signal transducers and activators of transcription. | J N Ihle | Cell | 1996 | 8608586 | No |
| 3506 | 1230 | 1230.0 | 39.1 | 39.1 | On the utility of P3 amplitude as a measure of processing capacity. | A Kok | Psychophysiology | 2001 | 11352145 | No |
| 3507 | 2460 | 1230.0 | 56.2 | 28.1 | microRNA functions. | Natascha Bushati, Stephen M Cohen | Annu Rev Cell Dev Biol | 2007 | 17506695 | No |
| 3508 | 1230 | 1230.0 | 33.7 | 33.7 | Neuronal gamma-band synchronization as a fundamental process in cortical computation. | Pascal Fries | Annu Rev Neurosci | 2009 | 19400723 | No |
| 3509 | 2458 | 1229.0 | 89.8 | 44.9 | The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. | G P Chrousos, P W Gold | JAMA | 1992 | 1538563 | No |
| 3510 | 1229 | 1229.0 | 35.3 | 35.3 | Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. | F Hefti | J Neurosci | 1986 | 3746405 | Yes |
| 3511 | 7374 | 1229.0 | 197.4 | 32.9 | Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. | Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins, | Lancet | 2002 | 12493255 | Yes |
| 3512 | 2458 | 1229.0 | 107.1 | 53.5 | Epidemiology of adult fractures: A review. | Charles M Court-Brown, Ben Caesar | Injury | 2006 | 16814787 | No |
| 3513 | 1229 | 1229.0 | 27.5 | 27.5 | Next-generation DNA sequencing methods. | Elaine R Mardis | Annu Rev Genomics Hum Genet | 2008 | 18576944 | No |
| 3514 | 3687 | 1229.0 | 124.2 | 41.4 | The Danish National Patient Register. | Elsebeth Lynge, Jakob Lynge Sandegaard, Matejka Rebolj | Scand J Public Health | 2011 | 21775347 | Yes |
| 3515 | 2458 | 1229.0 | 63.5 | 31.8 | Cancer epigenetics: from mechanism to therapy. | Mark A Dawson, Tony Kouzarides | Cell | 2012 | 22770212 | No |
| 3516 | 1229 | 1229.0 | 44.1 | 44.1 | Microbial life in the phyllosphere. | Julia A Vorholt | Nat Rev Microbiol | 2012 | 23154261 | No |
| 3517 | 2457 | 1228.5 | 53.5 | 26.8 | Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. | G K McMaster, G G Carmichael | Proc Natl Acad Sci U S A | 1977 | 73185 | Yes |
| 3518 | 1228 | 1228.0 | 27.6 | 27.6 | The epidemiologic transition. A theory of the epidemiology of population change. | A R Omran | Milbank Mem Fund Q | 1971 | 5155251 | Yes |
| 3519 | 1228 | 1228.0 | 38.7 | 38.7 | Social cognition and the brain: a meta-analysis. | Frank Van Overwalle | Hum Brain Mapp | 2009 | 18381770 | Yes |
| 3520 | 1228 | 1228.0 | 36.7 | 36.7 | Normal bone anatomy and physiology. | Bart Clarke | Clin J Am Soc Nephrol | 2008 | 18988698 | No |
| 3521 | 1228 | 1228.0 | 37.9 | 37.9 | Graves' ophthalmopathy. | Rebecca S Bahn | N Engl J Med | 2010 | 20181974 | No |
| 3522 | 1227 | 1227.0 | 25.9 | 25.9 | Intracellular protein topogenesis. | G Blobel | Proc Natl Acad Sci U S A | 1980 | 6929499 | Yes |
| 3523 | 2453 | 1226.5 | 82.1 | 41.0 | Physiological parameters in laboratory animals and humans. | B Davies, T Morris | Pharm Res | 1993 | 8378254 | No |
| 3524 | 2453 | 1226.5 | 54.4 | 27.2 | Roles of CHOP/GADD153 in endoplasmic reticulum stress. | S Oyadomari, M Mori | Cell Death Differ | 2004 | 14685163 | No |
| 3525 | 3679 | 1226.3 | 113.9 | 38.0 | Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. | H King, R E Aubert, W H Herman | Diabetes Care | 1998 | 9727886 | Yes |
| 3526 | 1226 | 1226.0 | 35.0 | 35.0 | Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. | P O Seglen | Exp Cell Res | 1973 | 4358115 | Yes |
| 3527 | 1226 | 1226.0 | 28.3 | 28.3 | Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. | T A Springer | Annu Rev Physiol | 1995 | 7778885 | No |
| 3528 | 2451 | 1225.5 | 47.5 | 23.8 | Rho GTPases: biochemistry and biology. | Aron B Jaffe, Alan Hall | Annu Rev Cell Dev Biol | 2005 | 16212495 | No |
| 3529 | 2451 | 1225.5 | 72.2 | 36.1 | Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. | Amit Etkin, Tor D Wager | Am J Psychiatry | 2007 | 17898336 | Yes |
| 3530 | 3676 | 1225.3 | 203.6 | 67.9 | Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG) | P L Hudak, P C Amadio, C Bombardier | Am J Ind Med | 1996 | 8773720 | Yes |
| 3531 | 3676 | 1225.3 | 76.1 | 25.4 | Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. | Juri Rappsilber, Matthias Mann, Yasushi Ishihama | Nat Protoc | 2007 | 17703201 | Yes |
| 3532 | 1225 | 1225.0 | 29.5 | 29.5 | Growth factors and cancer. | S A Aaronson | Science | 1991 | 1659742 | No |
| 3533 | 1225 | 1225.0 | 79.9 | 79.9 | Impingement lesions. | C S Neer | Clin Orthop Relat Res | 1983 | 6825348 | Yes |
| 3534 | 1225 | 1225.0 | 32.3 | 32.3 | The neuropathology of schizophrenia. A critical review of the data and their interpretation. | P J Harrison | Brain | 1999 | 10219775 | No |
| 3535 | 1225 | 1225.0 | 40.7 | 40.7 | Social support and patient adherence to medical treatment: a meta-analysis. | M Robin DiMatteo | Health Psychol | 2004 | 15008666 | Yes |
| 3536 | 1225 | 1225.0 | 32.5 | 32.5 | Fibrinogen and fibrin structure and functions. | M W Mosesson | J Thromb Haemost | 2005 | 16102057 | No |
| 3537 | 6124 | 1224.8 | 184.9 | 37.0 | Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. | Carol Kilkenny, William J Browne, Innes C Cuthill, Michael Emerson, Douglas G Altman | PLoS Biol | 2010 | 20613859 | No |
| 3538 | 2449 | 1224.5 | 46.7 | 23.4 | The druggable genome. | Andrew L Hopkins, Colin R Groom | Nat Rev Drug Discov | 2002 | 12209152 | No |
| 3539 | 12242 | 1224.2 | 290.8 | 29.1 | Scalable molecular dynamics with NAMD. | James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kale, Klaus Schulten | J Comput Chem | 2005 | 16222654 | Yes |
| 3540 | 1224 | 1224.0 | 26.8 | 26.8 | Antigen-presenting function of the macrophage. | E R Unanue | Annu Rev Immunol | 1984 | 6242349 | No |
| 3541 | 1224 | 1224.0 | 22.4 | 22.4 | Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. | H E Ruley | Nature | 1983 | 6308473 | Yes |
| 3542 | 1224 | 1224.0 | 31.8 | 31.8 | Endothelial-leukocyte adhesion molecules. | M P Bevilacqua | Annu Rev Immunol | 1993 | 8476577 | No |
| 3543 | 1224 | 1224.0 | 0.0 | 0.0 | Fertilizing capacity of spermatozoa deposited into the fallopian tubes. | M C Chang | Nature | 1951 | 14882325 | Yes |
| 3544 | 1224 | 1224.0 | 24.0 | 24.0 | Regulation of cadherin-mediated adhesion in morphogenesis. | Barry M Gumbiner | Nat Rev Mol Cell Biol | 2005 | 16025097 | No |
| 3545 | 2447 | 1223.5 | 110.8 | 55.4 | Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. | P R Hunter, M A Gaston | J Clin Microbiol | 1988 | 3069867 | Yes |
| 3546 | 2447 | 1223.5 | 62.6 | 31.3 | Adipocytokines: mediators linking adipose tissue, inflammation and immunity. | Herbert Tilg, Alexander R Moschen | Nat Rev Immunol | 2006 | 16998510 | No |
| 3547 | 3670 | 1223.3 | 197.4 | 65.8 | ShinyGO: a graphical gene-set enrichment tool for animals and plants. | Steven Xijin Ge, Dongmin Jung, Runan Yao | Bioinformatics | 2020 | 31882993 | Yes |
| 3548 | 1223 | 1223.0 | 42.6 | 42.6 | The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. | N M Kaplan | Arch Intern Med | 1989 | 2662932 | No |
| 3549 | 1223 | 1223.0 | 34.4 | 34.4 | What is synergy? | M C Berenbaum | Pharmacol Rev | 1989 | 2692037 | No |
| 3550 | 1223 | 1223.0 | 27.6 | 27.6 | Dendritic cells: unique leukocyte populations which control the primary immune response. | D N Hart | Blood | 1997 | 9345009 | No |
| 3551 | 1223 | 1223.0 | 34.4 | 34.4 | Unequal treatment: confronting racial and ethnic disparities in health care. | Alan Nelson | J Natl Med Assoc | 2002 | 12152921 | No |
| 3552 | 1223 | 1223.0 | 39.8 | 39.8 | Staphylococcus epidermidis--the 'accidental' pathogen. | Michael Otto | Nat Rev Microbiol | 2009 | 19609257 | No |
| 3553 | 1222 | 1222.0 | 49.2 | 49.2 | Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. | J T Daugirdas | J Am Soc Nephrol | 1993 | 8305648 | Yes |
| 3554 | 1222 | 1222.0 | 21.3 | 21.3 | Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. | M S Wold | Annu Rev Biochem | 1997 | 9242902 | No |
| 3555 | 1222 | 1222.0 | 54.3 | 54.3 | How Many Subjects Does It Take To Do A Regression Analysis. | S B Green | Multivariate Behav Res | 1991 | 26776715 | Yes |
| 3556 | 2443 | 1221.5 | 58.1 | 29.1 | Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. | Josep M Llovet, Jordi Bruix | Hepatology | 2003 | 12540794 | Yes |
| 3557 | 3664 | 1221.3 | 78.4 | 26.1 | Large-scale analysis of the yeast proteome by multidimensional protein identification technology. | M P Washburn, D Wolters, J R Yates | Nat Biotechnol | 2001 | 11231557 | Yes |
| 3558 | 1221 | 1221.0 | 37.5 | 37.5 | The mysteries of lipoprotein(a). | G Utermann | Science | 1989 | 2530631 | No |
| 3559 | 1221 | 1221.0 | 34.2 | 34.2 | The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. | R A Jain | Biomaterials | 2000 | 11055295 | No |
| 3560 | 3663 | 1221.0 | 62.5 | 20.8 | A system for stable expression of short interfering RNAs in mammalian cells. | Thijn R Brummelkamp, Rene Bernards, Reuven Agami | Science | 2002 | 11910072 | Yes |
| 3561 | 1221 | 1221.0 | 0.0 | 0.0 | A New Serum Type System In Man--The Lp System. | K Berg | Acta Pathol Microbiol Scand | 1963 | 14064818 | Yes |
| 3562 | 1221 | 1221.0 | 28.6 | 28.6 | What is principal component analysis? | Markus Ringner | Nat Biotechnol | 2008 | 18327243 | Yes |
| 3563 | 1220 | 1220.0 | 40.6 | 40.6 | Epidemiology of heart failure. | Veronique L Roger | Circ Res | 2013 | 23989710 | No |
| 3564 | 3659 | 1219.7 | 95.4 | 31.8 | Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. | C R Woese, O Kandler, M L Wheelis | Proc Natl Acad Sci U S A | 1990 | 2112744 | Yes |
| 3565 | 2439 | 1219.5 | 45.5 | 22.8 | Hedgehog signaling in animal development: paradigms and principles. | P W Ingham, A P McMahon | Genes Dev | 2001 | 11731473 | No |
| 3566 | 1219 | 1219.0 | 30.5 | 30.5 | Differential projections of the infralimbic and prelimbic cortex in the rat. | Robert P Vertes | Synapse | 2004 | 14579424 | Yes |
| 3567 | 2438 | 1219.0 | 55.6 | 27.8 | Regeneration beyond the glial scar. | Jerry Silver, Jared H Miller | Nat Rev Neurosci | 2004 | 14735117 | No |
| 3568 | 1219 | 1219.0 | 40.7 | 40.7 | Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. | Jeffrey N Katz | J Bone Joint Surg Am | 2006 | 16595438 | No |
| 3569 | 1219 | 1219.0 | 47.6 | 47.6 | Epithelial Mesenchymal Transition in Tumor Metastasis. | Vivek Mittal | Annu Rev Pathol | 2018 | 29414248 | No |
| 3570 | 2437 | 1218.5 | 43.3 | 21.6 | A synthetic oscillatory network of transcriptional regulators. | M B Elowitz, S Leibler | Nature | 2000 | 10659856 | Yes |
| 3571 | 2437 | 1218.5 | 0.0 | 0.0 | The Aggregation Of Blood Platelets. | G V Born, M J Cross | J Physiol | 1963 | 14056485 | Yes |
| 3572 | 2437 | 1218.5 | 83.3 | 41.6 | Glycosylation in cancer: mechanisms and clinical implications. | Salome S Pinho, Celso A Reis | Nat Rev Cancer | 2015 | 26289314 | No |
| 3573 | 2436 | 1218.0 | 72.9 | 36.5 | Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. | P Brugada, J Brugada | J Am Coll Cardiol | 1992 | 1309182 | Yes |
| 3574 | 1218 | 1218.0 | 46.2 | 46.2 | View through a window may influence recovery from surgery. | R S Ulrich | Science | 1984 | 6143402 | Yes |
| 3575 | 4872 | 1218.0 | 129.7 | 32.4 | Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. | Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod Menon | Proc Natl Acad Sci U S A | 2003 | 12506194 | Yes |
| 3576 | 1218 | 1218.0 | 0.0 | 0.0 | The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. | R E Hope-Simpson | Proc R Soc Med | 1965 | 14267505 | Yes |
| 3577 | 1218 | 1218.0 | 28.8 | 28.8 | Pathogenesis of atherosclerosis. | Erling Falk | J Am Coll Cardiol | 2006 | 16631513 | Yes |
| 3578 | 1218 | 1218.0 | 45.2 | 45.2 | Constructive and unconstructive repetitive thought. | Edward R Watkins | Psychol Bull | 2008 | 18298268 | No |
| 3579 | 2436 | 1218.0 | 72.9 | 36.5 | Long non-coding RNAs: new players in cell differentiation and development. | Alessandro Fatica, Irene Bozzoni | Nat Rev Genet | 2014 | 24296535 | No |
| 3580 | 1218 | 1218.0 | 36.1 | 36.1 | Targeting the DNA Damage Response in Cancer. | Mark J O'Connor | Mol Cell | 2015 | 26590714 | No |
| 3581 | 1217 | 1217.0 | 30.3 | 30.3 | Bcl-2 initiates a new category of oncogenes: regulators of cell death. | S J Korsmeyer | Blood | 1992 | 1498330 | No |
| 3582 | 1217 | 1217.0 | 32.8 | 32.8 | Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. | G Boden | Diabetes | 1997 | 8971073 | No |
| 3583 | 7302 | 1217.0 | 164.7 | 27.4 | Obesity is associated with macrophage accumulation in adipose tissue. | Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W Ferrante | J Clin Invest | 2003 | 14679176 | Yes |
| 3584 | 1217 | 1217.0 | 28.3 | 28.3 | Structure and signalling in the IL-17 receptor family. | Sarah L Gaffen | Nat Rev Immunol | 2009 | 19575028 | No |
| 3585 | 1217 | 1217.0 | 37.5 | 37.5 | Lanthanide luminescence for biomedical analyses and imaging. | Jean-Claude G Bunzli | Chem Rev | 2010 | 20151630 | No |
| 3586 | 1217 | 1217.0 | 50.3 | 50.3 | Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. | Hannah R Snyder | Psychol Bull | 2013 | 22642228 | No |
| 3587 | 2433 | 1216.5 | 64.6 | 32.3 | Molecular mechanisms of T cell co-stimulation and co-inhibition. | Lieping Chen, Dallas B Flies | Nat Rev Immunol | 2013 | 23470321 | No |
| 3588 | 3649 | 1216.3 | 100.6 | 33.5 | Fluorine in pharmaceuticals: looking beyond intuition. | Klaus Muller, Christoph Faeh, Francois Diederich | Science | 2007 | 17901324 | No |
| 3589 | 1216 | 1216.0 | 52.9 | 52.9 | A spreading-activation theory of retrieval in sentence production. | G S Dell | Psychol Rev | 1986 | 3749399 | Yes |
| 3590 | 1216 | 1216.0 | 49.8 | 49.8 | Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. | E H Beachey | J Infect Dis | 1981 | 7014727 | No |
| 3591 | 1216 | 1216.0 | 34.6 | 34.6 | Diversity of group types, regulation, and function of phospholipase A2. | E A Dennis | J Biol Chem | 1994 | 8175726 | No |
| 3592 | 1216 | 1216.0 | 34.4 | 34.4 | Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. | Betsy Foxman | Am J Med | 2002 | 12113866 | No |
| 3593 | 1216 | 1216.0 | 32.7 | 32.7 | Redefining oxidative stress. | Dean P Jones | Antioxid Redox Signal | 2006 | 16987039 | No |
| 3594 | 1216 | 1216.0 | 37.8 | 37.8 | The enteric nervous system and neurogastroenterology. | John B Furness | Nat Rev Gastroenterol Hepatol | 2012 | 22392290 | No |
| 3595 | 2432 | 1216.0 | 126.2 | 63.1 | The neuropathological diagnosis of Alzheimer's disease. | Michael A DeTure, Dennis W Dickson | Mol Neurodegener | 2019 | 31375134 | No |
| 3596 | 2432 | 1216.0 | 122.6 | 61.3 | Cytokine Storm. | David C Fajgenbaum, Carl H June | N Engl J Med | 2020 | 33264547 | No |
| 3597 | 2430 | 1215.0 | 58.2 | 29.1 | Obesity and insulin resistance. | B B Kahn, J S Flier | J Clin Invest | 2000 | 10953022 | No |
| 3598 | 1215 | 1215.0 | 42.8 | 42.8 | On the law of effect. | R J Herrnstein | J Exp Anal Behav | 1970 | 16811440 | Yes |
| 3599 | 2429 | 1214.5 | 52.8 | 26.4 | Plant pathogens and integrated defence responses to infection. | J L Dangl, J D Jones | Nature | 2001 | 11459065 | No |
| 3600 | 2429 | 1214.5 | 69.0 | 34.5 | Strategies in the design of nanoparticles for therapeutic applications. | Robby A Petros, Joseph M DeSimone | Nat Rev Drug Discov | 2010 | 20616808 | No |
| 3601 | 7286 | 1214.3 | 265.1 | 44.2 | The occurrence of sleep-disordered breathing among middle-aged adults. | T Young, M Palta, J Dempsey, J Skatrud, S Weber, S Badr | N Engl J Med | 1993 | 8464434 | Yes |
| 3602 | 1214 | 1214.0 | 27.8 | 27.8 | The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. | S J Collins | Blood | 1987 | 3311197 | No |
| 3603 | 3642 | 1214.0 | 104.6 | 34.9 | A nonparametric method for automatic correction of intensity nonuniformity in MRI data. | J G Sled, A P Zijdenbos, A C Evans | IEEE Trans Med Imaging | 1998 | 9617910 | Yes |
| 3604 | 1214 | 1214.0 | 25.4 | 25.4 | Membrane recognition by phospholipid-binding domains. | Mark A Lemmon | Nat Rev Mol Cell Biol | 2008 | 18216767 | No |
| 3605 | 1214 | 1214.0 | 26.5 | 26.5 | Serine/threonine phosphatases: mechanism through structure. | Yigong Shi | Cell | 2009 | 19879837 | No |
| 3606 | 2427 | 1213.5 | 62.9 | 31.4 | Monocyte recruitment during infection and inflammation. | Chao Shi, Eric G Pamer | Nat Rev Immunol | 2011 | 21984070 | No |
| 3607 | 2426 | 1213.0 | 0.0 | 0.0 | High resolution acrylamide gel electrophoresis of histones. | S Panyim, R Chalkley | Arch Biochem Biophys | 1969 | 5778650 | Yes |
| 3608 | 2426 | 1213.0 | 67.7 | 33.9 | Leukocyte-endothelial adhesion molecules. | T M Carlos, J M Harlan | Blood | 1994 | 7522621 | No |
| 3609 | 1213 | 1213.0 | 55.0 | 55.0 | Development of the practice environment scale of the Nursing Work Index. | Eileen T Lake | Res Nurs Health | 2002 | 12015780 | Yes |
| 3610 | 1213 | 1213.0 | 28.9 | 28.9 | Sjögren's syndrome. | Robert I Fox | Lancet | 2005 | 16039337 | No |
| 3611 | 2426 | 1213.0 | 135.2 | 67.6 | miRDB: an online database for prediction of functional microRNA targets. | Yuhao Chen, Xiaowei Wang | Nucleic Acids Res | 2020 | 31504780 | Yes |
| 3612 | 3638 | 1212.7 | 79.1 | 26.4 | Toll-like receptors: critical proteins linking innate and acquired immunity. | S Akira, K Takeda, T Kaisho | Nat Immunol | 2001 | 11477402 | No |
| 3613 | 2425 | 1212.5 | 98.4 | 49.2 | Thirty years and counting: finding meaning in the N400 component of the event-related brain potential (ERP). | Marta Kutas, Kara D Federmeier | Annu Rev Psychol | 2011 | 20809790 | No |
| 3614 | 4850 | 1212.5 | 223.8 | 56.0 | Random effects structure for confirmatory hypothesis testing: Keep it maximal. | Dale J Barr, Roger Levy, Christoph Scheepers, Harry J Tily | J Mem Lang | 2013 | 24403724 | Yes |
| 3615 | 3637 | 1212.3 | 117.7 | 39.2 | xCell: digitally portraying the tissue cellular heterogeneity landscape. | Dvir Aran, Zicheng Hu, Atul J Butte | Genome Biol | 2017 | 29141660 | Yes |
| 3616 | 1212 | 1212.0 | 52.1 | 52.1 | Campylobacter enteritis: a "new" disease. | M B Skirrow | Br Med J | 1977 | 871765 | Yes |
| 3617 | 1212 | 1212.0 | 0.0 | 0.0 | 6-Hydroxy-dopamine induced degeneration of central monoamine neurons. | U Ungerstedt | Eur J Pharmacol | 1968 | 5718510 | Yes |
| 3618 | 1212 | 1212.0 | 30.0 | 30.0 | Matrix proteoglycans: from molecular design to cellular function. | R V Iozzo | Annu Rev Biochem | 1998 | 9759499 | No |
| 3619 | 1212 | 1212.0 | 31.6 | 31.6 | Pathogenesis of osteoporosis: concepts, conflicts, and prospects. | Lawrence G Raisz | J Clin Invest | 2005 | 16322775 | No |
| 3620 | 1212 | 1212.0 | 34.6 | 34.6 | A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. | Ron Hardman | Environ Health Perspect | 2006 | 16451849 | No |
| 3621 | 1211 | 1211.0 | 40.9 | 40.9 | Spin trapping: ESR parameters of spin adducts. | G R Buettner | Free Radic Biol Med | 1987 | 2826304 | No |
| 3622 | 1211 | 1211.0 | 23.8 | 23.8 | VEGF and the quest for tumour angiogenesis factors. | Napoleone Ferrara | Nat Rev Cancer | 2002 | 12360282 | No |
| 3623 | 2422 | 1211.0 | 75.5 | 37.8 | Burden of major musculoskeletal conditions. | Anthony D Woolf, Bruce Pfleger | Bull World Health Organ | 2003 | 14710506 | No |
| 3624 | 2422 | 1211.0 | 71.7 | 35.9 | The diversity and biogeography of soil bacterial communities. | Noah Fierer, Robert B Jackson | Proc Natl Acad Sci U S A | 2006 | 16407148 | Yes |
| 3625 | 1210 | 1210.0 | 31.0 | 31.0 | Area deprivation and widening inequalities in US mortality, 1969-1998. | Gopal K Singh | Am J Public Health | 2003 | 12835199 | Yes |
| 3626 | 1210 | 1210.0 | 32.9 | 32.9 | Gibberellin metabolism and its regulation. | Shinjiro Yamaguchi | Annu Rev Plant Biol | 2008 | 18173378 | No |
| 3627 | 3629 | 1209.7 | 0.0 | 0.0 | The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. | G Blessed, B E Tomlinson, M Roth | Br J Psychiatry | 1968 | 5662937 | Yes |
| 3628 | 2419 | 1209.5 | 65.7 | 32.9 | Antibacterial resistance worldwide: causes, challenges and responses. | Stuart B Levy, Bonnie Marshall | Nat Med | 2004 | 15577930 | No |
| 3629 | 2418 | 1209.0 | 48.8 | 24.4 | Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. | T Hunter, B M Sefton | Proc Natl Acad Sci U S A | 1980 | 6246487 | Yes |
| 3630 | 1209 | 1209.0 | 37.5 | 37.5 | The induction of pain: an integrative review. | M J Millan | Prog Neurobiol | 1999 | 9987804 | No |
| 3631 | 1209 | 1209.0 | 27.2 | 27.2 | G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. | Jeffery T Davis | Angew Chem Int Ed Engl | 2004 | 14755695 | No |
| 3632 | 4835 | 1208.8 | 192.4 | 48.1 | The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. | L B Krupp, N G LaRocca, J Muir-Nash, A D Steinberg | Arch Neurol | 1989 | 2803071 | Yes |
| 3633 | 1208 | 1208.0 | 53.3 | 53.3 | Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). | S Safe | Crit Rev Toxicol | 1990 | 2124811 | No |
| 3634 | 1208 | 1208.0 | 62.2 | 62.2 | The sociological study of stress. | L I Pearlin | J Health Soc Behav | 1989 | 2674272 | No |
| 3635 | 1208 | 1208.0 | 39.8 | 39.8 | Linkage map of Escherichia coli K-12, edition 7. | B J Bachmann | Microbiol Rev | 1983 | 6348505 | No |
| 3636 | 1208 | 1208.0 | 43.7 | 43.7 | beta-Lactamases in laboratory and clinical resistance. | D M Livermore | Clin Microbiol Rev | 1995 | 8665470 | No |
| 3637 | 2416 | 1208.0 | 65.5 | 32.8 | Rising incidence of hepatocellular carcinoma in the United States. | H B El-Serag, A C Mason | N Engl J Med | 1999 | 10072408 | Yes |
| 3638 | 1208 | 1208.0 | 27.5 | 27.5 | The finer things in X-ray diffraction data collection. | J W Pflugrath | Acta Crystallogr D Biol Crystallogr | 1999 | 10531521 | Yes |
| 3639 | 1208 | 1208.0 | 20.2 | 20.2 | Themes and variations on ubiquitylation. | A M Weissman | Nat Rev Mol Cell Biol | 2001 | 11265246 | No |
| 3640 | 1208 | 1208.0 | 36.2 | 36.2 | Conceptual synthesis in community ecology. | Mark Vellend | Q Rev Biol | 2010 | 20565040 | No |
| 3641 | 3623 | 1207.7 | 111.1 | 37.0 | Spirometric reference values from a sample of the general U.S. population. | J L Hankinson, J R Odencrantz, K B Fedan | Am J Respir Crit Care Med | 1999 | 9872837 | Yes |
| 3642 | 2414 | 1207.0 | 85.3 | 42.6 | Quantitative determination of serum triglycerides by the use of enzymes. | G Bucolo, H David | Clin Chem | 1973 | 4703655 | Yes |
| 3643 | 1207 | 1207.0 | 0.0 | 0.0 | Assay of intestinal disaccharidases. | A Dahlqvist | Anal Biochem | 1968 | 5636962 | Yes |
| 3644 | 1207 | 1207.0 | 0.0 | 0.0 | Studies on phosphatidylcholine vesicles. Formation and physical characteristics. | C Huang | Biochemistry | 1969 | 5777332 | Yes |
| 3645 | 1207 | 1207.0 | 29.1 | 29.1 | Anatomy and regulation of the central melanocortin system. | Roger D Cone | Nat Neurosci | 2005 | 15856065 | No |
| 3646 | 1207 | 1207.0 | 56.0 | 56.0 | Root canal irrigants. | Matthias Zehnder | J Endod | 2006 | 16631834 | No |
| 3647 | 2414 | 1207.0 | 52.1 | 26.1 | Defining the role of mTOR in cancer. | David A Guertin, David M Sabatini | Cancer Cell | 2007 | 17613433 | No |
| 3648 | 2413 | 1206.5 | 69.4 | 34.7 | Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. | A Fabiato, F Fabiato | J Physiol (Paris) | 1979 | 533865 | Yes |
| 3649 | 1206 | 1206.0 | 37.4 | 37.4 | Animal mitochondrial DNA: structure and evolution. | D R Wolstenholme | Int Rev Cytol | 1992 | 1452431 | No |
| 3650 | 1206 | 1206.0 | 39.5 | 39.5 | Strategies of antioxidant defense. | H Sies | Eur J Biochem | 1993 | 7688300 | No |
| 3651 | 1206 | 1206.0 | 27.1 | 27.1 | Heterotrimeric G proteins: organizers of transmembrane signals. | E J Neer | Cell | 1995 | 7834744 | No |
| 3652 | 1206 | 1206.0 | 29.4 | 29.4 | Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. | Thomas A Wynn | J Clin Invest | 2007 | 17332879 | No |
| 3653 | 2411 | 1205.5 | 50.8 | 25.4 | Fcgamma receptors as regulators of immune responses. | Falk Nimmerjahn, Jeffrey V Ravetch | Nat Rev Immunol | 2008 | 18064051 | No |
| 3654 | 6026 | 1205.2 | 148.3 | 29.7 | Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. | T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L Coffman | J Immunol | 1986 | 2419430 | Yes |
| 3655 | 1205 | 1205.0 | 30.3 | 30.3 | Aptamers: an emerging class of molecules that rival antibodies in diagnostics. | S D Jayasena | Clin Chem | 1999 | 10471678 | No |
| 3656 | 1205 | 1205.0 | 22.1 | 22.1 | Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. | Eric C Lai | Nat Genet | 2002 | 11896390 | Yes |
| 3657 | 2408 | 1204.0 | 48.9 | 24.4 | Multiple nuclear factors interact with the immunoglobulin enhancer sequences. | R Sen, D Baltimore | Cell | 1986 | 3091258 | Yes |
| 3658 | 1204 | 1204.0 | 45.1 | 45.1 | Predictors of postpartum depression: an update. | C T Beck | Nurs Res | 2001 | 11570712 | Yes |
| 3659 | 1204 | 1204.0 | 0.0 | 0.0 | Preliminary Trial Of Carisoprodol In Multiple Sclerosis. | B Ashworth | Practitioner | 1964 | 14143329 | Yes |
| 3660 | 1204 | 1204.0 | 28.7 | 28.7 | Solid-state nanopores. | Cees Dekker | Nat Nanotechnol | 2007 | 18654264 | No |
| 3661 | 8427 | 1203.9 | 170.8 | 24.4 | Exploration, normalization, and summaries of high density oligonucleotide array probe level data. | Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P Speed | Biostatistics | 2003 | 12925520 | Yes |
| 3662 | 2407 | 1203.5 | 58.3 | 29.1 | Shape-controlled synthesis of gold and silver nanoparticles. | Yugang Sun, Younan Xia | Science | 2002 | 12481134 | Yes |
| 3663 | 2407 | 1203.5 | 55.3 | 27.6 | Next-generation DNA sequencing. | Jay Shendure, Hanlee Ji | Nat Biotechnol | 2008 | 18846087 | Yes |
| 3664 | 2407 | 1203.5 | 63.3 | 31.6 | Targeting hypoxia in cancer therapy. | William R Wilson, Michael P Hay | Nat Rev Cancer | 2011 | 21606941 | No |
| 3665 | 4813 | 1203.2 | 107.0 | 26.8 | Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. | J E Walker, M Saraste, M J Runswick, N J Gay | EMBO J | 1982 | 6329717 | Yes |
| 3666 | 1203 | 1203.0 | 25.3 | 25.3 | MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. | R N Germain | Cell | 1994 | 8293464 | No |
| 3667 | 2406 | 1203.0 | 63.0 | 31.5 | The protective effects of estrogen on the cardiovascular system. | M E Mendelsohn, R H Karas | N Engl J Med | 1999 | 10362825 | No |
| 3668 | 1203 | 1203.0 | 23.6 | 23.6 | Microarray data normalization and transformation. | John Quackenbush | Nat Genet | 2002 | 12454644 | No |
| 3669 | 1202 | 1202.0 | 19.7 | 19.7 | Evolution and tinkering. | F Jacob | Science | 1977 | 860134 | Yes |
| 3670 | 1202 | 1202.0 | 38.3 | 38.3 | Biosynthesis and metabolism of endothelium-derived nitric oxide. | L J Ignarro | Annu Rev Pharmacol Toxicol | 1990 | 2188578 | No |
| 3671 | 1202 | 1202.0 | 30.7 | 30.7 | Hereditary cancer, oncogenes, and antioncogenes. | A G Knudson | Cancer Res | 1985 | 2983882 | Yes |
| 3672 | 1202 | 1202.0 | 22.0 | 22.0 | Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. | D Hanahan | Nature | 1985 | 2986015 | Yes |
| 3673 | 1202 | 1202.0 | 42.0 | 42.0 | Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. | H V Gelboin | Physiol Rev | 1980 | 7001511 | No |
| 3674 | 1202 | 1202.0 | 47.1 | 47.1 | Methods for dealing with reaction time outliers. | R Ratcliff | Psychol Bull | 1993 | 8272468 | Yes |
| 3675 | 2404 | 1202.0 | 59.7 | 29.9 | Efficient behavior of small-world networks. | V Latora, M Marchiori | Phys Rev Lett | 2001 | 11690461 | Yes |
| 3676 | 2403 | 1201.5 | 65.4 | 32.7 | The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. | Laetitia Prut, Catherine Belzung | Eur J Pharmacol | 2003 | 12600700 | No |
| 3677 | 2403 | 1201.5 | 54.4 | 27.2 | Esophageal cancer. | Peter C Enzinger, Robert J Mayer | N Engl J Med | 2003 | 14657432 | No |
| 3678 | 2403 | 1201.5 | 64.4 | 32.2 | Anemia of chronic disease. | Guenter Weiss, Lawrence T Goodnough | N Engl J Med | 2005 | 15758012 | No |
| 3679 | 1201 | 1201.0 | 40.2 | 40.2 | The pathogenesis of sepsis. | R C Bone | Ann Intern Med | 1991 | 1872494 | No |
| 3680 | 1201 | 1201.0 | 56.1 | 56.1 | Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. | M Rutter | Br J Psychiatry | 1985 | 3830321 | Yes |
| 3681 | 1201 | 1201.0 | 33.1 | 33.1 | Descending pathways in motor control. | Roger N Lemon | Annu Rev Neurosci | 2008 | 18558853 | No |
| 3682 | 10805 | 1200.6 | 362.0 | 40.2 | A novel potent vasoconstrictor peptide produced by vascular endothelial cells. | M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T Masaki | Nature | 1988 | 2451132 | Yes |
| 3683 | 2400 | 1200.0 | 54.9 | 27.4 | Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. | J D McGhee, P H Von Hippel | J Mol Biol | 1974 | 4416620 | Yes |
| 3684 | 1200 | 1200.0 | 35.4 | 35.4 | Pharmacology of cannabinoid CB1 and CB2 receptors. | R G Pertwee | Pharmacol Ther | 1997 | 9336020 | No |
| 3685 | 1200 | 1200.0 | 39.5 | 39.5 | Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. | M Leavitt | MedGenMed | 2001 | 11549951 | No |
| 3686 | 1200 | 1200.0 | 23.5 | 23.5 | IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. | Yong-Jun Liu | Annu Rev Immunol | 2005 | 15771572 | No |
| 3687 | 1200 | 1200.0 | 55.1 | 55.1 | Reference methods for the assessment of physical characteristics of meat. | K O Honikel | Meat Sci | 1998 | 22060626 | Yes |
| 3688 | 1200 | 1200.0 | 34.4 | 34.4 | Regulation of immune responses by prostaglandin E2. | Pawel Kalinski | J Immunol | 2012 | 22187483 | No |
| 3689 | 1200 | 1200.0 | 40.9 | 40.9 | Supramolecular binding thermodynamics by dispersion-corrected density functional theory. | Stefan Grimme | Chemistry | 2012 | 22782805 | Yes |
| 3690 | 1200 | 1200.0 | 31.4 | 31.4 | The complex world of WNT receptor signalling. | Christof Niehrs | Nat Rev Mol Cell Biol | 2012 | 23151663 | No |
| 3691 | 2400 | 1200.0 | 90.9 | 45.5 | The blood-brain barrier. | Richard Daneman, Alexandre Prat | Cold Spring Harb Perspect Biol | 2015 | 25561720 | No |
| 3692 | 1199 | 1199.0 | 34.9 | 34.9 | Determinants of tumor blood flow: a review. | R K Jain | Cancer Res | 1988 | 3282647 | No |
| 3693 | 1199 | 1199.0 | 41.1 | 41.1 | Recommended effect size statistics for repeated measures designs. | Roger Bakeman | Behav Res Methods | 2005 | 16405133 | Yes |
| 3694 | 2398 | 1199.0 | 63.0 | 31.5 | Sterile inflammation: sensing and reacting to damage. | Grace Y Chen, Gabriel Nunez | Nat Rev Immunol | 2010 | 21088683 | No |
| 3695 | 1199 | 1199.0 | 43.1 | 43.1 | Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning. | Gyorgy Buzsaki | Hippocampus | 2015 | 26135716 | No |
| 3696 | 1198 | 1198.0 | 39.8 | 39.8 | An approach for the treatment of penile carcinoma. | R M Cabanas | Cancer | 1977 | 837331 | Yes |
| 3697 | 2396 | 1198.0 | 167.8 | 83.9 | Radiological demarcation of cemented sockets in total hip replacement. | J G DeLee, J Charnley | Clin Orthop Relat Res | 1976 | 991504 | Yes |
| 3698 | 1198 | 1198.0 | 54.7 | 54.7 | Psychedelics. | David E Nichols | Pharmacol Rev | 2016 | 26841800 | No |
| 3699 | 2395 | 1197.5 | 62.1 | 31.1 | An improved general amino acid replacement matrix. | Si Quang Le, Olivier Gascuel | Mol Biol Evol | 2008 | 18367465 | Yes |
| 3700 | 2395 | 1197.5 | 89.3 | 44.6 | Loneliness matters: a theoretical and empirical review of consequences and mechanisms. | Louise C Hawkley, John T Cacioppo | Ann Behav Med | 2010 | 20652462 | No |
| 3701 | 4789 | 1197.2 | 117.8 | 29.4 | Base-calling of automated sequencer traces using phred. I. Accuracy assessment. | B Ewing, L Hillier, M C Wendl, P Green | Genome Res | 1998 | 9521921 | Yes |
| 3702 | 1197 | 1197.0 | 29.0 | 29.0 | Rapid and sensitive sequence comparison with FASTP and FASTA. | W R Pearson | Methods Enzymol | 1990 | 2156132 | Yes |
| 3703 | 1197 | 1197.0 | 31.9 | 31.9 | Pathogenesis of dengue: challenges to molecular biology. | S B Halstead | Science | 1988 | 3277268 | No |
| 3704 | 2394 | 1197.0 | 89.1 | 44.5 | The Modified Mini-Mental State (3MS) examination. | E L Teng, H C Chui | J Clin Psychiatry | 1987 | 3611032 | Yes |
| 3705 | 1197 | 1197.0 | 38.3 | 38.3 | Low-molecular-weight heparins. | J I Weitz | N Engl J Med | 1997 | 9278467 | No |
| 3706 | 3591 | 1197.0 | 76.6 | 25.5 | Cellular survival: a play in three Akts. | S R Datta, A Brunet, M E Greenberg | Genes Dev | 1999 | 10579998 | No |
| 3707 | 2394 | 1197.0 | 92.4 | 46.2 | Pharmaceuticals and personal care products in the environment: agents of subtle change? | C G Daughton, T A Ternes | Environ Health Perspect | 1999 | 10592150 | No |
| 3708 | 1197 | 1197.0 | 26.8 | 26.8 | Molecular imaging of cancer with positron emission tomography. | Sanjiv Sam Gambhir | Nat Rev Cancer | 2002 | 12209157 | No |
| 3709 | 1197 | 1197.0 | 0.0 | 0.0 | The powerful placebo. | H K Beecher | J Am Med Assoc | 1955 | 13271123 | Yes |
| 3710 | 1197 | 1197.0 | 35.0 | 35.0 | Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. | Barry Halliwell | Plant Physiol | 2006 | 16760481 | Yes |
| 3711 | 2394 | 1197.0 | 86.2 | 43.1 | Required sample size to detect the mediated effect. | Matthew S Fritz, David P MacKinnon | Psychol Sci | 2007 | 17444920 | Yes |
| 3712 | 1197 | 1197.0 | 26.7 | 26.7 | The action potential in mammalian central neurons. | Bruce P Bean | Nat Rev Neurosci | 2007 | 17514198 | No |
| 3713 | 3590 | 1196.7 | 85.3 | 28.4 | STATs in cancer inflammation and immunity: a leading role for STAT3. | Hua Yu, Drew Pardoll, Richard Jove | Nat Rev Cancer | 2009 | 19851315 | No |
| 3714 | 1196 | 1196.0 | 0.0 | 0.0 | Pathologic anatomy of the pancreas in juvenile diabetes mellitus. | W Gepts | Diabetes | 1965 | 5318831 | Yes |
| 3715 | 1195 | 1195.0 | 41.0 | 41.0 | Spatially heterogeneous dynamics in supercooled liquids. | M D Ediger | Annu Rev Phys Chem | 2000 | 11031277 | Yes |
| 3716 | 1195 | 1195.0 | 35.2 | 35.2 | Disseminating innovations in health care. | Donald M Berwick | JAMA | 2003 | 12697800 | Yes |
| 3717 | 2389 | 1194.5 | 55.9 | 27.9 | Effect of pegylation on pharmaceuticals. | J Milton Harris, Robert B Chess | Nat Rev Drug Discov | 2003 | 12612647 | No |
| 3718 | 1194 | 1194.0 | 55.7 | 55.7 | Analysis of Fickian and non-Fickian drug release from polymers. | N A Peppas | Pharm Acta Helv | 1985 | 4011621 | Yes |
| 3719 | 2388 | 1194.0 | 98.2 | 49.1 | Rapid procedure for detection and isolation of large and small plasmids. | C I Kado, S T Liu | J Bacteriol | 1981 | 7009583 | Yes |
| 3720 | 1194 | 1194.0 | 41.2 | 41.2 | The patient-physician relationship. Narrative medicine: a model for empathy, reflection, profession, and trust. | R Charon | JAMA | 2001 | 11597295 | Yes |
| 3721 | 1194 | 1194.0 | 28.0 | 28.0 | Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. | Michael J Sanderson | Mol Biol Evol | 2002 | 11752195 | Yes |
| 3722 | 2388 | 1194.0 | 54.7 | 27.4 | Modes of resistance to anti-angiogenic therapy. | Gabriele Bergers, Douglas Hanahan | Nat Rev Cancer | 2008 | 18650835 | No |
| 3723 | 1194 | 1194.0 | 0.0 | 0.0 | Histological demonstration of mucin after periodic acid. | J F A McMANUS | Nature | 1946 | 20995486 | Yes |
| 3724 | 4774 | 1193.5 | 95.8 | 23.9 | Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. | L Alexopoulou, A C Holt, R Medzhitov, R A Flavell | Nature | 2001 | 11607032 | Yes |
| 3725 | 3580 | 1193.3 | 82.4 | 27.5 | Hepatocellular carcinoma. | Josep M Llovet, Andrew Burroughs, Jordi Bruix | Lancet | 2003 | 14667750 | No |
| 3726 | 1193 | 1193.0 | 54.0 | 54.0 | Nontuberculous mycobacteria and associated diseases. | E Wolinsky | Am Rev Respir Dis | 1979 | 369415 | No |
| 3727 | 2386 | 1193.0 | 63.6 | 31.8 | The evolution of cooperation. | R Axelrod, W D Hamilton | Science | 1981 | 7466396 | Yes |
| 3728 | 1193 | 1193.0 | 0.0 | 0.0 | The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. | W G Duncombe | Clin Chim Acta | 1964 | 14122498 | Yes |
| 3729 | 2385 | 1192.5 | 89.6 | 44.8 | Mechanisms of hepatic stellate cell activation. | Takuma Tsuchida, Scott L Friedman | Nat Rev Gastroenterol Hepatol | 2017 | 28487545 | No |
| 3730 | 3576 | 1192.0 | 93.5 | 31.2 | Pathogenic Escherichia coli. | James B Kaper, James P Nataro, Harry L Mobley | Nat Rev Microbiol | 2004 | 15040260 | No |
| 3731 | 2383 | 1191.5 | 60.2 | 30.1 | Using RepeatMasker to identify repetitive elements in genomic sequences. | Maja Tarailo-Graovac, Nansheng Chen | Curr Protoc Bioinformatics | 2009 | 19274634 | Yes |
| 3732 | 3574 | 1191.3 | 144.5 | 48.2 | Concurrent and predictive validity of a self-reported measure of medication adherence. | D E Morisky, L W Green, D M Levine | Med Care | 1986 | 3945130 | Yes |
| 3733 | 1191 | 1191.0 | 0.0 | 0.0 | Mechanisms of lipid peroxide formation in animal tissues. | E D Wills | Biochem J | 1966 | 5964963 | Yes |
| 3734 | 1191 | 1191.0 | 22.5 | 22.5 | The power and the promise of DNA methylation markers. | Peter W Laird | Nat Rev Cancer | 2003 | 12671664 | No |
| 3735 | 1190 | 1190.0 | 29.3 | 29.3 | The prefrontal cortex--an update: time is of the essence. | J M Fuster | Neuron | 2001 | 11394996 | No |
| 3736 | 2379 | 1189.5 | 68.9 | 34.5 | Mental rotation of three-dimensional objects. | R N Shepard, J Metzler | Science | 1971 | 5540314 | Yes |
| 3737 | 2379 | 1189.5 | 59.8 | 29.9 | Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation. | Ivica Letunic, Peer Bork | Bioinformatics | 2007 | 17050570 | Yes |
| 3738 | 1189 | 1189.0 | 37.8 | 37.8 | Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. | P S Tofts | J Magn Reson Imaging | 1997 | 9039598 | No |
| 3739 | 2378 | 1189.0 | 53.4 | 26.7 | Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. | Daniel J Hicklin, Lee M Ellis | J Clin Oncol | 2005 | 15585754 | No |
| 3740 | 2378 | 1189.0 | 51.6 | 25.8 | Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. | Javier A Menendez, Ruth Lupu | Nat Rev Cancer | 2007 | 17882277 | No |
| 3741 | 1189 | 1189.0 | 27.1 | 27.1 | The impact of next-generation sequencing technology on genetics. | Elaine R Mardis | Trends Genet | 2008 | 18262675 | No |
| 3742 | 1189 | 1189.0 | 39.3 | 39.3 | Biomedical photoacoustic imaging. | Paul Beard | Interface Focus | 2011 | 22866233 | Yes |
| 3743 | 16635 | 1188.2 | 371.1 | 26.5 | Crystallography & NMR system: A new software suite for macromolecular structure determination. | A T Brunger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L Warren | Acta Crystallogr D Biol Crystallogr | 1998 | 9757107 | Yes |
| 3744 | 1188 | 1188.0 | 31.1 | 31.1 | Soil carbon sequestration impacts on global climate change and food security. | R Lal | Science | 2004 | 15192216 | Yes |
| 3745 | 1188 | 1188.0 | 23.8 | 23.8 | Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. | Mats G L Gustafsson | Proc Natl Acad Sci U S A | 2005 | 16141335 | Yes |
| 3746 | 1188 | 1188.0 | 44.5 | 44.5 | Surface-enhanced Raman spectroscopy: concepts and chemical applications. | Sebastian Schlucker | Angew Chem Int Ed Engl | 2014 | 24711218 | Yes |
| 3747 | 1188 | 1188.0 | 78.6 | 78.6 | Antimicrobial Resistance: Implications and Costs. | Porooshat Dadgostar | Infect Drug Resist | 2019 | 31908502 | No |
| 3748 | 5939 | 1187.8 | 200.8 | 40.2 | Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. | D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L Witztum | N Engl J Med | 1989 | 2648148 | No |
| 3749 | 2375 | 1187.5 | 72.4 | 36.2 | Solubilization of membranes by detergents. | A Helenius, K Simons | Biochim Biophys Acta | 1975 | 1091302 | No |
| 3750 | 4749 | 1187.2 | 206.7 | 51.7 | Development of recommendations for SEMG sensors and sensor placement procedures. | H J Hermens, B Freriks, C Disselhorst-Klug, G Rau | J Electromyogr Kinesiol | 2000 | 11018445 | Yes |
| 3751 | 1187 | 1187.0 | 38.0 | 38.0 | Molecular biology of steroid hormone synthesis. | W L Miller | Endocr Rev | 1988 | 3061784 | No |
| 3752 | 1187 | 1187.0 | 34.4 | 34.4 | Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. | F P Guengerich | Chem Res Toxicol | 2001 | 11409933 | No |
| 3753 | 1187 | 1187.0 | 25.5 | 25.5 | Osmotic stress signaling and osmoadaptation in yeasts. | Stefan Hohmann | Microbiol Mol Biol Rev | 2002 | 12040128 | No |
| 3754 | 2374 | 1187.0 | 54.8 | 27.4 | Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. | Sharon R Browning, Brian L Browning | Am J Hum Genet | 2007 | 17924348 | Yes |
| 3755 | 1187 | 1187.0 | 25.3 | 25.3 | Version 1.2 of the Crystallography and NMR system. | Axel T Brunger | Nat Protoc | 2007 | 18007608 | Yes |
| 3756 | 1187 | 1187.0 | 36.8 | 36.8 | The social brain in adolescence. | Sarah-Jayne Blakemore | Nat Rev Neurosci | 2008 | 18354399 | No |
| 3757 | 3561 | 1187.0 | 111.6 | 37.2 | DNA methylation and its basic function. | Lisa D Moore, Thuc Le, Guoping Fan | Neuropsychopharmacology | 2013 | 22781841 | No |
| 3758 | 3559 | 1186.3 | 73.1 | 24.4 | Predicting coiled coils from protein sequences. | A Lupas, M Van Dyke, J Stock | Science | 1991 | 2031185 | Yes |
| 3759 | 1186 | 1186.0 | 60.9 | 60.9 | Clinical experience with impedance audiometry. | J Jerger | Arch Otolaryngol | 1970 | 5455571 | Yes |
| 3760 | 1186 | 1186.0 | 27.1 | 27.1 | Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. | Ferric C Fang | Nat Rev Microbiol | 2004 | 15378046 | No |
| 3761 | 1186 | 1186.0 | 33.3 | 33.3 | Voltage-gated calcium channels. | William A Catterall | Cold Spring Harb Perspect Biol | 2011 | 21746798 | No |
| 3762 | 1186 | 1186.0 | 52.8 | 52.8 | Fibromyalgia: a clinical review. | Daniel J Clauw | JAMA | 2014 | 24737367 | No |
| 3763 | 5929 | 1185.8 | 124.5 | 24.9 | Electrostatics of nanosystems: application to microtubules and the ribosome. | N A Baker, D Sept, S Joseph, M J Holst, J A McCammon | Proc Natl Acad Sci U S A | 2001 | 11517324 | Yes |
| 3764 | 3557 | 1185.7 | 202.7 | 67.6 | Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles. | Aldenor G Santos, Gisele O Da Rocha, Jailson B De Andrade | Sci Rep | 2019 | 30626917 | Yes |
| 3765 | 4742 | 1185.5 | 132.5 | 33.1 | A role for mitochondria in NLRP3 inflammasome activation. | Rongbin Zhou, Amir S Yazdi, Philippe Menu, Jurg Tschopp | Nature | 2011 | 21124315 | Yes |
| 3766 | 2370 | 1185.0 | 110.2 | 55.1 | Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. | J D Peuler, G A Johnson | Life Sci | 1977 | 904439 | Yes |
| 3767 | 1185 | 1185.0 | 40.7 | 40.7 | Interleukin-1 and the pathogenesis of the acute-phase response. | C A Dinarello | N Engl J Med | 1984 | 6208485 | No |
| 3768 | 1185 | 1185.0 | 41.4 | 41.4 | Selective attention and the organization of visual information. | J Duncan | J Exp Psychol Gen | 1984 | 6240521 | Yes |
| 3769 | 1185 | 1185.0 | 30.3 | 30.3 | Quantification of beta-sheet amyloid fibril structures with thioflavin T. | H LeVine | Methods Enzymol | 1999 | 10507030 | Yes |
| 3770 | 1185 | 1185.0 | 37.7 | 37.7 | Critical evaluation of energy intake using the Goldberg cut-off for energy intake:basal metabolic rate. A practical guide to its calculation, use and limitations. | A E Black | Int J Obes Relat Metab Disord | 2000 | 11033980 | Yes |
| 3771 | 1185 | 1185.0 | 32.1 | 32.1 | Physiology and immunology of the cholinergic antiinflammatory pathway. | Kevin J Tracey | J Clin Invest | 2007 | 17273548 | No |
| 3772 | 1185 | 1185.0 | 37.2 | 37.2 | Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. | Bruce S McEwen | Eur J Pharmacol | 2008 | 18282566 | No |
| 3773 | 1185 | 1185.0 | 46.0 | 46.0 | Fiber and prebiotics: mechanisms and health benefits. | Joanne Slavin | Nutrients | 2013 | 23609775 | No |
| 3774 | 21320 | 1184.4 | 535.6 | 29.8 | PHENIX: a comprehensive Python-based system for macromolecular structure solution. | Paul D Adams, Pavel V Afonine, Gabor Bunkoczi, Vincent B Chen, Ian W Davis, Nathaniel Echols, Jeffrey J Headd, Li-Wei Hung, Gary J Kapral, Ralf W Grosse-Kunstleve, Airlie J McCoy, Nigel W Moriarty, Robert Oeffner, Randy J Read, David C Richardson, Jane S Richardson, Thomas C Terwilliger, Peter H Zwart | Acta Crystallogr D Biol Crystallogr | 2010 | 20124702 | Yes |
| 3775 | 2368 | 1184.0 | 92.1 | 46.0 | Positive psychology. An introduction. | M E Seligman, M Csikszentmihalyi | Am Psychol | 2000 | 11392865 | Yes |
| 3776 | 1184 | 1184.0 | 37.6 | 37.6 | Distracted and confused?: selective attention under load. | Nilli Lavie | Trends Cogn Sci | 2005 | 15668100 | No |
| 3777 | 4735 | 1183.8 | 109.7 | 27.4 | Isolation and characterization of exosomes from cell culture supernatants and biological fluids. | Clotilde Thery, Sebastian Amigorena, Graca Raposo, Aled Clayton | Curr Protoc Cell Biol | 2006 | 18228490 | Yes |
| 3778 | 2367 | 1183.5 | 52.3 | 26.1 | Functions of lipid rafts in biological membranes. | D A Brown, E London | Annu Rev Cell Dev Biol | 1998 | 9891780 | No |
| 3779 | 2367 | 1183.5 | 50.9 | 25.4 | Genomic control for association studies. | B Devlin, K Roeder | Biometrics | 1999 | 11315092 | Yes |
| 3780 | 1183 | 1183.0 | 0.0 | 0.0 | The Stability of Broken Ends of Chromosomes in Zea Mays. | B McClintock | Genetics | 1941 | 17247004 | Yes |
| 3781 | 3549 | 1183.0 | 90.5 | 30.2 | In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. | Chun-Chi Liang, Ann Y Park, Jun-Lin Guan | Nat Protoc | 2007 | 17406593 | Yes |
| 3782 | 5913 | 1182.6 | 164.1 | 32.8 | A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? | Leonardo Salmena, Laura Poliseno, Yvonne Tay, Lev Kats, Pier Paolo Pandolfi | Cell | 2011 | 21802130 | Yes |
| 3783 | 2365 | 1182.5 | 60.8 | 30.4 | The neural basis of decision making. | Joshua I Gold, Michael N Shadlen | Annu Rev Neurosci | 2007 | 17600525 | No |
| 3784 | 2365 | 1182.5 | 100.8 | 50.4 | The social determinants of health: it's time to consider the causes of the causes. | Paula Braveman, Laura Gottlieb | Public Health Rep | 2014 | 24385661 | No |
| 3785 | 1182 | 1182.0 | 33.6 | 33.6 | Interval estimation for the difference between independent proportions: comparison of eleven methods. | R G Newcombe | Stat Med | 1998 | 9595617 | Yes |
| 3786 | 1182 | 1182.0 | 0.0 | 0.0 | A new microscopic principle. | D Gabor | Nature | 1948 | 18860291 | Yes |
| 3787 | 2364 | 1182.0 | 88.3 | 44.1 | NAFLD: a multisystem disease. | Christopher D Byrne, Giovanni Targher | J Hepatol | 2015 | 25920090 | No |
| 3788 | 3546 | 1182.0 | 238.2 | 79.4 | Estimating psychological networks and their accuracy: A tutorial paper. | Sacha Epskamp, Denny Borsboom, Eiko I Fried | Behav Res Methods | 2018 | 28342071 | Yes |
| 3789 | 2363 | 1181.5 | 63.8 | 31.9 | The low-density lipoprotein pathway and its relation to atherosclerosis. | J L Goldstein, M S Brown | Annu Rev Biochem | 1977 | 197883 | No |
| 3790 | 1181 | 1181.0 | 31.3 | 31.3 | Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. | Mark E Bouton | Biol Psychiatry | 2002 | 12437938 | No |
| 3791 | 1181 | 1181.0 | 30.9 | 30.9 | The role of acetylcholine in learning and memory. | Michael E Hasselmo | Curr Opin Neurobiol | 2006 | 17011181 | No |
| 3792 | 2361 | 1180.5 | 77.3 | 38.6 | Intestinal epithelial cells: regulators of barrier function and immune homeostasis. | Lance W Peterson, David Artis | Nat Rev Immunol | 2014 | 24566914 | No |
| 3793 | 1180 | 1180.0 | 27.3 | 27.3 | Hybridization of denatured RNA transferred or dotted nitrocellulose paper. | P S Thomas | Methods Enzymol | 1983 | 6194404 | Yes |
| 3794 | 7080 | 1180.0 | 192.0 | 32.0 | The capsaicin receptor: a heat-activated ion channel in the pain pathway. | M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D Julius | Nature | 1997 | 9349813 | Yes |
| 3795 | 1180 | 1180.0 | 43.5 | 43.5 | Mental illness and/or mental health? Investigating axioms of the complete state model of health. | Corey L M Keyes | J Consult Clin Psychol | 2005 | 15982151 | Yes |
| 3796 | 5900 | 1180.0 | 219.1 | 43.8 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman, | Open Med | 2009 | 21603045 | Yes |
| 3797 | 2359 | 1179.5 | 45.8 | 22.9 | Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. | C Li, W H Wong | Proc Natl Acad Sci U S A | 2001 | 11134512 | Yes |
| 3798 | 2358 | 1179.0 | 44.4 | 22.2 | AP-1 as a regulator of cell life and death. | Eitan Shaulian, Michael Karin | Nat Cell Biol | 2002 | 11988758 | No |
| 3799 | 1179 | 1179.0 | 35.6 | 35.6 | A perspective on judgment and choice: mapping bounded rationality. | Daniel Kahneman | Am Psychol | 2003 | 14584987 | No |
| 3800 | 1179 | 1179.0 | 48.6 | 48.6 | Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance. | Philip C Calder | Biochim Biophys Acta | 2015 | 25149823 | No |
| 3801 | 7070 | 1178.3 | 620.1 | 103.4 | ColabFold: making protein folding accessible to all. | Milot Mirdita, Konstantin Schutze, Yoshitaka Moriwaki, Lim Heo, Sergey Ovchinnikov, Martin Steinegger | Nat Methods | 2022 | 35637307 | Yes |
| 3802 | 1178 | 1178.0 | 0.0 | 0.0 | Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. | J Altman | J Comp Neurol | 1969 | 5361244 | Yes |
| 3803 | 1178 | 1178.0 | 35.4 | 35.4 | Venous thrombosis: a multicausal disease. | F R Rosendaal | Lancet | 1999 | 10209995 | No |
| 3804 | 2356 | 1178.0 | 75.0 | 37.5 | Extended-spectrum beta-lactamases: a clinical update. | David L Paterson, Robert A Bonomo | Clin Microbiol Rev | 2005 | 16223952 | No |
| 3805 | 1178 | 1178.0 | 26.3 | 26.3 | Pyramidal neurons: dendritic structure and synaptic integration. | Nelson Spruston | Nat Rev Neurosci | 2008 | 18270515 | No |
| 3806 | 1178 | 1178.0 | 49.8 | 49.8 | The epidemiology and impact of pain in osteoarthritis. | T Neogi | Osteoarthritis Cartilage | 2013 | 23973124 | Yes |
| 3807 | 7064 | 1177.3 | 230.9 | 38.5 | Open Babel: An open chemical toolbox. | Noel M O'Boyle, Michael Banck, Craig A James, Chris Morley, Tim Vandermeersch, Geoffrey R Hutchison | J Cheminform | 2011 | 21982300 | Yes |
| 3808 | 1177 | 1177.0 | 38.3 | 38.3 | Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. | P J Basser | NMR Biomed | 1995 | 8739270 | No |
| 3809 | 1177 | 1177.0 | 32.3 | 32.3 | Electrogenerated chemiluminescence and its biorelated applications. | Wujian Miao | Chem Rev | 2008 | 18505298 | No |
| 3810 | 4707 | 1176.8 | 147.5 | 36.9 | Causal analysis approaches in Ingenuity Pathway Analysis. | Andreas Kramer, Jeff Green, Jack Pollard, Stuart Tugendreich | Bioinformatics | 2014 | 24336805 | Yes |
| 3811 | 4705 | 1176.2 | 122.7 | 30.7 | C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. | P M Ridker, C H Hennekens, J E Buring, N Rifai | N Engl J Med | 2000 | 10733371 | Yes |
| 3812 | 1176 | 1176.0 | 25.1 | 25.1 | Molecular cloning and expression of glycogen synthase kinase-3/factor A. | J R Woodgett | EMBO J | 1990 | 2164470 | Yes |
| 3813 | 1176 | 1176.0 | 26.6 | 26.6 | Cadherins: a molecular family important in selective cell-cell adhesion. | M Takeichi | Annu Rev Biochem | 1990 | 2197976 | No |
| 3814 | 2352 | 1176.0 | 71.3 | 35.6 | Excitatory amino acids as a final common pathway for neurologic disorders. | S A Lipton, P A Rosenberg | N Engl J Med | 1994 | 7905600 | No |
| 3815 | 2352 | 1176.0 | 56.2 | 28.1 | A note on quantifying follow-up in studies of failure time. | M Schemper, T L Smith | Control Clin Trials | 1996 | 8889347 | Yes |
| 3816 | 1176 | 1176.0 | 23.4 | 23.4 | The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. | Y Yarden | Eur J Cancer | 2001 | 11597398 | No |
| 3817 | 2352 | 1176.0 | 78.3 | 39.1 | Shaping functional architecture by oscillatory alpha activity: gating by inhibition. | Ole Jensen, Ali Mazaheri | Front Hum Neurosci | 2010 | 21119777 | Yes |
| 3818 | 2351 | 1175.5 | 71.4 | 35.7 | Neural regulation of endocrine and autonomic stress responses. | Yvonne M Ulrich-Lai, James P Herman | Nat Rev Neurosci | 2009 | 19469025 | No |
| 3819 | 2350 | 1175.0 | 104.1 | 52.0 | The aggression questionnaire. | A H Buss, M Perry | J Pers Soc Psychol | 1992 | 1403624 | Yes |
| 3820 | 1175 | 1175.0 | 0.0 | 0.0 | The cytoarchitectonic organization of the spinal cord in the cat. | B Rexed | J Comp Neurol | 1952 | 14946260 | Yes |
| 3821 | 1175 | 1175.0 | 26.6 | 26.6 | Liver regeneration. | George K Michalopoulos | J Cell Physiol | 2007 | 17559071 | No |
| 3822 | 2349 | 1174.5 | 53.2 | 26.6 | Synaptic activity and the construction of cortical circuits. | L C Katz, C J Shatz | Science | 1996 | 8895456 | No |
| 3823 | 7046 | 1174.3 | 216.7 | 36.1 | Mild cognitive impairment: clinical characterization and outcome. | R C Petersen, G E Smith, S C Waring, R J Ivnik, E G Tangalos, E Kokmen | Arch Neurol | 1999 | 10190820 | Yes |
| 3824 | 7045 | 1174.2 | 197.1 | 32.9 | Prediction of coronary heart disease using risk factor categories. | P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B Kannel | Circulation | 1998 | 9603539 | Yes |
| 3825 | 1174 | 1174.0 | 46.1 | 46.1 | Omega-3 fatty acids in health and disease and in growth and development. | A P Simopoulos | Am J Clin Nutr | 1991 | 1908631 | No |
| 3826 | 1174 | 1174.0 | 46.2 | 46.2 | Presynaptic regulation of catecholamine release. | S Z Langer | Biochem Pharmacol | 1974 | 4617579 | No |
| 3827 | 1174 | 1174.0 | 52.8 | 52.8 | Gait changes in older adults: predictors of falls or indicators of fear. | B E Maki | J Am Geriatr Soc | 1997 | 9063277 | Yes |
| 3828 | 1174 | 1174.0 | 41.9 | 41.9 | Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. | Ronald A Hites | Environ Sci Technol | 2004 | 14998004 | Yes |
| 3829 | 2347 | 1173.5 | 72.2 | 36.1 | Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. | R J Ginsberg, L V Rubinstein | Ann Thorac Surg | 1995 | 7677489 | Yes |
| 3830 | 4694 | 1173.5 | 151.7 | 37.9 | Biomolecular condensates: organizers of cellular biochemistry. | Salman F Banani, Hyun O Lee, Anthony A Hyman, Michael K Rosen | Nat Rev Mol Cell Biol | 2017 | 28225081 | No |
| 3831 | 3519 | 1173.0 | 109.1 | 36.4 | Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. | A DeLean, P J Munson, D Rodbard | Am J Physiol | 1978 | 686171 | Yes |
| 3832 | 1173 | 1173.0 | 21.6 | 21.6 | DNA methylation in cancer: too much, but also too little. | Melanie Ehrlich | Oncogene | 2002 | 12154403 | No |
| 3833 | 1173 | 1173.0 | 30.0 | 30.0 | Metagenomics: application of genomics to uncultured microorganisms. | Jo Handelsman | Microbiol Mol Biol Rev | 2004 | 15590779 | No |
| 3834 | 1173 | 1173.0 | 44.8 | 44.8 | Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world. | Murray B Isman | Annu Rev Entomol | 2006 | 16332203 | No |
| 3835 | 1173 | 1173.0 | 45.7 | 45.7 | Cancer-related fatigue--mechanisms, risk factors, and treatments. | Julienne E Bower | Nat Rev Clin Oncol | 2014 | 25113839 | No |
| 3836 | 3518 | 1172.7 | 154.1 | 51.4 | Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. | Neil M Davies, Michael V Holmes, George Davey Smith | BMJ | 2018 | 30002074 | Yes |
| 3837 | 2345 | 1172.5 | 90.4 | 45.2 | Perceived discrimination and health: a meta-analytic review. | Elizabeth A Pascoe, Laura Smart Richman | Psychol Bull | 2009 | 19586161 | Yes |
| 3838 | 1172 | 1172.0 | 48.6 | 48.6 | Presynaptic regulation of the release of catecholamines. | S Z Langer | Pharmacol Rev | 1980 | 6267618 | Yes |
| 3839 | 1172 | 1172.0 | 28.6 | 28.6 | Amyloid, the presenilins and Alzheimer's disease. | J Hardy | Trends Neurosci | 1997 | 9106355 | No |
| 3840 | 1172 | 1172.0 | 26.6 | 26.6 | Toward self-organization and complex matter. | Jean-Marie Lehn | Science | 2002 | 11923524 | Yes |
| 3841 | 1172 | 1172.0 | 0.0 | 0.0 | The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume. | C D Murray | Proc Natl Acad Sci U S A | 1926 | 16576980 | Yes |
| 3842 | 2343 | 1171.5 | 83.7 | 41.9 | Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. | A E Czeizel, I Dudas | N Engl J Med | 1992 | 1307234 | Yes |
| 3843 | 3514 | 1171.3 | 102.1 | 34.0 | Depression: a new animal model sensitive to antidepressant treatments. | R D Porsolt, M Le Pichon, M Jalfre | Nature | 1977 | 559941 | Yes |
| 3844 | 1171 | 1171.0 | 43.6 | 43.6 | Socioeconomic disadvantage and child development. | V C McLoyd | Am Psychol | 1998 | 9491747 | No |
| 3845 | 1171 | 1171.0 | 45.0 | 45.0 | A measure of anxiety symptoms among children. | S H Spence | Behav Res Ther | 1998 | 9648330 | Yes |
| 3846 | 1171 | 1171.0 | 22.2 | 22.2 | The ubiquitin-proteasome pathway: on protein death and cell life. | A Ciechanover | EMBO J | 1998 | 9857172 | No |
| 3847 | 1171 | 1171.0 | 25.4 | 25.4 | The mitochondrial genome: structure, transcription, translation and replication. | J W Taanman | Biochim Biophys Acta | 1999 | 10076021 | No |
| 3848 | 2342 | 1171.0 | 68.5 | 34.2 | Collagen structure and stability. | Matthew D Shoulders, Ronald T Raines | Annu Rev Biochem | 2009 | 19344236 | No |
| 3849 | 2342 | 1171.0 | 79.7 | 39.9 | Microbial interactions: from networks to models. | Karoline Faust, Jeroen Raes | Nat Rev Microbiol | 2012 | 22796884 | No |
| 3850 | 1170 | 1170.0 | 35.8 | 35.8 | Effect of anoxia on ion distribution in the brain. | A J Hansen | Physiol Rev | 1985 | 3880896 | No |
| 3851 | 1170 | 1170.0 | 0.0 | 0.0 | Knee joint changes after meniscectomy. | T J Fairbank | J Bone Joint Surg Br | 1948 | 18894618 | Yes |
| 3852 | 2339 | 1169.5 | 48.7 | 24.4 | Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. | P E Wright, H J Dyson | J Mol Biol | 1999 | 10550212 | No |
| 3853 | 2338 | 1169.0 | 74.9 | 37.5 | Hearing lips and seeing voices. | H McGurk, J MacDonald | Nature | 1976 | 1012311 | Yes |
| 3854 | 2338 | 1169.0 | 91.5 | 45.8 | Understanding face recognition. | V Bruce, A Young | Br J Psychol | 1986 | 3756376 | Yes |
| 3855 | 1169 | 1169.0 | 30.5 | 30.5 | Looking into the functional architecture of the brain with diffusion MRI. | Denis Le Bihan | Nat Rev Neurosci | 2003 | 12778119 | No |
| 3856 | 2338 | 1169.0 | 50.0 | 25.0 | GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor. | Sean Davis, Paul S Meltzer | Bioinformatics | 2007 | 17496320 | Yes |
| 3857 | 1169 | 1169.0 | 36.4 | 36.4 | Outer membrane permeability and antibiotic resistance. | Anne H Delcour | Biochim Biophys Acta | 2009 | 19100346 | No |
| 3858 | 2336 | 1168.0 | 62.5 | 31.2 | Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. | Donald E Owens, Nicholas A Peppas | Int J Pharm | 2006 | 16303268 | No |
| 3859 | 4672 | 1168.0 | 131.3 | 32.8 | voom: Precision weights unlock linear model analysis tools for RNA-seq read counts. | Charity W Law, Yunshun Chen, Wei Shi, Gordon K Smyth | Genome Biol | 2014 | 24485249 | Yes |
| 3860 | 2336 | 1168.0 | 103.6 | 51.8 | Biological Functions of Autophagy Genes: A Disease Perspective. | Beth Levine, Guido Kroemer | Cell | 2019 | 30633901 | No |
| 3861 | 4671 | 1167.8 | 124.3 | 31.1 | Wound repair and regeneration. | Geoffrey C Gurtner, Sabine Werner, Yann Barrandon, Michael T Longaker | Nature | 2008 | 18480812 | No |
| 3862 | 3502 | 1167.3 | 0.0 | 0.0 | Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. | A L Shapiro, E Vinuela, J V Maizel | Biochem Biophys Res Commun | 1967 | 4861258 | Yes |
| 3863 | 1167 | 1167.0 | 43.1 | 43.1 | Attention, similarity, and the identification-categorization relationship. | R M Nosofsky | J Exp Psychol Gen | 1986 | 2937873 | Yes |
| 3864 | 1167 | 1167.0 | 0.0 | 0.0 | Observations on the isolated phrenic nerve diaphragm preparation of the rat. | E Bulbring | Br J Pharmacol Chemother | 1946 | 20999334 | Yes |
| 3865 | 2333 | 1166.5 | 0.0 | 0.0 | Cortisone in ulcerative colitis; final report on a therapeutic trial. | S C Truelove, L J Witts | Br Med J | 1955 | 13260656 | Yes |
| 3866 | 2333 | 1166.5 | 64.1 | 32.0 | Cu-catalyzed azide-alkyne cycloaddition. | Morten Meldal, Christian Wenzel Tornoe | Chem Rev | 2008 | 18698735 | No |
| 3867 | 4665 | 1166.2 | 124.7 | 31.2 | REVIGO summarizes and visualizes long lists of gene ontology terms. | Fran Supek, Matko Bosnjak, Nives Skunca, Tomislav Smuc | PLoS One | 2011 | 21789182 | Yes |
| 3868 | 1166 | 1166.0 | 0.0 | 0.0 | Biogenic amines and the states of sleep. | M Jouvet | Science | 1969 | 4303225 | No |
| 3869 | 1166 | 1166.0 | 0.0 | 0.0 | The moulding of senescence by natural selection. | W D Hamilton | J Theor Biol | 1966 | 6015424 | Yes |
| 3870 | 1166 | 1166.0 | 35.9 | 35.9 | Leishmaniasis. | B L Herwaldt | Lancet | 1999 | 10513726 | No |
| 3871 | 1166 | 1166.0 | 46.1 | 46.1 | Subjective well-being. The science of happiness and a proposal for a national index. | E Diener | Am Psychol | 2000 | 11392863 | Yes |
| 3872 | 1166 | 1166.0 | 20.6 | 20.6 | 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. | Judith K Christman | Oncogene | 2002 | 12154409 | No |
| 3873 | 2331 | 1165.5 | 45.9 | 22.9 | NF-kappaB at the crossroads of life and death. | Michael Karin, Anning Lin | Nat Immunol | 2002 | 11875461 | No |
| 3874 | 2331 | 1165.5 | 92.6 | 46.3 | Mechanism and medical implications of mammalian autophagy. | Ivan Dikic, Zvulun Elazar | Nat Rev Mol Cell Biol | 2018 | 29618831 | No |
| 3875 | 1165 | 1165.0 | 27.6 | 27.6 | Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. | M M Tirion | Phys Rev Lett | 1996 | 10063201 | Yes |
| 3876 | 2330 | 1165.0 | 51.5 | 25.8 | Toll-like receptors in the induction of the innate immune response. | A Aderem, R J Ulevitch | Nature | 2000 | 10963608 | No |
| 3877 | 1165 | 1165.0 | 0.0 | 0.0 | The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. | J Vague | Am J Clin Nutr | 1956 | 13282851 | Yes |
| 3878 | 2330 | 1165.0 | 75.1 | 37.5 | Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. | Ivan Sondi, Branka Salopek-Sondi | J Colloid Interface Sci | 2004 | 15158396 | Yes |
| 3879 | 2330 | 1165.0 | 58.8 | 29.4 | The NF-kappaB family of transcription factors and its regulation. | Andrea Oeckinghaus, Sankar Ghosh | Cold Spring Harb Perspect Biol | 2009 | 20066092 | No |
| 3880 | 1165 | 1165.0 | 50.8 | 50.8 | The theory of planned behaviour: reactions and reflections. | Icek Ajzen | Psychol Health | 2011 | 21929476 | No |
| 3881 | 2329 | 1164.5 | 104.1 | 52.0 | Introduction to the human gut microbiota. | Elizabeth Thursby, Nathalie Juge | Biochem J | 2017 | 28512250 | No |
| 3882 | 1164 | 1164.0 | 47.8 | 47.8 | A review of psychological risk factors in back and neck pain. | S J Linton | Spine (Phila Pa 1976) | 2000 | 10788861 | No |
| 3883 | 1164 | 1164.0 | 0.0 | 0.0 | A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. | J B Brown | Biochem J | 1955 | 14389222 | Yes |
| 3884 | 2327 | 1163.5 | 54.9 | 27.4 | Cellular uptake of the tat protein from human immunodeficiency virus. | A D Frankel, C O Pabo | Cell | 1988 | 2849510 | Yes |
| 3885 | 2327 | 1163.5 | 63.4 | 31.7 | A general purpose model for the condensed phases of water: TIP4P/2005. | J L F Abascal, C Vega | J Chem Phys | 2005 | 16392929 | Yes |
| 3886 | 3489 | 1163.0 | 75.1 | 25.0 | A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. | M Serrano, G J Hannon, D Beach | Nature | 1993 | 8259215 | Yes |
| 3887 | 2326 | 1163.0 | 64.1 | 32.0 | Protein oxidation in aging, disease, and oxidative stress. | B S Berlett, E R Stadtman | J Biol Chem | 1997 | 9252331 | No |
| 3888 | 1163 | 1163.0 | 25.8 | 25.8 | Fluorescence spectroscopy of single biomolecules. | S Weiss | Science | 1999 | 10073925 | No |
| 3889 | 2326 | 1163.0 | 51.9 | 25.9 | An energy budget for signaling in the grey matter of the brain. | D Attwell, S B Laughlin | J Cereb Blood Flow Metab | 2001 | 11598490 | No |
| 3890 | 1163 | 1163.0 | 31.5 | 31.5 | Omega-3 fatty acids in inflammation and autoimmune diseases. | Artemis P Simopoulos | J Am Coll Nutr | 2002 | 12480795 | No |
| 3891 | 2324 | 1162.0 | 52.8 | 26.4 | Growth of a rat neuroblastoma cell line in serum-free supplemented medium. | J E Bottenstein, G H Sato | Proc Natl Acad Sci U S A | 1979 | 284369 | Yes |
| 3892 | 1162 | 1162.0 | 22.5 | 22.5 | Regulation of phosphoinositide-specific phospholipase C. | S G Rhee | Annu Rev Biochem | 2001 | 11395409 | No |
| 3893 | 1162 | 1162.0 | 34.3 | 34.3 | Ion suppression in mass spectrometry. | Thomas M Annesley | Clin Chem | 2003 | 12816898 | No |
| 3894 | 2324 | 1162.0 | 71.4 | 35.7 | ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. | Graham Noctor, Christine H Foyer | Annu Rev Plant Physiol Plant Mol Biol | 1998 | 15012235 | Yes |
| 3895 | 1162 | 1162.0 | 34.8 | 34.8 | Innate immunity of fish (overview). | Bergljot Magnadottir | Fish Shellfish Immunol | 2006 | 15950491 | No |
| 3896 | 1161 | 1161.0 | 0.0 | 0.0 | Selective coronary arteriography. I. A percutaneous transfemoral technic. | M P Judkins | Radiology | 1967 | 6048074 | Yes |
| 3897 | 1161 | 1161.0 | 32.0 | 32.0 | Glutathione and its role in cellular functions. | H Sies | Free Radic Biol Med | 1999 | 10569624 | No |
| 3898 | 1161 | 1161.0 | 22.0 | 22.0 | Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. | R A Frye | Biochem Biophys Res Commun | 2000 | 10873683 | Yes |
| 3899 | 8126 | 1160.9 | 144.5 | 20.6 | The human genome browser at UCSC. | W James Kent, Charles W Sugnet, Terrence S Furey, Krishna M Roskin, Tom H Pringle, Alan M Zahler, David Haussler | Genome Res | 2002 | 12045153 | Yes |
| 3900 | 3482 | 1160.7 | 96.4 | 32.1 | Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. | M K Parmar, V Torri, L Stewart | Stat Med | 1998 | 9921604 | Yes |
| 3901 | 2320 | 1160.0 | 74.2 | 37.1 | Role of oxidized low density lipoprotein in atherogenesis. | J L Witztum, D Steinberg | J Clin Invest | 1991 | 1752940 | No |
| 3902 | 1160 | 1160.0 | 28.3 | 28.3 | BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. | O Gascuel | Mol Biol Evol | 1997 | 9254330 | Yes |
| 3903 | 1160 | 1160.0 | 33.8 | 33.8 | Invited review: Aging and sarcopenia. | Timothy J Doherty | J Appl Physiol (1985) | 2003 | 12970377 | No |
| 3904 | 1160 | 1160.0 | 29.0 | 29.0 | Nitric oxide, oxidants, and protein tyrosine nitration. | Rafael Radi | Proc Natl Acad Sci U S A | 2004 | 15020765 | Yes |
| 3905 | 1160 | 1160.0 | 26.0 | 26.0 | Personal genomes: The case of the missing heritability. | Brendan Maher | Nature | 2008 | 18987709 | No |
| 3906 | 1160 | 1160.0 | 40.7 | 40.7 | The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium. | James A Imlay | Nat Rev Microbiol | 2013 | 23712352 | No |
| 3907 | 1160 | 1160.0 | 31.2 | 31.2 | Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. | Christof M Niemeyer | Angew Chem Int Ed Engl | 2001 | 29712109 | No |
| 3908 | 2319 | 1159.5 | 74.6 | 37.3 | Stool form scale as a useful guide to intestinal transit time. | S J Lewis, K W Heaton | Scand J Gastroenterol | 1997 | 9299672 | Yes |
| 3909 | 2319 | 1159.5 | 0.0 | 0.0 | Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. | R W Butcher, E W Sutherland | J Biol Chem | 1962 | 13875173 | Yes |
| 3910 | 1159 | 1159.0 | 60.1 | 60.1 | Mitochondrial Dynamics and Its Involvement in Disease. | David C Chan | Annu Rev Pathol | 2020 | 31585519 | No |
| 3911 | 5794 | 1158.8 | 325.2 | 65.0 | Posterior Summarization in Bayesian Phylogenetics Using Tracer 1.7. | Andrew Rambaut, Alexei J Drummond, Dong Xie, Guy Baele, Marc A Suchard | Syst Biol | 2018 | 29718447 | Yes |
| 3912 | 2317 | 1158.5 | 71.1 | 35.5 | Polymyositis and dermatomyositis (second of two parts). | A Bohan, J B Peter | N Engl J Med | 1975 | 1089199 | No |
| 3913 | 1158 | 1158.0 | 32.7 | 32.7 | Diseases of the mitochondrial DNA. | D C Wallace | Annu Rev Biochem | 1992 | 1497308 | No |
| 3914 | 2316 | 1158.0 | 44.2 | 22.1 | Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. | R Daniel Gietz, Robin A Woods | Methods Enzymol | 2002 | 12073338 | Yes |
| 3915 | 1158 | 1158.0 | 28.6 | 28.6 | NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. | Weihai Ying | Antioxid Redox Signal | 2008 | 18020963 | No |
| 3916 | 2315 | 1157.5 | 56.0 | 28.0 | Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. | M J Casadaban, S N Cohen | J Mol Biol | 1980 | 6997493 | Yes |
| 3917 | 2315 | 1157.5 | 71.3 | 35.6 | Nitric oxide synthases in mammals. | R G Knowles, S Moncada | Biochem J | 1994 | 7510950 | No |
| 3918 | 1157 | 1157.0 | 33.8 | 33.8 | Cholesterol and the cell membrane. | P L Yeagle | Biochim Biophys Acta | 1985 | 3904832 | No |
| 3919 | 1157 | 1157.0 | 17.3 | 17.3 | Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. | J J Hopfield | Proc Natl Acad Sci U S A | 1974 | 4530290 | Yes |
| 3920 | 1157 | 1157.0 | 0.0 | 0.0 | Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. | S Irwin | Psychopharmacologia | 1968 | 5679627 | Yes |
| 3921 | 1157 | 1157.0 | 46.0 | 46.0 | An advanced test of theory of mind: understanding of story characters' thoughts and feelings by able autistic, mentally handicapped, and normal children and adults. | F G Happe | J Autism Dev Disord | 1994 | 8040158 | Yes |
| 3922 | 1157 | 1157.0 | 25.1 | 25.1 | Alpha-synuclein and neurodegenerative diseases. | M Goedert | Nat Rev Neurosci | 2001 | 11433374 | No |
| 3923 | 5784 | 1156.8 | 206.7 | 41.3 | A new clinical scale for the staging of dementia. | C P Hughes, L Berg, W L Danziger, L A Coben, R L Martin | Br J Psychiatry | 1982 | 7104545 | Yes |
| 3924 | 2313 | 1156.5 | 60.4 | 30.2 | Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. | L Pellerin, P J Magistretti | Proc Natl Acad Sci U S A | 1994 | 7938003 | Yes |
| 3925 | 3469 | 1156.3 | 83.4 | 27.8 | High resolution two-dimensional electrophoresis of basic as well as acidic proteins. | P Z O'Farrell, H M Goodman, P H O'Farrell | Cell | 1977 | 23215 | Yes |
| 3926 | 1156 | 1156.0 | 25.3 | 25.3 | Stem cells in the central nervous system. | R McKay | Science | 1997 | 9082987 | No |
| 3927 | 1156 | 1156.0 | 0.0 | 0.0 | Motivation reconsidered: the concept of competence. | R W White | Psychol Rev | 1959 | 13844397 | Yes |
| 3928 | 1156 | 1156.0 | 28.7 | 28.7 | Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. | Frank Wurthner | Chem Commun (Camb) | 2004 | 15263926 | Yes |
| 3929 | 1156 | 1156.0 | 32.0 | 32.0 | Impact of 16S rRNA gene sequence analysis for identification of bacteria on clinical microbiology and infectious diseases. | Jill E Clarridge | Clin Microbiol Rev | 2004 | 15489351 | No |
| 3930 | 1156 | 1156.0 | 52.0 | 52.0 | Socioeconomic inequalities and mental health problems in children and adolescents: a systematic review. | Franziska Reiss | Soc Sci Med | 2013 | 23746605 | Yes |
| 3931 | 4623 | 1155.8 | 148.8 | 37.2 | The cholinergic hypothesis of geriatric memory dysfunction. | R T Bartus, R L Dean, B Beer, A S Lippa | Science | 1982 | 7046051 | No |
| 3932 | 2311 | 1155.5 | 93.0 | 46.5 | Glutathione reductase. | I Carlberg, B Mannervik | Methods Enzymol | 1985 | 3003504 | Yes |
| 3933 | 10396 | 1155.1 | 336.5 | 37.4 | Robust enumeration of cell subsets from tissue expression profiles. | Aaron M Newman, Chih Long Liu, Michael R Green, Andrew J Gentles, Weiguo Feng, Yue Xu, Chuong D Hoang, Maximilian Diehn, Ash A Alizadeh | Nat Methods | 2015 | 25822800 | Yes |
| 3934 | 1155 | 1155.0 | 28.6 | 28.6 | DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. | J F Ward | Prog Nucleic Acid Res Mol Biol | 1988 | 3065826 | No |
| 3935 | 1155 | 1155.0 | 0.0 | 0.0 | RNA metabolism in the HeLa cell nucleus. | S Penman | J Mol Biol | 1966 | 5961144 | Yes |
| 3936 | 1155 | 1155.0 | 23.9 | 23.9 | Differentiation and proliferation of hematopoietic stem cells. | M Ogawa | Blood | 1993 | 8499622 | No |
| 3937 | 1155 | 1155.0 | 0.0 | 0.0 | A sensitive method for the assay of 5-hydroxytryptamine. | J R Vane | Br J Pharmacol Chemother | 1957 | 13460242 | Yes |
| 3938 | 1155 | 1155.0 | 24.4 | 24.4 | Phenotypic plasticity and the epigenetics of human disease. | Andrew P Feinberg | Nature | 2007 | 17522677 | No |
| 3939 | 1155 | 1155.0 | 29.8 | 29.8 | Telomere length measurement by a novel monochrome multiplex quantitative PCR method. | Richard M Cawthon | Nucleic Acids Res | 2009 | 19129229 | Yes |
| 3940 | 4619 | 1154.8 | 0.0 | 0.0 | The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. | P J Randle, P B Garland, C N Hales, E A Newsholme | Lancet | 1963 | 13990765 | Yes |
| 3941 | 1154 | 1154.0 | 0.0 | 0.0 | The tragedy of the commons. The population problem has no technical solution; it requires a fundamental extension in morality. | G Hardin | Science | 1968 | 5699198 | Yes |
| 3942 | 1154 | 1154.0 | 36.0 | 36.0 | Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. | W Sieghart | Pharmacol Rev | 1995 | 7568326 | No |
| 3943 | 1154 | 1154.0 | 30.3 | 30.3 | Hybridization as an invasion of the genome. | James Mallet | Trends Ecol Evol | 2005 | 16701374 | Yes |
| 3944 | 1154 | 1154.0 | 27.4 | 27.4 | Mucins in cancer: function, prognosis and therapy. | Donald W Kufe | Nat Rev Cancer | 2009 | 19935676 | No |
| 3945 | 3461 | 1153.7 | 79.7 | 26.6 | Mitochondria, oxidants, and aging. | Robert S Balaban, Shino Nemoto, Toren Finkel | Cell | 2005 | 15734681 | No |
| 3946 | 2307 | 1153.5 | 47.8 | 23.9 | A survey of telomerase activity in human cancer. | J W Shay, S Bacchetti | Eur J Cancer | 1997 | 9282118 | No |
| 3947 | 2307 | 1153.5 | 80.2 | 40.1 | Fundamentals of cancer metabolism. | Ralph J DeBerardinis, Navdeep S Chandel | Sci Adv | 2016 | 27386546 | No |
| 3948 | 3460 | 1153.3 | 103.7 | 34.6 | Foreign body reaction to biomaterials. | James M Anderson, Analiz Rodriguez, David T Chang | Semin Immunol | 2008 | 18162407 | No |
| 3949 | 1153 | 1153.0 | 94.9 | 94.9 | Fibula free flap: a new method of mandible reconstruction. | D A Hidalgo | Plast Reconstr Surg | 1989 | 2734406 | Yes |
| 3950 | 2306 | 1153.0 | 63.0 | 31.5 | Oxidative stress, caloric restriction, and aging. | R S Sohal, R Weindruch | Science | 1996 | 8658196 | No |
| 3951 | 1153 | 1153.0 | 38.1 | 38.1 | Reducing children's television viewing to prevent obesity: a randomized controlled trial. | T N Robinson | JAMA | 1999 | 10546696 | Yes |
| 3952 | 1153 | 1153.0 | 21.5 | 21.5 | The development of neural stem cells. | S Temple | Nature | 2001 | 11689956 | No |
| 3953 | 2305 | 1152.5 | 45.7 | 22.9 | Homeobox genes and axial patterning. | W McGinnis, R Krumlauf | Cell | 1992 | 1346368 | No |
| 3954 | 2305 | 1152.5 | 92.3 | 46.1 | Visual search and stimulus similarity. | J Duncan, G W Humphreys | Psychol Rev | 1989 | 2756067 | Yes |
| 3955 | 2305 | 1152.5 | 59.7 | 29.9 | The oxytocin receptor system: structure, function, and regulation. | G Gimpl, F Fahrenholz | Physiol Rev | 2001 | 11274341 | No |
| 3956 | 1152 | 1152.0 | 26.6 | 26.6 | Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. | D L Coleman | Diabetologia | 1978 | 350680 | No |
| 3957 | 2304 | 1152.0 | 64.0 | 32.0 | Plasminogen: purification from human plasma by affinity chromatography. | D G Deutsch, E T Mertz | Science | 1970 | 5475635 | Yes |
| 3958 | 1152 | 1152.0 | 31.3 | 31.3 | The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. | David S Ludwig | JAMA | 2002 | 11988062 | No |
| 3959 | 1152 | 1152.0 | 35.1 | 35.1 | α-Synuclein in Parkinson's disease. | Leonidas Stefanis | Cold Spring Harb Perspect Med | 2012 | 22355802 | No |
| 3960 | 2303 | 1151.5 | 95.8 | 47.9 | The structure of psychological well-being revisited. | C D Ryff, C L Keyes | J Pers Soc Psychol | 1995 | 7473027 | Yes |
| 3961 | 1151 | 1151.0 | 60.8 | 60.8 | The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. | G A Ilizarov | Clin Orthop Relat Res | 1989 | 2912628 | Yes |
| 3962 | 1151 | 1151.0 | 27.6 | 27.6 | The neurobiology of consolidations, or, how stable is the engram? | Yadin Dudai | Annu Rev Psychol | 2004 | 14744210 | No |
| 3963 | 1151 | 1151.0 | 0.0 | 0.0 | The stereotaxic method and radiosurgery of the brain. | L Leksell | Acta Chir Scand | 1951 | 14914373 | Yes |
| 3964 | 1151 | 1151.0 | 35.4 | 35.4 | Cytochrome p450 and chemical toxicology. | F Peter Guengerich | Chem Res Toxicol | 2008 | 18052394 | No |
| 3965 | 2301 | 1150.5 | 112.4 | 56.2 | Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. | Justin M Long, David M Holtzman | Cell | 2019 | 31564456 | No |
| 3966 | 1150 | 1150.0 | 32.4 | 32.4 | DNA topoisomerases. | M Gellert | Annu Rev Biochem | 1981 | 6267993 | No |
| 3967 | 2300 | 1150.0 | 104.6 | 52.3 | Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. | J B Mulliken, J Glowacki | Plast Reconstr Surg | 1982 | 7063565 | Yes |
| 3968 | 1150 | 1150.0 | 27.3 | 27.3 | Molecular drive: a cohesive mode of species evolution. | G Dover | Nature | 1982 | 7110332 | Yes |
| 3969 | 3450 | 1150.0 | 70.0 | 23.3 | Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. | Paola Scaffidi, Tom Misteli, Marco E Bianchi | Nature | 2002 | 12110890 | Yes |
| 3970 | 1150 | 1150.0 | 29.3 | 29.3 | The emotional brain, fear, and the amygdala. | Joseph LeDoux | Cell Mol Neurobiol | 2003 | 14514027 | No |
| 3971 | 1150 | 1150.0 | 28.1 | 28.1 | Targeting cancer metabolism: a therapeutic window opens. | Matthew G Vander Heiden | Nat Rev Drug Discov | 2011 | 21878982 | No |
| 3972 | 1150 | 1150.0 | 45.3 | 45.3 | A comprehensive review on metabolic syndrome. | Jaspinder Kaur | Cardiol Res Pract | 2014 | 24711954 | No |
| 3973 | 3449 | 1149.7 | 86.6 | 28.9 | Functional diversity of helper T lymphocytes. | A K Abbas, K M Murphy, A Sher | Nature | 1996 | 8893001 | No |
| 3974 | 2298 | 1149.0 | 47.8 | 23.9 | Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. | G A Gonzalez, M R Montminy | Cell | 1989 | 2573431 | Yes |
| 3975 | 1149 | 1149.0 | 0.0 | 0.0 | Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. | C M Venkatachalam | Biopolymers | 1968 | 5685102 | Yes |
| 3976 | 1149 | 1149.0 | 34.8 | 34.8 | Limbic-cortical dysregulation: a proposed model of depression. | H S Mayberg | J Neuropsychiatry Clin Neurosci | 1997 | 9276848 | No |
| 3977 | 4595 | 1148.8 | 91.5 | 22.9 | DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. | M Okano, D W Bell, D A Haber, E Li | Cell | 1999 | 10555141 | Yes |
| 3978 | 11488 | 1148.8 | 438.8 | 43.9 | The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. | Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gotzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David Moher | PLoS Med | 2009 | 19621070 | No |
| 3979 | 2297 | 1148.5 | 56.6 | 28.3 | CpG islands and the regulation of transcription. | Aimee M Deaton, Adrian Bird | Genes Dev | 2011 | 21576262 | No |
| 3980 | 2297 | 1148.5 | 63.3 | 31.6 | DNA methylation: roles in mammalian development. | Zachary D Smith, Alexander Meissner | Nat Rev Genet | 2013 | 23400093 | No |
| 3981 | 1148 | 1148.0 | 21.3 | 21.3 | Structure of chromatin. | R D Kornberg | Annu Rev Biochem | 1977 | 332067 | No |
| 3982 | 1148 | 1148.0 | 44.3 | 44.3 | Perceptual selectivity for color and form. | J Theeuwes | Percept Psychophys | 1992 | 1620571 | No |
| 3983 | 3444 | 1148.0 | 95.8 | 31.9 | Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. | R Schreck, P Rieber, P A Baeuerle | EMBO J | 1991 | 2065663 | Yes |
| 3984 | 1148 | 1148.0 | 26.2 | 26.2 | Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. | D B Clewell | J Bacteriol | 1972 | 4336693 | Yes |
| 3985 | 1148 | 1148.0 | 0.0 | 0.0 | Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. | D L Morris | Science | 1948 | 17814729 | Yes |
| 3986 | 2296 | 1148.0 | 76.0 | 38.0 | The economy of brain network organization. | Ed Bullmore, Olaf Sporns | Nat Rev Neurosci | 2012 | 22498897 | No |
| 3987 | 11478 | 1147.8 | 470.6 | 47.1 | QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. | Penny F Whiting, Anne W S Rutjes, Marie E Westwood, Susan Mallett, Jonathan J Deeks, Johannes B Reitsma, Mariska M G Leeflang, Jonathan A C Sterne, Patrick M M Bossuyt, | Ann Intern Med | 2011 | 22007046 | Yes |
| 3988 | 2295 | 1147.5 | 0.0 | 0.0 | Modified reagents for determination of urea and ammonia. | A L Chaney, E P Marbach | Clin Chem | 1962 | 13878063 | Yes |
| 3989 | 6880 | 1146.7 | 164.0 | 27.3 | Alpha-synuclein in Lewy bodies. | M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M Goedert | Nature | 1997 | 9278044 | Yes |
| 3990 | 2293 | 1146.5 | 55.9 | 27.9 | Clonal evolution in cancer. | Mel Greaves, Carlo C Maley | Nature | 2012 | 22258609 | No |
| 3991 | 2293 | 1146.5 | 73.4 | 36.7 | PARP inhibitors: Synthetic lethality in the clinic. | Christopher J Lord, Alan Ashworth | Science | 2017 | 28302823 | No |
| 3992 | 3439 | 1146.3 | 137.1 | 45.7 | Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA approved pharmaceuticals. | Edon Vitaku, David T Smith, Jon T Njardarson | J Med Chem | 2014 | 25255204 | No |
| 3993 | 1146 | 1146.0 | 35.2 | 35.2 | Unstable angina. A classification. | E Braunwald | Circulation | 1989 | 2752565 | Yes |
| 3994 | 1146 | 1146.0 | 39.7 | 39.7 | The Delphi technique: myths and realities. | Catherine Powell | J Adv Nurs | 2003 | 12581103 | No |
| 3995 | 2291 | 1145.5 | 77.8 | 38.9 | Wine, alcohol, platelets, and the French paradox for coronary heart disease. | S Renaud, M De Lorgeril | Lancet | 1992 | 1351198 | Yes |
| 3996 | 2291 | 1145.5 | 63.1 | 31.6 | Adjusting for multiple testing--when and how? | R Bender, S Lange | J Clin Epidemiol | 2001 | 11297884 | No |
| 3997 | 2291 | 1145.5 | 0.0 | 0.0 | Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. | H H Ussing, K Zerahn | Acta Physiol Scand | 1951 | 14868510 | Yes |
| 3998 | 1145 | 1145.0 | 44.3 | 44.3 | Radioimmunological determination of human C-peptide in serum. | L G Heding | Diabetologia | 1975 | 1239396 | Yes |
| 3999 | 1145 | 1145.0 | 25.6 | 25.6 | Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. | T Ikemura | J Mol Biol | 1981 | 6175758 | Yes |
| 4000 | 2290 | 1145.0 | 66.4 | 33.2 | The cerebellar cognitive affective syndrome. | J D Schmahmann, J C Sherman | Brain | 1998 | 9577385 | Yes |
| 4001 | 1145 | 1145.0 | 0.0 | 0.0 | Inherited Antithrombin Deficiency Causing Thrombophilia. | O Egeberg | Thromb Diath Haemorrh | 1965 | 14347873 | Yes |
| 4002 | 1145 | 1145.0 | 24.9 | 24.9 | Large-scale recording of neuronal ensembles. | Gyorgy Buzsaki | Nat Neurosci | 2004 | 15114356 | No |
| 4003 | 1145 | 1145.0 | 33.5 | 33.5 | Micellar nanocarriers: pharmaceutical perspectives. | V P Torchilin | Pharm Res | 2007 | 17109211 | No |
| 4004 | 1145 | 1145.0 | 40.6 | 40.6 | Chemistry and biochemistry of dietary polyphenols. | Rong Tsao | Nutrients | 2010 | 22254006 | No |
| 4005 | 1145 | 1145.0 | 38.7 | 38.7 | Targeting metastasis. | Patricia S Steeg | Nat Rev Cancer | 2016 | 27009393 | No |
| 4006 | 1145 | 1145.0 | 59.0 | 59.0 | Why is depression more common among women than among men? | Christine Kuehner | Lancet Psychiatry | 2017 | 27856392 | No |
| 4007 | 2289 | 1144.5 | 63.8 | 31.9 | Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. | D Rice, S Barone | Environ Health Perspect | 2000 | 10852851 | No |
| 4008 | 2289 | 1144.5 | 58.7 | 29.4 | Inflammatory bowel disease. | Clara Abraham, Judy H Cho | N Engl J Med | 2009 | 19923578 | No |
| 4009 | 4577 | 1144.2 | 117.6 | 29.4 | Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. | H Nielsen, J Engelbrecht, S Brunak, G Von Heijne | Protein Eng | 1997 | 9051728 | Yes |
| 4010 | 1144 | 1144.0 | 29.4 | 29.4 | Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. | I J Fidler | Cancer Res | 1990 | 1698118 | Yes |
| 4011 | 1144 | 1144.0 | 28.5 | 28.5 | Allelic discrimination using fluorogenic probes and the 5' nuclease assay. | K J Livak | Genet Anal | 1999 | 10084106 | Yes |
| 4012 | 2288 | 1144.0 | 96.0 | 48.0 | Global estimates of visual impairment: 2010. | Donatella Pascolini, Silvio Paolo Mariotti | Br J Ophthalmol | 2012 | 22133988 | Yes |
| 4013 | 4575 | 1143.8 | 165.6 | 41.4 | A basic introduction to fixed-effect and random-effects models for meta-analysis. | Michael Borenstein, Larry V Hedges, Julian P T Higgins, Hannah R Rothstein | Res Synth Methods | 2010 | 26061376 | Yes |
| 4014 | 2287 | 1143.5 | 74.3 | 37.1 | A rating scale for extrapyramidal side effects. | G M Simpson, J W Angus | Acta Psychiatr Scand Suppl | 1970 | 4917967 | Yes |
| 4015 | 2286 | 1143.0 | 65.2 | 32.6 | Flexible regression models with cubic splines. | S Durrleman, R Simon | Stat Med | 1989 | 2657958 | Yes |
| 4016 | 1143 | 1143.0 | 31.1 | 31.1 | An improved fluorometric assay for DNA. | R T Hinegardner | Anal Biochem | 1971 | 5544593 | Yes |
| 4017 | 1143 | 1143.0 | 40.7 | 40.7 | Perceptual load as a necessary condition for selective attention. | N Lavie | J Exp Psychol Hum Percept Perform | 1995 | 7790827 | Yes |
| 4018 | 1143 | 1143.0 | 0.0 | 0.0 | On the prediction of occurrence of particular verbal intrusions in immediate recall. | J Deese | J Exp Psychol | 1959 | 13664879 | Yes |
| 4019 | 1143 | 1143.0 | 22.9 | 22.9 | Inferences, questions and possibilities in Toll-like receptor signalling. | Bruce Beutler | Nature | 2004 | 15241424 | No |
| 4020 | 1143 | 1143.0 | 22.7 | 22.7 | The evolutionary significance of cis-regulatory mutations. | Gregory A Wray | Nat Rev Genet | 2007 | 17304246 | No |
| 4021 | 1143 | 1143.0 | 0.0 | 0.0 | A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. | R D Hotchkiss | Arch Biochem | 1948 | 18921848 | Yes |
| 4022 | 3428 | 1142.7 | 87.7 | 29.2 | Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. | G M Wahl, M Stern, G R Stark | Proc Natl Acad Sci U S A | 1979 | 291033 | Yes |
| 4023 | 2285 | 1142.5 | 64.4 | 32.2 | The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. | Alicia A Walf, Cheryl A Frye | Nat Protoc | 2007 | 17406592 | Yes |
| 4024 | 2284 | 1142.0 | 74.7 | 37.4 | Severe psoriasis--oral therapy with a new retinoid. | T Fredriksson, U Pettersson | Dermatologica | 1978 | 357213 | Yes |
| 4025 | 1142 | 1142.0 | 15.6 | 15.6 | Cell lines derived from late embryonic stages of Drosophila melanogaster. | I Schneider | J Embryol Exp Morphol | 1972 | 4625067 | Yes |
| 4026 | 2284 | 1142.0 | 52.1 | 26.1 | InterProScan--an integration platform for the signature-recognition methods in InterPro. | E M Zdobnov, R Apweiler | Bioinformatics | 2001 | 11590104 | Yes |
| 4027 | 1142 | 1142.0 | 24.9 | 24.9 | The muscular dystrophies. | Alan E H Emery | Lancet | 2002 | 11879882 | No |
| 4028 | 4565 | 1141.2 | 108.7 | 27.2 | SCOP: a structural classification of proteins database for the investigation of sequences and structures. | A G Murzin, S E Brenner, T Hubbard, C Chothia | J Mol Biol | 1995 | 7723011 | Yes |
| 4029 | 1141 | 1141.0 | 20.0 | 20.0 | Shrinkage necrosis: a distinct mode of cellular death. | J F Kerr | J Pathol | 1971 | 4108566 | Yes |
| 4030 | 1141 | 1141.0 | 25.1 | 25.1 | Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. | M Kozak | Nucleic Acids Res | 1981 | 7301588 | Yes |
| 4031 | 1141 | 1141.0 | 0.0 | 0.0 | The effect of emotion on cue utilization and the organization of behavior. | J A Easterbrook | Psychol Rev | 1959 | 13658305 | Yes |
| 4032 | 1141 | 1141.0 | 0.0 | 0.0 | Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. | R J Pennington | Biochem J | 1961 | 13734134 | Yes |
| 4033 | 1141 | 1141.0 | 0.0 | 0.0 | Diffusion-in-gel methods for immunological analysis. II. | O Ouchterlony | Prog Allergy | 1962 | 14482809 | Yes |
| 4034 | 2282 | 1141.0 | 71.3 | 35.6 | The human microbiome: at the interface of health and disease. | Ilseung Cho, Martin J Blaser | Nat Rev Genet | 2012 | 22411464 | No |
| 4035 | 1141 | 1141.0 | 36.2 | 36.2 | Molecular pathogenesis and mechanisms of thyroid cancer. | Mingzhao Xing | Nat Rev Cancer | 2013 | 23429735 | No |
| 4036 | 1141 | 1141.0 | 39.1 | 39.1 | Measures of Diagnostic Accuracy: Basic Definitions. | Ana-Maria Simundic | EJIFCC | 2009 | 27683318 | Yes |
| 4037 | 2281 | 1140.5 | 62.2 | 31.1 | Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. | R A Ignotz, J Massague | J Biol Chem | 1986 | 3456347 | Yes |
| 4038 | 1140 | 1140.0 | 34.4 | 34.4 | Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. | M J Gasson | J Bacteriol | 1983 | 6403500 | Yes |
| 4039 | 1140 | 1140.0 | 29.9 | 29.9 | Anti-inflammatory actions of glucocorticoids: molecular mechanisms. | P J Barnes | Clin Sci (Lond) | 1998 | 9854452 | No |
| 4040 | 1140 | 1140.0 | 39.4 | 39.4 | Spontaneous dissection of the carotid and vertebral arteries. | W I Schievink | N Engl J Med | 2001 | 11259724 | No |
| 4041 | 1140 | 1140.0 | 0.0 | 0.0 | Neural basis of the spontaneous optokinetic response produced by visual inversion. | R W Sperry | J Comp Physiol Psychol | 1950 | 14794830 | Yes |
| 4042 | 1140 | 1140.0 | 52.9 | 52.9 | Dietary fiber and prebiotics and the gastrointestinal microbiota. | Hannah D Holscher | Gut Microbes | 2017 | 28165863 | No |
| 4043 | 1139 | 1139.0 | 26.6 | 26.6 | New ideas about atrial fibrillation 50 years on. | Stanley Nattel | Nature | 2002 | 11805846 | No |
| 4044 | 1139 | 1139.0 | 22.1 | 22.1 | Focal adhesion kinase: the first ten years. | J Thomas Parsons | J Cell Sci | 2003 | 12640026 | No |
| 4045 | 1139 | 1139.0 | 23.4 | 23.4 | Automated NMR structure calculation with CYANA. | Peter Guntert | Methods Mol Biol | 2004 | 15318003 | Yes |
| 4046 | 2277 | 1138.5 | 42.6 | 21.3 | T antigen is bound to a host protein in SV40-transformed cells. | D P Lane, L V Crawford | Nature | 1979 | 218111 | Yes |
| 4047 | 2277 | 1138.5 | 98.4 | 49.2 | Development of primer sets designed for use with the PCR to amplify conserved genes from filamentous ascomycetes. | N L Glass, G C Donaldson | Appl Environ Microbiol | 1995 | 7747954 | Yes |
| 4048 | 2277 | 1138.5 | 67.0 | 33.5 | How should meta-regression analyses be undertaken and interpreted? | Simon G Thompson, Julian P T Higgins | Stat Med | 2002 | 12111920 | Yes |
| 4049 | 2277 | 1138.5 | 72.2 | 36.1 | Exploring the brain network: a review on resting-state fMRI functional connectivity. | Martijn P Van Den Heuvel, Hilleke E Hulshoff Pol | Eur Neuropsychopharmacol | 2010 | 20471808 | No |
| 4050 | 1138 | 1138.0 | 22.5 | 22.5 | Mechanisms and consequences of activation of protein kinase B/Akt. | J Downward | Curr Opin Cell Biol | 1998 | 9561851 | No |
| 4051 | 2276 | 1138.0 | 68.8 | 34.4 | Systematic optimization of long-range corrected hybrid density functionals. | Jeng-Da Chai, Martin Head-Gordon | J Chem Phys | 2008 | 18315032 | Yes |
| 4052 | 2275 | 1137.5 | 53.4 | 26.7 | How to interpret LC3 immunoblotting. | Noboru Mizushima, Tamotsu Yoshimori | Autophagy | 2007 | 17611390 | No |
| 4053 | 1137 | 1137.0 | 36.2 | 36.2 | Protein damage and degradation by oxygen radicals. I. general aspects. | K J Davies | J Biol Chem | 1987 | 3036875 | Yes |
| 4054 | 1137 | 1137.0 | 37.2 | 37.2 | Food reward: brain substrates of wanting and liking. | K C Berridge | Neurosci Biobehav Rev | 1996 | 8622814 | No |
| 4055 | 3409 | 1136.3 | 142.2 | 47.4 | A new method for detecting anaerobic threshold by gas exchange. | W L Beaver, K Wasserman, B J Whipp | J Appl Physiol (1985) | 1986 | 3087938 | Yes |
| 4056 | 3409 | 1136.3 | 115.8 | 38.6 | A new rating scale for Alzheimer's disease. | W G Rosen, R C Mohs, K L Davis | Am J Psychiatry | 1984 | 6496779 | Yes |
| 4057 | 1136 | 1136.0 | 36.5 | 36.5 | Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. | J E Oesterling | J Urol | 1991 | 1707989 | No |
| 4058 | 2272 | 1136.0 | 46.9 | 23.4 | A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. | N C Andrews, D V Faller | Nucleic Acids Res | 1991 | 2041787 | Yes |
| 4059 | 1136 | 1136.0 | 37.1 | 37.1 | Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. | W A Catterall | Annu Rev Pharmacol Toxicol | 1980 | 6247957 | No |
| 4060 | 1136 | 1136.0 | 37.2 | 37.2 | The central autonomic network: functional organization, dysfunction, and perspective. | E E Benarroch | Mayo Clin Proc | 1993 | 8412366 | No |
| 4061 | 1136 | 1136.0 | 31.3 | 31.3 | Biological effects of resveratrol. | L Fremont | Life Sci | 2000 | 10680575 | No |
| 4062 | 1136 | 1136.0 | 35.0 | 35.0 | Inhibition of return. | R M Klein | Trends Cogn Sci | 2000 | 10740278 | Yes |
| 4063 | 1136 | 1136.0 | 23.5 | 23.5 | Unfolding the role of protein misfolding in neurodegenerative diseases. | Claudio Soto | Nat Rev Neurosci | 2003 | 12511861 | No |
| 4064 | 1136 | 1136.0 | 31.6 | 31.6 | Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. | Paul H Yancey | J Exp Biol | 2005 | 16043587 | No |
| 4065 | 2272 | 1136.0 | 93.6 | 46.8 | Implementation matters: a review of research on the influence of implementation on program outcomes and the factors affecting implementation. | Joseph A Durlak, Emily P DuPre | Am J Community Psychol | 2008 | 18322790 | No |
| 4066 | 1136 | 1136.0 | 30.3 | 30.3 | Forests and climate change: forcings, feedbacks, and the climate benefits of forests. | Gordon B Bonan | Science | 2008 | 18556546 | No |
| 4067 | 1136 | 1136.0 | 0.0 | 0.0 | pA, a new scale for the measurement of drug antagonism. | H O Schild | Br J Pharmacol Chemother | 1947 | 20258355 | Yes |
| 4068 | 1136 | 1136.0 | 37.6 | 37.6 | Designing cell-compatible hydrogels for biomedical applications. | Dror Seliktar | Science | 2012 | 22654050 | No |
| 4069 | 3407 | 1135.7 | 130.0 | 43.3 | Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. | P S Walsh, D A Metzger, R Higuchi | Biotechniques | 1991 | 1867860 | Yes |
| 4070 | 1135 | 1135.0 | 36.2 | 36.2 | Tests for emotionality in rats and mice: a review. | J Archer | Anim Behav | 1973 | 4578750 | No |
| 4071 | 1135 | 1135.0 | 25.3 | 25.3 | The molecular biology of coronaviruses. | Paul S Masters | Adv Virus Res | 2006 | 16877062 | No |
| 4072 | 1135 | 1135.0 | 25.2 | 25.2 | Evolution of the neocortex: a perspective from developmental biology. | Pasko Rakic | Nat Rev Neurosci | 2009 | 19763105 | No |
| 4073 | 4539 | 1134.8 | 135.7 | 33.9 | PACKMOL: a package for building initial configurations for molecular dynamics simulations. | L Martinez, R Andrade, E G Birgin, J M Martinez | J Comput Chem | 2009 | 19229944 | Yes |
| 4074 | 2269 | 1134.5 | 78.5 | 39.2 | Plant polyphenols as dietary antioxidants in human health and disease. | Kanti Bhooshan Pandey, Syed Ibrahim Rizvi | Oxid Med Cell Longev | 2009 | 20716914 | No |
| 4075 | 1134 | 1134.0 | 55.0 | 55.0 | Cytoprotection by prostaglandins. | A Robert | Gastroenterology | 1979 | 38173 | Yes |
| 4076 | 1134 | 1134.0 | 43.8 | 43.8 | Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. | J N Wasserheit | Sex Transm Dis | 1992 | 1595015 | No |
| 4077 | 1134 | 1134.0 | 36.2 | 36.2 | Image matching as a diffusion process: an analogy with Maxwell's demons. | J P Thirion | Med Image Anal | 1998 | 9873902 | Yes |
| 4078 | 2267 | 1133.5 | 57.9 | 28.9 | ARAGORN, a program to detect tRNA genes and tmRNA genes in nucleotide sequences. | Dean Laslett, Bjorn Canback | Nucleic Acids Res | 2004 | 14704338 | Yes |
| 4079 | 2267 | 1133.5 | 53.8 | 26.9 | Mechanisms of endocytosis. | Gary J Doherty, Harvey T McMahon | Annu Rev Biochem | 2009 | 19317650 | No |
| 4080 | 3400 | 1133.3 | 90.9 | 30.3 | Cytochemical identification of monocytes and granulocytes. | L T Yam, C Y Li, W H Crosby | Am J Clin Pathol | 1971 | 5549896 | Yes |
| 4081 | 1133 | 1133.0 | 0.0 | 0.0 | Why people use health services. | I M Rosenstock | Milbank Mem Fund Q | 1966 | 5967464 | Yes |
| 4082 | 1133 | 1133.0 | 21.5 | 21.5 | Chronic myeloid leukemia. | C L Sawyers | N Engl J Med | 1999 | 10219069 | No |
| 4083 | 1133 | 1133.0 | 31.2 | 31.2 | The developmental origins of adult disease. | D J P Barker | J Am Coll Nutr | 2004 | 15640511 | No |
| 4084 | 2266 | 1133.0 | 90.2 | 45.1 | Microglia Function in the Central Nervous System During Health and Neurodegeneration. | Marco Colonna, Oleg Butovsky | Annu Rev Immunol | 2017 | 28226226 | No |
| 4085 | 2266 | 1133.0 | 87.5 | 43.8 | DNA methylation-based biomarkers and the epigenetic clock theory of ageing. | Steve Horvath, Kenneth Raj | Nat Rev Genet | 2018 | 29643443 | No |
| 4086 | 11330 | 1133.0 | 446.9 | 44.7 | Comprehensive Integration of Single-Cell Data. | Tim Stuart, Andrew Butler, Paul Hoffman, Christoph Hafemeister, Efthymia Papalexi, William M Mauck, Yuhan Hao, Marlon Stoeckius, Peter Smibert, Rahul Satija | Cell | 2019 | 31178118 | Yes |
| 4087 | 2265 | 1132.5 | 50.1 | 25.1 | Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. | P J Roberts, C J Der | Oncogene | 2007 | 17496923 | No |
| 4088 | 2265 | 1132.5 | 59.2 | 29.6 | Recent developments in the MAFFT multiple sequence alignment program. | Kazutaka Katoh, Hiroyuki Toh | Brief Bioinform | 2008 | 18372315 | Yes |
| 4089 | 3397 | 1132.3 | 76.4 | 25.5 | FIMO: scanning for occurrences of a given motif. | Charles E Grant, Timothy L Bailey, William Stafford Noble | Bioinformatics | 2011 | 21330290 | Yes |
| 4090 | 1132 | 1132.0 | 24.3 | 24.3 | Mutator phenotype may be required for multistage carcinogenesis. | L A Loeb | Cancer Res | 1991 | 2039987 | No |
| 4091 | 1132 | 1132.0 | 21.9 | 21.9 | Contingent genetic regulatory events in T lymphocyte activation. | G R Crabtree | Science | 1989 | 2783497 | Yes |
| 4092 | 1132 | 1132.0 | 32.0 | 32.0 | Transport of molecules in the tumor interstitium: a review. | R K Jain | Cancer Res | 1987 | 3555767 | No |
| 4093 | 2264 | 1132.0 | 47.1 | 23.6 | RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. | M B Shapiro, P Senapathy | Nucleic Acids Res | 1987 | 3658675 | Yes |
| 4094 | 1132 | 1132.0 | 24.5 | 24.5 | Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. | Z Yang | Mol Biol Evol | 1998 | 9580986 | Yes |
| 4095 | 1132 | 1132.0 | 25.3 | 25.3 | The self-tuning neuron: synaptic scaling of excitatory synapses. | Gina G Turrigiano | Cell | 2008 | 18984155 | No |
| 4096 | 3396 | 1132.0 | 164.4 | 54.8 | miRBase: from microRNA sequences to function. | Ana Kozomara, Maria Birgaoanu, Sam Griffiths-Jones | Nucleic Acids Res | 2019 | 30423142 | Yes |
| 4097 | 2263 | 1131.5 | 70.2 | 35.1 | Fiber types in mammalian skeletal muscles. | Stefano Schiaffino, Carlo Reggiani | Physiol Rev | 2011 | 22013216 | No |
| 4098 | 1131 | 1131.0 | 51.6 | 51.6 | Movement, posture and equilibrium: interaction and coordination. | J Massion | Prog Neurobiol | 1992 | 1736324 | No |
| 4099 | 1131 | 1131.0 | 40.6 | 40.6 | Sex-hormone-binding globulin. | D C Anderson | Clin Endocrinol (Oxf) | 1974 | 4134992 | No |
| 4100 | 1131 | 1131.0 | 40.1 | 40.1 | On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. | D Collen | Thromb Haemost | 1980 | 6450468 | No |
| 4101 | 1131 | 1131.0 | 26.9 | 26.9 | A cortical-hippocampal system for declarative memory. | H Eichenbaum | Nat Rev Neurosci | 2000 | 11252767 | No |
| 4102 | 1131 | 1131.0 | 38.4 | 38.4 | Vitamin D status: measurement, interpretation, and clinical application. | Michael F Holick | Ann Epidemiol | 2009 | 18329892 | No |
| 4103 | 2261 | 1130.5 | 52.1 | 26.1 | p21 in cancer: intricate networks and multiple activities. | Tarek Abbas, Anindya Dutta | Nat Rev Cancer | 2009 | 19440234 | No |
| 4104 | 1130 | 1130.0 | 62.2 | 62.2 | The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. | J A Koufman | Laryngoscope | 1991 | 1895864 | No |
| 4105 | 1130 | 1130.0 | 20.5 | 20.5 | The evolutionary advantage of recombination. | J Felsenstein | Genetics | 1974 | 4448362 | Yes |
| 4106 | 1130 | 1130.0 | 27.8 | 27.8 | Cells in stress: transcriptional activation of heat shock genes. | R I Morimoto | Science | 1993 | 8451637 | No |
| 4107 | 1130 | 1130.0 | 40.3 | 40.3 | Why we need observational studies to evaluate the effectiveness of health care. | N Black | BMJ | 1996 | 8634569 | Yes |
| 4108 | 1130 | 1130.0 | 19.3 | 19.3 | Molecular mechanisms of axon guidance. | Barry J Dickson | Science | 2002 | 12471249 | No |
| 4109 | 1129 | 1129.0 | 51.8 | 51.8 | The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. | J Cassel | Am J Epidemiol | 1976 | 782233 | No |
| 4110 | 1129 | 1129.0 | 29.3 | 29.3 | Linkage strategies for genetically complex traits. I. Multilocus models. | N Risch | Am J Hum Genet | 1990 | 2301392 | Yes |
| 4111 | 1129 | 1129.0 | 31.3 | 31.3 | Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. | M M Weiser | J Biol Chem | 1973 | 4698230 | Yes |
| 4112 | 1129 | 1129.0 | 36.8 | 36.8 | Microbial heavy-metal resistance. | D H Nies | Appl Microbiol Biotechnol | 1999 | 10422221 | No |
| 4113 | 1129 | 1129.0 | 25.6 | 25.6 | Complement. Second of two parts. | M J Walport | N Engl J Med | 2001 | 11297706 | No |
| 4114 | 1129 | 1129.0 | 32.1 | 32.1 | Distance-based tests for homogeneity of multivariate dispersions. | Marti J Anderson | Biometrics | 2006 | 16542252 | Yes |
| 4115 | 1129 | 1129.0 | 31.8 | 31.8 | Neuronal circuitry for pain processing in the dorsal horn. | Andrew J Todd | Nat Rev Neurosci | 2010 | 21068766 | No |
| 4116 | 2257 | 1128.5 | 0.0 | 0.0 | Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. | L M Siegel, K J Monty | Biochim Biophys Acta | 1966 | 5329026 | Yes |
| 4117 | 1128 | 1128.0 | 29.0 | 29.0 | The Trk family of neurotrophin receptors. | M Barbacid | J Neurobiol | 1994 | 7852993 | No |
| 4118 | 1128 | 1128.0 | 27.1 | 27.1 | Current concepts of the pathogenesis of the acute coronary syndromes. | P Libby | Circulation | 2001 | 11457759 | No |
| 4119 | 1128 | 1128.0 | 28.5 | 28.5 | P-450 metabolites of arachidonic acid in the control of cardiovascular function. | Richard J Roman | Physiol Rev | 2002 | 11773611 | No |
| 4120 | 1128 | 1128.0 | 0.0 | 0.0 | Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. | A B Stavitsky | J Immunol | 1954 | 13163409 | Yes |
| 4121 | 1128 | 1128.0 | 29.9 | 29.9 | Sleep-dependent memory consolidation. | Robert Stickgold | Nature | 2005 | 16251952 | No |
| 4122 | 2256 | 1128.0 | 106.8 | 53.4 | The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications. | Yuanyuan Zhang, Zemin Zhang | Cell Mol Immunol | 2020 | 32612154 | No |
| 4123 | 2255 | 1127.5 | 58.6 | 29.3 | Breast cancer and hormone-replacement therapy in the Million Women Study. | Valerie Beral, | Lancet | 2003 | 12927427 | Yes |
| 4124 | 1127 | 1127.0 | 56.8 | 56.8 | Psychophysical scaling with applications in physical work and the perception of exertion. | G Borg | Scand J Work Environ Health | 1990 | 2345867 | Yes |
| 4125 | 1127 | 1127.0 | 23.0 | 23.0 | Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. | A S Baldwin | J Clin Invest | 2001 | 11160144 | No |
| 4126 | 1127 | 1127.0 | 27.6 | 27.6 | The primate basal ganglia: parallel and integrative networks. | Suzanne N Haber | J Chem Neuroanat | 2003 | 14729134 | No |
| 4127 | 1127 | 1127.0 | 57.3 | 57.3 | The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state. | Ergul Belge Kurutas | Nutr J | 2016 | 27456681 | No |
| 4128 | 2254 | 1127.0 | 97.9 | 49.0 | EMT Transition States during Tumor Progression and Metastasis. | Ievgenia Pastushenko, Cedric Blanpain | Trends Cell Biol | 2019 | 30594349 | No |
| 4129 | 2253 | 1126.5 | 66.6 | 33.3 | The spread of obesity in a large social network over 32 years. | Nicholas A Christakis, James H Fowler | N Engl J Med | 2007 | 17652652 | Yes |
| 4130 | 2252 | 1126.0 | 66.0 | 33.0 | A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. | J J Sedmak, S E Grossberg | Anal Biochem | 1977 | 68686 | Yes |
| 4131 | 2252 | 1126.0 | 63.3 | 31.6 | Frailty in relation to the accumulation of deficits. | Kenneth Rockwood, Arnold Mitnitski | J Gerontol A Biol Sci Med Sci | 2007 | 17634318 | No |
| 4132 | 1126 | 1126.0 | 29.7 | 29.7 | Trypan blue exclusion test of cell viability. | W Strober | Curr Protoc Immunol | 2001 | 18432654 | Yes |
| 4133 | 2252 | 1126.0 | 67.5 | 33.8 | Chronic hepatitis B: update 2009. | Anna S F Lok, Brian J McMahon | Hepatology | 2009 | 19714720 | Yes |
| 4134 | 2252 | 1126.0 | 60.3 | 30.1 | VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R. | Hanbo Chen, Paul C Boutros | BMC Bioinformatics | 2011 | 21269502 | Yes |
| 4135 | 2251 | 1125.5 | 0.0 | 0.0 | Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. | P Gold, S O Freedman | J Exp Med | 1965 | 14270243 | Yes |
| 4136 | 2251 | 1125.5 | 76.6 | 38.3 | The Li-ion rechargeable battery: a perspective. | John B Goodenough, Kyu-Sung Park | J Am Chem Soc | 2013 | 23294028 | Yes |
| 4137 | 3376 | 1125.3 | 119.1 | 39.7 | The triple aim: care, health, and cost. | Donald M Berwick, Thomas W Nolan, John Whittington | Health Aff (Millwood) | 2008 | 18474969 | Yes |
| 4138 | 3376 | 1125.3 | 99.0 | 33.0 | Electrical energy storage for the grid: a battery of choices. | Bruce Dunn, Haresh Kamath, Jean-Marie Tarascon | Science | 2011 | 22096188 | Yes |
| 4139 | 1125 | 1125.0 | 85.8 | 85.8 | Fundamental patterns of knowing in nursing. | B Carper | ANS Adv Nurs Sci | 1978 | 110216 | Yes |
| 4140 | 2250 | 1125.0 | 55.4 | 27.7 | The regulation and function of c-fos and other immediate early genes in the nervous system. | M Sheng, M E Greenberg | Neuron | 1990 | 1969743 | No |
| 4141 | 2250 | 1125.0 | 114.2 | 57.1 | Optimism, coping, and health: assessment and implications of generalized outcome expectancies. | M F Scheier, C S Carver | Health Psychol | 1985 | 4029106 | Yes |
| 4142 | 1125 | 1125.0 | 0.0 | 0.0 | Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. | R D Owen | Science | 1945 | 17755278 | Yes |
| 4143 | 2250 | 1125.0 | 83.6 | 41.8 | Using Big Data to Emulate a Target Trial When a Randomized Trial Is Not Available. | Miguel A Hernan, James M Robins | Am J Epidemiol | 2016 | 26994063 | Yes |
| 4144 | 4499 | 1124.8 | 156.4 | 39.1 | Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. | S Pellow, P Chopin, S E File, M Briley | J Neurosci Methods | 1985 | 2864480 | Yes |
| 4145 | 2249 | 1124.5 | 50.3 | 25.1 | Prediction of protein secondary structure at better than 70% accuracy. | B Rost, C Sander | J Mol Biol | 1993 | 8345525 | Yes |
| 4146 | 2249 | 1124.5 | 62.6 | 31.3 | Reactive oxygen species in cancer. | Geou-Yarh Liou, Peter Storz | Free Radic Res | 2010 | 20370557 | No |
| 4147 | 4497 | 1124.2 | 358.1 | 89.5 | AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings. | Jerome Eberhardt, Diogo Santos-Martins, Andreas F Tillack, Stefano Forli | J Chem Inf Model | 2021 | 34278794 | Yes |
| 4148 | 1124 | 1124.0 | 34.1 | 34.1 | Cell surface interactions with extracellular materials. | K M Yamada | Annu Rev Biochem | 1983 | 6351729 | No |
| 4149 | 1124 | 1124.0 | 22.2 | 22.2 | Regulation of transcription by MAP kinase cascades. | R Treisman | Curr Opin Cell Biol | 1996 | 8791420 | No |
| 4150 | 1124 | 1124.0 | 42.0 | 42.0 | Contaminant-stimulated reactive oxygen species production and oxidative damage in aquatic organisms. | D R Livingstone | Mar Pollut Bull | 2001 | 11525283 | No |
| 4151 | 4496 | 1124.0 | 134.2 | 33.5 | Prevalence and trends in obesity among US adults, 1999-2000. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L Johnson | JAMA | 2002 | 12365955 | Yes |
| 4152 | 4495 | 1123.8 | 121.1 | 30.3 | A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. | I Vermes, C Haanen, H Steffens-Nakken, C Reutelingsperger | J Immunol Methods | 1995 | 7622868 | Yes |
| 4153 | 1123 | 1123.0 | 0.0 | 0.0 | Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. | A R Midgley | Endocrinology | 1966 | 5950482 | Yes |
| 4154 | 1123 | 1123.0 | 37.3 | 37.3 | Behavior rating inventory of executive function. | Ida Sue Baron | Child Neuropsychol | 2000 | 11419452 | Yes |
| 4155 | 1123 | 1123.0 | 0.0 | 0.0 | A cytoarchitectonic atlas of the spinal cord in the cat. | B Rexed | J Comp Neurol | 1954 | 13163236 | Yes |
| 4156 | 1123 | 1123.0 | 38.6 | 38.6 | A novel automated method to measure total antioxidant response against potent free radical reactions. | Ozcan Erel | Clin Biochem | 2004 | 14725941 | Yes |
| 4157 | 1123 | 1123.0 | 33.8 | 33.8 | Lanthanide-based luminescent hybrid materials. | Koen Binnemans | Chem Rev | 2009 | 19650663 | Yes |
| 4158 | 3368 | 1122.7 | 102.9 | 34.3 | Immune checkpoint blockade: a common denominator approach to cancer therapy. | Suzanne L Topalian, Charles G Drake, Drew M Pardoll | Cancer Cell | 2015 | 25858804 | No |
| 4159 | 2245 | 1122.5 | 0.0 | 0.0 | Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. | R J Britten, D E Kohne | Science | 1968 | 4874239 | Yes |
| 4160 | 4490 | 1122.5 | 122.5 | 30.6 | An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. | Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H Burdette | Neuroimage | 2003 | 12880848 | Yes |
| 4161 | 2245 | 1122.5 | 82.2 | 41.1 | Coronaviruses: an overview of their replication and pathogenesis. | Anthony R Fehr, Stanley Perlman | Methods Mol Biol | 2015 | 25720466 | No |
| 4162 | 1122 | 1122.0 | 35.0 | 35.0 | Comparing evolvability and variability of quantitative traits. | D Houle | Genetics | 1992 | 1732160 | Yes |
| 4163 | 1122 | 1122.0 | 40.7 | 40.7 | Lipid peroxidation and antioxidants as biomarkers of tissue damage. | J M Gutteridge | Clin Chem | 1995 | 7497639 | No |
| 4164 | 1122 | 1122.0 | 35.9 | 35.9 | Investigating neighborhood and area effects on health. | A V Diez Roux | Am J Public Health | 2001 | 11684601 | No |
| 4165 | 1122 | 1122.0 | 21.5 | 21.5 | Cytokines in cancer pathogenesis and cancer therapy. | Glenn Dranoff | Nat Rev Cancer | 2004 | 14708024 | No |
| 4166 | 1122 | 1122.0 | 46.7 | 46.7 | Making sense of the meaning literature: an integrative review of meaning making and its effects on adjustment to stressful life events. | Crystal L Park | Psychol Bull | 2010 | 20192563 | No |
| 4167 | 1122 | 1122.0 | 24.9 | 24.9 | Cells of origin in cancer. | Jane E Visvader | Nature | 2011 | 21248838 | No |
| 4168 | 1122 | 1122.0 | 37.8 | 37.8 | The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer. | Donald C McMillan | Cancer Treat Rev | 2013 | 22995477 | No |
| 4169 | 2243 | 1121.5 | 46.2 | 23.1 | MAPK signal pathways in the regulation of cell proliferation in mammalian cells. | Wei Zhang, Hui Tu Liu | Cell Res | 2002 | 11942415 | No |
| 4170 | 2243 | 1121.5 | 49.2 | 24.6 | Drug repositioning: identifying and developing new uses for existing drugs. | Ted T Ashburn, Karl B Thor | Nat Rev Drug Discov | 2004 | 15286734 | No |
| 4171 | 2243 | 1121.5 | 54.5 | 27.2 | Antiinflammatory action of glucocorticoids--new mechanisms for old drugs. | Turk Rhen, John A Cidlowski | N Engl J Med | 2005 | 16236742 | No |
| 4172 | 4485 | 1121.2 | 152.4 | 38.1 | Prevalence and trends in obesity among US adults, 1999-2008. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R Curtin | JAMA | 2010 | 20071471 | Yes |
| 4173 | 1121 | 1121.0 | 49.4 | 49.4 | Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. | S Z Langer | Br J Pharmacol | 1977 | 20190 | No |
| 4174 | 1121 | 1121.0 | 38.6 | 38.6 | Chemoprevention of cancer. | L W Wattenberg | Cancer Res | 1985 | 3880665 | No |
| 4175 | 1121 | 1121.0 | 23.9 | 23.9 | ALSCRIPT: a tool to format multiple sequence alignments. | G J Barton | Protein Eng | 1993 | 8433969 | Yes |
| 4176 | 3363 | 1121.0 | 70.4 | 23.5 | X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. | Robert L Camp, Marisa Dolled-Filhart, David L Rimm | Clin Cancer Res | 2004 | 15534099 | Yes |
| 4177 | 1121 | 1121.0 | 26.3 | 26.3 | Immunosuppressive drugs for kidney transplantation. | Philip F Halloran | N Engl J Med | 2004 | 15616206 | No |
| 4178 | 3363 | 1121.0 | 89.3 | 29.8 | Stress and the brain: from adaptation to disease. | E Ron De Kloet, Marian Joels, Florian Holsboer | Nat Rev Neurosci | 2005 | 15891777 | No |
| 4179 | 1121 | 1121.0 | 22.1 | 22.1 | mTOR and cancer: insights into a complex relationship. | David M Sabatini | Nat Rev Cancer | 2006 | 16915295 | No |
| 4180 | 2242 | 1121.0 | 61.6 | 30.8 | Delivering nanomedicine to solid tumors. | Rakesh K Jain, Triantafyllos Stylianopoulos | Nat Rev Clin Oncol | 2010 | 20838415 | No |
| 4181 | 1121 | 1121.0 | 54.8 | 54.8 | Depression Is the Leading Cause of Disability Around the World. | M J Friedrich | JAMA | 2017 | 28418490 | Yes |
| 4182 | 4482 | 1120.5 | 111.9 | 28.0 | Permutation tests for joinpoint regression with applications to cancer rates. | H J Kim, M P Fay, E J Feuer, D N Midthune | Stat Med | 2000 | 10649300 | Yes |
| 4183 | 2241 | 1120.5 | 51.2 | 25.6 | Glycosylation in cellular mechanisms of health and disease. | Kazuaki Ohtsubo, Jamey D Marth | Cell | 2006 | 16959566 | No |
| 4184 | 14564 | 1120.3 | 435.3 | 33.5 | The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. | Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella, , | JAMA | 2003 | 12748199 | No |
| 4185 | 5601 | 1120.2 | 154.2 | 30.8 | 10-year follow-up of intensive glucose control in type 2 diabetes. | Rury R Holman, Sanjoy K Paul, M Angelyn Bethel, David R Matthews, H Andrew W Neil | N Engl J Med | 2008 | 18784090 | Yes |
| 4186 | 1120 | 1120.0 | 23.3 | 23.3 | mRNA stability in mammalian cells. | J Ross | Microbiol Rev | 1995 | 7565413 | No |
| 4187 | 1120 | 1120.0 | 29.8 | 29.8 | Neuropathology of Parkinson's disease. | L S Forno | J Neuropathol Exp Neurol | 1996 | 8786384 | No |
| 4188 | 1120 | 1120.0 | 26.9 | 26.9 | Neutrophils, from marrow to microbes. | Niels Borregaard | Immunity | 2010 | 21094463 | No |
| 4189 | 3360 | 1120.0 | 154.3 | 51.4 | Validation of the theoretical domains framework for use in behaviour change and implementation research. | James Cane, Denise O'Connor, Susan Michie | Implement Sci | 2012 | 22530986 | Yes |
| 4190 | 3359 | 1119.7 | 82.1 | 27.4 | Triple-negative breast cancer. | William D Foulkes, Ian E Smith, Jorge S Reis-Filho | N Engl J Med | 2010 | 21067385 | No |
| 4191 | 4478 | 1119.5 | 113.7 | 28.4 | The epidemiology of sepsis in the United States from 1979 through 2000. | Greg S Martin, David M Mannino, Stephanie Eaton, Marc Moss | N Engl J Med | 2003 | 12700374 | Yes |
| 4192 | 1119 | 1119.0 | 40.6 | 40.6 | A theory of visual attention. | C Bundesen | Psychol Rev | 1990 | 2247540 | Yes |
| 4193 | 1119 | 1119.0 | 30.3 | 30.3 | The chromosomal basis of human neoplasia. | J J Yunis | Science | 1983 | 6336310 | Yes |
| 4194 | 1119 | 1119.0 | 31.5 | 31.5 | Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading. | Michael Kjaer | Physiol Rev | 2004 | 15044685 | No |
| 4195 | 1119 | 1119.0 | 31.7 | 31.7 | The underappreciated role of muscle in health and disease. | Robert R Wolfe | Am J Clin Nutr | 2006 | 16960159 | No |
| 4196 | 1119 | 1119.0 | 30.6 | 30.6 | Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. | Satoshi Ikemoto | Brain Res Rev | 2007 | 17574681 | No |
| 4197 | 4472 | 1118.0 | 178.8 | 44.7 | Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. | K F Schulz, I Chalmers, R J Hayes, D G Altman | JAMA | 1995 | 7823387 | Yes |
| 4198 | 1118 | 1118.0 | 32.6 | 32.6 | Allostasis and allostatic load: implications for neuropsychopharmacology. | B S McEwen | Neuropsychopharmacology | 2000 | 10649824 | No |
| 4199 | 2236 | 1118.0 | 0.0 | 0.0 | Microdroplet Assay Of Human Serum Cytotoxins. | P I Terasaki, J D McClelland | Nature | 1964 | 14248725 | Yes |
| 4200 | 5590 | 1118.0 | 171.9 | 34.4 | Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation. | Gregory Y H Lip, Robby Nieuwlaat, Ron Pisters, Deirdre A Lane, Harry J G M Crijns | Chest | 2010 | 19762550 | Yes |
| 4201 | 1118 | 1118.0 | 38.5 | 38.5 | The brain basis of language processing: from structure to function. | Angela D Friederici | Physiol Rev | 2011 | 22013214 | No |
| 4202 | 1118 | 1118.0 | 37.7 | 37.7 | Isolation By Distance In Equilibrium And Non-Equilibrium Populations. | Montgomery Slatkin | Evolution | 1993 | 28568097 | Yes |
| 4203 | 1118 | 1118.0 | 57.7 | 57.7 | COVID-19: immunopathology and its implications for therapy. | Xuetao Cao | Nat Rev Immunol | 2020 | 32273594 | Yes |
| 4204 | 2234 | 1117.0 | 94.8 | 47.4 | Emotional processing of fear: exposure to corrective information. | E B Foa, M J Kozak | Psychol Bull | 1986 | 2871574 | Yes |
| 4205 | 1117 | 1117.0 | 27.6 | 27.6 | Marine viruses and their biogeochemical and ecological effects. | J A Fuhrman | Nature | 1999 | 10376593 | No |
| 4206 | 1117 | 1117.0 | 30.7 | 30.7 | Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate. | Randy L Buckner | Neuron | 2004 | 15450170 | No |
| 4207 | 1117 | 1117.0 | 33.9 | 33.9 | On the relationship between emotion and cognition. | Luiz Pessoa | Nat Rev Neurosci | 2008 | 18209732 | No |
| 4208 | 2233 | 1116.5 | 80.9 | 40.5 | Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. | A I Basbaum, H L Fields | Annu Rev Neurosci | 1984 | 6143527 | No |
| 4209 | 2233 | 1116.5 | 71.2 | 35.6 | Muscles, exercise and obesity: skeletal muscle as a secretory organ. | Bente K Pedersen, Mark A Febbraio | Nat Rev Endocrinol | 2012 | 22473333 | No |
| 4210 | 3349 | 1116.3 | 101.5 | 33.8 | Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences. | Charlotte Soneson, Michael I Love, Mark D Robinson | F1000Res | 2015 | 26925227 | Yes |
| 4211 | 7814 | 1116.3 | 674.2 | 96.3 | The psychological impact of quarantine and how to reduce it: rapid review of the evidence. | Samantha K Brooks, Rebecca K Webster, Louise E Smith, Lisa Woodland, Simon Wessely, Neil Greenberg, Gideon James Rubin | Lancet | 2020 | 32112714 | No |
| 4212 | 1116 | 1116.0 | 34.1 | 34.1 | The phylogenetic regression. | A Grafen | Philos Trans R Soc Lond B Biol Sci | 1989 | 2575770 | Yes |
| 4213 | 1116 | 1116.0 | 0.0 | 0.0 | Studies on histones. 7. Preparative methods for histone fractions from calf thymus. | E W Johns | Biochem J | 1964 | 5840387 | Yes |
| 4214 | 2232 | 1116.0 | 48.4 | 24.2 | The Hsp70 and Hsp60 chaperone machines. | B Bukau, A L Horwich | Cell | 1998 | 9476895 | No |
| 4215 | 1116 | 1116.0 | 0.0 | 0.0 | Some informational aspects of visual perception. | F Attneave | Psychol Rev | 1954 | 13167245 | Yes |
| 4216 | 1116 | 1116.0 | 19.3 | 19.3 | The concept of synthetic lethality in the context of anticancer therapy. | William G Kaelin | Nat Rev Cancer | 2005 | 16110319 | No |
| 4217 | 1116 | 1116.0 | 293.3 | 293.3 | Global incidence and mortality of severe fungal disease. | David W Denning | Lancet Infect Dis | 2024 | 38224705 | No |
| 4218 | 3347 | 1115.7 | 106.7 | 35.6 | Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. | Charalambos Vlachopoulos, Konstantinos Aznaouridis, Christodoulos Stefanadis | J Am Coll Cardiol | 2010 | 20338492 | Yes |
| 4219 | 2231 | 1115.5 | 67.4 | 33.7 | Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. | J M Reul, E R De Kloet | Endocrinology | 1985 | 2998738 | Yes |
| 4220 | 2231 | 1115.5 | 0.0 | 0.0 | Receptive fields of single neurones in the cat's striate cortex. | D H Hubel, T N Wiesel | J Physiol | 1959 | 14403679 | Yes |
| 4221 | 1115 | 1115.0 | 37.7 | 37.7 | A cognitive model of insomnia. | A G Harvey | Behav Res Ther | 2002 | 12186352 | No |
| 4222 | 1115 | 1115.0 | 37.2 | 37.2 | When does age-related cognitive decline begin? | Timothy A Salthouse | Neurobiol Aging | 2009 | 19231028 | Yes |
| 4223 | 6688 | 1114.7 | 184.7 | 30.8 | Ghrelin is a growth-hormone-releasing acylated peptide from stomach. | M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa | Nature | 1999 | 10604470 | Yes |
| 4224 | 2229 | 1114.5 | 78.3 | 39.1 | Population growth makes waves in the distribution of pairwise genetic differences. | A R Rogers, H Harpending | Mol Biol Evol | 1992 | 1316531 | Yes |
| 4225 | 2229 | 1114.5 | 70.8 | 35.4 | Excitatory amino acid transmitters. | J C Watkins, R H Evans | Annu Rev Pharmacol Toxicol | 1981 | 6112965 | No |
| 4226 | 3343 | 1114.3 | 90.5 | 30.2 | Separable dual-space Gaussian pseudopotentials. | S Goedecker, M Teter, J Hutter | Phys Rev B Condens Matter | 1996 | 9986014 | Yes |
| 4227 | 1114 | 1114.0 | 28.7 | 28.7 | Two distinct classes of carbohydrate-recognition domains in animal lectins. | K Drickamer | J Biol Chem | 1988 | 3290208 | No |
| 4228 | 1114 | 1114.0 | 24.2 | 24.2 | A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. | J Milbrandt | Science | 1987 | 3672127 | Yes |
| 4229 | 2228 | 1114.0 | 108.9 | 54.5 | Development, reliability, and validity of a dissociation scale. | E M Bernstein, F W Putnam | J Nerv Ment Dis | 1986 | 3783140 | Yes |
| 4230 | 1114 | 1114.0 | 42.6 | 42.6 | Molecular aspects of ligand binding to serum albumin. | U Kragh-Hansen | Pharmacol Rev | 1981 | 7027277 | No |
| 4231 | 1114 | 1114.0 | 21.7 | 21.7 | Tetraspanin functions and associated microdomains. | Martin E Hemler | Nat Rev Mol Cell Biol | 2005 | 16314869 | No |
| 4232 | 1114 | 1114.0 | 27.1 | 27.1 | Cooling, heating, generating power, and recovering waste heat with thermoelectric systems. | Lon E Bell | Science | 2008 | 18787160 | Yes |
| 4233 | 1114 | 1114.0 | 28.3 | 28.3 | Papillomaviruses in the causation of human cancers - a brief historical account. | Harald Zur Hausen | Virology | 2009 | 19135222 | No |
| 4234 | 1114 | 1114.0 | 34.4 | 34.4 | Gut feelings: the emerging biology of gut-brain communication. | Emeran A Mayer | Nat Rev Neurosci | 2011 | 21750565 | No |
| 4235 | 2226 | 1113.0 | 44.6 | 22.3 | In search of the 'missing self': MHC molecules and NK cell recognition. | H G Ljunggren, K Karre | Immunol Today | 1990 | 2201309 | No |
| 4236 | 1113 | 1113.0 | 26.7 | 26.7 | Selectins and their ligands: current concepts and controversies. | G S Kansas | Blood | 1996 | 8896391 | No |
Download as CSV