Unicorn Papers - Top cited papers from PUBMED

No.	Citations	EC_cit	RCR	EC_RCR	Title	Authors	Journal	Year	PMID	Article(?)
1	221215	221215.0	0.0	0.0	Cleavage of structural proteins during the assembly of the head of bacteriophage T4.	U K Laemmli	Nature	1970	5432063	Yes
2	167952	167952.0	0.0	0.0	A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.	M M Bradford	Anal Biochem	1976	942051	Yes
3	286741	71685.2	0.0	0.0	Protein measurement with the Folin phenol reagent.	O H Lowry, N J Rosebrough, A L Farr, R J Randall	J Biol Chem	1951	14907713	Yes
4	94114	47057.0	2431.91	1216.0	Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.	K J Livak, T D Schmittgen	Methods	2001	11846609	Yes
5	42819	42819.0	1458.44	1458.4	A short history of SHELX.	George M Sheldrick	Acta Crystallogr A	2008	18156677	Yes
6	33331	33331.0	1080.24	1080.2	Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.	T Mosmann	J Immunol Methods	1983	6606682	Yes
7	65110	32555.0	1973.95	987.0	Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.	P Chomczynski, N Sacchi	Anal Biochem	1987	2440339	Yes
8	30159	30159.0	0.0	0.0	Detection of specific sequences among DNA fragments separated by gel electrophoresis.	E M Southern	J Mol Biol	1975	1195397	Yes
9	25125	25125.0	0.0	0.0	The assessment and analysis of handedness: the Edinburgh inventory.	R C Oldfield	Neuropsychologia	1971	5146491	Yes
10	24561	24561.0	571.42	571.4	MicroRNAs: genomics, biogenesis, mechanism, and function.	David P Bartel	Cell	2004	14744438	No
11	23398	23398.0	0.0	0.0	A rating scale for depression.	M Hamilton	J Neurol Neurosurg Psychiatry	1960	14399272	Yes
12	22125	22125.0	694.78	694.8	Confidence Limits On Phylogenies: An Approach Using The Bootstrap.	Joseph Felsenstein	Evolution	1985	28561359	Yes
13	65272	21757.3	0.0	0.0	DNA sequencing with chain-terminating inhibitors.	F Sanger, S Nicklen, A R Coulson	Proc Natl Acad Sci U S A	1977	271968	Yes
14	21192	21192.0	530.45	530.5	MUSCLE: multiple sequence alignment with high accuracy and high throughput.	Robert C Edgar	Nucleic Acids Res	2004	15034147	Yes
15	21144	21144.0	505.53	505.5	A new mathematical model for relative quantification in real-time RT-PCR.	M W Pfaffl	Nucleic Acids Res	2001	11328886	Yes
16	19903	19903.0	0.0	0.0	The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.	E S Reynolds	J Cell Biol	1963	13986422	Yes
17	59598	19866.0	0.0	0.0	"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.	M F Folstein, S E Folstein, P R McHugh	J Psychiatr Res	1975	1202204	Yes
18	36484	18242.0	1131.44	565.7	The neighbor-joining method: a new method for reconstructing phylogenetic trees.	N Saitou, M Nei	Mol Biol Evol	1987	3447015	Yes
19	17965	17965.0	0.0	0.0	Tissue sulfhydryl groups.	G L Ellman	Arch Biochem Biophys	1959	13650640	Yes
20	53102	17700.7	0.0	0.0	Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.	H Towbin, T Staehelin, J Gordon	Proc Natl Acad Sci U S A	1979	388439	Yes
21	16799	16799.0	0.0	0.0	Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins.	B J Davis	Ann N Y Acad Sci	1964	14240539	Yes
22	33262	16631.0	1615.14	807.6	Statistical methods for assessing agreement between two methods of clinical measurement.	J M Bland, D G Altman	Lancet	1986	2868172	Yes
23	16516	16516.0	0.0	0.0	High resolution two-dimensional electrophoresis of proteins.	P H O'Farrell	J Biol Chem	1975	236308	Yes
24	16383	16383.0	582.86	582.9	Density-functional exchange-energy approximation with correct asymptotic behavior.	Becke	Phys Rev A Gen Phys	1988	9900728	Yes
25	16019	16019.0	419.51	419.5	Atherosclerosis--an inflammatory disease.	R Ross	N Engl J Med	1999	9887164	No
26	15897	15897.0	0.0	0.0	A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.	K Burton	Biochem J	1956	13293190	Yes
27	31550	15775.0	1139.73	569.9	Hallmarks of cancer: the next generation.	Douglas Hanahan, Robert A Weinberg	Cell	2011	21376230	No
28	30435	15217.5	0.0	0.0	A rapid method of total lipid extraction and purification.	E G Bligh, W J Dyer	Can J Biochem Physiol	1959	13671378	Yes
29	15192	15192.0	566.59	566.6	A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.	M Kimura	J Mol Evol	1980	7463489	Yes
30	29014	14507.0	0.0	0.0	The measurement of observer agreement for categorical data.	J R Landis, G G Koch	Biometrics	1977	843571	Yes
31	43167	14389.0	1248.7	416.2	CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.	J D Thompson, D G Higgins, T J Gibson	Nucleic Acids Res	1994	7984417	Yes
32	41227	13742.3	0.0	0.0	A simple method for the isolation and purification of total lipides from animal tissues.	J Folch, M Lees, G H Sloane Stanley	J Biol Chem	1957	13428781	Yes
33	13259	13259.0	368.46	368.5	MicroRNAs: target recognition and regulatory functions.	David P Bartel	Cell	2009	19167326	No
34	12775	12775.0	543.37	543.4	A power primer.	J Cohen	Psychol Bull	1992	19565683	Yes
35	12741	12741.0	0.0	0.0	Phosphorus assay in column chromatography.	G R Bartlett	J Biol Chem	1959	13641241	Yes
36	25272	12636.0	978.01	489.0	Meta-analysis in clinical trials.	R DerSimonian, N Laird	Control Clin Trials	1986	3802833	Yes
37	12485	12485.0	373.75	373.8	Projector augmented-wave method.	Blöchl	Phys Rev B Condens Matter	1994	9976227	Yes
38	24662	12331.0	1031.2	515.6	The hospital anxiety and depression scale.	A S Zigmond, R P Snaith	Acta Psychiatr Scand	1983	6880820	Yes
39	11866	11866.0	472.57	472.6	Catalase in vitro.	H Aebi	Methods Enzymol	1984	6727660	Yes
40	11222	11222.0	602.55	602.5	RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.	Alexandros Stamatakis	Bioinformatics	2014	24451623	Yes
41	54917	10983.4	1591.52	318.3	Basic local alignment search tool.	S F Altschul, W Gish, W Miller, E W Myers, D J Lipman	J Mol Biol	1990	2231712	Yes
42	21950	10975.0	935.25	467.6	The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.	J E Ware, C D Sherbourne	Med Care	1992	1593914	Yes
43	21561	10780.5	560.16	280.1	A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.	A P Feinberg, B Vogelstein	Anal Biochem	1983	6312838	Yes
44	32132	10710.7	1005.99	335.3	Generalized Gradient Approximation Made Simple.	Perdew, Burke, Ernzerhof	Phys Rev Lett	1996	10062328	Yes
45	21292	10646.0	473.84	236.9	Coot: model-building tools for molecular graphics.	Paul Emsley, Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2004	15572765	Yes
46	10307	10307.0	0.0	0.0	Improvements in epoxy resin embedding methods.	J H Luft	J Biophys Biochem Cytol	1961	13764136	Yes
47	10285	10285.0	348.23	348.2	Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).	J F Kurtzke	Neurology	1983	6685237	Yes
48	20198	10099.0	568.36	284.2	Fast and accurate short read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2009	19451168	Yes
49	10022	10022.0	397.12	397.1	Structure validation in chemical crystallography.	Anthony L Spek	Acta Crystallogr D Biol Crystallogr	2009	19171970	Yes
50	20008	10004.0	0.0	0.0	The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.	K Weber, M Osborn	J Biol Chem	1969	5806584	Yes
51	29779	9926.3	1091.42	363.8	Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density.	Lee, Yang, Parr	Phys Rev B Condens Matter	1988	9944570	Yes
52	9915	9915.0	0.0	0.0	The genetics of Caenorhabditis elegans.	S Brenner	Genetics	1974	4366476	Yes
53	9849	9849.0	305.95	305.9	The Psychophysics Toolbox.	D H Brainard	Spat Vis	1997	9176952	Yes
54	19592	9796.0	443.32	221.7	[20] Processing of X-ray diffraction data collected in oscillation mode.	Zbyszek Otwinowski, Wladek Minor	Methods Enzymol	1997	27799103	Yes
55	9685	9685.0	360.87	360.9	Search and clustering orders of magnitude faster than BLAST.	Robert C Edgar	Bioinformatics	2010	20709691	Yes
56	9518	9518.0	278.94	278.9	Xds.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124692	Yes
57	9514	9514.0	0.0	0.0	Self-efficacy: toward a unifying theory of behavioral change.	A Bandura	Psychol Rev	1977	847061	Yes
58	9439	9439.0	325.1	325.1	Banting lecture 1988. Role of insulin resistance in human disease.	G M Reaven	Diabetes	1988	3056758	No
59	9248	9248.0	269.02	269.0	Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.	P S Thomas	Proc Natl Acad Sci U S A	1980	6159641	Yes
60	18469	9234.5	690.94	345.5	Fast gapped-read alignment with Bowtie 2.	Ben Langmead, Steven L Salzberg	Nat Methods	2012	22388286	Yes
61	9054	9054.0	241.13	241.1	Studies on transformation of Escherichia coli with plasmids.	D Hanahan	J Mol Biol	1983	6345791	Yes
62	18083	9041.5	475.52	237.8	A simple method for displaying the hydropathic character of a protein.	J Kyte, R F Doolittle	J Mol Biol	1982	7108955	Yes
63	9040	9040.0	357.15	357.1	A new method for measuring daytime sleepiness: the Epworth sleepiness scale.	M W Johns	Sleep	1991	1798888	Yes
64	9028	9028.0	260.3	260.3	The pathogenesis of atherosclerosis: a perspective for the 1990s.	R Ross	Nature	1993	8479518	No
65	17854	8927.0	815.15	407.6	The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations.	R M Baron, D A Kenny	J Pers Soc Psychol	1986	3806354	Yes
66	8924	8924.0	235.53	235.5	Integrins: versatility, modulation, and signaling in cell adhesion.	R O Hynes	Cell	1992	1555235	No
67	8618	8618.0	600.89	600.9	Crystal structure refinement with SHELXL.	George M Sheldrick	Acta Crystallogr C Struct Chem	2015	25567568	Yes
68	17198	8599.0	490.48	245.2	Quantifying heterogeneity in a meta-analysis.	Julian P T Higgins, Simon G Thompson	Stat Med	2002	12111919	Yes
69	8484	8484.0	187.56	187.6	Mfold web server for nucleic acid folding and hybridization prediction.	Michael Zuker	Nucleic Acids Res	2003	12824337	Yes
70	8387	8387.0	239.79	239.8	Evolutionary trees from DNA sequences: a maximum likelihood approach.	J Felsenstein	J Mol Evol	1981	7288891	Yes
71	8335	8335.0	232.38	232.4	RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models.	Alexandros Stamatakis	Bioinformatics	2006	16928733	Yes
72	8208	8208.0	0.0	0.0	On the origin of cancer cells.	O Warburg	Science	1956	13298683	Yes
73	8199	8199.0	260.55	260.6	Vitamin D deficiency.	Michael F Holick	N Engl J Med	2007	17634462	No
74	8075	8075.0	174.16	174.2	Linear models and empirical bayes methods for assessing differential expression in microarray experiments.	Gordon K Smyth	Stat Appl Genet Mol Biol	2004	16646809	Yes
75	16147	8073.5	474.76	237.4	Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set.	Kresse, Furthmüller	Phys Rev B Condens Matter	1996	9984901	Yes
76	16099	8049.5	353.83	176.9	The hallmarks of cancer.	D Hanahan, R A Weinberg	Cell	2000	10647931	No
77	7975	7975.0	0.0	0.0	Solvent content of protein crystals.	B W Matthews	J Mol Biol	1968	5700707	Yes
78	7902	7902.0	356.31	356.3	Psychophysical bases of perceived exertion.	G A Borg	Med Sci Sports Exerc	1982	7154893	Yes
79	23566	7855.3	631.68	210.6	VMD: visual molecular dynamics.	W Humphrey, A Dalke, K Schulten	J Mol Graph	1996	8744570	Yes
80	7764	7764.0	218.44	218.4	The role of protein kinase C in cell surface signal transduction and tumour promotion.	Y Nishizuka	Nature	1984	6232463	No
81	7731	7731.0	217.92	217.9	"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.	W N Burnette	Anal Biochem	1981	6266278	Yes
82	30845	7711.2	938.26	234.6	Measuring inconsistency in meta-analyses.	Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman	BMJ	2003	12958120	No
83	7689	7689.0	171.64	171.6	The functions of animal microRNAs.	Victor Ambros	Nature	2004	15372042	No
84	7669	7669.0	0.0	0.0	A simplification of the protein assay method of Lowry et al. which is more generally applicable.	G L Peterson	Anal Biochem	1977	603028	Yes
85	7561	7561.0	0.0	0.0	Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.	J R Vane	Nat New Biol	1971	5284360	Yes
86	7442	7442.0	0.0	0.0	Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris.	D I Arnon	Plant Physiol	1949	16654194	Yes
87	7387	7387.0	201.97	202.0	Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.	M C Hochberg	Arthritis Rheum	1997	9324032	Yes
88	14681	7340.5	349.52	174.8	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.	Kazutoshi Takahashi, Shinya Yamanaka	Cell	2006	16904174	Yes
89	7280	7280.0	214.95	214.9	Semiempirical GGA-type density functional constructed with a long-range dispersion correction.	Stefan Grimme	J Comput Chem	2006	16955487	Yes
90	7226	7226.0	0.0	0.0	A low-viscosity epoxy resin embedding medium for electron microscopy.	A R Spurr	J Ultrastruct Res	1969	4887011	Yes
91	28785	7196.2	1113.69	278.4	A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.	M E Charlson, P Pompei, K L Ales, C R MacKenzie	J Chronic Dis	1987	3558716	Yes
92	21352	7117.3	609.33	203.1	Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nat Protoc	2009	19131956	Yes
93	7060	7060.0	0.0	0.0	Tumor angiogenesis: therapeutic implications.	J Folkman	N Engl J Med	1971	4938153	No
94	14026	7013.0	357.57	178.8	MrBayes 3: Bayesian phylogenetic inference under mixed models.	Fredrik Ronquist, John P Huelsenbeck	Bioinformatics	2003	12912839	Yes
95	6993	6993.0	194.1	194.1	TreeView: an application to display phylogenetic trees on personal computers.	R D Page	Comput Appl Biosci	1996	8902363	Yes
96	6992	6992.0	0.0	0.0	Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.	A Böyum	Scand J Clin Lab Invest Suppl	1968	4179068	Yes
97	27920	6980.0	1221.42	305.4	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	PLoS Med	2009	19621072	No
98	20645	6881.7	0.0	0.0	Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.	W T Friedewald, R I Levy, D S Fredrickson	Clin Chem	1972	4337382	Yes
99	48011	6858.7	1273.38	181.9	Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.	S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman	Nucleic Acids Res	1997	9254694	No
100	6800	6800.0	207.57	207.6	AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.	R W Cox	Comput Biomed Res	1996	8812068	Yes
101	6797	6797.0	0.0	0.0	The thiobarbituric acid assay of sialic acids.	L Warren	J Biol Chem	1959	13672998	Yes
102	26999	6749.8	904.69	226.2	Bias in meta-analysis detected by a simple, graphical test.	M Egger, G Davey Smith, M Schneider, C Minder	BMJ	1997	9310563	Yes
103	6733	6733.0	183.64	183.6	The steroid and thyroid hormone receptor superfamily.	R M Evans	Science	1988	3283939	No
104	20150	6716.7	800.05	266.7	NIH Image to ImageJ: 25 years of image analysis.	Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri	Nat Methods	2012	22930834	No
105	13421	6710.5	0.0	0.0	Continuous cultures of fused cells secreting antibody of predefined specificity.	G Köhler, C Milstein	Nature	1975	1172191	Yes
106	20017	6672.3	572.25	190.8	A new generation of Ca2+ indicators with greatly improved fluorescence properties.	G Grynkiewicz, M Poenie, R Y Tsien	J Biol Chem	1985	3838314	Yes
107	6672	6672.0	232.23	232.2	The blockade of immune checkpoints in cancer immunotherapy.	Drew M Pardoll	Nat Rev Cancer	2012	22437870	No
108	13341	6670.5	384.95	192.5	Analyzing real-time PCR data by the comparative C(T) method.	Thomas D Schmittgen, Kenneth J Livak	Nat Protoc	2008	18546601	Yes
109	6641	6641.0	154.78	154.8	Chromatin modifications and their function.	Tony Kouzarides	Cell	2007	17320507	No
110	13268	6634.0	287.55	143.8	Processing of X-ray diffraction data collected in oscillation mode.	Z Otwinowski, W Minor	Methods Enzymol	1997	27754618	Yes
111	6617	6617.0	264.89	264.9	Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses.	Andreas Stang	Eur J Epidemiol	2010	20652370	Yes
112	6579	6579.0	178.02	178.0	Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.	F Tajima	Genetics	1989	2513255	Yes
113	6564	6564.0	172.43	172.4	PAML 4: phylogenetic analysis by maximum likelihood.	Ziheng Yang	Mol Biol Evol	2007	17483113	Yes
114	6521	6521.0	179.72	179.7	Canonical dynamics: Equilibrium phase-space distributions.	Hoover	Phys Rev A Gen Phys	1985	9895674	Yes
115	6520	6520.0	313.09	313.1	Comparative fit indexes in structural models.	P M Bentler	Psychol Bull	1990	2320703	Yes
116	19484	6494.7	879.51	293.2	Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.	Michael I Love, Wolfgang Huber, Simon Anders	Genome Biol	2014	25516281	Yes
117	6488	6488.0	172.76	172.8	Adhesion receptors of the immune system.	T A Springer	Nature	1990	1974032	No
118	12843	6421.5	297.58	148.8	Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana.	S J Clough, A F Bent	Plant J	1998	10069079	Yes
119	6363	6363.0	169.36	169.4	Angiogenesis in cancer, vascular, rheumatoid and other disease.	J Folkman	Nat Med	1995	7584949	No
120	6360	6360.0	0.0	0.0	The assessment of anxiety states by rating.	M Hamilton	Br J Med Psychol	1959	13638508	Yes
121	6352	6352.0	129.9	129.9	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel	Proc Natl Acad Sci U S A	1985	3881765	Yes
122	6334	6334.0	165.15	165.2	Fast robust automated brain extraction.	Stephen M Smith	Hum Brain Mapp	2002	12391568	No
123	12650	6325.0	0.0	0.0	Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.	Y Cheng, W H Prusoff	Biochem Pharmacol	1973	4202581	Yes
124	6309	6309.0	215.71	215.7	Density-functional approximation for the correlation energy of the inhomogeneous electron gas.	Perdew	Phys Rev B Condens Matter	1986	9938299	Yes
125	12492	6246.0	0.0	0.0	Statistical aspects of the analysis of data from retrospective studies of disease.	N Mantel, W Haenszel	J Natl Cancer Inst	1959	13655060	Yes
126	6232	6232.0	193.71	193.7	The VideoToolbox software for visual psychophysics: transforming numbers into movies.	D G Pelli	Spat Vis	1997	9176953	Yes
127	6149	6149.0	205.23	205.2	Ethical guidelines for investigations of experimental pain in conscious animals.	Manfred Zimmermann	Pain	1983	6877845	No
128	6132	6132.0	135.79	135.8	p53, the cellular gatekeeper for growth and division.	A J Levine	Cell	1997	9039259	No
129	12216	6108.0	272.31	136.2	KEGG: kyoto encyclopedia of genes and genomes.	M Kanehisa, S Goto	Nucleic Acids Res	2000	10592173	Yes
130	12185	6092.5	0.0	0.0	A rapid alkaline extraction procedure for screening recombinant plasmid DNA.	H C Birnboim, J Doly	Nucleic Acids Res	1979	388356	Yes
131	6082	6082.0	174.27	174.3	Apoptosis: a review of programmed cell death.	Susan Elmore	Toxicol Pathol	2007	17562483	No
132	12074	6037.0	565.22	282.6	MAFFT multiple sequence alignment software version 7: improvements in performance and usability.	Kazutaka Katoh, Daron M Standley	Mol Biol Evol	2013	23329690	Yes
133	6012	6012.0	150.52	150.5	Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm.	T A Springer	Cell	1994	7507411	No
134	23981	5995.2	0.0	0.0	Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.	J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter	Biochemistry	1979	518835	Yes
135	5933	5933.0	152.47	152.5	Inositol trisphosphate and calcium signalling.	M J Berridge	Nature	1993	8381210	No
136	11831	5915.5	0.0	0.0	Prediction of creatinine clearance from serum creatinine.	D W Cockcroft, M H Gault	Nephron	1976	1244564	Yes
137	5911	5911.0	152.23	152.2	G proteins: transducers of receptor-generated signals.	A G Gilman	Annu Rev Biochem	1987	3113327	No
138	17582	5860.7	863.46	287.8	Trimmomatic: a flexible trimmer for Illumina sequence data.	Anthony M Bolger, Marc Lohse, Bjoern Usadel	Bioinformatics	2014	24695404	Yes
139	5840	5840.0	193.18	193.2	The Clinical Dementia Rating (CDR): current version and scoring rules.	J C Morris	Neurology	1993	8232972	Yes
140	5817	5817.0	121.73	121.7	Integrins: bidirectional, allosteric signaling machines.	Richard O Hynes	Cell	2002	12297042	No
141	5791	5791.0	133.7	133.7	Inflammation in atherosclerosis.	Peter Libby	Nature	2002	12490960	No
142	5768	5768.0	282.26	282.3	Investigation of the freely available easy-to-use software 'EZR' for medical statistics.	Y Kanda	Bone Marrow Transplant	2013	23208313	Yes
143	11478	5739.0	0.0	0.0	Intraclass correlations: uses in assessing rater reliability.	P E Shrout, J L Fleiss	Psychol Bull	1979	18839484	No
144	11475	5737.5	0.0	0.0	The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature.	T Omura, R Sato	J Biol Chem	1964	14209971	Yes
145	5689	5689.0	144.37	144.4	Inflammation, atherosclerosis, and coronary artery disease.	Göran K Hansson	N Engl J Med	2005	15843671	No
146	16990	5663.3	1362.4	454.1	MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.	Sudhir Kumar, Glen Stecher, Koichiro Tamura	Mol Biol Evol	2016	27004904	Yes
147	5629	5629.0	144.59	144.6	Apoptosis in the pathogenesis and treatment of disease.	C B Thompson	Science	1995	7878464	No
148	11249	5624.5	401.86	200.9	The meaning and use of the area under a receiver operating characteristic (ROC) curve.	J A Hanley, B J McNeil	Radiology	1982	7063747	Yes
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2989	2142	1071.0	71.15<

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