Unicorn Papers - Top cited papers from PUBMED

No.	Citations	EC_cit	RCR	EC_RCR	Title	Authors	Journal	Year	PMID	Article(?)
1	167006	167006.0	0.0	0.0	Cleavage of structural proteins during the assembly of the head of bacteriophage T4.	U K Laemmli	Nature	1970	5432063	Yes
2	131320	131320.0	0.0	0.0	A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.	M M Bradford	Anal Biochem	1976	942051	Yes
3	193032	48258.0	0.0	0.0	Protein measurement with the Folin phenol reagent.	O H LOWRY, N J ROSEBROUGH, A L FARR, R J RANDALL	J Biol Chem	1951	14907713	Yes
4	89376	44688.0	2473.13	1236.6	Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.	K J Livak, T D Schmittgen	Methods	2001	11846609	Yes
5	41283	41283.0	1491.53	1491.5	A short history of SHELX.	George M Sheldrick	Acta Crystallogr A	2008	18156677	Yes
6	28078	28078.0	1139.86	1139.9	Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.	T Mosmann	J Immunol Methods	1983	6606682	Yes
7	23354	23354.0	0.0	0.0	Detection of specific sequences among DNA fragments separated by gel electrophoresis.	E M Southern	J Mol Biol	1975	1195397	Yes
8	23158	23158.0	548.09	548.1	MicroRNAs: genomics, biogenesis, mechanism, and function.	David P Bartel	Cell	2004	14744438	No
9	22730	22730.0	0.0	0.0	The assessment and analysis of handedness: the Edinburgh inventory.	R C Oldfield	Neuropsychologia	1971	5146491	Yes
10	45381	22690.5	1802.32	901.2	Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.	P Chomczynski, N Sacchi	Anal Biochem	1987	2440339	Yes
11	20240	20240.0	521.27	521.3	MUSCLE: multiple sequence alignment with high accuracy and high throughput.	Robert C Edgar	Nucleic Acids Res	2004	15034147	Yes
12	20219	20219.0	510.57	510.6	A new mathematical model for relative quantification in real-time RT-PCR.	M W Pfaffl	Nucleic Acids Res	2001	11328886	Yes
13	18147	18147.0	0.0	0.0	A rating scale for depression.	M HAMILTON	J Neurol Neurosurg Psychiatry	1960	14399272	Yes
14	49679	16559.7	0.0	0.0	"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.	M F Folstein, S E Folstein, P R McHugh	J Psychiatr Res	1975	1202204	Yes
15	32250	16125.0	1181.94	591.0	The neighbor-joining method: a new method for reconstructing phylogenetic trees.	N Saitou, M Nei	Mol Biol Evol	1987	3447015	Yes
16	15933	15933.0	655.6	655.6	Density-functional exchange-energy approximation with correct asymptotic behavior.	Becke	Phys Rev A Gen Phys	1988	9900728	Yes
17	45445	15148.3	0.0	0.0	DNA sequencing with chain-terminating inhibitors.	F Sanger, S Nicklen, A R Coulson	Proc Natl Acad Sci U S A	1977	271968	Yes
18	30284	15142.0	1129.16	564.6	Hallmarks of cancer: the next generation.	Douglas Hanahan, Robert A Weinberg	Cell	2011	21376230	No
19	14796	14796.0	542.8	542.8	CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP.	Joseph Felsenstein	Evolution	1985	28561359	Yes
20	14382	14382.0	0.0	0.0	The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.	E S REYNOLDS	J Cell Biol	1963	13986422	Yes
21	14021	14021.0	0.0	0.0	Tissue sulfhydryl groups.	G L ELLMAN	Arch Biochem Biophys	1959	13650640	Yes
22	13947	13947.0	407.62	407.6	Atherosclerosis--an inflammatory disease.	R Ross	N Engl J Med	1999	9887164	No
23	27546	13773.0	1625.48	812.7	Statistical methods for assessing agreement between two methods of clinical measurement.	J M Bland, D G Altman	Lancet	1986	2868172	Yes
24	13549	13549.0	593.54	593.5	A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.	M Kimura	J Mol Evol	1980	7463489	Yes
25	25828	12914.0	0.0	0.0	The measurement of observer agreement for categorical data.	J R Landis, G G Koch	Biometrics	1977	843571	Yes
26	38651	12883.7	1277.42	425.8	CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.	J D Thompson, D G Higgins, T J Gibson	Nucleic Acids Res	1994	7984417	Yes
27	12641	12641.0	355.72	355.7	MicroRNAs: target recognition and regulatory functions.	David P Bartel	Cell	2009	19167326	No
28	11971	11971.0	367.58	367.6	Projector augmented-wave method.	Blöchl	Phys Rev B Condens Matter	1994	9976227	Yes
29	35746	11915.3	0.0	0.0	Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.	H Towbin, T Staehelin, J Gordon	Proc Natl Acad Sci U S A	1979	388439	Yes
30	11673	11673.0	0.0	0.0	High resolution two-dimensional electrophoresis of proteins.	P H O'Farrell	J Biol Chem	1975	236308	Yes
31	23266	11633.0	0.0	0.0	A rapid method of total lipid extraction and purification.	E G BLIGH, W J DYER	Can J Biochem Physiol	1959	13671378	Yes
32	23064	11532.0	1033.35	516.7	Meta-analysis in clinical trials.	R DerSimonian, N Laird	Control Clin Trials	1986	3802833	Yes
33	22245	11122.5	1105.2	552.6	The hospital anxiety and depression scale.	A S Zigmond, R P Snaith	Acta Psychiatr Scand	1983	6880820	Yes
34	11076	11076.0	569.42	569.4	A power primer.	J Cohen	Psychol Bull	1992	19565683	Yes
35	10621	10621.0	0.0	0.0	DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.	B J DAVIS	Ann N Y Acad Sci	1964	14240539	Yes
36	10535	10535.0	501.34	501.3	Catalase in vitro.	H Aebi	Methods Enzymol	1984	6727660	Yes
37	10472	10472.0	583.44	583.4	RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.	Alexandros Stamatakis	Bioinformatics	2014	24451623	Yes
38	30969	10323.0	1027.63	342.5	Generalized Gradient Approximation Made Simple.	Perdew, Burke, Ernzerhof	Phys Rev Lett	1996	10062328	Yes
39	20123	10061.5	459.76	229.9	Coot: model-building tools for molecular graphics.	Paul Emsley, Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2004	15572765	Yes
40	10004	10004.0	0.0	0.0	A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.	K BURTON	Biochem J	1956	13293190	Yes
41	29876	9958.7	0.0	0.0	A simple method for the isolation and purification of total lipides from animal tissues.	J FOLCH, M LEES, G H SLOANE STANLEY	J Biol Chem	1957	13428781	Yes
42	28946	9648.7	1229.51	409.8	Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density.	Lee, Yang, Parr	Phys Rev B Condens Matter	1988	9944570	Yes
43	19282	9641.0	460.47	230.2	[20] Processing of X-ray diffraction data collected in oscillation mode.	Zbyszek Otwinowski, Wladek Minor	Methods Enzymol	1997	27799103	Yes
44	48099	9619.8	1594.9	319.0	Basic local alignment search tool.	S F Altschul, W Gish, W Miller, E W Myers, D J Lipman	J Mol Biol	1990	2231712	Yes
45	19236	9618.0	540.82	270.4	Fast and accurate short read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2009	19451168	Yes
46	9615	9615.0	401.87	401.9	Structure validation in chemical crystallography.	Anthony L Spek	Acta Crystallogr D Biol Crystallogr	2009	19171970	Yes
47	19061	9530.5	1012.17	506.1	The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.	J E Ware, C D Sherbourne	Med Care	1992	1593914	Yes
48	9287	9287.0	352.94	352.9	Search and clustering orders of magnitude faster than BLAST.	Robert C Edgar	Bioinformatics	2010	20709691	Yes
49	9103	9103.0	0.0	0.0	The genetics of Caenorhabditis elegans.	S Brenner	Genetics	1974	4366476	Yes
50	9088	9088.0	273.83	273.8	XDS.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124692	Yes
51	17301	8650.5	656.12	328.1	Fast gapped-read alignment with Bowtie 2.	Ben Langmead, Steven L Salzberg	Nat Methods	2012	22388286	Yes
52	8636	8636.0	352.61	352.6	Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).	J F Kurtzke	Neurology	1983	6685237	Yes
53	8597	8597.0	285.5	285.5	The Psychophysics Toolbox.	D H Brainard	Spat Vis	1997	9176952	Yes
54	8424	8424.0	0.0	0.0	Phosphorus assay in column chromatography.	G R BARTLETT	J Biol Chem	1959	13641241	Yes
55	8135	8135.0	185.78	185.8	Mfold web server for nucleic acid folding and hybridization prediction.	Michael Zuker	Nucleic Acids Res	2003	12824337	Yes
56	8019	8019.0	370.34	370.3	A new method for measuring daytime sleepiness: the Epworth sleepiness scale.	M W Johns	Sleep	1991	1798888	Yes
57	7995	7995.0	228.45	228.4	RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models.	Alexandros Stamatakis	Bioinformatics	2006	16928733	Yes
58	7985	7985.0	173.18	173.2	Linear models and empirical bayes methods for assessing differential expression in microarray experiments.	Gordon K Smyth	Stat Appl Genet Mol Biol	2004	16646809	Yes
59	7960	7960.0	584.76	584.8	Crystal structure refinement with SHELXL.	George M Sheldrick	Acta Crystallogr C Struct Chem	2015	25567568	Yes
60	15886	7943.0	504.46	252.2	Quantifying heterogeneity in a meta-analysis.	Julian P T Higgins, Simon G Thompson	Stat Med	2002	12111919	Yes
61	15839	7919.5	366.62	183.3	The hallmarks of cancer.	D Hanahan, R A Weinberg	Cell	2000	10647931	No
62	15724	7862.0	574.46	287.2	A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.	A P Feinberg, B Vogelstein	Anal Biochem	1983	6312838	Yes
63	7799	7799.0	266.77	266.8	Studies on transformation of Escherichia coli with plasmids.	D Hanahan	J Mol Biol	1983	6345791	Yes
64	15469	7734.5	461.44	230.7	Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set.	Kresse, Furthmüller	Phys Rev B Condens Matter	1996	9984901	Yes
65	7731	7731.0	0.0	0.0	Self-efficacy: toward a unifying theory of behavioral change.	A Bandura	Psychol Rev	1977	847061	Yes
66	7682	7682.0	258.37	258.4	Evolutionary trees from DNA sequences: a maximum likelihood approach.	J Felsenstein	J Mol Evol	1981	7288891	Yes
67	15015	7507.5	796.7	398.4	The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations.	R M Baron, D A Kenny	J Pers Soc Psychol	1986	3806354	Yes
68	7458	7458.0	253.39	253.4	Vitamin D deficiency.	Michael F Holick	N Engl J Med	2007	17634462	No
69	14890	7445.0	501.21	250.6	A simple method for displaying the hydropathic character of a protein.	J Kyte, R F Doolittle	J Mol Biol	1982	7108955	Yes
70	21991	7330.3	620.25	206.8	VMD: visual molecular dynamics.	W Humphrey, A Dalke, K Schulten	J Mol Graph	1996	8744570	Yes
71	7249	7249.0	259.14	259.1	The pathogenesis of atherosclerosis: a perspective for the 1990s.	R Ross	Nature	1993	8479518	No
72	7235	7235.0	162.81	162.8	The functions of animal microRNAs.	Victor Ambros	Nature	2004	15372042	No
73	28844	7211.0	974.74	243.7	Measuring inconsistency in meta-analyses.	Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman	BMJ	2003	12958120	No
74	7191	7191.0	0.0	0.0	On the origin of cancer cells.	O WARBURG	Science	1956	13298683	Yes
75	7063	7063.0	216.56	216.6	Semiempirical GGA-type density functional constructed with a long-range dispersion correction.	Stefan Grimme	J Comput Chem	2006	16955487	Yes
76	7019	7019.0	291.85	291.9	Banting lecture 1988. Role of insulin resistance in human disease.	G M Reaven	Diabetes	1988	3056758	No
77	6969	6969.0	0.0	0.0	Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.	A Böyum	Scand J Clin Lab Invest Suppl	1968	4179068	Yes
78	13864	6932.0	330.68	165.3	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.	Kazutoshi Takahashi, Shinya Yamanaka	Cell	2006	16904174	Yes
79	6905	6905.0	0.0	0.0	Improvements in epoxy resin embedding methods.	J H LUFT	J Biophys Biochem Cytol	1961	13764136	Yes
80	20437	6812.3	590.54	196.8	Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nat Protoc	2009	19131956	Yes
81	6777	6777.0	219.48	219.5	Integrins: versatility, modulation, and signaling in cell adhesion.	R O Hynes	Cell	1992	1555235	No
82	6664	6664.0	0.0	0.0	COPPER ENZYMES IN ISOLATED CHLOROPLASTS. POLYPHENOLOXIDASE IN BETA VULGARIS.	D I Arnon	Plant Physiol	1949	16654194	Yes
83	6649	6649.0	370.67	370.7	Psychophysical bases of perceived exertion.	G A Borg	Med Sci Sports Exerc	1982	7154893	Yes
84	26566	6641.5	1175.72	293.9	A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.	M E Charlson, P Pompei, K L Ales, C R MacKenzie	J Chronic Dis	1987	3558716	Yes
85	6633	6633.0	196.55	196.6	Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.	M C Hochberg	Arthritis Rheum	1997	9324032	Yes
86	13222	6611.0	356.7	178.3	MrBayes 3: Bayesian phylogenetic inference under mixed models.	Fredrik Ronquist, John P Huelsenbeck	Bioinformatics	2003	12912839	Yes
87	13199	6599.5	299.75	149.9	Processing of X-ray diffraction data collected in oscillation mode.	Z Otwinowski, W Minor	Methods Enzymol	1997	27754618	Yes
88	6450	6450.0	210.89	210.9	AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.	R W Cox	Comput Biomed Res	1996	8812068	Yes
89	12888	6444.0	0.0	0.0	The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.	K Weber, M Osborn	J Biol Chem	1969	5806584	Yes
90	25609	6402.2	1185.75	296.4	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	PLoS Med	2009	19621072	No
91	12726	6363.0	376.64	188.3	Analyzing real-time PCR data by the comparative C(T) method.	Thomas D Schmittgen, Kenneth J Livak	Nat Protoc	2008	18546601	Yes
92	44347	6335.3	1274.31	182.0	Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.	S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman	Nucleic Acids Res	1997	9254694	No
93	6326	6326.0	201.33	201.3	Canonical dynamics: Equilibrium phase-space distributions.	Hoover	Phys Rev A Gen Phys	1985	9895674	Yes
94	18960	6320.0	777.68	259.2	NIH Image to ImageJ: 25 years of image analysis.	Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri	Nat Methods	2012	22930834	No
95	6318	6318.0	146.96	147.0	Chromatin modifications and their function.	Tony Kouzarides	Cell	2007	17320507	No
96	6315	6315.0	167.6	167.6	PAML 4: phylogenetic analysis by maximum likelihood.	Ziheng Yang	Mol Biol Evol	2007	17483113	Yes
97	25144	6286.0	946.14	236.5	Bias in meta-analysis detected by a simple, graphical test.	M Egger, G Davey Smith, M Schneider, C Minder	BMJ	1997	9310563	Yes
98	6245	6245.0	221.07	221.1	The blockade of immune checkpoints in cancer immunotherapy.	Drew M Pardoll	Nat Rev Cancer	2012	22437870	No
99	6244	6244.0	196.26	196.3	TreeView: an application to display phylogenetic trees on personal computers.	R D Page	Comput Appl Biosci	1996	8902363	Yes
100	12469	6234.5	291.38	145.7	Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana.	S J Clough, A F Bent	Plant J	1998	10069079	Yes
101	6205	6205.0	185.48	185.5	Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.	F Tajima	Genetics	1989	2513255	Yes
102	6173	6173.0	259.75	259.8	Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses.	Andreas Stang	Eur J Epidemiol	2010	20652370	Yes
103	6149	6149.0	246.01	246.0	Density-functional approximation for the correlation energy of the inhomogeneous electron gas.	Perdew	Phys Rev B Condens Matter	1986	9938299	Yes
104	6030	6030.0	168.41	168.4	Fast robust automated brain extraction.	Stephen M Smith	Hum Brain Mapp	2002	12391568	No
105	17523	5841.0	812.15	270.7	Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.	Michael I Love, Wolfgang Huber, Simon Anders	Genome Biol	2014	25516281	Yes
106	5839	5839.0	235.57	235.6	Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.	P S Thomas	Proc Natl Acad Sci U S A	1980	6159641	Yes
107	5812	5812.0	222.07	222.1	"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.	W N Burnette	Anal Biochem	1981	6266278	Yes
108	5790	5790.0	0.0	0.0	A simplification of the protein assay method of Lowry et al. which is more generally applicable.	G L Peterson	Anal Biochem	1977	603028	Yes
109	11327	5663.5	253.94	127.0	KEGG: kyoto encyclopedia of genes and genomes.	M Kanehisa, S Goto	Nucleic Acids Res	2000	10592173	Yes
110	5661	5661.0	167.32	167.3	Apoptosis: a review of programmed cell death.	Susan Elmore	Toxicol Pathol	2007	17562483	No
111	5636	5636.0	228.12	228.1	Ethical guidelines for investigations of experimental pain in conscious animals.	Manfred Zimmermann	Pain	1983	6877845	No
112	5629	5629.0	188.31	188.3	The VideoToolbox software for visual psychophysics: transforming numbers into movies.	D G Pelli	Spat Vis	1997	9176953	Yes
113	5589	5589.0	0.0	0.0	Solvent content of protein crystals.	B W Matthews	J Mol Biol	1968	5700707	Yes
114	5562	5562.0	329.92	329.9	Comparative fit indexes in structural models.	P M Bentler	Psychol Bull	1990	2320703	Yes
115	11082	5541.0	535.08	267.5	MAFFT multiple sequence alignment software version 7: improvements in performance and usability.	Kazutaka Katoh, Daron M Standley	Mol Biol Evol	2013	23329690	Yes
116	10843	5421.5	404.42	202.2	Sequencing end-labeled DNA with base-specific chemical cleavages.	A M Maxam, W Gilbert	Methods Enzymol	1980	6246368	Yes
117	5396	5396.0	116.97	117.0	Integrins: bidirectional, allosteric signaling machines.	Richard O Hynes	Cell	2002	12297042	No
118	16072	5357.3	814.23	271.4	Trimmomatic: a flexible trimmer for Illumina sequence data.	Anthony M Bolger, Marc Lohse, Bjoern Usadel	Bioinformatics	2014	24695404	Yes
119	5356	5356.0	0.0	0.0	A low-viscosity epoxy resin embedding medium for electron microscopy.	A R Spurr	J Ultrastruct Res	1969	4887011	Yes
120	5327	5327.0	0.0	0.0	Tumor angiogenesis: therapeutic implications.	J Folkman	N Engl J Med	1971	4938153	No
121	15977	5325.7	1358.1	452.7	MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.	Sudhir Kumar, Glen Stecher, Koichiro Tamura	Mol Biol Evol	2016	27004904	Yes
122	5266	5266.0	0.0	0.0	Evaluation of survival data and two new rank order statistics arising in its consideration.	N Mantel	Cancer Chemother Rep	1966	5910392	Yes
123	5249	5249.0	269.47	269.5	Investigation of the freely available easy-to-use software 'EZR' for medical statistics.	Y Kanda	Bone Marrow Transplant	2013	23208313	Yes
124	15720	5240.0	0.0	0.0	Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.	W T Friedewald, R I Levy, D S Fredrickson	Clin Chem	1972	4337382	Yes
125	5192	5192.0	196.74	196.7	The Clinical Dementia Rating (CDR): current version and scoring rules.	J C Morris	Neurology	1993	8232972	Yes
126	5174	5174.0	138.35	138.3	Inflammation, atherosclerosis, and coronary artery disease.	Göran K Hansson	N Engl J Med	2005	15843671	No
127	5168	5168.0	128.01	128.0	Inflammation in atherosclerosis.	Peter Libby	Nature	2002	12490960	No
128	5159	5159.0	201.47	201.5	The role of protein kinase C in cell surface signal transduction and tumour promotion.	Y Nishizuka	Nature	1984	6232463	No
129	15447	5149.0	566.11	188.7	A new generation of Ca2+ indicators with greatly improved fluorescence properties.	G Grynkiewicz, M Poenie, R Y Tsien	J Biol Chem	1985	3838314	Yes
130	5076	5076.0	152.21	152.2	Angiogenesis in cancer, vascular, rheumatoid and other disease.	J Folkman	Nat Med	1995	7584949	No
131	5076	5076.0	100.37	100.4	BLAT--the BLAST-like alignment tool.	W James Kent	Genome Res	2002	11932250	Yes
132	5037	5037.0	135.78	135.8	Biochemistry and molecular cell biology of diabetic complications.	M Brownlee	Nature	2001	11742414	Yes
133	5000	5000.0	119.32	119.3	p53, the cellular gatekeeper for growth and division.	A J Levine	Cell	1997	9039259	No
134	9995	4997.5	0.0	0.0	A rapid alkaline extraction procedure for screening recombinant plasmid DNA.	H C Birnboim, J Doly	Nucleic Acids Res	1979	388356	Yes
135	9968	4984.0	269.27	134.6	MRBAYES: Bayesian inference of phylogenetic trees.	J P Huelsenbeck, F Ronquist	Bioinformatics	2001	11524383	Yes
136	4983	4983.0	0.0	0.0	The assessment of anxiety states by rating.	M HAMILTON	Br J Med Psychol	1959	13638508	Yes
137	4968	4968.0	0.0	0.0	Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.	J R Vane	Nat New Biol	1971	5284360	Yes
138	4955	4955.0	133.01	133.0	Free radicals in the physiological control of cell function.	Wulf Dröge	Physiol Rev	2002	11773609	No
139	9848	4924.0	253.34	126.7	A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.	Stéphane Guindon, Olivier Gascuel	Syst Biol	2003	14530136	Yes
140	4917	4917.0	0.0	0.0	Development of a rating scale for primary depressive illness.	M Hamilton	Br J Soc Clin Psychol	1967	6080235	Yes
141	9697	4848.5	0.0	0.0	Intraclass correlations: uses in assessing rater reliability.	P E Shrout, J L Fleiss	Psychol Bull	1979	18839484	No
142	9688	4844.0	0.0	0.0	Continuous cultures of fused cells secreting antibody of predefined specificity.	G Köhler, C Milstein	Nature	1975	1172191	Yes
143	14513	4837.7	530.01	176.7	Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.	Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien	Ann Surg	2004	15273542	Yes
144	9664	4832.0	236.7	118.3	Dendritic cells and the control of immunity.	J Banchereau, R M Steinman	Nature	1998	9521319	No
145	9659	4829.5	233.91	117.0	One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.	K A Datsenko, B L Wanner	Proc Natl Acad Sci U S A	2000	10829079	Yes
146	9650	4825.0	414.88	207.4	The meaning and use of the area under a receiver operating characteristic (ROC) curve.	J A Hanley, B J McNeil	Radiology	1982	7063747	Yes
147	9648	4824.0	0.0	0.0	Prediction of creatinine clearance from serum creatinine.	D W Cockcroft, M H Gault	Nephron	1976	1244564	Yes
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